Page last updated: 2024-10-26

valproic acid and Chorea

valproic acid has been researched along with Chorea in 45 studies

Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.

Chorea: Involuntary, forcible, rapid, jerky movements that may be subtle or become confluent, markedly altering normal patterns of movement. Hypotonia and pendular reflexes are often associated. Conditions which feature recurrent or persistent episodes of chorea as a primary manifestation of disease are referred to as CHOREATIC DISORDERS. Chorea is also a frequent manifestation of BASAL GANGLIA DISEASES.

Research Excerpts

ExcerptRelevanceReference
"To evaluate and compare the efficacies of sodium valproate and carbamazepine in the treatment of the choreiform movements in Sydenham's chorea."9.10Sydenham's chorea: clinical findings and comparison of the efficacies of sodium valproate and carbamazepine regimens. ( Arslanoglu, S; Genel, F; Saylan, B; Uran, N, 2002)
"To study the effect of levetiracetam in treating Sydenham chorea."7.96Efficacy of levetiracetam in the treatment of Sydenham chorea. ( Direk, M; Epcacan, S; Epcacan, Z; Okuyaz, C; Yildirim, DD, 2020)
"In order to compare and contrast the efficacy of haloperidol, carbamazepine, and valproic acid in the treatment of Sydenham's chorea a prospective study including 18 cases of this disorder was undertaken."7.71Comparison of the efficacy of carbamazepine, haloperidol and valproic acid in the treatment of children with Sydenham's chorea: clinical follow-up of 18 patients. ( Cardozo, J; Molina, O; Montiel, C; Mora, E; Peña, J, 2002)
"To evaluate and compare the efficacies of sodium valproate and carbamazepine in the treatment of the choreiform movements in Sydenham's chorea."5.10Sydenham's chorea: clinical findings and comparison of the efficacies of sodium valproate and carbamazepine regimens. ( Arslanoglu, S; Genel, F; Saylan, B; Uran, N, 2002)
"To study the effect of levetiracetam in treating Sydenham chorea."3.96Efficacy of levetiracetam in the treatment of Sydenham chorea. ( Direk, M; Epcacan, S; Epcacan, Z; Okuyaz, C; Yildirim, DD, 2020)
"In order to compare and contrast the efficacy of haloperidol, carbamazepine, and valproic acid in the treatment of Sydenham's chorea a prospective study including 18 cases of this disorder was undertaken."3.71Comparison of the efficacy of carbamazepine, haloperidol and valproic acid in the treatment of children with Sydenham's chorea: clinical follow-up of 18 patients. ( Cardozo, J; Molina, O; Montiel, C; Mora, E; Peña, J, 2002)
"Three patients who developed chorea during long-term treatment with valproic acid."3.69Choreiform movements associated with the use of valproate. ( Asconapé, JJ; Lancman, ME; Penry, JK, 1994)
"A diagnosis of Sydenham's chorea in a patient with acute chorea involves an application of the Jones criteria and the exclusion of other causes of chorea."2.46Sydenham's chorea: a practical overview of the current literature. ( Oosterveer, DM; Overweg-Plandsoen, WC; Roos, RA, 2010)
"Sydenham's chorea is a symptom of rheumatic fever and results from an autoimmune attack on the CNS."2.39Neuropsychiatric aspects of Sydenham's chorea: a comprehensive review. ( Moore, DP, 1996)
"The treatment of Sydenham's chorea was based on neuroleptics."1.46[Exceptionally good response to sodium valproate in patients with recurrent Sydenham's chorea]. ( Belahsen, MF; Bouchal, S; Ouali, O, 2017)
"This case reminds us that Sydenham's chorea can result in major functional impairment."1.43Successful treatment of Sydenham's chorea with intravenous immunoglobulin. ( Boersma, NA; Heidema, J; Kuijpers, T; Schippers, H, 2016)
"Chorea is a rare and dose dependent side effect of valproate."1.37Acute chorea caused by valproate in an elderly. ( Cras, P; Helsen, G; van de Velde, K, 2011)
"Rheumatic fever is common in India and the incidence has not shown the declining trends seen in the developed countries."1.35Youngest patient with Sydenham's chorea: a case report. ( Premkumar, S; Ramanan, PV; Ramnath, B, 2009)
"An important subset of children with nonketotic hyperglycinemia are atypical variants who present in a heterogeneous manner."1.33Valproate-induced chorea and encephalopathy in atypical nonketotic hyperglycinemia. ( Morrison, PF; Sankar, R; Shields, WD, 2006)
"Valproic acid and pimozide were then successively prescribed because of the chorea."1.32[A child with peculiar movements: Sydenham chorea]. ( Koehler, PJ; Munts, AG; Wennekes, MJ, 2003)
"Nine patients presented with Sydenham's chorea as one of the major criteria (one or more attacks) were evaluated their clinical characteristics and treatment."1.32Sydenham's chorea-clinical characteristics of nine patients. ( Davutoglu, V; Dinckal, H; Kilinc, M; Sezen, Y; Soydinc, S, 2004)
"In our study, we report a patient having head trauma history with partial and secondary generalized seizures taking 1500 mg/day valproate."1.31Reversible valproate-induced choreiform movements. ( Bingol, CA; Guleryuz, M; Gunal, DI, 2002)
"Haloperidol was the most prescribed medication (15 patients - 75 %)."1.31Management of rheumatic chorea: an observational study. ( Araujo, AP; Maia Filho, HS; Padua, PA, 2002)
"We treated 15 children with Sydenham's chorea with sodium valproate at a dose of 15 to 20 mg/kg/d."1.28Effectiveness of sodium valproate in the treatment of Sydenham's chorea. ( al-Saleh, Q; Daoud, AS; Shakir, R; Zaki, M, 1990)
"Treatment with carbamazepine or phenytoin was effective, but haloperidol increased the severity of the choreoathetoid attacks."1.27Therapeutic aspects of kinesiogenic paroxysmal choreoathetosis and familial paroxysmal choreoathetosis of the Mount and Reback type. ( Monninger, P; Przuntek, H, 1983)

