valproic acid has been researched along with Autism Spectrum Disorder in 219 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Autism Spectrum Disorder: Wide continuum of associated cognitive and neurobehavioral disorders, including, but not limited to, three core-defining features: impairments in socialization, impairments in verbal and nonverbal communication, and restricted and repetitive patterns of behaviors. (from DSM-V)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid (VPA) induced rodent model of autism is a widely accepted and extensively used rodent model to investigate the pharmacotherapy against autism." | 9.22 | Critical Evaluation of Valproic Acid-Induced Rodent Models of Autism: Current and Future Perspectives. ( Chopra, M; Mehra, S; Seth, E; Ul Ahsan, A, 2022) |
| " Previously, we have established a mouse model of ASD based on clinical research, which shows that exposure to valproic acid, an antiepileptic drug, during pregnancy causes an increase in the risk of developing ASD in children." | 9.01 | [Chronic Activation of the Dopaminergic Neuronal Pathway Improves Behavioral Abnormalities in the Prenatal Valproic Acid Exposure Mouse Model of Autism Spectrum Disorder]. ( Hara, Y, 2019) |
| "Autism spectrum disorders are complex behavioral disorders that can be caused by exposure to valproic acid (VPA) during pregnancy." | 8.31 | Effects of varied‑intensity endurance exercise training on oxidative and antioxidant factors in the liver of rats with valproic acid‑induced autism. ( Aminzadeh, A; Bashiri, H; Heidari, M; Mirzavandi, F; Moslemizadeh, A; Parizi, AS; Pouya, F; Sabet, N, 2023) |
| "Risperidone is the first antipsychotic to be approved by Food and Drug Administration (FDA) for treating autism spectrum disorder (ASD)." | 8.31 | The comparative effectiveness of metformin and risperidone in a rat model of valproic acid-induced autism, Potential role for enhanced autophagy. ( Ashour, RH; Atia, AA; Rahman, KM; Ramadan, NM; Zaki, MM, 2023) |
| " VPA-exposed male pups were administered with two doses of ibudilast (5 and10 mg/kg) and all the groups were evaluated for behavioral parameters like social interaction, spatial memory/learning, anxiety, locomotor activity, and nociceptive threshold." | 8.31 | Phosphodiesterase inhibitor, ibudilast alleviates core behavioral and biochemical deficits in the prenatal valproic acid exposure model of autism spectrum disorder. ( Gautam, V; Kumar, A; Rawat, K; Saha, L; Sandhu, A; Sharma, A, 2023) |
| " Valproic acid (VPA) exposure during pregnancy causes autistic-like traits in offspring." | 8.31 | The antipsychotic olanzapine reduces memory deficits and neuronal abnormalities in a male rat model of Autism. ( Aguilar-Hernandez, L; Bringas, ME; Flores, G; Garcés-Ramírez, L; Lima-Castañeda, LÁ; Morales-Medina, JC, 2023) |
| "Prenatal exposure to valproic acid (VPA) may enhance the risk of autism spectrum disorder (ASD) in children." | 8.31 | Prangos ferulacea (L.) ameliorates behavioral alterations, hippocampal oxidative stress markers, and apoptotic deficits in a rat model of autism induced by valproic acid. ( Aldaghi, MR; Raise-Abdullahi, P; Saadat, M; Sameni, HR; Taherian, AA; Vafaei, AA, 2023) |
| " Therefore, in this study, we focused on the rapid and persistent neuroprotective function of DLX following valproic acid (VPA)-triggered hyperactivity, anxiety-like behavior and social deficits in zebrafish." | 8.12 | Duloxetine ameliorates valproic acid-induced hyperactivity, anxiety-like behavior, and social interaction deficits in zebrafish. ( Chen, H; Joseph, TP; Lin, SL; Sai, LY; Schachner, M; Zhou, F, 2022) |
| "Valproic acid (VPA) exposure as an environmental factor that confers risk of autism spectrum disorder (ASD), its functional mechanisms in the human brain remain unclear since relevant studies are currently restricted to two-dimensional cell cultures and animal models." | 8.12 | Human forebrain organoids reveal connections between valproic acid exposure and autism risk. ( Chen, C; Jiao, C; Liu, C; Meng, Q; Tang, B; Wang, X; Xu, S; Zhang, W, 2022) |
| "We previously demonstrated that prenatal exposure to valproic acid (VPA), an environmental model of autism spectrum disorder (ASD), leads to a hyperexcitable phenotype associated with downregulation of inward-rectifying potassium currents in nucleus accumbens (NAc) medium spiny neurons (MSNs) of adolescent rats." | 8.12 | Acute rapamycin rescues the hyperexcitable phenotype of accumbal medium spiny neurons in the valproic acid rat model of autism spectrum disorder. ( Costa, A; Curti, L; D'Ambrosio, M; Gerace, E; Iezzi, D; Ilari, A; La Rocca, A; Luceri, C; Mannaioni, G; Masi, A; Ranieri, G; Scardigli, M; Silvestri, L, 2022) |
| "Prenatal exposure to valproic acid (VPA) has been implicated in the manifestation of autism spectrum disorder (ASD)-like behavioral and functional changes both in human and rodents including mice and rats." | 8.12 | Metabolomics profiling of valproic acid-induced symptoms resembling autism spectrum disorders using 1H NMR spectral analysis in rat model. ( Kim, HY; Kim, JW; Kim, KB; Kim, S; Kim, SJ; Ko, MJ; Lee, JD; Lee, YJ; Shin, CY, 2022) |
| "The cilostazol regimen, attenuated prenatal VPA exposure associated hyperlocomotion, social interaction deficits, repetitive behavior, and anxiety." | 8.02 | Cilostazol attenuated prenatal valproic acid-induced behavioural and biochemical deficits in a rat model of autism spectrum disorder. ( Kulkarni, GT; Luhach, K; Sharma, B; Singh, VP, 2021) |
| "In this study, we performed 16S rRNA gene sequencing and untargeted metabolomics in parallel on fecal samples from a valproic acid (VPA)-induced rat model of autism (VPA rats)." | 8.02 | Sex-specific differences in the gut microbiota and fecal metabolites in an adolescent valproic acid-induced rat autism model. ( Cui, YN; Gu, YY; Han, Y; Liang, JJ; Qin, J; Zhang, B; Zhang, SB; Zhang, Y, 2021) |
| " This study examined the effect of metformin on VPA-induced autism spectrum disorders in rats." | 7.96 | Novel potential of metformin on valproic acid-induced autism spectrum disorder in rats: involvement of antioxidant defence system. ( Adeyemi, OO; Balogun, AO; Ishola, IO, 2020) |
| " Valproic acid (VPA) is an anticonvulsant drug in both human and rodents with teratogenic effects during pregnancy." | 7.91 | Benefits of Fenofibrate in prenatal valproic acid-induced autism spectrum disorder related phenotype in rats. ( Mirza, R; Sharma, B, 2019) |
| " Here, we investigate the impact on the corticostriosomal pathway in the valproic acid (VPA)-induced autism spectrum disorder mouse model." | 7.85 | Valproic acid induces aberrant development of striatal compartments and corticostriatal pathways in a mouse model of autism spectrum disorder. ( Kuo, HY; Liu, FC, 2017) |
| "Prenatal exposure to the antiepileptic, mood-stabilizing drug, valproic acid (VPA), increases the incidence of autism spectrum disorders (ASDs); in utero administration of VPA to pregnant rodents induces ASD-like behaviors such as repetitive, stereotyped activity, and decreased socialization." | 7.85 | Sexually Dimorphic Epigenetic Regulation of Brain-Derived Neurotrophic Factor in Fetal Brain in the Valproic Acid Model of Autism Spectrum Disorder. ( Densmore, AL; Konopko, MA; Krueger, BK, 2017) |
| "Valproic acid administration during gestational period causes behavior and biochemical deficits similar to those observed in humans with autism spectrum disorder." | 7.81 | Benefits of agomelatine in behavioral, neurochemical and blood brain barrier alterations in prenatal valproic acid induced autism spectrum disorder. ( Kumar, H; Sharma, B; Sharma, BM, 2015) |
| "Valproic acid (VPA) is an effective drug, which is preferred for the treatments of epilepsy and various kinds of seizures." | 6.44 | The effects of valproic acid neurotoxicity on aggressive behavior in zebrafish autism model. ( Feng, T; Li, X; Lu, W, 2024) |
| "Thymol is a bioactive monoterpene isolated from Thymus vulgaris that has anti-inflammatory properties and is helpful in neurodevelopmental disorders." | 5.91 | Thymol improves autism-like behaviour in VPA-induced ASD rats through the Pin1/p38 MAPK pathway. ( Chen, J; Li, Y; Lv, M; Tang, B; Wang, F; Xiong, Y; Zhang, H, 2023) |
| "Many studies show that the number of cognitive impairmentscan be reduced by antagonists of the histamine H3 receptor (H3R)." | 5.91 | Amelioration of cognition impairments in the valproic acid-induced animal model of autism by ciproxifan, a histamine H3-receptor antagonist. ( Esmaeilpour, K; Sepehri, G; Sheibani, V; Shekari, MA; Taheri, F, 2023) |
| "Valproic acid (VPA) is a well-known anti-epileptic drug, but its prenatal exposure to animals causes social impairment, neurotransmitters imbalance, and neuroinflammation with ASD-like phenotypes." | 5.91 | Syringic acid alleviates valproic acid induced autism via activation of p38 mitogen-activated protein kinase: Possible molecular approach. ( Mallan, S; Singh, S, 2023) |
| "Valproic acid (VPA) is a widely prescribed antiepileptic drug with various medicinal efficacies." | 5.91 | Toxicity and teratogenicity effects of valproic acid on zebrafish (Danio rerio) embryos in relation to autism spectrum disorder. ( Azmai, MNA; Bakar, NA; Chong, SG; Fadzar, MSIM; Fahmi, MSAM; Faudzi, SMM; Hamid, NNAZZ; Ibrahim, WNW; Mastuki, SN; Norazhar, AI; Ramlan, NF; Saleh Hodin, NA; Zulkifli, AR, 2023) |
| "The mouse model of autism induced by prenatal exposure to valproic acid (VPA) was used to assess the therapeutic potential of STX209 on autism‑like behaviour in the present study." | 5.72 | The GABAB receptor agonist STX209 reverses the autism‑like behaviour in an animal model of autism induced by prenatal exposure to valproic acid. ( Chang, H; Ding, J; Gao, C; He, M; Jiang, S; Li, W; Sun, T; Sun, Y; Wang, F; Wang, Y; Xiao, L; Zhu, C, 2022) |
| " Pregnant C57BL/6 J mice were intraperitoneally injected with a dosage of 500 mg/kg valproic acid (VPA) on embryonic day 10." | 5.72 | Size anomaly and alteration of GABAergic enzymes expressions in cerebellum of a valproic acid mouse model of autism. ( Kwan, KM; Ma, SY, 2022) |
| "Autism spectrum disorder is a neurodevelopmental disorder characterized by sensory abnormalities, social skills impairment and cognitive deficits." | 5.72 | Alterations in the intrinsic discharge activity of CA1 pyramidal neurons associated with possible changes in the NADPH diaphorase activity in a rat model of autism induced by prenatal exposure to valproic acid. ( Behzadi, G; Borjkhani, M; Davoudi, S; Hajisoltani, R; Hosseinmardi, N; Janahmadi, M; Karimi, SA; Khatibi, VA; Rahdar, M, 2022) |
| "Previous studies have indicated that autism-like behavioral phenotypes detected in F1 VPA mice transgenetically appear in F2 and F3 generations." | 5.72 | Early-onset of social communication and locomotion activity in F2 pups of a valproic acid-induced mouse model of autism. ( Fu, P; Furuhara, K; Higashida, H; Minami, K; Mizutani, R; Tsuji, C; Tsuji, T; Yokoyama, S; Zhong, J, 2022) |
| "Melatonin is an endogenous hormone and can restore gut microbial dysbiosis under various disease conditions." | 5.72 | Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism. ( Cui, Y; Li, XG; Liu, W; Liu, X; Qiu, B; Wang, X; Xiang, G; Yu, M; Zhang, D; Zhang, Y, 2022) |
| "Previously, autism spectrum disorder (ASD) has been identified mainly by social communication deficits and behavioral symptoms." | 5.42 | Alteration of spontaneous spectral powers and coherences of local field potential in prenatal valproic acid mouse model of autism. ( Cheaha, D; Kumarnsit, E, 2015) |
| "Valproic acid (VPA) induced rodent model of autism is a widely accepted and extensively used rodent model to investigate the pharmacotherapy against autism." | 5.22 | Critical Evaluation of Valproic Acid-Induced Rodent Models of Autism: Current and Future Perspectives. ( Chopra, M; Mehra, S; Seth, E; Ul Ahsan, A, 2022) |
| " Previously, we have established a mouse model of ASD based on clinical research, which shows that exposure to valproic acid, an antiepileptic drug, during pregnancy causes an increase in the risk of developing ASD in children." | 5.01 | [Chronic Activation of the Dopaminergic Neuronal Pathway Improves Behavioral Abnormalities in the Prenatal Valproic Acid Exposure Mouse Model of Autism Spectrum Disorder]. ( Hara, Y, 2019) |
| " In particular, exposure to valproic acid (VPA) during pregnancy has been demonstrated to increase the risk of autism in children." | 4.98 | The valproic acid-induced rodent model of autism. ( Fahnestock, M; Nicolini, C, 2018) |
| "Microglial dysfunction has been reported in the valproic acid (VPA)-induced autism spectrum disorder (ASD) rat models." | 4.31 | Prenatally VPA exposure is likely to cause autistic-like behavior in the rats offspring via TREM2 down-regulation to affect the microglial activation and synapse alterations. ( Chen, J; Hu, C; Li, T; Luo, L; Wei, H; Wu, Q; Yang, T; Yuan, B, 2023) |
| "Autism spectrum disorder is a developmental disorder that can affect sensory-motor behaviors in the valproic acid (Val) rodent model of autism." | 4.31 | Alteration in social interaction and tactile discrimination of juvenile autistic-like rats following tactile stimulation and whisker deprivation. ( Afarinesh, MR; Ahmadi, BBM; Jafaripour, L; Sheibani, V, 2023) |
| "Autism spectrum disorders are complex behavioral disorders that can be caused by exposure to valproic acid (VPA) during pregnancy." | 4.31 | Effects of varied‑intensity endurance exercise training on oxidative and antioxidant factors in the liver of rats with valproic acid‑induced autism. ( Aminzadeh, A; Bashiri, H; Heidari, M; Mirzavandi, F; Moslemizadeh, A; Parizi, AS; Pouya, F; Sabet, N, 2023) |
