valproic acid has been researched along with Bone Fractures in 7 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| " After adjustment for prior fracture, use (ever) of corticosteroids, comorbidity, social variables, and diagnosis of epilepsy, carbamazepine [CBZ; odds ratio (OR), 1." | 3.72 | Fracture risk associated with use of antiepileptic drugs. ( Mosekilde, L; Rejnmark, L; Vestergaard, P, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Merschin, D | 1 |
| Kerling, F | 1 |
| Winterholler, M | 1 |
| Stangl, R | 1 |
| Rauchenzauner, M | 1 |
| Griesmacher, A | 1 |
| Tatarczyk, T | 1 |
| Haberlandt, E | 1 |
| Strasak, A | 1 |
| Zimmerhackl, LB | 1 |
| Falkensammer, G | 1 |
| Luef, G | 1 |
| Högler, W | 1 |
| Leonard, H | 1 |
| Downs, J | 1 |
| Jian, L | 1 |
| Bebbington, A | 1 |
| Jacoby, P | 1 |
| Nagarajan, L | 1 |
| Ravine, D | 1 |
| Woodhead, H | 1 |
| Avery, TR | 1 |
| Kulldorff, M | 1 |
| Vilk, Y | 1 |
| Li, L | 1 |
| Cheetham, TC | 1 |
| Dublin, S | 1 |
| Davis, RL | 1 |
| Liu, L | 1 |
| Herrinton, L | 1 |
| Brown, JS | 1 |
| Vestergaard, P | 1 |
| Rejnmark, L | 1 |
| Mosekilde, L | 1 |
| Pavlakis, SG | 1 |
| Chusid, RL | 1 |
| Roye, DP | 1 |
| Nordli, DR | 1 |
| Scott, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of the Treatment of Vitamin D Deficiency in Drug-resistant Epilepsy[NCT03475225] | Phase 3 | 400 participants (Anticipated) | Interventional | 2018-04-30 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 other studies available for valproic acid and Bone Fractures
| Article | Year |
|---|---|
[Epilepsy and transverse sternum fractures: sternum fractures in drug-induced osteopenia].
Topics: Adult; Anticonvulsants; Bone Diseases, Metabolic; Bone Plates; Epilepsy; Female; Fracture Fixation, | 2014 |
Chronic antiepileptic monotherapy, bone metabolism, and body composition in non-institutionalized children.
Topics: Anthropometry; Anticonvulsants; Body Composition; Body Height; Body Mass Index; Body Weight; Carbama | 2010 |
Valproate and risk of fracture in Rett syndrome.
Topics: Adolescent; Adult; Anticonvulsants; Australia; Child; Child, Preschool; Drug Administration Schedule | 2010 |
Near real-time adverse drug reaction surveillance within population-based health networks: methodology considerations for data accrual.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Anticonvulsants; Child; Drugs, Generic; | 2013 |
Fracture risk associated with use of antiepileptic drugs.
Topics: Adult; Anticonvulsants; Bone Density; Carbamazepine; Case-Control Studies; Denmark; Epilepsy; Female | 2004 |
Valproate therapy: predisposition to bone fracture?
Topics: Adolescent; Bone and Bones; Disease Susceptibility; Epilepsy; Female; Femoral Fractures; Foot; Fract | 1998 |
Fracture blisters and sodium valproate: two case reports.
Topics: Adult; Ankle Injuries; Anticonvulsants; Blister; Drug Eruptions; Fractures, Bone; Humans; Male; Valp | 2000 |