valproic acid has been researched along with Central Nervous System Neoplasm in 3 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Su, JM | 1 |
| Li, XN | 1 |
| Thompson, P | 1 |
| Ou, CN | 1 |
| Ingle, AM | 1 |
| Russell, H | 1 |
| Lau, CC | 1 |
| Adamson, PC | 1 |
| Blaney, SM | 1 |
| Morikawa, N | 2 |
| Mori, T | 2 |
| Kawashima, H | 2 |
| Takeyama, M | 2 |
| Hori, S | 2 |
| Abe, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase I Study of Valproic Acid in Children With Recurrent/Progressive Solid Tumors Including CNS Tumors[NCT00107458] | Phase 1 | 26 participants (Actual) | Interventional | 2005-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for valproic acid and Central Nervous System Neoplasm
| Article | Year |
|---|---|
Phase 1 study of valproic acid in pediatric patients with refractory solid or CNS tumors: a children's oncology group report.
Topics: Acylation; Adolescent; Central Nervous System Neoplasms; Child; Child, Preschool; Drug Resistance, N | 2011 |
2 other studies available for valproic acid and Central Nervous System Neoplasm
| Article | Year |
|---|---|
Change of valproic acid concentrations during cerebrospinal fluid perfusion chemotherapy.
Topics: Adult; Anticonvulsants; Central Nervous System Neoplasms; Chemotherapy, Cancer, Regional Perfusion; | 2000 |
Pharmacokinetics of cytosine arabinoside, methotrexate, nimustine and valproic acid in cerebrospinal fluid during cerebrospinal fluid perfusion chemotherapy.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Combined Mo | 2000 |