Page last updated: 2024-10-26

valproic acid and Aura

valproic acid has been researched along with Aura in 2662 studies

Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.

Research Excerpts

ExcerptRelevanceReference
"Participants with focal epilepsy were randomised to receive lamotrigine, levetiracetam or zonisamide."9.41Lamotrigine versus levetiracetam or zonisamide for focal epilepsy and valproate versus levetiracetam for generalised and unclassified epilepsy: two SANAD II non-inferiority RCTs. ( Appleton, R; Baker, G; Balabanova, S; Brown, R; Burnside, G; Hindley, D; Howell, S; Hughes, DA; Leach, JP; Maguire, M; Marson, AG; Mohanraj, R; Plumpton, CO; Sills, G; Smith, D; Smith, PE; Taylor, C; Tudur-Smith, C; Williamson, PR, 2021)
"Hyperammonemia can occur after acute overdose or chronic use of valproic acid (VPA)."9.41Risk factors of hyperammonemia in epilepsy patients with valproic acid therapy. ( Kim, DW; Kwack, DW, 2023)
"This trial evaluated the effect of cannabidiol on steady-state pharmacokinetics of stiripentol or valproate in patients with epilepsy, and the safety and tolerability of cannabidiol."9.34A Phase II Randomized Trial to Explore the Potential for Pharmacokinetic Drug-Drug Interactions with Stiripentol or Valproate when Combined with Cannabidiol in Patients with Epilepsy. ( Arenas Cabrera, CM; Ben-Menachem, E; Critchley, D; Crockett, J; Gunning, B; Morrison, G; Tayo, B; Toledo, M; VanLandingham, K; Wray, L, 2020)
"To estimate the safety and efficacy of sodium valproate combined with levetiracetam in paediatric patients with epilepsy based on randomized controlled trials (RCTs)."9.22Combined effects of levetiracetam and sodium valproate on paediatric patients with epilepsy: a systematic review and meta-analysis. ( Yang, J; Zhu, X; Zhu, Y, 2022)
"A literature search was performed in the PubMed, Embase, and OVID-Medline databases to identify articles related to epilepsy and lamotrigine that were published from the establishment of the database to April 2021."9.22The efficacy of lamotrigine after failure of the first administration of valproate in treating epilepsy: a systematic review and meta-analysis. ( He, J; Wu, X; Zhou, D, 2022)
"This post-hoc subgroup analysis of data from an unblinded, randomized, 52-week superiority study (KOMET) compared the effectiveness of levetiracetam (LEV) with extended-release sodium valproate (VPA-ER) and controlled-release carbamazepine (CBZ-CR) as monotherapy in patients aged ≥ 60 years with newly diagnosed epilepsy."9.22Comparative effectiveness of levetiracetam, valproate and carbamazepine among elderly patients with newly diagnosed epilepsy: subgroup analysis of the randomized, unblinded KOMET study. ( Marson, AG; Noack-Rink, M; Pohlmann-Eden, B; Ramirez, F; Tofighy, A; Trinka, E; Werhahn, KJ; Wild, I, 2016)
"This Phase I, open-label, dose-escalation study investigated the effects of steady-state brivaracetam on the pharmacokinetics of carbamazepine in patients with epilepsy, with and without valproate co-administration."9.22Pharmacokinetic interaction of brivaracetam on carbamazepine in adult patients with epilepsy, with and without valproate co-administration. ( Brodie, MJ; Sargentini-Maier, ML; Stockis, A, 2016)
"Eighty-one patients participated in the study: 51 patients with chronic epilepsy (G1) treated with carbamazepine (CBZ) or valproic acid (VPA), and 30 patients with newly diagnosed epilepsy (G2)."9.16The effect of vitamin B supplementation on homocysteine metabolism and clinical state of patients with chronic epilepsy treated with carbamazepine and valproic acid. ( Bochyńska, A; Graban, A; Gugała-Iwaniuk, M; Lechowicz, W; Lipczyńska-Łojkowska, W; Lipska, B; Restel, M; Ryglewicz, D, 2012)
"This study aimed to evaluate the effects of monotherapy with valproate or oxcarbazepine on the linear growth of children with idiopathic epilepsy."9.16The effects of oxcarbazepine and valproate therapies on growth in children with epilepsy. ( Bideci, A; Camurdan, O; Cansu, A; Cinaz, P; Hirfanoglu, TL; Karaoglu, A; Serdaroglu, A; Yesilkaya, E, 2012)
"Two broad spectrum AEDs, the traditional drug of sustained-release formulation of valproate (SRVPA) and the new-generation drug of topiramate, were compared in patients with epilepsy as monotherapy in this multi-centre, observational cohort study from 2000 to 2011."9.16Outcomes of sustained-release formulation of valproate and topiramate monotherapy in patients with epilepsy: a multi-centre, cohort study. ( Cao, Q; Chen, G; Ding, M; Hu, X; Hu, Y; Huang, X; Li, H; Liu, J; Lu, Y; Peng, B; Shen, D; Sun, H; Wang, X; Wu, M; Xi, Z; Zeng, K; Zhang, Y; Zhou, Y, 2012)
"To investigate the effect of topiramate on bone mass and metabolism in premenopausal women with epilepsy."9.15The effect of topiramate monotherapy on bone mineral density and markers of bone and mineral metabolism in premenopausal women with epilepsy. ( Heo, K; Kim, WJ; Lee, BI; Lee, HW; Lee, SA; Rhee, Y; Shin, DJ; Song, HK; Song, K, 2011)
"This open label study suggests that the combination of valproate, lamotrigine, and a benzodiazepine can markedly reduce the frequency of epileptic drop attacks in patients with generalized or multifocal epilepsies."9.15Long-term control of epileptic drop attacks with the combination of valproate, lamotrigine, and a benzodiazepine: a 'proof of concept,' open label study. ( Bastos, FA; Machado, VH; Palmini, A; Rotert, R, 2011)
"To explore efficacy and tolerability outcomes of topiramate (TPM) in patients with epilepsy transitioning from valproic acid (VPA) because of insufficient efficacy and/or tolerability onto TPM."9.14Conversion from valproic acid onto topiramate in adolescents and adults with epilepsy. ( Bogdanow, M; Lüer, W; Ossig, W; Schauble, B; Schreiner, A; Stollhoff, K; Unkelbach, S, 2009)
" We evaluated the reproductive endocrine and insulin-related metabolic parameters in men and women with untreated epilepsy randomized to valproate (n=44) or lamotrigine (n=37) monotherapy for 12 months."9.14Effects of valproate or lamotrigine monotherapy on the reproductive endocrine and insulin-related metabolic profile in Chinese adults with epilepsy: a prospective randomized study. ( Chan, IH; Chan, MH; Hui, AC; Hui, KF; Kwan, P; Lam, CW; Leung, H; Ng, PW; Yip, FP, 2009)
"Valproate (VPA) administration may be associated with adverse metabolic effects, among is hyperammonemia, which could suggest metabolic abnormalities as carnitine deficiency."9.14The risk of asymptomatic hyperammonemia in children with idiopathic epilepsy treated with valproate: relationship to blood carnitine status. ( Abdella, MM; Hamed, SA, 2009)
"For a retrospective observational investigation based on real clinical practice of relative efficacy of valpoic acid (VPA), carbamazepine (CBZ) and topiramate (TPM) we have selected 106 patients with age of seizure onset before 17 years with a undoubted diagnosis of symptomatic or cryptogenic occipital lobe epilepsy (OLE), who had received treatment according to ILAE recommendations, and observation time since the last treatment change was from 2 to 10 years."9.14[Comparative efficacy of carbamazepine, valproic acid and topiramate in symptomatic and cryptogenic occipital lobe epilepsy in children]. ( , 2010)
"To evaluate development of components of polycystic ovary syndrome (PCOS) and PCOS in women with epilepsy initiating valproate or lamotrigine therapy."9.13Hyperandrogenism, ovulatory dysfunction, and polycystic ovary syndrome with valproate versus lamotrigine. ( Adams, JM; Bhatt, M; Hayes, FJ; Isojärvi, J; Morrell, MJ; Ozkara, C; Sluss, PM; Warnock, CR, 2008)
"To evaluate the efficacy and tolerability of the treatment with valproic acid (VPA) in patients with status epilepticus (SE) or acute repetitive seizures (ARS) comparing it with phenytoin (PHT) treatment."9.13Treatment of status epilepticus and acute repetitive seizures with i.v. valproic acid vs phenytoin. ( Dabby, R; Gilad, R; Izkovitz, N; Lampl, Y; Rapoport, A; Sadeh, M; Weller, B, 2008)
"The present study was designed to reveal changes of cognitive processes in epilepsy (EP) patients with Topiramate (TPM) or Valproate (VPA) treatment using Wechsler Adult Intelligence Scale (WAIS-CR) and event-related potential (ERP)."9.13Attention changes in epilepsy patients following 3-month topiramate or valproate treatment revealed by event-related potential. ( Sun, W; Wang, W; Wang, Y; Wu, X, 2008)
" This paper aims to undertake a comprehensive review regarding the possible risks of four classical (phenytoin, carbamazepine, phenobarbital, and valproate) and two newer (lamotrigine and levetiracetam) AEDs during pregnancy."9.12Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications. ( Demir, O; Kaplan, YC, 2021)
"This study was performed to evaluate carnitine deficiency in a large series of epilepsy children and adolescents treated with old and new antiepileptic drugs with or without ketogenic diet."9.12Plasma free carnitine in epilepsy children, adolescents and young adults treated with old and new antiepileptic drugs with or without ketogenic diet. ( Auricchio, G; Coppola, G; Epifanio, G; Federico, RR; Pascotto, A; Resicato, G, 2006)
"In eight women treated with lamotrigine monotherapy, the lamotrigine dose/plasma concentration (D/C) ratio increased by 295% from baseline outside pregnancy to midgestation, whereas in six women treated with lamotrigine in combination with valproate, the increase was only 60%."9.12Valproate effects on kinetics of lamotrigine in pregnancy and treatment with oral contraceptives. ( Luef, G; Ohman, I; Pittschieler, S; Sabers, A; Tomson, T, 2006)
"We have performed a randomised, prospective study to compare the efficacy and tolerability of sodium valproate (VPA) and lamotrigine (LTG) monotherapy, and their effects on circulating androgenic hormones, in newly diagnosed epilepsy."9.12Sodium valproate versus lamotrigine: a randomised comparison of efficacy, tolerability and effects on circulating androgenic hormones in newly diagnosed epilepsy. ( Brodie, MJ; Butler, E; Hitiris, N; Leach, JP; Leach, VM; Parker, P; Sills, GJ; Stephen, LJ; Wilson, EA, 2007)
"To determine whether levetiracetam (LEV) affects plasma concentrations of carbamazepine, valproic acid, topiramate, and lamotrigine in children with epilepsy."9.12Lack of pharmacokinetic interaction of levetiracetam on carbamazepine, valproic acid, topiramate, and lamotrigine in children with epilepsy. ( De Smedt, H; Otoul, C; Stockis, A, 2007)
" The aim of this study was to evaluate thyroid function in 78 girls taking carbamazepine (CBZ), oxcarbazepine (OXC), or valproate (VPA) monotherapy for epilepsy and after withdrawal of the treatment."9.11Thyroid function in girls with epilepsy with carbamazepine, oxcarbazepine, or valproate monotherapy and after withdrawal of medication. ( Isojärvi, JI; Knip, M; Mikkonen, K; Myllylä, VV; Pakarinen, AJ; Rättyä, J; Vainionpää, LK, 2004)
"In a novel double-blind trial, topiramate was compared with the investigator's choice of carbamazepine or valproate as first-line therapy in patients as young as 6 years of age with newly diagnosed epilepsy."9.11Topiramate, carbamazepine, and valproate monotherapy: double-blind comparison in children with newly diagnosed epilepsy. ( Neto, W; Wang, S; Wheless, JW, 2004)
"This randomized, open-label study was designed to compare the efficacy and tolerability of lamotrigine monotherapy with those of valproate and carbamazepine monotherapy in patients with epilepsy whose seizures were uncontrolled on their prestudy antiepileptic drug monotherapy."9.11Efficacy and tolerability of conversion to monotherapy with lamotrigine compared with valproate and carbamazepine in patients with epilepsy. ( Fakhoury, TA; Hammer, AE; Messenheimer, JA; Vuong, A, 2004)
"A dosing algorithm was used to guide the conversion of 77 patients with epilepsy (16 years of age) from valproate monotherapy through lamotrigine adjunctive therapy at 200mg daily to lamotrigine monotherapy at 500 mg daily in an open-label study comprising a lamotrigine escalation phase (8 weeks), a valproate withdrawal phase (6 weeks), and a lamotrigine monotherapy phase (4 weeks)."9.11A dosing algorithm for converting from valproate monotherapy to lamotrigine monotherapy in patients with epilepsy. ( Biton, V; Blum, D; Hammer, AE; Messenheimer, JA; Natarajan, S; Sale, ME; Vuong, A, 2005)
"To compare topiramate (TPM) with investigator's choice of carbamazepine (CBZ) or valproate (VPA) for initial treatment in patients with newly diagnosed epilepsy."9.10Topiramate, carbamazepine and valproate monotherapy: double-blind comparison in newly diagnosed epilepsy. ( Brodie, MJ; Chadwick, DW; Mattson, RH; Neto, W; Privitera, MD; Wang, S, 2003)
"The authors assessed the effect of concomitant antiepileptic therapy on steady-state plasma concentrations of the new antiepileptic drug (AED) topiramate and the potential relation between topiramate plasma levels and side effects in a cohort of 116 patients with epilepsy."9.10Topiramate therapeutic monitoring in patients with epilepsy: effect of concomitant antiepileptic drugs. ( Albani, F; Avoni, P; Baruzzi, A; Contin, M; Riva, R, 2002)
"We studied the efficacy of felbamate (FBM) in combination with valproic acid (VPA) in 13 patients with the Lennox-Gastaut syndrome and evaluated the contribution of each drug."9.09The efficacy of felbamate as add-on therapy to valproic acid in the Lennox-Gastaut syndrome. ( Flamini, R; Gaillard, WD; Kelley, K; Ko, D; Malow, B; Reeves-Tyer, P; Siegel, H; Stertz, B; Theodore, WH, 1999)
"5-18 yrs with intractable epilepsy and comedicated with carbamazepine or valproate."9.09Plasma and urinary serotonin and 5-HIAA in children treated with lamotrigine for intractable epilepsy. ( Jović, NJ; Majkić-Singh, N; Milovanović, DD; Mirković, D, 1999)
"to describe the population pharmacokinetics of lamotrigine (LTG) in developmentally disabled (DD) patients with epilepsy and (2) to determine if there is an effect of valproate (VPA) concentration on the extent of the pharmacokinetic interaction between VPA and LTG."9.09Lack of an effect of valproate concentration on lamotrigine pharmacokinetics in developmentally disabled patients with epilepsy. ( Anderson, GD; Gidal, BE; Lanning, A; Rutecki, PR; Shaw, R, 2000)
" The primary aim of the study was to evaluate lamotrigine add-on therapy and consecutive monotherapy in patients with epilepsy whose seizures were not controlled by carbamazepine or valproate."9.09Open study evaluating lamotrigine efficacy and safety in add-on treatment and consecutive monotherapy in patients with carbamazepine- or valproate-resistant epilepsy. ( Jozwiak, S; Terczynski, A, 2000)
"Lamotrigine (LTG) is one of the newer antiepileptic drugs which has been shown to have a spectrum of drug interactions (including with other epilepsy drugs) that can have a pronounced effect on LTG kinetics."9.09Clinical study of lamotrigine and valproic acid in patients with epilepsy: using a drug interaction to advantage? ( Black, AB; Lam, E; Morris, RG; Westley, IS, 2000)
"To compare the incidence and magnitude of change in body weight associated with lamotrigine or divalproex sodium monotherapy in patients with epilepsy."9.09Weight change associated with valproate and lamotrigine monotherapy in patients with epilepsy. ( Barrett, PS; Biton, V; Hammer, AE; Mirza, W; Montouris, G; Vuong, A, 2001)
"We retrospectively evaluated the ability of Scatchard binding equation method to predict the unbound serum valproic acid (VPA) concentration in 37 pediatric patients with epilepsy receiving VPA monotherapy."9.08Evaluation of binding equation method for prediction of unbound serum valproic acid concentration in pediatric patients with epilepsy. ( Fujii, I; Kodama, H; Kodama, Y; Koike, Y; Kuranari, M; Takeyama, M; Yasunaga, F, 1995)
"To assess the effects of carbamazepine vs valproate sodium on cognitive functioning in patients with epilepsy compared with normal control subjects."9.08Effect of valproate on cognitive functioning. Comparison with carbamazepine. The Department of Veterans Affairs Epilepsy Cooperative Study 264 Group. ( Cattanach, L; Collins, JF; Cramer, JA; Delaney, RC; Mattson, RH; Prevey, ML, 1996)
" This paper presents an analysis of body weight data gathered during a randomized trial comparing valproate with carbamazepine in 260 children aged 4-15 years with newly-diagnosed epilepsy."9.08Weight gain with valproate or carbamazepine--a reappraisal. ( Easter, D; O'Bryan-Tear, CG; Verity, C, 1997)
"We have analyzed the records retrospectively and interviewed 70 adult patients attending an epilepsy clinic on VPA mono- or polytherapy followed over a median of 27 months (range 3-189), as well as 20 patients on carbamazepine (CBZ) monotherapy."9.08Weight gain in epileptic patients during treatment with valproic acid: a retrospective study. ( Corman, CL; Guberman, AH; Leung, NM, 1997)
"We report the results of an open trial with lamotrigine (LTG) as add-on drug in children and adolescents with refractory epilepsy and mental delay."9.08Lamotrigine as add-on drug in children and adolescents with refractory epilepsy and mental delay: an open trial. ( Coppola, G; Pascotto, A, 1997)
"To evaluate population pharmacokinetics and the relationship between plasma concentration and daily dose of valproic acid (VPA) in a homogeneous group of children with epilepsy."9.08Valproic acid clearance in children with epilepsy. ( López, E; Quintana, MB; Rodríguez, I; Sánchez-Alcaraz, A, 1998)
"Sixty-four new cases of childhood epilepsy were randomly assigned to either carbamazepine, phenytoin or sodium valproate, and were assessed with behavioural measures before medication and after one and six months of treatment."9.07Psychiatric aspects of epilepsy in childhood treated with carbamazepine, phenytoin or sodium valproate: a random trial. ( Berg, I; Butler, A; Ellis, M; Foster, J, 1993)
"Thirteen children with intractable epilepsy were treated by means of three-times-daily administration of a conventional preparation of valproic acid (C-VPA) and twice-daily administration of a new slow-release preparation of VPA (SR-VPA) with the cross-over technique."9.07A comparative clinical and pharmacokinetic study of a new slow-release versus conventional preparations of valproic acid in children with intractable epilepsy. ( Fukuyama, Y; Imaizumi, T; Izumi, T, 1992)
"The effects of adding vigabatrin (GVG) to the antiepileptic regimens of 16 children with refractory epilepsy have been studied."9.07Coadministration of vigabatrin and valproate in children with refractory epilepsy. ( Armijo, JA; Arteaga, R; Herranz, JL; Valdizán, EM, 1992)
"Sixty-four new cases of childhood epilepsy were randomly assigned to either carbamazepine, phenytoin or sodium valproate, and were assessed with cognitive tests before medication and three subsequent times over a year."9.07Cognitive impairment in new cases of epilepsy randomly assigned to carbamazepine, phenytoin and sodium valproate. ( Berg, I; Butler, R; Forsythe, I; McGuire, R, 1991)
"Taltrimide was compared with valproate and placebo in 17 patients with intractable epilepsy being on carbamazepine monotherapy."9.06A controlled study with taltrimide and sodium valproate: valproate effective in partial epilepsy. ( Allonen, H; Iivanainen, M; Neuvonen, PJ; Parantainen, J; Tamminen, M; Tokola, O; Waltimo, O, 1990)
"Long-term use of valproic acid in treating children with epilepsy can lead to a reduction in 25-OH-VitD and BMD."9.05Effects of valproic acid on skeletal metabolism in children with epilepsy: a systematic evaluation and meta-analysis based on 14 studies. ( Biaoxue, R; Chunyan, W; Min, L, 2020)
"We evaluated valproic acid (VPA) for 6 months as therapy for uncontrolled seizures in 100 children, 38 with partial and 62 with generalized epilepsy."9.05Treatment of childhood epilepsy with valproic acid: results of the first 100 patients in a 6-month trial. ( Couri, D; Sherard, ES; Steiman, GS, 1980)
"Valproic acid (VPA) as a widely used primary medication in the treatment of epilepsy is associated with reversible or irreversible hepatotoxicity."9.01Valproic Acid and the Liver Injury in Patients with Epilepsy: An Update. ( Chen, F; Guo, HL; Hu, YH; Jing, X; Lu, XP; Ni, MM; Qiu, JC; Sun, JY; Wang, T; Xu, ZJ, 2019)
"We systematically reviewed studies to provide current evidence about the incidence and risk of alopecia in patients undergoing valproic acid (VPA) therapy."9.01Risk of valproic acid-related alopecia: A systematic review and meta-analysis. ( Liu, L; Wang, H; Wang, X; Xu, D; Zhu, L, 2019)
"Valproic acid (VPA) is frequently used in the treatment of epilepsy."9.01CPS1 T1405N polymorphism, HDL cholesterol, homocysteine and renal function are risk factors of VPA induced hyperammonemia among epilepsy patients. ( Chen, D; Chen, L; Chen, P; Gao, X; Li, C; Li, H; Li, Y; Tian, Q; Tian, X; Wen, J; Yang, H; Zhang, M, 2019)
"Lamotrigine is used in pregnancy to control epilepsy and mood disorders."8.95Pregnancy Outcomes Following In Utero Exposure to Lamotrigine: A Systematic Review and Meta-Analysis. ( Adams-Webber, T; Barzilay, E; Leibson, T; Nulman, I; Pariente, G; Shulman, T, 2017)
"To determine whether valproate (VPA) monotherapy influences homocysteine metabolism in patients with epilepsy."8.90Increased homocysteine levels in valproate-treated patients with epilepsy: a meta-analysis. ( Chen, Y; Chen, Z; Fang, Z; Ni, G; Qin, J; Zhou, J; Zhou, L, 2014)
"In the last years, a growing body of literature indicates an association between valproic acid therapy and weight gain."8.87Weight gain following treatment with valproic acid: pathogenetic mechanisms and clinical implications. ( Chiarelli, F; Coppola, G; D'Egidio, C; Mohn, A; Verrotti, A, 2011)
" The present study aims to determine the distribution pattern of UGT1A6 and UGT2B7 gene polymorphism and its possible impact on the metabolism of valproic acid (VPA) and carbamazepine (CBZ) in patients with epilepsy from Khyber Pakhtunkhwa region of Pakistan."8.84Distribution pattern of UGT1A6 and UGT2B7 gene polymorphism and its impact on the pharmacokinetics of valproic acid and carbamazepine: Prospective genetic association study conducted in Pakistani patients with epilepsy. ( Ali, N; Almarshad, F; Alshahrani, AM; Jamil, A; Saleh Faisal, M, 2024)
"The author reports one case of pseudocyst of the pancreas, an uncommon disorder in children, secondary to pancreatitis in a 9-year-old girl treated with valproic acid for epilepsy."8.82Pancreatic pseudocyst caused by valproic acid: case report and review of the literature. ( Hernández, F; Queizán, A; Rivas, S, 2003)
"Valproic acid (VPA) is a commonly prescribed medication approved for use in the United States for epilepsy, migraine, and bipolar disorder."8.82Acute pancreatitis in children from Valproic acid: case series and review. ( Feldman-Winter, LB; Goldfarb, O; Grauso-Eby, NL; McAbee, GN, 2003)
" However, a particular association of valproate and carbamazepine with neural tube defects (NTDs)--specifically, with spina bifida aperta (SB)--has been identified."8.82Management issues for women with epilepsy: neural tube defects and folic acid supplementation. ( Yerby, MS, 2003)
"To correlate lamotrigine (LTG) serum concentrations (levels) with tolerability in patients with epilepsy."8.82Correlating lamotrigine serum concentrations with tolerability in patients with epilepsy. ( Adams, DJ; Bazil, CW; Buchsbaum, R; Du, Y; Hager, M; Hirsch, LJ; Morrell, MJ; Resor, SR; Spencer, HT; Straka, T; Weintraub, D, 2004)
"A 12-year-old boy developed pancreatitis, complicated by a pancreatic pseudocyst, as an adverse reaction to valproic acid (VPA) treatment for epilepsy."8.82Pancreatitis, complicated by a pancreatic pseudocyst associated with the use of valproic acid. ( Houben, ML; Stroink, H; van Dijken, PJ; Wilting, I, 2005)
