valproic acid has been researched along with Blood Pressure, High in 19 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study determined whether infusion of valproic acid (VA), an agent known to stimulate the stem cell function, attenuated salt-sensitive hypertension in Dahl S rats." | 7.85 | Infusion of Valproic Acid Into the Renal Medulla Activates Stem Cell Population and Attenuates Salt-Sensitive Hypertension in Dahl S Rats. ( Boini, KM; Li, N; Li, PL; Wang, W; Wang, Z; Yi, F; Zhu, Q, 2017) |
| "VPA prevented HFD-induced hypertension by downregulating angiotensin II and its receptor via inhibition of HDAC1, offering a novel therapeutic option for HFD-induced hypertension." | 7.85 | Role of the histone deacetylase inhibitor valproic acid in high-fat diet-induced hypertension via inhibition of HDAC1/angiotensin II axis. ( Choi, J; Kim, JI; Kwon, TK; Park, KM; Park, S; Sohn, SI, 2017) |
| "Elevated circulating uric acid has been postulated to play an important pathophysiological role in estrogen-progestin combined oral contraceptive (COC)-induced hypertension and endothelial dysfunction." | 3.88 | Inhibition of adenosine deaminase and xanthine oxidase by valproic acid abates hepatic triglyceride accumulation independent of corticosteroids in female rats treated with estrogen-progestin. ( Areola, ED; Badmus, OO; Kim, I; Michael, OS; Olatunji, LA; Omolekulo, TE, 2018) |
| " This study determined whether infusion of valproic acid (VA), an agent known to stimulate the stem cell function, attenuated salt-sensitive hypertension in Dahl S rats." | 3.85 | Infusion of Valproic Acid Into the Renal Medulla Activates Stem Cell Population and Attenuates Salt-Sensitive Hypertension in Dahl S Rats. ( Boini, KM; Li, N; Li, PL; Wang, W; Wang, Z; Yi, F; Zhu, Q, 2017) |
| "VPA prevented HFD-induced hypertension by downregulating angiotensin II and its receptor via inhibition of HDAC1, offering a novel therapeutic option for HFD-induced hypertension." | 3.85 | Role of the histone deacetylase inhibitor valproic acid in high-fat diet-induced hypertension via inhibition of HDAC1/angiotensin II axis. ( Choi, J; Kim, JI; Kwon, TK; Park, KM; Park, S; Sohn, SI, 2017) |
| " We included patients who had a diagnosis of bipolar disorder and were prescribed lithium (n = 2148), valproate (n = 1670), olanzapine (n = 1477), or quetiapine (n = 1376) as maintenance mood stabilizer treatment." | 3.83 | Adverse Renal, Endocrine, Hepatic, and Metabolic Events during Maintenance Mood Stabilizer Treatment for Bipolar Disorder: A Population-Based Cohort Study. ( Geddes, JR; Hayes, JF; King, M; Marston, L; Osborn, DP; Walters, K, 2016) |
| "The present study was aimed to investigate the antihyperlipidemic and renoprotective potential of valproic acid against N(ω)-nitro-L arginine methyl ester hydrochloride (L-NAME) induced hypertension in male albino Wistar rats." | 3.80 | Valproic acid prevents the deregulation of lipid metabolism and renal renin-angiotensin system in L-NAME induced nitric oxide deficient hypertensive rats. ( Dhanalakshmi, T; Manivannan, J; Raja, B; Rajeshwari, T; Silambarasan, T, 2014) |
| " The aim of the current study was to evaluate the effects of losartan (2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'(1H-tetrazol-5-yl)-biphenil-4-yl)methyl]imidazole) and telmisartan (49-[(1,49-dimethyl-29-propyl[2,69-bi-1H-benzimidazo]-19-yl)methyl]-[1,19-biphenyl]-2-carboxylic acid), the angiotensin AT1 receptor antagonists which are widely used in clinical practice, on the protective action of conventional antiepileptic drugs (carbamazepine, phenytoin, valproate and phenobarbital) against maximal electroshock-induced seizures in mice." | 3.76 | Angiotensin AT1 receptor antagonists enhance the anticonvulsant action of valproate in the mouse model of maximal electroshock. ( Czuczwar, SJ; Jakubus, T; Janowska, A; Tochman-Gawda, A; Łukawski, K, 2010) |
