valproic acid has been researched along with Child Mental Disorders in 10 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the general population, it is well established that periconceptual folic acid reduces the risk of neural tube defects (NTDs) and possibly other congenital abnormalities." | 5.05 | Valproate and folate: Congenital and developmental risks. ( Green, R; Reynolds, EH, 2020) |
| " Exposure to the antiepileptic drug valproic acid (VPA) during pregnancy significantly increases the risk of ASD in humans, and consequently is utilized as a validated animal model of ASD in rodents; however, the precise molecular and cellular mechanisms remain ill-defined." | 4.02 | Abnormal spatiotemporal expression pattern of progranulin and neurodevelopment impairment in VPA-induced ASD rat model. ( Chen, D; Hu, Y; Lan, J; Li, Y; Liao, A; Wang, S; Wang, X; Wang, Y; Yang, F; Zheng, W, 2021) |
| " A dose-response relationship was demonstrated and the risk of NDs was more particularly increased for an exposure to VPA during the second or third trimesters of pregnancy." | 1.56 | Risk of early neurodevelopmental disorders associated with in utero exposure to valproate and other antiepileptic drugs: a nationwide cohort study in France. ( Blotiere, PO; Coste, J; Dray-Spira, R; Mikaeloff, Y; Miranda, S; Peyre, H; Ramus, F; Weill, A; Zureik, M, 2020) |
| "Ataxia was observed in 7/34 cases." | 1.48 | Defining the phenotypic spectrum of SLC6A1 mutations. ( Abi-Warde, MT; Afenjar, A; Bird, LM; Carvill, GL; Chae, JH; Chelly, J; Choi, M; Christensen, J; Courage, C; Czapansky-Beilman, D; de Saint Martin, A; Devinsky, O; Doummar, D; Dubbs, H; Gardella, E; Gleeson, JG; Helbig, I; Helbig, KL; Hopkins, S; Johannesen, KM; Keren, B; Lehesjoki, AE; Lesca, G; Linnankivi, T; Mecarelli, O; Mefford, HC; Merritt, JL; Mignot, C; Millichap, JJ; Myers, CT; Møller, RS; Nava, C; Nespeca, M; Pal, DK; Pendziwiat, M; Pisani, L; Piton, A; Reichert, SC; Rodan, LH; Rubboli, G; Schaefer, E; Schelhaas, HJ; Shaw, JE; Specchio, N; Striano, P; Tan, WH; Tang, S; Trivisano, M; Verhoeven, JS; Weber, YG; Yoo, Y, 2018) |
| "Medulloblastoma is the most common malignant brain tumor in children." | 1.43 | Successful Use of Dose Dense Neoadjuvant Chemotherapy and Sodium Valproate with Minimal Toxicity in an Infant with Medulloblastoma in Extremely Poor General Condition. ( Abrari, A; Gupta, A; Kumar, A; Patir, R; Vaishya, S, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 4 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Reynolds, EH | 1 |
| Green, R | 1 |
| Coste, J | 1 |
| Blotiere, PO | 1 |
| Miranda, S | 1 |
| Mikaeloff, Y | 1 |
| Peyre, H | 1 |
| Ramus, F | 1 |
| Zureik, M | 1 |
| Weill, A | 1 |
| Dray-Spira, R | 1 |
| Brotzmann, K | 1 |
| Wolterbeek, A | 1 |
| Kroese, D | 1 |
| Braunbeck, T | 1 |
| Lan, J | 1 |
| Hu, Y | 1 |
| Wang, X | 1 |
| Zheng, W | 1 |
| Liao, A | 1 |
| Wang, S | 1 |
| Li, Y | 1 |
| Wang, Y | 1 |
| Yang, F | 1 |
| Chen, D | 1 |
| Gobshtis, N | 1 |
| Tfilin, M | 1 |
| Wolfson, M | 1 |
| Fraifeld, VE | 1 |
| Turgeman, G | 1 |
| Johannesen, KM | 1 |
| Gardella, E | 1 |
| Linnankivi, T | 1 |
| Courage, C | 1 |
| de Saint Martin, A | 1 |
| Lehesjoki, AE | 1 |
| Mignot, C | 1 |
| Afenjar, A | 1 |
| Lesca, G | 1 |
| Abi-Warde, MT | 1 |
| Chelly, J | 1 |
| Piton, A | 1 |
| Merritt, JL | 1 |
| Rodan, LH | 1 |
| Tan, WH | 1 |
| Bird, LM | 1 |
