valproic acid has been researched along with Cell Transformation, Neoplastic in 11 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We have used several models of PML-RARA-driven acute promyelocytic leukemias (APLs) to analyze the in vivo effects of valproic acid, a well-characterized HDACis." | 3.78 | Valproic acid induces differentiation and transient tumor regression, but spares leukemia-initiating activity in mouse models of APL. ( Dal Zuffo, R; de Thé, H; Leiva, M; Mercurio, C; Minucci, S; Moretti, S; Pallavicini, I; Peres, L; Soilihi, H, 2012) |
| "Bladder cancer is one of the most common malignancies and causes hundreds of thousands of deaths worldwide each year." | 1.37 | Histone deacetylases (HDACs) in XPC gene silencing and bladder cancer. ( Abrams, J; Wang, G; Wang, L; Xu, XS, 2011) |
| "Valproic acid (VPA) is a promising anticancer agent recently assigned to the class of histone deacetylase (HDAC) inhibitors." | 1.35 | Neuroendocrine transdifferentiation induced by VPA is mediated by PPARgamma activation and confers resistance to antiblastic therapy in prostate carcinoma. ( Angelucci, A; Bologna, M; Cerù, MP; Cimini, A; Cristiano, L; Dolo, V; Miano, R; Millimaggi, D; Muzi, P; Vicentini, C, 2008) |
| "A particular VPA/ATRA responsiveness of Philadelphia chromosome-positive (Ph+) acute lymphatic leukemia (ALL) was confirmed in a therapy-refractory patient in vivo." | 1.33 | FLT3-ITD-, but not BCR/ABL-transformed cells require concurrent Akt/mTor blockage to undergo apoptosis after histone deacetylase inhibitor treatment. ( Barth, PJ; Burchert, A; Cai, D; Neubauer, A; Ottmann, OG; Wang, Y, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 7 (63.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Andrade, FO | 1 |
| Nguyen, NM | 1 |
| Warri, A | 1 |
| Hilakivi-Clarke, L | 1 |
| Santoro, F | 1 |
| Botrugno, OA | 1 |
| Dal Zuffo, R | 2 |
| Pallavicini, I | 2 |
| Matthews, GM | 1 |
| Cluse, L | 1 |
| Barozzi, I | 1 |
| Senese, S | 1 |
| Fornasari, L | 1 |
| Moretti, S | 2 |
| Altucci, L | 1 |
| Pelicci, PG | 1 |
| Chiocca, S | 1 |
| Johnstone, RW | 1 |
| Minucci, S | 2 |
| Riva, G | 1 |
| Butta, V | 1 |
| Cilibrasi, C | 1 |
| Baronchelli, S | 1 |
| Redaelli, S | 1 |
| Dalprà, L | 1 |
| Lavitrano, M | 1 |
| Bentivegna, A | 1 |
| Aebischer, B | 1 |
| Elsig, S | 1 |
| Taeymans, J | 1 |
| Pomp, S | 1 |
| Kuhness, D | 1 |
| Barcaro, G | 1 |
| Sementa, L | 1 |
| Mankad, V | 1 |
| Fortunelli, A | 1 |
| Sterrer, M | 1 |
| Netzer, FP | 1 |
| Surnev, S | 1 |
| Schmieder, AH | 1 |
| Caruthers, SD | 1 |
| Keupp, J | 1 |
| Wickline, SA | 1 |
| Lanza, GM | 1 |
| Lowe, J | 1 |
| Wodarcyk, AJ | 1 |
| Floyd, KT | 1 |
| Rastogi, N | 1 |
| Schultz, EJ | 1 |
| Swager, SA | 1 |
| Chadwick, JA | 1 |
| Tran, T | 1 |
| Raman, SV | 1 |
| Janssen, PM | 1 |
| Rafael-Fortney, JA | 1 |
| Alcalay, RN | 1 |
| Levy, OA | 1 |
| Wolf, P | 1 |
| Oliva, P | 1 |
| Zhang, XK | 1 |
| Waters, CH | 1 |
| Fahn, S | 1 |
| Kang, U | 1 |
| Liong, C | 1 |
| Ford, B | 1 |
| Mazzoni, P | 1 |
| Kuo, S | 1 |
| Johnson, A | 1 |
