valproic acid has been researched along with Brain Swelling in 21 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid (VA) has been shown to be neuroprotective in several experimental brain diseases." | 5.43 | Valproic Acid Pretreatment Reduces Brain Edema in a Rat Model of Surgical Brain Injury. ( Applegate, RL; Huang, L; Khatibi, NH; Krafft, P; Martin, RD; Rolland, W; Sherchan, P; Woo, W; Zhang, J, 2016) |
| "Its appearance on CT resembles subarachnoid hemorrhage despite the absence of subarachnoid blood." | 5.37 | Image in toxicology: Pseudo-subarachnoid hemorrhage in a case of severe valproic acid poisoning. ( Min, YG; Tse, ML, 2011) |
| "The aims of this report are to 1) present a rare case of fatal cerebral edema associated with late-onset ornithine transcarbamylase (OTC) deficiency in a juvenile male patient receiving valproic acid and 2) review the neuropathologic changes associated with the hyperammonemia." | 3.73 | Fatal cerebral edema from late-onset ornithine transcarbamylase deficiency in a juvenile male patient receiving valproic acid. ( Fraser, DD; Ramsay, DA; Rupar, CA; Singh, R; Thakur, V, 2006) |
| "Valproic acid (VA) has been shown to be neuroprotective in several experimental brain diseases." | 1.43 | Valproic Acid Pretreatment Reduces Brain Edema in a Rat Model of Surgical Brain Injury. ( Applegate, RL; Huang, L; Khatibi, NH; Krafft, P; Martin, RD; Rolland, W; Sherchan, P; Woo, W; Zhang, J, 2016) |
| " The symptoms of VHE were not correlated with the dosage and concentration of valproate." | 1.40 | [Clinical misdiagnosis analysis of valproate encephalopathy]. ( Chen, X; Su, Z; Wu, Z; Ye, S; Zhu, D; Zhuge, G, 2014) |
| "Its appearance on CT resembles subarachnoid hemorrhage despite the absence of subarachnoid blood." | 1.37 | Image in toxicology: Pseudo-subarachnoid hemorrhage in a case of severe valproic acid poisoning. ( Min, YG; Tse, ML, 2011) |
| "We describe a 27-year-old woman who developed encephalopathy and cerebral edema during treatment of refractory complex partial seizures that included acute administration of valproate (VPA) at a dosage of 35 mg/kg per day." | 1.30 | Valproate-associated carnitine deficiency and malignant cerebral edema in the absence of hepatic failure. ( Bunch, TS; Cibula, J; Gilmore, RL; Harman, E; Millington, DS; Triggs, WJ, 1997) |
| "He developed a massive cerebral edema, as proved by computerized tomography (CT)." | 1.27 | A case of valproate intoxication with excessive brain edema. ( Hintze, G; Klein, HH; Kreuzer, H; Prange, H, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (9.52) | 18.7374 |
| 1990's | 3 (14.29) | 18.2507 |
| 2000's | 8 (38.10) | 29.6817 |
| 2010's | 8 (38.10) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhu, D | 1 |
| Su, Z | 1 |
| Ye, S | 1 |
| Chen, X | 1 |
| Zhuge, G | 1 |
| Wu, Z | 1 |
| Hurri, L | 1 |
| Posti, J | 1 |
| Seppä, JM | 1 |
| Rauhala, E | 1 |
| Puustinen, J | 1 |
| Huang, L | 1 |
| Woo, W | 1 |
| Sherchan, P | 1 |
| Khatibi, NH | 1 |
| Krafft, P | 1 |
| Rolland, W | 1 |
| Applegate, RL | 1 |
| Martin, RD | 1 |
| Zhang, J | 1 |
| Domínguez-Fuentes, B | 1 |
| García-Gil, D | 1 |
| Romero-Palacios, A | 1 |
| Sánchez-Crespo, JM | 1 |
| García-Arjona, R | 1 |
| Navarro-Navarro, J | 1 |
| Wang, Z | 1 |
| Leng, Y | 1 |
| Tsai, LK | 1 |
| Leeds, P | 1 |
| Chuang, DM | 1 |
| Rupasinghe, J | 1 |
| Jasinarachchi, M | 1 |
| Min, YG | 1 |
| Tse, ML | 1 |
| Senthilkumaran, S | 1 |
| Balamurugan, N | 1 |
| Menezes, RG | 1 |
| Thirumalaikolundusubramanian, P | 1 |
| Pittermann, P | 1 |
| Gabriel, S | 1 |
| Röschke, J | 1 |
| Minville, V | 1 |
| Roche Tissot, C | 1 |
| Samii, K | 1 |
| Camilleri, C | 1 |
| Albertson, T | 1 |
| Offerman, S | 1 |
| Eyer, F | 1 |
| Felgenhauer, N | 1 |
| Gempel, K | 1 |
| Steimer, W | 1 |
| Gerbitz, KD | 1 |
| Zilker, T | 1 |
| Thakur, V | 1 |
| Rupar, CA | 1 |
| Ramsay, DA | 1 |
| Singh, R | 1 |
| Fraser, DD | 1 |
| Segura-Bruna, N | 1 |
| Rodriguez-Campello, A | 1 |
| Puente, V | 1 |
| Roquer, J | 1 |
| Marklund, N | 1 |
| Enblad, P | 1 |
| Ronne-Engström, E | 1 |
| Unal, E | 1 |
| Kaya, U | 1 |
| Aydin, K | 1 |
| Berthelot-Moritz, F | 1 |
| Chadda, K | 1 |
| Chanavaz, I | 1 |
| Leroy, JP | 1 |
| Droy, JM | 1 |
| Bonmarchand, G | 1 |
| Leroy, J | 1 |
| Triggs, WJ | 1 |
| Gilmore, RL | 1 |
| Millington, DS | 1 |
| Cibula, J | 1 |
| Bunch, TS | 1 |
| Harman, E | 1 |
| Longmire, AW | 1 |
| Seger, DL | 1 |
| Bourrier, P | 1 |
| Varache, N | 1 |
| Alquier, P | 1 |
| Rabier, D | 1 |
| Kamoun, P | 1 |
| Lorre, G | 1 |
| Alhayek, G | 1 |
| Hintze, G | 1 |
| Klein, HH | 1 |
| Prange, H | 1 |
| Kreuzer, H | 1 |
1 review available for valproic acid and Brain Swelling
| Article | Year |
|---|---|
Valproate-induced hyperammonemic encephalopathy.
