valproic acid has been researched along with Cerebral Palsy in 19 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Cerebral Palsy: A heterogeneous group of nonprogressive motor disorders caused by chronic brain injuries that originate in the prenatal period, perinatal period, or first few years of life. The four major subtypes are spastic, athetoid, ataxic, and mixed cerebral palsy, with spastic forms being the most common. The motor disorder may range from difficulties with fine motor control to severe spasticity (see MUSCLE SPASTICITY) in all limbs. Spastic diplegia (Little disease) is the most common subtype, and is characterized by spasticity that is more prominent in the legs than in the arms. Pathologically, this condition may be associated with LEUKOMALACIA, PERIVENTRICULAR. (From Dev Med Child Neurol 1998 Aug;40(8):520-7)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We describe a case of a 31-year-old woman with cerebral palsy who developed fatal acute hemorrhagic pancreatitis while being treated with valproic acid to control her seizure activity." | 8.79 | Fatal acute pancreatitis caused by valproic acid. ( Evans, RJ; Jordan, J; Krolikowski, FJ; Miranda, RN, 1995) |
| "We describe a case of a 31-year-old woman with cerebral palsy who developed fatal acute hemorrhagic pancreatitis while being treated with valproic acid to control her seizure activity." | 4.79 | Fatal acute pancreatitis caused by valproic acid. ( Evans, RJ; Jordan, J; Krolikowski, FJ; Miranda, RN, 1995) |
| " A cohort study comparing life expectancy of males and females with cerebral palsy and a systematic review of five trials comparing two anti-epileptic drugs, carbamazepine and sodium valproate, are used for illustration." | 3.71 | Aggregate data meta-analysis with time-to-event outcomes. ( Hutton, JL; Marson, AG; Smith, CT; Williamson, PR, 2002) |
| "We describe arginase deficiency in a 20-year-old woman with spastic paraplegia, progressive dystonia, dementia, peripheral neuropathy, epilepsy, liver cirrhosis, and non-B/non-C hepatocellular carcinoma." | 1.38 | Arginase deficiency with new phenotype and a novel mutation: contemporary summary. ( Ching, CK; Fung, CW; Lam, CW; Luk, HM; Mak, CM; Poon, WL; Siu, TS; Tam, S; Tsang, JP; Wong, VC, 2012) |
| "Epilepsy is one of the most frequent neurological diseases in the pediatric population." | 1.36 | [Characteristics of the children with epilepsy followed in the Marrakech University Hospital]. ( Amine, M; Bourrous, M; Bouskraoui, M; Draiss, G; Elibrahimi, I; Safini, F, 2010) |
| "A child with dyskinetic cerebral palsy who had been on sodium valproate for several years was transferred for drainage of a left sided pleural effusion." | 1.35 | Fungal pleural effusion secondary to a rare cause of pancreatic pseudocyst. ( Bush, A; Clarke, S; Gupta, A; Marrs, T; Rosenthal, M; Urquhart, D, 2009) |
| "Total remission of seizures occurred in 52%." | 1.30 | Long-term outcomes of conventional therapy for infantile spasms. ( Clarke, SL; Griesemer, DA; Holden, KR, 1997) |
| "EEG showed typical hypsarrhythmia in 8 cases, asymmetrical hypsarrhythmia in 1 case and modified hypsarrhythmia in another case." | 1.30 | [West's syndrome in patients with cerebral paralysis and periventricular leukomalacia: a good response to treatment]. ( Caraballo, R; Cersósimo, R; Fejerman, N; Intruvini, S; Pociecha, J, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.26) | 18.7374 |
| 1990's | 5 (26.32) | 18.2507 |
| 2000's | 5 (26.32) | 29.6817 |
| 2010's | 8 (42.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Khakwani, A | 1 |
| Gannon, D | 1 |
| Awa, HD | 1 |
| Chelo, D | 1 |
| Kinkela, MN | 1 |
| Ndombo, PO | 1 |
| Weiner, D | 1 |
| Nir, V | 1 |
| Klein-Kremer, A | 1 |
| Kassem, E | 1 |
| Martínez-Rivera, V | 1 |
| Martínez-Antón, J | 1 |
| Gupta, A | 1 |
| Marrs, T | 1 |
| Urquhart, D | 1 |
| Clarke, S | 1 |
| Rosenthal, M | 1 |
| Bush, A | 1 |
| Bourrous, M | 1 |
| Elibrahimi, I | 1 |
| Draiss, G | 1 |
| Safini, F | 1 |
| Amine, M | 1 |
| Bouskraoui, M | 1 |
| De Rinaldis, M | 1 |
| Gennaro, L | 1 |
| Losito, L | 1 |
| Trabacca, A | 1 |
| Tsang, JP | 1 |
| Poon, WL | 1 |
| Luk, HM | 1 |
| Fung, CW | 1 |
| Ching, CK | 1 |
| Mak, CM | 1 |
| Lam, CW | 1 |
| Siu, TS | 1 |
| Tam, S | 1 |
| Wong, VC | 1 |
| Ohtaki, U | 1 |
| Ozawa, H | 1 |
| Ishizuka, T | 1 |
| Kamiishi, A | 1 |
| Sasaki, K | 1 |
| Nakajima, S | 1 |
| Katayama, A | 1 |
| Arimoto, K | 1 |
| Yagihashi, T | 1 |
| Kimiya, S | 1 |
| Gesundheit, B | 1 |
| Kirby, M | 1 |
| Lau, W | 1 |
| Koren, G | 1 |
| Abdelhaleem, M | 1 |
| Williamson, PR | 1 |
| Smith, CT | 1 |
| Hutton, JL | 1 |
| Marson, AG | 1 |
| Jaseja, H | 1 |
| Kakinuma, H | 1 |
| Fujiki, T | 1 |
| Nakamura, T | 1 |
| Takahashi, H | 1 |
| Evans, RJ | 1 |
| Miranda, RN | 1 |
| Jordan, J | 1 |
| Krolikowski, FJ | 1 |
| Winter, SL | 1 |
| Kriel, RL | 1 |
| Novacheck, TF | 1 |
| Luxenberg, MG | 1 |
| Leutgeb, VJ | 1 |
| Erickson, PA | 1 |
| Holden, KR | 1 |
| Clarke, SL | 1 |
| Griesemer, DA | 1 |
| Caraballo, R | 1 |
| Cersósimo, R | 1 |
| Intruvini, S | 1 |
| Pociecha, J | 1 |
| Fejerman, N | 1 |
| Murakami, K | 1 |
| Sugimoto, T | 1 |
| Nishida, N | 1 |
| Kobayashi, Y | 1 |
| Kuhara, T | 1 |
| Matsumoto, I | 1 |
| Rodriguez-Segade, S | 1 |
| de la Peña, CA | 1 |
| Tutor, JC | 1 |
| Paz, JM | 1 |
| Fernandez, MP | 1 |
| Rozas, I | 1 |
| Del Río, R | 1 |
4 reviews available for valproic acid and Cerebral Palsy
| Article | Year |
|---|---|
L-carnitine supplementation as a potential therapy for suspected hyperammonaemic encephalopathy.