| "Risperidone is the first antipsychotic to be approved by Food and Drug Administration (FDA) for treating autism spectrum disorder (ASD)." | 4.31 | The comparative effectiveness of metformin and risperidone in a rat model of valproic acid-induced autism, Potential role for enhanced autophagy. ( Ashour, RH; Atia, AA; Rahman, KM; Ramadan, NM; Zaki, MM, 2023) |
| " Valproic acid (VPA) is an anticonvulsant drug that, when administered during pregnancy, causes various birth defects." | 4.31 | Social deficits in mice prenatally exposed to valproic acid are intergenerationally inherited and rescued by social enrichment. ( Barrios, CD; Depino, AM; Zappala, C, 2023) |
| " VPA-exposed male pups were administered with two doses of ibudilast (5 and10 mg/kg) and all the groups were evaluated for behavioral parameters like social interaction, spatial memory/learning, anxiety, locomotor activity, and nociceptive threshold." | 4.31 | Phosphodiesterase inhibitor, ibudilast alleviates core behavioral and biochemical deficits in the prenatal valproic acid exposure model of autism spectrum disorder. ( Gautam, V; Kumar, A; Rawat, K; Saha, L; Sandhu, A; Sharma, A, 2023) |
| "Valproic acid (VPA) treatment during pregnancy is a risk factor for developing autism spectrum disorder, cognitive deficits, and stress-related disorders in children." | 4.31 | Adolescent swimming exercise following maternal valproic acid treatment improves cognition and reduces stress-related symptoms in offspring mice: Role of sex and brain cytokines. ( Amouzad Mahdirejei, H; Barzegari, A; Esmaeili, MH; Hanani, M; Salari, AA, 2023) |
| " Valproic acid (VPA) exposure during pregnancy causes autistic-like traits in offspring." | 4.31 | The antipsychotic olanzapine reduces memory deficits and neuronal abnormalities in a male rat model of Autism. ( Aguilar-Hernandez, L; Bringas, ME; Flores, G; Garcés-Ramírez, L; Lima-Castañeda, LÁ; Morales-Medina, JC, 2023) |
| "Prenatal exposure to valproic acid (VPA) may enhance the risk of autism spectrum disorder (ASD) in children." | 4.31 | Prangos ferulacea (L.) ameliorates behavioral alterations, hippocampal oxidative stress markers, and apoptotic deficits in a rat model of autism induced by valproic acid. ( Aldaghi, MR; Raise-Abdullahi, P; Saadat, M; Sameni, HR; Taherian, AA; Vafaei, AA, 2023) |
| "Autism spectrum disorder (ASD) is a developmental disorder associated with in utero exposure to the antiepileptic valproic acid (VPA) in humans, and similar exposure serves as a validated animal model." | 4.12 | Brainstem motor neuron dysmorphology and excitatory/inhibitory imbalance in an animal model of autism. ( Alhelo, H; Kulesza, RJ, 2022) |
| " Therefore, in this study, we focused on the rapid and persistent neuroprotective function of DLX following valproic acid (VPA)-triggered hyperactivity, anxiety-like behavior and social deficits in zebrafish." | 4.12 | Duloxetine ameliorates valproic acid-induced hyperactivity, anxiety-like behavior, and social interaction deficits in zebrafish. ( Chen, H; Joseph, TP; Lin, SL; Sai, LY; Schachner, M; Zhou, F, 2022) |
| " Valproic acid (VPA) injection during pregnancy elicits autism-like behavior in the offspring, making it a classic animal model of ASD." | 4.12 | iTRAQ-Based Proteomics Analysis of Rat Cerebral Cortex Exposed to Valproic Acid before Delivery. ( Cao, X; Chen, M; Lin, J; Liu, X; Shen, L; Tang, X; Ullah Khan, N; Zhang, H; Zhang, K; Zhao, Y, 2022) |
| "Valproic acid (VPA) exposure as an environmental factor that confers risk of autism spectrum disorder (ASD), its functional mechanisms in the human brain remain unclear since relevant studies are currently restricted to two-dimensional cell cultures and animal models." | 4.12 | Human forebrain organoids reveal connections between valproic acid exposure and autism risk. ( Chen, C; Jiao, C; Liu, C; Meng, Q; Tang, B; Wang, X; Xu, S; Zhang, W, 2022) |
| "Maternal exposure to anti-epileptic drug Valproic acid (VPA) during pregnancy increases the risk for the development of autism spectrum disorders (ASD)." | 4.12 | Prenatal exposure to valproic acid alters Reelin, NGF expressing neuron architecture and impairs social interaction in their autistic-like phenotype male offspring. ( Rajan, KE; Sivasangari, K, 2022) |
| "Valproic acid (VPA) is a clinically used antiepileptic drug, but it is associated with a significant risk of a low verbal intelligence quotient (IQ) score, attention-deficit hyperactivity disorder and autism spectrum disorder in children when it is administered during pregnancy." | 4.12 | A CCR5 antagonist, maraviroc, alleviates neural circuit dysfunction and behavioral disorders induced by prenatal valproate exposure. ( Honda, T; Ishihara, N; Ishihara, Y; Itoh, K; Namba, K; Taketoshi, M; Tominaga, T; Tominaga, Y; Tsuji, M; Vogel, CFA; Yamazaki, T, 2022) |
| "We previously demonstrated that prenatal exposure to valproic acid (VPA), an environmental model of autism spectrum disorder (ASD), leads to a hyperexcitable phenotype associated with downregulation of inward-rectifying potassium currents in nucleus accumbens (NAc) medium spiny neurons (MSNs) of adolescent rats." | 4.12 | Acute rapamycin rescues the hyperexcitable phenotype of accumbal medium spiny neurons in the valproic acid rat model of autism spectrum disorder. ( Costa, A; Curti, L; D'Ambrosio, M; Gerace, E; Iezzi, D; Ilari, A; La Rocca, A; Luceri, C; Mannaioni, G; Masi, A; Ranieri, G; Scardigli, M; Silvestri, L, 2022) |
| "Prenatal exposure to valproic acid (VPA) has been implicated in the manifestation of autism spectrum disorder (ASD)-like behavioral and functional changes both in human and rodents including mice and rats." | 4.12 | Metabolomics profiling of valproic acid-induced symptoms resembling autism spectrum disorders using 1H NMR spectral analysis in rat model. ( Kim, HY; Kim, JW; Kim, KB; Kim, S; Kim, SJ; Ko, MJ; Lee, JD; Lee, YJ; Shin, CY, 2022) |
| "The cilostazol regimen, attenuated prenatal VPA exposure associated hyperlocomotion, social interaction deficits, repetitive behavior, and anxiety." | 4.02 | Cilostazol attenuated prenatal valproic acid-induced behavioural and biochemical deficits in a rat model of autism spectrum disorder. ( Kulkarni, GT; Luhach, K; Sharma, B; Singh, VP, 2021) |
| "Prenatal uptake of valproic acid (VPA) was associated with increased risk of fetal cardiac anomalies and autism spectrum disorder (ASD), but uptake of VPA is considered the only effective treatment for epilepsy and other neurological disorders." | 4.02 | Effect of Valproic Acid on Maternal - Fetal Heart Rates and Coupling in Mice on Embryonic day 15.5 (E15.5). ( Fukase, M; Kasahara, Y; Khandoker, A; Kimura, Y; Nakanishi, K; Saito, M; Suzuki, A; Widatalla, N; Yoshida, C, 2021) |
| "In this study, we performed 16S rRNA gene sequencing and untargeted metabolomics in parallel on fecal samples from a valproic acid (VPA)-induced rat model of autism (VPA rats)." | 4.02 | Sex-specific differences in the gut microbiota and fecal metabolites in an adolescent valproic acid-induced rat autism model. ( Cui, YN; Gu, YY; Han, Y; Liang, JJ; Qin, J; Zhang, B; Zhang, SB; Zhang, Y, 2021) |
| " We exploited 2 different animal models of autism, the methyl CpG binding protein 2-null (Mecp2y/-) mouse model of Rett syndrome and mice prenatally exposed to valproic acid, and found increased ATM levels." | 4.02 | The DNA repair protein ATM as a target in autism spectrum disorder. ( Antonucci, F; Bifari, F; Cambria, C; Desiato, G; Ferrara, S; Focchi, E; Landsberger, N; Matteoli, M; Menna, E; Murru, L; Passafaro, M; Pizzamiglio, L; Ponzoni, L; Sala, M, 2021) |
| "Prenatal exposure to the antiepileptic drug (AED) valproic acid (VPA) is associated with an increased risk of impaired postnatal neurodevelopment, including autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD)." | 4.02 | Prenatal valproate exposure and adverse neurodevelopmental outcomes: Does sex matter? ( Anderson, A; Graham, J; Hitchcock, A; Honybun, E; Malpas, CB; O'Brien, TJ; Perucca, P; Rayner, G; Thwaites, R; Vajda, FJE, 2021) |
| " The present work detected the effects of pregnancy supplementation with folic acid (FA) at different doses on rat models of ASD induced by prenatal exposure to valproic acid (VPA), an anti-epileptic increasing the risk of ASD when administered during pregnancy." | 4.02 | Maternal folic acid supplementation prevents autistic behaviors in a rat model induced by prenatal exposure to valproic acid. ( Cheng, Q; Di, Y; Fan, J; Kang, M; Lan, J; Li, J; Li, Z; Ren, W; Tian, Y; Wei, C; Zhai, C; Zheng, Q, 2021) |
| " Exposure to the antiepileptic drug valproic acid (VPA) during pregnancy significantly increases the risk of ASD in humans, and consequently is utilized as a validated animal model of ASD in rodents; however, the precise molecular and cellular mechanisms remain ill-defined." | 4.02 | Abnormal spatiotemporal expression pattern of progranulin and neurodevelopment impairment in VPA-induced ASD rat model. ( Chen, D; Hu, Y; Lan, J; Li, Y; Liao, A; Wang, S; Wang, X; Wang, Y; Yang, F; Zheng, W, 2021) |
| "Prenatal exposure to the antiepileptic valproic acid (VPA) is associated with an increased risk of autism spectrum disorder (ASD) in humans." | 3.96 | In utero exposure to valproic acid disrupts ascending projections to the central nucleus of the inferior colliculus from the auditory brainstem. ( Fech, T; Kulesza, RJ; Mansour, Y; Smith, A; Zimmerman, R, 2020) |
| "Valproic acid (VPA) administered to mice during the early postnatal period causes social, cognitive, and motor deficits similar to those observed in humans with autism spectrum disorder (ASD)." | 3.96 | Long-lasting Behavioral and Neuroanatomical Effects of Postnatal Valproic Acid Treatment. ( Derbaly, A; Gifford, JJ; Kusnecov, AW; Norton, SA; Pawlak, AP; Sherman, SL; Wagner, GC; Zhang, H, 2020) |
| " This study examined the effect of metformin on VPA-induced autism spectrum disorders in rats." | 3.96 | Novel potential of metformin on valproic acid-induced autism spectrum disorder in rats: involvement of antioxidant defence system. ( Adeyemi, OO; Balogun, AO; Ishola, IO, 2020) |
| " In this study, we examined behavioral and hippocampal neurogenesis alterations in male offspring of rats exposed to valproic acid (VPA) during pregnancy." | 3.91 | Prenatal exposure to valproic acid is associated with altered neurocognitive function and neurogenesis in the dentate gyrus of male offspring rats. ( Arai, H; Bolati, K; Fukuhara, T; Ito, M; Kinjo, T; Seki, T; Suzuki, T, 2019) |
| " Maternal exposure to valproic acid (VPA), a commonly prescribed antiepileptic drug during pregnancy in human, has long been considered a risk factor to contribute to ASD susceptibility in offspring from epidemiological studies in humans." | 3.91 | Maternal valproic acid exposure leads to neurogenesis defects and autism-like behaviors in non-human primates. ( Guo, X; Jiang, YH; Li, XJ; Tu, Z; Wang, Q; Xu, HJ; Yan, T; Yu, HP; Zhang, Y; Zhang, YQ; Zhao, H; Zhou, H, 2019) |
| "Prenatal exposure to the antiepileptic valproic acid (VPA) is associated with an increased risk of autism spectrum disorder (ASD) in humans and is used as an animal model of ASD." | 3.91 | Auditory Midbrain Hypoplasia and Dysmorphology after Prenatal Valproic Acid Exposure. ( Chosky, D; Kulesza, RJ; Mangold, S; Mansour, Y, 2019) |
| " Valproic acid (VPA) is an anticonvulsant drug in both human and rodents with teratogenic effects during pregnancy." | 3.91 | Benefits of Fenofibrate in prenatal valproic acid-induced autism spectrum disorder related phenotype in rats. ( Mirza, R; Sharma, B, 2019) |
| "Abnormally high levels of homocysteine (Hcy) are associated with autism spectrum disorder." | 3.91 | Betaine ameliorates prenatal valproic-acid-induced autism-like behavioral abnormalities in mice by promoting homocysteine metabolism. ( Chen, X; Chen, Z; Cui, C; Huang, F; Jiang, X; Niu, J; Sun, J, 2019) |
| "Postnatal exposure to valproic acid (VPA) in rodents induces autism-like neurobehavioral defects which are comparable to the motor and cognitive deficits observed in humans with autism spectrum disorder (ASD)." | 3.91 | The dual-active histamine H3 receptor antagonist and acetylcholine esterase inhibitor E100 ameliorates stereotyped repetitive behavior and neuroinflammmation in sodium valproate induced autism in mice. ( Azimullah, S; Beiram, R; Eissa, N; Jayaprakash, P; Jayaraj, RL; Kieć-Kononowicz, K; Ojha, SK; Reiner, D; Sadek, B; Stark, H; Łażewska, D, 2019) |
| " In this study, we examined how exposure to valproic acid (VPA) during pregnancy is associated with an increased incidence of ASD." | 3.88 | Dendritic spine anomalies and PTEN alterations in a mouse model of VPA-induced autism spectrum disorder. ( Ahn, S; Cho, K; Choi, M; Kim, H; Kim, HS; Mahmood, U; Regan, P; Yang, EJ, 2018) |
| "Here, we aimed at determining whether a well-acknowledged animal model of autism spectrum disorders, the valproic acid model, displays motor impairments and whether they may correlate with social deficits and neuronal loss within motor brain areas." | 3.88 | Motor Impairments Correlate with Social Deficits and Restricted Neuronal Loss in an Environmental Model of Autism. ( Al Sagheer, T; Balbous, A; Fernagut, PO; Francheteau, M; Haida, O; Jaber, M; Matas, E, 2018) |
| " Here, we investigate the impact on the corticostriosomal pathway in the valproic acid (VPA)-induced autism spectrum disorder mouse model." | 3.85 | Valproic acid induces aberrant development of striatal compartments and corticostriatal pathways in a mouse model of autism spectrum disorder. ( Kuo, HY; Liu, FC, 2017) |
