valproic acid has been researched along with Bewilderment in 26 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This is the first report of mixed respiratory alkalosis and metabolic acidosis in a child treated with sulthiame." | 7.76 | Respiratory alkalosis and metabolic acidosis in a child treated with sulthiame. ( Garty, BZ; Hoffer, V; Scheuerman, O; Tirosh, I; Weissbach, A, 2010) |
| "This is the first report of mixed respiratory alkalosis and metabolic acidosis in a child treated with sulthiame." | 3.76 | Respiratory alkalosis and metabolic acidosis in a child treated with sulthiame. ( Garty, BZ; Hoffer, V; Scheuerman, O; Tirosh, I; Weissbach, A, 2010) |
| "Reversible neurotoxic symptoms were observed in three adult patients with absence status epilepticus on lamotrigine (LTG) therapy after administration of an IV bolus followed by oral valproic acid (VPA)." | 3.72 | Neurotoxicity following addition of intravenous valproate to lamotrigine therapy. ( Burneo, JG; Faught, E; Knowlton, RC; Kuzniecky, RI; Lawn, N; Limdi, N; Mendez, M; Prasad, A; Welty, TE, 2003) |
| "This report describes four geriatric patients, with rapid cycling bipolar disorder, who were treated successfully with divalproex sodium in combination with lithium carbonate, noting that both drugs were necessary for clinical remission of symptoms." | 3.70 | Divalproate augmentation in lithium-resistant rapid cycling mania in four geriatric patients. ( Schneider, AL; Wilcox, CS, 1998) |
| "Hyperammonemic encephalopathy is a rare and serious adverse reaction to valproate." | 1.56 | Valproate-induced hyperammonemic encephalopathy: a case report. ( Shah, S; Vieux, U; Wang, R, 2020) |
| "This case report describes a case of influenza B-related meningoencephalitis supported by evidence of an influenza B infection and temporal relation of the neurological event and respiratory illness in the absence of other identifiable cause." | 1.48 | Influenza B-related meningoencephalitis in adults. ( Norton, G; Vallat, W; Yong, CH, 2018) |
| "Subacute encephalopathy with seizures in chronic alcoholism (SESA) was first described in 1981 by Niedermeyer who reported alcoholic patients presenting with confusion, seizures and focal neurological deficits and is quite distinct from patients presenting with typical alcohol withdrawal seizures." | 1.37 | Subacute encephalopathy and seizures in alcoholics (SESA) presenting with non-convulsive status epilepticus. ( LaRoche, SM; Shivdat-Nanhoe, R, 2011) |
| "272 cases of confusion were reported with valproic acid: 153 women and 119 men." | 1.35 | Confusion, a rather serious adverse drug reaction with valproic acid: a review of the French Pharmacovigilance database. ( Bondon-Guitton, E; Montastruc, JL; Sommet, A, 2009) |
| " They have been controlled after increasing her dosage to 600mg/day." | 1.34 | The efficacy of sodium valproate and a MRA finding in confusional migraine. ( Fujita, M; Fujiwara, J; Maki, T; Shibasaki, K; Shigeta, M; Takahashi, M; Takahashi, N, 2007) |
| "Valproic acid-associated hyperammonemic encephalopathy (VHE) has been described in the neurology and emergency medicine literature, but the case reports identified therein are rarely derived from the psychiatric use of this medication." | 1.33 | Valproic acid-associated hyperammonemic encephalopathy: a case report from the psychiatric setting. ( Irwin, SA; Kimmel, RJ; Meyer, JM, 2005) |
