valproic acid has been researched along with Cholestasis in 9 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Cholestasis: Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Glioblastoma patients undergoing treatment with surgery followed by radiation and temozolomide chemotherapy often develop a state of immunosuppression and are at risk for opportunistic infections and reactivation of hepatitis and herpes viruses." | 7.74 | Valproic acid related idiosyncratic drug induced hepatotoxicity in a glioblastoma patient treated with temozolomide. ( Hoorens, A; Neyns, B; Stupp, R, 2008) |
| "Glioblastoma patients undergoing treatment with surgery followed by radiation and temozolomide chemotherapy often develop a state of immunosuppression and are at risk for opportunistic infections and reactivation of hepatitis and herpes viruses." | 3.74 | Valproic acid related idiosyncratic drug induced hepatotoxicity in a glioblastoma patient treated with temozolomide. ( Hoorens, A; Neyns, B; Stupp, R, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (33.33) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dawson, S | 1 |
| Stahl, S | 1 |
| Paul, N | 1 |
| Barber, J | 1 |
| Kenna, JG | 1 |
| Amathieu, R | 1 |
| Levesque, E | 1 |
| Merle, JC | 1 |
| Chemit, M | 1 |
| Costentin, C | 1 |
| Compagnon, P | 1 |
| Dhonneur, G | 1 |
| Vinken, M | 1 |
| Neyns, B | 1 |
| Hoorens, A | 1 |
| Stupp, R | 1 |
| Kolts, BE | 1 |
| Langfitt, M | 1 |
| Le Bihan, G | 1 |
| Bourreille, J | 1 |
| Sampson, M | 1 |
| Leroy, J | 1 |
| Szekely, AM | 1 |
| Coquerel, A | 1 |
| Froomes, PR | 1 |
| Stewart, MR | 1 |
| Védrine, L | 1 |
| Biance, N | 1 |
| Souleau, B | 1 |
| Nedellec, G | 1 |
| de Revel, T | 1 |
| Bach, N | 1 |
| Thung, SN | 1 |
| Schaffner, F | 1 |
| Tobias, H | 1 |
2 reviews available for valproic acid and Cholestasis
| Article | Year |
|---|---|
[Severe toxic acute liver failure: etiology and treatment].
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Anti-Infective Agents; Blood Coagulation Disorde | 2013 |
Adverse Outcome Pathways and Drug-Induced Liver Injury Testing.
Topics: Bosentan; Chemical and Drug Induced Liver Injury; Cholestasis; Fatty Liver; Humans; Liver Cirrhosis; | 2015 |
7 other studies available for valproic acid and Cholestasis
| Article | Year |
|---|---|
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Valproic acid related idiosyncratic drug induced hepatotoxicity in a glioblastoma patient treated with temozolomide.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemical and Drug Induced Liver Injury; Chemothe | 2008 |
Drugs and the liver.
Topics: Acetaminophen; Adult; Aspirin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liv | 1984 |
Fatal hepatic failure and sodium valproate.
Topics: Adolescent; Cholestasis; Epilepsy, Absence; Female; Hepatic Encephalopathy; Humans; Valproic Acid | 1980 |
A reversible parkinsonian syndrome and hepatotoxcity following addition of carbamazepine to sodium valproate.
Topics: Aged; Carbamazepine; Chemical and Drug Induced Liver Injury; Cholestasis; Drug Interactions; Drug Th | 1994 |
[Agranulocytosis and simultaneous cholestatic jaundice induced by sodium valproate in an elderly woman].
Topics: Age Factors; Aged; Agranulocytosis; Anticonvulsants; Cholestasis; Female; Humans; Valproic Acid | 2001 |
Exaggerated cholestasis and hepatic fibrosis following simultaneous administration of chlorpromazine and sodium valproate.
Topics: Chlorpromazine; Cholestasis; Drug Interactions; Hiccup; Humans; Liver Cirrhosis; Male; Middle Aged; | 1989 |