valproic acid has been researched along with Brain Injuries, Traumatic in 30 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Brain Injuries, Traumatic: A form of acquired brain injury which occurs when a sudden trauma causes damage to the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Histone deacetylase inhibitors such as valproic acid (VPA) improve survival in lethal models of hemorrhagic shock and polytrauma." | 7.88 | Rapid valproic acid-induced modulation of the traumatic proteome in a porcine model of traumatic brain injury and hemorrhagic shock. ( Alam, HB; Dennahy, IS; Georgoff, PE; Ghandour, MH; Higgins, GA; Nikolian, VC; Remmer, H; Weykamp, M, 2018) |
| "Valproic acid-treated animals had significantly less neurologic impairment on days 2 (16." | 7.30 | Prolonging the therapeutic window for valproic acid treatment in a swine model of traumatic brain injury and hemorrhagic shock. ( Alam, HB; Chtraklin, K; Dimonte, D; Ho, JW; Jin, G; Joaquin, TA; Keeney-Bonthrone, TP; Latif, Z; Ober, RA; Pai, MP; Vercruysse, C; Wen, B, 2023) |
| "Valproic acid-treated animals demonstrated significantly less neurologic impairment on PID 1 and returned to baseline faster (PID 1 mean neurologic severity score, control = 22 ± 3 vs." | 5.62 | Administration of valproic acid in clinically approved dose improves neurologic recovery and decreases brain lesion size in swine subjected to hemorrhagic shock and traumatic brain injury. ( Alam, HB; Bhatti, UF; Biesterveld, BE; Chtraklin, K; Kemp, MT; O'Connell, RL; Pai, MP; Siddiqui, AZ; Srinivasan, A; Vercruysse, CA; Wakam, GK; Williams, AM, 2021) |
| "Combined traumatic brain injury and hemorrhagic shock are highly lethal." | 5.48 | Improvement of Blood-Brain Barrier Integrity in Traumatic Brain Injury and Hemorrhagic Shock Following Treatment With Valproic Acid and Fresh Frozen Plasma. ( Alam, HB; Andjelkovic, AV; Bambakidis, T; Dekker, SE; Dennahy, IS; Georgoff, PE; Higgins, GA; Nikolian, VC; Williams, AM, 2018) |
| "Valproic acid-treated animals demonstrated significantly less neurologic impairment between PID 1 to 5 and smaller brain lesions on PID 3 (mean lesion size ± SEM, mm: ISCS = 4,956 ± 1,511 versus ISCS + VPA = 828 ± 279; p = 0." | 5.46 | Valproic acid decreases brain lesion size and improves neurologic recovery in swine subjected to traumatic brain injury, hemorrhagic shock, and polytrauma. ( Alam, HB; Chtraklin, K; Dennahy, IS; Eidy, H; Georgoff, PE; Ghandour, MH; Han, Y; Li, Y; Nikolian, VC; Pai, MP; Srinivasan, A, 2017) |
| "Traumatic brain injury and hemorrhagic shock (TBI+HS) elicit a complex inflammatory response that contributes to secondary brain injury." | 5.43 | Resuscitation with Valproic Acid Alters Inflammatory Genes in a Porcine Model of Combined Traumatic Brain Injury and Hemorrhagic Shock. ( Alam, HB; Bambakidis, T; de Vries, HE; Dekker, SE; Jin, G; Johnson, CN; Li, Y; Liu, B; Sillesen, M, 2016) |