| "an elderly patient presented with acute confusion and was found to have nonconvulsive status epilepticus." | 1.31 | Nonconvulsive status epilepticus causing acute confusion. ( Mitchell, SC; Pollock, LM, 2000) |
| "One patient had moderate confusion, and the other mild confusion and hypomania." | 1.30 | Combined valproate or carbamazepine and electroconvulsive therapy. ( Baraibar, G; Tohen, M; Zarate, CA, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (23.08) | 18.7374 |
| 1990's | 6 (23.08) | 18.2507 |
| 2000's | 8 (30.77) | 29.6817 |
| 2010's | 5 (19.23) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Shah, S | 1 |
| Wang, R | 1 |
| Vieux, U | 1 |
| Yong, CH | 1 |
| Vallat, W | 1 |
| Norton, G | 1 |
| Budhdeo, S | 1 |
| Marquette, M | 1 |
| Singh, D | 1 |
| Rajagopal, V | 1 |
| Jackson, R | 1 |
| Toubia, N | 1 |
| Dhaliwal, G | 1 |
| Bottomley, SS | 1 |
| Bronze, MS | 1 |
| Bondon-Guitton, E | 1 |
| Sommet, A | 1 |
| Montastruc, JL | 1 |
| Weissbach, A | 1 |
| Tirosh, I | 1 |
| Scheuerman, O | 1 |
| Hoffer, V | 1 |
| Garty, BZ | 1 |
| LaRoche, SM | 1 |
| Shivdat-Nanhoe, R | 1 |
| Pittermann, P | 1 |
| Gabriel, S | 1 |
| Röschke, J | 1 |
| Burneo, JG | 1 |
| Limdi, N | 1 |
| Kuzniecky, RI | 1 |
| Knowlton, RC | 1 |
| Mendez, M | 1 |
| Lawn, N | 1 |
| Faught, E | 1 |
| Welty, TE | 1 |
| Prasad, A | 1 |
| Kimmel, RJ | 1 |
| Irwin, SA | 1 |
| Meyer, JM | 1 |
| Junig, JT | 1 |
| Lehrmann, JA | 1 |
| Uthamalingam, S | 1 |
| Kumar, S | 1 |
| Vasudevan, AR | 1 |
| Winters, WG | 1 |
| Fujita, M | 1 |
| Fujiwara, J | 1 |
| Maki, T | 1 |
| Shigeta, M | 1 |
| Shibasaki, K | 1 |
| Takahashi, N | 1 |
| Takahashi, M | 1 |
| Somerville, ER | 1 |
| Bruni, J | 1 |
| Costello, LE | 1 |
| Suppes, T | 1 |
| Visticot, F | 1 |
| Montreuil, G | 1 |
| Zarate, CA | 1 |
| Tohen, M | 1 |
| Baraibar, G | 1 |
| Schneider, AL | 1 |
| Wilcox, CS | 1 |
| Ellaway, CJ | 1 |
| Bennetts, B | 1 |
| Tuck, RR | 1 |
| Wilcken, B | 1 |
| Pollock, LM | 1 |
| Mitchell, SC | 1 |
| Lhermitte, F | 1 |
| Marteau, R | 1 |
| Serdaru, M | 1 |
| Boyd, O | 1 |
| Whittingham, F | 1 |
| Clements, D | 1 |
| Rhodes, J | 1 |
| Lanska, DJ | 1 |
| Osorio, I | 1 |
| Tartara, A | 1 |
| Manni, R | 1 |
| Wason, S | 1 |
| Savitt, D | 1 |
| Larrieu, JL | 1 |
| Lagueny, A | 1 |
| Julien, J | 1 |
26 other studies available for valproic acid and Bewilderment
| Article | Year |
|---|---|
Valproate-induced hyperammonemic encephalopathy: a case report.
Topics: Antimanic Agents; Brain Diseases; Confusion; Female; Gait Ataxia; Humans; Hyperammonemia; Middle Age | 2020 |
Influenza B-related meningoencephalitis in adults.
Topics: Aged, 80 and over; Antiviral Agents; Betainfluenzavirus; Confusion; Humans; Influenza, Human; Leveti | 2018 |
Normoammonemic encephalopathy: solely valproate induced or multiple mechanisms?
Topics: Aged; Aggression; Anti-N-Methyl-D-Aspartate Receptor Encephalitis; Brain Diseases; Confusion; Delusi | 2014 |
A confusing case of confusion. Acute porphyrias.
Topics: Acidosis, Lactic; Acute Disease; Anticonvulsants; Brain; Confusion; Diagnosis, Differential; Diet, R | 2008 |
Confusion, a rather serious adverse drug reaction with valproic acid: a review of the French Pharmacovigilance database.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Age Factors; Aged; Aged, 80 and over; Ch | 2009 |
Respiratory alkalosis and metabolic acidosis in a child treated with sulthiame.
