valproic acid has been researched along with Blood Coagulation Disorders in 20 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Blood Coagulation Disorders: Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Four patients had pancreatitis associated with valproic acid therapy." | 7.67 | Pancreatitis associated with valproic acid therapy. ( Cruse, RP; Erenberg, G; Rothner, AD; Wyllie, E; Wyllie, R, 1984) |
| "Valproic acid (VPA) has been widely used more frequently as its approved indications have been expanded." | 5.62 | Rhabdomyolysis and Hepatotoxicity From Valproic Acid: Case Reports. ( Deb, S; Walker, CP, 2021) |
| " One hundred thirty-two patients at high risk for seizures were assigned to receive a 1-week course of phenytoin, 120 were assigned to receive a 1-month course of valproate, and 127 were assigned to receive a 6-month course of valproate." | 5.09 | Valproate therapy for prevention of posttraumatic seizures: a randomized trial. ( Anderson, GD; Awan, A; Cohen, W; Dikmen, SS; Holmes, MD; Nelson, P; Newell, DW; Temkin, NR; Wilensky, AJ; Winn, HR, 1999) |
| "Four patients had pancreatitis associated with valproic acid therapy." | 3.67 | Pancreatitis associated with valproic acid therapy. ( Cruse, RP; Erenberg, G; Rothner, AD; Wyllie, E; Wyllie, R, 1984) |
| "Valproic acid (VPA) is a frequently prescribed anti-epileptic drug." | 1.72 | Assessment of need for hemostatic evaluation in patients taking valproic acid: A retrospective cross-sectional study. ( Beckers, EAM; Henskens, YMC; Heubel-Moenen, FCJI; Klinkenberg, S; Post, DS; Rijkers, K; Schijns, OEMG; van der Veer, A; van Kranen-Mastenbroek, VHJM; Verhezen, PWM; Wagner, GL; Willems, PCPH, 2022) |
| "Valproic acid (VPA) has been widely used more frequently as its approved indications have been expanded." | 1.62 | Rhabdomyolysis and Hepatotoxicity From Valproic Acid: Case Reports. ( Deb, S; Walker, CP, 2021) |
| "Valproic acid (VPA) is an antiepileptic drug that has been associated with impaired hemostasis and increased risk for postsurgical bleeding." | 1.42 | Effects of chronic administration of valproic acid to epileptic patients on coagulation tests and primary hemostasis. ( Canevini, MP; Cattaneo, M; Chiesa, V; Fontana, G; Lussana, F; Vignoli, A; Zighetti, ML, 2015) |
| "After treatment with levetiracetam, seizures recurred and intravenous loading with valproic acid was administered, but resulted in a rapid increase in international normalized ratio (INR) to 7." | 1.37 | Valproic acid and warfarin: an underrecognized drug interaction. ( Giraldo, EA; Wijdicks, EF; Yoon, HW, 2011) |
| "Rett's syndrome is a neurodevelopmental disorder which is caused by a mutation on the x-chromosome; thus, it only affects the female sex." | 1.30 | [Rett's syndrome: pathophysiology and anesthesiological implications]. ( Häuser, FM; Lennartz, H; Lukasewitz, P; Wichert, A, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (25.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 5 (25.00) | 29.6817 |
| 2010's | 5 (25.00) | 24.3611 |
| 2020's | 3 (15.00) | 2.80 |
| Authors | Studies |
|---|---|
| Post, DS | 1 |
| van der Veer, A | 1 |
| Schijns, OEMG | 1 |
| Klinkenberg, S | 1 |
| Rijkers, K | 1 |
| Wagner, GL | 1 |
| van Kranen-Mastenbroek, VHJM | 1 |
| Willems, PCPH | 1 |
| Verhezen, PWM | 1 |
| Beckers, EAM | 1 |
| Heubel-Moenen, FCJI | 1 |
| Henskens, YMC | 1 |
| Zhu, R | 1 |
| Wang, Q | 1 |
| Zhou, Y | 1 |
| Shi, W | 1 |
| Zhang, Y | 1 |
| Wang, M | 1 |
| Li, H | 1 |
| Zhao, R | 1 |
| Walker, CP | 1 |
| Deb, S | 1 |
| Kumar, R | 1 |
| Vidaurre, J | 1 |
| Gedela, S | 1 |
| Amathieu, R | 1 |
| Levesque, E | 1 |
| Merle, JC | 1 |
| Chemit, M | 1 |
| Costentin, C | 1 |
| Compagnon, P | 1 |
| Dhonneur, G | 1 |
| Abdallah, C | 1 |
| Zighetti, ML | 1 |
| Fontana, G | 1 |
| Lussana, F | 1 |
| Chiesa, V | 1 |
| Vignoli, A | 1 |
| Canevini, MP | 1 |
| Cattaneo, M | 1 |
| Köse, G | 1 |
| Arhan, E | 1 |
| Unal, B | 1 |
| Ozaydin, E | 1 |
| Guven, A | 1 |
| Sayli, TR | 1 |
| Yoon, HW | 1 |
| Giraldo, EA | 1 |
| Wijdicks, EF | 1 |
| Banerjea, MC | 1 |
| Diener, W | 1 |
| Kutschke, G | 1 |
| Schneble, HJ | 1 |
| Korinthenberg, R | 1 |
| Sutor, AH | 1 |
| Attilakos, A | 1 |
| Katsarou, E | 1 |
| Voudris, K | 1 |
| Garoufi, A | 1 |
| Gerstner, T | 1 |
| Bauer, MO | 1 |
| Longin, E | 1 |
| Bell, N | 1 |
| Koenig, SA | 1 |
| Wyllie, E | 1 |
| Wyllie, R | 1 |
| Cruse, RP | 1 |
| Erenberg, G | 1 |
| Rothner, AD | 1 |
| Koch-Weser, J | 1 |
| Browne, TR | 1 |
| Smith, FR | 1 |
| Boots, M | 1 |
| Loisseau, P | 1 |
| Martínez-Lage, JM | 1 |
| Temkin, NR | 1 |
| Dikmen, SS | 1 |
| Anderson, GD | 1 |
| Wilensky, AJ | 1 |
| Holmes, MD | 1 |
| Cohen, W | 1 |
| Newell, DW | 1 |
| Nelson, P | 1 |
| Awan, A | 1 |
| Winn, HR | 1 |
| Häuser, FM | 1 |
| Lukasewitz, P | 1 |
| Wichert, A | 1 |
| Lennartz, H | 1 |
| Heckmann, JG | 1 |
| Tomandl, B | 1 |
| Erbguth, F | 1 |
| Neidhardt, B | 1 |
| Zingsem, H | 1 |
| Neundörfer, B | 1 |
| Monnet, P | 1 |
| David, M | 1 |
| Philippe, N | 1 |
| Dechavanne, M | 1 |
| Floret, D | 1 |
| Renaud, H | 1 |
| Trezeciak, MC | 1 |
| Brazier, JL | 1 |
| Bourdillon, D | 1 |
3 reviews available for valproic acid and Blood Coagulation Disorders
| Article | Year |
|---|---|
Valproic Acid-Induced Coagulopathy.