| "We previously showed that the addition of valproic acid (VPA), a histone deacetylase inhibitor, to fresh frozen plasma (FFP) resuscitation attenuates brain lesion size and swelling following traumatic brain injury (TBI) and hemorrhagic shock (HS)." | 4.02 | Modulation of Brain Transcriptome by Combined Histone Deacetylase Inhibition and Plasma Treatment Following Traumatic Brain Injury and Hemorrhagic Shock. ( Alam, HB; Bambakidis, T; Biesterveld, BE; Dekker, SE; Johnson, CN; Li, Y; Liu, B; Sillesen, M; Tagett, R; Williams, AM, 2021) |
| " The histone deacetylase inhibitor, high-dose valproic acid (VPA) has been shown to have cytoprotective potential in models of combined TBI and hemorrhagic shock, but it has not been tested in an isolated TBI model." | 3.96 | Valproic acid treatment rescues injured tissues after traumatic brain injury. ( Alam, HB; Biesterveld, BE; Iancu, A; Kemp, MT; O'Connell, RL; Pai, MP; Pumiglia, L; Remmer, HA; Shamshad, AA; Siddiqui, AZ; Wakam, GK; Williams, AM, 2020) |
| "Histone deacetylase inhibitors such as valproic acid (VPA) improve survival in lethal models of hemorrhagic shock and polytrauma." | 3.88 | Rapid valproic acid-induced modulation of the traumatic proteome in a porcine model of traumatic brain injury and hemorrhagic shock. ( Alam, HB; Dennahy, IS; Georgoff, PE; Ghandour, MH; Higgins, GA; Nikolian, VC; Remmer, H; Weykamp, M, 2018) |
| "To determine the mechanism of action of valproic acid (VPA) in the adult central nervous system (CNS) following traumatic brain injury (TBI) and hemorrhagic shock (HS)." | 3.85 | Network Reconstruction Reveals that Valproic Acid Activates Neurogenic Transcriptional Programs in Adult Brain Following Traumatic Injury. ( Alam, HE; Allyn-Feuer, A; Athey, BD; Georgoff, P; Higgins, GA; Higgins, R; Nikolian, V; Pauls, B, 2017) |
| "Valproic acid-treated animals had significantly less neurologic impairment on days 2 (16." | 3.30 | Prolonging the therapeutic window for valproic acid treatment in a swine model of traumatic brain injury and hemorrhagic shock. ( Alam, HB; Chtraklin, K; Dimonte, D; Ho, JW; Jin, G; Joaquin, TA; Keeney-Bonthrone, TP; Latif, Z; Ober, RA; Pai, MP; Vercruysse, C; Wen, B, 2023) |
| "Valproic acid (VPA) treatment improves survival in animal models of injuries on doses higher than those allowed by Food and Drug Administration (FDA)." | 3.01 | Assessment of the Cytoprotective Effects of High-Dose Valproic Acid Compared to a Clinically Used Lower Dose. ( Alam, HB; Bhatti, UF; Biesterveld, BE; Kemp, M; Li, Y; Liu, B; Remmer, H; Russo, R; Tagett, R; Wakam, G; Williams, AM, 2021) |
| "Traumatic brain injury is a major health and socioeconomic problem and the first cause of young death worldwide." | 1.62 | The effect of antiepileptic drugs on re-myelinization of axons: Phenytoin, levetiracetam, carbamazepine, and valproic acid, used following traumatic brain injury. ( Demirci, H; Emmez, H; Gülbahar, Ö; Kuzucu, P; Özişik, P; Seymen, CM, 2021) |
