valproic acid has been researched along with Cholera Infantum in 23 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To correlate lamotrigine (LTG) serum concentrations (levels) with tolerability in patients with epilepsy." | 8.82 | Correlating lamotrigine serum concentrations with tolerability in patients with epilepsy. ( Adams, DJ; Bazil, CW; Buchsbaum, R; Du, Y; Hager, M; Hirsch, LJ; Morrell, MJ; Resor, SR; Spencer, HT; Straka, T; Weintraub, D, 2004) |
| "Side effects of carbamazepine (CBZ), valproate (VPA) and clonazepam (CZP) are rare during long-term use but rather common and usually transient during the early phases of treatment." | 5.27 | Side effects of carbamazepine, valproate and clonazepam during long-term treatment of epilepsy. ( Keränen, T; Sivenius, J, 1983) |
| "To correlate lamotrigine (LTG) serum concentrations (levels) with tolerability in patients with epilepsy." | 4.82 | Correlating lamotrigine serum concentrations with tolerability in patients with epilepsy. ( Adams, DJ; Bazil, CW; Buchsbaum, R; Du, Y; Hager, M; Hirsch, LJ; Morrell, MJ; Resor, SR; Spencer, HT; Straka, T; Weintraub, D, 2004) |
| "The side effects and possible side effects of the therapy with valproic acid were documented in 66 outpatients with epilepsy over a period of one year." | 3.66 | [Antiepileptic therapy with valproinic acid. Correlations of side effects and serum levels of valproinic acid]. ( Fröscher, W; Gugler, R; Schulz, HU, 1979) |
| " The adverse effect (AE) profile of this combination needs clarification." | 2.69 | Adding lamotrigine to valproate: incidence of rash and other adverse effects. Postmarketing Antiepileptic Drug Survey (PADS) Group. ( Faught, E; French, J; Harden, C; Jacobson, M; Montouris, G; Morris, G; Rosenfeld, W, 1999) |
| "Although survival rates for acute lymphocytic leukemia (ALL), especially in children, have shown dramatic improvement over time, poor outcomes are still observed in patients who have refractory or relapsed disease after conventional chemotherapy." | 2.49 | Recent advancements of bortezomib in acute lymphocytic leukemia treatment. ( Chen, Q; Du, XL, 2013) |
| "However, the development of the autism-related gut microbiota and its relationship with intestinal dysfunction in ASD remain unclear." | 1.72 | Congenitally underdeveloped intestine drives autism-related gut microbiota and behavior. ( Chen, M; Cheng, M; Gao, X; He, Y; Li, H; Li, J; Li, Z; Liu, F; Meng, F; Qing, W; Shen, W; Shi, Y; Wang, H; Wang, Q; Wu, F; Zeng, N; Zhou, H, 2022) |
| " In the early phase of treatment, the main adverse effects included drowsiness, dizziness, and anorexia." | 1.37 | A 6-month prospective study on efficacy safety and QOL profiles of extended-release formulation of valproate in patients with epilepsy. ( Hong, Z; Li, T; Wang, B; Wu, XY; Xu, L; Yu, PM; Yue, L; Zhu, GX, 2011) |
| " Adverse events and reasons for terminating the diet were tabulated." | 1.33 | Safety and tolerability of the ketogenic diet in pediatric epilepsy: effects of valproate combination therapy. ( Ghosh, S; Lyczkowski, DA; Pfeifer, HH; Thiele, EA, 2005) |
| " Patients treated with divalproex sodium compared with patients treated with valproic acid were less likely to experience gastrointestinal side effects and to have discontinued their medication because of an adverse event." | 1.30 | The adverse effect profile and efficacy of divalproex sodium compared with valproic acid: a pharmacoepidemiology study. ( Madrid, AR; McDonald, J; Narendran, R; Sederer, M; Tohen, M; Tomassini, EC; Zarate, CA, 1999) |
| " Although the absorption of DS was delayed, the bioavailability of VA capsules and DS tablets was equivalent." | 1.27 | Gastrointestinal tolerance of divalproex sodium. ( Asconape, J; Karas, BJ; Penry, JK; Wilder, BJ, 1983) |