"To provide an overview of the evidence comparing carbamazepine (CBZ) and valproate (VPA) monotherapy for epilepsy, investigating whether existing data support the current practice of preferring CBZ for partial-onset and VPA for generalized-onset seizures."8.81Carbamazepine versus valproate monotherapy for epilepsy: a meta-analysis. ( Chadwick, DW; Clough, H; Hutton, JL; Marson, AG; Williamson, PR, 2002)
"Carbamazepine and valproate are drugs of first choice for epilepsy."8.80Carbamazepine versus valproate monotherapy for epilepsy. ( Chadwick, DW; Clough, HE; Hutton, JL; Marson, AG; Williamson, PR, 2000)
"We reported a case of acute pancreatitis occurring during administration of valproic acid for epilepsy."8.78[A case of acute pancreatitis during administration of valproic acid]. ( Ito, S; Kobayashi, K; Kuniya, T; Mimasu, S; Momota, T, 1993)
"An 11 year-old epileptic boy, treated with valproic acid developed after 11 months on therapy a severe acute pancreatitis."8.78[Acute pancreatitis and valproic acid]. ( Bovier Lapierre, M; Jalaguier, E; Kayemba Kay's Kabangu, S, 1991)
"Resistance to valproic acid (VPA) is a major challenge for epilepsy treatment."8.31Overexpression of Homer1b/c induces valproic acid resistance in epilepsy. ( Li, Y; Li, Z; Lu, J; Wang, G; Wang, Y, 2023)
"Valproic acid (VPA)-induced hyperammonemia (HA) is a rare adverse effect reported even at therapeutic VPA levels."8.31Valproic acid-induced hyperammonemia in neuropsychiatric disorders: a 2-year clinical survey. ( Aghamollaii, V; Ghayyem, H; Hassani, M; Hosseini, H; Mayeli, M; Shafie, M; Shakiba, A, 2023)
"To investigate the efficacy and mechanisms of Dingxian pill combined with valproic acid (VPA) on pentylenetetrazol-induced chronical epilepsy in rats."8.31Efficacy and mechanisms of Dingxian pill combined with valproic acid on pentylenetetrazol-induced chronic epilepsy in rats. ( Dongxiao, QU; Guoyi, LI; Jie, T; Jiwei, C; Liji, C; Limin, Z; Qian, X; Yiqin, GE; Yonghua, X; Yudan, Z, 2023)
"To investigate the antiseizure medication (ASM) doses required to achieve seizure freedom and their correlation with the World Health Organization's defined daily doses (DDDs) in patients aged 16 years or older with newly diagnosed epilepsy."8.31Prescribed antiseizure medication doses and their relation to defined daily doses for achieving seizure freedom in newly diagnosed patients with epilepsy. ( Hersi, H; Peltola, J; Raitanen, J; Saarinen, JT, 2023)
"Valproic acid (VPA) is a relatively safe drug widely used for the treatment of epileptic seizures and mania in bipolar disorder, as well as the prevention of migraine headaches."8.31Acute pancreatitis during valproic acid administration in a patient with vascular dementia, epileptic seizures, and psychiatric symptoms: a case report. ( Harada, M; Hashimoto, R; Igata, R; Ikenouchi, A; Isomoto, N; Konishi, Y; Okamoto, N; Shinkai, T; Yanaga, M; Yoshimura, R, 2023)
"A prospective longitudinal study was conducted to assess the Apo B100/A1 ratio as a marker of cardiovascular risk in children with epilepsy aged 5-14 years on long-term anti-seizure medication monotherapy with either sodium valproate, oxcarbazepine, or levetiracetam."8.31Change in Apo B100/A1 Ratio in Children With Epilepsy on Monotherapy With Sodium Valproate, Oxcarbazepine or Levetiracetam. ( Dhama, A; Kaushik, JS; Lekhwani, S, 2023)
"Dose-adjusted lamotrigine troughs in epilepsy patients with variant UGT2B7 -161C > T or UGT1A4*3 c."8.31Bearing variant alleles at uridine glucuronosyltransferase polymorphisms UGT2B7 -161C > T (rs7668258) or UGT1A4*3 c.142 T > G (rs2011425) has no relevant consequences for lamotrigine troughs in adults with epilepsy. ( Božina, N; Domjanović, IK; Gadže, ŽP; Ganoci, L; Lovrić, M; Romić, ZČ; Šimičević, L; Sporiš, IŠ; Trkulja, V, 2023)
" The aim of this study was to explore the association of SCN1A polymorphisms with efficacy and adverse drug reactions (ADRs) related to valproic acid (VPA) among Chinese children with epilepsy."8.31SCN1A Polymorphisms and Haplotypes Are Associated With Valproic Acid Treatment Outcomes in Chinese Children With Epilepsy. ( Fan, X; Guo, H; He, Y; Li, W; Lu, J; Shen, X; Xia, H; Zhang, J; Zhu, J, 2023)
"Valproic acid (VPA) and levetiracetam (LEV) are used in epilepsy treatment."8.12Successful Treatment of Symptomatic Epilepsy with Oral Valproic Acid and Levetiracetam in a Patient with Short-bowel Syndrome. ( Hayashi, M; Iijima, A; Isozaki, R; Kurishima, A; Shimozato, R; Shioda, T, 2022)
"Valproic acid (VPA) is used for the treatment of epilepsy and bipolar disorder (BD)."8.12Long-term use of valproic acid reduced mortality in bipolar disorder patients in a Taiwanese population: An association analysis using the national health insurance research database (NHIRD). ( Hsieh, TC; Lin, CC; Wu, LS, 2022)
"In a nation-wide population-based longitudinal register linkage study for the first time 1) to investigate long-term response to lithium in patients with bipolar disorder with and without comorbid epilepsy, and 2) within patients with bipolar disorder and comorbid epilepsy to compare differences in responses between lithium, valproate and lamotrigine."8.12Response to lithium and anticonvulsants among patients with bipolar disorder with and without comorbid epilepsy - A nation-wide population-based longitudinal study. ( Budtz-Jørgensen, E; Gerds, T; Kessing, LV; Ziersen, SC, 2022)
" Here we examine the effects of valproic acid (VA) plus 4-phenylbutyric acid (4-PBA) on abnormal electrical brain activity, ER stress and apoptosis in acute seizures induced by pentylenetetrazole (PTZ)."8.124-Phenylbutyric Acid Plus Valproic Acid Exhibits the Therapeutic and Neuroprotective Effects in Acute Seizures Induced by Pentylenetetrazole. ( Amanvermez, R; Arslan, G; Gün, S; Rzayev, E; Tiryaki, ES, 2022)
"AbstractThe aim of this study was to explore the effect of lamotrigine (LTG) on blood ammonia level in patients with epilepsy and identify risk factors affecting blood ammonia level."8.12Risk factors of elevated blood ammonia level in epilepsy patients treated with lamotrigine. ( Chen, J; Chen, X; Chen, Y; Miao, J; Wang, R; Zeng, J; Zhuang, X, 2022)
" Consecutive adolescent patients with epilepsy aged 11-17 years with partial or generalized seizures, treated with either levetiracetam or valproic acid for at least 6 months, and healthy controls were recruited."8.12Irritability and its relationship with psychosocial symptoms and quality of life in adolescents with epilepsy receiving levetiracetam therapy: A case-control study. ( Tekin, E; Tekin, U; Uçar, HN, 2022)
"To compare the hazard for all-cause mortality and mortality due to heart failure (HF) between valproate (VPA) and levetiracetam (LEV)/lamotrigine (LTG) users in patients aged ≥ 65 with comorbidities of epilepsy and HF."8.12The Relationship Between Valproate and Lamotrigine/Levetiracetam Use and Prognosis in Patients With Epilepsy and Heart Failure: A Danish Register-Based Study. ( Gardella, E; Kragholm, K; Liang, D; Polcwiartek, C; Sessa, M, 2022)
"To study the association between CYP2C19*2 (681 G > A) and UGT1A6*2 (552A > C) polymorphisms on Valproic acid (VPA)-induced weight gain in People with epilepsy (PWE)."8.02CYP2C19 & UGT1A6 genetic polymorphisms and the impact on Valproic acid-induced weight gain in people with epilepsy: Prospective genetic association study. ( Kamalanathan, S; Kesavan, R; Mani, B; Nair, PP; Narayan, SK; Sekhar, A, 2021)
"A retrospective chart review conducted at King Abdulaziz University Hospital, Jeddah, Kingdome of Saudi Arabia, for children below 2 years of age diagnosed with epilepsy and treated with valproic acid from January 2016 to January 2020."8.02Valproic acid for children below 2 years of age with epilepsy. ( Alfawaz, NS; Almahmudi, SM; Alrabghi, MO; Bin Mahfouz, MM; Muthaffar, OY, 2021)
"Children aged 1 to 12 years, diagnosed with epilepsy (generalized or focal seizures), treated with valproate (n = 40) and valproate with add-on levetiracetam (n = 40) were included."8.02Effect of valproate and add-on levetiracetam on inflammatory biomarkers in children with epilepsy. ( Gupta, R; Halder, S; Kar, R; Labh, R; Narang, M, 2021)
"The purpose of this study was to establish a protein binding model of unbound valproic acid (VPA) based on Chinese pediatric patients with epilepsy and provide a reference for clinical medication."8.02Population pharmacokinetics of unbound valproic acid in pediatric epilepsy patients in China: a protein binding model. ( Gu, X; Hu, Y; Jiao, Z; Li, Z; Ma, M; Peng, Q; Sheng, C; Yu, S; Zhou, B; Zhu, M, 2021)
" In the pharmacodynamic interaction study, seizures were induced using pentylenetetrazole (PTZ) (60 mg/kg, i."8.02Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats. ( Agarwal, A; Arora, R; Ganeshan N, S; Gupta, YK; Kaleekal, T; Kumar, R; Sarangi, SC, 2021)
"We measured carnitine levels before and after pivalate-conjugated antibiotic (PCA) use in six patients with epilepsy who were prescribed valproate (VPA)."8.02Carnitine supplementation prevents carnitine deficiency caused by pivalate-conjugated antibiotics in patients with epilepsy prescribed valproate. ( Azuma, Y; Iwayama, H; Kurahashi, H; Numoto, S; Okumura, A, 2021)
"Overall, serum free carnitine levels showed significant negative correlations with epilepsy duration, VPA treatment duration, daily VPA dose, and blood VPA concentration."8.02Factors associated with blood carnitine levels in adult epilepsy patients with chronic valproic acid therapy. ( Miyaoka, H; Saito, M; Takizawa, T, 2021)
"Although several studies have indicated that valproate (VPA) and oxcarbazepine (OXC) cause reproductive endocrine disorders and sexual dysfunction, there remains some controversy regarding these issues in males with epilepsy."8.02A Comparative Study of the Effects of Valproate and Oxcarbazepine on Sexual Function, Sperm Quality, and Sex Hormones in Males with Epilepsy. ( Chen, L; Guo, Y; Sun, H; Wu, D; Yu, L; Zhu, Q, 2021)
"We measured the serum-free carnitine (FC), VPA, aspartate aminotransferase, alanine aminotransferase, amylase, and ammonia levels, and the platelet count, in 69 patients with childhood-onset epilepsy treated with VPA."8.02Effects of l-carnitine supplementation in patients with childhood-onset epilepsy prescribed valproate. ( Azuma, Y; Iwayama, H; Kurahashi, H; Numoto, S; Okumura, A; Takagi, M, 2021)
"The aim of the study was to investigate the risk of subclinical atherosclerosis independent from obesity and high blood lipid levels in pediatric patients with idiopathic epilepsy receiving valproic acid or levetiracetam monotherapy by evaluating carotid intima-media thickness (CIMT) and Epicardial adipose tissue thickness (EATT)."7.96Effects of valproic acid and levetiracetam monotherapy on carotid intima-media and epicardial adipose tissue thickness in non-obese children with epilepsy. ( Karatoprak, E; Tosun, O, 2020)
"We sought to explore the effects of sodium valproate combined with lamotrigine on quality of life and serum inflammatory factors in patients with poststroke secondary epilepsy."7.96Effects of Sodium Valproate Combined with Lamotrigine on Quality of Life and Serum Inflammatory Factors in Patients with Poststroke Secondary Epilepsy. ( Guo, D; Hao, F; Li, X; Liu, X; Sun, J; Tang, W; Tao, S, 2020)
"The aim of the study was to investigate how age and genetic polymorphisms of UGT1A6 and UGT2B7 contribute to the concentrations of valproic acid (VPA) and its hepatotoxic metabolites in Chinese pediatric patients with epilepsy."7.96Impact of Age and Genotype on Serum Concentrations of Valproic Acid and Its Hepatotoxic Metabolites in Chinese Pediatric Patients With Epilepsy. ( Chen, Y; Li, G; Wang, M; Zhao, L; Zhao, M, 2020)
"Here, we present a multicenter series of patients with developmental and epileptic encephalopathies (DEE) and related electroclinical patterns (REP) other than Lennox-Gastaut syndrome (LGS) who were treated with rufinamide as add-on therapy."7.96Rufinamide as add-on therapy in children with epileptic encephalopathies other than Lennox-Gastaut syndrome: A study of 34 patients. ( Caraballo, RH; Espeche, A; Fasulo, L; Galichio, S; Pociecha, J; Reyes, G; Semprino, M, 2020)
"These findings suggest that carnitine deficiency is associated with the VPA dose and the serum VPA level in patients with bipolar disorder."7.96Association Between the Serum Carnitine Level and Ammonia and Valproic Acid Levels in Patients with Bipolar Disorder. ( Ishioka, M; Kubo, K; Miyazaki, K; Nakagami, T; Shimoda, K; Sugawara, N; Tarakita, N; Yasui-Furukori, N; Yokoyama, S, 2020)
"Dose individualization is essential in epilepsy treatment, especially in antiepileptic drugs that present high interindividual variability such as lamotrigine."7.96Dosing Recommendations Based on Population Pharmacokinetics of Lamotrigine in Mexican Adult Patients With Epilepsy. ( Chávez-Castillo, CE; Medellín-Garibay, SE; Milán-Segovia, RDC; Rodríguez-Leyva, I; Romano-Moreno, S, 2020)
"In January 2019, a new plant-derived purified cannabidiol preparation, approved by the US Food and Drug Administration, became commercially available for patients ≥2 years old with Lennox-Gastaut syndrome or Dravet syndrome."7.96Thrombocytopenia in pediatric patients on concurrent cannabidiol and valproic acid. ( Carlson, M; Dang, LT; Fedak Romanowski, EM; Joshi, SM; Leber, SM; McNamara, NA; Robertson, P; Shellhaas, RA; Smith, GC; Sturza, J; Ziobro, JM, 2020)
"To evaluate the changes of epileptiform activity index (EAI) as a measure of the efficacy and tolerability of treatment with valproic acid (VA) in patients with newly-diagnosed generalized and focal epilepsy."7.96[Dynamics of epileptiform activity, efficacy and tolerability of valproic acid in adults and adolescents with newly-diagnosed epilepsy]. ( Karlov, VA; Kozhokaru, AB; Orlova, AS; Pushkar, TN; Vlasov, PN, 2020)
"Due to the narrow therapeutic window of valproic acid (VPA), grievous adverse reactions such as hepatotoxicity, nephrotoxicity may occur in patients with epilepsy for a long time."7.96Valproic acid concentration and biochemical indexes in epilepsy outpatients during monotherapy or combination therapy. ( Luo, J; Ma, H; Pan, J; Wang, C; Wang, P; Yang, X, 2020)
"The aim of this study was to evaluate the effects of valproate (VPA), lamotrigine (LTG), and levetiracetam (LEV) on bone turnover and bone mineral density (BMD) in newly diagnosed adult patients with epilepsy."7.96Effects of valproate, lamotrigine, and levetiracetam monotherapy on bone health in newly diagnosed adult patients with epilepsy. ( Guo, Y; Huang, Y; Lin, Z; Yu, L, 2020)
"Phenobarbital and sodium valproate are broad spectrum and inexpensive antiepileptic drugs that are used to treat convulsive epilepsy."7.91Efficacy of phenobarbital and sodium valproate in treating convulsive epilepsy in rural northeast China. ( Li, J; Li, N; Lin, W; Yang, D; Zhao, D, 2019)
" A 13-year-old girl with genetically confirmed Pitt-Hopkins syndrome with uncontrolled seizures, while on treatment with levetiracetam and valproic acid, was started on perampanel, reaching seizure control."7.91Perampanel-induced hair curling in a patient with epilepsy associated with Pitt Hopkins syndrome. ( Calle-Lopez, Y; Knight, EP; Kotagal, P, 2019)
"The objective of this study was to evaluate the long-term safety, tolerability, and efficacy of cannabidiol in children with epilepsy."7.91Long-Term Safety, Tolerability, and Efficacy of Cannabidiol in Children with Refractory Epilepsy: Results from an Expanded Access Program in the US. ( Caminha Nunes, E; Cilio, MR; Oldham, MS; Rahdari, S; Sands, TT; Tilton, N, 2019)
"The aims of this study were to identify the influencing factors such as gender, age, dose and combinations of other antiepileptic drugs (AEDs), especially in triple combinations on the pharmacokinetic of Lamotrigine (LTG) in epilepsy patients of Northwest Chinese Han population."7.91The influence of concomitant antiepileptic drugs on lamotrigine serum concentrations in Northwest Chinese Han population with epilepsy. ( Han, X; Huang, J; Lv, J; Ma, L; Nie, X; Peng, L; Wang, J; Xia, L; Zan, X, 2019)
"Irritability has been described as a frequent adverse event in patients affected by epilepsy and treated with perampanel (PER), levetiracetam (LEV), and less frequently with valproic acid (VPA)."7.91Preliminary evidence about irritability in patients with epilepsy treated by perampanel as first add-on therapy compared to levetiracetam and valproic acid. ( Assogna, M; Canevini, MP; Izzi, F; Liguori, C; Mercuri, NB; Placidi, F; Turner, K, 2019)
"There is a large inter-individual variation in the efficacy of valproic acid (VPA) against epilepsy."7.91SCN1A and SCN2A polymorphisms are associated with response to valproic acid in Chinese epilepsy patients. ( Chen, X; Li, H; Lin, C; Luo, J; Shi, L; Wen, Z; Zhang, Z; Zhu, M, 2019)
"This study measured the serum carnitine levels in patients with epilepsy and determined the factors contributing to low carnitine levels."7.91Serum carnitine levels of children with epilepsy: Related factors including valproate. ( Iwayama, H; Kurahashi, H; Numoto, S; Okumura, A, 2019)
"Valproic acid (VPA) is used as one of the first-line antiepileptic drugs to control seizure in epilepsy patients."7.91Correlation of MCT1 and ABCC2 gene polymorphisms with valproic acid resistance in patients with epilepsy on valproic acid monotherapy. ( Chen, J; Chen, Z; Huang, M; Li, H; Qin, J; Ruan, H; Su, Q; Wang, X; Zhou, L; Zhou, S; Zhou, Y, 2019)
"The aim of this study is to evaluate if valproate (VPA) and levetiracetam (LEV) as monotherapy are associated with vitamin D deficiency among children with epilepsy."7.88Vitamin D deficiency in children with epilepsy taking valproate and levetiracetam as monotherapy. ( Aguilera-Albesa, S; Durá-Travé, T; Gallinas-Victoriano, F; Malumbres-Chacón, M; Moreno-Gónzalez, P; Yoldi-Petri, ME, 2018)
"To assess the effect of monotherapy with Carbamazepine (CBZ) and Sodium valproate (VPA) on serum 25-OH Vitamin D levels in children with epilepsy compared to controls."7.88Vitamin D Deficiency in Ambulant Children on Carbamazepine or Sodium Valproate Monotherapy. ( Devadathan, K; Mohammed Kunju, PA; Muthubeevi, S; Pillai, JP; Sasidharan, B; Sreedharan, M; Vasumathy Amma, MA, 2018)
"To explore the incidence and independent risk-factors of secondary carnitine deficiency in Chinese children with epilepsy on valproate monotherapy."7.88Carnitine Deficiency in Chinese Children with Epilepsy on Valproate Monotherapy. ( Hong, J; Qiliang, L; Wenqi, S, 2018)
"In the study, the effect of valproic acid on serum free/acylcarnitine levels and left ventricular systolic function in pediatric patients with idiopathic epilepsy receiving valproic acid was investigated."7.88Evaluation ofserum free carnitine/acylcarnitine levels and left ventricular systolic functions in children with idiopathic epilepsy receiving valproic acid. ( Celik, H; Ince, H; Kulhas Celik, I; Sungur, M; Tasdemir, HA, 2018)
"Adults with epilepsy on lamotrigine monotherapy (n = 131) or lamotrigine + valproate treatment (n = 74) were genotyped and steady-state lamotrigine and valproate morning troughs were determined as a part of routine therapeutic drug monitoring."7.88Interaction between ABCG2 421C>A polymorphism and valproate in their effects on steady-state disposition of lamotrigine in adults with epilepsy. ( Božina, N; Čajić, I; Ganoci, L; Klarica Domjanović, I; Lovrić, M; Petelin-Gadže, Ž; Trkulja, V, 2018)
"This study was aimed at identifying genetic and non-genetic risk factors for valproic acid (VPA)-induced hyperammonaemia in Chinese paediatric patients with epilepsy."7.88Risk Factors for Valproic Acid-induced Hyperammonaemia in Chinese Paediatric Patients with Epilepsy. ( Li, X; Zhang, T; Zhao, L; Zhu, X, 2018)
"Evaluation of biochemical derangements related to metabolic syndrome in epileptic patients on treatment with Valproic acid."7.88Biochemical derangements related to metabolic syndrome in epileptic patients on treatment with valproic acid. ( Bobby, Z; Nisha, Y; Wadwekar, V, 2018)
"Valproic acid (VPA) provides a common treatment for both epilepsy and bipolar disorder; however, common cellular mechanisms relating to both disorders have yet to be proposed."7.88Diacylglycerol kinase (DGKA) regulates the effect of the epilepsy and bipolar disorder treatment valproic acid in ( Kelly, E; Sharma, D; Wilkinson, CJ; Williams, RSB, 2018)
"Because the pharmacokinetic evaluation of valproic acid (VPA) based on total drug concentration may be misleading in patients with hypoalbuminemia as a result of saturable protein binding and saturable metabolism, we sought to investigate the usefulness of therapeutic drug monitoring of unbound VPA concentration in a real-world clinical context, with a focus on clinically significant neurologic adverse outcomes."7.85Clinical Importance of Monitoring Unbound Valproic Acid Concentration in Patients with Hypoalbuminemia. ( Doré, M; Frenette, AJ; San Juan, AE; Williamson, D, 2017)
"The aim of the study is to evaluate the association between genetic polymorphisms and valproic acid (VPA) concentration to dose ratio in children with epilepsy on VPA monotherapy."7.85Genetic polymorphisms and valproic acid plasma concentration in children with epilepsy on valproic acid monotherapy. ( Fang, F; Feng, W; Gao, B; Mei, S; Wu, X; Yang, W; Yu, Y; Zhao, Z; Zhu, L, 2017)
"This retrospective longitudinal study included 85 VPA-treated and 93 carbamazepine (CBZ)-treated (as a reference) young patients with epilepsy."7.83Cytochrome P450 2C19 polymorphisms and valproic acid-induced weight gain. ( Ishitsu, T; Kajiwara, A; Nakagawa, K; Noai, M; Oniki, K; Saruwatari, J; Soraoka, H; Tanamachi, Y, 2016)
"Valproic acid (VPA) is widely used in the treatment of children with epilepsy."7.83Effects of UGT2B7 Genetic Polymorphisms on Serum Concentrations of Valproic Acid in Chinese Children With Epilepsy Comedicated With Lamotrigine. ( Dong, Y; Guo, Y; Liang, M; Meng, H; Qiu, F; Wang, Q; Yun, W; Zhao, L, 2016)
"To confirm the hypothesis suggested above, a combined analysis of survival association of antiepileptic drug use at the start of chemoradiotherapy with temozolomide was performed in the pooled patient cohort (n = 1,869) of four contemporary randomized clinical trials in newly diagnosed glioblastoma: AVAGlio (Avastin in Glioblastoma; NCT00943826), CENTRIC (Cilengitide, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma and Methylated Gene Promoter Status; NCT00689221), CORE (Cilengitide, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma and Unmethylated Gene Promoter Status; NCT00813943), and Radiation Therapy Oncology Group 0825 (NCT00884741)."7.83Does Valproic Acid or Levetiracetam Improve Survival in Glioblastoma? A Pooled Analysis of Prospective Clinical Trials in Newly Diagnosed Glioblastoma. ( Chinot, O; Cloughesy, T; Gilbert, MR; Gorlia, T; Happold, C; Hegi, M; Mehta, MP; Nabors, LB; Perry, JR; Pugh, SL; Reardon, DA; Roth, P; Stupp, R; Weller, M; Wick, W, 2016)
"To identify the factors influencing topiramate pharmacokinetics (PK) in a large population of adult patients with epilepsy using population PK analysis."7.83Factors influencing topiramate clearance in adult patients with epilepsy: A population pharmacokinetic analysis. ( Bae, EK; Jang, IJ; Kim, TJ; Lee, J; Lee, KJ; Lee, SK; Moon, J; Shin, D; Shin, JW; Shin, YW, 2016)
"Studies of the effect of oxcarbazepine (OXC) on body growth of children with epilepsy are rare and their results are controversial."7.83Weight gain in children on oxcarbazepine monotherapy. ( Attilakos, A; Garoufi, A; Katsarou, E; Koemtzidou, E; Kossiva, L; Soldatou, A; Tsentidis, C; Vartzelis, G, 2016)