| " Another set of rats were treated with hydralazine (25 mg/kg per day orally) to determine the pressure-independent effects of HDAC inhibition on hypertension." | 3.76 | HDAC inhibition attenuates inflammatory, hypertrophic, and hypertensive responses in spontaneously hypertensive rats. ( Cardinale, JP; Elks, CM; Francis, J; Guggilam, A; Mariappan, N; Pariaut, R; Sriramula, S, 2010) |
| "To determine whether chronic central gamma-aminobutyric acid (GABA) stimulation would attenuate development of hypertension, tail-cuff systolic pressures were measured in male spontaneously hypertensive rats (SHR) treated with either an inhibitor of GABA breakdown (valproate, VPA), or a GABA-receptor agonist (muscimol)." | 3.68 | Chronic central GABAergic stimulation attenuates hypothalamic hyperactivity and development of spontaneous hypertension in rats. ( Hayashi, J; Kawasaki, S; Nakagawa, M; Nakata, T; Oguro, M; Sasaki, S; Takeda, K, 1990) |
| " Intraperitoneal injection of valproic acid (50-100 mg/Kg/die) for 6 weeks significantly reduced the development of DOCA-salt hypertension in rats." | 3.67 | Increased cardiovascular responsiveness to GABAergic stimulation in DOCA-salt hypertensive rats. ( Caputi, AP; Costa, G; Di Giorgio, RM; Magrì, V; Quattrone, G; Squadrito, F; Trimarchi, GR, 1984) |
| "The causes of hypertension are complex and involve both genetic and environmental factors." | 1.56 | The Role of DNMT and HDACs in the Fetal Programming of Hypertension by Glucocorticoids. ( Byrne, CJ; Khaper, N; Khurana, S; Lamothe, J; Mercier, S; Tai, TC; Tharmalingam, S; Williamson, C, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (21.05) | 18.7374 |
| 1990's | 2 (10.53) | 18.2507 |
| 2000's | 2 (10.53) | 29.6817 |
| 2010's | 10 (52.63) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Lamothe, J | 1 |
| Khurana, S | 1 |
| Tharmalingam, S | 1 |
| Williamson, C | 1 |
| Byrne, CJ | 1 |
| Khaper, N | 1 |
| Mercier, S | 1 |
| Tai, TC | 1 |
| Wang, Z | 1 |
| Zhu, Q | 1 |
| Wang, W | 1 |
| Yi, F | 1 |
| Li, PL | 1 |
| Boini, KM | 1 |
| Li, N | 1 |
| Choi, J | 1 |
| Park, S | 2 |
| Kwon, TK | 1 |
| Sohn, SI | 1 |
| Park, KM | 2 |
| Kim, JI | 1 |
| Omolekulo, TE | 1 |
| Areola, ED | 1 |
| Badmus, OO | 1 |
| Michael, OS | 1 |
| Kim, I | 1 |
| Olatunji, LA | 1 |
| Kee, HJ | 1 |
| Bae, EH | 1 |
| Lee, KE | 1 |
| Suh, SH | 1 |
| Kim, SW | 1 |
| Jeong, MH | 1 |
| Rajeshwari, T | 1 |
| Raja, B | 1 |
| Manivannan, J | 1 |
| Silambarasan, T | 1 |
| Dhanalakshmi, T | 1 |
| Seok, YM | 1 |
| Lee, HA | 1 |
| Hwangbo, MH | 1 |
| Kim, IK | 1 |
| Hayes, JF | 1 |
| Marston, L | 1 |
| Walters, K | 1 |
| Geddes, JR | 1 |
| King, M | 1 |
| Osborn, DP | 1 |
| Baumann, M | 1 |
| Janssen, BJ | 1 |
| Rob Hermans, JJ | 1 |
| Bartholome, R | 1 |
| Smits, JF | 1 |
| Struijker Boudier, HA | 1 |
| Verrotti, A | 1 |
| Manco, R | 1 |
| Agostinelli, S | 1 |
| Coppola, G | 1 |
| Chiarelli, F | 1 |
| Łukawski, K | 1 |
| Janowska, A | 1 |
| Jakubus, T | 1 |
| Tochman-Gawda, A | 1 |
| Czuczwar, SJ | 1 |
| Cardinale, JP | 1 |
| Sriramula, S | 1 |
| Pariaut, R | 1 |
| Guggilam, A | 1 |
| Mariappan, N | 1 |
| Elks, CM | 1 |
| Francis, J | 1 |
| Arnold, G | 1 |
| Schuh-Hofer, S | 1 |
| Magrì, V | 1 |
| Trimarchi, GR | 1 |
| Quattrone, G | 1 |
| Squadrito, F | 1 |
| Di Giorgio, RM | 1 |
| Costa, G | 1 |
| Caputi, AP | 2 |
| Rotiroti, D | 1 |
| Palella, B | 1 |
| Losi, E | 1 |
| Nistico, G | 1 |
| Meerson, FZ | 1 |
| Gimrikh, EO | 1 |
| Gutsol, LIa | 1 |
| Popov, SV | 1 |
| Plekhanov, IG | 1 |
| Sasaki, S | 1 |
| Nakata, T | 1 |
| Kawasaki, S | 1 |
| Hayashi, J | 1 |
| Oguro, M | 1 |
| Takeda, K | 1 |
| Nakagawa, M | 1 |
| Feely, M | 1 |
| Cooke, J | 1 |
| Price, D | 1 |
| Singleton, S | 1 |
| Mehta, A | 1 |
| Bradford, L | 1 |
| Calvert, R | 1 |
| Lefkowitz, D | 1 |
| Harpold, G | 1 |
1 review available for valproic acid and Blood Pressure, High
| Article | Year |
|---|---|
[Comorbidities in migraine patients].
