valproic acid has been researched along with Carcinogenesis in 3 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Carcinogenesis: The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we investigated the mechanism of how valproic acid (VPA) interferes with the carcinogenesis of PAHs protect normal tissues via the regulation of macrophages' function." | 4.12 | Valproic acid counteracts polycyclic aromatic hydrocarbons (PAHs)-induced tumorigenic effects by regulating the polarization of macrophages. ( Cai, Z; Chu, G; Dong, C; Feng, Z; Jia, B; Lim, D; Peng, J; Zhang, F; Zhang, Y, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, Y | 1 |
| Lim, D | 1 |
| Cai, Z | 1 |
| Peng, J | 1 |
| Jia, B | 1 |
| Chu, G | 1 |
| Zhang, F | 1 |
| Dong, C | 1 |
| Feng, Z | 1 |
| Chanda, S | 1 |
| Ang, CE | 1 |
| Lee, QY | 1 |
| Ghebrial, M | 1 |
| Haag, D | 1 |
| Shibuya, Y | 1 |
| Wernig, M | 1 |
| Südhof, TC | 1 |
| Stypula-Cyrus, Y | 1 |
| Damania, D | 1 |
| Kunte, DP | 1 |
| Cruz, MD | 1 |
| Subramanian, H | 1 |
| Roy, HK | 1 |
| Backman, V | 1 |
3 other studies available for valproic acid and Carcinogenesis
| Article | Year |
|---|---|
Valproic acid counteracts polycyclic aromatic hydrocarbons (PAHs)-induced tumorigenic effects by regulating the polarization of macrophages.
Topics: Carcinogenesis; Carcinogens; CD8-Positive T-Lymphocytes; Cytokines; Endothelial Cells; Humans; Macro | 2022 |
Direct Reprogramming of Human Neurons Identifies MARCKSL1 as a Pathogenic Mediator of Valproic Acid-Induced Teratogenicity.
Topics: Animals; Calmodulin-Binding Proteins; Carcinogenesis; Cells, Cultured; Cellular Reprogramming; Elect | 2019 |
HDAC up-regulation in early colon field carcinogenesis is involved in cell tumorigenicity through regulation of chromatin structure.
Topics: Animals; Carcinogenesis; Cell Survival; Chromatin; Colorectal Neoplasms; Histone Deacetylase Inhibit | 2013 |