Research

Studies (45)

TimeframeStudies, this research(%)All Research%
pre-199015 (33.33)18.7374
1990's10 (22.22)18.2507
2000's11 (24.44)29.6817
2010's7 (15.56)24.3611
2020's2 (4.44)2.80

Authors

AuthorsStudies
Tariq, S1
Niaz, F1
Waseem, S1
Shaikh, TG1
Ahmed, SH1
Irfan, M1
Nashwan, AJ1
Ullah, I1
Direk, M1
Epcacan, S1
Epcacan, Z1
Yildirim, DD1
Okuyaz, C1
Bouchal, S1
Ouali, O1
Belahsen, MF1
Boersma, NA1
Schippers, H1
Kuijpers, T1
Heidema, J1
Ramanan, PV1
Premkumar, S1
Ramnath, B1
Sabui, TK1
Pant, P1
Beato, R1
Maia, DP2
Teixeira, AL2
Cardoso, F2
Srinivasan, S1
Lok, AW1
Oosterveer, DM1
Overweg-Plandsoen, WC1
Roos, RA1
van de Velde, K1
Cras, P1
Helsen, G1
Peña, J1
Mora, E1
Cardozo, J1
Molina, O1
Montiel, C1
Mukhin, KIu1
Maksimova, EV1
Glukhova, LIu1
Petrukhin, AS2
Petrukhin, AA1
Mironov, MB1
Gaman, OV1
Munts, AG1
Wennekes, MJ1
Koehler, PJ1
Davutoglu, V1
Kilinc, M1
Dinckal, H1
Soydinc, S1
Sezen, Y1
Robinson, D1
Smith, M1
Reddy, R1
Morrison, PF1
Sankar, R1
Shields, WD1
Kummer, A1
Przuntek, H1
Monninger, P1
Puca, FM1
Genco, S1
Minervini, MG1
Specchio, LM1
Napoletano, V1
Brancasi, B1
Reggio, F1
Sandyk, R1
Chandra, V1
Spunt, AL1
Rusinowitz, MS1
Dhanaraj, M3
Srinivas, K3
Panneer, A1
Suber, DA1
Riley, TL1
Lenton, RJ1
Copti, M1
Smith, RG1
McLachlan, RS1
Lancman, ME1
Asconapé, JJ1
Penry, JK1
Song, CH1
Oftadeh, LC1
Oh, C1
Louie, J1
Yu, KT1
Moore, DP1
Ronchezel, MV1
Hilario, MO1
Forleo, LH1
Len, CA1
Terreri, MT1
Vilanova, LC1
Sole, D1
Genel, F1
Arslanoglu, S1
Uran, N1
Saylan, B1
Gunal, DI1
Guleryuz, M1
Bingol, CA1
Araujo, AP1
Padua, PA1
Maia Filho, HS1
Godwin-Austen, RB1
Kulkarni, ML2
Cornelio-Nieto, JO1
Lastra-Escudero, LG1
Ramírez-Aguilera, MJ1
Rodríguez-Ruiz, FJ1
Valdéz-Pérez, G1
Hoffman, AS1
Feinberg, TE1
Daoud, AS1
Zaki, M1
Shakir, R1
al-Saleh, Q1
Sethi, KD1
Patel, BP1
Giroud, M1
Dumas, R1
Steinberg, A1
Reifen, RM1
Leifer, M1
Appleton, RE1
Jan, JE1
Hernández, MA1
Valencia, ME1
Castillo, R1
Anciones, B1
Radhakrishnan, AR1
Sayeed, ZA1

