valproic acid has been researched along with Cerebellar Ataxia in 10 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Cerebellar Ataxia: Incoordination of voluntary movements that occur as a manifestation of CEREBELLAR DISEASES. Characteristic features include a tendency for limb movements to overshoot or undershoot a target (dysmetria), a tremor that occurs during attempted movements (intention TREMOR), impaired force and rhythm of diadochokinesis (rapidly alternating movements), and GAIT ATAXIA. (From Adams et al., Principles of Neurology, 6th ed, p90)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Reversible dystonia may occasionally be precipitated by phenytoin or carbamazepine; asterixis by phenytoin, barbiturates or carbamazepine; and, more commonly, tremor by valproate." | 4.77 | Adverse neuropsychiatric effects of anticonvulsant drugs. ( Reynolds, EH; Trimble, MR, 1985) |
| "Treatment of chronic daily headache/transformed migraine is challenging, especially when it is complicated by overuse of analgesics, triptans, or both." | 2.70 | Intravenous valproate sodium in the treatment of daily headache. ( Karpitskiy, VV; Schwartz, TH; Sohn, RS, 2002) |
| "Carbamazepine (CBZ) was found to be effective in most cases." | 2.61 | Epilepsy in patients with EAST syndrome caused by mutation in the KCNJ10. ( Albaradie, R; Alhazmi, R; Alkhaldi, H; Chaudhary, M; Housawi, Y; Mir, A, 2019) |
| "Even though Epilepsy is a significant clinical issue in ATP1A3 patients, only a minority of publications provide any information about patients' anti-epileptic treatment." | 1.56 | ATP1A3-related epilepsy: Report of seven cases and literature-based analysis of treatment response. ( Abicht, A; Biskup, S; Boonsimma, P; Borggraefe, I; Gasser, M; Ittiwut, C; Krenn, M; Kuersten, M; Milenkovic, I; Netbaramee, W; Roser, T; Shotelersuk, V; Srichomthomg, C; Suphapeetiporn, K; Tacke, M; von Stülpnagel, C; Wagner, M; Wechapinan, T; Zimprich, F, 2020) |
| " The observed cerebellar ataxia might be due to long-term administration of phenytoin." | 1.35 | [Case of juvenile myoclonic epilepsy misdiagnosed as simple partial seizure for more than 60 years]. ( Komori, T; Mizoi, Y; Shimazu, K; Sumita, N; Tamura, N; Yamamoto, T, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gasser, M | 1 |
| Boonsimma, P | 1 |
| Netbaramee, W | 1 |
| Wechapinan, T | 1 |
| Srichomthomg, C | 1 |
| Ittiwut, C | 1 |
| Krenn, M | 1 |
| Zimprich, F | 1 |
| Milenkovic, I | 1 |
| Abicht, A | 1 |
| Biskup, S | 1 |
| Roser, T | 1 |
| Shotelersuk, V | 1 |
| Tacke, M | 1 |
| Kuersten, M | 1 |
| Wagner, M | 1 |
| Borggraefe, I | 1 |
| Suphapeetiporn, K | 1 |
| von Stülpnagel, C | 1 |
| Mir, A | 1 |
| Chaudhary, M | 1 |
| Alkhaldi, H | 1 |
| Alhazmi, R | 1 |
| Albaradie, R | 1 |
| Housawi, Y | 1 |
| Mizoi, Y | 1 |
| Sumita, N | 1 |
| Yamamoto, T | 1 |
| Komori, T | 1 |
| Tamura, N | 1 |
| Shimazu, K | 1 |
| Schwartz, TH | 1 |
| Karpitskiy, VV | 1 |
| Sohn, RS | 1 |
| Somerville, ER | 1 |
| Olanow, CW | 1 |
| Ranjan, S | 1 |
| Jagadheesan, K | 1 |
| Nizamie, SH | 1 |
| Legg, N | 1 |
| Girard, PL | 1 |
| Papy, JJ | 1 |
| Dumas, M | 1 |
| Sobaniec, W | 1 |
| Jankowicz, E | 1 |
| Sobaniec-Lotowska, M | 1 |
| Reynolds, EH | 1 |
| Trimble, MR | 1 |
2 reviews available for valproic acid and Cerebellar Ataxia
| Article | Year |
|---|---|
Epilepsy in patients with EAST syndrome caused by mutation in the KCNJ10.
Topics: Anticonvulsants; Brain; Carbamazepine; Cerebellar Ataxia; Child; Child, Preschool; Epilepsy; Female; | 2019 |
Adverse neuropsychiatric effects of anticonvulsant drugs.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Barbiturates; Benzodiazepines; Biogenic Amines; Carba | 1985 |
1 trial available for valproic acid and Cerebellar Ataxia
| Article | Year |
|---|---|
Intravenous valproate sodium in the treatment of daily headache.
Topics: Adolescent; Adult; Analgesics; Cerebellar Ataxia; Chronic Disease; Dose-Response Relationship, Drug; | 2002 |
7 other studies available for valproic acid and Cerebellar Ataxia
| Article | Year |
|---|---|
ATP1A3-related epilepsy: Report of seven cases and literature-based analysis of treatment response.
Topics: Adult; Anticonvulsants; Cerebellar Ataxia; Child; Dystonic Disorders; Epilepsy; Female; Hearing Loss | 2020 |
[Case of juvenile myoclonic epilepsy misdiagnosed as simple partial seizure for more than 60 years].
Topics: Aged; Cerebellar Ataxia; Diagnostic Errors; Electroencephalography; Electromyography; Epilepsies, Pa | 2009 |
Valproic acid. Treatment of myoclonus in dyssynergia cerebellaris myoclonica.
Topics: Adult; Cerebellar Ataxia; Female; Humans; Myoclonic Cerebellar Dyssynergia; Myoclonus; Valproic Acid | 1982 |
Cerebellar ataxia with intravenous valproate and haloperidol.
Topics: Adult; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Cerebellar Ataxia; Haloperidol; Hum | 2002 |
Oral choline in cerebellar ataxia.
Topics: Baclofen; Cerebellar Ataxia; Choline; Humans; Valproic Acid | 1979 |
[Myoclonic cerebellar dyssynergia with epilepsy (Ramsey-Hunt syndrome). Electro-clinical study in a patient of the black race].
Topics: Adult; Black People; Cerebellar Ataxia; Electroencephalography; Epilepsy; Female; Humans; Phenobarbi | 1975 |
Effect of valproic acid on the morphology of the rat cerebellum and brain stem.
Topics: Animals; Brain Stem; Cerebellar Ataxia; Cerebellum; Dose-Response Relationship, Drug; Male; Purkinje | 1989 |