valproic acid has been researched along with Choriocarcinoma in 5 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Choriocarcinoma: A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid is an anticonvulsant widely used for the treatment of epilepsy." | 5.31 | Uptake mechanism of valproic acid in human placental choriocarcinoma cell line (BeWo). ( Matsuo, H; Nakano, H; Ohtani, H; Sawada, Y; Takanaga, H; Tsukimori, K; Ushigome, F, 2001) |
| "Valproic acid is an anticonvulsant widely used for the treatment of epilepsy." | 1.31 | Uptake mechanism of valproic acid in human placental choriocarcinoma cell line (BeWo). ( Matsuo, H; Nakano, H; Ohtani, H; Sawada, Y; Takanaga, H; Tsukimori, K; Ushigome, F, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kurosawa, Y | 1 |
| Furugen, A | 1 |
| Nishimura, A | 1 |
| Narumi, K | 1 |
| Kobayashi, M | 1 |
| Iseki, K | 1 |
| Van Twisk, D | 1 |
| Murphy, SP | 1 |
| Thakar, J | 1 |
| Kwiecińska, P | 1 |
| Wiśniewska, J | 1 |
| Gregoraszczuk, EŁ | 1 |
| Utoguchi, N | 1 |
| Audus, KL | 1 |
| Ushigome, F | 1 |
| Takanaga, H | 1 |
| Matsuo, H | 1 |
| Tsukimori, K | 1 |
| Nakano, H | 1 |
| Ohtani, H | 1 |
| Sawada, Y | 1 |
5 other studies available for valproic acid and Choriocarcinoma
| Article | Year |
|---|---|
Evaluation of the effects of antiepileptic drugs on folic acid uptake by human placental choriocarcinoma cells.
Topics: Adult; Anticonvulsants; Cell Line, Tumor; Cell Survival; Choriocarcinoma; Female; Folate Receptor 1; | 2018 |
Optimized logic rules reveal interferon-γ-induced modes regulated by histone deacetylases and protein tyrosine phosphatases.
Topics: Animals; Cell Line, Tumor; Choriocarcinoma; Computer Simulation; Epigenetic Repression; Female; Gene | 2017 |
Effects of valproic acid (VPA) and levetiracetam (LEV) on proliferation, apoptosis and hormone secretion of the human choriocarcinoma BeWo cell line.
Topics: Anticonvulsants; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Proliferation; Choriocarcinoma; Chorio | 2011 |
Carrier-mediated transport of valproic acid in BeWo cells, a human trophoblast cell line.
Topics: Anticonvulsants; Biological Transport; Carboxylic Acids; Choriocarcinoma; Female; Humans; Hydrogen-I | 2000 |
Uptake mechanism of valproic acid in human placental choriocarcinoma cell line (BeWo).
Topics: 3-O-Methylglucose; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Alanine; Anticonvulsants; Biolo | 2001 |