| "Rodents exposed prenatally to valproic acid (VPA) exhibit autism spectrum disorder (ASD)-like behavioral abnormalities." | 3.85 | Risperidone and aripiprazole alleviate prenatal valproic acid-induced abnormalities in behaviors and dendritic spine density in mice. ( Ago, Y; Hara, Y; Hasebe, S; Hashimoto, H; Kawase, H; Matsuda, T; Nakazawa, T; Takuma, K; Tanabe, W; Taruta, A; Tsukada, S, 2017) |
| "Prenatal exposure to the antiepileptic, mood-stabilizing drug, valproic acid (VPA), increases the incidence of autism spectrum disorders (ASDs); in utero administration of VPA to pregnant rodents induces ASD-like behaviors such as repetitive, stereotyped activity, and decreased socialization." | 3.85 | Sexually Dimorphic Epigenetic Regulation of Brain-Derived Neurotrophic Factor in Fetal Brain in the Valproic Acid Model of Autism Spectrum Disorder. ( Densmore, AL; Konopko, MA; Krueger, BK, 2017) |
| " Its etiology is still unknown, but different environmental factors during pregnancy, such as exposure to valproic acid (VPA), are associated with high incidence of ASD in children." | 3.85 | The effect of ketogenic diet in an animal model of autism induced by prenatal exposure to valproic acid. ( Baronio, D; Castro, K; Gottfried, C; Perry, IS; Riesgo, RDS, 2017) |
| "Prenatal exposure to valproic acid (VPA) enhances the risk for later development of autism spectrum disorders (ASD)." | 3.85 | Increased GABAA receptor binding in amygdala after prenatal administration of valproic acid to rats. ( Bertelsen, F; Drasbek, KR; Folloni, D; Landau, AM; Møller, A; Scheel-Krüger, J, 2017) |
| "Rodents exposed to valproic acid (VPA) in prenatal life exhibit post-natal characteristics analogous to autism spectrum disorder (ASD)." | 3.83 | A single low dose of valproic acid in late prenatal life alters postnatal behavior and glutamic acid decarboxylase levels in the mouse. ( Cheung, C; Chua, SE; Lam, S; Leung, J; Li, Q; McAlonan, GM; Sham, PC; Wei, R; Zhang, X, 2016) |
| "Valproic acid administration during gestational period causes behavior and biochemical deficits similar to those observed in humans with autism spectrum disorder." | 3.81 | Benefits of agomelatine in behavioral, neurochemical and blood brain barrier alterations in prenatal valproic acid induced autism spectrum disorder. ( Kumar, H; Sharma, B; Sharma, BM, 2015) |
| " The mainstay of treatment is with multiple anti-seizure medications (ASMs); however, the ASMs themselves can be associated with psychobehavioural adverse events, and effects (negative or positive) on cognition and sleep." | 2.82 | Psychobehavioural and Cognitive Adverse Events of Anti-Seizure Medications for the Treatment of Developmental and Epileptic Encephalopathies. ( Schubert-Bast, S; Strzelczyk, A, 2022) |
| "Valproic acid (VPA) is a broad-spectrum, antiepileptic drug, and it is also a potent teratogen." | 2.72 | Emerging mechanisms of valproic acid-induced neurotoxic events in autism and its implications for pharmacological treatment. ( Fukunaga, K; Han, F; Lin, W; Meng, F; Naveed, M; Taleb, A; Xu, X; Zhang, G; Zhou, QG, 2021) |
| "The term of autism spectrum disorders (ASD) is used to account for the diversity of symptoms that characterize this pathology." | 2.61 | [The valproate model of autism]. ( Bossu, JL; Roux, S, 2019) |
| "For patients with migraine, the pregnancy labeling of VPA will be changed from Category "D" to "X." | 2.50 | Risks of neurobehavioral teratogenicity associated with prenatal exposure to valproate monotherapy: a systematic review with regulatory repercussions. ( Gentile, S, 2014) |
| "Valproic acid (VPA) is an effective drug, which is preferred for the treatments of epilepsy and various kinds of seizures." | 2.44 | The effects of valproic acid neurotoxicity on aggressive behavior in zebrafish autism model. ( Feng, T; Li, X; Lu, W, 2024) |
| "In order to develop better treatments for autism spectrum disorder (ASD) it is critical to understand the developmental trajectory of the disorder and the accompanying brain changes." | 1.91 | Adolescent female valproic acid rats have impaired extra-dimensional shifts of attention and enlarged anterior cingulate cortices. ( Bossmann, SH; Challans, B; Davison, T; King, C; Mali, I; Maze, TR; Payne, M; Plakke, B, 2023) |
| "Thymol is a bioactive monoterpene isolated from Thymus vulgaris that has anti-inflammatory properties and is helpful in neurodevelopmental disorders." | 1.91 | Thymol improves autism-like behaviour in VPA-induced ASD rats through the Pin1/p38 MAPK pathway. ( Chen, J; Li, Y; Lv, M; Tang, B; Wang, F; Xiong, Y; Zhang, H, 2023) |
| "Aripiprazole (APZ) is an atypical antipsychotic that can safeguard mice against autism-like behavior induced by valproic acid (VPA)." | 1.91 | Maternal treatment with aripiprazole prevents the development of a valproic acid-induced autism-like phenotype in juvenile male mice. ( de Andrade, GM; de Barros Viana, GS; de Oliveira Ferreira, E; Lima, FAV; Neves, KRT; Pessoa Gomes, JM, 2023) |
| "Valproic acid (VPA) is a known drug for treating epilepsy and mood disorders; however, it is not recommended for pregnant women because of its possible teratogenicity." | 1.91 | Neonatal Exposure to Valproate Induces Long-Term Alterations in Steroid Hormone Levels in the Brain Cortex of Prepubertal Rats. ( Cho, SH; Jang, EH; Kim, SA; Lee, J, 2023) |
| "Autism spectrum disorder is characterized by a variety of cellular and molecular abnormalities which leads to autism-associated behaviors." | 1.91 | Chronic acetyl-L-carnitine treatment alleviates behavioral deficits and neuroinflammation through enhancing microbiota derived-SCFA in valproate model of autism. ( Roghani, M; Sadr, SS; Sanaeierad, A; Zahedi, E, 2023) |
| "Many studies show that the number of cognitive impairmentscan be reduced by antagonists of the histamine H3 receptor (H3R)." | 1.91 | Amelioration of cognition impairments in the valproic acid-induced animal model of autism by ciproxifan, a histamine H3-receptor antagonist. ( Esmaeilpour, K; Sepehri, G; Sheibani, V; Shekari, MA; Taheri, F, 2023) |
| "Autism has a strong genetic and heritable component; however, environmental factors including toxins, pesticides, infection and in utero exposure to drugs such as VPA have also been implicated in ASD." | 1.91 | Striatal synaptic changes and behavior in adult mouse upon prenatal exposure to valproic acid. ( Delgado-González, E; Durairaj, RV; Espinosa, F; Hernandez, A; Martínez-Torres, A; Reyes-Haro, D, 2023) |
| "Valproic acid (VPA) is a well-known anti-epileptic drug, but its prenatal exposure to animals causes social impairment, neurotransmitters imbalance, and neuroinflammation with ASD-like phenotypes." | 1.91 | Syringic acid alleviates valproic acid induced autism via activation of p38 mitogen-activated protein kinase: Possible molecular approach. ( Mallan, S; Singh, S, 2023) |
| "Valproic acid (VPA) is a widely prescribed antiepileptic drug with various medicinal efficacies." | 1.91 | Toxicity and teratogenicity effects of valproic acid on zebrafish (Danio rerio) embryos in relation to autism spectrum disorder. ( Azmai, MNA; Bakar, NA; Chong, SG; Fadzar, MSIM; Fahmi, MSAM; Faudzi, SMM; Hamid, NNAZZ; Ibrahim, WNW; Mastuki, SN; Norazhar, AI; Ramlan, NF; Saleh Hodin, NA; Zulkifli, AR, 2023) |
| "Valproic acid (VPA) was administered on embryonic day 12 (E12) to induce ASD, and lysophosphatidylinositol (LPI), a GPR55 agonist, was used prenatally to modulate the receptor activity." | 1.91 | Modulation of PI3K/Akt/GSK3β signaling cascade through G protein-coupled receptor 55 (GPR55) activation: Prenatal lysophosphatidylinositol attenuates valproic acid-induced synaptic abnormalities and mitochondrial dysfunction. ( Abir, AH; Ahmed, S; Akter, A; Hasan, MM; Khurshid, N; Nakshy, NT; Rahman, M; Sharmin, O; Yesmine, S, 2023) |
| "Investigations into the etiology of autism spectrum disorders have been largely confined to two realms: variations in DNA sequence and somatic developmental exposures." | 1.72 | Beyond Genes: Germline Disruption in the Etiology of Autism Spectrum Disorders. ( Corces, VG; Escher, J; Hernandez, A; Rissman, EF; Wang, HV; Yan, W, 2022) |
| "The mouse model of autism induced by prenatal exposure to valproic acid (VPA) was used to assess the therapeutic potential of STX209 on autism‑like behaviour in the present study." | 1.72 | The GABAB receptor agonist STX209 reverses the autism‑like behaviour in an animal model of autism induced by prenatal exposure to valproic acid. ( Chang, H; Ding, J; Gao, C; He, M; Jiang, S; Li, W; Sun, T; Sun, Y; Wang, F; Wang, Y; Xiao, L; Zhu, C, 2022) |
| " Pregnant C57BL/6 J mice were intraperitoneally injected with a dosage of 500 mg/kg valproic acid (VPA) on embryonic day 10." | 1.72 | Size anomaly and alteration of GABAergic enzymes expressions in cerebellum of a valproic acid mouse model of autism. ( Kwan, KM; Ma, SY, 2022) |
| "Valproic acid (VPA) is a widely prescribed drug to treat epilepsy, bipolar disorder, and migraine." | 1.72 | Aberrant induction of p19Arf-mediated cellular senescence contributes to neurodevelopmental defects. ( Keyes, WM; Klein, A; Knauer-Meyer, T; Plassat, JL; Rhinn, M; Zapata-Bodalo, I, 2022) |
| "However, the development of the autism-related gut microbiota and its relationship with intestinal dysfunction in ASD remain unclear." | 1.72 | Congenitally underdeveloped intestine drives autism-related gut microbiota and behavior. ( Chen, M; Cheng, M; Gao, X; He, Y; Li, H; Li, J; Li, Z; Liu, F; Meng, F; Qing, W; Shen, W; Shi, Y; Wang, H; Wang, Q; Wu, F; Zeng, N; Zhou, H, 2022) |
| "Autism spectrum disorder is a developmental disorder that can affect social interactions and sensory-motor behaviors." | 1.72 | Sex difference in cognitive behavioral alterations and barrel cortex neuronal responses in rats exposed prenatally to valproic acid under continuous environmental enrichment. ( Afarinesh, MR; Joushy, S; Mafi, F; Mollashahi, M; Sabzalizadeh, M; Sheibani, V, 2022) |
| "Sulforaphane (SFN) was employed as a bioactive compound and then encapsulated into Evs using three methods including passive (incubation), active (sonication), and active-passive (sonication-incubation)." | 1.72 | Sustained release of sulforaphane by bioactive extracellular vesicles for neuroprotective effect on chick model. ( Saeidifar, M; Shahlaei, M; Zamanian, A, 2022) |
| "Autism spectrum disorder is a neurodevelopmental disorder characterized by sensory abnormalities, social skills impairment and cognitive deficits." | 1.72 | Alterations in the intrinsic discharge activity of CA1 pyramidal neurons associated with possible changes in the NADPH diaphorase activity in a rat model of autism induced by prenatal exposure to valproic acid. ( Behzadi, G; Borjkhani, M; Davoudi, S; Hajisoltani, R; Hosseinmardi, N; Janahmadi, M; Karimi, SA; Khatibi, VA; Rahdar, M, 2022) |
| "Previous studies have indicated that autism-like behavioral phenotypes detected in F1 VPA mice transgenetically appear in F2 and F3 generations." | 1.72 | Early-onset of social communication and locomotion activity in F2 pups of a valproic acid-induced mouse model of autism. ( Fu, P; Furuhara, K; Higashida, H; Minami, K; Mizutani, R; Tsuji, C; Tsuji, T; Yokoyama, S; Zhong, J, 2022) |
| " We found that gestational VPA exposure via chronic maternal oral dosing was associated with substantial drug-induced differential gene expression in the pup brains, including dysregulated splicing, and observed that this occurred in the absence of evidence for significant neuronal gain or loss." | 1.72 | Integrative genomics reveals pathogenic mediator of valproate-induced neurodevelopmental disability. ( Abouzeid, M; Feleke, R; Jazayeri, D; Johnson, MR; Jones, NC; O'Brien, TJ; Powell, KL; Srivastava, PK, 2022) |
| "Melatonin is an endogenous hormone and can restore gut microbial dysbiosis under various disease conditions." | 1.72 | Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism. ( Cui, Y; Li, XG; Liu, W; Liu, X; Qiu, B; Wang, X; Xiang, G; Yu, M; Zhang, D; Zhang, Y, 2022) |
| "Valproic acid (VPA) is a potential teratogenic agent, and prenatal exposure can cause autism-like symptoms including repetitive behaviors and defective sociability." | 1.72 | Continuous high-frequency deep brain stimulation of the anterior insula modulates autism-like behavior in a valproic acid-induced rat model. ( Feng, Y; Gao, C; Guo, B; Huo, X; Jiang, S; Li, W; Liu, C; Sun, T; Sun, Y; Wang, A; Wang, C; Wang, F; Wang, Y; Xiao, L, 2022) |
| "Valproic acid (VPA) is an antiepileptic drug with a pronounced teratogenic effect associated with a high risk of ASD, and its administration to rats during the gestation is used for autism modeling." | 1.62 | Assessment of behavioral, morphological and electrophysiological changes in prenatal and postnatal valproate induced rat models of autism spectrum disorder. ( Chavushyan, V; Danielyan, M; Fereshetyan, K; Yenkoyan, K, 2021) |
| "Autism spectrum disorder is associated with alterations in GABAergic and glutamatergic neurotransmission." | 1.62 | Brain and plasma amino acid concentration in infant rats prenatally exposed to valproic acid. ( BeltrÁn-Parrazal, L; LÓpez-Meraz, ML; Morgado-Valle, C; Puig-Lagunes, ÁA; Rocha, L, 2021) |
| "Neuroinflammation was measured by assessing microglia and astrocyte population in the prefrontal cortex (PFC) and cerebellum (CER) of pups." | 1.62 | Mycobacterium tuberculosis causes a leaky blood-brain barrier and neuroinflammation in the prefrontal cortex and cerebellum regions of infected mice offspring. ( Manjeese, W; Mpofana, T; Mvubu, NE; Steyn, AJC, 2021) |
