valproic acid has been researched along with Carditis in 8 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clozapine is the most effective medication for treatment-refractory schizophrenia, but it is associated with severe cardiac adverse events including myocarditis and cardiomyopathy." | 9.22 | Risk factors for clozapine-induced myocarditis and cardiomyopathy: A systematic review and meta-analysis. ( Eriksson, L; Malacova, E; McMahon, K; Moudgil, V; Ramineni, V; Scott, J; Siskind, D; Vickers, M, 2022) |
| "Objectives: Clozapine-induced myocarditis may be a hypersensitivity reaction due to titration that was too rapid for a patient's clozapine metabolism." | 8.12 | Four cases of myocarditis in US hospitals possibly associated with clozapine poor metabolism and a comparison with prior published cases. ( Coleman, JK; Cotes, RO; De Leon, J; Goldsmith, DR; Koenig, M; McCollum, B; Shelton, C; Spivey, JK, 2022) |
| "Clozapine, atypical antipsychotic drug, is widely used in patients with schizophrenia, for whom previous therapy was inadequate or not tolerated." | 7.91 | Clozapine-induced myocarditis during co-administration of valproate: A case report. ( Jahołkowski, P; Kowalski, M; Niewiadomska, J; Świtaj, P; Wciórka, J, 2019) |
| "The aim of this study was to investigate and compare the incidence of suspected or definite cases of clozapine induced myocarditis (SDM) and clinical factors which could influence its onset in two different time periods, defined by pre- and post-cardiac monitoring at an inpatient setting, during the initiation phase of clozapine treatment." | 7.91 | A comparative study of detection of myocarditis induced by clozapine: With and without cardiac monitoring. ( Ağaoğlu, E; Ak, S; Anıl Yağcıoğlu, AE; Ertuğrul, A; Karahan, S; Karakaşlı, AA; Yazıcı, MK, 2019) |
| "Despite the implementation of cardiac monitoring guidelines, clozapine-induced myocarditis continues to cause deaths in Australia, and the risk is a barrier to prescription of this effective drug for the treatment of schizophrenia." | 7.78 | Rapid clozapine dose titration and concomitant sodium valproate increase the risk of myocarditis with clozapine: a case-control study. ( Fitzgerald, PB; McNeil, JJ; Ronaldson, KJ; Taylor, AJ; Topliss, DJ; Wolfe, R, 2012) |
| "He had been on a lamotrigine treatment due to epilepsy, and after cessation of lamotrigine, his cardiac enzyme levels returned to normal." | 5.38 | Lamotrigine related myocarditis: case report. ( Bayhan, T; Karagöz, T; Sahin, M; Yıldırım, I, 2012) |
| "Clozapine is the most effective medication for treatment-refractory schizophrenia, but it is associated with severe cardiac adverse events including myocarditis and cardiomyopathy." | 5.22 | Risk factors for clozapine-induced myocarditis and cardiomyopathy: A systematic review and meta-analysis. ( Eriksson, L; Malacova, E; McMahon, K; Moudgil, V; Ramineni, V; Scott, J; Siskind, D; Vickers, M, 2022) |
| "Objectives: Clozapine-induced myocarditis may be a hypersensitivity reaction due to titration that was too rapid for a patient's clozapine metabolism." | 4.12 | Four cases of myocarditis in US hospitals possibly associated with clozapine poor metabolism and a comparison with prior published cases. ( Coleman, JK; Cotes, RO; De Leon, J; Goldsmith, DR; Koenig, M; McCollum, B; Shelton, C; Spivey, JK, 2022) |
| "Clozapine (CLZ) is a gold-standard antipsychotic against treatment-refractory schizophrenia, but is one of the most toxic antipsychotic agents." | 3.96 | Activation of Astroglial Connexin is Involved in Concentration-Dependent Double-Edged Sword Clinical Action of Clozapine. ( Fukuyama, K; Murata, M; Okada, M; Okubo, R; Shiroyama, T, 2020) |
| "Clozapine, atypical antipsychotic drug, is widely used in patients with schizophrenia, for whom previous therapy was inadequate or not tolerated." | 3.91 | Clozapine-induced myocarditis during co-administration of valproate: A case report. ( Jahołkowski, P; Kowalski, M; Niewiadomska, J; Świtaj, P; Wciórka, J, 2019) |