Reviews

3 reviews available for valproic acid and Chorea

ArticleYear
Managing and treating Sydenham chorea: A systematic review.
    Brain and behavior, 2023, Volume: 13, Issue:6

    Topics: Anticonvulsants; Chorea; Dopamine Antagonists; Female; Haloperidol; Humans; Male; Valproic Acid

2023
Sydenham's chorea: a practical overview of the current literature.
    Pediatric neurology, 2010, Volume: 43, Issue:1

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Chorea; Humans; Valproic Acid

2010
Neuropsychiatric aspects of Sydenham's chorea: a comprehensive review.
    The Journal of clinical psychiatry, 1996, Volume: 57, Issue:9

    Topics: Adult; Autoimmune Diseases; Chorea; Comorbidity; Haloperidol; Humans; Mental Disorders; Obsessive-Co

1996

Trials

1 trial available for valproic acid and Chorea

ArticleYear
Sydenham's chorea: clinical findings and comparison of the efficacies of sodium valproate and carbamazepine regimens.
    Brain & development, 2002, Volume: 24, Issue:2

    Topics: Adolescent; Carbamazepine; Child; Cholinergic Agents; Chorea; Drug Administration Schedule; Female;

2002

Other Studies

41 other studies available for valproic acid and Chorea

ArticleYear
Efficacy of levetiracetam in the treatment of Sydenham chorea.
    Pediatrics international : official journal of the Japan Pediatric Society, 2020, Volume: 62, Issue:11

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Chorea; Female; Haloperidol; Humans; Levetiraceta

2020
[Exceptionally good response to sodium valproate in patients with recurrent Sydenham's chorea].
    The Pan African medical journal, 2017, Volume: 27

    Topics: Adolescent; Anticonvulsants; Chorea; Female; Follow-Up Studies; Haloperidol; Humans; Recurrence; Rhe

2017
Successful treatment of Sydenham's chorea with intravenous immunoglobulin.
    BMJ case reports, 2016, Feb-01, Volume: 2016

    Topics: Anti-Bacterial Agents; Child; Chorea; Disease Progression; Female; Haloperidol; Humans; Immunoglobul

2016
Youngest patient with Sydenham's chorea: a case report.
    Journal of the Indian Medical Association, 2009, Volume: 107, Issue:4

    Topics: Anti-Bacterial Agents; Antimanic Agents; Child, Preschool; Chorea; Drug Therapy, Combination; Echoca

2009
Sodium valproate in the treatment of Sydenham's chorea.
    Indian journal of pediatrics, 2010, Volume: 77, Issue:6

    Topics: Anticonvulsants; Child; Chorea; Female; Humans; Prospective Studies; Treatment Outcome; Valproic Aci

2010
Executive functioning in adult patients with Sydenham's chorea.
    Movement disorders : official journal of the Movement Disorder Society, 2010, May-15, Volume: 25, Issue:7

    Topics: Adolescent; Adult; Age of Onset; Anti-Bacterial Agents; Anti-Dyskinesia Agents; Anticonvulsants; Cho

2010
Valproate-induced reversible hemichorea.
    Movement disorders : official journal of the Movement Disorder Society, 2010, Jul-30, Volume: 25, Issue:10

    Topics: Anticonvulsants; Brain; Chorea; Epilepsy; Functional Laterality; Humans; Magnetic Resonance Imaging;

2010
Acute chorea caused by valproate in an elderly.
    Acta neurologica Belgica, 2011, Volume: 111, Issue:3

    Topics: Acute Disease; Aged, 80 and over; Anticonvulsants; Chorea; Dose-Response Relationship, Drug; Female;

2011
Comparison of the efficacy of carbamazepine, haloperidol and valproic acid in the treatment of children with Sydenham's chorea: clinical follow-up of 18 patients.
    Arquivos de neuro-psiquiatria, 2002, Volume: 60, Issue:2-B