| "Treatment with pioglitazone significantly attenuated the prenatal VPA-induced social impairment, repetitive behavior, hyperactivity, anxiety and low exploratory activity." | 1.51 | Beneficial effects of pioglitazone, a selective peroxisome proliferator-activated receptor-γ agonist in prenatal valproic acid-induced behavioral and biochemical autistic like features in Wistar rats. ( Mirza, R; Sharma, B, 2019) |
| "Autism spectrum disorders affect millions of individuals worldwide, but their heterogeneity complicates therapeutic intervention that is essentially symptomatic." | 1.43 | Human Pluripotent Stem Cell-derived Cortical Neurons for High Throughput Medication Screening in Autism: A Proof of Concept Study in SHANK3 Haploinsufficiency Syndrome. ( Benchoua, A; Boissart, C; Bourgeron, T; Chatrousse, L; Cogé, F; Darville, H; Delorme, R; Héron, D; Jarrige, M; Millan, MJ; Nava, C; Pernelle, J; Perrier, A; Peschanski, M; Poulet, A; Rodet-Amsellem, F, 2016) |
| "Epilepsy is common in individuals with autism spectrum disorder (ASD) and intellectual disabilities (ID)." | 1.42 | Impact of epilepsy and antiepileptic medications on the metabolic profile in adults with autism spectrum disorder and intellectual disabilities. ( Katz, N; Moses, L; Weizman, A, 2015) |
| "Previously, autism spectrum disorder (ASD) has been identified mainly by social communication deficits and behavioral symptoms." | 1.42 | Alteration of spontaneous spectral powers and coherences of local field potential in prenatal valproic acid mouse model of autism. ( Cheaha, D; Kumarnsit, E, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 64 (29.22) | 24.3611 |
| 2020's | 155 (70.78) | 2.80 |
| Authors | Studies |
|---|---|
| Luhach, K | 3 |
| Kulkarni, GT | 3 |
| Singh, VP | 3 |
| Sharma, B | 6 |
| Harding, SM | 1 |
| Masters, EC | 1 |
| D'Agata, CM | 1 |
| Agudelo Rivera, AC | 1 |
| Smith, EC | 1 |
| Watanabe, S | 1 |
| Kurotani, T | 1 |
| Oga, T | 2 |
| Noguchi, J | 1 |
| Isoda, R | 1 |
| Nakagami, A | 2 |
| Sakai, K | 1 |
| Nakagaki, K | 3 |
| Sumida, K | 2 |
| Hoshino, K | 2 |
| Saito, K | 2 |
| Miyawaki, I | 2 |
| Sekiguchi, M | 1 |
| Wada, K | 1 |
| Minamimoto, T | 2 |
| Ichinohe, N | 3 |
| Alhelo, H | 1 |
| Kulesza, RJ | 6 |
| Escher, J | 1 |
| Yan, W | 1 |
| Rissman, EF | 1 |
| Wang, HV | 1 |
| Hernandez, A | 2 |
| Corces, VG | 1 |
| Joseph, TP | 1 |
| Zhou, F | 1 |
| Sai, LY | 1 |
| Chen, H | 1 |
| Lin, SL | 1 |
| Schachner, M | 1 |
| Lotufo Denucci, B | 1 |
| Silva de Lima, L | 1 |
| Ferreira Lima Mota, I | 1 |
| Rocha Madureira Azevedo, J | 1 |
| Germino Veras, L | 1 |
| Montenegro Luzardo Bicca, JV | 1 |
| de Miranda Santana, B | 1 |
| Beserra Pinheiro, G | 1 |
| Gonçalves Coelho, G | 1 |
| Mortari, MR | 1 |
| Fereshetyan, K | 1 |
| Chavushyan, V | 1 |
| Danielyan, M | 1 |
| Yenkoyan, K | 1 |
| Widatalla, N | 1 |
| Khandoker, A | 1 |
| Yoshida, C | 1 |
| Nakanishi, K | 1 |
| Fukase, M | 1 |
| Suzuki, A | 1 |
| Kasahara, Y | 1 |
| Saito, M | 1 |
| Kimura, Y | 1 |
| Viamontes, CG | 1 |
| Castillo Gonzalez, J | 1 |
| Najjar, F | 1 |
| Cook, EH | 1 |
| Gu, YY | 1 |
| Han, Y | 1 |
| Liang, JJ | 1 |
| Cui, YN | 1 |
| Zhang, B | 1 |
| Zhang, Y | 7 |
| Zhang, SB | 1 |
| Qin, J | 1 |
| Elnahas, EM | 2 |
| Abuelezz, SA | 1 |
| Mohamad, MI | 2 |
| Nabil, MM | 1 |
| Abdelraouf, SM | 1 |
| Bahaa, N | 1 |
| Hassan, GAM | 2 |
| Aboul-Fotouh, S | 3 |
| Lin, J | 1 |
| Zhang, K | 1 |
| Cao, X | 1 |
| Zhao, Y | 3 |
| Ullah Khan, N | 1 |
| Liu, X | 6 |
| Tang, X | 1 |
| Chen, M | 2 |
| Zhang, H | 3 |
| Shen, L | 1 |
| Vakili Shahrbabaki, SS | 1 |
| Jonaidi, H | 1 |
| Sheibani, V | 6 |
| Bashiri, H | 3 |
| Błaszczyk, B | 1 |
| Miziak, B | 1 |
| Pluta, R | 1 |
| Czuczwar, SJ | 1 |
| Cheng, Y | 1 |
| Tang, B | 3 |
| Zhang, G | 2 |
| An, P | 1 |
| Sun, Y | 5 |
| Gao, M | 1 |
| Shan, Y | 1 |
| Zhang, J | 2 |
| Liu, Q | 1 |
| Lai, CSW | 1 |
| de Villers-Sidani, É | 1 |
| Wang, Y | 8 |
| Zhou, X | 1 |
| Bódi, V | 1 |
| Májer, T | 1 |
| Kelemen, V | 1 |
| Világi, I | 1 |
| Szűcs, A | 1 |
| Varró, P | 1 |
| Jiang, S | 3 |
| Xiao, L | 3 |
| He, M | 1 |
| Gao, C | 3 |
| Zhu, C | 1 |
| Chang, H | 1 |
| Ding, J | 1 |
| Li, W | 3 |
| Sun, T | 3 |
| Wang, F | 4 |
| Santrač, A | 1 |
| Bijelić, D | 1 |
| Stevanović, V | 1 |
| Banićević, M | 1 |
| Aranđelović, J | 1 |
| Batinić, B | 1 |
| Sharmin, D | 1 |
| Cook, JM | 1 |
| Savić, MM | 1 |
| Wang, L | 1 |
| Chen, J | 6 |
| Hu, Y | 2 |
| Liao, A | 2 |
| Zheng, W | 2 |
| Wang, X | 6 |
| Lan, J | 3 |
| Shen, J | 1 |
| Wang, S | 2 |
| Yang, F | 2 |
| Li, Y | 6 |
| Chen, D | 2 |
| Abhishek, M | 1 |
| Rubal, S | 1 |
| Rohit, K | 1 |
| Rupa, J | 1 |
| Phulen, S | 1 |
| Gurjeet, K | 1 |
| Raj, SA | 1 |
| Manisha, P | 1 |
| Alka, B | 1 |
| Ramprasad, P | 1 |
| Bikash, M | 1 |
| Meng, Q | 1 |
| Zhang, W | 1 |
| Jiao, C | 1 |
| Xu, S | 1 |
| Liu, C | 4 |
| Chen, C | 1 |
| Imam, B | 1 |
| Rahmatinia, M | 1 |
| Shahsavani, A | 1 |
| Khodagholi, F | 1 |
| Hopke, PK | 1 |
| Bazazzpour, S | 1 |
| Hadei, M | 1 |
| Yarahmadi, M | 1 |
| Abdollahifar, MA | 1 |
| Torkmahalleh, MA | 1 |
| Kermani, M | 1 |
| Ilkhani, S | 1 |
| MirBehbahani, SH | 1 |
| Ma, SY | 1 |
| Kwan, KM | 1 |
| Elesawy, RO | 1 |
| El-Deeb, OS | 1 |
| Eltokhy, AK | 1 |
| Arakeep, HM | 1 |
| Ali, DA | 1 |
| Elkholy, SS | 1 |
| Kabel, AM | 1 |
| Santos-Terra, J | 5 |
| Deckmann, I | 4 |
| Carello-Collar, G | 1 |
| Nunes, GD | 1 |
| Bauer-Negrini, G | 2 |
| Schwingel, GB | 2 |
| Fontes-Dutra, M | 5 |
| Riesgo, R | 2 |
| Gottfried, C | 6 |
| Galizio, A | 1 |
| Odum, AL | 1 |
| Seiffe, A | 2 |
| Ramírez, MF | 1 |
| Sempé, L | 1 |
| Depino, AM | 5 |
| Taheri, F | 3 |
| Esmaeilpour, K | 3 |
| Sepehri, G | 3 |
| Ur Rehman, N | 1 |
| Maneshian, M | 1 |
| Liu, Z | 2 |
| Wang, J | 3 |
| Xu, Q | 1 |
| Wu, Z | 1 |
| You, L | 1 |
| Hong, Q | 1 |
| Zhu, J | 1 |
| Chi, X | 1 |
| Mehra, S | 1 |
| Ul Ahsan, A | 1 |
| Seth, E | 1 |
| Chopra, M | 1 |
| Dufour, A | 2 |
| Dumon, C | 2 |
| Gouty-Colomer, LA | 2 |
| Eftekhari, S | 2 |
| Ferrari, DC | 2 |
| Ben-Ari, Y | 2 |
| Bjørk, MH | 1 |
| Zoega, H | 1 |
| Leinonen, MK | 1 |
| Cohen, JM | 1 |
| Dreier, JW | 1 |
| Furu, K | 1 |
| Gilhus, NE | 1 |
| Gissler, M | 1 |
| Hálfdánarson, Ó | 1 |
| Igland, J | 1 |
| Tomson, T | 1 |
| Alvestad, S | 1 |
| Christensen, J | 1 |
| Sivasangari, K | 1 |
| Rajan, KE | 1 |
| Wang, Z | 1 |
| Zhang, X | 2 |
| Zhang, D | 4 |
| Yang, Q | 1 |
| Hu, P | 1 |
| Li, F | 1 |
| Rhinn, M | 1 |
| Zapata-Bodalo, I | 1 |
| Klein, A | 1 |
| Plassat, JL | 1 |
| Knauer-Meyer, T | 1 |
| Keyes, WM | 1 |
| Li, J | 2 |
| Wang, H | 1 |
| Qing, W | 1 |
| Liu, F | 1 |
| Zeng, N | 1 |
| Wu, F | 1 |
| Shi, Y | 1 |
| Gao, X | 1 |
| Cheng, M | 1 |
| Li, H | 2 |
| Shen, W | 1 |
| Meng, F | 2 |
| He, Y | 1 |
| Li, Z | 3 |
| Zhou, H | 2 |
| Wang, Q | 2 |
| Sabzalizadeh, M | 1 |
| Mollashahi, M | 1 |
| Afarinesh, MR | 2 |
| Mafi, F | 1 |
| Joushy, S | 1 |
| Shahlaei, M | 1 |
| Saeidifar, M | 1 |
| Zamanian, A | 1 |
| Avolio, E | 1 |
| Olivito, I | 1 |
| Rosina, E | 1 |
| Romano, L | 1 |
| Angelone, T | 1 |
| De Bartolo, A | 1 |
| Scimeca, M | 1 |
| Bellizzi, D | 1 |
| D'Aquila, P | 1 |
| Passarino, G | 1 |
| Alò, R | 1 |
| Facciolo, RM | 1 |
| Bagni, C | 1 |
| De Lorenzo, A | 1 |
| Canonaco, M | 1 |
| Chu, MC | 3 |
| Wu, HF | 3 |
| Lee, CW | 2 |
| Chung, YJ | 1 |
| Chi, H | 1 |
| Chen, PS | 3 |
| Lin, HC | 3 |
| Rahdar, M | 4 |
| Hajisoltani, R | 3 |
| Davoudi, S | 4 |
| Karimi, SA | 2 |
| Borjkhani, M | 2 |
| Khatibi, VA | 1 |
| Hosseinmardi, N | 4 |
| Behzadi, G | 4 |
| Janahmadi, M | 4 |
| Ishihara, Y | 1 |
| Honda, T | 1 |
| Ishihara, N | 1 |
| Namba, K | 1 |
| Taketoshi, M | 1 |
| Tominaga, Y | 1 |
| Tsuji, M | 1 |
| Vogel, CFA | 1 |
| Yamazaki, T | 1 |
| Itoh, K | 1 |
| Tominaga, T | 1 |
| Takayama, K | 1 |
| Tobori, S | 1 |
| Andoh, C | 1 |
| Kakae, M | 1 |
| Hagiwara, M | 1 |
| Nagayasu, K | 1 |
| Shirakawa, H | 1 |
| Ago, Y | 3 |
| Kaneko, S | 1 |
| Tsuji, C | 3 |
| Furuhara, K | 2 |
| Mizutani, R | 2 |
| Minami, K | 2 |
| Fu, P | 1 |
| Zhong, J | 1 |
| Higashida, H | 1 |
| Yokoyama, S | 1 |
| Tsuji, T | 3 |
| Kim, H | 2 |
| Woo, RS | 1 |
| Yang, EJ | 2 |
| Kim, HB | 1 |
| Jo, EH | 1 |
| Lee, S | 1 |
| Im, H | 1 |
| Kim, S | 4 |
| Kim, HS | 2 |
| Anshu, K | 2 |
| Nair, AK | 2 |
| Srinath, S | 2 |
| Laxmi, TR | 2 |
| Mansour, Y | 3 |
| Burchell, A | 1 |
| Kulesza, R | 2 |
| Iezzi, D | 1 |
| Curti, L | 1 |
| Ranieri, G | 1 |
| Gerace, E | 1 |
| Costa, A | 1 |
| Ilari, A | 1 |
| La Rocca, A | 1 |
| Luceri, C | 1 |
| D'Ambrosio, M | 1 |
| Silvestri, L | 1 |
| Scardigli, M | 1 |
| Mannaioni, G | 1 |
| Masi, A | 1 |
| Serra, D | 1 |
| Henriques, JF | 1 |
| Sousa, FJ | 1 |
| Laranjo, M | 1 |
| Resende, R | 1 |
| Ferreira-Marques, M | 1 |
| de Freitas, V | 1 |
| Silva, G | 1 |
| Peça, J | 1 |
| Dinis, TCP | 1 |
| Almeida, LM | 1 |
| Imado, E | 1 |
| Sun, S | 1 |
| Abawa, AR | 1 |
| Tahara, T | 1 |
| Kochi, T | 1 |
| Huynh, TNB | 1 |
| Asano, S | 1 |
| Hasebe, S | 2 |
| Nakamura, Y | 1 |
| Hisaoka-Nakashima, K | 1 |
| Kotake, Y | 1 |
| Irifune, M | 1 |
| Tsuga, K | 1 |
| Takuma, K | 2 |
| Morioka, N | 1 |
| Kiguchi, N | 1 |
| Feleke, R | 1 |
| Jazayeri, D | 1 |
| Abouzeid, M | 1 |
| Powell, KL | 1 |
| Srivastava, PK | 1 |
| O'Brien, TJ | 2 |
| Jones, NC | 1 |
| Johnson, MR | 1 |
| Singla, R | 4 |
| Mishra, A | 4 |
| Joshi, R | 2 |
| Sarma, P | 2 |
| Kumar, R | 2 |
| Kaur, G | 2 |
| Sharma, AR | 3 |
| Jain, A | 3 |
| Prakash, A | 2 |
| Bhatia, A | 3 |
| Medhi, B | 4 |
| Sharma, A | 2 |
| Prajapat, M | 1 |
| Strzelczyk, A | 1 |
| Schubert-Bast, S | 1 |
| Cui, Y | 3 |
| Xiang, G | 3 |
| Yu, M | 3 |
| Qiu, B | 3 |
| Li, XG | 3 |
| Liu, W | 3 |
| Maisterrena, A | 3 |
| Matas, E | 4 |
| Mirfendereski, H | 3 |
| Balbous, A | 4 |
| Marchand, S | 3 |
| Jaber, M | 5 |
| Galineau, L | 3 |
| Arlicot, N | 3 |
| Dupont, AC | 3 |
| Briend, F | 3 |
| Houy-Durand, E | 3 |
| Tauber, C | 3 |
| Gomot, M | 3 |
| Gissot, V | 3 |
| Barantin, L | 3 |
| Lefevre, A | 3 |
| Vercouillie, J | 3 |
| Roussel, C | 3 |
| Roux, S | 4 |
| Nadal, L | 3 |
| Mavel, S | 3 |
| Laumonnier, F | 3 |
| Belzung, C | 3 |
| Chalon, S | 3 |
| Emond, P | 3 |
| Santiago-Ribeiro, MJ | 3 |
| Bonnet-Brilhault, F | 3 |
| Cipriani, C | 3 |
| Giudice, M | 3 |
| Petrone, V | 3 |
| Fanelli, M | 3 |
| Minutolo, A | 3 |
| Miele, MT | 3 |
| Toschi, N | 3 |
| Maracchioni, C | 3 |
| Siracusano, M | 3 |
| Benvenuto, A | 3 |
| Coniglio, A | 3 |
| Curatolo, P | 3 |
| Mazzone, L | 3 |
| Sandro, G | 3 |
| Garaci, E | 3 |
| Sinibaldi-Vallebona, P | 3 |
| Matteucci, C | 3 |
| Balestrieri, E | 3 |
| Huo, X | 2 |
| Guo, B | 3 |
| Wang, C | 2 |
| Wang, A | 2 |
| Feng, Y | 2 |
| Righes Marafiga, J | 2 |
| Brum Schwingel, G | 2 |
| Rabelo, B | 2 |
| Kazmierzak de Moraes, R | 2 |
| Rockenbach, M | 2 |
| Vendramin Pasquetti, M | 2 |
| Calcagnotto, ME | 2 |
| Mali, I | 3 |
| Payne, M | 3 |
| King, C | 2 |
| Maze, TR | 2 |
| Davison, T | 2 |
| Challans, B | 3 |
| Bossmann, SH | 3 |
| Plakke, B | 4 |
| Viana, CE | 2 |
| Bortolotto, VC | 2 |
| Araujo, SM | 2 |
| Dahleh, MMM | 2 |
| Machado, FR | 2 |
| de Souza Pereira, A | 2 |
| Moreira de Oliveira, BP | 2 |
| Leimann, FV | 2 |
| Gonçalves, OH | 2 |
| Prigol, M | 2 |
| Guerra, GP | 2 |
| Xu, C | 2 |
| Zhou, Q | 1 |
| Chao, G | 1 |
| Jin, Y | 1 |
| Dixon, SC | 1 |
| Calder, BJ | 1 |
| Lilya, SM | 1 |
| Davies, BM | 1 |
| Martin, A | 1 |
| Peterson, M | 1 |
| Hansen, JM | 1 |
| Suli, A | 1 |
| Kim, UJ | 1 |
| Hong, N | 1 |
| Ahn, JC | 1 |
| Zheng, Y | 1 |
| Prince, N | 1 |
| van Hattem, C | 1 |
| Garssen, J | 1 |
| Pardo, PP | 1 |
| Kraneveld, AD | 1 |
| Leung, CS | 1 |
| Rosenzweig, SJ | 1 |
| Yoon, B | 1 |
| Marinelli, NA | 1 |
| Hollingsworth, EW | 1 |
| Maguire, AM | 1 |
| Cowen, MH | 1 |
| Schmidt, M | 1 |
| Imitola, J | 1 |
| Gamsiz Uzun, ED | 1 |
| Lizarraga, SB | 1 |
| Cao, Y | 1 |
| Hou, W | 1 |
| Bi, D | 1 |
| Yin, F | 1 |
| Gao, Y | 1 |
| Huang, D | 1 |
| Cao, Z | 1 |
| Yan, Y | 1 |
| Zhao, J | 1 |
| Kong, D | 1 |
| Lv, X | 1 |
| Huang, L | 1 |
| Zhong, H | 1 |
| Wu, C | 1 |
| Chen, Q | 1 |
| Yang, R | 1 |
| Wei, Q | 1 |
| Qin, H | 1 |
| Ornoy, A | 6 |
| Gorobets, D | 1 |
| Weinstein-Fudim, L | 5 |
| Becker, M | 2 |
| Xiong, Y | 1 |
| Lv, M | 1 |
| de Oliveira Ferreira, E | 1 |
| Pessoa Gomes, JM | 1 |
| Neves, KRT | 1 |
| Lima, FAV | 1 |
| de Barros Viana, GS | 1 |
| de Andrade, GM | 1 |
| Luo, L | 3 |
| Wu, Q | 2 |
| Yuan, B | 3 |
| Hu, C | 3 |
| Yang, T | 3 |
| Wei, H | 2 |
| Li, T | 4 |
| Zohny, SM | 1 |
| Habib, MZ | 2 |
| Elayat, WM | 1 |
| Elhossiny, RM | 1 |
| El-Salam, MFA | 1 |
| Shahrbabaki, SSV | 1 |
| Moslemizadeh, A | 2 |
| Amiresmaili, S | 1 |
| Tezerji, SS | 1 |
| Juybari, KB | 1 |
| Shamsi Meymandi, M | 1 |
| Guerra, M | 1 |
| Medici, V | 1 |
| Weatheritt, R | 1 |
| Corvino, V | 1 |
| Palacios, D | 1 |
| Geloso, MC | 1 |
| Farini, D | 1 |
| Sette, C | 1 |
| Kim, SA | 1 |
| Jang, EH | 1 |
| Lee, J | 1 |
| Cho, SH | 1 |
| Ahmadi, BBM | 1 |
| Jafaripour, L | 1 |
| Mirzavandi, F | 1 |
| Sabet, N | 1 |
| Aminzadeh, A | 1 |
| Heidari, M | 1 |
| Pouya, F | 1 |
| Parizi, AS | 1 |
| Yin, B | 1 |
| Zhao, P | 1 |
| Zheng, R | 1 |
| Feng, P | 1 |
| Li, E | 1 |
| Li, L | 1 |
| Anggadiredja, K | 1 |
| Kurniati, NF | 1 |
| Kasai, A | 1 |
| Hashimoto, H | 2 |
| Atia, AA | 1 |
| Ashour, RH | 1 |
| Zaki, MM | 1 |
| Rahman, KM | 1 |
| Ramadan, NM | 1 |
| Zahedi, E | 2 |
| Sadr, SS | 2 |
| Sanaeierad, A | 2 |
| Roghani, M | 2 |
| Shekari, MA | 1 |
| Zappala, C | 2 |
| Barrios, CD | 1 |
| Joushi, S | 1 |
| Ebrahimi, MN | 1 |
| Taheri Zadeh, Z | 1 |
| Lin, F | 1 |
| Jian, J | 1 |
| Li, LG | 1 |
| Zhao, PJ | 1 |
| Zheng, RJ | 1 |
| Dong, XW | 1 |
| Zhao, YH | 1 |
| Yin, BQ | 2 |
| Li, S | 2 |
| Cheng, H | 1 |
| Li, HL | 1 |
| Li, EY | 1 |
| Malhotra, AS | 1 |
| Sandhu, A | 1 |
| Rawat, K | 1 |
| Gautam, V | 1 |