| "Valproic acid-treated animals demonstrated significantly better neuroseverity scores on postinjury 1 (control, 9." | 1.62 | A single dose of valproic acid improves neurologic recovery and decreases brain lesion size in swine subjected to an isolated traumatic brain injury. ( Alam, HB; Biesterveld, BE; Chtraklin, K; Kemp, MT; O'Connell, RL; Pai, MP; Rajanayake, KK; Vercruysse, CA; Wakam, GK, 2021) |
| "Valproic acid (VPA) has been shown to attenuate brain lesion size and swelling within the first few hours following TBI." | 1.62 | Pharmacologic modulation of brain metabolism by valproic acid can induce a neuroprotective environment. ( Alam, HB; Bhatti, UF; Biesterveld, BE; Dennahy, IS; Kachman, M; Karnovsky, A; Li, Y; Liu, B; Nikolian, VC; O'Connell, RL; Siddiqui, A; Williams, AM, 2021) |
| "Valproic acid-treated animals demonstrated significantly less neurologic impairment on PID 1 and returned to baseline faster (PID 1 mean neurologic severity score, control = 22 ± 3 vs." | 1.62 | Administration of valproic acid in clinically approved dose improves neurologic recovery and decreases brain lesion size in swine subjected to hemorrhagic shock and traumatic brain injury. ( Alam, HB; Bhatti, UF; Biesterveld, BE; Chtraklin, K; Kemp, MT; O'Connell, RL; Pai, MP; Siddiqui, AZ; Srinivasan, A; Vercruysse, CA; Wakam, GK; Williams, AM, 2021) |
| "Combined traumatic brain injury and hemorrhagic shock are highly lethal." | 1.48 | Improvement of Blood-Brain Barrier Integrity in Traumatic Brain Injury and Hemorrhagic Shock Following Treatment With Valproic Acid and Fresh Frozen Plasma. ( Alam, HB; Andjelkovic, AV; Bambakidis, T; Dekker, SE; Dennahy, IS; Georgoff, PE; Higgins, GA; Nikolian, VC; Williams, AM, 2018) |
| "Valproic acid-treated animals demonstrated significantly less neurologic impairment between PID 1 to 5 and smaller brain lesions on PID 3 (mean lesion size ± SEM, mm: ISCS = 4,956 ± 1,511 versus ISCS + VPA = 828 ± 279; p = 0." | 1.46 | Valproic acid decreases brain lesion size and improves neurologic recovery in swine subjected to traumatic brain injury, hemorrhagic shock, and polytrauma. ( Alam, HB; Chtraklin, K; Dennahy, IS; Eidy, H; Georgoff, PE; Ghandour, MH; Han, Y; Li, Y; Nikolian, VC; Pai, MP; Srinivasan, A, 2017) |
| "Valproic acid (VPA) is a first-line antiepileptic drug, though its metabolism is affected by genetic polymorphisms and varies between individuals." | 1.46 | Early post-traumatic seizures are associated with valproic acid plasma concentrations and UGT1A6/CYP2C9 genetic polymorphisms in patients with severe traumatic brain injury. ( Hu, J; Sun, Y; Wu, X; Yu, J; Yuan, Q, 2017) |
| "Traumatic brain injury and hemorrhagic shock (TBI+HS) elicit a complex inflammatory response that contributes to secondary brain injury." | 1.43 | Resuscitation with Valproic Acid Alters Inflammatory Genes in a Porcine Model of Combined Traumatic Brain Injury and Hemorrhagic Shock. ( Alam, HB; Bambakidis, T; de Vries, HE; Dekker, SE; Jin, G; Johnson, CN; Li, Y; Liu, B; Sillesen, M, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 15 (50.00) | 24.3611 |