Topics: Acid-Base Equilibrium; Acidosis; Alkalosis; Anticonvulsants; Carbamazepine; Child; Confusion; Dose-R | 2010 |
Subacute encephalopathy and seizures in alcoholics (SESA) presenting with non-convulsive status epilepticus.
Topics: Acetamides; Alcohol Withdrawal Seizures; Alcoholism; Anticonvulsants; Brain Diseases; Confusion; Dif | 2011 |
[Delirium caused by nonconvulsive status epilepticus].
Topics: Affect; Aged; Anticonvulsants; Antipsychotic Agents; Brain Edema; Confusion; Delirium; Dibenzothiaze | 2012 |
Neurotoxicity following addition of intravenous valproate to lamotrigine therapy.
Topics: Administration, Oral; Adult; Ammonia; Anticonvulsants; Confusion; Drug Interactions; Drug Therapy, C | 2003 |
Valproic acid-associated hyperammonemic encephalopathy: a case report from the psychiatric setting.
Topics: Antimanic Agents; Bipolar Disorder; Brain Diseases; Confusion; Female; Humans; Hyperammonemia; Middl | 2005 |
A psychotic episode associated with the Atkins diet in a patient with bipolar disorder.
Topics: Antimanic Agents; Anxiety; Bipolar Disorder; Confusion; Diet Fads; Humans; Ketosis; Male; Middle Age | 2005 |
Drowsiness and disorientation in a woman with depression.
Topics: Antimanic Agents; Confusion; Depression; Female; Humans; Middle Aged; Sleep Stages; Valproic Acid | 2005 |
The efficacy of sodium valproate and a MRA finding in confusional migraine.
Topics: Anticonvulsants; Child; Confusion; Electroencephalography; Female; Humans; Magnetic Resonance Angiog | 2007 |
Tonic status epilepticus presenting as confusional state.
Topics: Adolescent; Cognition Disorders; Confusion; Diazepam; Electroencephalography; Humans; Male; Methylph | 1983 |
A clinically significant interaction between clozapine and valproate.
Topics: Adult; Arousal; Bipolar Disorder; Clozapine; Confusion; Dose-Response Relationship, Drug; Drug Inter | 1995 |
[Stupor encephalopathy caused by sodium valproate].
Topics: Coma; Confusion; Female; Humans; Middle Aged; Valproic Acid | 1994 |
Combined valproate or carbamazepine and electroconvulsive therapy.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Carbamazepine; | 1997 |
Divalproate augmentation in lithium-resistant rapid cycling mania in four geriatric patients.
Topics: Age Factors; Aged; Aged, 80 and over; Bipolar Disorder; Confusion; Drug Administration Schedule; Dru | 1998 |
Clumsiness, confusion, coma, and valproate.
Topics: Adult; Coma; Confusion; Fatal Outcome; GABA Agents; Humans; Machado-Joseph Disease; Male; Valproic A | 1999 |
Nonconvulsive status epilepticus causing acute confusion.
Topics: Acute Disease; Aged; Anticonvulsants; Confusion; Diazepam; Epilepsy, Generalized; Fatal Outcome; Fem | 2000 |
[Dipropylacetate (sodium valproate) and carbamazepine : a suspicious anticonvulsant combination].
Topics: Carbamazepine; Cognition Disorders; Confusion; Drug Therapy, Combination; Epilepsy; Humans; Male; Mi | 1978 |
Petit mal status: an unusual cause of confusion.
Topics: Cognition Disorders; Confusion; Electroencephalography; Epilepsy, Absence; Humans; Male; Middle Aged | 1990 |
Valproic acid loading during intensive monitoring.
Topics: Adult; Cognition Disorders; Confusion; Female; Humans; Valproic Acid | 1988 |
Sodium valproate "encephalopathy": report of three cases with generalised epilepsy.
Topics: Adult; Arousal; Brain Diseases; Child; Confusion; Electroencephalography; Epilepsy; Female; Humans; | 1985 |
Acute valproic acid toxicity at therapeutic concentrations.
Topics: Child; Cognition Disorders; Confusion; Female; Humans; Substance-Related Disorders; Valproic Acid | 1985 |
[State of confusion induced by valproic acid and reversed after administration of clonazepam].
Topics: Adult; Benzodiazepinones; Clonazepam; Cognition Disorders; Confusion; Drug Therapy, Combination; Ele | 1985 |