Topics: Anticonvulsants; Blood Coagulation Disorders; Hemostasis; Humans; Valproic Acid | 2019 |
[Severe toxic acute liver failure: etiology and treatment].
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Anti-Infective Agents; Blood Coagulation Disorde | 2013 |
Drug therapy: Valproic acid.
Topics: Adult; Alopecia; Behavior; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Chil | 1980 |
2 trials available for valproic acid and Blood Coagulation Disorders
| Article | Year |
|---|---|
Drug therapy: Valproic acid.
Topics: Adult; Alopecia; Behavior; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Chil | 1980 |
Valproate therapy for prevention of posttraumatic seizures: a randomized trial.
Topics: Adult; Anticonvulsants; Blood Coagulation Disorders; Brain Injuries; Chemical and Drug Induced Liver | 1999 |
16 other studies available for valproic acid and Blood Coagulation Disorders
| Article | Year |
|---|---|
Assessment of need for hemostatic evaluation in patients taking valproic acid: A retrospective cross-sectional study.
Topics: Adolescent; Adult; Aged; Blood Coagulation Disorders; Child; Child, Preschool; Cross-Sectional Studi | 2022 |
The prevalence and risk factors of coagulopathy in pediatric patients undergoing surgery for epilepsy.
Topics: Afibrinogenemia; Anticonvulsants; Blood Coagulation Disorders; Body Weight; Child; Epilepsy; Humans; | 2023 |
Rhabdomyolysis and Hepatotoxicity From Valproic Acid: Case Reports.
Topics: Adult; Anticonvulsants; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Female; | 2021 |
Valproic acid and acquired coagulopathy.
Topics: Anticonvulsants; Blood Coagulation Disorders; Child; Humans; Perioperative Care; Thrombocytopenia; V | 2013 |
Effects of chronic administration of valproic acid to epileptic patients on coagulation tests and primary hemostasis.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adolescent; Adult; Anticonvulsants; Blood Coagulation | 2015 |
Valproate-associated coagulopathies in children during short-term treatment.
Topics: Adolescent; Anticonvulsants; Biomarkers; Blood Coagulation Disorders; Blood Coagulation Factors; Blo | 2009 |
Valproic acid and warfarin: an underrecognized drug interaction.
Topics: Aged; Anticoagulants; Anticonvulsants; Blood Coagulation Disorders; Drug Interactions; Female; Human | 2011 |
Pro- and anticoagulatory factors under sodium valproate-therapy in children.
Topics: Adolescent; Adult; Blood Coagulation Disorders; Child; Child, Preschool; Epilepsies, Partial; Epilep | 2002 |
Valproate-associated coagulopathies are frequent and variable in children.
Topics: Age Factors; Ambulatory Care; Anticonvulsants; Blood Coagulation Disorders; Child; Epilepsy; Female; | 2007 |
Reversible hepatotoxicity, pancreatitis, coagulation disorder and simultaneous bone marrow suppression with valproate in a 2-year-old girl.
Topics: Blood Coagulation Disorders; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Child, Pr | 2007 |
Pancreatitis associated with valproic acid therapy.
Topics: Abdomen; Adolescent; Adult; Amylases; Blood Coagulation Disorders; Child; Child, Preschool; Female; | 1984 |
Sodium valproate and bone marrow suppression.
Topics: Adult; Blood Coagulation Disorders; Bone Marrow Diseases; Epilepsies, Partial; Female; Humans; Throm | 1980 |
[Clinical irrelevance of the hematologic side effects of sodium valproate (Depakine)].
Topics: Adult; Age Factors; Anticonvulsants; Autoantibodies; Blood Coagulation Disorders; Blood Platelets; C | 1981 |
[Rett's syndrome: pathophysiology and anesthesiological implications].
Topics: Adult; Anesthesia; Anticonvulsants; Blood Coagulation Disorders; Epilepsy; Female; Humans; Kidney Ca | 1999 |
Cerebral vein thrombosis and prothrombin gene (G20210A) mutation.
Topics: Adult; Age Factors; Aged; Blood Coagulation Disorders; Cerebral Veins; Female; Genetic Predispositio | 2001 |
[Alterations in hemostasis during treatment with sodium dipropylacetate (Depakine) (R)].
Topics: Blood Coagulation Disorders; Child; Child, Preschool; Female; Hemostasis; Humans; Infant; Male; Thro | 1979 |