| Kumar, A | 1 |
| Saha, L | 1 |
| Barzegari, A | 1 |
| Amouzad Mahdirejei, H | 1 |
| Hanani, M | 1 |
| Esmaeili, MH | 1 |
| Salari, AA | 1 |
| Delgado-González, E | 1 |
| Durairaj, RV | 1 |
| Reyes-Haro, D | 1 |
| Martínez-Torres, A | 1 |
| Espinosa, F | 1 |
| Hameed, RA | 1 |
| Ahmed, EK | 1 |
| Mahmoud, AA | 1 |
| Atef, AA | 1 |
| Mallan, S | 1 |
| Singh, S | 1 |
| Turpin, V | 1 |
| Schaffhauser, M | 1 |
| Thabault, M | 1 |
| Aubert, A | 1 |
| Joffre, C | 1 |
| Balado, E | 1 |
| Longueville, JE | 1 |
| Francheteau, M | 2 |
| Burucoa, C | 1 |
| Pichon, M | 1 |
| Layé, S | 1 |
| Aboul-Ela, YM | 1 |
| Ebeid, MA | 1 |
| Tarek, M | 1 |
| Sadek, DR | 1 |
| Negm, EA | 1 |
| Abdelhakam, DA | 1 |
| Lima-Castañeda, LÁ | 1 |
| Bringas, ME | 1 |
| Aguilar-Hernandez, L | 1 |
| Garcés-Ramírez, L | 1 |
| Morales-Medina, JC | 1 |
| Flores, G | 1 |
| Saleh Hodin, NA | 1 |
| Chong, SG | 1 |
| Bakar, NA | 1 |
| Fahmi, MSAM | 1 |
| Ramlan, NF | 1 |
| Hamid, NNAZZ | 1 |
| Fadzar, MSIM | 1 |
| Zulkifli, AR | 1 |
| Norazhar, AI | 1 |
| Mastuki, SN | 1 |
| Faudzi, SMM | 1 |
| Ibrahim, WNW | 1 |
| Azmai, MNA | 1 |
| Park, G | 1 |
| Jang, WE | 1 |
| Gonzales, EL | 3 |
| Ji, J | 1 |
| Choi, S | 1 |
| Kim, Y | 1 |
| Park, JH | 1 |
| Mohammad, HB | 1 |
| Bang, G | 1 |
| Kang, M | 2 |
| Jeon, SJ | 1 |
| Kim, JY | 1 |
| Kim, KP | 1 |
| Shin, CY | 6 |
| An, JY | 1 |
| Kim, MS | 1 |
| Lee, YS | 1 |
| Ma, L | 1 |
| Deng, Y | 1 |
| Du, Z | 1 |
| Yue, J | 1 |
| Saadat, M | 1 |
| Taherian, AA | 1 |
| Aldaghi, MR | 1 |
| Raise-Abdullahi, P | 1 |
| Sameni, HR | 1 |
| Vafaei, AA | 1 |
| D'Antoni, S | 1 |
| Schiavi, S | 2 |
| Buzzelli, V | 1 |
| Giuffrida, S | 1 |
| Feo, A | 1 |
| Ascone, F | 1 |
| Busceti, CL | 1 |
| Nicoletti, F | 1 |
| Trezza, V | 3 |
| Catania, MV | 1 |
| You, M | 2 |
| Yan, S | 1 |
| Yao, D | 1 |
| Wang, T | 1 |
| Ahmed, S | 1 |
| Abir, AH | 1 |
| Sharmin, O | 1 |
| Khurshid, N | 1 |
| Akter, A | 1 |
| Nakshy, NT | 1 |
| Hasan, MM | 1 |
| Yesmine, S | 1 |
| Rahman, M | 1 |
| Nakagami, Y | 1 |
| Nishi, M | 1 |
| Batra, G | 2 |
| Dhir, N | 1 |
| Modi, T | 1 |
| Saini, L | 2 |
| Thakur, N | 1 |
| Singh, RS | 2 |
| Singh, A | 2 |
| Goyal, M | 1 |
| Modi, M | 2 |
| Li, X | 1 |
| Feng, T | 1 |
| Lu, W | 1 |
| Kim, JW | 5 |
| Park, K | 2 |
| Kang, RJ | 2 |
| Oh, HA | 3 |
| Seung, H | 3 |
| Ko, MJ | 4 |
| Cheong, JH | 2 |
| Chung, C | 2 |
| Lu, TY | 2 |
| Kinjo, T | 1 |
| Ito, M | 1 |
| Seki, T | 1 |
| Fukuhara, T | 1 |
| Bolati, K | 1 |
| Arai, H | 1 |
| Suzuki, T | 1 |
| Kazlauskas, N | 2 |
| Campolongo, M | 2 |
| Mohammadi, S | 1 |
| Asadi-Shekaari, M | 1 |
| Basiri, M | 1 |
| Parvan, M | 1 |
| Shabani, M | 1 |
| Nozari, M | 1 |
| Zhao, H | 1 |
| Yan, T | 1 |
| Xu, HJ | 1 |
| Yu, HP | 1 |
| Tu, Z | 1 |
| Guo, X | 1 |
| Jiang, YH | 1 |
| Li, XJ | 1 |
| Zhang, YQ | 1 |
| Hara, Y | 2 |
| Zimmerman, R | 2 |
| Smith, A | 2 |
| Fech, T | 1 |
| Norton, SA | 1 |
| Gifford, JJ | 1 |
| Pawlak, AP | 1 |
| Derbaly, A | 1 |
| Sherman, SL | 1 |
| Wagner, GC | 1 |
| Kusnecov, AW | 1 |
| Fujisaku, T | 2 |
| Ergaz, Z | 4 |
| Szyf, M | 1 |
| Ishola, IO | 1 |
| Balogun, AO | 1 |
| Adeyemi, OO | 1 |
| Gąssowska-Dobrowolska, M | 1 |
| Cieślik, M | 1 |
| Czapski, GA | 1 |
| Jęśko, H | 1 |
| Frontczak-Baniewicz, M | 1 |
| Gewartowska, M | 1 |
| Dominiak, A | 1 |
| Polowy, R | 1 |
| Filipkowski, RK | 1 |
| Babiec, L | 1 |
| Adamczyk, A | 1 |
| Chatterjee, M | 1 |
| Singh, P | 1 |
| Xu, J | 1 |
| Lombroso, PJ | 1 |
| Kurup, PK | 1 |
| Ozkul, Y | 1 |
| Taheri, S | 1 |
| Bayram, KK | 1 |
| Sener, EF | 1 |
| Mehmetbeyoglu, E | 1 |
| Öztop, DB | 1 |
| Aybuga, F | 1 |
| Tufan, E | 1 |
| Bayram, A | 1 |
| Dolu, N | 1 |
| Zararsiz, G | 1 |
| Kianmehr, L | 1 |
| Beyaz, F | 1 |
| Doganyigit, Z | 1 |
| Cuzin, F | 1 |
| Rassoulzadegan, M | 1 |
| Chen, O | 1 |
| Tahmazian, I | 1 |
| Ferrara, HJ | 1 |
| Hu, B | 2 |
| Chomiak, T | 2 |
| Potasiewicz, A | 1 |
| Gzielo, K | 1 |
| Popik, P | 1 |
| Nikiforuk, A | 1 |
| Wu, M | 1 |
| Di, Y | 2 |
| Diao, Z | 1 |
| Yao, L | 1 |
| Qian, Z | 1 |
| Wei, C | 2 |
| Zheng, Q | 2 |
| Liu, Y | 1 |
| Han, J | 1 |
| Fan, J | 2 |
| Tian, Y | 2 |
| Ren, W | 2 |
| Kozhuhov, A | 1 |
| Tfilin, M | 1 |
| Turgeman, G | 1 |
| Yanai, J | 1 |
| Abookasis, D | 1 |
| Morales-Navas, M | 1 |
| Castaño-Castaño, S | 1 |
| Pérez-Fernández, C | 1 |
| Sánchez-Gil, A | 1 |
| Teresa Colomina, M | 1 |
| Leinekugel, X | 1 |
| Sánchez-Santed, F | 1 |
| Messina, A | 1 |
| Boiti, A | 1 |
| Sovrano, VA | 1 |
| Sgadò, P | 2 |
| McKinnell, ZE | 2 |
| Maze, T | 1 |
| Ramos, A | 1 |
| Wiggs, KK | 1 |
| Rickert, ME | 1 |
| Sujan, AC | 1 |
| Quinn, PD | 1 |
| Larsson, H | 1 |
| Lichtenstein, P | 1 |
| Oberg, AS | 1 |
| D'Onofrio, BM | 1 |
| de Leão, ERLP | 1 |
| de Souza, DNC | 1 |
| de Moura, LVB | 1 |
| da Silveira Júnior, AM | 1 |
| Dos Santos, ALG | 1 |
| Diniz, DG | 1 |
| Diniz, CWP | 1 |
| Sosthenes, MCK | 1 |
| Farahani, M | 1 |
| Rezaei-Tavirani, M | 1 |
| Zali, A | 1 |
| Zamanian-Azodi, M | 1 |
| Wang, K | 1 |
| Li, N | 1 |
| Xu, M | 1 |
| Huang, M | 1 |
| Huang, F | 2 |
| Yang, JQ | 1 |
| Yang, CH | 1 |
| Pizzamiglio, L | 1 |
| Focchi, E | 1 |
| Cambria, C | 1 |
| Ponzoni, L | 1 |
| Ferrara, S | 1 |
| Bifari, F | 1 |
| Desiato, G | 1 |
| Landsberger, N | 1 |
| Murru, L | 1 |
| Passafaro, M | 1 |
| Sala, M | 1 |
| Matteoli, M | 1 |
| Menna, E | 1 |
| Antonucci, F | 1 |
| Honybun, E | 1 |
| Thwaites, R | 1 |
| Malpas, CB | 1 |
| Rayner, G | 1 |
| Anderson, A | 1 |
| Graham, J | 1 |
| Hitchcock, A | 1 |
| Vajda, FJE | 1 |
| Perucca, P | 1 |
| Che, X | 1 |
| Dai, Y | 2 |
| Xu, Y | 1 |
| Traetta, ME | 2 |
| Codagnone, MG | 2 |
| Uccelli, NA | 2 |
| Ramos, AJ | 1 |
| Zárate, S | 1 |
| Reinés, A | 1 |
| Ryu, YK | 1 |
| Park, HY | 1 |
| Go, J | 1 |
| Choi, DH | 1 |
| Choi, YK | 1 |
| Rhee, M | 1 |
| Lee, CH | 1 |
| Kim, KS | 1 |
| Puig-Lagunes, ÁA | 1 |
| Rocha, L | 1 |
| Morgado-Valle, C | 1 |
| BeltrÁn-Parrazal, L | 1 |
| LÓpez-Meraz, ML | 1 |
| Taleb, A | 1 |
| Lin, W | 1 |
| Xu, X | 2 |
| Zhou, QG | 1 |
| Naveed, M | 1 |
| Fukunaga, K | 1 |
| Han, F | 1 |
| Vangsness, L | 1 |
| Shrestha, TB | 1 |
| Cheng, Q | 1 |
| Zhai, C | 1 |
| Manjeese, W | 1 |
| Mvubu, NE | 1 |
| Steyn, AJC | 1 |
| Mpofana, T | 1 |
| Khodaverdi, M | 1 |
| Tavassoli, Z | 1 |
| Ghasemi, Z | 1 |
| Amini, AE | 1 |
| Pinyue, F | 1 |
| Jing, Z | 1 |
| Wang, W | 1 |
| Tang, J | 1 |
| Zhong, M | 1 |
| Levanovich, N | 1 |
| Rosato Siri, MV | 1 |
| Urrutia, L | 2 |
| Falasco, G | 2 |
| Vázquez, S | 1 |
| Pasquini, JM | 1 |
| Reinés, AG | 1 |
| DeCoteau, WE | 1 |
| Fox, AE | 1 |
| Giona, F | 1 |
| Pagano, J | 1 |
| Verpelli, C | 1 |
| Sala, C | 1 |
| Paz, AVC | 1 |
| Gama, CS | 1 |
| Bambini-Junior, V | 2 |
| Sharma, S | 1 |
| Bansal, S | 1 |
| Kim, HY | 1 |
| Lee, YJ | 1 |
| Kim, SJ | 1 |
| Lee, JD | 1 |
| Kim, KB | 1 |
| Olde Loohuis, NFM | 1 |
| Martens, GJM | 1 |
| van Bokhoven, H | 1 |
| Kaplan, BB | 1 |
| Homberg, JR | 1 |
| Aschrafi, A | 1 |
| Nicolini, C | 1 |
| Fahnestock, M | 1 |
| Acosta, J | 1 |
| Campolongo, MA | 1 |
| Höcht, C | 2 |
| Golombek, DA | 1 |
| Agostino, PV | 1 |
| Stadelmaier, R | 1 |
| Nasri, H | 1 |
| Deutsch, CK | 1 |
| Bauman, M | 1 |
| Hunt, A | 1 |
| Stodgell, CJ | 1 |
| Adams, J | 1 |
| Holmes, LB | 1 |
| Zhou, Y | 1 |
| Peng, L | 1 |
| Kuo, HY | 1 |
| Liu, FC | 1 |
| Kawada, K | 1 |
| Mimori, S | 1 |
| Okuma, Y | 1 |
| Nomura, Y | 1 |
| Chen, W | 1 |
| Chalhub, EG | 1 |
| Barrett, CE | 1 |
| Hennessey, TM | 1 |
| Gordon, KM | 1 |
| Ryan, SJ | 1 |
| McNair, ML | 1 |
| Ressler, KJ | 1 |
| Rainnie, DG | 1 |
| Taruta, A | 1 |
| Kawase, H | 1 |
| Tanabe, W | 1 |
| Tsukada, S | 1 |
| Nakazawa, T | 1 |
| Matsuda, T | 1 |
| Dai, X | 2 |
| Yin, Y | 2 |
| Qin, L | 2 |
| Mahmood, U | 1 |
| Ahn, S | 1 |
| Choi, M | 1 |
| Regan, P | 1 |
| Cho, K | 1 |
| Kumaresan, UD | 1 |
| Kutty, BM | 1 |
| Brown, AR | 1 |
| Teskey, GC | 1 |
| Konopko, MA | 1 |
| Densmore, AL | 1 |
| Krueger, BK | 1 |
| Brumback, AC | 1 |
| Ellwood, IT | 1 |
| Kjaerby, C | 1 |
| Iafrati, J | 1 |
| Robinson, S | 1 |
| Lee, AT | 1 |
| Patel, T | 1 |
| Nagaraj, S | 1 |
| Davatolhagh, F | 1 |
| Sohal, VS | 1 |
| Cartocci, V | 1 |
| Catallo, M | 1 |
| Tempestilli, M | 1 |
| Segatto, M | 1 |
| Pfrieger, FW | 1 |
| Bronzuoli, MR | 1 |
| Scuderi, C | 1 |
| Servadio, M | 1 |
| Pallottini, V | 1 |
| Yasue, M | 1 |
| Kawai, N | 1 |
| Patel, R | 1 |
| Pasos, J | 1 |
| Rosa-Salva, O | 1 |
| Versace, E | 1 |
| Vallortigara, G | 1 |
| Al Sagheer, T | 1 |
| Haida, O | 1 |
| Fernagut, PO | 1 |
| Gonzales, ELT | 2 |
| Kim, DG | 1 |
| Kwon, KJ | 1 |
| Kim, KC | 3 |
| Lee, SH | 1 |
| Salgueiro, N | 1 |
| Chen, YJ | 1 |
| Hsu, YT | 1 |
| Chen, IT | 1 |
| Mangold, S | 1 |
| Chosky, D | 1 |
| Sgritta, M | 1 |
| Dooling, SW | 1 |
| Buffington, SA | 1 |
| Momin, EN | 1 |
| Francis, MB | 1 |
| Britton, RA | 1 |
| Costa-Mattioli, M | 1 |
| Tartaglione, AM | 1 |
| Calamandrei, G | 1 |
| Della-Flora Nunes, G | 1 |
| Souza-Nunes, W | 1 |
| Hirsch, MM | 1 |
| Green, L | 1 |
| Cloarec, R | 1 |
| Riffault, B | 1 |
| Rabiei, H | 1 |
| Guimond, D | 1 |
| Bonifazi, P | 1 |
| Lozovaya, N | 1 |
| Mirza, R | 2 |
| Chen, X | 1 |
| Jiang, X | 1 |
| Niu, J | 1 |
| Cui, C | 1 |
| Chen, Z | 1 |
| Sun, J | 1 |
| Bossu, JL | 1 |
| Mimura, K | 1 |
| Sasaki, T | 1 |
| Sato, C | 1 |
| Suhara, T | 1 |
| Aoki, I | 1 |
| Guimarães-Souza, EM | 1 |
| Joselevitch, C | 1 |
| Britto, LRG | 1 |
| Chiavegatto, S | 1 |
| Eissa, N | 1 |
| Azimullah, S | 1 |
| Jayaprakash, P | 1 |
| Jayaraj, RL | 1 |
| Reiner, D | 1 |
| Ojha, SK | 1 |
| Beiram, R | 1 |
| Stark, H | 1 |
| Łażewska, D | 1 |
| Kieć-Kononowicz, K | 1 |
| Sadek, B | 1 |
| Gentile, S | 1 |
| Moses, L | 1 |
| Katz, N | 1 |
| Weizman, A | 1 |
| Kumar, H | 1 |
| Sharma, BM | 1 |
| Dubiel, A | 2 |
| Nuttall, JR | 1 |
| Castro, K | 1 |
| Baronio, D | 1 |
| Perry, IS | 1 |
| Riesgo, RDS | 1 |
| Banerjee, A | 1 |
| Luong, JA | 1 |
| Ho, A | 1 |
| Saib, AO | 1 |
| Ploski, JE | 1 |
| Cheaha, D | 1 |
| Kumarnsit, E | 1 |
| Zhang, JX | 1 |
| Zhang, QL | 1 |
| Darville, H | 1 |
| Poulet, A | 1 |
| Rodet-Amsellem, F | 1 |
| Chatrousse, L | 1 |
| Pernelle, J | 1 |
| Boissart, C | 1 |
| Héron, D | 1 |
| Nava, C | 1 |
| Perrier, A | 1 |
| Jarrige, M | 1 |
| Cogé, F | 1 |
| Millan, MJ | 1 |
| Bourgeron, T | 1 |
| Peschanski, M | 1 |
| Delorme, R | 1 |
| Benchoua, A | 1 |
| Olexová, L | 1 |
| Štefánik, P | 1 |
| Kršková, L | 1 |
| Peralta, F | 1 |
| Fuentealba, C | 1 |
| Fiedler, J | 1 |
| Aliaga, E | 1 |
| Wei, R | 1 |
| Li, Q | 2 |
| Lam, S | 1 |
| Leung, J | 1 |
| Cheung, C | 1 |
| Sham, PC | 1 |
| Chua, SE | 1 |
| McAlonan, GM | 1 |
| Liu, CX | 1 |
| Peng, XL | 1 |
| Hu, CC | 1 |
| Li, CY | 1 |
| Yang, SM | 2 |
| Han, SH | 2 |
| Banerjee, S | 1 |
| Choi, CS | 1 |
| Mabunga, DF | 1 |
| Bahn, GH | 1 |
| Bertelsen, F | 1 |
| Møller, A | 1 |
| Folloni, D | 1 |
| Drasbek, KR | 1 |
| Scheel-Krüger, J | 1 |
| Landau, AM | 1 |
| Nagode, DA | 1 |
| Meng, X | 1 |
| Winkowski, DE | 1 |
| Smith, E | 1 |
| Khan-Tareen, H | 1 |
| Kareddy, V | 1 |
| Kao, JPY | 1 |
| Kanold, PO | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Lactobacillus Reuteri in Managing Social Deficits in Children With Autistic Spectrum Disorder: a Randomized Clinical Trial With Evaluation of Gut Microbiota and Metabolomics Profiles[NCT04293783] | 43 participants (Actual) | Interventional | 2020-04-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
17 reviews available for valproic acid and Autism Spectrum Disorder
| Article | Year |
|---|---|
Current knowledge, challenges, new perspectives of the study, and treatments of Autism Spectrum Disorder.
Topics: Animals; Antipsychotic Agents; Autism Spectrum Disorder; Disease Models, Animal; Humans; Mice; Oxyto | 2021 |
Epilepsy in Pregnancy-Management Principles and Focus on Valproate.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Autism | 2022 |
Critical Evaluation of Valproic Acid-Induced Rodent Models of Autism: Current and Future Perspectives.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Fema | 2022 |
Psychobehavioural and Cognitive Adverse Events of Anti-Seizure Medications for the Treatment of Developmental and Epileptic Encephalopathies.
Topics: Autism Spectrum Disorder; Bromides; Cannabidiol; Clobazam; Cognition; Ethosuximide; Everolimus; Felb | 2022 |
Sex-Related Changes in the Clinical, Genetic, Electrophysiological, Connectivity, and Molecular Presentations of ASD: A Comparison between Human and Animal Models of ASD with Reference to Our Data.
Topics: Animals; Autism Spectrum Disorder; Brain; Disease Models, Animal; Female; Humans; Male; Mice; S-Aden | 2023 |
[Chronic Activation of the Dopaminergic Neuronal Pathway Improves Behavioral Abnormalities in the Prenatal Valproic Acid Exposure Mouse Model of Autism Spectrum Disorder].
Topics: Animals; Anticonvulsants; Antipsychotic Agents; Autism Spectrum Disorder; Behavior; Disease Models, | 2019 |
Topics: Animals; Autism Spectrum Disorder; Epigenesis, Genetic; Female; Humans; Methionine; Nervous System; | 2020 |
The early overgrowth theory of autism spectrum disorder: Insight into convergent mechanisms from valproic acid exposure and translational models.
Topics: Animals; Autism Spectrum Disorder; Humans; Models, Biological; Translational Research, Biomedical; V | 2020 |
Emerging mechanisms of valproic acid-induced neurotoxic events in autism and its implications for pharmacological treatment.
Topics: Animals; Anticonvulsants; Autism Spectrum Disorder; Female; Humans; Neurotoxicity Syndromes; Pregnan | 2021 |
Valproic Acid and Propionic Acid Modulated Mechanical Pathways Associated with Autism Spectrum Disorder at Prenatal and Neonatal Exposure.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Food Preservati | 2022 |
The valproic acid-induced rodent model of autism.