"Although it has been reported that some antiepileptic drugs have inducing or inhibiting effects on lamotrigine (LTG) clearance, whether they have the same effects in Asian epilepsy patients as in those in other countries has not been clarified, especially in children."7.83The effects of co-medications on lamotrigine clearance in Japanese children with epilepsy. ( Abe, S; Azuma, Y; Ishihara, N; Ito, Y; Itomi, K; Kidokoro, H; Kojima, S; Kurahashi, H; Kurahashi, N; Maruyama, K; Natsume, J; Negoro, T; Okumura, A; Suzuki, M; Takeuchi, T; Tsuji, T; Watanabe, K; Yamada, K; Yamamoto, H, 2016)
"The aim of this study was to compare the risk of metabolic syndrome (MS) and evaluate related factors for MS among people with epilepsy treated with valproate (VPA) or carbamazepine (CBZ)."7.83Metabolic syndrome and anticonvulsants: A comparative study of valproic acid and carbamazepine. ( Haldre, S; Kõks, S; Rakitin, A, 2016)
"To identify potential risk factors for the development of subclinical hypothyroidism following long-term valproic acid monotherapy in children with epilepsy."7.83Duration of valproic acid monotherapy correlates with subclinical thyroid dysfunction in children with epilepsy. ( Bogićević, D; Ilić, V; Ješić, M; Kovačević, M; Kovačević, SV; Miljković, B; Prostran, M, 2016)
"Based on data from the EURAP observational International registry of antiepileptic drugs (AEDs) and pregnancy, we assessed changes in seizure control and subsequent AED changes in women who underwent attempts to withdraw valproic acid (VPA) during the first trimester of pregnancy."7.83Withdrawal of valproic acid treatment during pregnancy and seizure outcome: Observations from EURAP. ( Battino, D; Bonizzoni, E; Craig, J; Lindhout, D; Perucca, E; Sabers, A; Thomas, SV; Tomson, T; Vajda, F, 2016)
" Here, we suggest that triggering limbic seizures with low doses of PTZ in pilocarpine-treated marmosets might provide a more effective basis for the development of AED."7.83Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. ( Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM, 2016)
"Valproic acid (VPA) is a widely used antiepileptic drug with acceptable safety and efficacy in treating pediatric patients with various kinds of seizures."7.83Effects of UGT1A6 and GABRA1 on Standardized Valproic Acid Plasma Concentrations and Treatment Effect in Children With Epilepsy in China. ( Fang, F; Feng, W; Gao, B; Mei, S; Wu, X; Yang, W; Yu, Y; Zhao, Z; Zhu, L, 2016)
"Lamotrigine (LTG) is a widely used antiepileptic-drug (AED) for the treatment of epilepsy."7.81Effect of comedication on lamotrigine clearance in Korean epilepsy patients. ( Hong, SB; Joo, EY; Kim, HJ; Kim, TE; Lee, SY; Seo, DW, 2015)
"Stiripentol is an antiepileptic drug (AED) approved by the European Medicines Agency for the treatment of Dravet Syndrome (DS) as adjunct treatment with valproate and clobazam."7.81Extending the use of stiripentol to other epileptic syndromes: a case of PCDH19-related epilepsy. ( Specchio, N; Trivisano, M; Vigevano, F, 2015)
"Carnitine deficiency is relatively common in epilepsy; risk factors reportedly include combination antiepileptic drug (AED) therapy with valproic acid (VPA), young age, intellectual disability, diet and enteral or parenteral feeding."7.81Carnitine deficiency: Risk factors and incidence in children with epilepsy. ( Fukuda, M; Ishii, E; Iwano, S; Kawabe, M; Kikuchi, C; Kuwabara, K; Morimoto, T; Suzuki, Y; Takehara, M; Wakamoto, H, 2015)
"Weight gain is the most frequent adverse effect of valproic acid (VPA) treatment, resulting in poor compliance and many endocrine disturbances."7.81Association of LEPR and ANKK1 Gene Polymorphisms with Weight Gain in Epilepsy Patients Receiving Valproic Acid. ( Chen, X; Chen, Z; Hou, X; Huang, M; Li, H; Li, J; Ni, G; Su, Q; Wang, X; Xie, W; Xin, S; Zhou, L; Zhou, Y, 2015)
"To prospectively evaluate the long-term impact of valproate (VPA) versus carbamazepine (CBZ) on anthropometric, hormonal, and metabolic parameters in young male patients treated for epilepsy."7.81Endocrine Effects of Valproate versus Carbamazepine in Males with Epilepsy: A Prospective Study. ( de Vries, L; Goldberg-Stern, H; Itzhaki, T; Landau, Z, 2015)
"Lamotrigine (LTG) is widely used in the treatment of children with epilepsy."7.81Effects of UGT1A4 genetic polymorphisms on serum lamotrigine concentrations in Chinese children with epilepsy. ( Dong, Y; Guo, Y; Liang, M; Qiu, F; Wang, Q; Yun, W; Zhao, L, 2015)
"The study was conducted on children aged 8-16 years who were undergoing valproic acid monotherapy for epilepsy."7.81An Evaluation of Peripapillary Retinal Nerve Fiber Layer Thickness in Children With Epilepsy Receiving Treatment of Valproic Acid. ( Akçam, M; Dereci, S; Koca, T; Türkyilmaz, K, 2015)
"The aim of this study was to investigate the distribution and frequency of genetic polymorphisms in uridine diphosphate glucuronosyltransferase-2B7 (UGT2B7) in epilepsy patients and to evaluate the effect of these on the metabolism of valproic acid (VPA)."7.81The influence of UGT2B7 genotype on valproic acid pharmacokinetics in Chinese epilepsy patients. ( Huang, HW; Lin, H; Luo, YH; Peng, ZK; Sun, YX; Tang, FQ; Wang, HM; Zhuo, WY, 2015)
"Valproic acid (VPA) is a useful antiepileptic drug for controlling different types of epilepsy."7.81[The prevalence of obesity and metabolic syndrome in paediatric patients with epilepsy treated in monotherapy with valproic acid]. ( Carmona-Vazquez, CR; Diaz-Garcia, L; Greenawalt, SR; Pena-Landin, DM; Ruiz-Garcia, M, 2015)
"To examine the effects of cytochrome P450 3A4 (CYP3A4), cytochrome P450 3A5 (CYP3A5) and ATP-binding cassette sub-family B member 1 (ABCB1) genetic polymorphisms on carbamazepine (CBZ) plasma concentrations in Chinese patients with epilepsy using CBZ as monotherapy and bitherapy with phenytoin (PHT), phenobarbital (PB), or valproic acid (VPA)."7.81Effects of CYP3A4/5 and ABCB1 genetic polymorphisms on carbamazepine metabolism and transport in Chinese patients with epilepsy treated with carbamazepine in monotherapy and bitherapy. ( Liu, DQ; Ma, HY; Sheng, YH; Wang, C; Wang, P; Yin, T; Zhou, BT, 2015)
"Valproic acid (VPA), which is widely used to treat epilepsy, migraine, and bipolar disorder, can causes severe hyperammonemia."7.81Influence of glutamine synthetase gene polymorphisms on the development of hyperammonemia during valproic acid-based therapy. ( Hirai, K; Imai, K; Inoue, K; Inoue, Y; Itoh, K; Suzuki, E; Takahashi, T; Takahashi, Y; Tsuji, D; Yamamoto, Y, 2015)
"Valproic acid (VPA) is widely used to treat various types of epilepsy."7.80Influence of uridine diphosphate glucuronosyltransferase 2B7 -161C>T polymorphism on the concentration of valproic acid in pediatric epilepsy patients. ( Hayashi, H; Imai, K; Inoue, K; Inoue, Y; Itoh, K; Koyama, S; Suzuki, E; Takahashi, T; Takahashi, Y; Tsuji, D; Yamamoto, Y; Yazawa, R, 2014)
"A 12-year-old patient with refractory epilepsy syndrome presented with phenytoin toxicity, following a concomitant treatment with phenytoin, valproic acid, and lamotrigine."7.80Drug interaction between phenytoin and valproic acid in a child with refractory epilepsy: a case report. ( Carnevale, RC; Carvalho, IV; de Fátima Lopes Ambrósio, R; de Queiroz, RA; dos Reis, MC; Mazzola, PG; Moriel, P; Visacri, MB, 2014)
"Lacosamide (LCM), a new antiepileptic drug (AED) approved as adjunctive therapy for the treatment of patients with partial-onset seizures, has limited pharmacokinetic and drug interaction data."7.80Lacosamide serum concentrations in adult patients with epilepsy: the influence of gender, age, dose, and concomitant antiepileptic drugs. ( Duncan, JS; Markoula, S; Patsalos, PN; Ratnaraj, N; Sander, JW; Teotonio, R, 2014)
"The aims of this study were to characterize a lamotrigine-resistant kindled model of epilepsy in mice, to study the anticonvulsant effect of carbamazepine (CBZ) and valproic acid (VPA), and to probe into the mechanism for resistance."7.80Characterization of a lamotrigine-resistant kindled model of epilepsy in mice: evaluation of drug resistance mechanisms. ( Mehndiratta, M; Pillai, KK; Singh, E, 2014)
"Valproic acid, a branched short-chain fatty acid, has numerous action mechanisms which turn it into a broad spectrum anticonvulsant drug and make its use possible in some other pathologies such as bipolar disorder."7.80Hyperammonemia associated with valproic acid concentrations. ( Alvariza, S; Fagiolino, P; Guevara, N; Ibarra, M; Magallanes, L; Maldonado, C; Olano, I; Olmos, I; Vázquez, M, 2014)
"Valproic acid, which is widely used to treat various types of epilepsy, may cause severe hyperammonemia."7.804217C>A polymorphism in carbamoyl-phosphate synthase 1 gene may not associate with hyperammonemia development during valproic acid-based therapy. ( Hayashi, H; Imai, K; Inoue, K; Inoue, Y; Itoh, K; Miyakawa, K; Suzuki, E; Takahashi, T; Takahashi, Y; Tsuji, D; Yamamoto, Y; Yazawa, R, 2014)
"To investigate biochemical cardiovascular risk factors and vascular endothelial function and structure in children with epilepsy on antiepileptic drugs (AEDs), particularly sodium valproate (VPA) and carbamazepine (CBZ)."7.80Vascular function and risk factors in children with epilepsy: associations with sodium valproate and carbamazepine. ( Keenan, N; Sadlier, LG; Wiltshire, E, 2014)
"Hyperammonemia has been reported to be associated with patients who receive valproic acid (VPA) therapy."7.80Risk factors of hyperammonemia in patients with epilepsy under valproic acid therapy. ( Chang, CC; Chang, WN; Chen, NC; Chuang, YC; Huang, CR; Lin, CH; Lu, CH; Lu, YT; Tseng, YL, 2014)
"To facilitate therapeutic monitoring of antiepileptic drugs (AEDs) by healthcare professionals for patients with epilepsy (PWE), we applied a GC-MS assay to measure three AEDs: carbamazepine (CBZ), phenytoin (PHT) and valproic acid (VPA) levels concurrently in one dried blood spot (DBS), and validated the DBS-measured levels to their plasma levels."7.80Clinical validation and implications of dried blood spot sampling of carbamazepine, valproic acid and phenytoin in patients with epilepsy. ( Ho, PC; Kong, ST; Kumar, PK; Lee, WB; Lim, SH; Ng, YL; Wang, HY; Wong, PS, 2014)
"The combination of lamotrigine and valproate/divalproex sodium has been shown to be effective in the treatment of refractory epilepsy."7.79Valproate and lamotrigine in pediatric patients with refractory epilepsy: after the first year. ( Thome-Souza, S; Valente, KD, 2013)
"Our findings suggest that the UGT1A6 (552A>C) genetic polymorphism plays a significant role in the steady state concentration of valproic acid, and it thereby has an impact on the toxicity of the valproic acid used in the patients with epilepsy."7.79The effect of uridine diphosphate glucuronosyltransferase (UGT)1A6 genetic polymorphism on valproic acid pharmacokinetics in Indian patients with epilepsy: a pharmacogenetic approach. ( Arumugam, K; Behari, M; Jain, DC; Mallayasamy, SR; Munisamy, M; Raghavan, S; Rajakannan, T; Ramanujam, B; Subbiah, V; Tripathi, M, 2013)
" We investigated the effects of valproic acid and topiramate on the levels of insulin, c-peptide and adipocytokines in pre-pubertal patients with idiopathic partial and generalized epilepsy."7.79The effects of topiramate and valproate therapy on insulin, c-peptide, leptin, neuropeptide Y, adiponectin, visfatin, and resistin levels in children with epilepsy. ( Aksoy, A; Aliyazicioglu, R; Deger, O; Fazlioglu, K; Karaguzel, G; Sonmez, FM; Zaman, D, 2013)
" (MQ) in maximal electroshock (MES) and pentylenetetrazole (PTZ) induced rat models of epilepsy."7.79Evaluation of anti-epileptic property of Marsilea quadrifolia Linn. in maximal electroshock and pentylenetetrazole-induced rat models of epilepsy. ( Avinash, H; Chandrashekar, BR; Mukunda, N; Naduvil Narayanan, S; Nayak, BS; Raghavendra Rao, K; Sadhana, N; Satish Kumar, MC; Snehunsu, A; Vijay Kapgal, K, 2013)
"We studied 107 patients with epilepsy who received monotherapy with valproic acid drugs (58) and carbamazepine (49)."7.79[Season fluctuations of carbamazepine and valproate concentration in patients with epilepsy]. ( Avakian, GG; Avakian, GN; Bogomazova, MA; Delger, AB; Khromykh, EA; Lagutin, IuV; Oleĭnikova, OM, 2013)
"The participants included 53 epilepsy patients who received either valproic acid (VPA, n=26) or oxcarbazepine (OXC, n=27)."7.79Assessment of atherosclerosis risk due to the homocysteine-asymmetric dimethylarginine-nitric oxide cascade in children taking antiepileptic drugs. ( Arga, M; Arhan, E; Biberoglu, G; Cansu, A; Emeksiz, HC; Gulbahar, O; Hasanoglu, A; Serdaroglu, A, 2013)
"Valproic acid (VPA) is a well-established anticonvulsant drug that has been increasingly used in the treatment of many forms of generalized epilepsy."7.78Simultaneous determination of valproic acid and 2-propyl-4-pentenoic acid for the prediction of clinical adverse effects in Chinese patients with epilepsy. ( Chen, SD; Chen, ZJ; Fang, ZY; Huang, M; Li, JL; Shu, WY; Wang, HS; Wang, XD; Zhang, Y; Zhou, JQ; Zhou, LM, 2012)
"The aim of this study was to investigate the genetic polymorphisms of UGT1A3, UGT1A6, and UGT2B7 in Chinese epilepsy patients and their potential influence on the pharmacokinetics of valproic acid (VPA)."7.78Influence of UDP-glucuronosyltransferase polymorphisms on valproic acid pharmacokinetics in Chinese epilepsy patients. ( Chu, XM; Hao, HP; Wang, GJ; Zhang, LF; Zhang, SN; Zhou, JH, 2012)
"Hyperammonemia is one of the side effects of treatment with valproic acid (VPA), but the risk factors and mechanisms involved remain obscure."7.78Risk factors for hyperammonemia associated with valproic acid therapy in adult epilepsy patients. ( Inoue, K; Inoue, Y; Itoh, K; Kagawa, Y; Mishima, N; Suzuki, E; Takahashi, Y; Yamamoto, Y, 2012)
"The aim of this study was to evaluate the incidence of thyroid dysfunction during valproic acid (VPA) therapy in children and adolescents with epilepsy."7.78Subclinical hypothyroidism during valproic acid therapy in children and adolescents with epilepsy. ( Chae, JH; Chung, HR; Hwang, H; Hwang, YS; Kim, H; Kim, KJ; Kim, SH; Lim, BC, 2012)
"We report 2 children with a history of epilepsy in whom valproic acid (VPA) withdrawal was identified as a potential cause of hallucinations."7.78Hallucinations after withdrawal of valproic acid. ( Braun, KP; de Graeff-Meeder, ER; de Laat, SA; Hillegers, MH; Jansen, FE, 2012)
"We examined the influence of age and type of concomitant antiepileptic drugs (AEDs) on the pharmacokinetics of rufinamide (RUF) as well as its efficacy and safety in 51 children with refractory epilepsy."7.78Rufinamide in children with refractory epilepsy: pharmacokinetics, efficacy, and safety. ( Dahlin, MG; Ohman, I, 2012)
"Valproic acid (VPA) is one of the most commonly prescribed drugs for the treatment of epilepsy."7.78Effects of UGT1A6, UGT2B7, and CYP2C9 genotypes on plasma concentrations of valproic acid in Chinese children with epilepsy. ( Guo, Y; He, X; Hu, C; Qiu, F; Zhao, L, 2012)
"An open pilot study to evaluate the effect of pregabalin (PGB) as add-on therapy on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy (BTRE)."7.78Effect of pregabalin add-on treatment on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy: a pilot study. ( Carapella, CM; Dinapoli, L; Fabi, A; Maschio, M; Pace, A; Pompili, A; Sperati, F; Vidiri, A, 2012)
"Weight gain is a well-known unwanted effect of valproic acid (VPA) therapy."7.77Circulating levels of allopregnanolone, a neuroactive steroid, and leptin during treatment with valproic acid in children with epilepsy. ( Balestri, P; Barlocco, EG; Casarosa, E; Grosso, S; Luisi, S; Matera, M; Mostardini, R; Petraglia, F, 2011)
"Patients treated with valproic acid (VPA) present a high incidence of non-alcoholic fatty liver disease (NAFLD) (around 61%)."7.77A preliminary investigation on the possible association between diminished copper availability and non-alcoholic fatty liver disease in epileptic patients treated with valproic acid. ( Lampon, N; Tutor, JC, 2011)
"This study aims to investigate the alteration of iron homeostasis and oxidative stress status in epilepsy patients treated with valproic acid (VPA) monotherapy."7.77Increase in non-transferrin bound iron and the oxidative stress status in epilepsy patients treated using valproic acid monotherapy. ( Atroshi, F; Fucharoen, S; Kaipainen, P; Kaski, M; Ounjaijean, S; Partinen, M; Plonka-Poltorak, E; Srichairatanakool, S; Westermarck, T, 2011)
"Lamotrigine (LTG) which has a widespread use in epilepsy treatment as an antiepileptic agent is metabolized by UDP-glucuronosyl transferase (UGT) enzymes."7.77The relationship between UGT1A4 polymorphism and serum concentration of lamotrigine in patients with epilepsy. ( Aker, RG; Goren, MZ; Gulcebi, MI; Onat, FY; Ozkara, C; Ozkaynakcı, A, 2011)
"The aim of this study was to establish the population protein binding parameters of valproic acid (VPA) in patients with epilepsy receiving VPA monotherapy and those receiving VPA combined with other antiepileptic drugs."7.77No effect of co-administered antiepileptic drugs on in-vivo protein binding parameters of valproic acid in patients with epilepsy. ( Abe, T; Itoh, H; Nishimura, F; Sato, Y; Suzuki, Y; Takeyama, M, 2011)
"We investigated the effect of lamotrigine (LTG) add-on therapy in 50 patients with childhood-onset refractory epilepsy (25 males and 25 females): 15 with localization-related epilepsy, 33 with generalized epilepsy, and 2 with undetermined epilepsy."7.77[Lamotrigine add-on therapy for childhood-onset refractory epilepsy: comparison of the efficacy between 3 months and 6 months after initiation]. ( Endoh, F; Kobayashi, K; Ohtsuka, Y; Watanabe, K; Yoshinaga, H, 2011)
" Patients with clinically stable partial or generalized epilepsy, already receiving lamotrigine or valproic acid on monotherapy, were assessed in two visits: baseline and at 6 months."7.76Quality of life and treatment satisfaction in Spanish epilepsy patients on monotherapy with lamotrigine or valproic acid. ( Barriga, J; Cobaleda, S; Codina, M; Lahuerta, J; Morales, MD; Viteri, C, 2010)
"Lamotrigine (LTG) is increasingly being prescribed in pregnancy for women with epilepsy in place of valproate (VPA), because of the teratogenic risks associated with the latter."7.76Is lamotrigine a significant human teratogen? Observations from the Australian Pregnancy Register. ( Eadie, MJ; Graham, JE; Hitchcock, AA; Lander, CM; O'Brien, TJ; Vajda, FJ, 2010)
" In utero, exposure to valproic acid (VPA) and phenytoin (PH) may cause congenital malformations and also withdrawal symptoms such as irritability, jitteriness and symptoms of hypoglycemia."7.76Neonatal episodic hypoglycemia: a finding of valproic acid withdrawal. ( Akçakuş, M; Akın, MA; Çoban, D; Güneş, T; Kurtoğlu, S, 2010)
"We evaluated the serum leptin and insulin as predictors of weight gain in children receiving long-term treatment with valproate (VPA), carbamazepine (CBZ), lamotrigine (LTG)."7.75States of serum leptin and insulin in children with epilepsy: risk predictors of weight gain. ( Fida, NM; Hamed, EA; Hamed, SA, 2009)
"Valproic acid-associated weight gain may occur in young children."7.75Body mass index and serum lipid changes during treatment with valproic acid in children with epilepsy. ( Balestri, P; Grosso, S; Mostardini, R; Piccini, B, 2009)
"The long-term effects of valproic acid (VPA) on reproductive endocrine functions in women with epilepsy (WWE) were studied."7.75Long-term effects of valproic acid on reproductive endocrine functions in Turkish women with epilepsy. ( Dogan, EA; Genc, BO; Genc, E; Gorkemli, H; Ozdemir, S, 2009)
"The aim of this study is to evaluate the erythrocyte lipid peroxidation and antioxidant enzyme levels in patients with newly diagnosed idiopathic epilepsy before treatment and in patients treated with valproic acid for idiopathic epilepsy."7.75Effects of epilepsy and valproic acid on oxidant status in children with idiopathic epilepsy. ( Dirik, E; Kuralay, F; Kurul, SH; Seçkin, E; Yiş, U, 2009)
" This retrospective study of children with epilepsy, aged <12 years at enrollment, examined weight gain associated with valproic acid or carbamazepine monotherapy."7.74Lack of valproic acid-associated weight gain in prepubertal children. ( Baumann, RJ; Espinosa, PS; Mendiondo, MS; Robertson, WC; Salazar, JC; Yu, L, 2008)
"To determine the influence of valproate (VPA) treatment on acylcarnitines in children with epilepsy."7.74Effects of valproate on acylcarnitines in children with epilepsy using ESI-MS/MS. ( Gerstner, T; Koenig, SA; Kohlmueller, D; Longin, E; Mehlem, P; Schulze, A; Teich, M; Treiss, I; Werner, T, 2007)
"Ecto-nucleotidases, one of the main mechanisms involved in the control of adenosine levels in the synaptic cleft, have shown increased activities after the pilocarpine model of epilepsy."7.74Antiepileptic drugs prevent changes induced by pilocarpine model of epilepsy in brain ecto-nucleotidases. ( Bogo, MR; Bonan, CD; Bruno, AN; Cognato, Gde P; da Silva, RS; Sarkis, JJ, 2007)
"Hypospadias is one of the most frequently occurring genital anomalies described in infants prenatally exposed to valproic acid (VA)."7.74Risk of hypospadias in newborn infants exposed to valproic acid during the first trimester of pregnancy: a case-control study in Spain. ( Fernández, P; Martínez-Frías, ML; Mejías, C; Prieto-Merino, D; Rodríguez-Pinilla, E, 2008)
"The aim of our study was to investigate whether a correlation exists between steady-state serum concentration of valproic acid and quality of life in adolescent patients with epilepsy."7.74Inverse correlation of valproic acid serum concentrations and quality of life in adolescents with epilepsy. ( Jakovljevic, MB; Jankovic, SM; Jankovic, SV; Todorovic, N, 2008)
" The combination of AGLD (5 mg/kg) with phenobarbital (PB, applied at its subeffective dose of 15 mg/kg) significantly shortened motor seizure and afterdischarge duration in amygdala-kindled seizures."7.73Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats. ( Borowicz, KK; Czuczwar, SJ, 2005)
"To report a probable interaction between meropenem and valproic acid that resulted in the development of epileptic seizures."7.73Acute seizures due to a probable interaction between valproic acid and meropenem. ( Borrás-Blasco, J; Coves-Orts, FJ; Murcia-López, A; Navarro-Ruiz, A; Palacios-Ortega, F, 2005)
" However, he was found to have hyperammonemia within 2 weeks after the addition of low-dose topiramate to valproate."7.73Topiramate-valproate-induced hyperammonemic encephalopathy syndrome: case report. ( Cheung, E; Fung, CW; Wong, V, 2005)
"This study evaluated the effect of the addition of zonisamide on valproic acid (valproate sodium) pharmacokinetics under steady-state conditions in patients with epilepsy."7.73Lack of pharmacokinetic interactions between steady-state zonisamide and valproic acid in patients with epilepsy. ( Brodie, M; Grundy, JS; Levy, RH; Ragueneau-Majlessi, I; Shah, J; Smith, D, 2005)
"To evaluate whether the administration of lamotrigine (LTG) or valproate (VPA) changes concentrations of plasma total homocysteine (tHcy), plasma and red-cell folate and plasma Vitamin B-12, we measured these indices in a total of 20 patients with epilepsy before and after a 32-week period of monotherapy of LTG or VPA."7.73Blood homocysteine, folate and vitamin B-12 concentrations in patients with epilepsy receiving lamotrigine or sodium valproate for initial monotherapy. ( Gidal, BE; Hammer, A; Tamura, T; Vuong, A, 2005)
"Valproic acid has been widely used for the treatment of epilepsy."7.73[Hyperammonemia secondary to the use of valproic acid: case report]. ( Fernandes, RM; Funayama, CA; Turcato, Mde F; Wichert-Ana, L, 2005)