    Topics: Adolescent; Anti-Dyskinesia Agents; Antimanic Agents; Carbamazepine; Child; Chorea; Female; Follow-U

2002
[A case of familial paroxysmal kinesic choreoathetosis].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2002, Volume: 102, Issue:8

    Topics: Anticonvulsants; Athetosis; Carbamazepine; Child; Chorea; Diazepam; Drug Therapy, Combination; Human

2002
[A child with peculiar movements: Sydenham chorea].
    Nederlands tijdschrift voor geneeskunde, 2003, Feb-08, Volume: 147, Issue:6

    Topics: Anti-Dyskinesia Agents; Child; Chorea; Female; Humans; Pimozide; Rheumatic Fever; Treatment Outcome;

2003
Sydenham's chorea-clinical characteristics of nine patients.
    International journal of cardiology, 2004, Volume: 96, Issue:3

    Topics: Anticonvulsants; Child; Chorea; Female; Humans; Male; Retrospective Studies; Turkey; Valproic Acid

2004
Neuroacanthocytosis.
    The American journal of psychiatry, 2004, Volume: 161, Issue:9

    Topics: Adult; Anticonvulsants; Antipsychotic Agents; Chorea; Female; Humans; Molindone; Treatment Outcome;

2004
Valproate-induced chorea and encephalopathy in atypical nonketotic hyperglycinemia.
    Pediatric neurology, 2006, Volume: 35, Issue:5

    Topics: Anticonvulsants; Brain Diseases; Child; Chorea; Female; Humans; Hyperglycinemia, Nonketotic; Valproi

2006
Trichotillomania in acute Sydenham's chorea.
    The Australian and New Zealand journal of psychiatry, 2007, Volume: 41, Issue:12

    Topics: Acute Disease; Adolescent; Anticonvulsants; Chorea; Comorbidity; Female; Humans; Penicillin G Benzat

2007
Therapeutic aspects of kinesiogenic paroxysmal choreoathetosis and familial paroxysmal choreoathetosis of the Mount and Reback type.
    Journal of neurology, 1983, Volume: 230, Issue:3

    Topics: Adolescent; Adult; Aged; Alcohol Drinking; Athetosis; Carbamazepine; Child; Chorea; Female; Haloperi

1983
[Sleep in chronic chorea patients after therapy with sodium valproate].
    Bollettino della Societa italiana di biologia sperimentale, 1984, May-30, Volume: 60, Issue:5

    Topics: Adult; Chorea; Chronic Disease; Female; gamma-Aminobutyric Acid; Humans; Huntington Disease; Male; M

1984
Sodium valproate and baclofen for Sydenham's chorea.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1983, Jul-02, Volume: 64, Issue:1

    Topics: Adolescent; Baclofen; Chorea; Drug Therapy, Combination; Female; Humans; Valproic Acid

1983
Treatment of post-traumatic choreo-athetosis with sodium valproate.
    Journal of neurology, neurosurgery, and psychiatry, 1983, Volume: 46, Issue:10

    Topics: Adult; Athetosis; Brain Injuries; Chorea; Humans; Male; Valproic Acid

1983
Sydenham's chorea.
    Indian pediatrics, 1984, Volume: 21, Issue:1

    Topics: Adolescent; Chorea; Humans; Male; Valproic Acid

1984
Sydenham's chorea treated with sodium valproate.
    The Journal of the Association of Physicians of India, 1984, Volume: 32, Issue:11

    Topics: Adolescent; Brain Chemistry; Chorea; gamma-Aminobutyric Acid; Humans; Male; Valproic Acid

1984
Valproic acid and normal computerized tomographic scan in kinesiogenic familial paroxysmal choreoathetosis.
    Archives of neurology, 1980, Volume: 37, Issue:5

    Topics: Adolescent; Athetosis; Chorea; Female; Humans; Tomography, X-Ray Computed; Valproic Acid

1980
Hemiballismus treated with sodium valproate.
    British medical journal (Clinical research ed.), 1981, Jul-04, Volume: 283, Issue:6283

    Topics: Aged; Chorea; Humans; Male; Valproic Acid

1981
Valproic acid in Sydenham's chorea.
    British medical journal (Clinical research ed.), 1981, Jul-25, Volume: 283, Issue:6286

