valproic acid has been researched along with Becker Muscular Dystrophy in 2 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Valproic acid (VPA) was found to enhance alpha7 integrin levels, induce muscle hypertrophy, and inhibit apoptosis in myotubes by activating the Akt/mTOR/p70S6K pathway." | 3.75 | Valproic acid activates the PI3K/Akt/mTOR pathway in muscle and ameliorates pathology in a mouse model of Duchenne muscular dystrophy. ( Burkin, DJ; Gurpur, PB; Kaufman, SJ; Liu, J, 2009) |
| "Skeletal muscles in animal models of Duchenne muscular dystrophy (DMD) are more susceptible to contraction-induced functional loss, which is not related to fatigue." | 1.91 | Valproic acid reduces muscle susceptibility to contraction-induced functional loss but increases weakness in two murine models of Duchenne muscular dystrophy. ( Agbulut, O; Delacroix, C; Ferry, A; Furling, D; Lemaitre, M; Moutachi, D, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moutachi, D | 1 |
| Lemaitre, M | 1 |
| Delacroix, C | 1 |
| Agbulut, O | 1 |
| Furling, D | 1 |
| Ferry, A | 1 |
| Gurpur, PB | 1 |
| Liu, J | 1 |
| Burkin, DJ | 1 |
| Kaufman, SJ | 1 |
2 other studies available for valproic acid and Becker Muscular Dystrophy
| Article | Year |
|---|---|
Valproic acid reduces muscle susceptibility to contraction-induced functional loss but increases weakness in two murine models of Duchenne muscular dystrophy.
Topics: Animals; Desmin; Disease Models, Animal; Female; Mice; Mice, Inbred mdx; Muscle Contraction; Muscle, | 2023 |
Valproic acid activates the PI3K/Akt/mTOR pathway in muscle and ameliorates pathology in a mouse model of Duchenne muscular dystrophy.
Topics: Animals; beta-Galactosidase; Carrier Proteins; Cell Culture Techniques; Disease Models, Animal; Enzy | 2009 |