"The aim of the study was to obtain pharmacokinetic data for carbamazepine (CBZ) and its fractions not bound with proteins in bitherapy with lamotrigine (LTG), topiramate (TPM), vigabatrin (VGB) or valproic acid (VPA) in children and adolescents treated for epilepsy."7.73Pharmacokinetic interactions of carbamazepine with some antiepileptic drugs during epilepsy treatment in children and adolescents. ( Steinborn, B, 2005)
"Authors presented the data on the efficacy and tolerability of the new anticonvulsant drug topiramate (topamax) in the treatment of 110 children aged from 6 months to 16 years with pharmacoresistant types of epilepsy including 42 patients with tuberous sclerosis."7.73[The efficacy of topiramate (topamax) in the treatment of resistant epilepsy in children]. ( Belousova, ED; Dorofeeva, MIu; Ermakov, AIu, 2005)
") continuous valproic acid (VPA) infusion, as compared with acute injections in the kindling epilepsy model."7.73Effect of intracerebroventricular continuous infusion of valproic acid versus single i.p. and i.c.v. injections in the amygdala kindling epilepsy model. ( Alós, M; Barcia, JA; Durán, C; Hernández, ME; Ortiz, P; Serralta, A, 2006)
" The mother had been treated with valproic acid (1800mg per day) and lamotrigine (100mg per day) throughout pregnancy."7.72Valproic acid and lamotrigine treatment during pregnancy. The risk of chromosomal abnormality. ( Cogulu, O; Gunduz, C; Kultursay, N; Ozkinay, F; Yilmaz, D, 2003)
"This open-label, cross-sectional study compared (1) endocrine and lipid measures during the early follicular phase of the menstrual cycle; (2) prevalence of menstrual disorders (from patient diaries recorded over three cycles); and (3) body weight of women with epilepsy on lamotrigine monotherapy (n=119) with those on valproate monotherapy (n=103) for <5 years."7.72Higher androgens and weight gain with valproate compared with lamotrigine for epilepsy. ( Ayala, R; Dam, M; Gomez, G; Isojärvi, J; Messenheimer, J; Morrell, MJ; O'Neill, F; Taylor, AE; Tennis, P, 2003)
"A 5-year-old female developed alteration of consciousness during 3 days of long-term treatment with valproic acid for localization-related epilepsy."7.72Reversible altered consciousness with brain atrophy caused by valproic acid. ( Eguchi, M; Imataka, G; Nakagawa, E; Ota, T; Yamanouchi, H, 2003)
"Two months-old girl with psychomotor retardation had aminophylline-resistant apnea attacks and was investigated by video-EEG recording."7.72[A case of infantile epileptic apnea with congenital brain anomaly]. ( Hamano, K; Iwasaki, N; Matsui, A; Ohto, T; Takahashi, M; Tanaka, R, 2003)
"A 70-year-old woman under anticonvulsive therapy with carbamazepine and valproate was diagnosed as polymyalgia rheumatica."7.72[A case of polymyalgia rheumatica with improved steroid-responsibility after discontinuing carbamazepine]. ( Katada, S; Kobayashi, H; Sato, A; Sato, M, 2004)
"To investigate the possible role of valproic acid therapy in the development of the weight gain and hyperinsulinemia of epileptic patients."7.72[Insulin resistance in epileptic patients during treatment of valproic acid]. ( Bao, YY; Chen, Z; Ding, MP; Liu, ZR; Xu, LL, 2004)
"In the past 6 years, 11 children on valproic acid have developed pancreatitis in our children's hospital."7.72Valproic acid-induced pancreatitis in childhood epilepsy: case series and review. ( Berg, M; Breault, R; Sinclair, DB, 2004)
"In order to investigate the possible role of valproic acid therapy in the development of obesity, hyperinsulinism and polycystic ovaries (PCOs), we have studied metabolic parameters and ovarian morphology in epileptic women."7.71Polycystic ovaries, obesity and insulin resistance in women with epilepsy. A comparative study of carbamazepine and valproic acid in 105 women. ( Abraham, I; Alge, A; Bauer, G; Haslinger, M; Lechleitner, M; Luef, G; Seppi, K; Trinka, E; Unterberger, I; Windisch, J, 2002)
"A 15-year-old boy with epilepsy and cerebral calcifications, treated with valproic acid, ethyl phenylbarbiturate and ethosuximide, was referred for drug induced systemic lupus erythematosus."7.71Latent coeliac disease in a child with epilepsy, cerebral calcifications, drug-induced systemic lupus erythematosus and intestinal folic acid malabsorption associated with impairment of folic acid transport across the blood-brain barrier. ( Calvani, M; Guaitolini, C; Paolone, G; Parisi, G; Parisi, P, 2001)
"It is not known whether polytherapy with carbamazepine (CBZ) and valproate (VPA) increases the risk of thrombocytopenia."7.71Severe, isolated thrombocytopenia under polytherapy with carbamazepine and valproate. ( Finsterer, J; Hess, B; Pelzl, G, 2001)
" This study aimed to evaluate thyroid function in men taking carbamazepine (CBZ), oxcarbazepine (OCBZ), or valproate (VPA) for epilepsy."7.71Thyroid function in men taking carbamazepine, oxcarbazepine, or valproate for epilepsy. ( Isojärvi, JI; Kotila, M; Myllylä, VV; Pakarinen, AJ; Rättyä, J; Turkka, J, 2001)
"To determine whether long-term treatment with valproate (VPA) and/or lamotrigine (LTG) in children with epilepsy is associated with altered growth and/or bone metabolism."7.71Long-term valproate and lamotrigine treatment may be a marker for reduced growth and bone mass in children with epilepsy. ( Atkinson, SA; Guo, CY; Ronen, GM, 2001)
"Dynamics of carbamazepine and valproic acid concentrations in the middle of follicular and lutein menstrual cycle phases has been studied in women with epilepsy, aged 21-30 years."7.71[Pharmacokinetic aspects of carbamazepine and valproic acid using in reproductive-age women with epilepsy]. ( Karlov, VA; Sokolov, AV; Tishchenkova, IF; Vlasov, PN, 2002)
" Leptin is considered a signaling factor regulating body weight and energy metabolism."7.71Serum insulin and leptin levels in valproate-associated obesity. ( Isojärvi, JI; Knip, M; Kotila, M; Pakarinen, A; Pylvänen, V; Turkka, J, 2002)
"Valproic acid is effective for treatment of many types of epilepsy, but its use in epileptic patients can be associated with an increase in body weight that could interfere with treatment compliance."7.71Insulin resistance in epileptic girls who gain weight after therapy with valproic acid. ( Basciani, F; Chiarelli, F; De Simone, M; Morgese, G; Trotta, D; Verrotti, A, 2002)
"In November 1996, a panel of pediatric neurologists met to update the consensus statement issued in 1989 by a panel of neurologists and metabolic experts on L-carnitine supplementation in childhood epilepsy."7.70L-carnitine supplementation in childhood epilepsy: current perspectives. ( Bohan, TP; Coulter, DL; De Vivo, DC; Dreifuss, FE; Greenwood, RS; Nordli, DR; Shields, WD; Stafstrom, CE; Tein, I, 1998)
"Forty girls taking valproate (VPA), 19 girls taking carbamazepine (CBZ), and 18 girls taking oxcarbazepine (OXC) for epilepsy and 49 healthy control girls participated in the study, which included a cross-sectional clinical examination when the girls were 8 to 18 years old and a longitudinal growth analysis from the age of 1 year."7.70The effects of valproate, carbamazepine, and oxcarbazepine on growth and sexual maturation in girls with epilepsy. ( Isojärvi, JI; Knip, M; Lanning, P; Rättyä, J; Vainionpää, L, 1999)
"Neural tube defects (NTDs) are the most common of the major anomalies associated with in utero exposure to valproic acid."7.70Safe use of valproic acid during pregnancy. ( Kennedy, D; Koren, G, 1999)
"We previously encountered a patient with epilepsy who exhibited rapid elimination of sustained-release valproic acid (VPA) administered at the dose of 2."7.70Valproic acid elimination rate and urinary excretion of its glucuronide conjugate in patients with epilepsy. ( Akiyama, T; Hayashi, T; Hirozane, K; Kamiya, A; Katayama, H; Kimoto, H; Watanabe, M; Yoshida, H; Yoshitomi, H, 1999)
"We determined serum levels of triiodothyronine (T3), thyroxine (T4), free thyroxine (FT4), thyroxine-binding globulin (TBG), and thyroid-stimulating hormone (TSH) in 148 healthy children and 141 children with epilepsy who had been receiving CBZ (61 patients), VPA (51 patients), or PB (29 patients) for 12-161 months."7.70Long-term treatment of children with epilepsy with valproate or carbamazepine may cause subclinical hypothyroidism. ( Castro-Gago, M; Del Río-Garma, M; Del Río-Garma, MC; Eirís-Puñal, J; Lojo-Rocamonde, S; Novo-Rodríguez, I, 1999)
"Perimenstrual catamenial epilepsy, the exacerbation of seizures in association with menstruation, may in part be due to withdrawal of the progesterone metabolite allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one), an endogenous anticonvulsant neurosteroid that is a positive allosteric modulator of gamma-aminobutyric acid(A) receptors."7.70Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy. ( Reddy, DS; Rogawski, MA, 2000)
"The interaction between clearance of phenytoin, valproic acid, phenobarbital and carbamazepine, and changes in body weight was determined in a 19-year-old obese woman with epilepsy (body weight 93 kg, BMI 36."7.69Clearance of phenytoin and valproic acid is affected by a small body weight reduction in an epileptic obese patient: a case study. ( Ashikari, Y; Chiba, S; Kodama, Y; Kuranari, M; Sakata, T; Takeyama, M, 1996)
"This study was performed to evaluate the aggregation changes in the whole blood samples of children with epilepsy receiving valproic acid."7.69The platelet aggregation in children with epilepsy receiving valproic acid. ( Akin, R; Gokcay, E; Koseoglu, V; Kurekci, AE; Ozcan, O; Tanindi, S, 1996)
"Twelve women receiving stable valproic acid (VPA) monotherapy for epilepsy received a combination norethindrone 1."7.69Effect of topiramate on the pharmacokinetics of an oral contraceptive containing norethindrone and ethinyl estradiol in patients with epilepsy. ( Doose, DR; Nayak, RK; Rosenfeld, WE; Walker, SA, 1997)
"Very little data are available on the usefulness of oxcarbazepine in young children with epilepsy."7.69Oxcarbazepine in the treatment of early childhood epilepsy. ( Gaily, E; Granström, ML; Liukkonen, E, 1997)
"Information from standardised tests of intelligence, school attainments, attention, memory and visuomotor function, together with parent and teacher questionnaire information about various aspects of behaviour, was obtained for 63 schoolchildren with newly diagnosed epilepsy before treatment with sodium valproate or carbamazepine, and again at intervals for a total period of 12 months."7.68Psychological effects of sodium valproate and carbamazepine in epilepsy. ( Stores, G; Styles, E; Williams, PL; Zaiwalla, Z, 1992)
"We retrospectively collected plasma level assessments performed in 96 adult patients with epilepsy on stable monotherapy, including 9 patients on clobazam (CLB), 34 on carbamazepine (CBZ), 24 on phenobarbital (PB), 9 on phenytoin (PHT), and 20 on valproate (VPA); these results were compared to those obtained in 54 adult patients on stable bitherapy with the association of CLB with either CBZ (n = 17), PB (n = 17), PHT (n = 5), or VPA (n = 15)."7.68Interactions between clobazam and standard antiepileptic drugs in patients with epilepsy. ( Bonneton, J; Dravet, C; Genton, P; Mesdjian, E; Roger, J; Sennoune, S, 1992)
"The anticonvulsant potency of 2-propyl-2-pentenoic acid (2-en-VPA; trans isomer), a major metabolite of the antiepileptic valproic acid (VPA), was evaluated in different animal models of epilepsy and compared with the respective data for VPA."7.67Comparative evaluation of anticonvulsant and toxic potencies of valproic acid and 2-en-valproic acid in different animal models of epilepsy. ( Löscher, W; Marescaux, C; Nau, H; Vergnes, M, 1984)
"A total of 64 problem patients with epilepsy (42 retrospective evaluations, 22 prospective cases) was treated with the combination of carbamazepine and valproic acid."7.67[Combination therapy with carbamazepine and valproic acid in problem cases at an outpatient epilepsy clinic]. ( Fröscher, W; Hoffmann, F; Stoll, KD, 1984)
"Ninety children with epilepsy were treated with carbamazepine (CBZ) alone or with other anticonvulsant drugs."7.67Correlation between plasma carbamazepine-10,11-epoxide concentration and drug side-effects in children with epilepsy. ( Brett, EM; Elyas, AA; Lascelles, PT; Schoeman, JF, 1984)
"We studied 85 pediatric patients with different types of epilepsy treated with valproic acid."7.67Valproic acid in the treatment of epilepsy during the pediatric age. ( Olmos-Garcia de Alba, G; Valdez, JM, 1986)
"To assess the most efficient means of monitoring thyroid status in an epilepsy clinic, total thyroxine (T4), free thyroxine stimulating hormone (TSH) were measured in 71 adult patients treated long-term with either phenytoin (DPH), carbamazepine (CBZ) or sodium valproate (VAL)."7.67The effective evaluation of thyroid status in patients on phenytoin, carbamazepine or sodium valproate attending an epilepsy clinic. ( Borsey, DQ; Browning, MC; Connacher, AA; Davidson, DL; Jung, RT, 1987)
"The problem of phenytoin-induced gingival hyperplasia is dicussed within the context of consultative planning between oral care practitioners and the physician managing the epilepsy."7.66Therapeutic alternatives in phenytoin-induced gingival hyperplasia. A case report and discussion. ( Kirkham, DB; Reynolds, NC, 1980)
"Sodium valproate is often used with phenytoin when epilepsy cannot be controlled by a single drug."7.66Phenytoin-valproate interaction: importance of saliva monitoring in epilepsy. ( Hamshaw-Thomas, A; Knott, C; Reynolds, F, 1982)
"During the course of a prospective serial study over a period of one year, findings compatible with immune-mediated thrombocytolysis accompanied the administration of valproic acid in about half of 45 children with epilepsy."7.66Valproic acid and immune thrombocytopenia. ( Barr, RD; Copeland, SA; Kelton, JC; Morris, N; Stockwell, ML, 1982)
"The authors studied antipyrine disposition before and after delivery in 4 epileptic women whose anticonvulsant plasma level per dosage ratio was lowered during pregnancy, and compared the results to those found in nonpregnant women undergoing antiepileptic treatment (N = 6) and healthy women (N = 6)."7.66Antipyrine disposition in relation to lowered anticonvulsant plasma level during pregnancy. ( Chiba, K; Ishizaki, T; Nakazawa, Y; Tabuchi, T; Wagatsuma, T, 1982)
"Of 88 patients with intractable epilepsy, 60 have been treated with clonazepam for up to three years and 60 have been treated with sodium valproate for up to 18 months."7.65Sodium valproate and clonazepam in the treatment of intractable epilepsy. ( Anthony, M; Lance, JW, 1977)
"This study reviewed all published valproic acid (VPA) population pharmacokinetic (PPK) models in adult patients and assessed them using external validation methods to determine predictive performance."6.82Published population pharmacokinetic models of valproic acid in adult patients: a systematic review and external validation in a Chinese sample of inpatients with bipolar disorder. ( de Leon, J; Dong, F; Guo, W; Li, AN; Ruan, CJ; Zang, YN, 2022)
"Although generalized convulsive status epilepticus (GCSE) is a life-threatening emergency, evidence-based data to guide initial drug treatment choices are lacking in the Chinese population."6.82Phenobarbital Versus Valproate for Generalized Convulsive Status Epilepticus in Adults: A Prospective Randomized Controlled Trial in China. ( Chen, W; Chun, B; Gao, D; Jiang, M; Liu, G; Ren, G; Su, Y; Tian, F; Ye, H; Zhang, Y, 2016)
" The validity of this approach remains uncertain and could be improved by understanding sources of pharmacokinetic variability."6.77Population pharmacokinetics of valproic acid in pediatric patients with epilepsy: considerations for dosing spinal muscular atrophy patients. ( Barrett, JS; Jayaraman, B; Swoboda, KJ; Williams, JH, 2012)
"No patient in the VPA group developed respiratory depression, hypotension, or hepatic dysfunction, whereas in the DZP group, 5."6.76Valproate versus diazepam for generalized convulsive status epilepticus: a pilot study. ( Chen, WB; Fan, CQ; Gao, R; Ren, Y; Su, YY; Wang, L; Zhang, YZ; Zhao, JW, 2011)
"Valproic acid is a widely used anticonvulsant drug with a broad therapeutic spectrum."6.73Inhibitory effect of valproic acid on cytochrome P450 2C9 activity in epilepsy patients. ( Babaoglu, MO; Bilir, E; Bozkurt, A; Gunes, A; Yasar, U; Zengil, H, 2007)
" The DFL for divalproex-ER dosed as a q12h regimen was 22% less than that for once-daily divalproex-ER (P=0."6.72Every-12-hour administration of extended-release divalproex in patients with epilepsy: impact on plasma valproic acid concentrations. ( Cavanaugh, JH; Dutta, S; Granneman, GR; Locke, C; Reed, RC, 2006)
" Patients were converted during an 6.71Lamotrigine monotherapy compared with carbamazepine, phenytoin, or valproate monotherapy in patients with epilepsy. ( Hammer, AE; Kaminow, L; Schimschock, JR; Vuong, A, 2003)
" Pharmacokinetic parameters were determined by a noncompartmental method."6.71Topiramate pharmacokinetics in children with epilepsy aged from 6 months to 4 years. ( Bouhours, P; Chiron, C; d'Athis, P; Dulac, O; Echenne, B; Grinspan, A; Mikaeloff, Y; Pons, G; Rey, E; Soufflet, C; Vallée, L, 2004)
" The peak concentration (Cmax) of CZP and the time intervals from dosing to Cmax (Tmax) were 20."6.70Pharmacokinetic and pharmacodynamic effects of clonazepam in children with epilepsy treated with valproate: a preliminary study. ( Wang, L; Wang, XD, 2002)
"Lamotrigine was effective in all seizure types examined, particularly for typical and atypical absence seizures."6.68Lamotrigine for the treatment of epilepsy in childhood. ( Alving, J; Besag, FM; Dulac, O; Hosking, G; Spencer, SC; Wallace, SJ, 1995)
" Furthermore, we sought to evaluate whether a relationship existed between VPA dosage and plasma clearance for both total and unbound or free drug."6.68Relationship between valproic acid dosage, plasma concentration and clearance in adult monotherapy patients with epilepsy. ( Gidal, BE; Maly, MM; Pitterle, ME; Spencer, NW, 1995)
" The median elimination half-life (t1/2) in patients receiving concomitant valproate (VPA) was 43."6.68Pharmacokinetic interactions between lamotrigine and other antiepileptic drugs in children with intractable epilepsy. ( Boreus, L; Eriksson, AS; Hoppu, K; Nergårdh, A, 1996)
"The steady-state pharmacokinetics of valproate (VPA) and topiramate (TPM) were compared during VPA monotherapy, concomitant VPA and TPM therapy, and TPM monotherapy to evaluate pharmacokinetic interactions."6.68Comparison of the steady-state pharmacokinetics of topiramate and valproate in patients with epilepsy during monotherapy and concomitant therapy. ( Anderson, G; Kramer, LD; Levy, RH; Liao, S; Nayak, RK; Palmer, M; Rosenfeld, WE, 1997)
" In the dosage used, l-tryptophan was tolerated well by these children, and seizure frequency, as a whole, remained unaltered."6.65l-Tryptophan in hyperactive child syndrome associated with epilepsy: a controlled study. ( Ghose, K, 1983)
"Phenytoin has been widely prescribed alone; our results indicate that sodium valproate may also be used as a single drug in the treatment of several types of epilepsy."6.65Comparison of sodium valproate and phenytoin as single drug treatment in epilepsy. ( Johnson, RH; Lambie, DG; Melville, ID; Nanda, RN; Shakir, RA, 1981)
"Valproic acid (VPA) is a commonly used antiepileptic drug (AED)."6.61Valproic acid and Stevens-Johnson syndrome: a systematic review of descriptive studies. ( Kashyap, A; Rashid, M; Undela, K, 2019)
"Phenobarbital was associated with a higher rate of drug withdrawal although there was no evidence to suggest that phenobarbital caused more adverse events compared to carbamazepine, valproic acid or phenytoin."6.47Side effects of phenobarbital in epilepsy: a systematic review. ( Li, YP; Zeng, LN; Zhang, LL, 2011)
"When treatment with valproic acid is the most appropriate treatment to achieve optimal seizure control, a number of measures can be implemented to minimise risk to the fetus."6.43Valproic acid in epilepsy : pregnancy-related issues. ( Genton, P; Semah, F; Trinka, E, 2006)
"Epilepsy is a common medical problem and many studies have demonstrated that infants of women with epilepsy (WWE) have a two to threefold higher risk of congenital malformations compared with the background population."6.43Recent advances on neural tube defects with special reference to Valproic Acid. ( Chiarelli, F; Latini, G; Pelliccia, P; Tana, M; Verrotti, A, 2006)
"Valproic acid is a branched-chained fatty acid, structurally unrelated to any other antiepileptic drug."6.39Valproic acid. A reappraisal of its pharmacological properties and clinical efficacy in epilepsy. ( Davis, R; McTavish, D; Peters, DH, 1994)
"Carnitine treatment does not always prevent the emergence of serious hepatotoxicity, but it does alleviate valproate-induced hyperammonemia."6.39Carnitine deficiency in epilepsy: Risk factors and treatment. ( Coulter, DL, 1995)
"Valproic acid has become a regular component of antiepileptic therapy."6.36[Valproic acid in the treatment of epilepsy with special emphasis on serum level determination (author's transl)]. ( Fröscher, W; Gugler, R; Schulz, HU, 1978)
" Other topics were: psychotropic effect of antiepileptic drugs, folic acid and vitamin D administration in epilepsy, and EEG investigations."6.15Controlled trials in epilepsy: a review. ( Bentsen, KD; Flachs, H; Gram, L; Parnas, J, 1982)
"Epilepsy is a chronic neurological disorder that is characterized by episodes of seizure."5.72Clinical Evaluation of Levetiracetam in the Treatment of Epilepsy. ( Guan, S; Liu, J; Qian, F; Wang, Y; Wu, H; Yang, J, 2022)
"Results: Mild cognitive impairment - MCI was diagnosed in 4 patients (28."5.72HYPERAMMONAEMIA AND COGNITIVE IMPAIRMENT IN EPILEPSY PATIENTS TREATED WITH VALPROIC ACID - PRELIMINARY STUDY. ( Dutkiewicz, J; Pilut, D; Szczygieł-Pilut, EE; Zajączkowska-Dutkiewicz, A, 2022)
"Valproic acid (VPA) is an antiepileptic drug, used for focal and generalized seizure."5.72The impact of valproic acid treatment on weight gain in pediatric patients with epilepsy. ( Battaglia, D; Blasi, V; DI Ruscio, F; Ferrara, P; Gatto, A, 2022)
"The study intended to analyze the effects of a group nursing intervention on quality of life (QoL) of patients with epilepsy (EP) after treatment with sodium valproate combined with lamotrigine."5.69Value of Group Intervention on Prognosis of Quality of Life in Epileptic Patients Treated With Sodium Valproate and Lamotrigine. ( Fan, X; Li, X; Li, Y; Wang, D; Wang, M; Xie, Z; Yin, J; Yu, J; Yu, M, 2023)
"Phospholipid-valproic acid (DP-VPA)is a prodrug for treating epilepsy."5.69Population pharmacokinetics and exposure-safety of lipophilic conjugates prodrug DP-VPA in healthy Chinese subjects for dose regime exploring. ( Cao, G; Chen, Y; Fan, Y; Guo, B; Hu, J; Li, X; Li, Y; Liu, X; Wang, Y; Wu, H; Wu, J; Wu, X; Xu, X; Yu, J; Yu, P; Zhan, H; Zhang, J, 2023)
"Epilepsy is one of the most frequent neurological disorders characterized by an enduring predisposition to generate epileptic seizures."5.62Histopathological and Biochemical Assessment of Neuroprotective Effects of Sodium Valproate and Lutein on the Pilocarpine Albino Rat Model of Epilepsy. ( Al-Rafiah, AR; Mehdar, KM, 2021)
"Carbamazepine was ineffective, and seizures were exacerbated with levetiracetam (LEV)."5.56Improvement of epilepsy with lacosamide in a patient with ring chromosome 20 syndrome. ( Goji, A; Kagami, S; Mori, T; Tayama, T; Toda, Y, 2020)
"Valproic acid (VPA) was a classic antiepileptic drug for fifty years."5.56Influence of age and co-medication on the concentration and efficacy of valproic acid in Chinese epilepsy children. ( Hu, W; Li, Z; Wang, Y, 2020)
