valproic acid has been researched along with Cardiovascular Stroke in 9 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we aim to determine whether Valproic acid (VPA), a FDA approved inhibitor of histone deacetylation for bipolar disease, could protect heart against myocardial infarction (MI) injury and elucidate key molecular pathways." | 7.91 | HDAC inhibitor valproic acid protects heart function through Foxm1 pathway after acute myocardial infarction. ( Alam, HB; Creech, J; Eugene Chen, Y; Gao, W; Guo, Y; Herron, TJ; Lei, I; Li, Y; Liu, L; Ma, PX; Tian, S; Wang, Z; Xian, S, 2019) |
| " Here, we aim to determine whether Valproic acid (VPA), a FDA approved inhibitor of histone deacetylation for bipolar disease, could protect heart against myocardial infarction (MI) injury and elucidate key molecular pathways." | 3.91 | HDAC inhibitor valproic acid protects heart function through Foxm1 pathway after acute myocardial infarction. ( Alam, HB; Creech, J; Eugene Chen, Y; Gao, W; Guo, Y; Herron, TJ; Lei, I; Li, Y; Liu, L; Ma, PX; Tian, S; Wang, Z; Xian, S, 2019) |
| "Two cohorts of patients with valproate-treated epilepsy and sex- and age-matched individuals (controls) from the general Danish population were identified by individual-level-linkage of nationwide registries and followed for 10 years." | 1.37 | Valproate attenuates the risk of myocardial infarction in patients with epilepsy: a nationwide cohort study. ( Abildstrøm, SZ; Andersson, C; Erdal, J; Gislason, GH; Hansen, PR; Olesen, JB; Schmiegelow, M; Torp-Pedersen, C; Weeke, P, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Guo, S | 1 |
| Zhang, Y | 2 |
| Meng, F | 1 |
| Li, M | 1 |
| Yu, Z | 1 |
| Chen, Y | 1 |
| Cui, G | 1 |
| Tian, S | 1 |
| Lei, I | 1 |
| Gao, W | 1 |
| Liu, L | 1 |
| Guo, Y | 1 |
| Creech, J | 1 |
| Herron, TJ | 1 |
| Xian, S | 1 |
| Ma, PX | 1 |
| Eugene Chen, Y | 1 |
| Li, Y | 1 |
| Alam, HB | 1 |
| Wang, Z | 1 |
| Dregan, A | 1 |
| Charlton, J | 1 |
| Wolfe, CD | 1 |
| Gulliford, MC | 1 |
| Markus, HS | 1 |
| Svennerholm, K | 1 |
| Haney, M | 1 |
| Biber, B | 1 |
| Ulfhammer, E | 1 |
| Saluveer, O | 1 |
| Larsson, P | 1 |
| Omerovic, E | 1 |
| Jern, S | 1 |
| Bergh, N | 1 |
| Ladds, B | 1 |
| Thomas, P | 1 |
| Mejia, C | 1 |
| Hauser, D | 1 |
| Olesen, JB | 1 |
| Hansen, PR | 1 |
| Abildstrøm, SZ | 1 |
| Andersson, C | 1 |
| Weeke, P | 1 |
| Schmiegelow, M | 1 |
| Erdal, J | 1 |
| Torp-Pedersen, C | 1 |
| Gislason, GH | 1 |
| Lee, TM | 1 |
| Lin, MS | 1 |
| Chang, NC | 1 |
| Abdikaliev, NA | 1 |
| Shabunina, EV | 1 |
| Meerson, FZ | 1 |
| Fahn, S | 1 |
1 review available for valproic acid and Cardiovascular Stroke
| Article | Year |
|---|---|
Posthypoxic action myoclonus: literature review update.
Topics: Adult; Clonazepam; Coma; Electroencephalography; Female; Functional Laterality; Heart Arrest; Humans | 1986 |
8 other studies available for valproic acid and Cardiovascular Stroke
| Article | Year |
|---|---|
Multiple Intravenous Injections of Valproic Acid-Induced Mesenchymal Stem Cell from Human-Induced Pluripotent Stem Cells Improved Cardiac Function in an Acute Myocardial Infarction Rat Model.
Topics: Animals; Cell Differentiation; Disease Models, Animal; Humans; Induced Pluripotent Stem Cells; Injec | 2020 |
HDAC inhibitor valproic acid protects heart function through Foxm1 pathway after acute myocardial infarction.
Topics: Animals; Cell Hypoxia; Disease Models, Animal; Forkhead Box Protein M1; Gene Expression Regulation; | 2019 |
Is sodium valproate, an HDAC inhibitor, associated with reduced risk of stroke and myocardial infarction? A nested case-control study.
Topics: Aged; Aged, 80 and over; Bias; Brain Ischemia; Case-Control Studies; Databases, Factual; Electronic | 2014 |
Histone deacetylase inhibition enhances tissue plasminogen activator release capacity in atherosclerotic man.
Topics: Aged; Female; Forearm; Histone Deacetylase Inhibitors; Humans; Isoproterenol; Male; Middle Aged; Myo | 2015 |
Extreme elevation of creatinine phosphokinase levels in neuroleptic malignant syndrome associated with atypical antipsychotics.
Topics: Adult; Antipsychotic Agents; Aripiprazole; Clozapine; Creatine Kinase; Dose-Response Relationship, D | 2009 |
Valproate attenuates the risk of myocardial infarction in patients with epilepsy: a nationwide cohort study.
Topics: Adult; Aged; Anticonvulsants; Case-Control Studies; Cause of Death; Chi-Square Distribution; Cohort | 2011 |
Inhibition of histone deacetylase on ventricular remodeling in infarcted rats.
Topics: Animals; Atrial Natriuretic Factor; Blotting, Western; Cardiomegaly; Cell Size; Collagen; Coronary V | 2007 |
[Elimination of disorders in the electrical stability of the heart during postinfarct cardiosclerosis by using a factor that induces GABA accumulation in the brain].
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Brain; Drug Evaluation, Preclinical; Electroc | 1989 |