| Nespeca, M | 1 |
| Gleeson, JG | 1 |
| Yoo, Y | 1 |
| Choi, M | 1 |
| Chae, JH | 1 |
| Czapansky-Beilman, D | 1 |
| Reichert, SC | 1 |
| Pendziwiat, M | 1 |
| Verhoeven, JS | 1 |
| Schelhaas, HJ | 1 |
| Devinsky, O | 1 |
| Christensen, J | 1 |
| Specchio, N | 1 |
| Trivisano, M | 1 |
| Weber, YG | 1 |
| Nava, C | 1 |
| Keren, B | 1 |
| Doummar, D | 1 |
| Schaefer, E | 1 |
| Hopkins, S | 1 |
| Dubbs, H | 1 |
| Shaw, JE | 1 |
| Pisani, L | 1 |
| Myers, CT | 1 |
| Tang, S | 2 |
| Pal, DK | 1 |
| Millichap, JJ | 1 |
| Carvill, GL | 1 |
| Helbig, KL | 1 |
| Mecarelli, O | 1 |
| Striano, P | 1 |
| Helbig, I | 1 |
| Rubboli, G | 1 |
| Mefford, HC | 1 |
| Møller, RS | 1 |
| Olsen, DB | 1 |
| Baftiu, A | 1 |
| Kumar, P | 1 |
| Mohan, V | 1 |
| Sinha, RA | 1 |
| Chagtoo, M | 1 |
| Godbole, MM | 1 |
| Gupta, A | 1 |
| Kumar, A | 1 |
| Abrari, A | 1 |
| Patir, R | 1 |
| Vaishya, S | 1 |
| Zieminska, E | 1 |
| Lenart, J | 1 |
| Lazarewicz, JW | 1 |
1 review available for valproic acid and Child Mental Disorders
| Article | Year |
|---|---|
Valproate and folate: Congenital and developmental risks.
Topics: Anticonvulsants; Brain; Female; Folic Acid; Humans; Nervous System Malformations; Neural Tube Defect | 2020 |
9 other studies available for valproic acid and Child Mental Disorders
| Article | Year |
|---|---|
Risk of early neurodevelopmental disorders associated with in utero exposure to valproate and other antiepileptic drugs: a nationwide cohort study in France.
Topics: Adult; Anticonvulsants; Child, Preschool; Cohort Studies; Dose-Response Relationship, Drug; Epilepsy | 2020 |
Neurotoxic effects in zebrafish embryos by valproic acid and nine of its analogues: the fish-mouse connection?
Topics: Animals; Ecotoxicology; Embryo, Nonmammalian; Lethal Dose 50; Mice; Models, Biological; Morphogenesi | 2021 |
Abnormal spatiotemporal expression pattern of progranulin and neurodevelopment impairment in VPA-induced ASD rat model.
Topics: Animals; Anticonvulsants; Apoptosis; Autism Spectrum Disorder; Behavior, Animal; Brain; Disease Mode | 2021 |
Transplantation of mesenchymal stem cells reverses behavioural deficits and impaired neurogenesis caused by prenatal exposure to valproic acid.
Topics: Animals; Cell Differentiation; Disease Models, Animal; Doublecortin Protein; Female; GABA Agents; Hi | 2017 |
Defining the phenotypic spectrum of SLC6A1 mutations.
Topics: Adolescent; Adult; Anticonvulsants; Ataxia; Child; Child, Preschool; Cohort Studies; Electroencephal | 2018 |
Valproate is contraindicated in pregnancy.
Topics: Anticonvulsants; Contraindications, Drug; Epilepsy; Female; Humans; Neurodevelopmental Disorders; Pr | 2019 |
Histone deacetylase inhibition reduces hypothyroidism-induced neurodevelopmental defects in rats.
Topics: Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Cerebellum; Co-Repressor Proteins; Dis | 2015 |
Successful Use of Dose Dense Neoadjuvant Chemotherapy and Sodium Valproate with Minimal Toxicity in an Infant with Medulloblastoma in Extremely Poor General Condition.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cerebellar Neoplasms; Child; Child, Pre | 2016 |
Select putative neurodevelopmental toxins modify SNAP-25 expression in primary cultures of rat cerebellar granule cells.
Topics: Animals; Cells, Cultured; Cerebellum; Exocytosis; Gene Expression Regulation; Metal Nanoparticles; N | 2016 |