valproic acid has been researched along with Blood Diseases in 10 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Side effects of carbamazepine (CBZ), valproate (VPA) and clonazepam (CZP) are rare during long-term use but rather common and usually transient during the early phases of treatment." | 5.27 | Side effects of carbamazepine, valproate and clonazepam during long-term treatment of epilepsy. ( Keränen, T; Sivenius, J, 1983) |
| " In children under 2 years old, serious adverse effects are appear to be more frequent." | 1.51 | Adverse Effects of Treatment with Valproic Acid during the Neonatal Period. ( Baudou, E; Benevent, J; Hachon LeCamus, C; Montastruc, JL; Touati, G, 2019) |
| "Side effects of carbamazepine (CBZ), valproate (VPA) and clonazepam (CZP) are rare during long-term use but rather common and usually transient during the early phases of treatment." | 1.27 | Side effects of carbamazepine, valproate and clonazepam during long-term treatment of epilepsy. ( Keränen, T; Sivenius, J, 1983) |
| "Only 21% of those with myoclonic astatic epilepsy have become free from seizures." | 1.26 | Sodium valproate: monotherapy and polytherapy. ( Covanis, A; Gupta, AK; Jeavons, PM, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (40.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Riahi-Zanjani, B | 1 |
| Delirrad, M | 1 |
| Fazeli-Bakhtiyari, R | 1 |
| Sadeghi, M | 1 |
| Zare-Zardini, H | 1 |
| Jafari, A | 1 |
| Ghorani-Azam, A | 1 |
| Baudou, E | 1 |
| Benevent, J | 1 |
| Montastruc, JL | 1 |
| Touati, G | 1 |
| Hachon LeCamus, C | 1 |
| Kuo, SC | 1 |
| Yeh, YW | 1 |
| Chen, CY | 1 |
| Yeh, CB | 1 |
| Tzeng, NS | 1 |
| Mao, WC | 1 |
| Vasudev, K | 1 |
| Keown, P | 1 |
| Gibb, I | 1 |
| McAllister-Williams, RH | 1 |
| Coulter, DW | 1 |
| Walko, C | 1 |
| Patel, J | 1 |
| Moats-Staats, BM | 1 |
| McFadden, A | 1 |
| Smith, SV | 1 |
| Khan, WA | 1 |
| Bridges, AS | 1 |
| Deal, AM | 1 |
| Oesterheld, J | 1 |
| Davis, IJ | 1 |
| Blatt, J | 1 |
| Keränen, T | 1 |
| Sivenius, J | 1 |
| Schmidt, D | 1 |
| Boillot, A | 1 |
| Bourgeois, F | 1 |
| Barale, F | 1 |
| Lenys, R | 1 |
| Daoudal, P | 1 |
| Delacour, JL | 1 |
| Covanis, A | 1 |
| Gupta, AK | 1 |
| Jeavons, PM | 1 |
| Park, BK | 1 |
| Pirmohamed, M | 1 |
| Kitteringham, NR | 1 |
2 reviews available for valproic acid and Blood Diseases
| Article | Year |
|---|---|
Hematological Consequences of Valproic Acid in Pediatric Patients: A Systematic Review with a Mechanistic Approach.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Female; Hematologic Diseases; Humans; Infant; | 2022 |
The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Chemical and Drug Induced Liver Injury; Cytochrome P-450 | 1995 |
1 trial available for valproic acid and Blood Diseases
| Article | Year |
|---|---|
Valproic acid reduces the tolerability of temsirolimus in children and adolescents with solid tumors.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Diphenhydramine | 2013 |
7 other studies available for valproic acid and Blood Diseases
| Article | Year |
|---|---|
Adverse Effects of Treatment with Valproic Acid during the Neonatal Period.
Topics: Anticonvulsants; Chemical and Drug Induced Liver Injury; Consciousness Disorders; Female; Hematologi | 2019 |
Repeated adverse hematologic reactions associated with valproic acid use in a patient with acquired renal insufficiency.
Topics: Female; GABA Agents; Hematologic Diseases; Humans; Middle Aged; Renal Insufficiency; Valproic Acid | 2013 |
Hematological effects of valproate in psychiatric patients: what are the risk factors?
Topics: Adolescent; Adult; Aged; Anemia, Macrocytic; Blood Cell Count; Cross-Sectional Studies; Female; Hema | 2010 |
Side effects of carbamazepine, valproate and clonazepam during long-term treatment of epilepsy.
Topics: Abnormalities, Drug-Induced; Arousal; Benzodiazepinones; Carbamazepine; Chemical and Drug Induced Li | 1983 |
Adverse effects of valproate.
Topics: Gastrointestinal Diseases; Hematologic Diseases; Humans; Mental Disorders; Metabolic Diseases; Nervo | 1984 |
[Fatal bone marrow involvement in voluntary acute poisoning with sodium dipropylacetate].
Topics: Adult; Hematologic Diseases; Humans; Male; Suicide; Valproic Acid | 1981 |
Sodium valproate: monotherapy and polytherapy.
Topics: Adolescent; Adult; Carbamazepine; Drug Therapy, Combination; Epilepsies, Myoclonic; Epilepsies, Part | 1982 |