| "The aim of this study was to investigate and compare the incidence of suspected or definite cases of clozapine induced myocarditis (SDM) and clinical factors which could influence its onset in two different time periods, defined by pre- and post-cardiac monitoring at an inpatient setting, during the initiation phase of clozapine treatment." | 3.91 | A comparative study of detection of myocarditis induced by clozapine: With and without cardiac monitoring. ( Ağaoğlu, E; Ak, S; Anıl Yağcıoğlu, AE; Ertuğrul, A; Karahan, S; Karakaşlı, AA; Yazıcı, MK, 2019) |
| "Despite the implementation of cardiac monitoring guidelines, clozapine-induced myocarditis continues to cause deaths in Australia, and the risk is a barrier to prescription of this effective drug for the treatment of schizophrenia." | 3.78 | Rapid clozapine dose titration and concomitant sodium valproate increase the risk of myocarditis with clozapine: a case-control study. ( Fitzgerald, PB; McNeil, JJ; Ronaldson, KJ; Taylor, AJ; Topliss, DJ; Wolfe, R, 2012) |
| "He had been on a lamotrigine treatment due to epilepsy, and after cessation of lamotrigine, his cardiac enzyme levels returned to normal." | 1.38 | Lamotrigine related myocarditis: case report. ( Bayhan, T; Karagöz, T; Sahin, M; Yıldırım, I, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 3 (37.50) | 2.80 |
| Authors | Studies |
|---|---|
| Vickers, M | 1 |
| Ramineni, V | 1 |
| Malacova, E | 1 |
| Eriksson, L | 1 |
| McMahon, K | 1 |
| Moudgil, V | 1 |
| Scott, J | 1 |
| Siskind, D | 1 |
| Koenig, M | 1 |
| McCollum, B | 1 |
| Spivey, JK | 1 |
| Coleman, JK | 1 |
| Shelton, C | 1 |
| Cotes, RO | 1 |
| Goldsmith, DR | 1 |
| De Leon, J | 1 |
| Jahołkowski, P | 1 |
| Niewiadomska, J | 1 |
| Wciórka, J | 1 |
| Kowalski, M | 1 |
| Świtaj, P | 1 |
| Fukuyama, K | 1 |
| Okubo, R | 1 |
| Murata, M | 1 |
| Shiroyama, T | 1 |
| Okada, M | 1 |
| Anıl Yağcıoğlu, AE | 1 |
| Ertuğrul, A | 1 |
| Karakaşlı, AA | 1 |
| Ağaoğlu, E | 1 |
| Ak, S | 1 |
| Karahan, S | 1 |
| Yazıcı, MK | 1 |
| Jin, H | 1 |
| Guo, X | 1 |
| Bayhan, T | 1 |
| Sahin, M | 1 |
| Yıldırım, I | 1 |
| Karagöz, T | 1 |
| Ronaldson, KJ | 1 |
| Fitzgerald, PB | 1 |
| Taylor, AJ | 1 |
| Topliss, DJ | 1 |
| Wolfe, R | 1 |
| McNeil, JJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Switching Antipsychotics: Abrupt Discontinuation Versus Overlap[NCT02640300] | Phase 4 | 33 participants (Actual) | Interventional | 1999-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for valproic acid and Carditis
| Article | Year |
|---|---|
Risk factors for clozapine-induced myocarditis and cardiomyopathy: A systematic review and meta-analysis.
Topics: Antipsychotic Agents; Cardiomyopathies; Clozapine; Humans; Myocarditis; Risk Factors; Valproic Acid | 2022 |
7 other studies available for valproic acid and Carditis
| Article | Year |
|---|---|
Four cases of myocarditis in US hospitals possibly associated with clozapine poor metabolism and a comparison with prior published cases.
Topics: Antipsychotic Agents; Clozapine; Hospitals; Humans; Male; Myocarditis; Obesity; Schizophrenia; Valpr | 2022 |
Clozapine-induced myocarditis during co-administration of valproate: A case report.
Topics: Antipsychotic Agents; Clozapine; Drug Therapy, Combination; Humans; Male; Myocarditis; Schizophrenia | 2019 |
Activation of Astroglial Connexin is Involved in Concentration-Dependent Double-Edged Sword Clinical Action of Clozapine.
Topics: Antipsychotic Agents; Astrocytes; Cell Membrane; Clozapine; Connexin 43; Glutamic Acid; Humans; Myoc | 2020 |
A comparative study of detection of myocarditis induced by clozapine: With and without cardiac monitoring.
Topics: Adult; Antipsychotic Agents; Clozapine; Drug Therapy, Combination; Female; Humans; Incidence; Inpati | 2019 |
Valproic acid ameliorates coxsackievirus-B3-induced viral myocarditis by modulating Th17/Treg imbalance.
Topics: Animals; Body Weight; Coxsackievirus Infections; Cytokines; Disease Models, Animal; Enterovirus B, H | 2016 |
Lamotrigine related myocarditis: case report.
Topics: Adolescent; Anticonvulsants; Electrocardiography; Epilepsy; Humans; Lamotrigine; Magnetic Resonance | 2012 |
Rapid clozapine dose titration and concomitant sodium valproate increase the risk of myocarditis with clozapine: a case-control study.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Antipsychotic Agents; Area Under Curve; Body | 2012 |