" This study investigated the effect of delayed or missed doses on the pharmacokinetics (PK) of valproic acid (VPA) in patients with epilepsy and established remedial dosing recommendations for nonadherent patients."5.56Remedial dosing recommendations for delayed or missed doses of valproic acid in patients with epilepsy based on Monte Carlo simulations. ( Ding, JJ; Jiao, Z; Wang, CY; Yu, EQ; Zhu, GX, 2020)
"Epileptic seizures are frequent in patients with glioblastoma, and anticonvulsive treatment is often necessary."5.51AMPA receptor antagonist perampanel affects glioblastoma cell growth and glutamate release in vitro. ( Bergner, C; Hörnschemeyer, J; Kirschstein, T; Köhling, R; Krause, BJ; Lange, F; Linnebacher, M; Mullins, CS; Porath, K; Weßlau, K, 2019)
"Focal epilepsy was diagnosed in 244 (69."5.51Why do some women with epilepsy use valproic acid despite current guidelines? A single-center cohort study. ( Bosak, M; Słowik, A; Turaj, W, 2019)
"Curcumin is a phytochemical with promising effects on epilepsy treatment."5.48Micronization potentiates curcumin's anti-seizure effect and brings an important advance in epilepsy treatment. ( Aguiar, GPS; Bertoncello, KT; Oliveira, JV; Siebel, AM, 2018)
" Therefore, this study aimed to establish a population pharmacokinetic (PPK) model of LTG in Chinese children with epilepsy and to comprehensively evaluate the effects of genetic variations in drug-metabolizing enzymes, transporters, and a transcriptional regulator on LTG pharmacokinetics."5.48A Population Pharmacokinetic-Pharmacogenetic Model of Lamotrigine in Chinese Children With Epilepsy. ( Chen, Y; Lu, T; Wang, H; Wang, Z; Xu, S; Zhao, L; Zhao, M, 2018)
" While the concentration of 4-ene-VPA was not suitable as an early warning index, the results provide clear theoretical guidance for the rational and safe clinical use of VPA."5.46Association of CYP2C9, CYP2A6, ACSM2A, and CPT1A gene polymorphisms with adverse effects of valproic acid in Chinese patients with epilepsy. ( Ma, HY; Pan, J; Wang, C; Wang, P; Yang, LP; Yang, X, 2017)
"Valproic acid (VPA) is a widely prescribed broad-spectrum antiepileptic drug."5.46Influence of age and co-medication on the steady-state pharmacokinetics of valproic acid in Tunisian patients with epilepsy. ( Atheymen, R; Ben Mahmoud, L; Ghozzi, H; Hakim, A; Sahnoun, Z; Zeghal, K, 2017)
" The aim of the study was to conduct an in vivo evaluation of the relationship between treatments with synthetic cannabinoid arachidonyl-2'-chloroethylamide (ACEA) alone or in combination with valproic acid (VPA) and hippocampal neurogenesis in a mouse pilocarpine model of epilepsy."5.46A Long-Term Treatment with Arachidonyl-2'-Chloroethylamide Combined with Valproate Increases Neurogenesis in a Mouse Pilocarpine Model of Epilepsy. ( Andres-Mach, M; Dudra-Jastrzębska, M; Haratym, J; Haratym-Maj, A; Maj, M; Rola, R; Zagaja, M; Łuszczki, JJ, 2017)
"• Valproic acid has a cumulative effect on inhibiting brain activity in epileptogenic regions."5.46Resting-state fMRI revealed different brain activities responding to valproic acid and levetiracetam in benign epilepsy with central-temporal spikes. ( Dante, M; Hu, Z; Li, K; Li, Q; Li, Z; Lu, G; Wu, H; Xu, Q; Yang, F; Zhang, Q; Zhang, Z, 2017)
"Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy."5.43Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016)
" The correlation with dose may be a spurious finding related to the fact that physicians, in adjusting dosage according to clinical response, are more likely to use larger doses in patients with high clearance values."5.43An investigation of the influence of patient-related factors and comedications on lamotrigine clearance in patients with epilepsy. ( Alexandre, V; Baldoni, AO; de Santi Ferreira, FI; Freitas-Lima, P; Martinez, EZ; Pereira, LR; Perucca, E; Queiroz, RH; Sakamoto, AC, 2016)
"Valproic acid (VPA) follows a non-linear pharmacokinetic profile in terms of protein-binding saturation."5.42A population pharmacokinetic model of valproic acid in pediatric patients with epilepsy: a non-linear pharmacokinetic model based on protein-binding saturation. ( Ding, J; Jiao, Z; Li, X; Lin, W; Miao, L; Wang, C; Wang, Y; Zhao, L; Zhao, Z, 2015)
"Valproic acid treated animals were treated from 5 days preceding behavioral testing in the Morris water maze at a clinically relevant concentration."5.42Standard dose valproic acid does not cause additional cognitive impact in a rodent model of intractable epilepsy. ( Jellett, AP; Jenks, K; Lucas, M; Scott, RC, 2015)
" In this study, we developed a population-based pharmacokinetic (PK)-pharmacodynamic (PD) model to determine the optimal concentration of VPA according to the clinical characteristics of each patient."5.42Determination of the Optimal Concentration of Valproic Acid in Patients with Epilepsy: A Population Pharmacokinetic-Pharmacodynamic Analysis. ( Ishitsu, T; Matsuda, K; Nakagawa, K; Nakashima, H; Nishimura, M; Ogusu, N; Oniki, K; Ono, T; Saruwatari, J; Shimomasuda, M; Yasui-Furukori, N, 2015)
"Participants with focal epilepsy were randomised to receive lamotrigine, levetiracetam or zonisamide."5.41Lamotrigine versus levetiracetam or zonisamide for focal epilepsy and valproate versus levetiracetam for generalised and unclassified epilepsy: two SANAD II non-inferiority RCTs. ( Appleton, R; Baker, G; Balabanova, S; Brown, R; Burnside, G; Hindley, D; Howell, S; Hughes, DA; Leach, JP; Maguire, M; Marson, AG; Mohanraj, R; Plumpton, CO; Sills, G; Smith, D; Smith, PE; Taylor, C; Tudur-Smith, C; Williamson, PR, 2021)
"Valproic acid is prescribed for epilepsy and as prophylaxis for bipolar disorder and migraine headaches."5.41Kidney tubular injury induced by valproic acid: systematic literature review. ( Anguissola, G; Bianchetti, MG; Lava, SAG; Leu, D; Milani, GP; Scoglio, M; Simonetti, BG; Simonetti, GD, 2023)
"Hyperammonemia can occur after acute overdose or chronic use of valproic acid (VPA)."5.41Risk factors of hyperammonemia in epilepsy patients with valproic acid therapy. ( Kim, DW; Kwack, DW, 2023)
" In parallel, adenosine deficit is increasingly recognized in epilepsy pathophysiology."5.41Bipolar mania and epilepsy pathophysiology and treatment may converge in purine metabolism: A new perspective on available evidence. ( Boison, D; Daniels, SD, 2023)
"To establish using dried blood spot (DBS) as a surrogate to plasma for therapeutic drug monitoring (TDM) of carbamazepine (CBZ), we compared the population pharmacokinetic (PPK) estimates from concurrent DBS and plasma levels."5.40Estimation and comparison of carbamazepine population pharmacokinetics using dried blood spot and plasma concentrations from people with epilepsy: the clinical implication. ( Chan, E; Ho, PC; Kong, ST; Lim, SH, 2014)
"This retrospective study included 237 and 169 VPA-treated Japanese patients with epilepsy for population pharmacokinetic and pharmacokinetic-pharmacodynamic analyses, respectively."5.40Impact of the superoxide dismutase 2 Val16Ala polymorphism on the relationship between valproic acid exposure and elevation of γ-glutamyltransferase in patients with epilepsy: a population pharmacokinetic-pharmacodynamic analysis. ( Deguchi, M; Ishitsu, T; Kaneko, S; Nakagaswa, K; Nakashima, H; Nishimura, M; Noai, M; Ogusu, N; Oniki, K; Saruwatari, J; Yasui-Furukori, N, 2014)
"Epilepsy was induced by i."5.38Evaluation of the antiepileptic effect of curcumin and Nigella sativa oil in the pilocarpine model of epilepsy in comparison with valproate. ( Aboul Ezz, HS; Faraag, AR; Khadrawy, YA; Noor, NA, 2012)
"He had been on a lamotrigine treatment due to epilepsy, and after cessation of lamotrigine, his cardiac enzyme levels returned to normal."5.38Lamotrigine related myocarditis: case report. ( Bayhan, T; Karagöz, T; Sahin, M; Yıldırım, I, 2012)
"Curcumin was co-administered with sub-therapeutic dose of valproate 60min before PTZ injection."5.37Pharmacokinetic and pharmacodynamic interactions of valproate, phenytoin, phenobarbitone and carbamazepine with curcumin in experimental models of epilepsy in rats. ( Gupta, YK; Mehla, J; Pahuja, M; Reeta, KH, 2011)
"Valproic acid (VPA) is an anticonvulsant and mood-stabilizing drug for the long-term treatment."5.37Valproic Acid related metabolic syndrome in patients with epilepsy. ( Kasradze, S; Mania, M; Okujava, N, 2011)
" Plasma concentrations (pc), interactions between drugs in the ICU context, adverse effects and seizure occurrences were observed and recorded."5.37Levetiracetam compared to valproic acid: plasma concentration levels, adverse effects and interactions in aneurysmal subarachnoid hemorrhage. ( Bjeljac, M; Keller, E; Mink, S; Muroi, C; Seule, M, 2011)
"Treatment with curcumin, NSO or valproate ameliorated most of the changes induced by pilocarpine and restored Na⁺, K⁺-ATPase activity in the hippocampus to control levels."5.37The neuroprotective effect of curcumin and Nigella sativa oil against oxidative stress in the pilocarpine model of epilepsy: a comparison with valproate. ( Ezz, HS; Khadrawy, YA; Noor, NA, 2011)
"Valproic acid (VPA) is a widely used and well-tolerable antiepileptic drug in epileptic patients."5.35The effects of biotin supplementation on serum and liver tissue biotinidase enzyme activity and alopecia in rats which were administrated to valproic acid. ( Akin, R; Arslan, M; Balamtekin, N; Kurt, I; Ozcan, O; Unay, B; Vurucu, S, 2009)
"This trial evaluated the effect of cannabidiol on steady-state pharmacokinetics of stiripentol or valproate in patients with epilepsy, and the safety and tolerability of cannabidiol."5.34A Phase II Randomized Trial to Explore the Potential for Pharmacokinetic Drug-Drug Interactions with Stiripentol or Valproate when Combined with Cannabidiol in Patients with Epilepsy. ( Arenas Cabrera, CM; Ben-Menachem, E; Critchley, D; Crockett, J; Gunning, B; Morrison, G; Tayo, B; Toledo, M; VanLandingham, K; Wray, L, 2020)
"The aim of this study was to investigate the effects of sodium valproate (SV) and carbamazepine (CBZ) on neuromuscular transmission using single-fibre electromyography (SFEMG) in patients with epilepsy."5.34An investigation on the effects of carbamazepine and sodium valproate on neuromuscular transmission. ( Ay, H; Ethemoğlu, Ö, 2020)
"Epilepsy is one of the most common presentations of patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS)."5.34Valproic acid aggravates epilepsy due to MELAS in a patient with an A3243G mutation of mitochondrial DNA. ( Lin, CM; Thajeb, P, 2007)
"Lamotrigine was escalated according to a target dose of 200 mg/day over 8-weeks."5.34Conversion to lamotrigine monotherapy from valproate monotherapy in older adolescent patients with epilepsy. ( Baumann, RJ; Fakhoury, TA; Hammer, AE; Kustra, RP; Messenheimer, JA; Vuong, A, 2007)
"Valproic acid has been previously associated with hematologic toxicity, including a reversible myelodysplasia-like syndrome without chromosomal abnormalities."5.33Acute leukemia associated with valproic acid treatment: a novel mechanism for leukemogenesis? ( Bair, AK; Coyle, TE; Mehdi, S; Stein, C; Vajpayee, N; Wright, J, 2005)
" VPA was not found to have any clinically significant influence on TPM pharmacokinetic and metabolic profiles."5.33A comparative study of the effect of carbamazepine and valproic acid on the pharmacokinetics and metabolic profile of topiramate at steady state in patients with epilepsy. ( Bialer, M; Britzi, M; Doose, DR; Gatti, G; La Neve, A; Levy, RH; Maryanoff, BE; Mimrod, D; Perucca, E; Soback, S; Specchio, LM; Specchio, N, 2005)
"A 56-year-old woman with poorly controlled epilepsy, receiving valproate at subtherapeutic levels for 6 years, developed a life-threatening hyperammonemic coma following a moderate dosage increase."5.33Acute hyperammonemic coma with chronic valproic acid therapy. ( Abramson, RK; Cuturic, M, 2005)
"Valproic acid (VPA) is an antiepileptic drug (AED) used for generalized and absence seizures."5.32Effects of age and polytherapy, risk factors of valproic acid (VPA) hepatotoxicity, on the excretion of thiol conjugates of (E)-2,4-diene VPA in people with epilepsy taking VPA. ( Abbott, F; Farrell, K; Gopaul, S, 2003)
"Men with epilepsy are known to have reduced fertility."5.32Alterations in semen parameters in men with epilepsy treated with valproate or carbamazepine monotherapy. ( Bjørnenak, T; Gjerstad, L; Haugen, TB; Røste, LS; Saetre, ER; Taubøll, E, 2003)
"Pregnancy was otherwise uneventful."5.32Multiple congenital malformations including generalized hypertrichosis with gum hypertrophy in a child exposed to valproic acid in utero. ( Audeoud, F; Bernardin, A; Gaugler, C; Messer, J; Stoll, C, 2003)
" The severity of the cognitive side effects of TPM may be related to dosing to a certain extent, but this relationship may be disclosed only with larger sample sizes."5.32Cognitive profile of topiramate as compared with lamotrigine in epilepsy patients on antiepileptic drug polytherapy: relationships to blood serum levels and comedication. ( Elger, CE; Helmstaedter, C; Kockelmann, E, 2004)
" Everyone received a drug dosage which gave an adequate therapeutic plasma concentration and satisfactory seizure control."5.31[Bimodal evoked potentials during long-term therapy with conventional or slow release preparations of carbamazepine and valproic acid in children and adolescents with epilepsy]. ( Zgorzalewicz, M, 2000)
"Carbamazepine and depakine treatment during at least 6 months does not predispose to ovary polycystosis syndrome."5.31[The pharmacological and hormonal effects of carbamazepine and valproic acid in the treatment of reproductive age women with epilepsy]. ( Karlov, VA; Kushlinskiĭ, NE; Vlasov, PN, 2001)
"Valproic acid is an antiepileptic drug in widespread use."5.30Thrombocytopenic purpura and anemia in a breast-fed infant whose mother was treated with valproic acid. ( Neiderud, J; Stahl, MM; Vinge, E, 1997)
"To investigate the development of reproductive endocrine changes in Indian women with epilepsy initiating on either Valproate (VPA) or Lamotrigine (LTG) monotherapy."5.27Evaluate the effects of antiepileptic drugs on reproductive endocrine system in newly diagnosed female epileptic patients receiving either Valproate or Lamotrigine monotherapy: A prospective study. ( Sadhotra, A; Sidhu, HS; Srinivasa, R, 2018)
"Side effects of carbamazepine (CBZ), valproate (VPA) and clonazepam (CZP) are rare during long-term use but rather common and usually transient during the early phases of treatment."5.27Side effects of carbamazepine, valproate and clonazepam during long-term treatment of epilepsy. ( Keränen, T; Sivenius, J, 1983)
"Free and total valproic acid (VPA) pharmacokinetic evaluation was carried out at steady state in six young epileptics who were also receiving other anticonvulsants."5.27Free valproic acid: steady-state pharmacokinetics in patients with intractable epilepsy. ( Budnik, D; Hall, K; Irvine-Meek, J; Leroux, M; Otten, N; Seshia, S, 1984)
" Reducing the dosage by 19 mg/kg (A to B) decreased VPA plasma levels by 6."5.26Monitoring free valproic acid in epilepsy patients medicated with coanticonvulsants. ( Haidukewych, D; Rodin, EA, 1982)
" Valproic acid appears to be use cautionally in obese females with epilepsy."5.24Evaluate the effects of long-term valproic acid treatment on metabolic profiles in newly diagnosed or untreated female epileptic patients: A prospective study. ( Sadhotra, A; Sidhu, HS; Srinivas, R, 2017)
" This case describes a 38 year-old female with a past medical history of epilepsy effectively treated with meropenem to rapidly and safely lower toxic VPA levels after an acute ingestion."5.22Treatment of valproic acid overdose with meropenem in an epileptic patient. ( Clark, K; Cunningham, D; Lord, K, 2022)
"To estimate the safety and efficacy of sodium valproate combined with levetiracetam in paediatric patients with epilepsy based on randomized controlled trials (RCTs)."5.22Combined effects of levetiracetam and sodium valproate on paediatric patients with epilepsy: a systematic review and meta-analysis. ( Yang, J; Zhu, X; Zhu, Y, 2022)
"A literature search was performed in the PubMed, Embase, and OVID-Medline databases to identify articles related to epilepsy and lamotrigine that were published from the establishment of the database to April 2021."5.22The efficacy of lamotrigine after failure of the first administration of valproate in treating epilepsy: a systematic review and meta-analysis. ( He, J; Wu, X; Zhou, D, 2022)
"Valproic acid (VPA) is a widely used antiepileptic drug not recommended in pregnancy because it is teratogenic."5.22Transcriptome meta-analysis of valproic acid exposure in human embryonic stem cells. ( Gomes, JDA; Kowalski, TW; Lord, VO; Mariath, LM; Recamonde-Mendoza, M; Sgarioni, E; Vianna, FSL, 2022)
" Potential add-on AEDs in case of uncontrolled seizures include lacosamide, perampanel, and valproic acid."5.22Management of epilepsy in brain tumor patients. ( Koekkoek, JAF; Taphoorn, MJB; van der Meer, PB, 2022)
"This article will review the different therapeutic options for status, from early treatment at home to the different first-line (benzodiazepines), second-line (phenobarbital, valproic acid, phenytoin, levetiracetam and lacosamide) or third-line treatments, which include both pharmacological (anaesthetics, propofol, ketamine, lidocaine, topiramate, brivaracetam or perampanel) and non-pharmacological (ketogenic diet, immunomodulatory treatments or epilepsy surgery) therapies."5.22[Paediatric status epilepticus]. ( García-Peñas, JJ; González-Alguacil, E; Soto-Insuga, V, 2022)
" Participants had "failed" initial monotherapy for partial epilepsy and were randomized to substitution monotherapy with levetiracetam or an older AED (carbamazepine or valproate sodium)."5.22Monotherapy with Levetiracetam Versus Older AEDs: A Randomized Comparative Trial of Effects on Bone Health. ( Christie, J; Gorelik, A; Hakami, T; Kantor, S; O'Brien, TJ; Petty, SJ; Sakellarides, M; Seibel, MJ; Todaro, M; Wark, JD; Yerra, R, 2016)
" Three groups of patients were studied: (A) epileptic under phenytoin monotherapy (n = 31); (B) with bipolar disorder under valproic acid treatment (n = 28); (C) elderly (n = 41)."5.22Carnitine and/or Acetylcarnitine Deficiency as a Cause of Higher Levels of Ammonia. ( Fagiolino, P; González, R; Guevara, N; Maldonado, C; Queijo, C; Vázquez, M, 2016)
"This post-hoc subgroup analysis of data from an unblinded, randomized, 52-week superiority study (KOMET) compared the effectiveness of levetiracetam (LEV) with extended-release sodium valproate (VPA-ER) and controlled-release carbamazepine (CBZ-CR) as monotherapy in patients aged ≥ 60 years with newly diagnosed epilepsy."5.22Comparative effectiveness of levetiracetam, valproate and carbamazepine among elderly patients with newly diagnosed epilepsy: subgroup analysis of the randomized, unblinded KOMET study. ( Marson, AG; Noack-Rink, M; Pohlmann-Eden, B; Ramirez, F; Tofighy, A; Trinka, E; Werhahn, KJ; Wild, I, 2016)
"This Phase I, open-label, dose-escalation study investigated the effects of steady-state brivaracetam on the pharmacokinetics of carbamazepine in patients with epilepsy, with and without valproate co-administration."5.22Pharmacokinetic interaction of brivaracetam on carbamazepine in adult patients with epilepsy, with and without valproate co-administration. ( Brodie, MJ; Sargentini-Maier, ML; Stockis, A, 2016)
"Eighty-one patients participated in the study: 51 patients with chronic epilepsy (G1) treated with carbamazepine (CBZ) or valproic acid (VPA), and 30 patients with newly diagnosed epilepsy (G2)."5.16The effect of vitamin B supplementation on homocysteine metabolism and clinical state of patients with chronic epilepsy treated with carbamazepine and valproic acid. ( Bochyńska, A; Graban, A; Gugała-Iwaniuk, M; Lechowicz, W; Lipczyńska-Łojkowska, W; Lipska, B; Restel, M; Ryglewicz, D, 2012)
"The extent of lamotrigine interactions was investigated dependent on age, gender, weight and dose of concomitant carbamazepine and/or valproic acid in 65 patients with epilepsy."5.16Impact of age, weight and concomitant treatment on lamotrigine pharmacokinetics. ( Brzaković, BB; Martinović, ZJ; Miljković, BR; Pokrajac, MV; Prostran, MŠ; Vezmar Kovačević, SD; Vučićević, KM, 2012)
"This study aimed to evaluate the effects of monotherapy with valproate or oxcarbazepine on the linear growth of children with idiopathic epilepsy."5.16The effects of oxcarbazepine and valproate therapies on growth in children with epilepsy. ( Bideci, A; Camurdan, O; Cansu, A; Cinaz, P; Hirfanoglu, TL; Karaoglu, A; Serdaroglu, A; Yesilkaya, E, 2012)
"To explore the efficacy and safety of the combined therapy of valproic acid (VPA) and lamotrigine (LTG) for various types of epilepsy."5.16[Efficacy and safety of the combined therapy of valproic acid and lamotrigine for epileptics]. ( Hu, Q; Kang, HC; Li, X; Liu, XY; Liu, ZG; Wang, M; Xu, F; Zeng, Z; Zhu, SQ, 2012)
"Two broad spectrum AEDs, the traditional drug of sustained-release formulation of valproate (SRVPA) and the new-generation drug of topiramate, were compared in patients with epilepsy as monotherapy in this multi-centre, observational cohort study from 2000 to 2011."5.16Outcomes of sustained-release formulation of valproate and topiramate monotherapy in patients with epilepsy: a multi-centre, cohort study. ( Cao, Q; Chen, G; Ding, M; Hu, X; Hu, Y; Huang, X; Li, H; Liu, J; Lu, Y; Peng, B; Shen, D; Sun, H; Wang, X; Wu, M; Xi, Z; Zeng, K; Zhang, Y; Zhou, Y, 2012)
"The aim of this study is to investigate the effects of epilepsy, valproic acid and oxcarbazepine on nitric oxide levels, lipid peroxidation and xanthine oxidase levels in newly diagnosed epileptic children and healthy controls."5.15Effects of epilepsy and antiepileptic drugs on nitric oxide, lipid peroxidation and xanthine oxidase system in children with idiopathic epilepsy. ( Arhan, E; Kurt, N; Kutsal, E; Ozcelik, A; Ozturk, B; Ozturk, HS; Serdaroglu, A; Sevinc, N, 2011)
"To investigate the effect of topiramate on bone mass and metabolism in premenopausal women with epilepsy."5.15The effect of topiramate monotherapy on bone mineral density and markers of bone and mineral metabolism in premenopausal women with epilepsy. ( Heo, K; Kim, WJ; Lee, BI; Lee, HW; Lee, SA; Rhee, Y; Shin, DJ; Song, HK; Song, K, 2011)
"This open label study suggests that the combination of valproate, lamotrigine, and a benzodiazepine can markedly reduce the frequency of epileptic drop attacks in patients with generalized or multifocal epilepsies."5.15Long-term control of epileptic drop attacks with the combination of valproate, lamotrigine, and a benzodiazepine: a 'proof of concept,' open label study. ( Bastos, FA; Machado, VH; Palmini, A; Rotert, R, 2011)
"To explore efficacy and tolerability outcomes of topiramate (TPM) in patients with epilepsy transitioning from valproic acid (VPA) because of insufficient efficacy and/or tolerability onto TPM."5.14Conversion from valproic acid onto topiramate in adolescents and adults with epilepsy. ( Bogdanow, M; Lüer, W; Ossig, W; Schauble, B; Schreiner, A; Stollhoff, K; Unkelbach, S, 2009)
"The purpose of this study was to determine whether children with epilepsy undergoing valproate therapy and who are otherwise healthy have lower levels of serum and muscle carnitine."5.14Serum and muscle carnitine levels in epileptic children receiving sodium valproate. ( Anil, AB; Anil, M; Dilek, M; Helvaci, M; Kalenderer, O; Ozbal, E, 2009)
"Valproic acid (VPA) has been associated with hyperammonemia with and without encephalopathy."5.14Hyperammonemia following intravenous valproate loading. ( Beasley, MT; Cofield, S; DeWolfe, JL; Faught, E; Knowlton, RC; Limdi, NA, 2009)
" We evaluated the reproductive endocrine and insulin-related metabolic parameters in men and women with untreated epilepsy randomized to valproate (n=44) or lamotrigine (n=37) monotherapy for 12 months."5.14Effects of valproate or lamotrigine monotherapy on the reproductive endocrine and insulin-related metabolic profile in Chinese adults with epilepsy: a prospective randomized study. ( Chan, IH; Chan, MH; Hui, AC; Hui, KF; Kwan, P; Lam, CW; Leung, H; Ng, PW; Yip, FP, 2009)