Topics: Adult; Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Humans; | 2018 |
Prenatal valproate in rodents as a tool to understand the neural underpinnings of social dysfunctions in autism spectrum disorder.
Topics: Animals; Anticonvulsants; Autism Spectrum Disorder; Female; Mice; Pregnancy; Prenatal Exposure Delay | 2019 |
Prevention or Amelioration of Autism-Like Symptoms in Animal Models: Will it Bring Us Closer to Treating Human ASD?
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Fatty Acids, Omega-3; Humans; S-Adenosylm | 2019 |
[The valproate model of autism].
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Disease Models, Animal; Female; Humans; Mice; | 2019 |
Risks of neurobehavioral teratogenicity associated with prenatal exposure to valproate monotherapy: a systematic review with regulatory repercussions.
Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Bipolar Di | 2014 |
The plausibility of maternal toxicant exposure and nutritional status as contributing factors to the risk of autism spectrum disorders.
Topics: Animals; Autism Spectrum Disorder; Benzhydryl Compounds; Brain; Diethylhexyl Phthalate; Disease Mode | 2017 |
Genetic and non-genetic animal models for autism spectrum disorders (ASD).
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Epigenesis, Genetic; Fe | 2016 |
202 other studies available for valproic acid and Autism Spectrum Disorder
| Article | Year |
|---|---|
Cilostazol attenuated prenatal valproic acid-induced behavioural and biochemical deficits in a rat model of autism spectrum disorder.
Topics: Animals; Anticonvulsants; Anxiety; Autism Spectrum Disorder; Behavior, Animal; Biomarkers; Brain; Ci | 2021 |
Prenatal exposure to valproic acid and treatment with intranasal oxytocin have sex-specific effects on behavior in Long Evans rats.
Topics: Administration, Intranasal; Animals; Anti-Anxiety Agents; Anticonvulsants; Autism Spectrum Disorder; | 2021 |
Functional and molecular characterization of a non-human primate model of autism spectrum disorder shows similarity with the human disease.
Topics: Animals; Autism Spectrum Disorder; Callithrix; Dendritic Spines; Disease Models, Animal; Electric St | 2021 |
Brainstem motor neuron dysmorphology and excitatory/inhibitory imbalance in an animal model of autism.
Topics: Animals; Autism Spectrum Disorder; Brain Stem; Disease Models, Animal; Female; Humans; Motor Neurons | 2022 |
Beyond Genes: Germline Disruption in the Etiology of Autism Spectrum Disorders.
Topics: Anesthetics, Inhalation; Autism Spectrum Disorder; Autistic Disorder; Germ Cells; Humans; Valproic A | 2022 |
Duloxetine ameliorates valproic acid-induced hyperactivity, anxiety-like behavior, and social interaction deficits in zebrafish.
Topics: Animals; Anxiety; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Duloxetine Hyd | 2022 |
Assessment of behavioral, morphological and electrophysiological changes in prenatal and postnatal valproate induced rat models of autism spectrum disorder.
Topics: Animals; Anticonvulsants; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Brain; Dise | 2021 |
Effect of Valproic Acid on Maternal - Fetal Heart Rates and Coupling in Mice on Embryonic day 15.5 (E15.5).
Topics: Animals; Autism Spectrum Disorder; Epilepsy; Female; Fetus; Heart Rate, Fetal; Mice; Pregnancy; Valp | 2021 |
Maternal Duplication 15q11-13 Syndrome with Autism Spectrum Disorder: Mood Stabilization by Carbamazepine.
Topics: Anticonvulsants; Antimanic Agents; Autism Spectrum Disorder; Benzodiazepines; Carbamazepine; Humans; | 2022 |
Sex-specific differences in the gut microbiota and fecal metabolites in an adolescent valproic acid-induced rat autism model.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Brain-Gut Axis; Female; Gastrointestinal Micro | 2021 |
Novel role of peroxisome proliferator activated receptor-α in valproic acid rat model of autism: Mechanistic study of risperidone and metformin monotherapy versus combination.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Fema | 2022 |
iTRAQ-Based Proteomics Analysis of Rat Cerebral Cortex Exposed to Valproic Acid before Delivery.
Topics: Animals; Autism Spectrum Disorder; Cerebral Cortex; Disease Models, Animal; Female; Pregnancy; Prena | 2022 |
Early postnatal handling alters social behavior, learning, and memory of pre- and postnatal VPA-induced rat models of autism in a context-based manner.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Fema | 2022 |
Degraded cortical temporal processing in the valproic acid-induced rat model of autism.
Topics: Animals; Auditory Perception; Autism Spectrum Disorder; Autistic Disorder; Disease Models, Animal; N | 2022 |
Alterations of the Hippocampal Networks in Valproic Acid-Induced Rat Autism Model.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Disease Models, Animal; Female; Hippocampus; M | 2022 |
The GABAB receptor agonist STX209 reverses the autism‑like behaviour in an animal model of autism induced by prenatal exposure to valproic acid.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Fema | 2022 |
Postweaning positive modulation of α5GABAA receptors improves autism-like features in prenatal valproate rat model in a sex-specific manner.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Calcium; Disease Models, Ani | 2022 |
Progranulin improves neural development via the PI3K/Akt/GSK-3β pathway in the cerebellum of a VPA-induced rat model of ASD.
Topics: Animals; Autism Spectrum Disorder; Cerebellum; Glycogen Synthase Kinase 3 beta; Phosphatidylinositol | 2022 |
Neuroprotective effect of the standardised extract of Bacopa monnieri (BacoMind) in valproic acid model of autism spectrum disorder in rats.
Topics: Animals; Antioxidants; Autism Spectrum Disorder; Bacopa; Catalase; Disease Models, Animal; Female; H | 2022 |
Human forebrain organoids reveal connections between valproic acid exposure and autism risk.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Chloride Channels; Disease Models, Animal; Hum | 2022 |
Autism-like symptoms by exposure to air pollution and valproic acid-induced in male rats.
Topics: Air Pollutants; Air Pollution; Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Anima | 2022 |
Size anomaly and alteration of GABAergic enzymes expressions in cerebellum of a valproic acid mouse model of autism.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Cerebellum; Disease Models, Animal; Female; ga | 2022 |
Postnatal baicalin ameliorates behavioral and neurochemical alterations in valproic acid-induced rodent model of autism: The possible implication of sirtuin-1/mitofusin-2/ Bcl-2 pathway.
Topics: Animals; Antioxidants; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease Models | 2022 |
Resveratrol Prevents Cytoarchitectural and Interneuronal Alterations in the Valproic Acid Rat Model of Autism.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Disease Models, Animal; Female; Interneurons; | 2022 |
Reinforced behavioral variability in the valproate rat model of autism spectrum disorder.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Female; Humans; Pregnancy; Prenatal Expos | 2022 |
Juvenile handling rescues autism-related effects of prenatal exposure to valproic acid.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Fema | 2022 |
Histamine H3 receptor antagonist, ciproxifan, alleviates cognition and synaptic plasticity alterations in a valproic acid-induced animal model of autism.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Cognition; Disease Models, Animal; Female; His | 2022 |
Vitamin A supplementation ameliorates prenatal valproic acid-induced autism-like behaviors in rats.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Models, Animal; F | 2022 |
Prenatal reduction of E14.5 embryonically fate-mapped pyramidal neurons in a mouse model of autism.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Disease Models, Animal; Female; Humans; Mice; | 2022 |
Association of Prenatal Exposure to Antiseizure Medication With Risk of Autism and Intellectual Disability.
Topics: Anticonvulsants; Autism Spectrum Disorder; Autistic Disorder; Carbamazepine; Child; Cohort Studies; | 2022 |
Prenatal exposure to valproic acid alters Reelin, NGF expressing neuron architecture and impairs social interaction in their autistic-like phenotype male offspring.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Caspase 3; Disease Models, A | 2022 |
LncRNA MEG3 activates CDH2 expression by recruitment of EP300 in valproic acid-induced autism spectrum disorder.
Topics: Animals; Apoptosis; Autism Spectrum Disorder; Cadherins; E1A-Associated p300 Protein; Hippocampus; R | 2022 |
Aberrant induction of p19Arf-mediated cellular senescence contributes to neurodevelopmental defects.
Topics: Animals; Autism Spectrum Disorder; Cellular Senescence; Female; Mice; Microcephaly; Neural Tube Defe | 2022 |
Congenitally underdeveloped intestine drives autism-related gut microbiota and behavior.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Dysbiosis; Gastrointestinal Diseases; Gastroin | 2022 |
Sex difference in cognitive behavioral alterations and barrel cortex neuronal responses in rats exposed prenatally to valproic acid under continuous environmental enrichment.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Cognition; Disease Models, Animal; Female; Huma | 2022 |
Sustained release of sulforaphane by bioactive extracellular vesicles for neuroprotective effect on chick model.
Topics: Animals; Autism Spectrum Disorder; Chick Embryo; Delayed-Action Preparations; Extracellular Vesicles | 2022 |
Modifications of Behavior and Inflammation in Mice Following Transplant with Fecal Microbiota from Children with Autism.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Child; Disease Models, Animal; Female; Humans; | 2022 |
Generational synaptic functions of GABA
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Humans; | 2022 |
Alterations in the intrinsic discharge activity of CA1 pyramidal neurons associated with possible changes in the NADPH diaphorase activity in a rat model of autism induced by prenatal exposure to valproic acid.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Disease Models, Animal; Female; NADPH Dehydrog | 2022 |
A CCR5 antagonist, maraviroc, alleviates neural circuit dysfunction and behavioral disorders induced by prenatal valproate exposure.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Maraviroc; Mice | 2022 |
Autism Spectrum Disorder Model Mice Induced by Prenatal Exposure to Valproic Acid Exhibit Enhanced Empathy-Like Behavior via Oxytocinergic Signaling.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Empathy; Female; Humans | 2022 |
Early-onset of social communication and locomotion activity in F2 pups of a valproic acid-induced mouse model of autism.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Communication; Disease Model | 2022 |
Transcriptomic analysis in the striatum reveals the involvement of Nurr1 in the social behavior of prenatally valproic acid-exposed male mice.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Humans; Male; M | 2022 |
Altered Developmental Trajectory in Male and Female Rats in a Prenatal Valproic Acid Exposure Model of Autism Spectrum Disorder.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Humans; Male; P | 2023 |
Abnormal vestibular brainstem structure and function in an animal model of autism spectrum disorder.
Topics: Animals; Autism Spectrum Disorder; Brain Stem; Calbindins; Disease Models, Animal; Female; Humans; P | 2022 |
Acute rapamycin rescues the hyperexcitable phenotype of accumbal medium spiny neurons in the valproic acid rat model of autism spectrum disorder.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Male; Neurons; | 2022 |
Attenuation of Autism-like Behaviors by an Anthocyanin-Rich Extract from Portuguese Blueberries via Microbiota-Gut-Brain Axis Modulation in a Valproic Acid Mouse Model.
Topics: Animals; Anthocyanins; Autism Spectrum Disorder; Autistic Disorder; Blueberry Plants; Brain-Gut Axis | 2022 |
Prenatal exposure to valproic acid causes allodynia associated with spinal microglial activation.
Topics: Animals; Autism Spectrum Disorder; Calcium; Disease Models, Animal; Female; Humans; Hyperalgesia; Ma | 2022 |
Integrative genomics reveals pathogenic mediator of valproate-induced neurodevelopmental disability.
Topics: Animals; Anticonvulsants; Autism Spectrum Disorder; Epilepsy, Absence; Female; Genomics; Humans; Mal | 2022 |
Homotaurine ameliorates the core ASD symptomatology in VPA rats through GABAergic signaling: Role of GAD67.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; gamma-Aminobuty | 2022 |
Granulocyte Colony-Stimulating Factor Improved Core Symptoms of Autism Spectrum Disorder via Modulating Glutamatergic Receptors in the Prefrontal Cortex and Hippocampus of Rat Brains.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autism Spectrum Disorder; Brain; | 2022 |
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode | 2022 |
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode | 2022 |
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode | 2022 |
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode | 2022 |
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode | 2022 |
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode | 2022 |
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode | 2022 |
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode | 2022 |
Rescue of social deficits by early-life melatonin supplementation through modulation of gut microbiota in a murine model of autism.
Topics: Akkermansia; Animals; Autism Spectrum Disorder; Autistic Disorder; Dietary Supplements; Disease Mode | 2022 |
The State of the Dopaminergic and Glutamatergic Systems in the Valproic Acid Mouse Model of Autism Spectrum Disorder.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Dopamine; Female; Glutamates; Mice; Pregn | 2022 |
The State of the Dopaminergic and Glutamatergic Systems in the Valproic Acid Mouse Model of Autism Spectrum Disorder.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Dopamine; Female; Glutamates; Mice; Pregn | 2022 |
The State of the Dopaminergic and Glutamatergic Systems in the Valproic Acid Mouse Model of Autism Spectrum Disorder.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Dopamine; Female; Glutamates; Mice; Pregn | 2022 |
The State of the Dopaminergic and Glutamatergic Systems in the Valproic Acid Mouse Model of Autism Spectrum Disorder.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Dopamine; Female; Glutamates; Mice; Pregn | 2022 |
The State of the Dopaminergic and Glutamatergic Systems in the Valproic Acid Mouse Model of Autism Spectrum Disorder.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Dopamine; Female; Glutamates; Mice; Pregn | 2022 |
The State of the Dopaminergic and Glutamatergic Systems in the Valproic Acid Mouse Model of Autism Spectrum Disorder.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Dopamine; Female; Glutamates; Mice; Pregn | 2022 |
The State of the Dopaminergic and Glutamatergic Systems in the Valproic Acid Mouse Model of Autism Spectrum Disorder.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Dopamine; Female; Glutamates; Mice; Pregn | 2022 |
The State of the Dopaminergic and Glutamatergic Systems in the Valproic Acid Mouse Model of Autism Spectrum Disorder.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Dopamine; Female; Glutamates; Mice; Pregn | 2022 |
The State of the Dopaminergic and Glutamatergic Systems in the Valproic Acid Mouse Model of Autism Spectrum Disorder.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Dopamine; Female; Glutamates; Mice; Pregn | 2022 |
Glutamatergic synapse in autism: a complex story for a complex disorder.
Topics: Adolescent; Adult; Animals; Autism Spectrum Disorder; Autistic Disorder; Brain; Child; Female; Gluta | 2023 |
Glutamatergic synapse in autism: a complex story for a complex disorder.
Topics: Adolescent; Adult; Animals; Autism Spectrum Disorder; Autistic Disorder; Brain; Child; Female; Gluta | 2023 |
Glutamatergic synapse in autism: a complex story for a complex disorder.
Topics: Adolescent; Adult; Animals; Autism Spectrum Disorder; Autistic Disorder; Brain; Child; Female; Gluta | 2023 |
Glutamatergic synapse in autism: a complex story for a complex disorder.
Topics: Adolescent; Adult; Animals; Autism Spectrum Disorder; Autistic Disorder; Brain; Child; Female; Gluta | 2023 |
Glutamatergic synapse in autism: a complex story for a complex disorder.
Topics: Adolescent; Adult; Animals; Autism Spectrum Disorder; Autistic Disorder; Brain; Child; Female; Gluta | 2023 |
Glutamatergic synapse in autism: a complex story for a complex disorder.
Topics: Adolescent; Adult; Animals; Autism Spectrum Disorder; Autistic Disorder; Brain; Child; Female; Gluta | 2023 |
Glutamatergic synapse in autism: a complex story for a complex disorder.
Topics: Adolescent; Adult; Animals; Autism Spectrum Disorder; Autistic Disorder; Brain; Child; Female; Gluta | 2023 |
Glutamatergic synapse in autism: a complex story for a complex disorder.
Topics: Adolescent; Adult; Animals; Autism Spectrum Disorder; Autistic Disorder; Brain; Child; Female; Gluta | 2023 |
Glutamatergic synapse in autism: a complex story for a complex disorder.
Topics: Adolescent; Adult; Animals; Autism Spectrum Disorder; Autistic Disorder; Brain; Child; Female; Gluta | 2023 |
Modulation of human endogenous retroviruses and cytokines expression in peripheral blood mononuclear cells from autistic children and their parents.
Topics: Autism Spectrum Disorder; Autistic Disorder; Child; Cytokines; Endogenous Retroviruses; Humans; Inte | 2022 |
Modulation of human endogenous retroviruses and cytokines expression in peripheral blood mononuclear cells from autistic children and their parents.
Topics: Autism Spectrum Disorder; Autistic Disorder; Child; Cytokines; Endogenous Retroviruses; Humans; Inte | 2022 |
Modulation of human endogenous retroviruses and cytokines expression in peripheral blood mononuclear cells from autistic children and their parents.
Topics: Autism Spectrum Disorder; Autistic Disorder; Child; Cytokines; Endogenous Retroviruses; Humans; Inte | 2022 |
Modulation of human endogenous retroviruses and cytokines expression in peripheral blood mononuclear cells from autistic children and their parents.
Topics: Autism Spectrum Disorder; Autistic Disorder; Child; Cytokines; Endogenous Retroviruses; Humans; Inte | 2022 |
Continuous high-frequency deep brain stimulation of the anterior insula modulates autism-like behavior in a valproic acid-induced rat model.
Topics: Animals; Autism Spectrum Disorder; Deep Brain Stimulation; Proteomics; Rats; Valproic Acid | 2022 |
Continuous high-frequency deep brain stimulation of the anterior insula modulates autism-like behavior in a valproic acid-induced rat model.
Topics: Animals; Autism Spectrum Disorder; Deep Brain Stimulation; Proteomics; Rats; Valproic Acid | 2022 |
Continuous high-frequency deep brain stimulation of the anterior insula modulates autism-like behavior in a valproic acid-induced rat model.
Topics: Animals; Autism Spectrum Disorder; Deep Brain Stimulation; Proteomics; Rats; Valproic Acid | 2022 |
Continuous high-frequency deep brain stimulation of the anterior insula modulates autism-like behavior in a valproic acid-induced rat model.
