valproic acid has been researched along with Cancer of Head in 9 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN) has a poor prognosis and the combination of cisplatin and cetuximab, with or without 5-fluorouracil, is the gold standard treatment in this stage." | 6.82 | Phase II clinical study of valproic acid plus cisplatin and cetuximab in recurrent and/or metastatic squamous cell carcinoma of Head and Neck-V-CHANCE trial. ( Aversa, C; Botti, G; Bruzzese, F; Budillon, A; Calogero, E; Caponigro, F; Cavalcanti, E; D'Aniello, R; Daponte, A; De Cecio, R; De Feo, G; Di Gennaro, E; Di Marzo, M; Ionna, F; Longo, F; Losito, NS; Maglione, MG; Maiolino, P; Montano, M; Muto, P; Pavone, E; Perri, F; Petrillo, A; Pontone, M; Sandomenico, F; Scala, S; Trotta, A; Zotti, AI, 2016) |
| "Recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN) has a poor prognosis and the combination of cisplatin and cetuximab, with or without 5-fluorouracil, is the gold standard treatment in this stage." | 2.82 | Phase II clinical study of valproic acid plus cisplatin and cetuximab in recurrent and/or metastatic squamous cell carcinoma of Head and Neck-V-CHANCE trial. ( Aversa, C; Botti, G; Bruzzese, F; Budillon, A; Calogero, E; Caponigro, F; Cavalcanti, E; D'Aniello, R; Daponte, A; De Cecio, R; De Feo, G; Di Gennaro, E; Di Marzo, M; Ionna, F; Longo, F; Losito, NS; Maglione, MG; Maiolino, P; Montano, M; Muto, P; Pavone, E; Perri, F; Petrillo, A; Pontone, M; Sandomenico, F; Scala, S; Trotta, A; Zotti, AI, 2016) |
| "Valproic acid is an antiepileptic drug with more than 50 years of clinical use." | 2.61 | El ácido valproico como agente sensibilizador al tratamiento anticáncer. ( Correa-Basurto, J; Luna-Palencia, GR; Vásquez-Moctezuma, I, 2019) |
| "Growth inhibition profiles of HNSCC cell lines varied in response to VPA." | 1.38 | Valproic acid: growth inhibition of head and neck cancer by induction of terminal differentiation and senescence. ( Cheong, SC; Gan, CP; Hamid, S; Hor, SY; Ismail, SM; Saunders, N; Teo, SH; Wan Mustafa, WM; Zain, RB, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 7 (77.78) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Luna-Palencia, GR | 1 |
| Correa-Basurto, J | 1 |
| Vásquez-Moctezuma, I | 1 |
| Gama, RR | 1 |
| Arantes, LMRB | 1 |
| Sorroche, BP | 1 |
| De Marchi, P | 1 |
| Melendez, ME | 1 |
| Carvalho, RS | 1 |
| de Lima, MA | 1 |
| Vettore, AL | 1 |
| Carvalho, AL | 1 |
| Lee, BS | 1 |
| Kim, YS | 2 |
| Kim, HJ | 1 |
| Kim, DH | 1 |
| Won, HR | 1 |
| Kim, CH | 1 |
| Kang, H | 1 |
| Gillespie, TW | 1 |
| Goodman, M | 1 |
| Brodie, SA | 1 |
| Brandes, M | 1 |
| Ribeiro, M | 1 |
| Ramalingam, SS | 1 |
| Shin, DM | 1 |
| Khuri, FR | 1 |
| Brandes, JC | 1 |
| Lee, SH | 1 |
| Nam, HJ | 1 |
| Kang, HJ | 1 |
| Samuels, TL | 1 |
| Johnston, N | 1 |
| Lim, YC | 1 |
| Caponigro, F | 1 |
| Di Gennaro, E | 1 |
| Ionna, F | 1 |
| Longo, F | 1 |
| Aversa, C | 1 |
| Pavone, E | 1 |
| Maglione, MG | 1 |
| Di Marzo, M | 1 |
| Muto, P | 1 |
| Cavalcanti, E | 1 |
| Petrillo, A | 1 |
| Sandomenico, F | 1 |
| Maiolino, P | 1 |
| D'Aniello, R | 1 |
| Botti, G | 1 |
| De Cecio, R | 1 |
| Losito, NS | 1 |
| Scala, S | 1 |
| Trotta, A | 1 |
| Zotti, AI | 1 |
| Bruzzese, F | 1 |
| Daponte, A | 1 |
| Calogero, E | 1 |