| 2020's | 15 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Demirci, H | 1 |
| Kuzucu, P | 1 |
| Seymen, CM | 1 |
| Gülbahar, Ö | 1 |
| Özişik, P | 1 |
| Emmez, H | 1 |
| Chen, A | 1 |
| Sharoha, N | 1 |
| Wakam, GK | 3 |
| Biesterveld, BE | 8 |
| Pai, MP | 6 |
| Kemp, MT | 3 |
| O'Connell, RL | 4 |
| Rajanayake, KK | 1 |
| Chtraklin, K | 5 |
| Vercruysse, CA | 2 |
| Alam, HB | 18 |
| Beresford, T | 1 |
| Ronan, PJ | 1 |
| Hipp, D | 1 |
| Schmidt, B | 1 |
| Thumm, EB | 1 |
| Temple, B | 1 |
| Wortzel, H | 1 |
| Weitzenkamp, D | 1 |
| Emrick, C | 1 |
| Kelly, J | 1 |
| Arciniegas, DB | 1 |
| Woolley, B | 1 |
| Mills, J | 1 |
| Liu, S | 1 |
| Tian, H | 1 |
| Niu, Y | 1 |
| Yu, C | 1 |
| Xie, L | 2 |
| Jin, Z | 1 |
| Niu, W | 1 |
| Ren, J | 1 |
| Fu, L | 1 |
| Yao, Z | 1 |
| Liu, Z | 1 |
| Zhu, L | 1 |
| Sheng, LP | 1 |
| Huang, QC | 1 |
| Qian, T | 1 |
| Qi, BX | 1 |
| Jin, G | 2 |
| Ho, JW | 1 |
| Keeney-Bonthrone, TP | 1 |
| Wen, B | 1 |
| Ober, RA | 1 |
| Dimonte, D | 1 |
| Joaquin, TA | 1 |
| Latif, Z | 1 |
| Vercruysse, C | 1 |
| Williams, AM | 11 |
| Dennahy, IS | 8 |
| Graham, NJ | 1 |
| Siddiqui, AZ | 3 |
| OʼConnell, RL | 1 |
| Bhatti, UF | 7 |
| Liu, B | 6 |
| Russo, RM | 1 |
| Li, Y | 7 |
| Georgoff, PE | 5 |
| Zheng, Z | 1 |
| Wu, Y | 1 |
| Li, Z | 1 |
| Ye, L | 1 |
| Lu, Q | 1 |
| Zhou, Y | 1 |
| Yuan, Y | 1 |
| Jiang, T | 1 |
| Liu, Y | 1 |
| Chen, D | 1 |
| Ye, J | 1 |
| Nimlamool, W | 1 |
| Zhang, H | 1 |
| Xiao, J | 1 |
| Russo, R | 2 |
| Kemp, M | 2 |
| Pai, M | 1 |
| Wakam, G | 2 |
| Biesterveld, B | 1 |
| Pumiglia, L | 1 |
| Iancu, A | 1 |
| Shamshad, AA | 1 |
| Remmer, HA | 1 |
| Dekker, SE | 4 |
| Bambakidis, T | 4 |
| Tagett, R | 2 |
| Johnson, CN | 2 |
| Sillesen, M | 3 |
| Karnovsky, A | 1 |
| Kachman, M | 1 |
| Nikolian, VC | 8 |
| Siddiqui, A | 1 |
| Srinivasan, A | 2 |
| Remmer, H | 2 |
| Eidy, H | 2 |
| Ghandour, MH | 3 |
| Han, Y | 1 |
| Welling, LC | 1 |
| Welling, MS | 1 |
| Figueiredo, EG | 1 |
| Schober, P | 1 |
| Sun, Y | 1 |
| Yu, J | 1 |
| Yuan, Q | 1 |
| Wu, X | 2 |
| Hu, J | 1 |
| Higgins, GA | 4 |
| Andjelkovic, AV | 1 |
| Weykamp, M | 3 |
| Chang, P | 2 |
| Korley, FK | 1 |
| Romoli, M | 1 |
| Mazzocchetti, P | 1 |
| D'Alonzo, R | 1 |
| Siliquini, S | 1 |
| Rinaldi, VE | 1 |
| Verrotti, A | 1 |
| Calabresi, P | 1 |
| Costa, C | 1 |
| Lee, J | 1 |
| Jorge, RE | 1 |
| Li, R | 1 |
| Liu, X | 1 |
| McGavin, JK | 1 |
| Shorter, DI | 1 |
| Acion, L | 1 |
| Arndt, S | 1 |
| de Vries, HE | 1 |
| Georgoff, P | 1 |
| Nikolian, V | 1 |
| Allyn-Feuer, A | 1 |
| Pauls, B | 1 |
| Higgins, R | 1 |
| Athey, BD | 1 |
| Alam, HE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| PSG in Valproate-induced Nocturnal Enuresis in Children[NCT04191863] | 260 participants (Actual) | Observational | 2018-09-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for valproic acid and Brain Injuries, Traumatic
| Article | Year |
|---|---|
The 'Omics' of Epigenetic Modulation by Valproic Acid Treatment in Traumatic Brain Injury-What We Know and What the Future Holds.
