valproic acid has been researched along with Autosomal Dominant Striatonigral Degeneration in 6 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In spite of limited results, the use of another dosage of VPA or of VPA in a combined therapy with molecules targeting other pathways, cannot be excluded as potential strategies for MJD therapeutics." | 5.42 | Limited Effect of Chronic Valproic Acid Treatment in a Mouse Model of Machado-Joseph Disease. ( Duarte-Silva, S; Esteves, S; Maciel, P; Naia, L; Neves-Carvalho, A; Rego, AC; Silva-Fernandes, A; Teixeira-Castro, A, 2015) |
| "Valproic acid (VPA) is a pan-HDAC inhibitor used clinically to treat bipolar and seizure disorders." | 2.82 | Safety and efficacy of valproic acid treatment in SCA3/MJD patients. ( Chuang, DM; Jiang, H; Lei, LF; Song, WH; Tang, BS; Wang, JL; Yang, GP, 2016) |
| "Machado-Joseph disease (MJD, also known as spinocerebellar ataxia type 3) is a fatal neurodegenerative disease that impairs control and coordination of movement." | 1.62 | Sodium valproate increases activity of the sirtuin pathway resulting in beneficial effects for spinocerebellar ataxia-3 in vivo. ( Chung, RS; Cole, NJ; De Luca, A; Guillemin, GJ; Laird, AS; Lee, A; Luu, L; Nicholson, GA; Robinson, KJ; Suddull, HJ; Tym, MC; Watchon, M; Yuan, KC, 2021) |
| " In spite of limited results, the use of another dosage of VPA or of VPA in a combined therapy with molecules targeting other pathways, cannot be excluded as potential strategies for MJD therapeutics." | 1.42 | Limited Effect of Chronic Valproic Acid Treatment in a Mouse Model of Machado-Joseph Disease. ( Duarte-Silva, S; Esteves, S; Maciel, P; Naia, L; Neves-Carvalho, A; Rego, AC; Silva-Fernandes, A; Teixeira-Castro, A, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Watchon, M | 1 |
| Luu, L | 1 |
| Robinson, KJ | 1 |
| Yuan, KC | 1 |
| De Luca, A | 1 |
| Suddull, HJ | 1 |
| Tym, MC | 1 |
| Guillemin, GJ | 1 |
| Cole, NJ | 1 |
| Nicholson, GA | 1 |
| Chung, RS | 1 |
| Lee, A | 1 |
| Laird, AS | 1 |
| Wang, Z | 1 |
| He, F | 1 |
| Abeditashi, M | 1 |
| Schmidt, T | 1 |
| Esteves, S | 1 |
| Duarte-Silva, S | 1 |
| Naia, L | 1 |
| Neves-Carvalho, A | 1 |
| Teixeira-Castro, A | 1 |
| Rego, AC | 1 |
| Silva-Fernandes, A | 1 |
| Maciel, P | 1 |
| Lei, LF | 1 |
| Yang, GP | 1 |
| Wang, JL | 1 |
| Chuang, DM | 1 |
| Song, WH | 1 |
| Tang, BS | 1 |
| Jiang, H | 2 |
| Yi, J | 1 |
| Zhang, L | 1 |
| Tang, B | 1 |
| Han, W | 1 |
| Zhou, Y | 1 |
| Chen, Z | 1 |
| Jia, D | 1 |
| Ellaway, CJ | 1 |
| Bennetts, B | 1 |
| Tuck, RR | 1 |
| Wilcken, B | 1 |
1 trial available for valproic acid and Autosomal Dominant Striatonigral Degeneration
| Article | Year |
|---|---|
Safety and efficacy of valproic acid treatment in SCA3/MJD patients.
Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Enzyme Inhibitors; Female; Histone Dea | 2016 |
5 other studies available for valproic acid and Autosomal Dominant Striatonigral Degeneration
| Article | Year |
|---|---|
Sodium valproate increases activity of the sirtuin pathway resulting in beneficial effects for spinocerebellar ataxia-3 in vivo.
Topics: Acetylation; Animals; Animals, Genetically Modified; Ataxin-3; Autophagy; Carbazoles; Disease Models | 2021 |
Divalproex sodium regulates ataxin-3 translocation likely by an importin α1-dependent pathway.
Topics: alpha Karyopherins; Animals; Ataxin-3; Cell Nucleus; CHO Cells; Cricetulus; Gene Expression; HEK293 | 2019 |
Limited Effect of Chronic Valproic Acid Treatment in a Mouse Model of Machado-Joseph Disease.
Topics: Animals; Astrocytes; Ataxin-3; Brain; Disease Models, Animal; Endoplasmic Reticulum Chaperone BiP; H | 2015 |
Sodium valproate alleviates neurodegeneration in SCA3/MJD via suppressing apoptosis and rescuing the hypoacetylation levels of histone H3 and H4.
Topics: Acetylation; Animals; Animals, Genetically Modified; Apoptosis; Cells, Cultured; DNA Repeat Expansio | 2013 |
Clumsiness, confusion, coma, and valproate.
Topics: Adult; Coma; Confusion; Fatal Outcome; GABA Agents; Humans; Machado-Joseph Disease; Male; Valproic A | 1999 |