Topics: Adult; Anticonvulsants; Blood Chemical Analysis; Carnitine; Cerebral Palsy; Dietary Supplements; Epi | 2019 |
Treatment of interictal epileptiform discharges in cerebral palsy patients without clinical epilepsy: hope for a better outcome in prognosis.
Topics: Calcium Channels; Cerebral Palsy; Electroencephalography; Epilepsy; Glutamic Acid; Humans; Intracell | 2007 |
Fatal acute pancreatitis caused by valproic acid.
Topics: Acute Disease; Adult; Cerebral Palsy; Fatal Outcome; Female; Humans; Pancreatitis; Seizures; Valproi | 1995 |
Perioperative blood loss: the effect of valproate.
Topics: Adolescent; Blood Component Transfusion; Blood Loss, Surgical; Blood Transfusion; Cerebral Palsy; Ch | 1996 |
15 other studies available for valproic acid and Cerebral Palsy
| Article | Year |
|---|---|
[Patent rickets disclosed by loss of convulsion control in a boy with cerebral palsy].
Topics: Anticonvulsants; Calcium; Carbamazepine; Cerebral Palsy; Child, Preschool; Diazepam; Epilepsy; Human | 2013 |
Chronic valproic acid intoxication.
Topics: Anticonvulsants; Cerebral Palsy; Chemistry, Pharmaceutical; Child; Chronic Disease; Developmental Di | 2013 |
[Hyperekplexia associated to precocious puberty].
Topics: Anticonvulsants; Benzodiazepines; Cerebral Palsy; Child; Clobazam; Drug Therapy, Combination; Electr | 2015 |
Fungal pleural effusion secondary to a rare cause of pancreatic pseudocyst.
Topics: Anticonvulsants; Candida glabrata; Candidiasis; Cerebral Palsy; Child, Preschool; Female; Humans; Ia | 2009 |
[Characteristics of the children with epilepsy followed in the Marrakech University Hospital].
Topics: Adolescent; Age of Onset; Anticonvulsants; Cerebral Palsy; Child; Child, Preschool; Consanguinity; E | 2010 |
Drug-to-drug interaction between sodium valproate and trihexyphenidyl in a child with extrapyramidal cerebral palsy and epilepsy.
Topics: Anticonvulsants; Cerebral Palsy; Child, Preschool; Dose-Response Relationship, Drug; Drug Interactio | 2011 |
Arginase deficiency with new phenotype and a novel mutation: contemporary summary.
Topics: Anticonvulsants; Arginase; Base Sequence; Carcinoma, Hepatocellular; Cerebral Palsy; Codon, Nonsense | 2012 |
[Evaluation of serum total carnitine values in persons with severe motor and intellectual disabilities with enteral (tube) feeding].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Carnitine; Cerebral Palsy; Chromosome Aberrations; Disab | 2012 |
Thrombocytopenia and megakaryocyte dysplasia: an adverse effect of valproic acid treatment.
Topics: Blood Platelets; Bone Marrow; Cerebral Palsy; Child; Female; Humans; Megakaryocytes; Thrombocytopeni | 2002 |
Aggregate data meta-analysis with time-to-event outcomes.
Topics: Anticonvulsants; Carbamazepine; Cerebral Palsy; Cohort Studies; Epilepsy; Female; Humans; Life Table | 2002 |
Valproate hepatotoxicity in a 5-year-old boy with cerebral palsy due to neonatal asphyxia.
Topics: Anticonvulsants; Asphyxia Neonatorum; Cerebral Palsy; Child, Preschool; Echovirus Infections; Enceph | 2006 |
Long-term outcomes of conventional therapy for infantile spasms.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Cerebral Palsy; Cognition Disorders; Female; Humans; I | 1997 |
[West's syndrome in patients with cerebral paralysis and periventricular leukomalacia: a good response to treatment].
Topics: Anticonvulsants; Atrophy; Cerebral Palsy; Cerebral Ventricles; Child; Child, Preschool; Female; gamm | 1997 |
Abnormal metabolism of carnitine and valproate in a case of acute encephalopathy during chronic valproate therapy.
Topics: Brain Diseases; Carnitine; Cerebral Palsy; Child; Chronic Disease; Female; Gas Chromatography-Mass S | 1992 |
Carnitine deficiency associated with anticonvulsant therapy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Carnitine; Cerebral Palsy; Drug Therapy, Co | 1989 |