Topics: Animals; Brain Injuries, Traumatic; Epigenesis, Genetic; Gene Regulatory Networks; Genomics; Humans; | 2019 |
Life on the battlefield: Valproic acid for combat applications.
Topics: Animals; Armed Conflicts; Brain Injuries, Traumatic; Gene Expression; Histone Deacetylase Inhibitors | 2020 |
Different resuscitation strategies and novel pharmacologic treatment with valproic acid in traumatic brain injury.
Topics: Acetylation; Brain Injuries, Traumatic; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Humans; | 2018 |
Valproic Acid and Epilepsy: From Molecular Mechanisms to Clinical Evidences.
Topics: Animals; Anticonvulsants; Brain Injuries, Traumatic; Epilepsy; Histone Deacetylases; Humans; Neurons | 2019 |
4 trials available for valproic acid and Brain Injuries, Traumatic
| Article | Year |
|---|---|
A Double-Blind Placebo-Controlled, Randomized Trial of Divalproex Sodium for Posttraumatic Irritability Greater Than 1 Year After Mild to Moderate Traumatic Brain Injury.
Topics: Alcoholism; Brain Injuries, Traumatic; Double-Blind Method; Humans; Irritable Mood; Treatment Outcom | 2022 |
Prolonging the therapeutic window for valproic acid treatment in a swine model of traumatic brain injury and hemorrhagic shock.
Topics: Animals; Brain Injuries, Traumatic; Disease Models, Animal; Resuscitation; Saline Solution; Shock, H | 2023 |
Assessment of the Cytoprotective Effects of High-Dose Valproic Acid Compared to a Clinically Used Lower Dose.
Topics: Adolescent; Adult; Aged; Biomarkers; Brain Injuries, Traumatic; Chromatography, Liquid; Dose-Respons | 2021 |
Treating Alcohol Use Disorder in U.S. Veterans: The Role of Traumatic Brain Injury.
Topics: Adult; Alcohol Deterrents; Alcoholism; Brain Injuries, Traumatic; Comorbidity; Double-Blind Method; | 2019 |
22 other studies available for valproic acid and Brain Injuries, Traumatic
| Article | Year |
|---|---|
The effect of antiepileptic drugs on re-myelinization of axons: Phenytoin, levetiracetam, carbamazepine, and valproic acid, used following traumatic brain injury.
Topics: Animals; Anticonvulsants; Axons; Brain Injuries, Traumatic; Carbamazepine; Levetiracetam; Phenytoin; | 2021 |
Valproate Efficacy for Agitation Management in a Patient With Paroxysmal Sympathetic Hyperactivity Due to Traumatic Brain Injury.
Topics: Brain Injuries, Traumatic; Humans; Psychomotor Agitation; Valproic Acid | 2021 |
A single dose of valproic acid improves neurologic recovery and decreases brain lesion size in swine subjected to an isolated traumatic brain injury.
Topics: Animals; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Female; Humans; Resuscitation; Su | 2021 |
Versatile Valproic Acid.
Topics: Brain Injuries, Traumatic; Delirium; Humans; Valproic Acid | 2022 |
Combined cell grafting and VPA administration facilitates neural repair through axonal regeneration and synaptogenesis in traumatic brain injury.
Topics: Animals; Axons; Brain Injuries, Traumatic; Mice; N-Methylaspartate; Neural Stem Cells; Neurons; Valp | 2022 |
[A pilot study on the effects of early use of valproate sodium on neuroinflammation after traumatic brain injury].
Topics: Brain Injuries, Traumatic; Child; HMGB1 Protein; Humans; Neuroinflammatory Diseases; NLR Family, Pyr | 2023 |
Dose optimization of valproic acid in a lethal model of traumatic brain injury, hemorrhage, and multiple trauma in swine.
Topics: Animals; Brain Injuries, Traumatic; Disease Models, Animal; Dose-Response Relationship, Drug; Erythr | 2019 |
Valproic acid affects neuronal fate and microglial function via enhancing autophagic flux in mice after traumatic brain injury.