    Topics: Adult; Anticonvulsants; Chorea; Female; Humans; Valproic Acid

1981
Choreiform movements associated with the use of valproate.
    Archives of neurology, 1994, Volume: 51, Issue:7

    Topics: Adolescent; Adult; Brain Injuries; Child; Chorea; Epilepsy; Female; Humans; Male; Valproic Acid

1994
Successful treatment of steroid-resistant chorea associated with lupus by use of valproic acid and clonidine-HCL patch.
    Clinical pediatrics, 1997, Volume: 36, Issue:11

    Topics: Administration, Oral; Adolescent; Chorea; Clonidine; Female; Humans; Injections, Intravenous; Lupus

1997
The use of haloperidol and valproate in children with Sydenham chorea.
    Indian pediatrics, 1998, Volume: 35, Issue:12

    Topics: Adolescent; Alanine Transaminase; Anti-Dyskinesia Agents; Anticonvulsants; Aspartate Aminotransferas

1998
Reversible valproate-induced choreiform movements.
    Seizure, 2002, Volume: 11, Issue:3

    Topics: Adult; Anticonvulsants; Chorea; Craniocerebral Trauma; Epilepsy; Humans; Male; Time Factors; Valproi

2002
Management of rheumatic chorea: an observational study.
    Arquivos de neuro-psiquiatria, 2002, Volume: 60, Issue:2-A

    Topics: Anti-Dyskinesia Agents; Child; Chorea; Cross-Sectional Studies; Diazepam; Female; Haloperidol; Human

2002
The treatment of the choreas and athetotic dystonias.
    Journal of the Royal College of Physicians of London, 1979, Volume: 13, Issue:1

    Topics: Adult; Athetosis; Benzodiazepines; Child; Chorea; Dystonia; Haloperidol; Humans; Levodopa; Movement

1979
Sodium valproate controls choreoathetoid movements of kernicterus.
    Indian pediatrics, 1992, Volume: 29, Issue:8

    Topics: Blood Transfusion; Child, Preschool; Chorea; Developmental Disabilities; Female; Humans; Kernicterus

1992
Sodium valproate in Sydenham's chorea.
    Indian pediatrics, 1992, Volume: 29, Issue:3

    Topics: Adolescent; Adult; Child; Child, Preschool; Chorea; Humans; Valproic Acid

1992
[Valproic acid in the management of Sydenham's chorea].
    Boletin medico del Hospital Infantil de Mexico, 1991, Volume: 48, Issue:4

    Topics: Child; Chorea; Female; Humans; Syndrome; Valproic Acid

1991
Successful treatment of age-related chorea with sodium valproate.
    Journal of the American Geriatrics Society, 1990, Volume: 38, Issue:1

    Topics: Aged; Aged, 80 and over; Chorea; Female; Follow-Up Studies; Humans; Valproic Acid

1990
Effectiveness of sodium valproate in the treatment of Sydenham's chorea.
    Neurology, 1990, Volume: 40, Issue:7

    Topics: Acute Disease; Adolescent; Child; Child, Preschool; Chorea; Female; Humans; Male; Recurrence; Rheuma

1990
Inconsistent response to divalproex sodium in hemichorea/hemiballism.
    Neurology, 1990, Volume: 40, Issue:10

    Topics: Aged; Chorea; Dose-Response Relationship, Drug; Humans; Male; Movement Disorders; Thalamus; Valproic

1990
Valproate sodium in postanoxic choreoathetosis.
    Journal of child neurology, 1986, Volume: 1, Issue:1

    Topics: Adolescent; Athetosis; Child; Chorea; Humans; Valproic Acid

1986
Efficacy of valproic acid in the treatment of Sydenham's chorea.
    Journal of child neurology, 1987, Volume: 2, Issue:3

    Topics: Child; Chorea; Female; Follow-Up Studies; Humans; Valproic Acid

1987
Efficacy of valproic acid in the treatment of Sydenham's chorea.
    Journal of child neurology, 1988, Volume: 3, Issue:2

    Topics: Adolescent; Chorea; Haloperidol; Humans; Male; Valproic Acid

1988
[Sodium valproate in the treatment of choreoathetosis].
    Medicina clinica, 1988, Mar-26, Volume: 90, Issue:12

    Topics: Adult; Athetosis; Chorea; Humans; Male; Toxoplasmosis; Valproic Acid

1988
Sodium valproate in Sydenham's chorea.
    Neurology, 1985, Volume: 35, Issue:1

    Topics: Adolescent; Chorea; Humans; Male; Movement; Valproic Acid

1985