| Xiong, L | 1 |
| Rouleau, GA | 1 |
| Chung, W | 1 |
| Marder, KS | 1 |
| Gan-Or, Z | 1 |
| Kamei, K | 1 |
| Terao, T | 1 |
| Katayama, Y | 1 |
| Hatano, K | 1 |
| Kodama, K | 1 |
| Shirahama, M | 1 |
| Sakai, A | 1 |
| Hirakawa, H | 1 |
| Mizokami, Y | 1 |
| Shiotsuki, I | 1 |
| Ishii, N | 1 |
| Inoue, Y | 1 |
| Akboga, MK | 1 |
| Yayla, C | 1 |
| Balci, KG | 1 |
| Ozeke, O | 1 |
| Maden, O | 1 |
| Kisacik, H | 1 |
| Temizhan, A | 1 |
| Aydogdu, S | 1 |
| Zhu, J | 2 |
| Ying, SH | 1 |
| Feng, MG | 1 |
| Zhang, XG | 1 |
| Li, H | 1 |
| Wang, L | 2 |
| Hao, YY | 1 |
| Liang, GD | 1 |
| Ma, YH | 1 |
| Yang, GS | 1 |
| Hu, JH | 1 |
| Pfeifer, L | 1 |
| Goertz, RS | 1 |
| Neurath, MF | 1 |
| Strobel, D | 1 |
| Wildner, D | 1 |
| Lin, JT | 1 |
| Yang, XN | 1 |
| Zhong, WZ | 1 |
| Liao, RQ | 1 |
| Dong, S | 1 |
| Nie, Q | 1 |
| Weng, SX | 1 |
| Fang, XJ | 1 |
| Zheng, JY | 1 |
| Wu, YL | 1 |
| Řezanka, T | 1 |
| Kaineder, K | 1 |
| Mezricky, D | 1 |
| Řezanka, M | 1 |
| Bišová, K | 1 |
| Zachleder, V | 1 |
| Vítová, M | 1 |
| Rinker, JA | 1 |
| Marshall, SA | 1 |
| Mazzone, CM | 1 |
| Lowery-Gionta, EG | 1 |
| Gulati, V | 1 |
| Pleil, KE | 1 |
| Kash, TL | 1 |
| Navarro, M | 1 |
| Thiele, TE | 1 |
| Zhang, Y | 1 |
| Huang, Y | 1 |
| Jin, Z | 1 |
| Li, X | 1 |
| Li, B | 1 |
| Xu, P | 1 |
| Huang, P | 1 |
| Liu, C | 1 |
| Fokdal, L | 1 |
| Sturdza, A | 1 |
| Mazeron, R | 1 |
| Haie-Meder, C | 1 |
| Tan, LT | 1 |
| Gillham, C | 1 |
| Šegedin, B | 1 |
| Jürgenliemk-Schultz, I | 1 |
| Kirisits, C | 1 |
| Hoskin, P | 1 |
| Pötter, R | 1 |
| Lindegaard, JC | 1 |
| Tanderup, K | 1 |
| Levin, DE | 1 |
| Schmitz, AJ | 1 |
| Hines, SM | 1 |
| Hines, KJ | 1 |
| Tucker, MJ | 1 |
| Brewer, SH | 1 |
| Fenlon, EE | 1 |
| Álvarez-Pérez, S | 1 |
| Blanco, JL | 1 |
| Peláez, T | 1 |
| Martínez-Nevado, E | 1 |
| García, ME | 1 |
| Puckerin, AA | 1 |
| Chang, DD | 1 |
| Subramanyam, P | 1 |
| Colecraft, HM | 1 |
| Dogan, H | 1 |
| Coteli, E | 1 |
| Karatas, F | 1 |
| Ceylan, O | 1 |
| Sahin, MD | 1 |
| Akdamar, G | 1 |
| Kryczyk, A | 1 |
| Żmudzki, P | 1 |
| Hubicka, U | 1 |
| Giovannelli, D | 1 |
| Chung, M | 1 |
| Staley, J | 1 |
| Starovoytov, V | 1 |
| Le Bris, N | 1 |
| Vetriani, C | 1 |
| Chen, W | 1 |
| Wu, L | 1 |
| Liu, X | 1 |
| Shen, Y | 1 |
| Liang, Y | 1 |
| Tan, H | 1 |
| Yang, Y | 1 |
| Liu, Q | 1 |
| Wang, M | 1 |
| Liu, L | 1 |
| Wang, X | 1 |
| Liu, B | 1 |
| Liu, GH | 1 |
| Zhu, YJ | 1 |
| Wang, JP | 1 |
| Che, JM | 1 |
| Chen, QQ | 1 |
| Chen, Z | 1 |
| Maucksch, U | 1 |
| Runge, R | 1 |
| Wunderlich, G | 1 |
| Freudenberg, R | 1 |
| Naumann, A | 1 |
| Kotzerke, J | 1 |
| Xu, XS | 1 |
| Abrams, J | 1 |
| Wang, G | 1 |
| Venkataramani, V | 1 |
| Thiele, K | 1 |
| Behnes, CL | 1 |
| Wulf, GG | 1 |
| Thelen, P | 1 |
| Opitz, L | 1 |
| Salinas-Riester, G | 1 |
| Wirths, O | 1 |
| Bayer, TA | 1 |
| Schweyer, S | 1 |
| Leiva, M | 1 |
| Soilihi, H | 1 |
| Peres, L | 1 |
| Mercurio, C | 1 |
| de Thé, H | 1 |
| McGarry, LC | 1 |
| Winnie, JN | 1 |
| Ozanne, BW | 1 |
| Zhu, P | 1 |
| Martin, E | 1 |
