valproic acid has been researched along with Central Nervous System Disease in 8 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The mood stabilizers lithium and valproic acid (VPA) are traditionally used to treat bipolar disorder (BD), a severe mental illness arising from complex interactions between genes and environment that drive deficits in cellular plasticity and resiliency." | 8.89 | Therapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorder. ( Chiu, CT; Chuang, DM; Hunsberger, JG; Wang, Z, 2013) |
| "The mood stabilizers lithium and valproic acid (VPA) are traditionally used to treat bipolar disorder (BD), a severe mental illness arising from complex interactions between genes and environment that drive deficits in cellular plasticity and resiliency." | 4.89 | Therapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorder. ( Chiu, CT; Chuang, DM; Hunsberger, JG; Wang, Z, 2013) |
| "A case of valproic acid poisoning with coma and neurological sequelae is presented." | 3.67 | Neurological sequelae after intoxication with sodium valproate. ( Bigler, D, 1985) |
| "Mood disorders have traditionally been conceptualized as neurochemical disorders, but there is now evidence from a variety of sources demonstrating regional reductions in central nervous system (CNS) volume, as well as reductions in the numbers and/or sizes of glia and neurons in discrete brain areas." | 2.42 | The use of mood stabilizers as plasticity enhancers in the treatment of neuropsychiatric disorders. ( Du, J; Gray, NA; Manji, HK; Moore, GJ; Zhou, R, 2003) |
| "Mild signs of HPNS (e." | 1.28 | Sodium valproate interactions with the HPNS: EEG and behavioral observations. ( Clarke, D; Doré, CJ; Halsey, MJ; Luff, NP; Maclean, CJ; Pearce, PC, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chiu, CT | 1 |
| Wang, Z | 1 |
| Hunsberger, JG | 1 |
| Chuang, DM | 1 |
| Gray, NA | 1 |
| Zhou, R | 1 |
| Du, J | 1 |
| Moore, GJ | 1 |
| Manji, HK | 1 |
| Zaccara, G | 1 |
| Franciotta, D | 1 |
| Perucca, E | 1 |
| Alao, AO | 1 |
| Dewan, MJ | 1 |
| Pearce, PC | 1 |
| Clarke, D | 1 |
| Doré, CJ | 1 |
| Halsey, MJ | 2 |
| Luff, NP | 1 |
| Maclean, CJ | 1 |
| Lipsky, MS | 1 |
| Rostain, JC | 1 |
| Wardley-Smith, B | 1 |
| Forni, C | 1 |
| Bigler, D | 1 |
3 reviews available for valproic acid and Central Nervous System Disease
| Article | Year |
|---|---|
Therapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorder.
Topics: Animals; Antimanic Agents; Bipolar Disorder; Central Nervous System Diseases; Humans; Lithium Compou | 2013 |
The use of mood stabilizers as plasticity enhancers in the treatment of neuropsychiatric disorders.
Topics: Anticonvulsants; Apoptosis; Atrophy; Brain; Central Nervous System Diseases; Gene Expression; Genes, | 2003 |
Idiosyncratic adverse reactions to antiepileptic drugs.
Topics: Age Factors; Anemia, Aplastic; Anticonvulsants; B-Lymphocytes; Central Nervous System Diseases; Chem | 2007 |
5 other studies available for valproic acid and Central Nervous System Disease
| Article | Year |
|---|---|
Evaluating the tolerability of the newer mood stabilizers.
Topics: Acetates; Amines; Anticonvulsants; Bipolar Disorder; Central Nervous System Diseases; Cyclohexanecar | 2001 |
Sodium valproate interactions with the HPNS: EEG and behavioral observations.
Topics: Animals; Central Nervous System Diseases; Electroencephalography; Female; High Pressure Neurological | 1989 |
Chronic hiccups.
Topics: Adult; Anticonvulsants; Central Nervous System Diseases; Chronic Disease; Diabetes Complications; Fe | 1986 |
Gamma-aminobutyric acid and the high pressure neurological syndrome.
Topics: Alanine; Aminobutyrates; Animals; Atmospheric Pressure; Central Nervous System Diseases; Electrodes, | 1986 |
Neurological sequelae after intoxication with sodium valproate.
Topics: Adult; Central Nervous System Diseases; Coma; Humans; Male; Valproic Acid | 1985 |