valproic acid has been researched along with Bilirubinemia in 3 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Free bilirubin was not significantly changed by 50 mg/kg VPA-Na, but did show a significant transient elevation with the 200 mg/kg dose." | 5.30 | Effect of valproate on the pharmacokinetics of free and total plasma bilirubin in experimental hyperbilirubinemia in guinea pigs. ( Shen, YZ; Yu, HY, 1998) |
| " In addition, characterization of the UGT1A locus and genetic studies directed at understanding the role of bilirubin glucuronidation and the biochemical basis of the clinical symptoms found in unconjugated hyperbilirubinemia have uncovered the structural gene polymorphisms associated with Crigler-Najjar's and Gilbert's syndrome." | 4.80 | Human UDP-glucuronosyltransferases: metabolism, expression, and disease. ( Strassburg, CP; Tukey, RH, 2000) |
| "Previously, we reported a fatal case of toxic epidermal necrolysis with hyperbilirubinemia, and more than 60% of body surface areas had been eroded for 9 weeks." | 1.36 | Toxic epidermal necrolysis with severe hyperbilirubinemia: complete re-epithelialization after bilirubin reduction therapies. ( Hirasawa, H; Kamada, N; Matsuda, K; Matsue, H; Oda, S; Shinkai, H; Suehiro, K; Togawa, Y; Yokota, M; Yoneyama, K, 2010) |
| "Free bilirubin was not significantly changed by 50 mg/kg VPA-Na, but did show a significant transient elevation with the 200 mg/kg dose." | 1.30 | Effect of valproate on the pharmacokinetics of free and total plasma bilirubin in experimental hyperbilirubinemia in guinea pigs. ( Shen, YZ; Yu, HY, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tukey, RH | 1 |
| Strassburg, CP | 1 |
| Kamada, N | 1 |
| Yoneyama, K | 1 |
| Togawa, Y | 1 |
| Suehiro, K | 1 |
| Shinkai, H | 1 |
| Yokota, M | 1 |
| Matsuda, K | 1 |
| Oda, S | 1 |
| Hirasawa, H | 1 |
| Matsue, H | 1 |
| Yu, HY | 1 |
| Shen, YZ | 1 |
1 review available for valproic acid and Bilirubinemia
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; | 2000 |
2 other studies available for valproic acid and Bilirubinemia
| Article | Year |
|---|---|
Toxic epidermal necrolysis with severe hyperbilirubinemia: complete re-epithelialization after bilirubin reduction therapies.
Topics: Aged; Anticonvulsants; Fatal Outcome; Female; Humans; Hyperbilirubinemia; Plasma Exchange; Sorption | 2010 |
Effect of valproate on the pharmacokinetics of free and total plasma bilirubin in experimental hyperbilirubinemia in guinea pigs.
Topics: Animals; Anticonvulsants; Bilirubin; Binding, Competitive; Blood Proteins; Guinea Pigs; Hyperbilirub | 1998 |