valproic acid has been researched along with Chemical and Drug Induced Liver Injury, Chronic in 6 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical and Drug Induced Liver Injury, Chronic: Liver disease lasting six months or more, caused by an adverse effect of a drug or chemical. The adverse effect may be caused by drugs, drug metabolites, chemicals from the environment, or an idiosyncratic response.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid (VPA) is an anti-seizure drug that causes idiosyncratic liver injury." | 2.82 | Valproic acid induced liver injury: An insight into molecular toxicological mechanism. ( Ezhilarasan, D; Mani, U, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 5 (83.33) | 2.80 |
| Authors | Studies |
|---|---|
| Gheena, S | 1 |
| Ezhilarasan, D | 2 |
| Shree Harini, K | 1 |
| Rajeshkumar, S | 1 |
| Mani, U | 1 |
| Pirozzi, C | 1 |
| Lama, A | 1 |
| Annunziata, C | 1 |
| Cavaliere, G | 1 |
| De Caro, C | 1 |
| Citraro, R | 1 |
| Russo, E | 1 |
| Tallarico, M | 1 |
| Iannone, M | 1 |
| Ferrante, MC | 1 |
| Mollica, MP | 1 |
| Mattace Raso, G | 1 |
| De Sarro, G | 1 |
| Calignano, A | 1 |
| Meli, R | 1 |
| Mohammed, MA | 1 |
| Gharib, DM | 1 |
| Reyad, HR | 1 |
| Mohamed, AA | 1 |
| Elroby, FA | 1 |
| Mahmoud, HS | 1 |
| Celik, E | 1 |
| Tunali, S | 1 |
| Gezginci-Oktayoglu, S | 1 |
| Bolkent, S | 1 |
| Can, A | 1 |
| Yanardag, R | 1 |
| Kolts, BE | 1 |
| Langfitt, M | 1 |
1 review available for valproic acid and Chemical and Drug Induced Liver Injury, Chronic
| Article | Year |
|---|---|
Valproic acid induced liver injury: An insight into molecular toxicological mechanism.
Topics: Adenosine Triphosphate; Ammonia; Anticonvulsants; Carnitine O-Palmitoyltransferase; Chemical and Dru | 2022 |
5 other studies available for valproic acid and Chemical and Drug Induced Liver Injury, Chronic
| Article | Year |
|---|---|
Syringic acid and silymarin concurrent administration inhibits sodium valproate-induced liver injury in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Chemical and Drug Induced Liver Injury; Chemical an | 2022 |
Butyrate prevents valproate-induced liver injury: In vitro and in vivo evidence.
Topics: Anticonvulsants; Butyric Acid; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liv | 2020 |
Antioxidant and anti-inflammatory properties of alpha-lipoic acid protect against valproic acid-induced liver injury.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury, Chronic; Male; Rats; Thioctic Acid; V | 2021 |
Vitamin U prevents valproic acid-induced liver injury through supporting enzymatic antioxidant system and increasing hepatocyte proliferation triggered by inflammation and apoptosis.
Topics: Animals; Antioxidants; Apoptosis; Cell Proliferation; Chemical and Drug Induced Liver Injury, Chroni | 2021 |
Drugs and the liver.
Topics: Acetaminophen; Adult; Aspirin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liv | 1984 |