Topics: Animals; Autophagy; Brain Injuries, Traumatic; Male; Maze Learning; Mice; Mice, Inbred C57BL; Microg | 2020 |
Valproic acid treatment rescues injured tissues after traumatic brain injury.
Topics: Animals; Biomarkers; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Female; Glial Fibrill | 2020 |
Modulation of Brain Transcriptome by Combined Histone Deacetylase Inhibition and Plasma Treatment Following Traumatic Brain Injury and Hemorrhagic Shock.
Topics: Animals; Blood Component Transfusion; Brain Injuries, Traumatic; Disease Models, Animal; Enzyme Inhi | 2021 |
Pharmacologic modulation of brain metabolism by valproic acid can induce a neuroprotective environment.
Topics: Animals; Brain Injuries, Traumatic; Disease Models, Animal; Female; Histone Deacetylase Inhibitors; | 2021 |
Administration of valproic acid in clinically approved dose improves neurologic recovery and decreases brain lesion size in swine subjected to hemorrhagic shock and traumatic brain injury.
Topics: Animals; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Dose-Response Relationship, Drug; | 2021 |
Valproic acid decreases brain lesion size and improves neurologic recovery in swine subjected to traumatic brain injury, hemorrhagic shock, and polytrauma.
Topics: Animals; Brain; Brain Injuries, Traumatic; Cognition; Disease Models, Animal; Enzyme Inhibitors; Fem | 2017 |
Traumatic Brain Injury and Mood Stabilizers: Recent Cumulative Evidence.
Topics: Antimanic Agents; Brain Injuries, Traumatic; Humans; Lithium Chloride; Valproic Acid | 2017 |
Early post-traumatic seizures are associated with valproic acid plasma concentrations and UGT1A6/CYP2C9 genetic polymorphisms in patients with severe traumatic brain injury.
Topics: Adult; Aged; Anticonvulsants; Brain Injuries, Traumatic; Case-Control Studies; Cytochrome P-450 CYP2 | 2017 |
Improvement of Blood-Brain Barrier Integrity in Traumatic Brain Injury and Hemorrhagic Shock Following Treatment With Valproic Acid and Fresh Frozen Plasma.
Topics: Animals; Blood-Brain Barrier; Brain Injuries, Traumatic; Disease Models, Animal; Endothelium, Vascul | 2018 |
Transcriptomic changes following valproic acid treatment promote neurogenesis and minimize secondary brain injury.
Topics: Animals; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Female; GABA Agents; Neurons; Pol | 2018 |
Valproic Acid Treatment Decreases Serum Glial Fibrillary Acidic Protein and Neurofilament Light Chain Levels in Swine Subjected to Traumatic Brain Injury.
Topics: Animals; Biomarkers; Brain Injuries, Traumatic; Female; Glial Fibrillary Acidic Protein; Neurofilame | 2018 |
Rapid valproic acid-induced modulation of the traumatic proteome in a porcine model of traumatic brain injury and hemorrhagic shock.
Topics: Animals; Brain Injuries, Traumatic; Disease Models, Animal; Female; Histone Deacetylase Inhibitors; | 2018 |
Valproic Acid and Neural Apoptosis, Inflammation, and Degeneration 30 Days after Traumatic Brain Injury, Hemorrhagic Shock, and Polytrauma in a Swine Model.
Topics: Animals; Apoptosis; Brain Injuries, Traumatic; Disease Models, Animal; Female; Histone Deacetylase I | 2019 |
Resuscitation with Valproic Acid Alters Inflammatory Genes in a Porcine Model of Combined Traumatic Brain Injury and Hemorrhagic Shock.
Topics: Animals; Brain; Brain Injuries, Traumatic; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Fem | 2016 |
Network Reconstruction Reveals that Valproic Acid Activates Neurogenic Transcriptional Programs in Adult Brain Following Traumatic Injury.
Topics: Adult; Animals; Anticonvulsants; Brain; Brain Injuries, Traumatic; Cell Line, Tumor; Gene Expression | 2017 |