valproic acid has been researched along with Cephalgia Syndromes in 12 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Among headache types, unclassifiable chronic headache segregated from all other classified headaches in terms of poor response." | 2.71 | Treatment of primary headache disorders with intravenous valproate: initial outpatient experience. ( Rybicki, LA; Stillman, MJ; Zajac, D, 2004) |
| "Treatment of chronic daily headache/transformed migraine is challenging, especially when it is complicated by overuse of analgesics, triptans, or both." | 2.70 | Intravenous valproate sodium in the treatment of daily headache. ( Karpitskiy, VV; Schwartz, TH; Sohn, RS, 2002) |
| " There were no serious adverse events." | 1.72 | Efficacy and Safety of Repetitive Intravenous Sodium Valproate in Pediatric Patients With Refractory Chronic Headache Disorders: A Retrospective Review. ( Allen, I; Gelfand, AA; Pavitt, S; Riggins, N; Zorrilla, N, 2022) |
| "Topiramate was more likely prescribed for those with comorbid headache or migraine (incident: 335 of 1251 [26." | 1.51 | Antiepileptic Drug Treatment Patterns in Women of Childbearing Age With Epilepsy. ( Faught, E; Fishman, J; Kalilani, L; Kim, H; Thurman, DJ, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (83.33) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Pavitt, S | 1 |
| Gelfand, AA | 1 |
| Zorrilla, N | 1 |
| Allen, I | 1 |
| Riggins, N | 1 |
| Kim, H | 1 |
| Faught, E | 1 |
| Thurman, DJ | 1 |
| Fishman, J | 1 |
| Kalilani, L | 1 |
| Lambru, G | 1 |
| Castellini, P | 1 |
| Bini, A | 1 |
| Evangelista, A | 1 |
| Manzoni, GC | 1 |
| Torelli, P | 1 |
| Friedman, BW | 1 |
| Grosberg, BM | 1 |
| Schwartz, TH | 1 |
| Karpitskiy, VV | 1 |
| Sohn, RS | 1 |
| Stillman, MJ | 1 |
| Zajac, D | 1 |
| Rybicki, LA | 1 |
| Coskun, O | 1 |
| Ucler, S | 1 |
| Cavdar, L | 1 |
| Inan, LE | 1 |
| D'Amico, D | 1 |
| Pascual, J | 1 |
| Cacabelos, P | 1 |
| Yurekli, VA | 1 |
| Akhan, G | 1 |
| Kutluhan, S | 1 |
| Uzar, E | 1 |
| Koyuncuoglu, HR | 1 |
| Gultekin, F | 1 |
| Freitag, FG | 1 |
| Diamond, S | 1 |
| Diamond, ML | 1 |
| Urban, GJ | 1 |
| Robbins, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Oxygen Therapy in Primary Headache Disorder[NCT05511155] | 132 participants (Actual) | Observational | 2022-07-01 | Completed | |||
| Therapeutic Management of Acute Cephalalgia Before and After Use of a Therapeutic Protocol in Emergency Department[NCT02236442] | 200 participants (Actual) | Interventional | 2014-10-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for valproic acid and Cephalgia Syndromes
| Article | Year |
|---|---|
Diagnosis and management of the primary headache disorders in the emergency department setting.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Dihydroergotamine; Dop | 2009 |
Diagnosis and management of the primary headache disorders in the emergency department setting.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Dihydroergotamine; Dop | 2009 |
Diagnosis and management of the primary headache disorders in the emergency department setting.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Dihydroergotamine; Dop | 2009 |
Diagnosis and management of the primary headache disorders in the emergency department setting.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Dihydroergotamine; Dop | 2009 |
Antiepileptic drugs in the prophylaxis of migraine, chronic headache forms and cluster headache: a review of their efficacy and tolerability.
Topics: Anticonvulsants; Clinical Trials as Topic; Cluster Headache; Drug Resistance; Fructose; Headache Dis | 2007 |
3 trials available for valproic acid and Cephalgia Syndromes
| Article | Year |
|---|---|
Intravenous valproate sodium in the treatment of daily headache.
Topics: Adolescent; Adult; Analgesics; Cerebellar Ataxia; Chronic Disease; Dose-Response Relationship, Drug; | 2002 |
Treatment of primary headache disorders with intravenous valproate: initial outpatient experience.
Topics: Adolescent; Adult; Aged; Ambulatory Care; Cluster Headache; Female; Headache Disorders; Humans; Infu | 2004 |
The effect of sodium valproate on chronic daily headache and its subgroups.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Chronic Disease; Double-Blind Method; Female; Headache Dis | 2008 |
7 other studies available for valproic acid and Cephalgia Syndromes
| Article | Year |
|---|---|
Efficacy and Safety of Repetitive Intravenous Sodium Valproate in Pediatric Patients With Refractory Chronic Headache Disorders: A Retrospective Review.
Topics: Adolescent; Age Factors; Child; Child, Preschool; Chronic Disease; Female; GABA Agents; Headache Dis | 2022 |
Antiepileptic Drug Treatment Patterns in Women of Childbearing Age With Epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Anxiety Disorders; Comorbidity; Dissociative Disorders; Epilepsi | 2019 |
Hemicrania continua evolving from cluster headache responsive to valproic acid.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Depression; Dyspepsia; Female; GABA Agents; Gastritis; Head | 2008 |
Effect of valproic acid on withdrawal therapy in patients with overuse of chronic daily headache medications.
Topics: Adult; Aged; Analgesics; Chronic Disease; Female; GABA Agents; Headache Disorders; Humans; Male; Mid | 2007 |
More lessons for the treatment of chronic daily headache.
Topics: Adrenergic beta-Antagonists; Analgesics; Anticonvulsants; Clinical Protocols; Clinical Trials as Top | 2008 |
Divalproex in the long-term treatment of chronic daily headache.
Topics: Adult; Body Weight; Female; Headache Disorders; Humans; Male; Migraine Disorders; Retrospective Stud | 2001 |
We need better preventative medications.
Topics: Antidepressive Agents, Tricyclic; Chronic Disease; Headache Disorders; Humans; Selective Serotonin R | 2001 |