valproic acid has been researched along with Blast Crisis in 2 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Blast Crisis: An advanced phase of chronic myelogenous leukemia, characterized by a rapid increase in the proportion of immature white blood cells (blasts) in the blood and bone marrow to greater than 30%.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Haaland, I | 1 |
| Hjelle, SM | 1 |
| Reikvam, H | 1 |
| Sulen, A | 1 |
| Ryningen, A | 1 |
| McCormack, E | 1 |
| Bruserud, Ø | 1 |
| Gjertsen, BT | 1 |
| Poggi, A | 1 |
| Catellani, S | 1 |
| Garuti, A | 1 |
| Pierri, I | 1 |
| Gobbi, M | 1 |
| Zocchi, MR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Differentiation Induction Therapy for Acute Myelogenous Leukemia[NCT00175812] | Phase 1/Phase 2 | 24 participants (Actual) | Interventional | 2004-11-30 | Completed | ||
| Treatment of Acute Myelogenous Leukemia With the Histone Deacetylase Inhibitor Valproic Cid in Combination With All-trans Retinoic Acid (ATRA) and Low Dose Cytarabine[NCT00995332] | Phase 1/Phase 2 | 36 participants (Actual) | Interventional | 2009-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 other studies available for valproic acid and Blast Crisis
| Article | Year |
|---|---|
p53 Protein Isoform Profiles in AML: Correlation with Distinct Differentiation Stages and Response to Epigenetic Differentiation Therapy.
Topics: Adult; Aged; Aged, 80 and over; Blast Crisis; Cell Differentiation; Cell Line, Tumor; Epigenesis, Ge | 2021 |
p53 Protein Isoform Profiles in AML: Correlation with Distinct Differentiation Stages and Response to Epigenetic Differentiation Therapy.
Topics: Adult; Aged; Aged, 80 and over; Blast Crisis; Cell Differentiation; Cell Line, Tumor; Epigenesis, Ge | 2021 |
p53 Protein Isoform Profiles in AML: Correlation with Distinct Differentiation Stages and Response to Epigenetic Differentiation Therapy.
Topics: Adult; Aged; Aged, 80 and over; Blast Crisis; Cell Differentiation; Cell Line, Tumor; Epigenesis, Ge | 2021 |
p53 Protein Isoform Profiles in AML: Correlation with Distinct Differentiation Stages and Response to Epigenetic Differentiation Therapy.
Topics: Adult; Aged; Aged, 80 and over; Blast Crisis; Cell Differentiation; Cell Line, Tumor; Epigenesis, Ge | 2021 |
Effective in vivo induction of NKG2D ligands in acute myeloid leukaemias by all-trans-retinoic acid or sodium valproate.
Topics: Adult; Aged; Blast Crisis; Cytotoxicity, Immunologic; Female; GPI-Linked Proteins; Histone Deacetyla | 2009 |