Topics: Anticonvulsants; Brain; Brain Edema; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carnitine | 2006 |
20 other studies available for valproic acid and Brain Swelling
| Article | Year |
|---|---|
[Clinical misdiagnosis analysis of valproate encephalopathy].
Topics: Anticonvulsants; Brain Diseases; Brain Edema; Brain Neoplasms; Diagnostic Errors; Epilepsy; Humans; | 2014 |
[Cerebral oedema caused by sodium valproate].
Topics: Anticonvulsants; Brain Edema; Carnitine; Combined Modality Therapy; Critical Care; Humans; Renal Dia | 2014 |
Valproic Acid Pretreatment Reduces Brain Edema in a Rat Model of Surgical Brain Injury.
Topics: Animals; Behavior, Animal; Brain; Brain Edema; Brain Injuries; Disease Models, Animal; Enzyme Inhibi | 2016 |
[Posterior reversible leukoencephalopathy in a patient with postpartum eclampsia].
Topics: Adult; Anticonvulsants; Antihypertensive Agents; Brain; Brain Edema; Cesarean Section; Diazepam; Dru | 2008 |
Valproic acid attenuates blood-brain barrier disruption in a rat model of transient focal cerebral ischemia: the roles of HDAC and MMP-9 inhibition.
Topics: Animals; Blood-Brain Barrier; Blotting, Western; Body Water; Brain Chemistry; Brain Edema; Butyrates | 2011 |
Progressive encephalopathy with cerebral oedema and infarctions associated with valproate and diazepam overdose.
Topics: Adult; Antimanic Agents; Brain Edema; Brain Infarction; Chemical and Drug Induced Liver Injury; Coma | 2011 |
Image in toxicology: Pseudo-subarachnoid hemorrhage in a case of severe valproic acid poisoning.
Topics: Anticonvulsants; Brain Edema; Drug Overdose; False Positive Reactions; Humans; Male; Predictive Valu | 2011 |
Role of Hounsfield units to distinguish pseudo-subarachnoid hemorrhage.
Topics: Anticonvulsants; Brain Edema; Drug Overdose; Humans; Subarachnoid Hemorrhage; Time Factors; Valproic | 2011 |
[Delirium caused by nonconvulsive status epilepticus].
Topics: Affect; Aged; Anticonvulsants; Antipsychotic Agents; Brain Edema; Confusion; Delirium; Dibenzothiaze | 2012 |
[Haemodialysis, L-carnitine therapy and valproic acid overdose].
Topics: Adult; Anticonvulsants; Antidotes; Brain Edema; Carnitine; Drug Overdose; Humans; Male; Renal Dialys | 2004 |
Fatal cerebral edema after moderate valproic acid overdose.
Topics: Adult; Ammonia; Brain Edema; Cyclohexanols; Drug Overdose; Fatal Outcome; Humans; Male; Risperidone; | 2005 |
Acute valproate poisoning: pharmacokinetics, alteration in fatty acid metabolism, and changes during therapy.
Topics: Anticonvulsants; Brain Edema; Carnitine; Drug Overdose; Fatty Acids; Female; Humans; Hyperammonemia; | 2005 |
Fatal cerebral edema from late-onset ornithine transcarbamylase deficiency in a juvenile male patient receiving valproic acid.
Topics: Adolescent; Brain Edema; Fatal Outcome; GABA Agents; Humans; Hyperammonemia; Male; Ornithine Carbamo | 2006 |
Neurointensive care management of raised intracranial pressure caused by severe valproic acid intoxication.
Topics: Adult; Anticonvulsants; Brain Edema; Critical Care; Epilepsy, Tonic-Clonic; Humans; Intracranial Hyp | 2007 |
Fatal valproate overdose in a newborn baby.
Topics: Anticonvulsants; Brain Edema; Drug Overdose; Fatal Outcome; Female; Heart Arrest; Humans; Infant, Ne | 2007 |
Fatal sodium valproate poisoning.
Topics: Adult; Anticonvulsants; Brain Edema; Drug Overdose; Fatal Outcome; Humans; Male; Valproic Acid | 1997 |
Valproate-associated carnitine deficiency and malignant cerebral edema in the absence of hepatic failure.
Topics: Adult; Anticonvulsants; Brain Edema; Carnitine; Epilepsy, Complex Partial; Fatal Outcome; Female; Hu | 1997 |
Cerebral edema from valproate?
Topics: Brain Edema; Humans; Hypoxia, Brain; Male; Valproic Acid | 1992 |
[Cerebral edema with hyperammonemia in valpromide poisoning. Manifestation in an adult, of a partial deficit in type I carbamylphosphate synthetase].
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Ammonia; Anticonvulsants; Brain Edema; Carbamoyl-Phosph | 1988 |
A case of valproate intoxication with excessive brain edema.
Topics: Adult; Brain Edema; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electroencephalogra | 1987 |