Topics: Animals; Autism Spectrum Disorder; Deep Brain Stimulation; Proteomics; Rats; Valproic Acid | 2022 |
GABAergic synaptic transmission and cortical oscillation patterns in the primary somatosensory area of a valproic acid rat model of autism spectrum disorder.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Pregnancy; Pren | 2023 |
GABAergic synaptic transmission and cortical oscillation patterns in the primary somatosensory area of a valproic acid rat model of autism spectrum disorder.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Pregnancy; Pren | 2023 |
GABAergic synaptic transmission and cortical oscillation patterns in the primary somatosensory area of a valproic acid rat model of autism spectrum disorder.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Pregnancy; Pren | 2023 |
GABAergic synaptic transmission and cortical oscillation patterns in the primary somatosensory area of a valproic acid rat model of autism spectrum disorder.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Pregnancy; Pren | 2023 |
Adolescent female valproic acid rats have impaired extra-dimensional shifts of attention and enlarged anterior cingulate cortices.
Topics: Adolescent; Animals; Attention; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; | 2023 |
Adolescent female valproic acid rats have impaired extra-dimensional shifts of attention and enlarged anterior cingulate cortices.
Topics: Adolescent; Animals; Attention; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; | 2023 |
Adolescent female valproic acid rats have impaired extra-dimensional shifts of attention and enlarged anterior cingulate cortices.
Topics: Adolescent; Animals; Attention; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; | 2023 |
Adolescent female valproic acid rats have impaired extra-dimensional shifts of attention and enlarged anterior cingulate cortices.
Topics: Adolescent; Animals; Attention; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; | 2023 |
Lutein-loaded nanoparticles reverse oxidative stress, apoptosis, and autism spectrum disorder-like behaviors induced by prenatal valproic acid exposure in female rats.
Topics: Animals; Apoptosis; Autism Spectrum Disorder; Biomarkers; Female; Humans; Lutein; Nanoparticles; Oxi | 2023 |
Lutein-loaded nanoparticles reverse oxidative stress, apoptosis, and autism spectrum disorder-like behaviors induced by prenatal valproic acid exposure in female rats.
Topics: Animals; Apoptosis; Autism Spectrum Disorder; Biomarkers; Female; Humans; Lutein; Nanoparticles; Oxi | 2023 |
Lutein-loaded nanoparticles reverse oxidative stress, apoptosis, and autism spectrum disorder-like behaviors induced by prenatal valproic acid exposure in female rats.
Topics: Animals; Apoptosis; Autism Spectrum Disorder; Biomarkers; Female; Humans; Lutein; Nanoparticles; Oxi | 2023 |
Lutein-loaded nanoparticles reverse oxidative stress, apoptosis, and autism spectrum disorder-like behaviors induced by prenatal valproic acid exposure in female rats.
Topics: Animals; Apoptosis; Autism Spectrum Disorder; Biomarkers; Female; Humans; Lutein; Nanoparticles; Oxi | 2023 |
Effects of different doses of lithium on the central nervous system in the rat valproic acid model of autism.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Hippocampus; Lithium; Lithium Compounds; Rats; | 2023 |
Valproic acid affects neurogenesis during early optic tectum development in zebrafish.
Topics: Animals; Autism Spectrum Disorder; Humans; Mammals; Neurogenesis; Superior Colliculi; Valproic Acid; | 2023 |
Photobiomodulation Attenuated Cognitive Dysfunction and Neuroinflammation in a Prenatal Valproic Acid-Induced Autism Spectrum Disorder Mouse Model.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Cognitive Dysfunction; Disease Models, Animal; | 2022 |
The interaction between intestinal bacterial metabolites and phosphatase and tensin homolog in autism spectrum disorder.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Inflammation; Mice; PTEN Phosphohydrolase | 2023 |
Dysregulation of the chromatin environment leads to differential alternative splicing as a mechanism of disease in a human model of autism spectrum disorder.
Topics: Alternative Splicing; Animals; Autism Spectrum Disorder; Child; Chromatin; Disease Models, Animal; F | 2023 |
Fecal microbiota transplantation improves VPA-induced ASD mice by modulating the serotonergic and glutamatergic synapse signaling pathways.
Topics: Animals; Autism Spectrum Disorder; Dysbiosis; Fecal Microbiota Transplantation; Mice; Signal Transdu | 2023 |
Thymol improves autism-like behaviour in VPA-induced ASD rats through the Pin1/p38 MAPK pathway.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Disease Models, Animal; Female; Humans; Inflam | 2023 |
Maternal treatment with aripiprazole prevents the development of a valproic acid-induced autism-like phenotype in juvenile male mice.
Topics: Animals; Anticonvulsants; Aripiprazole; Autism Spectrum Disorder; Behavior, Animal; Disease Models, | 2023 |
Prenatally VPA exposure is likely to cause autistic-like behavior in the rats offspring via TREM2 down-regulation to affect the microglial activation and synapse alterations.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Down | 2023 |
Memantine/Aripiprazole Combination Alleviates Cognitive Dysfunction in Valproic Acid Rat Model of Autism: Hippocampal CREB/BDNF Signaling and Glutamate Homeostasis.
Topics: Animals; Aripiprazole; Autism Spectrum Disorder; Autistic Disorder; Brain-Derived Neurotrophic Facto | 2023 |
Retinoic acid administration normalizes aberrant microglial activation via regulating TREM2 transcription in the PFC of valproic acid induced autism rat.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Microglia; Prefrontal Cortex; Rats; Retinoic A | 2023 |
Ameliorating age-dependent effects of resveratrol on VPA-induced social impairments and anxiety-like behaviors in a rat model of neurodevelopmental disorder.
Topics: Animals; Anxiety; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Humans | 2023 |
Fetal exposure to valproic acid dysregulates the expression of autism-linked genes in the developing cerebellum.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Brain; Cerebellum; Mice; Valproic Acid | 2023 |
Neonatal Exposure to Valproate Induces Long-Term Alterations in Steroid Hormone Levels in the Brain Cortex of Prepubertal Rats.
Topics: Animals; Autism Spectrum Disorder; Brain; Cerebral Cortex; Disease Models, Animal; Estradiol; Female | 2023 |
Alteration in social interaction and tactile discrimination of juvenile autistic-like rats following tactile stimulation and whisker deprivation.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Female; Male; Pregnancy; Rats; Social Interact | 2023 |
Effects of varied‑intensity endurance exercise training on oxidative and antioxidant factors in the liver of rats with valproic acid‑induced autism.
Topics: Animals; Antioxidants; Autism Spectrum Disorder; Autistic Disorder; Catalase; Female; Humans; Liver; | 2023 |
GM1 Reduced the Symptoms of Autism Spectrum Disorder by Suppressing α-Syn Through Activating Autophagy.
Topics: Animals; Autism Spectrum Disorder; Autophagy; Disease Models, Animal; Female; G(M1) Ganglioside; Hum | 2023 |
Decreased Expression of EP3 Receptor mRNA in the Brain of Mouse Model of Autism Spectrum Disorder.
Topics: Animals; Autism Spectrum Disorder; Brain; Disease Models, Animal; Female; Mice; MicroRNAs; Neuroinfl | 2023 |
The comparative effectiveness of metformin and risperidone in a rat model of valproic acid-induced autism, Potential role for enhanced autophagy.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Autophagy; Disease Models, Animal; Female; Hum | 2023 |
Chronic acetyl-L-carnitine treatment alleviates behavioral deficits and neuroinflammation through enhancing microbiota derived-SCFA in valproate model of autism.
Topics: Acetylcarnitine; Animals; Autism Spectrum Disorder; Autistic Disorder; Encephalitis; Female; Microbi | 2023 |
Amelioration of cognition impairments in the valproic acid-induced animal model of autism by ciproxifan, a histamine H3-receptor antagonist.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Cognition; Cognitive Dysfunc | 2023 |
Valproate-induced murine autism spectrum disorder is associated with dysfunction of amygdala parvalbumin interneurons and downregulation of AMPK/SIRT1/PGC1α signaling.
Topics: AMP-Activated Protein Kinases; Amygdala; Animals; Autism Spectrum Disorder; Behavior, Animal; Caspas | 2023 |
Social deficits in mice prenatally exposed to valproic acid are intergenerationally inherited and rescued by social enrichment.
Topics: Animals; Anticonvulsants; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female | 2023 |
Music alleviates cognitive impairments in an animal model of autism.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Cognitive Dysfunction; Disea | 2023 |
Retinoic acid supplementation ameliorates motor incoordination via RARα-CBLN2 in the cerebellum of a prenatal valproic acid-exposed rat autism model.
Topics: Animals; Ataxia; Autism Spectrum Disorder; Autistic Disorder; Cerebellum; Dietary Supplements; Disea | 2023 |
Mouse nerve growth factor suppresses neuronal apoptosis in valproic acid-induced autism spectrum disorder rats by regulating the phosphoinositide-3-kinase/serine/threonine kinase signaling pathway.
Topics: Animals; Apoptosis; Autism Spectrum Disorder; Disease Models, Animal; Humans; Mice; Phosphatidylinos | 2023 |
Abnormal auditory brainstem responses in an animal model of autism spectrum disorder.
Topics: Animals; Auditory Pathways; Auditory Threshold; Autism Spectrum Disorder; Brain Stem; Disease Models | 2023 |
Phosphodiesterase inhibitor, ibudilast alleviates core behavioral and biochemical deficits in the prenatal valproic acid exposure model of autism spectrum disorder.
Topics: Animals; Anxiety; Autism Spectrum Disorder; Disease Models, Animal; Female; Inflammation Mediators; | 2023 |
Adolescent swimming exercise following maternal valproic acid treatment improves cognition and reduces stress-related symptoms in offspring mice: Role of sex and brain cytokines.
Topics: Anhedonia; Animals; Autism Spectrum Disorder; Behavior, Animal; Brain; Cognition; Cytokines; Disease | 2023 |
Striatal synaptic changes and behavior in adult mouse upon prenatal exposure to valproic acid.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Fema | 2023 |
G protein-coupled estrogen receptor (GPER) selective agonist G1 attenuates the neurobehavioral, molecular and biochemical alterations induced in a valproic acid rat model of autism.
Topics: Animals; Aromatase; Autism Spectrum Disorder; Autistic Disorder; Disease Models, Animal; Estradiol; | 2023 |
Syringic acid alleviates valproic acid induced autism via activation of p38 mitogen-activated protein kinase: Possible molecular approach.
Topics: Animals; Antioxidants; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease Models | 2023 |
Chronic inhibition of astrocytic aquaporin-4 induces autistic-like behavior in control rat offspring similar to maternal exposure to valproic acid.
Topics: Animals; Aquaporins; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease Models, | 2023 |
Mice prenatally exposed to valproic acid do not show autism-related disorders when fed with polyunsaturated fatty acid-enriched diets.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Diet; Dietary Supplements; Fatty Acids, Omega- | 2023 |
Risperidone impedes glutamate excitotoxicity in a valproic acid rat model of autism: Role of ADAR2 in AMPA GluA2 RNA editing.
Topics: Adenosine Deaminase; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autism Spect | 2023 |
The antipsychotic olanzapine reduces memory deficits and neuronal abnormalities in a male rat model of Autism.
Topics: Animals; Antipsychotic Agents; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Diseas | 2023 |
Toxicity and teratogenicity effects of valproic acid on zebrafish (Danio rerio) embryos in relation to autism spectrum disorder.
Topics: Animals; Anticonvulsants; Autism Spectrum Disorder; Behavior, Animal; Teratogenesis; Teratogens; Val | 2023 |
Dysregulation of the Wnt/β-catenin signaling pathway via Rnf146 upregulation in a VPA-induced mouse model of autism spectrum disorder.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Female; Mice; Pregnancy; Proteomics; Ubiq | 2023 |
The Notch1/Hes1 signaling pathway affects autophagy by adjusting DNA methyltransferases expression in a valproic acid-induced autism spectrum disorder model.
Topics: Animals; Autism Spectrum Disorder; Autophagy; DNA; DNA Methylation; DNA Modification Methylases; Rat | 2023 |
Prangos ferulacea (L.) ameliorates behavioral alterations, hippocampal oxidative stress markers, and apoptotic deficits in a rat model of autism induced by valproic acid.
Topics: Animals; Antioxidants; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Child; Disease | 2023 |
Group I and group II metabotropic glutamate receptors are upregulated in the synapses of infant rats prenatally exposed to valproic acid.
Topics: Adolescent; Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Hum | 2023 |
Exposure to nonylphenol in early life causes behavioural deficits related with autism spectrum disorders in rats.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Female; Humans; Neurons; Phenols; Prenata | 2023 |
Modulation of PI3K/Akt/GSK3β signaling cascade through G protein-coupled receptor 55 (GPR55) activation: Prenatal lysophosphatidylinositol attenuates valproic acid-induced synaptic abnormalities and mitochondrial dysfunction.
Topics: Autism Spectrum Disorder; Glycogen Synthase Kinase 3 beta; Humans; Lysophospholipids; Phosphatidylin | 2023 |
MA-5 ameliorates autism-like behavior in mice prenatally exposed to valproic acid.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Fema | 2023 |
"Comparative evaluation of different chemical agents induced Autism Spectrum Disorder in experimental Wistar rats".
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Chlorpyrifos; Cytokines; Dioxins; Disease Model | 2024 |
The effects of valproic acid neurotoxicity on aggressive behavior in zebrafish autism model.
Topics: Aggression; Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease Models, | 2024 |
Gene-environment interaction counterbalances social impairment in mouse models of autism.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Excitatory Postsynaptic Potentials; Femal | 2019 |
Targeting the inhibition of fatty acid amide hydrolase ameliorate the endocannabinoid-mediated synaptic dysfunction in a valproic acid-induced rat model of Autism.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Autism Spectrum Disorder; Benzamides; Carbamates; Disea | 2020 |
Prenatal exposure to valproic acid is associated with altered neurocognitive function and neurogenesis in the dentate gyrus of male offspring rats.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Behavior, Animal; | 2019 |
Sex-specific effects of prenatal valproic acid exposure on sociability and neuroinflammation: Relevance for susceptibility and resilience in autism.
Topics: Animals; Animals, Outbred Strains; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Anima | 2019 |
Improvement of autistic-like behaviors in adult rats prenatally exposed to valproic acid through early suppression of NMDA receptor function.
Topics: Animals; Autism Spectrum Disorder; Brain; Disease Models, Animal; Dizocilpine Maleate; Excitatory Am | 2020 |
Maternal valproic acid exposure leads to neurogenesis defects and autism-like behaviors in non-human primates.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Disease Susceptibility; | 2019 |
In utero exposure to valproic acid disrupts ascending projections to the central nucleus of the inferior colliculus from the auditory brainstem.
Topics: Animals; Auditory Pathways; Autism Spectrum Disorder; Brain Stem; Disease Models, Animal; Female; In | 2020 |
Long-lasting Behavioral and Neuroanatomical Effects of Postnatal Valproic Acid Treatment.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Female; Male; Mice; Pregnancy; Prenatal E | 2020 |
Oxytocin ameliorates maternal separation-induced ultrasonic vocalisation calls in mouse pups prenatally exposed to valproic acid.
Topics: ADP-ribosyl Cyclase 1; Animals; Autism Spectrum Disorder; Disease Models, Animal; Female; Maternal D | 2020 |
Prenatal S-Adenosine Methionine (SAMe) Induces Changes in Gene Expression in the Brain of Newborn Mice That Are Prevented by Co-Administration of Valproic Acid (VPA).
Topics: Animals; Animals, Newborn; Autism Spectrum Disorder; Brain; Epigenesis, Genetic; Female; Gene Expres | 2020 |
Novel potential of metformin on valproic acid-induced autism spectrum disorder in rats: involvement of antioxidant defence system.
Topics: Animals; Anticonvulsants; Antioxidants; Autism Spectrum Disorder; Disease Models, Animal; Female; Hy | 2020 |
Prenatal Exposure to Valproic Acid Affects Microglia and Synaptic Ultrastructure in a Brain-Region-Specific Manner in Young-Adult Male Rats: Relevance to Autism Spectrum Disorders.
Topics: Animals; Anticonvulsants; Autism Spectrum Disorder; Behavior, Animal; Brain; Female; Inflammation; M | 2020 |
Inhibition of striatal-enriched protein tyrosine phosphatase (STEP) activity reverses behavioral deficits in a rodent model of autism.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Expl | 2020 |
A heritable profile of six miRNAs in autistic patients and mouse models.
Topics: Adolescent; Adult; Animals; Anxiety; Autism Spectrum Disorder; Autistic Disorder; Child; Child, Pres | 2020 |
Effects of prenatal exposure to valproic acid or poly(I:C) on ultrasonic vocalizations in rat pups: The role of social cues.
Topics: Animals; Autism Spectrum Disorder; Cues; Female; Male; Pregnancy; Prenatal Exposure Delayed Effects; | 2020 |
Abnormal reinforcement learning in a mice model of autism induced by prenatal exposure to valproic acid.
Topics: Animals; Autism Spectrum Disorder; Conditioning, Psychological; Disease Models, Animal; Female; Lear | 2020 |
Implementation of a six-around-one optical probe based on diffuse light spectroscopy for study of cerebral properties in a murine mouse model of autism spectrum disorder.
Topics: Algorithms; Animals; Anticonvulsants; Autism Spectrum Disorder; Brain; Disease Models, Animal; Femal | 2020 |
Similarities between the Effects of Prenatal Chlorpyrifos and Valproic Acid on Ultrasonic Vocalization in Infant Wistar Rats.
Topics: Animals; Autism Spectrum Disorder; Chlorpyrifos; Disease Models, Animal; Enzyme Inhibitors; Female; | 2020 |
Micromolar Valproic Acid Doses Preserve Survival and Induce Molecular Alterations in Neurodevelopmental Genes in Two Strains of Zebrafish Larvae.
Topics: Animals; Anticonvulsants; Anxiety; Autism Spectrum Disorder; Disease Models, Animal; Female; Larva; | 2020 |
Valproic acid treated female Long-Evans rats are impaired on attentional set-shifting.
