valproic acid has been researched along with Cancer of Esophagus in 3 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid (VPA) is a well-known drug used to treat seizure disorders and epilepsy, and has been shown to inhibit HDACs." | 1.42 | Inhibitory effects of valproic acid in DNA double-strand break repair after irradiation in esophageal squamous carcinoma cells. ( Fushida, S; Harada, S; Hayashi, H; Kinoshita, J; Makino, I; Makita, N; Miyashita, T; Nakagawara, H; Nakanuma, S; Ninomiya, I; Ohta, T; Okamoto, K; Oyama, K; Sakai, S; Tajima, H; Takamura, H; Tsukada, T, 2015) |
| "Valproic acid (VPA) has been used in clinical practice for the treatment of epilepsy and other seizure disorders and is also one of the most represented HDAC inhibitors." | 1.38 | Valproic acid, a histone deacetylase inhibitor, enhances radiosensitivity in esophageal squamous cell carcinoma. ( Fujimura, T; Fujita, H; Fushida, S; Harada, S; Kinoshita, J; Kitagawa, H; Makino, I; Nakagawara, H; Nakamura, K; Ninomiya, I; Ohta, T; Oyama, K; Shoji, M; Tajima, H; Takamura, H, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Makita, N | 1 |
| Ninomiya, I | 3 |
| Tsukada, T | 2 |
| Okamoto, K | 2 |
| Harada, S | 3 |
| Nakanuma, S | 2 |
| Sakai, S | 2 |
| Makino, I | 3 |
| Kinoshita, J | 3 |
| Hayashi, H | 2 |
| Oyama, K | 3 |
| Nakagawara, H | 2 |
| Miyashita, T | 2 |
| Tajima, H | 3 |
| Takamura, H | 3 |
| Fushida, S | 3 |
| Ohta, T | 3 |
| Kanamoto, A | 1 |
| Shoji, M | 1 |
| Nakamura, K | 1 |
| Fujita, H | 1 |
| Kitagawa, H | 1 |
| Fujimura, T | 1 |
3 other studies available for valproic acid and Cancer of Esophagus
| Article | Year |
|---|---|
Inhibitory effects of valproic acid in DNA double-strand break repair after irradiation in esophageal squamous carcinoma cells.
Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; DNA Breaks, Double-Stranded; DNA Repair; Esophageal Neop | 2015 |
Valproic acid inhibits irradiation-induced epithelial-mesenchymal transition and stem cell-like characteristics in esophageal squamous cell carcinoma.
Topics: Anticonvulsants; Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Cell Movement; Cell Prolife | 2016 |
Valproic acid, a histone deacetylase inhibitor, enhances radiosensitivity in esophageal squamous cell carcinoma.
Topics: Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; DNA Breaks, Double-Stranded; E | 2012 |