valproic acid has been researched along with Callous-Unemotional Traits in 12 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Children whose aggressive behavior persisted at the conclusion of the lead-in phase were randomly assigned to receive double-blind, flexibly dosed divalproex or a placebo adjunctive to stimulant for 8 weeks." | 2.74 | Adjunctive divalproex versus placebo for children with ADHD and aggression refractory to stimulant monotherapy. ( Blader, JC; Jensen, PS; Kafantaris, V; Pliszka, SR; Schooler, NR, 2009) |
| "Twelve had PTSD." | 2.73 | Divalproex sodium for the treatment of PTSD and conduct disordered youth: a pilot randomized controlled clinical trial. ( Carrion, V; Chang, K; Khanzode, LA; Saxena, KS; Silverman, M; Steiner, H, 2007) |
| "New treatments for conduct disorder are sorely needed." | 2.71 | Divalproex sodium for the treatment of conduct disorder: a randomized controlled clinical trial. ( Ford, S; Matthews, Z; Petersen, ML; Saxena, K; Steiner, H, 2003) |
| "Successful treatment of conduct disorder remains difficult." | 2.71 | Baseline predictors of response to divalproex in conduct disorder. ( Chang, K; Khanzode, L; Saxena, K; Silverman, MA; Steiner, H, 2005) |
| "All patients met DSM-IV criteria for a disruptive behavior disorder (oppositional defiant disorder of conduct disorder) in addition to research criteria." | 1.32 | "Outer-directed irritability": a distinct mood syndrome in explosive youth with a disruptive behavior disorder? ( Donovan, SJ; Jensen, PS; Klein, DF; Nunes, EV; Quitkin, FM; Ross, D; Stewart, JW, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 9 (75.00) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Blader, JC | 1 |
| Schooler, NR | 1 |
| Jensen, PS | 2 |
| Pliszka, SR | 1 |
| Kafantaris, V | 1 |
| Steiner, H | 6 |
| Karnik, NS | 1 |
| Padhy, R | 1 |
| Saxena, K | 4 |
| Remsing, L | 1 |
| Huemer, J | 1 |
| Plattner, B | 1 |
| Levy, T | 1 |
| Bloch, Y | 1 |
| Gérardin, P | 1 |
| Cohen, D | 1 |
| Mazet, P | 1 |
| Flament, MF | 1 |
| Donovan, SJ | 1 |
| Nunes, EV | 1 |
| Stewart, JW | 1 |
| Ross, D | 1 |
| Quitkin, FM | 1 |
| Klein, DF | 1 |
| Petersen, ML | 1 |
| Ford, S | 1 |
| Matthews, Z | 1 |
| Silverman, MA | 1 |
| Chang, K | 3 |
| Khanzode, L | 1 |
| Sugden, SG | 1 |
| Kile, SJ | 1 |
| Farrimond, DD | 1 |
| Hilty, DM | 1 |
| Bourgeois, JA | 1 |
| Khanzode, LA | 2 |
| Kraemer, H | 1 |
| Saxena, KS | 1 |
| Carrion, V | 1 |
| Silverman, M | 1 |
| Barinaga, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Double-Blind, Placebo-Controlled Trial of Flexible Dose Divalproex Sodium Adjunctive to Stimulant Treatment for Aggressive Children With Attention-Deficit Hyperactivity Disorder[NCT00228046] | Phase 4 | 40 participants (Anticipated) | Interventional | 2004-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for valproic acid and Callous-Unemotional Traits
| Article | Year |
|---|---|
[Pharmacotherapy for conduct disorder in children and adolescents].
Topics: Adolescent; Aggression; Anticoagulants; Antimanic Agents; Antipsychotic Agents; Attention Deficit Di | 2012 |
6 trials available for valproic acid and Callous-Unemotional Traits
| Article | Year |
|---|---|
Adjunctive divalproex versus placebo for children with ADHD and aggression refractory to stimulant monotherapy.
Topics: Adolescent; Aggression; Antimanic Agents; Attention Deficit and Disruptive Behavior Disorders; Atten | 2009 |
Symptomatic response to divalproex in subtypes of conduct disorder.
Topics: Adolescent; Aggression; Antimanic Agents; Conduct Disorder; Double-Blind Method; Humans; Male; Self | 2011 |
Divalproex sodium for the treatment of conduct disorder: a randomized controlled clinical trial.
Topics: Adolescent; Aggression; Anger; Anticonvulsants; Arousal; Conduct Disorder; Crime; Dose-Response Rela | 2003 |
Baseline predictors of response to divalproex in conduct disorder.
Topics: Adaptation, Psychological; Adolescent; Anticonvulsants; Comorbidity; Conduct Disorder; Defense Mecha | 2005 |
Efficacy profiles of psychopharmacology: divalproex sodium in conduct disorder.
Topics: Adolescent; Antidepressive Agents; Conduct Disorder; Double-Blind Method; Female; Humans; Male; Soci | 2006 |
Divalproex sodium for the treatment of PTSD and conduct disordered youth: a pilot randomized controlled clinical trial.
Topics: Adolescent; Anticonvulsants; Comorbidity; Conduct Disorder; Dose-Response Relationship, Drug; Double | 2007 |
5 other studies available for valproic acid and Callous-Unemotional Traits
| Article | Year |
|---|---|
Integrated treatment of aggression in the context of ADHD in children refractory to stimulant monotherapy: a window into the future of child psychopharmacology.
Topics: Adolescent; Aggression; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimul | 2009 |
Drug treatment of conduct disorder in young people.
Topics: Adolescent; Adrenergic alpha-Agonists; Anticonvulsants; Antipsychotic Agents; Carbamazepine; Central | 2002 |
"Outer-directed irritability": a distinct mood syndrome in explosive youth with a disruptive behavior disorder?
Topics: Adolescent; Adult; Age Factors; Aggression; Anticonvulsants; Attention Deficit and Disruptive Behavi | 2003 |
Pharmacological intervention for cognitive deficits and aggression in frontal lobe injury.
Topics: Adult; Aggression; Amantadine; Cognition Disorders; Conduct Disorder; Donepezil; Frontal Lobe; Human | 2006 |
Research risks. California probes prison teens study.
Topics: Adolescent; California; Clinical Trials as Topic; Conduct Disorder; Ethics Committees, Research; Gov | 1999 |