valproic acid has been researched along with Cardiac Remodeling, Ventricular in 6 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Renovascular hypertension was induced in rats by the two-kidney two-clip (2K2C) method." | 1.46 | Roles of HDAC2 and HDAC8 in Cardiac Remodeling in Renovascular Hypertensive Rats and the Effects of Valproic Acid Sodium. ( Cao, SS; Fang, WJ; Li, RF; Luo, XT; Song, Y; Wang, HY; Wang, JG, 2017) |
| "The regulatory paradigm in cardiac hypertrophy involves alterations in gene expression that is mediated by chromatin remodeling." | 1.46 | Selective inhibition of HDAC2 by magnesium valproate attenuates cardiac hypertrophy. ( Goyal, RK; Patel, BM; Raghunathan, S, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jung, H | 1 |
| Lee, E | 1 |
| Kim, I | 1 |
| Song, JH | 1 |
| Kim, GJ | 1 |
| Mamalyga, ML | 1 |
| Li, RF | 1 |
| Cao, SS | 1 |
| Fang, WJ | 1 |
| Song, Y | 1 |
| Luo, XT | 1 |
| Wang, HY | 1 |
| Wang, JG | 1 |
| Raghunathan, S | 1 |
| Goyal, RK | 1 |
| Patel, BM | 1 |
| Bogaard, HJ | 1 |
| Mizuno, S | 1 |
| Hussaini, AA | 1 |
| Toldo, S | 1 |
| Abbate, A | 1 |
| Kraskauskas, D | 1 |
| Kasper, M | 1 |
| Natarajan, R | 1 |
| Voelkel, NF | 1 |
| Lee, TM | 1 |
| Lin, MS | 1 |
| Chang, NC | 1 |
6 other studies available for valproic acid and Cardiac Remodeling, Ventricular
| Article | Year |
|---|---|
Histone deacetylase inhibition has cardiac and vascular protective effects in rats with pressure overload cardiac hypertrophy.
Topics: Animals; Aorta; Arterial Pressure; Disease Models, Animal; Fibrosis; Gene Expression Regulation; His | 2019 |
[Functional state of cardiovascular system by progressive absences--epilepsy and its treatment].
Topics: Animals; Anticonvulsants; Arrhythmias, Cardiac; Brain; Electrocardiography; Epilepsy, Absence; Heart | 2014 |
Roles of HDAC2 and HDAC8 in Cardiac Remodeling in Renovascular Hypertensive Rats and the Effects of Valproic Acid Sodium.
Topics: Animals; Enzyme Inhibitors; Histone Deacetylase 2; Histone Deacetylases; Hypertension, Renovascular; | 2017 |
Selective inhibition of HDAC2 by magnesium valproate attenuates cardiac hypertrophy.
Topics: Animals; Biomarkers; Cardiomegaly; Disease Models, Animal; DNA, Mitochondrial; Down-Regulation; Fema | 2017 |
Suppression of histone deacetylases worsens right ventricular dysfunction after pulmonary artery banding in rats.
Topics: Angiopoietin-1; Animals; Blotting, Western; Cells, Cultured; Disease Models, Animal; Dose-Response R | 2011 |
Inhibition of histone deacetylase on ventricular remodeling in infarcted rats.
Topics: Animals; Atrial Natriuretic Factor; Blotting, Western; Cardiomegaly; Cell Size; Collagen; Coronary V | 2007 |