"Valproate (VPA) administration may be associated with adverse metabolic effects, among is hyperammonemia, which could suggest metabolic abnormalities as carnitine deficiency."5.14The risk of asymptomatic hyperammonemia in children with idiopathic epilepsy treated with valproate: relationship to blood carnitine status. ( Abdella, MM; Hamed, SA, 2009)
"For a retrospective observational investigation based on real clinical practice of relative efficacy of valpoic acid (VPA), carbamazepine (CBZ) and topiramate (TPM) we have selected 106 patients with age of seizure onset before 17 years with a undoubted diagnosis of symptomatic or cryptogenic occipital lobe epilepsy (OLE), who had received treatment according to ILAE recommendations, and observation time since the last treatment change was from 2 to 10 years."5.14[Comparative efficacy of carbamazepine, valproic acid and topiramate in symptomatic and cryptogenic occipital lobe epilepsy in children]. ( , 2010)
"To evaluate development of components of polycystic ovary syndrome (PCOS) and PCOS in women with epilepsy initiating valproate or lamotrigine therapy."5.13Hyperandrogenism, ovulatory dysfunction, and polycystic ovary syndrome with valproate versus lamotrigine. ( Adams, JM; Bhatt, M; Hayes, FJ; Isojärvi, J; Morrell, MJ; Ozkara, C; Sluss, PM; Warnock, CR, 2008)
"To evaluate the efficacy and tolerability of the treatment with valproic acid (VPA) in patients with status epilepticus (SE) or acute repetitive seizures (ARS) comparing it with phenytoin (PHT) treatment."5.13Treatment of status epilepticus and acute repetitive seizures with i.v. valproic acid vs phenytoin. ( Dabby, R; Gilad, R; Izkovitz, N; Lampl, Y; Rapoport, A; Sadeh, M; Weller, B, 2008)
"The present study was designed to reveal changes of cognitive processes in epilepsy (EP) patients with Topiramate (TPM) or Valproate (VPA) treatment using Wechsler Adult Intelligence Scale (WAIS-CR) and event-related potential (ERP)."5.13Attention changes in epilepsy patients following 3-month topiramate or valproate treatment revealed by event-related potential. ( Sun, W; Wang, W; Wang, Y; Wu, X, 2008)
"Valproic acid (VPA) is a well-established anticonvulsant drug discovered serendipitously and marketed for the treatment of epilepsy, migraine, bipolar disorder and neuropathic pain."5.12Insights into Structural Modifications of Valproic Acid and Their Pharmacological Profile. ( Bora, S; Hasija, Y; Kukal, S; Kukreti, R; Kukreti, S; Mishra, MK; Muthusamy, K; Paul, PR; Saso, L; Singh, A, 2021)
" This paper aims to undertake a comprehensive review regarding the possible risks of four classical (phenytoin, carbamazepine, phenobarbital, and valproate) and two newer (lamotrigine and levetiracetam) AEDs during pregnancy."5.12Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications. ( Demir, O; Kaplan, YC, 2021)
"This study was performed to evaluate carnitine deficiency in a large series of epilepsy children and adolescents treated with old and new antiepileptic drugs with or without ketogenic diet."5.12Plasma free carnitine in epilepsy children, adolescents and young adults treated with old and new antiepileptic drugs with or without ketogenic diet. ( Auricchio, G; Coppola, G; Epifanio, G; Federico, RR; Pascotto, A; Resicato, G, 2006)
"We conducted a study to assess the effect of phenobarbital, carbamazepine, and valproate on serum lipid profiles and lipoprotein (a) in 64 children with epilepsy (aged between 1 and 15 years) admitted to the child neurology outpatient clinic between July 2000 and July 2002."5.12Effect of antiepileptic drugs on plasma lipids, lipoprotein (a), and liver enzymes. ( Aslan, A; Demir, E; Orem, A; Orhan, F; Sonmez, FM; Topbas, M; Yildirmis, S, 2006)
"Quantitative EEG (QEEG) effects of therapeutic doses of carbamazepine (CBZ), oxcarbazepine (OXC), valproate (VA) and lamotrigine (LA) monotherapy were investigated in patients with beginning epilepsy."5.12Quantitative EEG effects of carbamazepine, oxcarbazepine, valproate, lamotrigine, and possible clinical relevance of the findings. ( Altmann, A; Bessenyei, M; Clemens, B; Hollódy, K; Jerney, J; Kollár, K; Ménes, A; Piros, P; Rosdy, B; Rózsavölgyi, M; Steinecker, K, 2006)
"In eight women treated with lamotrigine monotherapy, the lamotrigine dose/plasma concentration (D/C) ratio increased by 295% from baseline outside pregnancy to midgestation, whereas in six women treated with lamotrigine in combination with valproate, the increase was only 60%."5.12Valproate effects on kinetics of lamotrigine in pregnancy and treatment with oral contraceptives. ( Luef, G; Ohman, I; Pittschieler, S; Sabers, A; Tomson, T, 2006)
"We have performed a randomised, prospective study to compare the efficacy and tolerability of sodium valproate (VPA) and lamotrigine (LTG) monotherapy, and their effects on circulating androgenic hormones, in newly diagnosed epilepsy."5.12Sodium valproate versus lamotrigine: a randomised comparison of efficacy, tolerability and effects on circulating androgenic hormones in newly diagnosed epilepsy. ( Brodie, MJ; Butler, E; Hitiris, N; Leach, JP; Leach, VM; Parker, P; Sills, GJ; Stephen, LJ; Wilson, EA, 2007)
"To determine whether levetiracetam (LEV) affects plasma concentrations of carbamazepine, valproic acid, topiramate, and lamotrigine in children with epilepsy."5.12Lack of pharmacokinetic interaction of levetiracetam on carbamazepine, valproic acid, topiramate, and lamotrigine in children with epilepsy. ( De Smedt, H; Otoul, C; Stockis, A, 2007)
"To compare clinicians' choice of one of the standard epilepsy drug treatments (carbamazepine or valproate) versus appropriate comparator new drugs."5.12A randomised controlled trial examining the longer-term outcomes of standard versus new antiepileptic drugs. The SANAD trial. ( Appleton, R; Baker, GA; Chadwick, DW; Doughty, J; Eaton, B; Gamble, C; Jacoby, A; Marson, AG; Shackley, P; Smith, DF; Tudur-Smith, C; Vanoli, A; Williamson, PR, 2007)
" Weight gain is a significant side effect of valproic acid, which has not been clearly identified pathogenetically."5.12The role of ghrelin in weight gain and growth in epileptic children using valproate. ( Akinci, A; Gungor, S; Ozerol, IH; Tabel, Y; Yologlu, S; Yücel, G, 2007)
" The aim of this study was to evaluate thyroid function in 78 girls taking carbamazepine (CBZ), oxcarbazepine (OXC), or valproate (VPA) monotherapy for epilepsy and after withdrawal of the treatment."5.11Thyroid function in girls with epilepsy with carbamazepine, oxcarbazepine, or valproate monotherapy and after withdrawal of medication. ( Isojärvi, JI; Knip, M; Mikkonen, K; Myllylä, VV; Pakarinen, AJ; Rättyä, J; Vainionpää, LK, 2004)
"In a novel double-blind trial, topiramate was compared with the investigator's choice of carbamazepine or valproate as first-line therapy in patients as young as 6 years of age with newly diagnosed epilepsy."5.11Topiramate, carbamazepine, and valproate monotherapy: double-blind comparison in children with newly diagnosed epilepsy. ( Neto, W; Wang, S; Wheless, JW, 2004)
"This randomized, open-label study was designed to compare the efficacy and tolerability of lamotrigine monotherapy with those of valproate and carbamazepine monotherapy in patients with epilepsy whose seizures were uncontrolled on their prestudy antiepileptic drug monotherapy."5.11Efficacy and tolerability of conversion to monotherapy with lamotrigine compared with valproate and carbamazepine in patients with epilepsy. ( Fakhoury, TA; Hammer, AE; Messenheimer, JA; Vuong, A, 2004)
"A dosing algorithm was used to guide the conversion of 77 patients with epilepsy (16 years of age) from valproate monotherapy through lamotrigine adjunctive therapy at 200mg daily to lamotrigine monotherapy at 500 mg daily in an open-label study comprising a lamotrigine escalation phase (8 weeks), a valproate withdrawal phase (6 weeks), and a lamotrigine monotherapy phase (4 weeks)."5.11A dosing algorithm for converting from valproate monotherapy to lamotrigine monotherapy in patients with epilepsy. ( Biton, V; Blum, D; Hammer, AE; Messenheimer, JA; Natarajan, S; Sale, ME; Vuong, A, 2005)
"To determine whether valproic acid [divalproex (DVP)] extended-release, administered at a higher proportionate once-daily dosage, can be safely substituted for delayed-release or sprinkle in pediatric patients with epilepsy."5.11Extended-release divalproex in child and adolescent outpatients with epilepsy. ( Jiang, P; Kernitsky, L; O'Hara, KA; Pellock, JM, 2005)
"Evaluation of the effectiveness of lamotrigine in a population-based cohort of epilepsy patients."5.11Effectiveness of lamotrigine in clinical practice: results of a retrospective population-based study. ( Deckers, CL; Egberts, AC; Hekster, YA; Keyser, A; Knoester, PD; Renier, WO, 2005)
"A significant weight gain and increase in serum leptin levels in the course of antiepileptic treatment with valproic acid (VPA) has been described in several clinical studies."5.10Increase in postprandial serum insulin levels in epileptic patients with valproic acid therapy. ( Abraham, I; Bauer, G; Hoppichler, F; Lechleitner, M; Luef, G; Trinka, E; Unterberger, I, 2002)
"Body mass index (BMI) and fasting serum concentrations of insulin and lipids were measured in 102 men with epilepsy who were treated with VPA, carbamazepine (CBZ), or oxcarbazepine (OXC) monotherapy."5.10Fasting serum insulin and lipid levels in men with epilepsy. ( Isojärvi, JI; Knip, M; Kotila, M; Myllylä, VV; Pakarinen, AJ; Pylvänen, V; Rättyä, J; Turkka, J, 2003)
"To compare topiramate (TPM) with investigator's choice of carbamazepine (CBZ) or valproate (VPA) for initial treatment in patients with newly diagnosed epilepsy."5.10Topiramate, carbamazepine and valproate monotherapy: double-blind comparison in newly diagnosed epilepsy. ( Brodie, MJ; Chadwick, DW; Mattson, RH; Neto, W; Privitera, MD; Wang, S, 2003)
"The authors assessed the effect of concomitant antiepileptic therapy on steady-state plasma concentrations of the new antiepileptic drug (AED) topiramate and the potential relation between topiramate plasma levels and side effects in a cohort of 116 patients with epilepsy."5.10Topiramate therapeutic monitoring in patients with epilepsy: effect of concomitant antiepileptic drugs. ( Albani, F; Avoni, P; Baruzzi, A; Contin, M; Riva, R, 2002)
"We studied the efficacy of felbamate (FBM) in combination with valproic acid (VPA) in 13 patients with the Lennox-Gastaut syndrome and evaluated the contribution of each drug."5.09The efficacy of felbamate as add-on therapy to valproic acid in the Lennox-Gastaut syndrome. ( Flamini, R; Gaillard, WD; Kelley, K; Ko, D; Malow, B; Reeves-Tyer, P; Siegel, H; Stertz, B; Theodore, WH, 1999)
"One-hundred eighty patients with partial or idiopathic generalized nonabsence epilepsy, aged 6 to 65 years, requiring initiation of treatment with carbamazepine (CBZ), valproate (VPA), phenytoin (PHT), phenobarbital (PB), or primidone (PRM) were randomly allocated to two groups according to an open, prospective parallel-group design."5.09A multicenter randomized controlled trial on the clinical impact of therapeutic drug monitoring in patients with newly diagnosed epilepsy. The Italian TDM Study Group in Epilepsy. ( Bartoli, A; Cian, P; Fattore, C; Gatti, G; Jannuzzi, G; Monaco, F; Perucca, E, 2000)
"5-18 yrs with intractable epilepsy and comedicated with carbamazepine or valproate."5.09Plasma and urinary serotonin and 5-HIAA in children treated with lamotrigine for intractable epilepsy. ( Jović, NJ; Majkić-Singh, N; Milovanović, DD; Mirković, D, 1999)
"to describe the population pharmacokinetics of lamotrigine (LTG) in developmentally disabled (DD) patients with epilepsy and (2) to determine if there is an effect of valproate (VPA) concentration on the extent of the pharmacokinetic interaction between VPA and LTG."5.09Lack of an effect of valproate concentration on lamotrigine pharmacokinetics in developmentally disabled patients with epilepsy. ( Anderson, GD; Gidal, BE; Lanning, A; Rutecki, PR; Shaw, R, 2000)
" The primary aim of the study was to evaluate lamotrigine add-on therapy and consecutive monotherapy in patients with epilepsy whose seizures were not controlled by carbamazepine or valproate."5.09Open study evaluating lamotrigine efficacy and safety in add-on treatment and consecutive monotherapy in patients with carbamazepine- or valproate-resistant epilepsy. ( Jozwiak, S; Terczynski, A, 2000)
"Lamotrigine (LTG) is one of the newer antiepileptic drugs which has been shown to have a spectrum of drug interactions (including with other epilepsy drugs) that can have a pronounced effect on LTG kinetics."5.09Clinical study of lamotrigine and valproic acid in patients with epilepsy: using a drug interaction to advantage? ( Black, AB; Lam, E; Morris, RG; Westley, IS, 2000)
"To compare the incidence and magnitude of change in body weight associated with lamotrigine or divalproex sodium monotherapy in patients with epilepsy."5.09Weight change associated with valproate and lamotrigine monotherapy in patients with epilepsy. ( Barrett, PS; Biton, V; Hammer, AE; Mirza, W; Montouris, G; Vuong, A, 2001)
"To investigate the effects of valproic acid (VPA) on renal tubular function, we examined 15 ambulatory children with epilepsy who received VPA for at least 6 months."5.09Renal tubular dysfunction in epileptic children on valproic acid therapy. ( Altunbaşak, S; Anarat, A; Burgut, HR; Yildizaş, D, 2001)
"We retrospectively evaluated the ability of Scatchard binding equation method to predict the unbound serum valproic acid (VPA) concentration in 37 pediatric patients with epilepsy receiving VPA monotherapy."5.08Evaluation of binding equation method for prediction of unbound serum valproic acid concentration in pediatric patients with epilepsy. ( Fujii, I; Kodama, H; Kodama, Y; Koike, Y; Kuranari, M; Takeyama, M; Yasunaga, F, 1995)
"We determined serum levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), and triglycerides (TGs) in 125 healthy children and in 119 children with epilepsy who had been receiving carbamazepine (58 children), phenobarbital (22 children), or valproic acid (39 children) for 7 months to 10."5.08Effects of long-term treatment with antiepileptic drugs on serum lipid levels in children with epilepsy. ( Bravo, M; Castro-Gago, M; Del Río, MC; Eirís, JM; Lojo, S; Novo, I; Pavón, P, 1995)
"Using a randomized parallel group study design, we compared the cognit ive effects of carbamazepine (CBZ), phenobarbital (PB), and valproate (VPA) in children with epilepsy."5.08Comparison of antiepileptic drugs on cognitive function in newly diagnosed epileptic children: a psychometric and neurophysiological study. ( Chen, YJ; Kang, WM; So, WC, 1996)
"This report describes the first experiences with monitoring of valproic acid pharmacokinetics in patients with epilepsy by subcutaneous microdialysis."5.08Monitoring free extracellular valproic acid by microdialysis in epileptic patients. ( Alm, C; Ekquist, B; Lundquist, B; Ståhle, L; Tomson, T, 1996)
"To assess the effects of carbamazepine vs valproate sodium on cognitive functioning in patients with epilepsy compared with normal control subjects."5.08Effect of valproate on cognitive functioning. Comparison with carbamazepine. The Department of Veterans Affairs Epilepsy Cooperative Study 264 Group. ( Cattanach, L; Collins, JF; Cramer, JA; Delaney, RC; Mattson, RH; Prevey, ML, 1996)
"Three hundred and forty seven patients with epilepsy from 54 centres across Europe not fully controlled with sodium valproate (VPA, n = 117), carbamazepine (CBZ, n = 129), phenytoin (PHT, n = 92) or phenobarbital (PB, n = 9) monotherapy were recruited into a lamotrigine (LTG) substitution study."5.08Lamotrigine substitution study: evidence for synergism with sodium valproate? 105 Study Group. ( Brodie, MJ; Yuen, AW, 1997)
" This paper presents an analysis of body weight data gathered during a randomized trial comparing valproate with carbamazepine in 260 children aged 4-15 years with newly-diagnosed epilepsy."5.08Weight gain with valproate or carbamazepine--a reappraisal. ( Easter, D; O'Bryan-Tear, CG; Verity, C, 1997)
"We have analyzed the records retrospectively and interviewed 70 adult patients attending an epilepsy clinic on VPA mono- or polytherapy followed over a median of 27 months (range 3-189), as well as 20 patients on carbamazepine (CBZ) monotherapy."5.08Weight gain in epileptic patients during treatment with valproic acid: a retrospective study. ( Corman, CL; Guberman, AH; Leung, NM, 1997)
"We report the results of an open trial with lamotrigine (LTG) as add-on drug in children and adolescents with refractory epilepsy and mental delay."5.08Lamotrigine as add-on drug in children and adolescents with refractory epilepsy and mental delay: an open trial. ( Coppola, G; Pascotto, A, 1997)
"To evaluate population pharmacokinetics and the relationship between plasma concentration and daily dose of valproic acid (VPA) in a homogeneous group of children with epilepsy."5.08Valproic acid clearance in children with epilepsy. ( López, E; Quintana, MB; Rodríguez, I; Sánchez-Alcaraz, A, 1998)
"The drug encorat, an analogue of valproic acid (Sun, India) was given to 16 children aged from 4 month to 5 years suffering from resistant forms of early infantile epilepsy."5.07[The enkorat treatment of infantile spasms and the Lennox-Gastaut syndrome]. ( Badalian, LO; Iskander, MB; Kharlamov, DA; Medvedev, MI; Mukhin, KIu; Temin, PA; Veselov, NK, 1994)
"Subjects with epilepsy (three men and seven women; age range, 20 to 39 years; weight range, 53 to 88 kg) who were previously stabilized with valproic acid, 9."5.07The effect of felbamate on valproic acid disposition. ( Graves, NM; Leppik, IE; Perhach, JL; Remmel, RP; Shumaker, RC; Wagner, ML; Ward, DL, 1994)
"Sixty-four new cases of childhood epilepsy were randomly assigned to either carbamazepine, phenytoin or sodium valproate, and were assessed with behavioural measures before medication and after one and six months of treatment."5.07Psychiatric aspects of epilepsy in childhood treated with carbamazepine, phenytoin or sodium valproate: a random trial. ( Berg, I; Butler, A; Ellis, M; Foster, J, 1993)
"Thirteen children with intractable epilepsy were treated by means of three-times-daily administration of a conventional preparation of valproic acid (C-VPA) and twice-daily administration of a new slow-release preparation of VPA (SR-VPA) with the cross-over technique."5.07A comparative clinical and pharmacokinetic study of a new slow-release versus conventional preparations of valproic acid in children with intractable epilepsy. ( Fukuyama, Y; Imaizumi, T; Izumi, T, 1992)
"The effects of adding vigabatrin (GVG) to the antiepileptic regimens of 16 children with refractory epilepsy have been studied."5.07Coadministration of vigabatrin and valproate in children with refractory epilepsy. ( Armijo, JA; Arteaga, R; Herranz, JL; Valdizán, EM, 1992)
"Sixty-four new cases of childhood epilepsy were randomly assigned to either carbamazepine, phenytoin or sodium valproate, and were assessed with cognitive tests before medication and three subsequent times over a year."5.07Cognitive impairment in new cases of epilepsy randomly assigned to carbamazepine, phenytoin and sodium valproate. ( Berg, I; Butler, R; Forsythe, I; McGuire, R, 1991)
"Taltrimide was compared with valproate and placebo in 17 patients with intractable epilepsy being on carbamazepine monotherapy."5.06A controlled study with taltrimide and sodium valproate: valproate effective in partial epilepsy. ( Allonen, H; Iivanainen, M; Neuvonen, PJ; Parantainen, J; Tamminen, M; Tokola, O; Waltimo, O, 1990)
" All the patients had epilepsy that had previously been untreated, and had been randomly assigned to receive carbamazepine, phenytoin, or sodium valproate."5.06Withdrawal of anticonvulsant drugs in patients free of seizures for two years. A prospective study. ( Callaghan, N; Garrett, A; Goggin, T, 1988)
"A prospective, double-blind, placebo-controlled investigation of possible withdrawal symptoms from phenytoin, carbamazepine and sodium valproate is reported in patients with active epilepsy, on combination therapy."5.06Withdrawal symptoms from phenytoin, carbamazepine and sodium valproate. ( Duncan, JS; Shorvon, SD; Trimble, MR, 1988)
"Long-term use of valproic acid in treating children with epilepsy can lead to a reduction in 25-OH-VitD and BMD."5.05Effects of valproic acid on skeletal metabolism in children with epilepsy: a systematic evaluation and meta-analysis based on 14 studies. ( Biaoxue, R; Chunyan, W; Min, L, 2020)
"The discovery of the anticonvulsant properties of valproic acid and the development of valproic acid/valproate to market authorization for specific epilepsy types and syndromes, as well as their repurposing for other indications, are illustrative examples of both the strengths and weaknesses of drug development strategies."5.05Lessons learned from the discovery of sodium valproate and what has this meant to future drug discovery efforts? ( Janković, SM; Janković, SV, 2020)
" The study included a total of 183 pediatric epilepsy patients, aged 15 months-16 years, comprising 114 patients treated with valproic acid, 69 patients treated with phenobarbital, and 151 age-matched healthy volunteers as the control group."5.05The effect of antiepileptic drugs on thyroid hormonal function: valproic acid and phenobarbital. ( Güngör, O; Özkaya, AK; Temiz, F, 2020)
"Eighty-eight patients with the onset of epilepsy in adult life were randomly allocated to treatment with sodium valproate (600 mg/day), or phenytoin (300 mg/day), and followed up for at least 12 months."5.05A comparison of phenytoin and valproate in previously untreated adult epileptic patients. ( Chadwick, DW; Rawlins, MD; Turnbull, DM; Weightman, D, 1982)
"We evaluated valproic acid (VPA) for 6 months as therapy for uncontrolled seizures in 100 children, 38 with partial and 62 with generalized epilepsy."5.05Treatment of childhood epilepsy with valproic acid: results of the first 100 patients in a 6-month trial. ( Couri, D; Sherard, ES; Steiman, GS, 1980)
"Valproic acid, a new anticonvulsant, is most effective in absence seizures (simple and complex), but it has produced improvement in tonicclonic seizures, mixed absence with tonic-clonic seizures, and myoclonic epilepsy."5.04Valproic acid (Depakene). A new anticonvulsant agent. ( Lewis, JR, 1978)
"We conducted this meta-analysis to evaluate effects of second-generation anti-epileptic drugs (AEDs; levetiracetam, lamotrigine) compared to first-generation AEDs (valproic acid, carbamazepine) on bone metabolism in epilepsy patients."5.01Effects of Second-Generation Antiepileptic Drugs Compared to First-Generation Antiepileptic Drugs on Bone Metabolism in Patients with Epilepsy: A Meta-Analysis. ( Chen, Y; Fu, J; Li, J; Peng, L; Tao, T, 2019)
"Valproic acid (VPA) as a widely used primary medication in the treatment of epilepsy is associated with reversible or irreversible hepatotoxicity."5.01Valproic Acid and the Liver Injury in Patients with Epilepsy: An Update. ( Chen, F; Guo, HL; Hu, YH; Jing, X; Lu, XP; Ni, MM; Qiu, JC; Sun, JY; Wang, T; Xu, ZJ, 2019)
"We systematically reviewed studies to provide current evidence about the incidence and risk of alopecia in patients undergoing valproic acid (VPA) therapy."5.01Risk of valproic acid-related alopecia: A systematic review and meta-analysis. ( Liu, L; Wang, H; Wang, X; Xu, D; Zhu, L, 2019)
