valproic acid has been researched along with Brain Edema in 21 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid (VA) has been shown to be neuroprotective in several experimental brain diseases." | 5.43 | Valproic Acid Pretreatment Reduces Brain Edema in a Rat Model of Surgical Brain Injury. ( Applegate, RL; Huang, L; Khatibi, NH; Krafft, P; Martin, RD; Rolland, W; Sherchan, P; Woo, W; Zhang, J, 2016) |
| "Its appearance on CT resembles subarachnoid hemorrhage despite the absence of subarachnoid blood." | 5.37 | Image in toxicology: Pseudo-subarachnoid hemorrhage in a case of severe valproic acid poisoning. ( Min, YG; Tse, ML, 2011) |
| "The aims of this report are to 1) present a rare case of fatal cerebral edema associated with late-onset ornithine transcarbamylase (OTC) deficiency in a juvenile male patient receiving valproic acid and 2) review the neuropathologic changes associated with the hyperammonemia." | 3.73 | Fatal cerebral edema from late-onset ornithine transcarbamylase deficiency in a juvenile male patient receiving valproic acid. ( Fraser, DD; Ramsay, DA; Rupar, CA; Singh, R; Thakur, V, 2006) |
| "Valproic acid (VA) has been shown to be neuroprotective in several experimental brain diseases." | 1.43 | Valproic Acid Pretreatment Reduces Brain Edema in a Rat Model of Surgical Brain Injury. ( Applegate, RL; Huang, L; Khatibi, NH; Krafft, P; Martin, RD; Rolland, W; Sherchan, P; Woo, W; Zhang, J, 2016) |
| " The symptoms of VHE were not correlated with the dosage and concentration of valproate." | 1.40 | [Clinical misdiagnosis analysis of valproate encephalopathy]. ( Chen, X; Su, Z; Wu, Z; Ye, S; Zhu, D; Zhuge, G, 2014) |
| "Its appearance on CT resembles subarachnoid hemorrhage despite the absence of subarachnoid blood." | 1.37 | Image in toxicology: Pseudo-subarachnoid hemorrhage in a case of severe valproic acid poisoning. ( Min, YG; Tse, ML, 2011) |
| "We describe a 27-year-old woman who developed encephalopathy and cerebral edema during treatment of refractory complex partial seizures that included acute administration of valproate (VPA) at a dosage of 35 mg/kg per day." | 1.30 | Valproate-associated carnitine deficiency and malignant cerebral edema in the absence of hepatic failure. ( Bunch, TS; Cibula, J; Gilmore, RL; Harman, E; Millington, DS; Triggs, WJ, 1997) |
| "He developed a massive cerebral edema, as proved by computerized tomography (CT)." | 1.27 | A case of valproate intoxication with excessive brain edema. ( Hintze, G; Klein, HH; Kreuzer, H; Prange, H, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (9.52) | 18.7374 |
| 1990's | 3 (14.29) | 18.2507 |
| 2000's | 8 (38.10) | 29.6817 |
| 2010's | 8 (38.10) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhu, D | 1 |
| Su, Z | 1 |
| Ye, S | 1 |
| Chen, X | 1 |
| Zhuge, G | 1 |
| Wu, Z | 1 |
| Hurri, L | 1 |
| Posti, J | 1 |
| Seppä, JM | 1 |
| Rauhala, E | 1 |
| Puustinen, J | 1 |
| Huang, L | 1 |
| Woo, W | 1 |
| Sherchan, P | 1 |
| Khatibi, NH | 1 |
| Krafft, P | 1 |
| Rolland, W | 1 |
| Applegate, RL | 1 |
| Martin, RD | 1 |
| Zhang, J | 1 |
| Domínguez-Fuentes, B | 1 |
| García-Gil, D | 1 |
| Romero-Palacios, A | 1 |
| Sánchez-Crespo, JM | 1 |
| García-Arjona, R | 1 |
| Navarro-Navarro, J | 1 |
| Wang, Z | 1 |
| Leng, Y | 1 |
| Tsai, LK | 1 |
| Leeds, P | 1 |
| Chuang, DM | 1 |
| Rupasinghe, J | 1 |
| Jasinarachchi, M | 1 |
| Min, YG | 1 |
| Tse, ML | 1 |
| Senthilkumaran, S | 1 |
| Balamurugan, N | 1 |
| Menezes, RG | 1 |
| Thirumalaikolundusubramanian, P | 1 |
| Pittermann, P | 1 |
| Gabriel, S | 1 |
| Röschke, J | 1 |
| Minville, V | 1 |
| Roche Tissot, C | 1 |
| Samii, K | 1 |
| Camilleri, C | 1 |
| Albertson, T | 1 |
| Offerman, S | 1 |
| Eyer, F | 1 |
| Felgenhauer, N | 1 |
| Gempel, K | 1 |
| Steimer, W | 1 |
| Gerbitz, KD | 1 |
| Zilker, T | 1 |
| Thakur, V | 1 |
| Rupar, CA | 1 |
| Ramsay, DA | 1 |
| Singh, R | 1 |
| Fraser, DD | 1 |
| Segura-Bruna, N | 1 |
| Rodriguez-Campello, A | 1 |
| Puente, V | 1 |
| Roquer, J | 1 |
| Marklund, N | 1 |
| Enblad, P | 1 |
| Ronne-Engström, E | 1 |
| Unal, E | 1 |
| Kaya, U | 1 |
| Aydin, K | 1 |
| Berthelot-Moritz, F | 1 |
| Chadda, K | 1 |
| Chanavaz, I | 1 |
| Leroy, JP | 1 |
| Droy, JM | 1 |
| Bonmarchand, G | 1 |
| Leroy, J | 1 |
| Triggs, WJ | 1 |
| Gilmore, RL | 1 |
| Millington, DS | 1 |
| Cibula, J | 1 |
| Bunch, TS | 1 |
| Harman, E | 1 |
| Longmire, AW | 1 |
| Seger, DL | 1 |
| Bourrier, P | 1 |
| Varache, N | 1 |
| Alquier, P | 1 |
| Rabier, D | 1 |
| Kamoun, P | 1 |
| Lorre, G | 1 |
| Alhayek, G | 1 |
| Hintze, G | 1 |
| Klein, HH | 1 |
| Prange, H | 1 |
| Kreuzer, H | 1 |
1 review available for valproic acid and Brain Edema
| Article | Year |
|---|---|
Valproate-induced hyperammonemic encephalopathy.