Topics: Adult; Amitriptyline; Analgesics, Non-Narcotic; Anticonvulsants; Anxiety Disorders; Carotid Artery, | 2007 |
18 other studies available for valproic acid and Blood Pressure, High
| Article | Year |
|---|---|
The Role of DNMT and HDACs in the Fetal Programming of Hypertension by Glucocorticoids.
Topics: Animals; Blood Pressure; Decitabine; Dexamethasone; DNA (Cytosine-5-)-Methyltransferases; Epigenesis | 2020 |
Infusion of Valproic Acid Into the Renal Medulla Activates Stem Cell Population and Attenuates Salt-Sensitive Hypertension in Dahl S Rats.
Topics: AC133 Antigen; Animals; Antihypertensive Agents; Enzyme Inhibitors; Fibroblast Growth Factor 2; Hype | 2017 |
Role of the histone deacetylase inhibitor valproic acid in high-fat diet-induced hypertension via inhibition of HDAC1/angiotensin II axis.
Topics: Angiotensin II; Animals; Blotting, Western; Diet, High-Fat; Disease Models, Animal; Histone Deacetyl | 2017 |
Inhibition of adenosine deaminase and xanthine oxidase by valproic acid abates hepatic triglyceride accumulation independent of corticosteroids in female rats treated with estrogen-progestin.
Topics: Adenosine Deaminase; Adenosine Deaminase Inhibitors; Aldosterone; Animals; Contraceptives, Oral, Com | 2018 |
HDAC inhibition suppresses cardiac hypertrophy and fibrosis in DOCA-salt hypertensive rats via regulation of HDAC6/HDAC8 enzyme activity.
Topics: Animals; Cardiomegaly; Desoxycorticosterone Acetate; Disease Models, Animal; Enzyme Activation; Fibr | 2013 |
Valproic acid prevents the deregulation of lipid metabolism and renal renin-angiotensin system in L-NAME induced nitric oxide deficient hypertensive rats.
Topics: Animals; Antihypertensive Agents; Catalase; Glutathione; Glutathione Peroxidase; Hypertension; Hypol | 2014 |
Lysine deacetylase inhibition attenuates hypertension and is accompanied by acetylation of mineralocorticoid receptor instead of histone acetylation in spontaneously hypertensive rats.
Topics: Acetylation; Age Factors; Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; | 2016 |
Adverse Renal, Endocrine, Hepatic, and Metabolic Events during Maintenance Mood Stabilizer Treatment for Bipolar Disorder: A Population-Based Cohort Study.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Cardiovascular Diseases; Chemical an | 2016 |
Renal medullary effects of transient prehypertensive treatment in young spontaneously hypertensive rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Apoptosis; Blood Pressure | 2009 |
The metabolic syndrome in overweight epileptic patients treated with valproic acid.
Topics: Adolescent; Anticonvulsants; Body Mass Index; Cardiovascular Diseases; Child; Comorbidity; Dyslipide | 2010 |
Angiotensin AT1 receptor antagonists enhance the anticonvulsant action of valproate in the mouse model of maximal electroshock.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Anticonvulsants; Behavior, Animal; Benzimidazoles; | 2010 |
HDAC inhibition attenuates inflammatory, hypertrophic, and hypertensive responses in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Echocardiography; Histone Deacetylas | 2010 |
Increased cardiovascular responsiveness to GABAergic stimulation in DOCA-salt hypertensive rats.
Topics: 4-Aminobutyrate Transaminase; Animals; Blood Pressure; Brain; Desoxycorticosterone; Ethanolamines; g | 1984 |
Evidence that a GABAergic mechanism influences the development of DOCA-salt hypertension in the rat.
Topics: Animals; Blood Pressure; Body Weight; Desoxycorticosterone; gamma-Aminobutyric Acid; Hypertension; M | 1982 |
[The anti-arrhythmic efficacy of sodium valproate].
Topics: Adolescent; Adult; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Drug Evaluation; Electrocar | 1992 |
Chronic central GABAergic stimulation attenuates hypothalamic hyperactivity and development of spontaneous hypertension in rats.
Topics: Animals; Blood Pressure; Electric Stimulation; gamma-Aminobutyric Acid; Heart Rate; Hemodynamics; Hy | 1990 |
Low-dose phenobarbitone as an indicator of compliance with drug therapy.
Topics: Adult; Aged; Antihypertensive Agents; Female; Humans; Hypertension; Male; Middle Aged; Patient Compl | 1987 |
Treatment of ocular myoclonus with valproic acid.
Topics: Cerebral Hemorrhage; Eye Movements; Humans; Hypertension; Male; Middle Aged; Myoclonus; Oculomotor M | 1985 |