Page last updated: 2024-10-26

valproic acid and Blood Clot

valproic acid has been researched along with Blood Clot in 5 studies

Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.

Research Excerpts

ExcerptRelevanceReference
" Thus, this study shows that VPA can be dosed to selectively manipulate the fibrinolytic system in the vascular compartment and reduce thrombus formation in vivo."1.43Valproic acid selectively increases vascular endothelial tissue-type plasminogen activator production and reduces thrombus formation in the mouse. ( Alwis, I; Bergh, N; Daglas, M; Fogelstrand, P; Glise, L; Jackson, SP; Jern, S; Larsson, P; Magnusson, M; Medcalf, RL; Niego, B; Sashindranath, M; Wu, MC, 2016)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's4 (80.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wang, J1
Mahmud, SA1
Bitterman, PB1
Huo, Y1
Slungaard, A1
Aebischer, B1
Elsig, S1
Taeymans, J1
Pomp, S1
Kuhness, D1
Barcaro, G1
Sementa, L1
Mankad, V1
Fortunelli, A1
Sterrer, M1
Netzer, FP1
Surnev, S1
Schmieder, AH1
Caruthers, SD1
Keupp, J1
Wickline, SA1
Lanza, GM1
Lowe, J1
Wodarcyk, AJ1
Floyd, KT1
Rastogi, N1
Schultz, EJ1
Swager, SA1
Chadwick, JA1
Tran, T1
Raman, SV1
Janssen, PM1
Rafael-Fortney, JA1
Alcalay, RN1
Levy, OA1
Wolf, P1
Oliva, P1
Zhang, XK1
Waters, CH1
Fahn, S1
Kang, U1
Liong, C1
Ford, B1
Mazzoni, P1
Kuo, S1
Johnson, A1
Xiong, L1
Rouleau, GA1
Chung, W1
Marder, KS1
Gan-Or, Z1
Kamei, K1
Terao, T1
Katayama, Y1
Hatano, K1
Kodama, K1
Shirahama, M1
Sakai, A1
Hirakawa, H1
Mizokami, Y1
Shiotsuki, I1
Ishii, N1
Inoue, Y1
Akboga, MK1
Yayla, C1
Balci, KG1
Ozeke, O1
Maden, O1
Kisacik, H1
Temizhan, A1
Aydogdu, S1
Zhu, J2
Ying, SH1
Feng, MG1
Zhang, XG1
Li, H1
Wang, L1
Hao, YY1
Liang, GD1
Ma, YH1
Yang, GS1
Hu, JH1
Pfeifer, L1
Goertz, RS1
Neurath, MF1
Strobel, D1
Wildner, D1
Lin, JT1
Yang, XN1
Zhong, WZ1
Liao, RQ1
Dong, S1
Nie, Q1
Weng, SX1
Fang, XJ1
Zheng, JY1
Wu, YL1
Řezanka, T1
Kaineder, K1
Mezricky, D1
Řezanka, M1
Bišová, K1
Zachleder, V1
Vítová, M1
Rinker, JA1
Marshall, SA1
Mazzone, CM1
Lowery-Gionta, EG1
Gulati, V1
Pleil, KE1
Kash, TL1
Navarro, M1
Thiele, TE1
Zhang, Y1
Huang, Y1
Jin, Z1
Li, X1
Li, B1
Xu, P1
Huang, P1
Liu, C1
Fokdal, L1
Sturdza, A1
Mazeron, R1
Haie-Meder, C1
Tan, LT1
Gillham, C1
Šegedin, B1
Jürgenliemk-Schultz, I1
Kirisits, C1
Hoskin, P1
Pötter, R1
Lindegaard, JC1
Tanderup, K1
Levin, DE1
Schmitz, AJ1
Hines, SM1
Hines, KJ1
Tucker, MJ1
Brewer, SH1
Fenlon, EE1
Álvarez-Pérez, S1
Blanco, JL1
Peláez, T1
Martínez-Nevado, E1
García, ME1
Puckerin, AA1
Chang, DD1
Subramanyam, P1
Colecraft, HM1
Dogan, H1
Coteli, E1
Karatas, F1
Ceylan, O1
Sahin, MD1
Akdamar, G1
Kryczyk, A1
Żmudzki, P1
Hubicka, U1
Giovannelli, D1
Chung, M1
Staley, J1
Starovoytov, V1
Le Bris, N1
Vetriani, C1
Chen, W1
Wu, L1
Liu, X1
Shen, Y1
Liang, Y1
Tan, H1
Yang, Y1
Liu, Q1
Wang, M1
Liu, L1
Wang, X1
Liu, B2
Liu, GH1
Zhu, YJ1
Wang, JP1
Che, JM1
Chen, QQ1
Chen, Z1
Maucksch, U1
Runge, R1
Wunderlich, G1
Freudenberg, R1
Naumann, A1
Kotzerke, J1
Larsson, P1
Alwis, I1
Niego, B1
Sashindranath, M1
Fogelstrand, P1
Wu, MC1
Glise, L1
Magnusson, M1
Daglas, M1
Bergh, N1
Jackson, SP1
Medcalf, RL1
Jern, S1
Bambakidis, T1
Dekker, SE1
Halaweish, I1
Nikolian, VC1
Georgoff, PE1
Piascik, P1
Li, Y1
Sillesen, M1
Alam, HB1
Nadkarni, A1
Oldham, M1
Howard, M1
Lazar, HL1
Berenbaum, I1

Reviews

1 review available for valproic acid and Blood Clot

ArticleYear
    Hand therapy, 2016, Volume: 21, Issue:1

    Topics: AC133 Antigen; Acenaphthenes; Acer; Acrosome Reaction; Adult; Agaricales; Aged; Aged, 80 and over; A

2016

Trials

1 trial available for valproic acid and Blood Clot

ArticleYear
Histone deacetylase inhibitors suppress TF-kappaB-dependent agonist-driven tissue factor expression in endothelial cells and monocytes.
    The Journal of biological chemistry, 2007, Sep-28, Volume: 282, Issue:39

    Topics: Acetylation; Cells, Cultured; E-Selectin; Endothelial Cells; Enzyme Induction; Enzyme Inhibitors; Hi

2007

Other Studies

3 other studies available for valproic acid and Blood Clot

ArticleYear
Valproic acid selectively increases vascular endothelial tissue-type plasminogen activator production and reduces thrombus formation in the mouse.
    Journal of thrombosis and haemostasis : JTH, 2016, Volume: 14, Issue:12

    Topics: Animals; Aorta; Blood Coagulation; Blood Platelets; Endothelium, Vascular; Enzyme Inhibitors; Fibrin

2016
Valproic acid modulates platelet and coagulation function ex vivo.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2017, Volume: 28, Issue:6

    Topics: Animals; Blood Coagulation; Blood Platelets; Brain Injuries; Platelet Aggregation; Shock, Hemorrhagi

2017
Detrimental effects of divalproex on warfarin therapy following mechanical valve replacement.
    Journal of cardiac surgery, 2011, Volume: 26, Issue:5

    Topics: Adult; Anticoagulants; Antimanic Agents; Bipolar Disorder; Drug Interactions; Drug Therapy, Combinat

2011