| Montano, M | 1 |
| Pontone, M | 1 |
| De Feo, G | 1 |
| Perri, F | 1 |
| Budillon, A | 1 |
| Kothari, V | 1 |
| Joshi, G | 1 |
| Nama, S | 1 |
| Somasundaram, K | 1 |
| Mulherkar, R | 1 |
| Gan, CP | 1 |
| Hamid, S | 1 |
| Hor, SY | 1 |
| Zain, RB | 1 |
| Ismail, SM | 1 |
| Wan Mustafa, WM | 1 |
| Teo, SH | 1 |
| Saunders, N | 1 |
| Cheong, SC | 1 |
| Erlich, RB | 1 |
| Rickwood, D | 1 |
| Coman, WB | 1 |
| Saunders, NA | 1 |
| Guminski, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 0 Clinical Trial With Valproic Acid as a Chemopreventive Agent in Patients With Head and Neck Squamous Cell Carcinoma Previously Treated[NCT02608736] | Early Phase 1 | 42 participants (Actual) | Interventional | 2015-12-31 | Completed | ||
| Preclinical and Clinical Study of Valproic Acid Plus Cisplatin and Cetuximab in Recurrent and/or Metastatic Squamous Cell Carcinoma of Head and Neck[NCT02624128] | Phase 2 | 39 participants (Anticipated) | Interventional | 2015-02-23 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for valproic acid and Cancer of Head
| Article | Year |
|---|---|
El ácido valproico como agente sensibilizador al tratamiento anticáncer.
Topics: Anticonvulsants; Antineoplastic Combined Chemotherapy Protocols; Head and Neck Neoplasms; Humans; Ne | 2019 |
2 trials available for valproic acid and Cancer of Head
| Article | Year |
|---|---|
Evaluation of acetylation and methylation in oral rinse of patients with head and neck cancer history exposed to valproic acid.
Topics: Acetylation; DNA Methylation; Double-Blind Method; Female; Head and Neck Neoplasms; Histones; Humans | 2021 |
Phase II clinical study of valproic acid plus cisplatin and cetuximab in recurrent and/or metastatic squamous cell carcinoma of Head and Neck-V-CHANCE trial.
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cetu | 2016 |
6 other studies available for valproic acid and Cancer of Head
| Article | Year |
|---|---|
HDAC4 degradation by combined TRAIL and valproic acid treatment induces apoptotic cell death of TRAIL-resistant head and neck cancer cells.
Topics: Caspases; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; Drug Syner | 2018 |
Long-term use of valproic acid in US veterans is associated with a reduced risk of smoking-related cases of head and neck cancer.
Topics: Carcinoma, Squamous Cell; Cohort Studies; Enzyme Inhibitors; Female; Head and Neck Neoplasms; Histon | 2014 |
Valproic acid suppresses the self-renewal and proliferation of head and neck cancer stem cells.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Ce | 2015 |
HDAC inhibitor valproic acid enhances tumor cell kill in adenovirus-HSVtk mediated suicide gene therapy in HNSCC xenograft mouse model.
Topics: Adenoviruses, Human; Animals; Bystander Effect; Carcinoma, Squamous Cell; Cell Line, Tumor; Combined | 2010 |
Valproic acid: growth inhibition of head and neck cancer by induction of terminal differentiation and senescence.
Topics: Antineoplastic Agents; Azacitidine; Carcinoma, Squamous Cell; Cell Culture Techniques; Cell Differen | 2012 |
Valproic acid as a therapeutic agent for head and neck squamous cell carcinomas.
Topics: Acetylation; Aged; Antineoplastic Agents; Blotting, Western; Carcinoma, Squamous Cell; Cell Prolifer | 2009 |