valproic acid has been researched along with Canine Diseases in 4 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Blood and tumor tissue were collected for determination of serum valproic acid concentration and evaluation of pharmacodynamic effects by immunofluorescence cytochemistry and immunohistochemistry." | 2.75 | Phase I pharmacokinetic and pharmacodynamic evaluation of combined valproic acid/doxorubicin treatment in dogs with spontaneous cancer. ( Gustafson, DL; Thamm, DH; Wittenburg, LA, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Suzuki, T | 1 |
| Aoshima, K | 1 |
| Yamazaki, J | 1 |
| Kobayashi, A | 1 |
| Kimura, T | 1 |
| Song, R | 1 |
| Yu, D | 1 |
| Yoon, J | 1 |
| Park, J | 1 |
| Wittenburg, LA | 1 |
| Gustafson, DL | 1 |
| Thamm, DH | 1 |
| Frey, HH | 1 |
| Löscher, W | 1 |
1 review available for valproic acid and Canine Diseases
| Article | Year |
|---|---|
Pharmacokinetics of anti-epileptic drugs in the dog: a review.
Topics: Animals; Anticonvulsants; Blood Proteins; Carbamazepine; Clonazepam; Diazepam; Dog Diseases; Dogs; E | 1985 |
1 trial available for valproic acid and Canine Diseases
| Article | Year |
|---|---|
Phase I pharmacokinetic and pharmacodynamic evaluation of combined valproic acid/doxorubicin treatment in dogs with spontaneous cancer.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chromatography, Liqu | 2010 |
2 other studies available for valproic acid and Canine Diseases
| Article | Year |
|---|---|
Manipulating histone acetylation leads to antitumor effects in hemangiosarcoma cells.
Topics: Acetylation; Animals; Apoptosis; Cell Line, Tumor; Dog Diseases; Dogs; Endothelial Cells; Hemangiosa | 2022 |
Valproic acid attenuates the expression of pro-inflammatory cytokines lipopolysaccharide-treated canine peripheral blood mononuclear cells (in vitro) and in a canine endotoxemia model (in vivo).
Topics: Animals; Anti-Inflammatory Agents; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Endotoxemia | 2015 |