valproic acid has been researched along with Chromosomal Instability in 2 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chromosomal Instability: An increased tendency to acquire CHROMOSOME ABERRATIONS when various processes involved in chromosome replication, repair, or segregation are dysfunctional.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To determine the role of gene overexpression on chromosome instability (CIN), we performed genome-wide screens in the budding yeast for yeast genes that cause CIN when overexpressed, a phenotype we refer to as dosage CIN (dCIN), and identified 245 dCIN genes." | 1.43 | Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer. ( Andrews, B; Ang, JS; Boerkoel, CF; Duffy, S; Fam, HK; Hieter, P; Kim, JH; Larionov, V; Shah, SP; Singh, T; Styles, EB; Wang, YK, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Duffy, S | 1 |
| Fam, HK | 1 |
| Wang, YK | 1 |
| Styles, EB | 1 |
| Kim, JH | 1 |
| Ang, JS | 1 |
| Singh, T | 1 |
| Larionov, V | 1 |
| Shah, SP | 1 |
| Andrews, B | 1 |
| Boerkoel, CF | 1 |
| Hieter, P | 1 |
| Robert, T | 1 |
| Vanoli, F | 1 |
| Chiolo, I | 1 |
| Shubassi, G | 1 |
| Bernstein, KA | 1 |
| Rothstein, R | 1 |
| Botrugno, OA | 1 |
| Parazzoli, D | 1 |
| Oldani, A | 1 |
| Minucci, S | 1 |
| Foiani, M | 1 |
2 other studies available for valproic acid and Chromosomal Instability
| Article | Year |
|---|---|
Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer.
Topics: Cell Line, Tumor; Chromosomal Instability; Gene Expression Regulation, Neoplastic; Histone Deacetyla | 2016 |
HDACs link the DNA damage response, processing of double-strand breaks and autophagy.
Topics: Acetylation; Aminopeptidases; Autophagy; Autophagy-Related Protein 8 Family; Autophagy-Related Prote | 2011 |