Topics: Animals; Attention; Autism Spectrum Disorder; Behavior, Animal; Cognitive Dysfunction; Disease Model | 2021 |
Antiseizure medication use during pregnancy and risk of ASD and ADHD in children.
Topics: Adolescent; Adult; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Autism Spectrum D | 2020 |
Attenuation of neurobehavioural abnormalities by papaverine in prenatal valproic acid rat model of ASD.
Topics: Animals; Anticonvulsants; Autism Spectrum Disorder; Dose-Response Relationship, Drug; Doublecortin P | 2021 |
Lateral septum microglial changes and behavioral abnormalities of mice exposed to valproic acid during the prenatal period.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; GABA Agents; Mi | 2021 |
Systematic Analysis of Protein-Protein and Gene-Environment Interactions to Decipher the Cognitive Mechanisms of Autism Spectrum Disorder.
Topics: Autism Spectrum Disorder; Autistic Disorder; Cognition; Gene-Environment Interaction; Humans; Valpro | 2022 |
Glyoxalase 1 Inhibitor Alleviates Autism-like Phenotype in a Prenatal Valproic Acid-Induced Mouse Model.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Fema | 2020 |
Combined the GABA-A and GABA-B receptor agonists attenuates autistic behaviors in a prenatal valproic acid-induced mouse model of autism.
Topics: Animals; Anticonvulsants; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Drug T | 2021 |
The DNA repair protein ATM as a target in autism spectrum disorder.
Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Autism Spectrum Disorder; Behavior, Animal; Disease | 2021 |
Prenatal valproate exposure and adverse neurodevelopmental outcomes: Does sex matter?
Topics: Anticonvulsants; Autism Spectrum Disorder; Case-Control Studies; Child; Child, Preschool; Dose-Respo | 2021 |
Perinatal exposure to BDE-47 exacerbated autistic-like behaviors and impairments of dendritic development in a valproic acid-induced rat model of autism.
Topics: Animals; Animals, Newborn; Autism Spectrum Disorder; Dendrites; Disease Models, Animal; Environmenta | 2021 |
Hippocampal neurons isolated from rats subjected to the valproic acid model mimic in vivo synaptic pattern: evidence of neuronal priming during early development in autism spectrum disorders.
Topics: Animals; Anticonvulsants; Autism Spectrum Disorder; Behavior, Animal; Cells, Cultured; Disease Model | 2021 |
Sodium phenylbutyrate reduces repetitive self-grooming behavior and rescues social and cognitive deficits in mouse models of autism.
Topics: Animals; Antineoplastic Agents; Autism Spectrum Disorder; Brain; Cognitive Dysfunction; Disease Mode | 2021 |
Brain and plasma amino acid concentration in infant rats prenatally exposed to valproic acid.
Topics: Amino Acids; Animals; Autism Spectrum Disorder; Brain; Female; Male; Plasma; Pregnancy; Prenatal Exp | 2021 |
Increased volumes of lobule VI in a valproic acid model of autism are associated with worse set-shifting performance in male Long-Evan rats.
Topics: Animals; Attention; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Brain; Cerebellum | 2021 |
Maternal folic acid supplementation prevents autistic behaviors in a rat model induced by prenatal exposure to valproic acid.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Dietary Supplements; Disease | 2021 |
Mycobacterium tuberculosis causes a leaky blood-brain barrier and neuroinflammation in the prefrontal cortex and cerebellum regions of infected mice offspring.
Topics: Adult; Animals; Astrocytes; Autism Spectrum Disorder; Blood-Brain Barrier; Cell Count; Cerebellum; F | 2021 |
5-HT7 receptor activation rescues impaired synaptic plasticity in an autistic-like rat model induced by prenatal VPA exposure.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; CA1 Region, Hippocampal; Disease Models, Animal | 2021 |
Oxytocin administration modulates the complex type of ultrasonic vocalisation of mice pups prenatally exposed to valproic acid.
Topics: Animals; Autism Spectrum Disorder; Communication; Disease Models, Animal; Female; Humans; Male; Mate | 2021 |
HIF-1 α may play a role in late pregnancy hypoxia-induced autism-like behaviors in offspring rats.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Female; Hypoxia; Hypoxia-Inducible Factor | 2021 |
Neurobiological substrates underlying corpus callosum hypoconnectivity and brain metabolic patterns in the valproic acid rat model of autism spectrum disorder.
Topics: Animals; Autism Spectrum Disorder; Brain; Corpus Callosum; Exploratory Behavior; Female; Male; Nerve | 2021 |
Timing and Intertemporal Choice Behavior in the Valproic Acid Rat Model of Autism Spectrum Disorder.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Choice Behavior; Disease Models, Animal; Female | 2022 |
Abnormal spatiotemporal expression pattern of progranulin and neurodevelopment impairment in VPA-induced ASD rat model.
Topics: Animals; Anticonvulsants; Apoptosis; Autism Spectrum Disorder; Behavior, Animal; Brain; Disease Mode | 2021 |
Another step toward understanding brain functional connectivity alterations in autism: An Editorial Highlight for "Neurobiological substrates underlying corpus callosum hypoconnectivity and brain metabolic patterns in the valproic acid rat model of autism
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Brain; Corpus Callosum; Humans; Nerve Net; Rat | 2021 |
Resveratrol prevents long-term structural hippocampal alterations and modulates interneuron organization in an animal model of ASD.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Hippocampus; In | 2021 |
Vinpocetine amended prenatal valproic acid induced features of ASD possibly by altering markers of neuronal function, inflammation, and oxidative stress.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Biomarkers; Disease Models, Animal; Doublecorti | 2021 |
Metabolomics profiling of valproic acid-induced symptoms resembling autism spectrum disorders using 1H NMR spectral analysis in rat model.
Topics: Animals; Autism Spectrum Disorder; Biomarkers; Brain; Disease Models, Animal; Female; Male; Maternal | 2022 |
Altered expression of circadian rhythm and extracellular matrix genes in the medial prefrontal cortex of a valproic acid rat model of autism.
Topics: Animals; Autism Spectrum Disorder; Circadian Rhythm; Disease Models, Animal; Extracellular Matrix; F | 2017 |
Deficits in temporal processing in mice prenatally exposed to Valproic Acid.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Dopamine; Female; GABA | 2018 |
Exposure to Sodium Valproate during Pregnancy: Facial Features and Signs of Autism.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Autism Spectrum Disorder; Autistic | 2017 |
Reduced protein expressions of cytomembrane GABA
Topics: Animals; Autism Spectrum Disorder; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; | 2017 |
Valproic acid induces aberrant development of striatal compartments and corticostriatal pathways in a mouse model of autism spectrum disorder.
Topics: Animals; Autism Spectrum Disorder; Bromodeoxyuridine; Corpus Striatum; Disease Models, Animal; Femal | 2017 |
Involvement of endoplasmic reticulum stress and neurite outgrowth in the model mice of autism spectrum disorder.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Endoplasmic Reticulum Stress; Hippocampus | 2018 |
Inattention and Poor Eye Contact Is Not All Autism.
Topics: Anticonvulsants; Autism Spectrum Disorder; Child; Diagnosis, Differential; Electroencephalography; E | 2017 |
Developmental disruption of amygdala transcriptome and socioemotional behavior in rats exposed to valproic acid prenatally.
Topics: Amygdala; Animals; Autism Spectrum Disorder; Behavior, Animal; Emotions; Female; Humans; Male; Pregn | 2017 |
Risperidone and aripiprazole alleviate prenatal valproic acid-induced abnormalities in behaviors and dendritic spine density in mice.
Topics: Animals; Aripiprazole; Autism Spectrum Disorder; Dendritic Spines; Disease Models, Animal; Dopamine; | 2017 |
Valproic acid exposure decreases the mRNA stability of Bcl-2 via up-regulating miR-34a in the cerebellum of rat.
Topics: Animals; Anticonvulsants; Autism Spectrum Disorder; Behavior, Animal; Cell Line; Cerebellar Cortex; | 2017 |
Dendritic spine anomalies and PTEN alterations in a mouse model of VPA-induced autism spectrum disorder.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Cerebral Cortex; Dendritic Spines; Disease Mode | 2018 |
Altered attentional processing in male and female rats in a prenatal valproic acid exposure model of autism spectrum disorder.
Topics: Animals; Attention; Autism Spectrum Disorder; Disease Models, Animal; Female; Male; Pregnancy; Prena | 2017 |
Motivational wheel running reverses cueing behavioural inflexibility in rodents.
Topics: Acoustic Stimulation; Animals; Association Learning; Autism Spectrum Disorder; Cues; Disease Models, | 2017 |
Sexually Dimorphic Epigenetic Regulation of Brain-Derived Neurotrophic Factor in Fetal Brain in the Valproic Acid Model of Autism Spectrum Disorder.
Topics: Animals; Autism Spectrum Disorder; Brain; Brain-Derived Neurotrophic Factor; Chromatin Immunoprecipi | 2017 |
Identifying specific prefrontal neurons that contribute to autism-associated abnormalities in physiology and social behavior.
Topics: Action Potentials; Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease M | 2018 |
Altered Brain Cholesterol/Isoprenoid Metabolism in a Rat Model of Autism Spectrum Disorders.
Topics: Adenylate Kinase; Animals; Autism Spectrum Disorder; Brain; Cholesterol; Disease Models, Animal; Fem | 2018 |
Inequity aversion is observed in common marmosets but not in marmoset models of autism induced by prenatal exposure to valproic acid.
Topics: Animals; Autism Spectrum Disorder; Callithrix; Disease Models, Animal; Feeding Behavior; Female; Mal | 2018 |
Repeated Prenatal Exposure to Valproic Acid Results in Auditory Brainstem Hypoplasia and Reduced Calcium Binding Protein Immunolabeling.
Topics: Animals; Anticonvulsants; Auditory Pathways; Autism Spectrum Disorder; Brain Stem; Calcium-Binding P | 2018 |
Embryonic Exposure to Valproic Acid Impairs Social Predispositions of Newly-Hatched Chicks.
Topics: Animals; Anticonvulsants; Autism Spectrum Disorder; Chickens; Disease Models, Animal; Embryonic Deve | 2018 |
Motor Impairments Correlate with Social Deficits and Restricted Neuronal Loss in an Environmental Model of Autism.
Topics: Animals; Autism Spectrum Disorder; Brain; Disease Models, Animal; Female; Gait; Male; Mice, Inbred C | 2018 |
Pharmacological modulation of AMPA receptor rescues social impairments in animal models of autism.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Brain; Disease Models, Animal; Excitatory Amino | 2019 |
Sociability deficits after prenatal exposure to valproic acid are rescued by early social enrichment.
Topics: Animals; Autism Spectrum Disorder; Brain; Female; Male; Mice; Pregnancy; Prenatal Exposure Delayed E | 2018 |
Deep Brain Stimulation Modified Autism-Like Deficits via the Serotonin System in a Valproic Acid-Induced Rat Model.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autism Spectrum Disorder; Deep Brain Stimulation; M | 2018 |
Auditory Midbrain Hypoplasia and Dysmorphology after Prenatal Valproic Acid Exposure.
Topics: Animals; Auditory Pathways; Autism Spectrum Disorder; Calbindins; Cell Count; Dopaminergic Neurons; | 2019 |
Mechanisms Underlying Microbial-Mediated Changes in Social Behavior in Mouse Models of Autism Spectrum Disorder.
Topics: Action Potentials; Animals; Autism Spectrum Disorder; Benzoxazines; Capillary Permeability; Central | 2019 |
Hyperexcitability of hippocampal CA1 pyramidal neurons in male offspring of a rat model of autism spectrum disorder (ASD) induced by prenatal exposure to valproic acid: A possible involvement of Ih channel current.
Topics: Action Potentials; Animals; Autism Spectrum Disorder; CA1 Region, Hippocampal; Disease Models, Anima | 2019 |
Abnormal empathy-like pro-social behaviour in the valproic acid model of autism spectrum disorder.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Empathy; Female; Interpersonal Relations; | 2019 |
Pyramidal neuron growth and increased hippocampal volume during labor and birth in autism.
Topics: Animals; Animals, Newborn; Autism Spectrum Disorder; Bumetanide; Dendrites; Disease Models, Animal; | 2019 |
Benefits of Fenofibrate in prenatal valproic acid-induced autism spectrum disorder related phenotype in rats.
Topics: Animals; Anticonvulsants; Anxiety; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Br | 2019 |
Betaine ameliorates prenatal valproic-acid-induced autism-like behavioral abnormalities in mice by promoting homocysteine metabolism.
Topics: Animals; Antimanic Agents; Autism Spectrum Disorder; Behavior, Animal; Betaine; Disease Models, Anim | 2019 |
Abnormal axon guidance signals and reduced interhemispheric connection via anterior commissure in neonates of marmoset ASD model.
Topics: Animals; Animals, Newborn; Anterior Commissure, Brain; Autism Spectrum Disorder; Axon Guidance; Call | 2019 |
Retinal alterations in a pre-clinical model of an autism spectrum disorder.
Topics: Action Potentials; Animals; Autism Spectrum Disorder; Endophenotypes; Female; Fragile X Mental Retar | 2019 |
Beneficial effects of pioglitazone, a selective peroxisome proliferator-activated receptor-γ agonist in prenatal valproic acid-induced behavioral and biochemical autistic like features in Wistar rats.
Topics: Animals; Anticonvulsants; Anxiety; Autism Spectrum Disorder; Brain Chemistry; Cytokines; Exploratory | 2019 |
The dual-active histamine H3 receptor antagonist and acetylcholine esterase inhibitor E100 ameliorates stereotyped repetitive behavior and neuroinflammmation in sodium valproate induced autism in mice.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Cholinesterase Inhibitors; Cytokines; Disease M | 2019 |
Impact of epilepsy and antiepileptic medications on the metabolic profile in adults with autism spectrum disorder and intellectual disabilities.
Topics: Adult; Anticonvulsants; Autism Spectrum Disorder; Blood Glucose; Body Mass Index; Carbamazepine; Cho | 2015 |
Benefits of agomelatine in behavioral, neurochemical and blood brain barrier alterations in prenatal valproic acid induced autism spectrum disorder.
Topics: Acetamides; Animals; Anticonvulsants; Autism Spectrum Disorder; Blood-Brain Barrier; Exploratory Beh | 2015 |
Prenatal valproic acid exposure disrupts tonotopic c-Fos expression in the rat brainstem.
Topics: Acoustic Stimulation; Animals; Auditory Perception; Autism Spectrum Disorder; Brain Stem; Disease Mo | 2015 |
The effect of ketogenic diet in an animal model of autism induced by prenatal exposure to valproic acid.
Topics: Animals; Anticonvulsants; Anxiety; Autism Spectrum Disorder; Behavior, Animal; Diet, Ketogenic; Dise | 2017 |
Overexpression of Homer1a in the basal and lateral amygdala impairs fear conditioning and induces an autism-like social impairment.
Topics: Acoustic Stimulation; Animals; Autism Spectrum Disorder; Basolateral Nuclear Complex; Carrier Protei | 2016 |
Alteration of spontaneous spectral powers and coherences of local field potential in prenatal valproic acid mouse model of autism.
Topics: Animals; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Disease Models, Animal; Expl | 2015 |
Prenatal valproic acid exposure disrupts tonotopic c-Fos expression in the rat brainstem.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Auditory Perception; Autism Spectrum Disorder; Brain | 2016 |
PI3K/AKT/mTOR-mediated autophagy in the development of autism spectrum disorder.
Topics: Age Factors; Animals; Animals, Newborn; Autism Spectrum Disorder; Autophagy; Cytokines; Disease Mode | 2016 |
Human Pluripotent Stem Cell-derived Cortical Neurons for High Throughput Medication Screening in Autism: A Proof of Concept Study in SHANK3 Haploinsufficiency Syndrome.
Topics: Autism Spectrum Disorder; Cell Differentiation; Cells, Cultured; Haploinsufficiency; Human Embryonic | 2016 |
Valproic acid exposure sequentially activates Wnt and mTOR pathways in rats.
Topics: Animals; Autism Spectrum Disorder; Autophagosomes; GABA Agents; Glycogen Synthase Kinase 3 beta; Mal | 2016 |
Increased anxiety-like behaviour and altered GABAergic system in the amygdala and cerebellum of VPA rats - An animal model of autism.
Topics: Amygdala; Animals; Anxiety; Autism Spectrum Disorder; Cerebellum; Disease Models, Animal; Female; GA | 2016 |
Prenatal valproate treatment produces autistic-like behavior and increases metabotropic glutamate receptor 1A-immunoreactivity in the hippocampus of juvenile rats.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Cognition; Disease Models, Animal; Female; GABA | 2016 |
A single low dose of valproic acid in late prenatal life alters postnatal behavior and glutamic acid decarboxylase levels in the mouse.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Disease Models, Animal; Female; Glutamate Decar | 2016 |
Developmental profiling of ASD-related shank3 transcripts and their differential regulation by valproic acid in zebrafish.
Topics: Animals; Autism Spectrum Disorder; Disease Models, Animal; Embryo, Nonmammalian; Gene Expression; Hu | 2016 |
Agmatine rescues autistic behaviors in the valproic acid-induced animal model of autism.
Topics: Agmatine; Animals; Autism Spectrum Disorder; Disease Models, Animal; Grooming; Hippocampus; Hyperkin | 2017 |
The transgenerational inheritance of autism-like phenotypes in mice exposed to valproic acid during pregnancy.
Topics: Animals; Autism Spectrum Disorder; Behavior, Animal; Female; Frontal Lobe; Male; Maternal Exposure; | 2016 |
Increased GABAA receptor binding in amygdala after prenatal administration of valproic acid to rats.
Topics: Amygdala; Animals; Autism Spectrum Disorder; Autoradiography; Azides; Benzodiazepines; Carbon Radioi | 2017 |
Abnormal Development of the Earliest Cortical Circuits in a Mouse Model of Autism Spectrum Disorder.
Topics: Animals; Auditory Cortex; Autism Spectrum Disorder; Disease Models, Animal; Female; Male; Mice; Neur | 2017 |