"Valproic acid (VPA) is frequently used in the treatment of epilepsy."5.01CPS1 T1405N polymorphism, HDL cholesterol, homocysteine and renal function are risk factors of VPA induced hyperammonemia among epilepsy patients. ( Chen, D; Chen, L; Chen, P; Gao, X; Li, C; Li, H; Li, Y; Tian, Q; Tian, X; Wen, J; Yang, H; Zhang, M, 2019)
" The point estimates of carbamazepine and lamotrigine efficacy showed their superiority with respect to all comparator antiepileptic drugs for the treatment of newly diagnosed focal epilepsy."4.98Comparative efficacy of antiepileptic drugs in children and adolescents: A network meta-analysis. ( Crescioli, G; De Masi, S; Guerrini, R; Ilvento, L; Lucenteforte, E; McGreevy, KS; Mugelli, A; Pugi, A; Rosati, A; Virgili, G, 2018)
"Lamotrigine is used in pregnancy to control epilepsy and mood disorders."4.95Pregnancy Outcomes Following In Utero Exposure to Lamotrigine: A Systematic Review and Meta-Analysis. ( Adams-Webber, T; Barzilay, E; Leibson, T; Nulman, I; Pariente, G; Shulman, T, 2017)
" Oxcarbazepine and lamotrigine were associated with increased occurrence of autism."4.95Comparative safety of antiepileptic drugs for neurological development in children exposed during pregnancy and breast feeding: a systematic review and network meta-analysis. ( Cogo, E; D'Souza, J; Finkelstein, Y; Hemmelgarn, BR; Hutton, B; Kealey, R; MacDonald, H; Reynen, E; Rios, P; Soobiah, C; Straus, SE; Thavorn, K; Tricco, AC; Veroniki, AA; Yazdi, F, 2017)
"Valproic acid is an anticonvulsant and mood-stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder."4.95The pharmacogenomics of valproic acid. ( Chen, XP; Li, HL; Luo, J; Shi, LH; Zhang, ZL; Zhu, MM, 2017)
" Antiepileptic drugs (AED) such as phenytoin are often used in clinical practice with the hopes of preventing post-traumatic epilepsy."4.91Pharmacological treatments for preventing epilepsy following traumatic head injury. ( Abel, H; Campbell, LA; Pohlmann-Eden, B; Thompson, K, 2015)
"To determine whether valproate (VPA) monotherapy influences homocysteine metabolism in patients with epilepsy."4.90Increased homocysteine levels in valproate-treated patients with epilepsy: a meta-analysis. ( Chen, Y; Chen, Z; Fang, Z; Ni, G; Qin, J; Zhou, J; Zhou, L, 2014)
"Valproic acid is an effective first line drug for the treatment of epilepsy."4.90Valproic acid and fatalities in children: a review of individual case safety reports in VigiBase. ( Choonara, I; Edwards, IR; Star, K, 2014)
"The developmental quotient (DQ) was lower in children exposed to carbamazepine (CBZ) (n = 50) than in children born to women without epilepsy (n = 79); mean difference (MD) of -5."4.90Treatment for epilepsy in pregnancy: neurodevelopmental outcomes in the child. ( Adab, N; Bromley, R; Greenhalgh, J; Marson, AG; McKay, AJ; Sanniti, A; Tudur Smith, C; Weston, J, 2014)
"Valproic acid is a widely-used first-generation antiepileptic drug, prescribed predominantly in epilepsy and psychiatric disorders."4.89Adverse drug reactions induced by valproic acid. ( Nanau, RM; Neuman, MG, 2013)
" VPA-induced weight gain seems to be associated with many metabolic disturbances; the most frequent are hyperinsulinemia and insulin resistance, hyperleptinemia and leptin resistance."4.89Metabolic and endocrine effects of valproic acid chronic treatment. ( Belcastro, V; D'Egidio, C; Striano, P; Verrotti, A, 2013)
"In this systematic review we present information relating to the effectiveness and safety of the following interventions: monotherapy using carbamazepine, gabapentin, lamotrigine, levetiracetam, phenobarbital, phenytoin, sodium valproate, or topiramate; addition of second-line drugs (lamotrigine or levetiracetam) for drug-resistant epilepsy; and hemispherectomy for drug-resistant epilepsy."4.88Epilepsy (generalised). ( Maguire, M; Marson, AG; Ramaratnam, S, 2012)
"In the last years, a growing body of literature indicates an association between valproic acid therapy and weight gain."4.87Weight gain following treatment with valproic acid: pathogenetic mechanisms and clinical implications. ( Chiarelli, F; Coppola, G; D'Egidio, C; Mohn, A; Verrotti, A, 2011)
"In this systematic review we present information relating to the effectiveness and safety of the following interventions: monotherapy using carbamazepine, gabapentin, lamotrigine, levetiracetam, phenobarbital, phenytoin, sodium valproate, or topiramate; addition of second-line drugs (lamotrigine or levetiracetam) for drug-resistant epilepsy; and hemispherectomy for drug-resistant epilepsy."4.86Epilepsy (generalised). ( Maguire, M; Marson, AG; Ramaratnam, S, 2010)
"Valproic acid (VPA), a widely used antiepileptic drug, has broad-spectrum activity against both generalized and partial epilepsy."4.85Valproate-induced insulin resistance and obesity in children. ( Chiarelli, F; la Torre, R; Mohn, A; Trotta, D; Verrotti, A, 2009)
" The present study aims to determine the distribution pattern of UGT1A6 and UGT2B7 gene polymorphism and its possible impact on the metabolism of valproic acid (VPA) and carbamazepine (CBZ) in patients with epilepsy from Khyber Pakhtunkhwa region of Pakistan."4.84Distribution pattern of UGT1A6 and UGT2B7 gene polymorphism and its impact on the pharmacokinetics of valproic acid and carbamazepine: Prospective genetic association study conducted in Pakistani patients with epilepsy. ( Ali, N; Almarshad, F; Alshahrani, AM; Jamil, A; Saleh Faisal, M, 2024)
"This review analyses the concept of extended-release (ER) formulations in epilepsy and evaluates ER formulations of carbamazepine, valproic acid and a modified-release (MR) formulation of oxcarbazepine."4.84Extended-release formulations for the treatment of epilepsy. ( Bialer, M, 2007)
"Valproic acid (2-n-propylpentanoic acid, VPA) is well-established as a mood-stabilizer for bipolar disorder, in addition to its application as a treatment in neurological disorders such as epilepsy, migraine headaches, and chronic neuropathic pain."4.84Valproate and neuroendocrine changes in relation to women treated for epilepsy and bipolar disorder: a review. ( Rasgon, NL; Reynolds, MF; Sisk, EC, 2007)
"At present there are three compounds in clinical trials in patients with epilepsy that can be regarded as second-generation VPA: valproyl glycinamide, 3-methylbutanamide or isovaleramide and SPD421 (DP-VPA)."4.82New CNS-active drugs which are second-generation valproic acid: can they lead to the development of a magic bullet? ( Bialer, M; Isoherranen, N; Yagen, B, 2003)
"The author reports one case of pseudocyst of the pancreas, an uncommon disorder in children, secondary to pancreatitis in a 9-year-old girl treated with valproic acid for epilepsy."4.82Pancreatic pseudocyst caused by valproic acid: case report and review of the literature. ( Hernández, F; Queizán, A; Rivas, S, 2003)
"Valproic acid (VPA) is a commonly prescribed medication approved for use in the United States for epilepsy, migraine, and bipolar disorder."4.82Acute pancreatitis in children from Valproic acid: case series and review. ( Feldman-Winter, LB; Goldfarb, O; Grauso-Eby, NL; McAbee, GN, 2003)
" However, a particular association of valproate and carbamazepine with neural tube defects (NTDs)--specifically, with spina bifida aperta (SB)--has been identified."4.82Management issues for women with epilepsy: neural tube defects and folic acid supplementation. ( Yerby, MS, 2003)
"Valproic acid, a branched chain carboxylic acid, has a broad spectrum of action as an antiepilepsy drug."4.82Divalproex and epilepsy. ( Willmore, LJ, 2003)
"To correlate lamotrigine (LTG) serum concentrations (levels) with tolerability in patients with epilepsy."4.82Correlating lamotrigine serum concentrations with tolerability in patients with epilepsy. ( Adams, DJ; Bazil, CW; Buchsbaum, R; Du, Y; Hager, M; Hirsch, LJ; Morrell, MJ; Resor, SR; Spencer, HT; Straka, T; Weintraub, D, 2004)
"A 12-year-old boy developed pancreatitis, complicated by a pancreatic pseudocyst, as an adverse reaction to valproic acid (VPA) treatment for epilepsy."4.82Pancreatitis, complicated by a pancreatic pseudocyst associated with the use of valproic acid. ( Houben, ML; Stroink, H; van Dijken, PJ; Wilting, I, 2005)
"Shire is developing DP-VPA, a prodrug of valproic acid (VPA) licensed from D-Pharm, for the potential treatment of severe forms of epilepsy, including status epilepticus, acute repetitive seizures in children and possibly manic depression and migraine [242649], [385958]; the drug is also being developed for bipolar disorder and migraine prophylaxis [385862]."4.81DP-VPA D-Pharm. ( Labiner, DM, 2002)
" Intermittent diazepam prophylaxis at times of fever may or may not reduce the recurrence rate significantly, but there is no data to suggest that it improves the long-term outcome, as compared with short-term seizure control, in terms of IQ, cognition, academic progress, motor control, and subsequent epilepsy."4.81[Febrile convulsions, Treatment and prognosis]. ( Knudsen, FU, 2001)
"To provide an overview of the evidence comparing carbamazepine (CBZ) and valproate (VPA) monotherapy for epilepsy, investigating whether existing data support the current practice of preferring CBZ for partial-onset and VPA for generalized-onset seizures."4.81Carbamazepine versus valproate monotherapy for epilepsy: a meta-analysis. ( Chadwick, DW; Clough, H; Hutton, JL; Marson, AG; Williamson, PR, 2002)
"We systematically reviewed and analyzed published and unpublished cases of Stevens-Johnson syndrome (SJS), or toxic epidermal necrolysis (TEN) associated with lamotrigine (LTG) therapy to identify characteristics of these reactions."4.80Lamotrigine-induced severe cutaneous adverse reactions. ( Schlienger, RG; Shapiro, LE; Shear, NH, 1998)
"Carbamazepine and valproate are drugs of first choice for epilepsy."4.80Carbamazepine versus valproate monotherapy for epilepsy. ( Chadwick, DW; Clough, HE; Hutton, JL; Marson, AG; Williamson, PR, 2000)
"The major established drugs used in the management of epilepsy are carbamazepine, valproic acid, phenytoin, phenobarbital, primidone, ethosuximide and benzodiazepine drugs."4.79Established antiepileptic drugs. ( Perucca, E, 1996)
"Trial reports on carbamazepine or valproate monotherapy (Medline-search), and data from the Nijmegen Epilepsy Research Group were analyzed."4.79Adverse effects in epilepsy therapy. Wait and see or go for it? ( Deckers, CL; Hekster, YA; Keyser, A; Lammers, MW; Meinardi, H; Renier, WO, 1997)
"This article provides an analysis of the degree of agreement between in vivo interaction studies performed in patients with epilepsy and healthy individuals, and in vitro studies which identified the cytochromes P450 (CYP) inhibited by felbamate and those involved in its metabolism."4.79Pharmacokinetic interactions with felbamate. In vitro-in vivo correlation. ( Banfield, CR; Glue, P; Levy, RH; Mather, GG; Perhach, JL; Racha, JK, 1997)
"We reported a case of acute pancreatitis occurring during administration of valproic acid for epilepsy."4.78[A case of acute pancreatitis during administration of valproic acid]. ( Ito, S; Kobayashi, K; Kuniya, T; Mimasu, S; Momota, T, 1993)
"An 11 year-old epileptic boy, treated with valproic acid developed after 11 months on therapy a severe acute pancreatitis."4.78[Acute pancreatitis and valproic acid]. ( Bovier Lapierre, M; Jalaguier, E; Kayemba Kay's Kabangu, S, 1991)
" Ethosuximide, valproic acid and clonazepam are used primarily in absence epilepsy."4.77Mechanisms of anticonvulsant drug action. II. Drugs primarily used for absence epilepsy. ( Browning, RA; Faingold, CL, 1987)
"Valproic acid use during pregnancy results in an absolute risk for spina bifida of 1-2%."4.77Teratogen update: valproic acid. ( Lammer, EJ; Oakley, GP; Sever, LE, 1987)
"Valproic acid, a new type of antiepileptic drug, has developed into one of the drugs of first choice in all types of epilepsy with the exception of infantile spasms and partial seizures."4.76Therapeutic monitoring of valproic acid. ( Schobben, F; van der Kleijn, E; Vree, TB, 1980)
"Resistance to valproic acid (VPA) is a major challenge for epilepsy treatment."4.31Overexpression of Homer1b/c induces valproic acid resistance in epilepsy. ( Li, Y; Li, Z; Lu, J; Wang, G; Wang, Y, 2023)
"Valproic acid (VPA)-induced hyperammonemia (HA) is a rare adverse effect reported even at therapeutic VPA levels."4.31Valproic acid-induced hyperammonemia in neuropsychiatric disorders: a 2-year clinical survey. ( Aghamollaii, V; Ghayyem, H; Hassani, M; Hosseini, H; Mayeli, M; Shafie, M; Shakiba, A, 2023)
"Valproic acid (VPA) is a classic medication for several types of epilepsy and mood disorders, and some of its effectiveness and toxicity is associated with metabolites."4.31Determination of valproic acid and its six metabolites in human serum using LC-MS/MS and application to interaction with carbapenems in epileptic patients. ( Chen, R; Dong, L; Hu, N; Jiang, Y; Jiang, Z; Ling, J; Yang, X; Zou, S, 2023)
"Valproic acid is an effective mood stabilizer, registered for the treatment of bipolar disorder and epilepsy."4.31[A severe, reversible encephalopathy after prolonged use of valproic acid]. ( Bloemkolk, D; Gerritse, FL; Rundervoort, RS; van Haaren, PCF, 2023)
"To investigate the efficacy and mechanisms of Dingxian pill combined with valproic acid (VPA) on pentylenetetrazol-induced chronical epilepsy in rats."4.31Efficacy and mechanisms of Dingxian pill combined with valproic acid on pentylenetetrazol-induced chronic epilepsy in rats. ( Dongxiao, QU; Guoyi, LI; Jie, T; Jiwei, C; Liji, C; Limin, Z; Qian, X; Yiqin, GE; Yonghua, X; Yudan, Z, 2023)
"To investigate the antiseizure medication (ASM) doses required to achieve seizure freedom and their correlation with the World Health Organization's defined daily doses (DDDs) in patients aged 16 years or older with newly diagnosed epilepsy."4.31Prescribed antiseizure medication doses and their relation to defined daily doses for achieving seizure freedom in newly diagnosed patients with epilepsy. ( Hersi, H; Peltola, J; Raitanen, J; Saarinen, JT, 2023)
"Findings from this explorative study strengthen the evidence for the warning against the use of valproate in pregnancy and raise concern of risks of specific psychiatric disorders associated with topiramate and levetiracetam."4.31Prenatal Exposure to Antiseizure Medication and Incidence of Childhood- and Adolescence-Onset Psychiatric Disorders. ( Alvestad, S; Bjørk, MH; Christensen, J; Cohen, JM; Dreier, JW; Furu, K; Gissler, M; Igland, J; Leinonen, MK; Sun, Y; Tomson, T; Zoega, H, 2023)
"We present a case of a 29-year-old female with a history of epilepsy who was admitted for convulsive status epilepticus (CSE), which was controlled by intravenous VPA, as well as oral VPA and phenytoin."4.31Valproate-related hyperammonemic encephalopathy with generalized suppression EEG: a case report. ( Liu, X; Peng, X, 2023)
"Valproic acid (VPA) is a relatively safe drug widely used for the treatment of epileptic seizures and mania in bipolar disorder, as well as the prevention of migraine headaches."4.31Acute pancreatitis during valproic acid administration in a patient with vascular dementia, epileptic seizures, and psychiatric symptoms: a case report. ( Harada, M; Hashimoto, R; Igata, R; Ikenouchi, A; Isomoto, N; Konishi, Y; Okamoto, N; Shinkai, T; Yanaga, M; Yoshimura, R, 2023)
"A prospective longitudinal study was conducted to assess the Apo B100/A1 ratio as a marker of cardiovascular risk in children with epilepsy aged 5-14 years on long-term anti-seizure medication monotherapy with either sodium valproate, oxcarbazepine, or levetiracetam."4.31Change in Apo B100/A1 Ratio in Children With Epilepsy on Monotherapy With Sodium Valproate, Oxcarbazepine or Levetiracetam. ( Dhama, A; Kaushik, JS; Lekhwani, S, 2023)
"Dose-adjusted lamotrigine troughs in epilepsy patients with variant UGT2B7 -161C > T or UGT1A4*3 c."4.31Bearing variant alleles at uridine glucuronosyltransferase polymorphisms UGT2B7 -161C > T (rs7668258) or UGT1A4*3 c.142 T > G (rs2011425) has no relevant consequences for lamotrigine troughs in adults with epilepsy. ( Božina, N; Domjanović, IK; Gadže, ŽP; Ganoci, L; Lovrić, M; Romić, ZČ; Šimičević, L; Sporiš, IŠ; Trkulja, V, 2023)
" The aim of this study was to explore the association of SCN1A polymorphisms with efficacy and adverse drug reactions (ADRs) related to valproic acid (VPA) among Chinese children with epilepsy."4.31SCN1A Polymorphisms and Haplotypes Are Associated With Valproic Acid Treatment Outcomes in Chinese Children With Epilepsy. ( Fan, X; Guo, H; He, Y; Li, W; Lu, J; Shen, X; Xia, H; Zhang, J; Zhu, J, 2023)
"Valproic acid (VPA) has long been the most widely used antiepileptic drug (AED) for the treatment of epilepsy, bipolar psychiatric disorders, and migraine."4.31Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo. ( Chalmel, F; Costet, N; Desdoits-Lethimonier, C; Evrard, B; Hug, E; Jégou, B; Kugathas, I; Lavoué, V; Lesné, L; Mazaud-Guittot, S; Raffenne, L; Toupin, M, 2023)
"This study revealed the higher risk of cardiac arrhythmias persists long term in people with epilepsy, especially among those using carbamazepine and valproic acid."4.31Epilepsy and long-term risk of arrhythmias. ( Cai, J; Feng, Z; Huang, P; Liu, P; Lu, J; Lu, Y; Tang, H; Wang, J; Yang, G; Yang, Y; Yu, Q; Yuan, H, 2023)
"Use of valproate and carbamazepine decreased progressively, use of lamotrigine remained relatively static, and the use of levetiracetam increased progressively, whereas the use of topiramate first increased and then fell again, associated with a temporary increase in malformation-associated pregnancy rate."4.31Changes over 24 years in a pregnancy register - Teratogenicity and epileptic seizure control. ( Eadie, M; Graham, J; Hitchcock, A; Lander, C; O'Brien, T; Perucca, P; Vajda, F, 2023)
" In our case series, lamotrigine proved to be less effective and less controllable than other drugs during pregnancy."4.12[Women with epilepsy before and during pregnancy: a case series of outpatient counseling in a tertiary epilepsy center]. ( Bien, CG; Hagemann, A; Knaak, N; Müffelmann, B, 2022)
"Valproic acid (VPA) and levetiracetam (LEV) are used in epilepsy treatment."4.12Successful Treatment of Symptomatic Epilepsy with Oral Valproic Acid and Levetiracetam in a Patient with Short-bowel Syndrome. ( Hayashi, M; Iijima, A; Isozaki, R; Kurishima, A; Shimozato, R; Shioda, T, 2022)
"Valproic acid (VPA) is used for the treatment of epilepsy and bipolar disorder (BD)."4.12Long-term use of valproic acid reduced mortality in bipolar disorder patients in a Taiwanese population: An association analysis using the national health insurance research database (NHIRD). ( Hsieh, TC; Lin, CC; Wu, LS, 2022)
"To assess knowledge among neurologists in Sweden and Norway on the restrictions issued by the European Medicines Agency (EMA) regarding use of valproic acid (VPA) to female patients of childbearing potential, their use of the pregnancy prevention programme and their VPA prescription habits."4.12Valproate Restrictions in Sweden and Norway: Online survey suggests implementation deficit. ( Sveberg, L; Taubøll, E; Tomson, T; Zelano, J, 2022)
" In most Australian women starting therapy for epilepsy initiating treatment with levetiracetam monotherapy may offer the best chance of such a desirable outcome to a future pregnancy, yet to be confirmed."4.12Achieving neurologically desirable outcomes to pregnancy in women with epilepsy. ( Eadie, MJ; Graham, JE; Hitchcock, AE; Lander, CM; O'Brien, TJ; Perucca, P; Vajda, FJE, 2022)
"In a nation-wide population-based longitudinal register linkage study for the first time 1) to investigate long-term response to lithium in patients with bipolar disorder with and without comorbid epilepsy, and 2) within patients with bipolar disorder and comorbid epilepsy to compare differences in responses between lithium, valproate and lamotrigine."4.12Response to lithium and anticonvulsants among patients with bipolar disorder with and without comorbid epilepsy - A nation-wide population-based longitudinal study. ( Budtz-Jørgensen, E; Gerds, T; Kessing, LV; Ziersen, SC, 2022)
" Here we examine the effects of valproic acid (VA) plus 4-phenylbutyric acid (4-PBA) on abnormal electrical brain activity, ER stress and apoptosis in acute seizures induced by pentylenetetrazole (PTZ)."4.124-Phenylbutyric Acid Plus Valproic Acid Exhibits the Therapeutic and Neuroprotective Effects in Acute Seizures Induced by Pentylenetetrazole. ( Amanvermez, R; Arslan, G; Gün, S; Rzayev, E; Tiryaki, ES, 2022)
"AbstractThe aim of this study was to explore the effect of lamotrigine (LTG) on blood ammonia level in patients with epilepsy and identify risk factors affecting blood ammonia level."4.12Risk factors of elevated blood ammonia level in epilepsy patients treated with lamotrigine. ( Chen, J; Chen, X; Chen, Y; Miao, J; Wang, R; Zeng, J; Zhuang, X, 2022)
" Consecutive adolescent patients with epilepsy aged 11-17 years with partial or generalized seizures, treated with either levetiracetam or valproic acid for at least 6 months, and healthy controls were recruited."4.12Irritability and its relationship with psychosocial symptoms and quality of life in adolescents with epilepsy receiving levetiracetam therapy: A case-control study. ( Tekin, E; Tekin, U; Uçar, HN, 2022)
"The present study identifies a significant positive association between ASM and LUTI incidence and antibiotic prescriptions in patients with epilepsy treated with pregabalin, whereas a protective effect was found for carbamazepine in women only."4.12Association between anti-seizure medication and the risk of lower urinary tract infection in patients with epilepsy. ( Ehrenberg, C; Gremke, N; Kalder, M; Kostev, K; Möller, L; Printz, M, 2022)
"This study aimed to explore the effect of concomitant use of Furosemide (FRS) and Valproic acid (VPA), demonstrating anti-inflammation efficacy, on epilepsy, and its underlying mechanism."4.12The effect of valproic acid and furosemide on the regulation of the inflammasome complex (NLRP1 and NLRP3 mRNA) in the brain of epileptic animal model. ( Abdolmaleki, Z; Faedmaleki, F; Samadianzakaria, A, 2022)
"To compare the hazard for all-cause mortality and mortality due to heart failure (HF) between valproate (VPA) and levetiracetam (LEV)/lamotrigine (LTG) users in patients aged ≥ 65 with comorbidities of epilepsy and HF."4.12The Relationship Between Valproate and Lamotrigine/Levetiracetam Use and Prognosis in Patients With Epilepsy and Heart Failure: A Danish Register-Based Study. ( Gardella, E; Kragholm, K; Liang, D; Polcwiartek, C; Sessa, M, 2022)
"To study the association between CYP2C19*2 (681 G > A) and UGT1A6*2 (552A > C) polymorphisms on Valproic acid (VPA)-induced weight gain in People with epilepsy (PWE)."4.02CYP2C19 & UGT1A6 genetic polymorphisms and the impact on Valproic acid-induced weight gain in people with epilepsy: Prospective genetic association study. ( Kamalanathan, S; Kesavan, R; Mani, B; Nair, PP; Narayan, SK; Sekhar, A, 2021)
"A retrospective chart review conducted at King Abdulaziz University Hospital, Jeddah, Kingdome of Saudi Arabia, for children below 2 years of age diagnosed with epilepsy and treated with valproic acid from January 2016 to January 2020."4.02Valproic acid for children below 2 years of age with epilepsy. ( Alfawaz, NS; Almahmudi, SM; Alrabghi, MO; Bin Mahfouz, MM; Muthaffar, OY, 2021)
"Children aged 1 to 12 years, diagnosed with epilepsy (generalized or focal seizures), treated with valproate (n = 40) and valproate with add-on levetiracetam (n = 40) were included."4.02Effect of valproate and add-on levetiracetam on inflammatory biomarkers in children with epilepsy. ( Gupta, R; Halder, S; Kar, R; Labh, R; Narang, M, 2021)
