valproic acid has been researched along with B-Cell Chronic Lymphocytic Leukemia in 8 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 3 (37.50) | 2.80 |
| Authors | Studies |
|---|---|
| Wen, J | 1 |
| Chen, Y | 1 |
| Yang, J | 1 |
| Dai, C | 1 |
| Yu, S | 1 |
| Zhong, W | 1 |
| Liu, L | 2 |
| He, C | 1 |
| Zhang, W | 1 |
| Yang, T | 1 |
| Hu, J | 1 |
| Lipska, K | 2 |
| Filip, A | 1 |
| Gumieniczek, A | 2 |
| Pietraś, R | 1 |
| Filip, AA | 1 |
| Scialdone, A | 1 |
| Hasni, MS | 1 |
| Damm, JK | 1 |
| Lennartsson, A | 1 |
| Gullberg, U | 1 |
| Drott, K | 1 |
| Yoon, JY | 1 |
| Ishdorj, G | 1 |
| Graham, BA | 1 |
| Johnston, JB | 1 |
| Gibson, SB | 1 |
| Bouzar, AB | 1 |
| Boxus, M | 1 |
| Defoiche, J | 1 |
| Berchem, G | 1 |
| Macallan, D | 1 |
| Pettengell, R | 1 |
| Willis, F | 1 |
| Burny, A | 1 |
| Lagneaux, L | 3 |
| Bron, D | 3 |
| Chatelain, B | 1 |
| Chatelain, C | 1 |
| Willems, L | 2 |
| Stamatopoulos, B | 2 |
| Meuleman, N | 2 |
| De Bruyn, C | 1 |
| Mineur, P | 1 |
| Martiat, P | 2 |
| Gillet, N | 1 |
| Delforge, A | 1 |
| Dejeneffe, M | 1 |
| Massy, M | 1 |
| Kentos, A | 1 |
8 other studies available for valproic acid and B-Cell Chronic Lymphocytic Leukemia
| Article | Year |
|---|---|
Valproic acid increases CAR T cell cytotoxicity against acute myeloid leukemia.
Topics: Animals; Cell Line, Tumor; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Mice; N | 2023 |
The Impact of Chlorambucil and Valproic Acid on Cell Viability, Apoptosis and Expression of
Topics: Aged; Aged, 80 and over; Apoptosis; Cell Survival; Chlorambucil; Cyclin-Dependent Kinase Inhibitor p | 2021 |
HPLC-UV and GC-MS Methods for Determination of Chlorambucil and Valproic Acid in Plasma for Further Exploring a New Combined Therapy of Chronic Lymphocytic Leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Calibration; Chlorambucil; Chromatography, High Pres | 2021 |
The HDAC inhibitor valproate induces a bivalent status of the CD20 promoter in CLL patients suggesting distinct epigenetic regulation of CD20 expression in CLL in vivo.
Topics: Aged; Antigens, CD20; B-Lymphocytes; Cell Line, Tumor; Enhancer of Zeste Homolog 2 Protein; Epigenes | 2017 |
Valproic acid enhances fludarabine-induced apoptosis mediated by ROS and involving decreased AKT and ATM activation in B-cell-lymphoid neoplastic cells.
Topics: Adult; Antineoplastic Agents; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Drug Synergism; Enz | 2014 |
Valproate synergizes with purine nucleoside analogues to induce apoptosis of B-chronic lymphocytic leukaemia cells.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Apoptosis; Blotting, Western; Cladribine; Dru | 2009 |
Antileukemic activity of valproic acid in chronic lymphocytic leukemia B cells defined by microarray analysis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Cell Proli | 2009 |
Valproic acid induces apoptosis in chronic lymphocytic leukemia cells through activation of the death receptor pathway and potentiates TRAIL response.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Apoptosis; B-Lymphocytes; CASP8 and FADD-Like Apoptosis Re | 2007 |