| "Side effects of carbamazepine (CBZ), valproate (VPA) and clonazepam (CZP) are rare during long-term use but rather common and usually transient during the early phases of treatment." | 1.27 | Side effects of carbamazepine, valproate and clonazepam during long-term treatment of epilepsy. ( Keränen, T; Sivenius, J, 1983) |
| " Twenty-three patients complained of various long-term adverse effects, while the other 17 remained symptom-free." | 1.27 | Long-term treatment with sodium valproate: monitoring of venous ammonia concentrations and adverse effects. ( Arnetoli, G; Campostrini, R; Messori, A; Paganini, M; Valenza, T; Zaccara, G; Zappoli, R, 1987) |
| "Thirty children with simple febrile convulsions were treated with sodium valproate following their second convulsion." | 1.26 | Sodium valproate in the prophylaxis of simple febrile convulsions. ( Evans-Jones, LG; Groom, PJ; Kindley, AD; Williams, AJ, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (34.78) | 18.7374 |
| 1990's | 3 (13.04) | 18.2507 |
| 2000's | 8 (34.78) | 29.6817 |
| 2010's | 3 (13.04) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Li, J | 1 |
| Wang, H | 1 |
| Qing, W | 1 |
| Liu, F | 1 |
| Zeng, N | 1 |
| Wu, F | 1 |
| Shi, Y | 1 |
| Gao, X | 1 |
| Cheng, M | 1 |
| Li, H | 1 |
| Shen, W | 1 |
| Meng, F | 1 |
| He, Y | 1 |
| Chen, M | 1 |
| Li, Z | 1 |
| Zhou, H | 1 |
| Wang, Q | 1 |
| Novick, D | 1 |
| Gonzalez-Pinto, A | 1 |
| Haro, JM | 1 |
| Bertsch, J | 1 |
| Reed, C | 1 |
| Perrin, E | 1 |
| Tohen, M | 2 |
| Yu, PM | 1 |
| Zhu, GX | 1 |
| Wu, XY | 1 |
| Li, T | 1 |
| Xu, L | 1 |
| Yue, L | 1 |
| Wang, B | 1 |
| Hong, Z | 1 |
| Gekht, AB | 1 |
| Du, XL | 1 |
| Chen, Q | 1 |
| Hirsch, LJ | 1 |
| Weintraub, D | 1 |
| Du, Y | 1 |
| Buchsbaum, R | 1 |
| Spencer, HT | 1 |
| Hager, M | 1 |
| Straka, T | 1 |
| Bazil, CW | 1 |
| Adams, DJ | 1 |
| Resor, SR | 1 |
| Morrell, MJ | 1 |
| Lyczkowski, DA | 1 |
| Pfeifer, HH | 1 |
| Ghosh, S | 1 |
| Thiele, EA | 1 |
| Jedrzejczak, J | 1 |
| Kuncíková, M | 1 |
| Magureanu, S | 1 |
| Gerstner, T | 1 |
| Bell, N | 1 |
| König, S | 1 |
| Wilder, BJ | 1 |
| Karas, BJ | 1 |
| Penry, JK | 1 |
| Asconape, J | 1 |
| Keränen, T | 1 |
| Sivenius, J | 1 |
| Schmidt, D | 1 |
| Koch-Weser, J | 1 |
| Browne, TR | 1 |
| Sherwood Brown, E | 1 |
| Shellhorn, E | 1 |
| Suppes, T | 1 |
| Zarate, CA | 1 |
| Narendran, R | 1 |
| Tomassini, EC | 1 |
| McDonald, J | 1 |
| Sederer, M | 1 |
| Madrid, AR | 1 |
| Faught, E | 1 |
| Morris, G | 1 |
| Jacobson, M | 1 |
| French, J | 1 |
| Harden, C | 1 |
| Montouris, G | 1 |
| Rosenfeld, W | 1 |
| Wagner, PG | 1 |
| Welton, SR | 1 |
| Hammond, CM | 1 |
| Alao, AO | 1 |
| Dewan, MJ | 1 |
| Deckers, CL | 1 |
| Hekster, YA | 1 |
| Keyser, A | 1 |
| van Lier, HJ | 1 |
| Meinardi, H | 1 |
| Renier, WO | 1 |
| Fröscher, W | 1 |
| Schulz, HU | 1 |
| Gugler, R | 1 |
| Gallassi, R | 1 |
| Williams, AJ | 1 |
| Evans-Jones, LG | 1 |
| Kindley, AD | 1 |
| Groom, PJ | 1 |
| Zaccara, G | 1 |
| Campostrini, R | 1 |
| Paganini, M | 1 |
| Messori, A | 1 |
| Valenza, T | 1 |
| Arnetoli, G | 1 |
| Zappoli, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study of Prophylactic Management of Lamotrigine for Bipolar Disorder in Pregnant Women[NCT03774641] | 20 participants (Anticipated) | Observational | 2018-12-03 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for valproic acid and Cholera Infantum
| Article | Year |
|---|---|
Recent advancements of bortezomib in acute lymphocytic leukemia treatment.
Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Drug Therapy, Combination; Fusion Proteins, bcr-ab | 2013 |
Correlating lamotrigine serum concentrations with tolerability in patients with epilepsy.
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Drug Eruptions; Drug Interactions; Drug Therapy, | 2004 |
Oral valproic acid for epilepsy--long-term experience in therapy and side effects.