Topics: Anticonvulsants; Brain; Brain Edema; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carnitine | 2006 |
20 other studies available for valproic acid and Brain Edema
| Article | Year |
|---|---|
[Clinical misdiagnosis analysis of valproate encephalopathy].
Topics: Anticonvulsants; Brain Diseases; Brain Edema; Brain Neoplasms; Diagnostic Errors; Epilepsy; Humans; | 2014 |
[Cerebral oedema caused by sodium valproate].
Topics: Anticonvulsants; Brain Edema; Carnitine; Combined Modality Therapy; Critical Care; Humans; Renal Dia | 2014 |
Valproic Acid Pretreatment Reduces Brain Edema in a Rat Model of Surgical Brain Injury.
Topics: Animals; Behavior, Animal; Brain; Brain Edema; Brain Injuries; Disease Models, Animal; Enzyme Inhibi | 2016 |
[Posterior reversible leukoencephalopathy in a patient with postpartum eclampsia].
Topics: Adult; Anticonvulsants; Antihypertensive Agents; Brain; Brain Edema; Cesarean Section; Diazepam; Dru | 2008 |
Valproic acid attenuates blood-brain barrier disruption in a rat model of transient focal cerebral ischemia: the roles of HDAC and MMP-9 inhibition.
Topics: Animals; Blood-Brain Barrier; Blotting, Western; Body Water; Brain Chemistry; Brain Edema; Butyrates | 2011 |
Progressive encephalopathy with cerebral oedema and infarctions associated with valproate and diazepam overdose.
Topics: Adult; Antimanic Agents; Brain Edema; Brain Infarction; Chemical and Drug Induced Liver Injury; Coma | 2011 |
Image in toxicology: Pseudo-subarachnoid hemorrhage in a case of severe valproic acid poisoning.
Topics: Anticonvulsants; Brain Edema; Drug Overdose; False Positive Reactions; Humans; Male; Predictive Valu | 2011 |
Role of Hounsfield units to distinguish pseudo-subarachnoid hemorrhage.
Topics: Anticonvulsants; Brain Edema; Drug Overdose; Humans; Subarachnoid Hemorrhage; Time Factors; Valproic | 2011 |
[Delirium caused by nonconvulsive status epilepticus].
Topics: Affect; Aged; Anticonvulsants; Antipsychotic Agents; Brain Edema; Confusion; Delirium; Dibenzothiaze | 2012 |
[Haemodialysis, L-carnitine therapy and valproic acid overdose].
Topics: Adult; Anticonvulsants; Antidotes; Brain Edema; Carnitine; Drug Overdose; Humans; Male; Renal Dialys | 2004 |
Fatal cerebral edema after moderate valproic acid overdose.
Topics: Adult; Ammonia; Brain Edema; Cyclohexanols; Drug Overdose; Fatal Outcome; Humans; Male; Risperidone; | 2005 |
Acute valproate poisoning: pharmacokinetics, alteration in fatty acid metabolism, and changes during therapy.
Topics: Anticonvulsants; Brain Edema; Carnitine; Drug Overdose; Fatty Acids; Female; Humans; Hyperammonemia; | 2005 |
Fatal cerebral edema from late-onset ornithine transcarbamylase deficiency in a juvenile male patient receiving valproic acid.
Topics: Adolescent; Brain Edema; Fatal Outcome; GABA Agents; Humans; Hyperammonemia; Male; Ornithine Carbamo | 2006 |
Neurointensive care management of raised intracranial pressure caused by severe valproic acid intoxication.
Topics: Adult; Anticonvulsants; Brain Edema; Critical Care; Epilepsy, Tonic-Clonic; Humans; Intracranial Hyp | 2007 |
Fatal valproate overdose in a newborn baby.
Topics: Anticonvulsants; Brain Edema; Drug Overdose; Fatal Outcome; Female; Heart Arrest; Humans; Infant, Ne | 2007 |
Fatal sodium valproate poisoning.
Topics: Adult; Anticonvulsants; Brain Edema; Drug Overdose; Fatal Outcome; Humans; Male; Valproic Acid | 1997 |
Valproate-associated carnitine deficiency and malignant cerebral edema in the absence of hepatic failure.
Topics: Adult; Anticonvulsants; Brain Edema; Carnitine; Epilepsy, Complex Partial; Fatal Outcome; Female; Hu | 1997 |
Cerebral edema from valproate?
Topics: Brain Edema; Humans; Hypoxia, Brain; Male; Valproic Acid | 1992 |
[Cerebral edema with hyperammonemia in valpromide poisoning. Manifestation in an adult, of a partial deficit in type I carbamylphosphate synthetase].
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Ammonia; Anticonvulsants; Brain Edema; Carbamoyl-Phosph | 1988 |
A case of valproate intoxication with excessive brain edema.
Topics: Adult; Brain Edema; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electroencephalogra | 1987 |