valproic acid has been researched along with Central Nervous System Syphilis in 3 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We encountered catatonia in a man with neurosyphilis after increasing aripiprazole and valproate (drugs reported to improve catatonia) and reducing doxycycline and temazepam dosages, consistent with identified dopamine D2, serotonin 5HT2, and 5HT1a (aripiprazole), GABA-B (valproate), glutamatergic NMDA (aripiprazole, valproate, doxycycline), and GABA-A (aripiprazole, temazepam) mechanisms of catatonia." | 3.75 | Catatonia and CPK elevation in neurosyphilis: role of plural pharmacodynamic mechanisms. ( Carter, WG; Lauterbach, EC; Norris, BK; Shillcutt, SD, 2009) |
| "We diagnosed this case as Lissauer's general paresis and treated with intravenous benzylpenicillin potassium 24 million units per day for 2 weeks." | 1.36 | [A case of Lissauer form of paretic neurosyphilis with drop attacks and dementia]. ( Arahata, S; Araki, E; Fujii, N; Furuya, H; Syouzaki, T, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lauterbach, EC | 1 |
| Norris, BK | 1 |
| Carter, WG | 1 |
| Shillcutt, SD | 1 |
| Syouzaki, T | 1 |
| Arahata, S | 1 |
| Araki, E | 1 |
| Furuya, H | 1 |
| Fujii, N | 1 |
| Adeva Bartolomé, MT | 1 |
| Zurdo Hernández, JM | 1 |
| Hernández Bayo, JM | 1 |
3 other studies available for valproic acid and Central Nervous System Syphilis
| Article | Year |
|---|---|
Catatonia and CPK elevation in neurosyphilis: role of plural pharmacodynamic mechanisms.
Topics: Adult; Aripiprazole; Catatonia; Creatine Kinase; Dose-Response Relationship, Drug; Doxycycline; Huma | 2009 |
[A case of Lissauer form of paretic neurosyphilis with drop attacks and dementia].
Topics: Dementia; Humans; Male; Middle Aged; Neurosyphilis; Syncope; Valproic Acid | 2010 |
[Meningovascular neurosyphilis].
Topics: Adult; Anti-Bacterial Agents; Brain; Electroencephalography; Humans; Magnetic Resonance Imaging; Mal | 2007 |