Topics: Administration, Oral; Animals; Anticonvulsants; Epilepsy; Gastrointestinal Diseases; Humans; Pancrea | 2008 |
Drug therapy: Valproic acid.
Topics: Adult; Alopecia; Behavior; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Chil | 1980 |
4 trials available for valproic acid and Cholera Infantum
| Article | Year |
|---|---|
An observational study of first-line valproate monotherapy in focal epilepsy.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Brain Diseases; Child; Delayed-Action Preparations; | 2008 |
Drug therapy: Valproic acid.
Topics: Adult; Alopecia; Behavior; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Chil | 1980 |
Adding lamotrigine to valproate: incidence of rash and other adverse effects. Postmarketing Antiepileptic Drug Survey (PADS) Group.
Topics: Adolescent; Adult; Child; Dizziness; Drug Eruptions; Drug Hypersensitivity; Drug Therapy, Combinatio | 1999 |
Monotherapy versus polytherapy for epilepsy: a multicenter double-blind randomized study.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Cognition Disorders; Double-Blind Method; Drug Ad | 2001 |
16 other studies available for valproic acid and Cholera Infantum
| Article | Year |
|---|---|
Congenitally underdeveloped intestine drives autism-related gut microbiota and behavior.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Dysbiosis; Gastrointestinal Diseases; Gastroin | 2022 |
Translation of randomised controlled trial findings into clinical practice: comparison of olanzapine and valproate in the EMBLEM study.
Topics: Adult; Antidepressive Agents; Antimanic Agents; Benzodiazepines; Bipolar Disorder; Female; Gastroint | 2009 |
A 6-month prospective study on efficacy safety and QOL profiles of extended-release formulation of valproate in patients with epilepsy.
Topics: Adolescent; Adult; Aged; Chemistry, Pharmaceutical; Child; Delayed-Action Preparations; Epilepsy; Fe | 2011 |
[Valproate (depakine chrono) in adult patients with partial epilepsy: results of a multicentral prospective non-comparative study].
Topics: Adolescent; Adult; Anticonvulsants; Epilepsies, Partial; Female; Gastrointestinal Diseases; Humans; | 2012 |
Safety and tolerability of the ketogenic diet in pediatric epilepsy: effects of valproate combination therapy.
Topics: Acidosis; Anticonvulsants; Child; Child, Preschool; Combined Modality Therapy; Dietary Fats; Epileps | 2005 |
Gastrointestinal tolerance of divalproex sodium.
Topics: Adolescent; Adult; Child; Child, Preschool; Gastrointestinal Diseases; Humans; Middle Aged; Seizures | 1983 |
Side effects of carbamazepine, valproate and clonazepam during long-term treatment of epilepsy.
Topics: Abnormalities, Drug-Induced; Arousal; Benzodiazepinones; Carbamazepine; Chemical and Drug Induced Li | 1983 |
Adverse effects of valproate.
Topics: Gastrointestinal Diseases; Hematologic Diseases; Humans; Mental Disorders; Metabolic Diseases; Nervo | 1984 |
Gastrointestinal side-effects after switch to generic valproic acid.
Topics: Adult; Anticonvulsants; Female; Gastrointestinal Diseases; Humans; Therapeutic Equivalency; Valproic | 1998 |
The adverse effect profile and efficacy of divalproex sodium compared with valproic acid: a pharmacoepidemiology study.
Topics: Adolescent; Adult; Drug Therapy, Combination; Female; Gastrointestinal Diseases; Hospitalization; Hu | 1999 |
Gastrointestinal adverse effects with divalproex sodium and valproic acid.
Topics: Dose-Response Relationship, Drug; Gastrointestinal Diseases; Hospitalization; Humans; Incidence; Men | 2000 |
Evaluating the tolerability of the newer mood stabilizers.
Topics: Acetates; Amines; Anticonvulsants; Bipolar Disorder; Central Nervous System Diseases; Cyclohexanecar | 2001 |
[Antiepileptic therapy with valproinic acid. Correlations of side effects and serum levels of valproinic acid].
Topics: Acne Vulgaris; Anemia, Aplastic; Epilepsy; Fatigue; Gastrointestinal Diseases; Humans; Leukopenia; T | 1979 |
[Study of the therapeutic action and side-effects of a new preparation of dipropylacetic acid].
Topics: Adolescent; Adult; Child; Epilepsy; Female; Gastrointestinal Diseases; Humans; Male; Valerates; Valp | 1977 |
Sodium valproate in the prophylaxis of simple febrile convulsions.
Topics: Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Evaluation; Fever; Gastrointes | 1979 |
Long-term treatment with sodium valproate: monitoring of venous ammonia concentrations and adverse effects.
Topics: Adolescent; Adult; Alopecia; Ammonia; Body Weight; Child; Epilepsy; Female; Gastrointestinal Disease | 1987 |