valproic acid has been researched along with Benign Cerebellar Neoplasms in 8 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Histone deacetylate inhibitors (HDACi), as valproic acid (VA), have been reported to enhance efficacy and to prevent drug resistance in some tumors, including medulloblastoma (MB)." | 7.88 | Valproic acid treatment response in vitro is determined by TP53 status in medulloblastoma. ( Cavalheiro, S; Dastoli, P; Mascaro-Cordeiro, B; Oliveira, ID; Pavon, LF; Saba-Silva, N; Tesser-Gamba, F; Toledo, SRC, 2018) |
| "To develop novel orthotopic xenograft models of medulloblastoma in severe combined immunodeficient mice and to evaluate the in vivo antitumor efficacy of valproic acid." | 7.73 | Valproic Acid prolongs survival time of severe combined immunodeficient mice bearing intracerebellar orthotopic medulloblastoma xenografts. ( Adesina, A; Antalffy, B; Blaney, SM; Lau, CC; Li, XN; Ou, CN; Pietsch, T; Shu, Q; Su, JM, 2006) |
| "Histone deacetylate inhibitors (HDACi), as valproic acid (VA), have been reported to enhance efficacy and to prevent drug resistance in some tumors, including medulloblastoma (MB)." | 3.88 | Valproic acid treatment response in vitro is determined by TP53 status in medulloblastoma. ( Cavalheiro, S; Dastoli, P; Mascaro-Cordeiro, B; Oliveira, ID; Pavon, LF; Saba-Silva, N; Tesser-Gamba, F; Toledo, SRC, 2018) |
| "To develop novel orthotopic xenograft models of medulloblastoma in severe combined immunodeficient mice and to evaluate the in vivo antitumor efficacy of valproic acid." | 3.73 | Valproic Acid prolongs survival time of severe combined immunodeficient mice bearing intracerebellar orthotopic medulloblastoma xenografts. ( Adesina, A; Antalffy, B; Blaney, SM; Lau, CC; Li, XN; Ou, CN; Pietsch, T; Shu, Q; Su, JM, 2006) |
| "Medulloblastoma is the most common malignant brain tumor in children." | 1.43 | Successful Use of Dose Dense Neoadjuvant Chemotherapy and Sodium Valproate with Minimal Toxicity in an Infant with Medulloblastoma in Extremely Poor General Condition. ( Abrari, A; Gupta, A; Kumar, A; Patir, R; Vaishya, S, 2016) |
| "Headache is a significant problem with the suboccipital approach for acoustic tumor removal." | 1.30 | Medical treatment of headache after suboccipital acoustic tumor removal. ( Brandes, JL; Glasscock, ME; Hanson, MB; Jackson, CG, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mascaro-Cordeiro, B | 1 |
| Oliveira, ID | 1 |
| Tesser-Gamba, F | 1 |
| Pavon, LF | 1 |
| Saba-Silva, N | 1 |
| Cavalheiro, S | 1 |
| Dastoli, P | 1 |
| Toledo, SRC | 1 |
| Patties, I | 2 |
| Kortmann, RD | 2 |
| Glasow, A | 2 |
| Menzel, F | 1 |
| Gupta, A | 1 |
| Kumar, A | 1 |
| Abrari, A | 1 |
| Patir, R | 1 |
| Vaishya, S | 1 |
| Häcker, S | 1 |
| Dittrich, A | 1 |
| Mohr, A | 1 |
| Schweitzer, T | 1 |
| Rutkowski, S | 1 |
| Krauss, J | 1 |
| Debatin, KM | 1 |
| Fulda, S | 1 |
| Shu, Q | 1 |
| Antalffy, B | 1 |
| Su, JM | 1 |
| Adesina, A | 1 |
| Ou, CN | 1 |
| Pietsch, T | 1 |
| Blaney, SM | 1 |
| Lau, CC | 1 |
| Li, XN | 1 |
| Kulkarni, S | 1 |
| Hegde, A | 1 |
| Shah, KN | 1 |
| Hanson, MB | 1 |
| Glasscock, ME | 1 |
| Brandes, JL | 1 |
| Jackson, CG | 1 |
8 other studies available for valproic acid and Benign Cerebellar Neoplasms
| Article | Year |
|---|---|
Valproic acid treatment response in vitro is determined by TP53 status in medulloblastoma.
Topics: Cell Line, Tumor; Cell Survival; Cerebellar Neoplasms; Dose-Response Relationship, Drug; Genetic Var | 2018 |
Inhibitory effects of epigenetic modulators and differentiation inducers on human medulloblastoma cell lines.
Topics: Antineoplastic Agents; Azacitidine; Cell Line, Tumor; Cell Proliferation; Cerebellar Neoplasms; Deci | 2013 |
Enhanced inhibition of clonogenic survival of human medulloblastoma cells by multimodal treatment with ionizing irradiation, epigenetic modifiers, and differentiation-inducing drugs.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cell Di | 2016 |
Successful Use of Dose Dense Neoadjuvant Chemotherapy and Sodium Valproate with Minimal Toxicity in an Infant with Medulloblastoma in Extremely Poor General Condition.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cerebellar Neoplasms; Child; Child, Pre | 2016 |
Histone deacetylase inhibitors cooperate with IFN-gamma to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8.
Topics: Benzamides; Caspase 8; Cell Line, Tumor; Cell Survival; Cerebellar Neoplasms; Drug Combinations; Dru | 2009 |
Valproic Acid prolongs survival time of severe combined immunodeficient mice bearing intracerebellar orthotopic medulloblastoma xenografts.
Topics: Animals; Carcinogenicity Tests; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cell Sur | 2006 |
Hemifacial seizures and cerebellar tumor: a rare co-existence.
Topics: Anticonvulsants; Benzodiazepines; Cerebellar Neoplasms; Child, Preschool; Clobazam; Comorbidity; Gan | 2007 |
Medical treatment of headache after suboccipital acoustic tumor removal.
Topics: Adult; Cerebellar Neoplasms; Cerebellopontine Angle; Craniotomy; Drug Therapy, Combination; Female; | 1998 |