| Mengwasser, J | 1 |
| Schlag, P | 1 |
| Janssen, KP | 1 |
| Göttlicher, M | 1 |
| Cai, D | 1 |
| Wang, Y | 1 |
| Ottmann, OG | 1 |
| Barth, PJ | 1 |
| Neubauer, A | 1 |
| Burchert, A | 1 |
| Angelucci, A | 1 |
| Muzi, P | 1 |
| Cristiano, L | 1 |
| Millimaggi, D | 1 |
| Cimini, A | 1 |
| Dolo, V | 1 |
| Miano, R | 1 |
| Vicentini, C | 1 |
| Cerù, MP | 1 |
| Bologna, M | 1 |
1 review available for valproic acid and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Topics: AC133 Antigen; Acenaphthenes; Acer; Acrosome Reaction; Adult; Agaricales; Aged; Aged, 80 and over; A | 2016 |
10 other studies available for valproic acid and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Reversal of increased mammary tumorigenesis by valproic acid and hydralazine in offspring of dams fed high fat diet during pregnancy.
Topics: Animals; Cell Transformation, Neoplastic; CpG Islands; Cyclin-Dependent Kinase Inhibitor p16; Diet, | 2019 |
A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance.
Topics: Animals; Blotting, Western; Cell Differentiation; Cell Proliferation; Cell Transformation, Neoplasti | 2013 |
Epigenetic targeting of glioma stem cells: Short-term and long-term treatments with valproic acid modulate DNA methylation and differentiation behavior, but not temozolomide sensitivity.
Topics: Antineoplastic Agents, Alkylating; Cell Line, Tumor; Cell Shape; Cell Survival; Cell Transformation, | 2016 |
Histone deacetylases (HDACs) in XPC gene silencing and bladder cancer.
Topics: Caspase 3; Cell Line, Tumor; Cell Transformation, Neoplastic; Chromatin Immunoprecipitation; Cisplat | 2011 |
Amyloid precursor protein is a biomarker for transformed human pluripotent stem cells.
Topics: Adolescent; Adult; Amyloid beta-Protein Precursor; Animals; Biomarkers, Tumor; Cell Differentiation; | 2012 |
Valproic acid induces differentiation and transient tumor regression, but spares leukemia-initiating activity in mouse models of APL.
Topics: Acetylation; Animals; Anticonvulsants; Antineoplastic Agents; Cell Differentiation; Cell Transformat | 2012 |
Invasion of v-Fos(FBR)-transformed cells is dependent upon histone deacetylase activity and suppression of histone deacetylase regulated genes.
Topics: Actins; Animals; Blotting, Northern; Blotting, Western; Cadherin Related Proteins; Cadherins; Cell D | 2004 |
Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis.
Topics: Adenoma; Adenomatous Polyposis Coli Protein; Animals; Apoptosis; beta Catenin; Cell Cycle; Cell Tran | 2004 |
FLT3-ITD-, but not BCR/ABL-transformed cells require concurrent Akt/mTor blockage to undergo apoptosis after histone deacetylase inhibitor treatment.
Topics: Antineoplastic Agents; Apoptosis; Caspases; Cell Transformation, Neoplastic; Drug Resistance, Neopla | 2006 |
Neuroendocrine transdifferentiation induced by VPA is mediated by PPARgamma activation and confers resistance to antiblastic therapy in prostate carcinoma.
Topics: Adenocarcinoma; Anilides; Animals; Cell Line, Tumor; Cell Proliferation; Cell Transdifferentiation; | 2008 |