"Prenatal uptake of valproic acid (VPA) was associated with increased risk of fetal cardiac anomalies and autism spectrum disorder (ASD), but uptake of VPA is considered the only effective treatment for epilepsy and other neurological disorders."4.02Effect of Valproic Acid on Maternal - Fetal Heart Rates and Coupling in Mice on Embryonic day 15.5 (E15.5). ( Fukase, M; Kasahara, Y; Khandoker, A; Kimura, Y; Nakanishi, K; Saito, M; Suzuki, A; Widatalla, N; Yoshida, C, 2021)
" The aim of our study was to investigate the effects of valproic acid and carbamazepine monotherapy used in the treatment of epilepsy patients on serum adiponectin and carnitine levels."4.02The correlation between carbamazepine and valproic acid monotherapy with serum adiponectin and carnitine. ( Ceylan, M; İyigün, İ; Kızıltunç, A; Şimşek, F, 2021)
"The purpose of this study was to establish a protein binding model of unbound valproic acid (VPA) based on Chinese pediatric patients with epilepsy and provide a reference for clinical medication."4.02Population pharmacokinetics of unbound valproic acid in pediatric epilepsy patients in China: a protein binding model. ( Gu, X; Hu, Y; Jiao, Z; Li, Z; Ma, M; Peng, Q; Sheng, C; Yu, S; Zhou, B; Zhu, M, 2021)
" In the pharmacodynamic interaction study, seizures were induced using pentylenetetrazole (PTZ) (60 mg/kg, i."4.02Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats. ( Agarwal, A; Arora, R; Ganeshan N, S; Gupta, YK; Kaleekal, T; Kumar, R; Sarangi, SC, 2021)
" In this study, we examined the effect of both acute and chronic treatment with moclobemide on seizures and the action of first-generation antiepileptic drugs: valproate, carbamazepine, phenobarbital and phenytoin."4.02Acute and chronic treatment with moclobemide, a reversible MAO-inhibitor, potentiates the antielectroshock activity of conventional antiepileptic drugs in mice. ( Banach, M; Borowicz-Reutt, KK, 2021)
"Prenatal exposure to the antiepileptic drug (AED) valproic acid (VPA) is associated with an increased risk of impaired postnatal neurodevelopment, including autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD)."4.02Prenatal valproate exposure and adverse neurodevelopmental outcomes: Does sex matter? ( Anderson, A; Graham, J; Hitchcock, A; Honybun, E; Malpas, CB; O'Brien, TJ; Perucca, P; Rayner, G; Thwaites, R; Vajda, FJE, 2021)
" Exanthema as especially clinically relevant adverse drug event was rightly chosen for carbamazepine by 18 (8%) and for lamotrigine by 12 (5%) participants."4.02Knowledge of epilepsy among German pharmacists. ( Bertsche, A; Bertsche, T; Herziger, B; Jeschke, S; Müller, RM; Neininger, MP, 2021)
"We measured carnitine levels before and after pivalate-conjugated antibiotic (PCA) use in six patients with epilepsy who were prescribed valproate (VPA)."4.02Carnitine supplementation prevents carnitine deficiency caused by pivalate-conjugated antibiotics in patients with epilepsy prescribed valproate. ( Azuma, Y; Iwayama, H; Kurahashi, H; Numoto, S; Okumura, A, 2021)
"39 years) with epilepsy, well controlled by monotherapy with levetiracetam, valproic acid, ethosuximide, oxcarbazepine or carbamazepine and 45 age/sex-matched controls."4.02Effects of antiseizure monotherapy on visuospatial memory in pediatric age. ( Coppola, G; Di Bonaventura, C; Donadio, S; Operto, FF; Padovano, C; Pastorino, GMG; Scuoppo, C; Vivenzio, V, 2021)
"We explored the potential effects of genetic variations on the concentration to dose ratio (CDR) of valproic acid (VPA) in paediatric epilepsy patients."4.02Influence of ( Du, Z; Liu, M; Wang, J; Xu, H; Xu, Q; Zhao, P, 2021)
"Overall, serum free carnitine levels showed significant negative correlations with epilepsy duration, VPA treatment duration, daily VPA dose, and blood VPA concentration."4.02Factors associated with blood carnitine levels in adult epilepsy patients with chronic valproic acid therapy. ( Miyaoka, H; Saito, M; Takizawa, T, 2021)
"Although several studies have indicated that valproate (VPA) and oxcarbazepine (OXC) cause reproductive endocrine disorders and sexual dysfunction, there remains some controversy regarding these issues in males with epilepsy."4.02A Comparative Study of the Effects of Valproate and Oxcarbazepine on Sexual Function, Sperm Quality, and Sex Hormones in Males with Epilepsy. ( Chen, L; Guo, Y; Sun, H; Wu, D; Yu, L; Zhu, Q, 2021)
"Epilepsy patients were followed up at the Antalya Training and Research Hospital Department of Neurology, Epilepsy Outpatient Clinic who were at high risk for osteoporosis (use of valproic acid [VPA] and enzyme-inducing drugs, using any AED for over 5 years, and postmenopausal women) and were evaluated using a screening protocol."4.02Management of bone metabolism in epilepsy. ( Abidin, E; Fatma, G; Uçan Tokuç, FE; Yasemin, GB, 2021)
"We measured the serum-free carnitine (FC), VPA, aspartate aminotransferase, alanine aminotransferase, amylase, and ammonia levels, and the platelet count, in 69 patients with childhood-onset epilepsy treated with VPA."4.02Effects of l-carnitine supplementation in patients with childhood-onset epilepsy prescribed valproate. ( Azuma, Y; Iwayama, H; Kurahashi, H; Numoto, S; Okumura, A; Takagi, M, 2021)
" Importantly, the isobolographic analysis showed that a combination of AS-1 and valproic acid (VPA) at the fixed ratio of 1:1 displayed a supra-additive (synergistic) interaction against PTZ-induced seizures in mice."3.96N-Benzyl-(2,5-dioxopyrrolidin-1-yl)propanamide (AS-1) with Hybrid Structure as a Candidate for a Broad-Spectrum Antiepileptic Drug. ( Abram, M; Andres-Mach, M; Esguerra, CV; Gawel, K; Jakubiec, M; Kamiński, K; Latacz, G; Lubelska, A; Nieoczym, D; Pieróg, M; Rapacz, A; Socała, K; Szewczyk, A; Szulczyk, B; Wlaź, P; Zagaja, M; Łuszczki, JJ, 2020)
"The aim of the study was to investigate the risk of subclinical atherosclerosis independent from obesity and high blood lipid levels in pediatric patients with idiopathic epilepsy receiving valproic acid or levetiracetam monotherapy by evaluating carotid intima-media thickness (CIMT) and Epicardial adipose tissue thickness (EATT)."3.96Effects of valproic acid and levetiracetam monotherapy on carotid intima-media and epicardial adipose tissue thickness in non-obese children with epilepsy. ( Karatoprak, E; Tosun, O, 2020)
" Epilepsy-associated comorbid depression was evaluated by tail suspension test, sucrose preference test, and plasma corticosterone levels, whereas epilepsy-associated memory deficit condition was assessed by step-through paradigm, Morris water maze, and nitrite levels."3.96Exploring the ameliorative role of α7 neuronal nicotinic acetylcholine receptor modulation in epilepsy and associated comorbidities in post-PTZ-kindled mice. ( Goel, RK; Kaur, S; Sharma, NK, 2020)
"We sought to explore the effects of sodium valproate combined with lamotrigine on quality of life and serum inflammatory factors in patients with poststroke secondary epilepsy."3.96Effects of Sodium Valproate Combined with Lamotrigine on Quality of Life and Serum Inflammatory Factors in Patients with Poststroke Secondary Epilepsy. ( Guo, D; Hao, F; Li, X; Liu, X; Sun, J; Tang, W; Tao, S, 2020)
"The aim of the study was to investigate how age and genetic polymorphisms of UGT1A6 and UGT2B7 contribute to the concentrations of valproic acid (VPA) and its hepatotoxic metabolites in Chinese pediatric patients with epilepsy."3.96Impact of Age and Genotype on Serum Concentrations of Valproic Acid and Its Hepatotoxic Metabolites in Chinese Pediatric Patients With Epilepsy. ( Chen, Y; Li, G; Wang, M; Zhao, L; Zhao, M, 2020)
"Here, we present a multicenter series of patients with developmental and epileptic encephalopathies (DEE) and related electroclinical patterns (REP) other than Lennox-Gastaut syndrome (LGS) who were treated with rufinamide as add-on therapy."3.96Rufinamide as add-on therapy in children with epileptic encephalopathies other than Lennox-Gastaut syndrome: A study of 34 patients. ( Caraballo, RH; Espeche, A; Fasulo, L; Galichio, S; Pociecha, J; Reyes, G; Semprino, M, 2020)
"These findings suggest that carnitine deficiency is associated with the VPA dose and the serum VPA level in patients with bipolar disorder."3.96Association Between the Serum Carnitine Level and Ammonia and Valproic Acid Levels in Patients with Bipolar Disorder. ( Ishioka, M; Kubo, K; Miyazaki, K; Nakagami, T; Shimoda, K; Sugawara, N; Tarakita, N; Yasui-Furukori, N; Yokoyama, S, 2020)
"Dose individualization is essential in epilepsy treatment, especially in antiepileptic drugs that present high interindividual variability such as lamotrigine."3.96Dosing Recommendations Based on Population Pharmacokinetics of Lamotrigine in Mexican Adult Patients With Epilepsy. ( Chávez-Castillo, CE; Medellín-Garibay, SE; Milán-Segovia, RDC; Rodríguez-Leyva, I; Romano-Moreno, S, 2020)
"Female sex, refractoriness, and clonazepam use may be risk factors for depression after epilepsy diagnosis."3.96Factors associated with depression in people with epilepsy: a retrospective case-control analysis. ( Chang, RSK; Ho, PH; Leung, IYH; Leung, WCY, 2020)
"In January 2019, a new plant-derived purified cannabidiol preparation, approved by the US Food and Drug Administration, became commercially available for patients ≥2 years old with Lennox-Gastaut syndrome or Dravet syndrome."3.96Thrombocytopenia in pediatric patients on concurrent cannabidiol and valproic acid. ( Carlson, M; Dang, LT; Fedak Romanowski, EM; Joshi, SM; Leber, SM; McNamara, NA; Robertson, P; Shellhaas, RA; Smith, GC; Sturza, J; Ziobro, JM, 2020)
"Nocturnal enuresis is one of the side effects of valproic acid treatment, and generally underdiagnosed by clinicians."3.96Sleep Architecture in Valproate-Induced Nocturnal Enuresis in Primary School and Preschool Children. ( Abdelsalam, M; Bendary, L; Egila, H; Elsherief, M; Esmael, A, 2020)
"To evaluate the changes of epileptiform activity index (EAI) as a measure of the efficacy and tolerability of treatment with valproic acid (VA) in patients with newly-diagnosed generalized and focal epilepsy."3.96[Dynamics of epileptiform activity, efficacy and tolerability of valproic acid in adults and adolescents with newly-diagnosed epilepsy]. ( Karlov, VA; Kozhokaru, AB; Orlova, AS; Pushkar, TN; Vlasov, PN, 2020)
"Due to the narrow therapeutic window of valproic acid (VPA), grievous adverse reactions such as hepatotoxicity, nephrotoxicity may occur in patients with epilepsy for a long time."3.96Valproic acid concentration and biochemical indexes in epilepsy outpatients during monotherapy or combination therapy. ( Luo, J; Ma, H; Pan, J; Wang, C; Wang, P; Yang, X, 2020)
"This study was conducted to explore the influence of genetic variations on responsiveness to valproic acid (VPA) monotherapy among Chinese children with epilepsy."3.96Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children. ( Du, Z; Liu, M; Mao, J; Wang, J; Xu, H; Xu, Q; Zhao, P, 2020)
"The aim of this study was to evaluate the effects of valproate (VPA), lamotrigine (LTG), and levetiracetam (LEV) on bone turnover and bone mineral density (BMD) in newly diagnosed adult patients with epilepsy."3.96Effects of valproate, lamotrigine, and levetiracetam monotherapy on bone health in newly diagnosed adult patients with epilepsy. ( Guo, Y; Huang, Y; Lin, Z; Yu, L, 2020)
"The aim of the study was to assess whether, male patients with epilepsy, switching from valproic acid (VPA) to levetiracetam (LEV) or lamotrigine (LMG) critically improves sperm counts and parameters, increasing chance of patients' female partners to spontaneously conceive."3.96An open study of valproate in subfertile men with epilepsy. ( Georgiou, I; Kostoulas, C; Markoula, S; Siarava, E; Zikopoulos, A, 2020)
"Phenobarbital and sodium valproate are broad spectrum and inexpensive antiepileptic drugs that are used to treat convulsive epilepsy."3.91Efficacy of phenobarbital and sodium valproate in treating convulsive epilepsy in rural northeast China. ( Li, J; Li, N; Lin, W; Yang, D; Zhao, D, 2019)
" The agents tested were: alpha-lactoalbumin (ALAC), a whey protein rich in tryptophan, effective in some animal models of epilepsy and on colon/intestine inflammation, valproic acid (VPA), an effective antiepileptic drug in this seizure model, mesalazine (MSZ) an effective aminosalicylate anti-inflammatory treatment against ulcerative colitis and sodium butyrate (NaB), a short chain fatty acid (SCFA) normally produced in the intestine by gut microbiota, important in maintaining gut health and reducing gut inflammation and oxidative stress."3.91Intestinal inflammation increases convulsant activity and reduces antiepileptic drug efficacy in a mouse model of epilepsy. ( Avagliano, C; Calignano, A; Citraro, R; Constanti, A; De Caro, C; De Sarro, G; di Cesare Mannelli, L; Ghelardini, C; Leo, A; Mainardi, P; Nesci, V; Russo, E; Striano, P, 2019)
" A 13-year-old girl with genetically confirmed Pitt-Hopkins syndrome with uncontrolled seizures, while on treatment with levetiracetam and valproic acid, was started on perampanel, reaching seizure control."3.91Perampanel-induced hair curling in a patient with epilepsy associated with Pitt Hopkins syndrome. ( Calle-Lopez, Y; Knight, EP; Kotagal, P, 2019)
"A 24-year-old woman with a long-standing history of polio and a 2-year history of epilepsy developed a serious ADR after repeated exposure to oral clonazepam combined with sodium valproate that manifested as myotoxicity and elevated levels of creatine phosphokinase."3.91A serious adverse drug reaction probably induced by clonazepam: a case report of myotoxicity. ( Han, X; Wang, J, 2019)
" This study evaluated the efficacy of sodium valproate encapsulated in nanoparticles in pentylenetetrazole (PTZ) induced acute and kindling models of seizures in male Wistar rats."3.91Evaluation of sodium valproate loaded nanoparticles in acute and chronic pentylenetetrazole induced seizure models. ( Dinda, AK; Gupta, YK; Kottarath, SK; Meenu, M; Reeta, KH, 2019)
"The objective of this study was to evaluate the long-term safety, tolerability, and efficacy of cannabidiol in children with epilepsy."3.91Long-Term Safety, Tolerability, and Efficacy of Cannabidiol in Children with Refractory Epilepsy: Results from an Expanded Access Program in the US. ( Caminha Nunes, E; Cilio, MR; Oldham, MS; Rahdari, S; Sands, TT; Tilton, N, 2019)
"The aims of this study were to identify the influencing factors such as gender, age, dose and combinations of other antiepileptic drugs (AEDs), especially in triple combinations on the pharmacokinetic of Lamotrigine (LTG) in epilepsy patients of Northwest Chinese Han population."3.91The influence of concomitant antiepileptic drugs on lamotrigine serum concentrations in Northwest Chinese Han population with epilepsy. ( Han, X; Huang, J; Lv, J; Ma, L; Nie, X; Peng, L; Wang, J; Xia, L; Zan, X, 2019)
"Irritability has been described as a frequent adverse event in patients affected by epilepsy and treated with perampanel (PER), levetiracetam (LEV), and less frequently with valproic acid (VPA)."3.91Preliminary evidence about irritability in patients with epilepsy treated by perampanel as first add-on therapy compared to levetiracetam and valproic acid. ( Assogna, M; Canevini, MP; Izzi, F; Liguori, C; Mercuri, NB; Placidi, F; Turner, K, 2019)
"There is a large inter-individual variation in the efficacy of valproic acid (VPA) against epilepsy."3.91SCN1A and SCN2A polymorphisms are associated with response to valproic acid in Chinese epilepsy patients. ( Chen, X; Li, H; Lin, C; Luo, J; Shi, L; Wen, Z; Zhang, Z; Zhu, M, 2019)
"This study measured the serum carnitine levels in patients with epilepsy and determined the factors contributing to low carnitine levels."3.91Serum carnitine levels of children with epilepsy: Related factors including valproate. ( Iwayama, H; Kurahashi, H; Numoto, S; Okumura, A, 2019)
"Valproic acid (VPA) is used as one of the first-line antiepileptic drugs to control seizure in epilepsy patients."3.91Correlation of MCT1 and ABCC2 gene polymorphisms with valproic acid resistance in patients with epilepsy on valproic acid monotherapy. ( Chen, J; Chen, Z; Huang, M; Li, H; Qin, J; Ruan, H; Su, Q; Wang, X; Zhou, L; Zhou, S; Zhou, Y, 2019)
"Valproic acid (VPA) is currently one of the four most often prescribed antiepileptic drugs (AEDs) in pregnancy."3.91Valproic acid concentrations in nursing mothers, mature milk, and breastfed infants in monotherapy and combination therapy. ( Brozmanova, H; Grundmann, M; Kacirova, I, 2019)
" Pentylenetetrazole- (PTZ) and pilocarpine-induced seizures are well-established models of human epilepsy."3.91The effect of co-administration of pentylenetetrazole with pilocarpine: New modified PTZ models of kindling and seizure. ( Jand, A; Mousavi-Hasanzadeh, M; Palizvan, MR; Rezaeian-Varmaziar, H; Shafaat, O, 2019)
"Valproic acid has a long-standing reputation of effectively treating the symptoms of not only epilepsy but also psychiatric conditions."3.91Valproic acid potently inhibits interictal-like epileptiform activity in prefrontal cortex pyramidal neurons. ( Nurowska, E; Pasierski, M; Szulczyk, B, 2019)
"Our aim was to investigate any adverse effects of long-term valproic acid (VPA) therapy on bone biochemical markers in ambulatory children and adolescents with epilepsy, and the possible benefits of vitamin D supplementation on the same markers."3.91Vitamin D supplementation and bone markers in ambulatory children on long-term valproic acid therapy. A prospective interventional study. ( Challa, A; Cholevas, V; Nakou, I; Papassava, M; Siomou, E; Tzoufi, M, 2019)
" Reported is a 16-year-old man with intractable epilepsy and an 11-year history of chronic hyponatraemia (126-135 mEq/L) due to valproic acid induced syndrome of inappropriate antidiuresis who sustained low-impact fragility fractures and had evidence of osteopaenia on both X-ray and dual energy X-ray absorptiometry (DEXA)."3.91Fragility fractures and reversible osteopaenia due to chronic hyponatraemia in an adolescent male. ( Ayus, JC; Moritz, ML; Patel, M, 2019)
"The aim of this study is to evaluate if valproate (VPA) and levetiracetam (LEV) as monotherapy are associated with vitamin D deficiency among children with epilepsy."3.88Vitamin D deficiency in children with epilepsy taking valproate and levetiracetam as monotherapy. ( Aguilera-Albesa, S; Durá-Travé, T; Gallinas-Victoriano, F; Malumbres-Chacón, M; Moreno-Gónzalez, P; Yoldi-Petri, ME, 2018)
"The aim of this study was to investigate the effect of carbamazepine (CBZ) and sodium valproate (VPA) monotherapy on sexual functions, sex hormones, and semen analysis and quality in male patients with epilepsy."3.88Evaluation of sex hormones and sperm parameters in male epileptic patients. ( Colak, A; Köse, C; Ocek, L; Sarıteke, A; Tarhan, H; Uludağ, FI; Zorlu, F; Zorlu, Y, 2018)
"To assess the effect of monotherapy with Carbamazepine (CBZ) and Sodium valproate (VPA) on serum 25-OH Vitamin D levels in children with epilepsy compared to controls."3.88Vitamin D Deficiency in Ambulant Children on Carbamazepine or Sodium Valproate Monotherapy. ( Devadathan, K; Mohammed Kunju, PA; Muthubeevi, S; Pillai, JP; Sasidharan, B; Sreedharan, M; Vasumathy Amma, MA, 2018)
"A total of 304 patients with epilepsy, aged 18-70 years, were divided into a lamotrigine monotherapy group and groups receiving lamotrigine with AEDs that act as enzyme inducers, enzyme inhibitors, or both."3.88Effect of antiepileptic drug comedication on lamotrigine concentrations. ( Božina, N; Čajić, I; Klarica Domjanović, I; Lovrić, M; Petelin Gadže, Ž, 2018)
"To explore the incidence and independent risk-factors of secondary carnitine deficiency in Chinese children with epilepsy on valproate monotherapy."3.88Carnitine Deficiency in Chinese Children with Epilepsy on Valproate Monotherapy. ( Hong, J; Qiliang, L; Wenqi, S, 2018)
" The frequency of number of seizures/week was higher in the carbamazepine cohort compared to valproic acid cohort."3.88Carbamazepine Verses Valproic Acid as Monotherapy in Epileptic Patients. ( Ali, N; Nazish, H; Shakir, S, 2018)
"In the study, the effect of valproic acid on serum free/acylcarnitine levels and left ventricular systolic function in pediatric patients with idiopathic epilepsy receiving valproic acid was investigated."3.88Evaluation ofserum free carnitine/acylcarnitine levels and left ventricular systolic functions in children with idiopathic epilepsy receiving valproic acid. ( Celik, H; Ince, H; Kulhas Celik, I; Sungur, M; Tasdemir, HA, 2018)
"Adults with epilepsy on lamotrigine monotherapy (n = 131) or lamotrigine + valproate treatment (n = 74) were genotyped and steady-state lamotrigine and valproate morning troughs were determined as a part of routine therapeutic drug monitoring."3.88Interaction between ABCG2 421C>A polymorphism and valproate in their effects on steady-state disposition of lamotrigine in adults with epilepsy. ( Božina, N; Čajić, I; Ganoci, L; Klarica Domjanović, I; Lovrić, M; Petelin-Gadže, Ž; Trkulja, V, 2018)
"This study was aimed at identifying genetic and non-genetic risk factors for valproic acid (VPA)-induced hyperammonaemia in Chinese paediatric patients with epilepsy."3.88Risk Factors for Valproic Acid-induced Hyperammonaemia in Chinese Paediatric Patients with Epilepsy. ( Li, X; Zhang, T; Zhao, L; Zhu, X, 2018)
"Evaluation of biochemical derangements related to metabolic syndrome in epileptic patients on treatment with Valproic acid."3.88Biochemical derangements related to metabolic syndrome in epileptic patients on treatment with valproic acid. ( Bobby, Z; Nisha, Y; Wadwekar, V, 2018)
"The purpose of this study was to determine the effect of lamotrigine (LTG) and levetiracetam (LEV) as mono- and polytherapy on biochemical markers of bone turnover and bone mineral density in Egyptian adult patients with epilepsy."3.88Levetiracetam and lamotrigine effects as mono- and polytherapy on bone mineral density in epileptic patients. ( Akef, GH; Allah, HMS; El-Haggar, SM; Mostafa, TM, 2018)
"Valproic acid (VPA) provides a common treatment for both epilepsy and bipolar disorder; however, common cellular mechanisms relating to both disorders have yet to be proposed."3.88Diacylglycerol kinase (DGKA) regulates the effect of the epilepsy and bipolar disorder treatment valproic acid in ( Kelly, E; Sharma, D; Wilkinson, CJ; Williams, RSB, 2018)
"This 13-year-old girl with autism and intractable epilepsy experienced increased seizures; her valproic acid dose was increased and other antiepileptic drugs were administered."3.85Burst Suppression Pattern on Electroencephalogram Secondary to Valproic Acid-Induced Hyperammonemic Encephalopathy. ( Cherian, KA; Legatt, AD, 2017)
"Because the pharmacokinetic evaluation of valproic acid (VPA) based on total drug concentration may be misleading in patients with hypoalbuminemia as a result of saturable protein binding and saturable metabolism, we sought to investigate the usefulness of therapeutic drug monitoring of unbound VPA concentration in a real-world clinical context, with a focus on clinically significant neurologic adverse outcomes."3.85Clinical Importance of Monitoring Unbound Valproic Acid Concentration in Patients with Hypoalbuminemia. ( Doré, M; Frenette, AJ; San Juan, AE; Williamson, D, 2017)
"Levetiracetam, a widely used antiepileptic drug in children, has been associated with psychosocial and behavioral problems, which are also influenced by epilepsy variables, including duration or seizure frequency."3.85The influence of levetiracetam on psychosocial and behavioral functioning in children: A case-control and follow-up study. ( Aydınlı, N; Bektaş, G; Çalışkan, M; Özkan, MU; Özmen, M; Tekin, U; Yıldız, EP, 2017)
"A limited number of anti-epileptic drugs accounted for the treatment of a majority of new patients with epilepsy (carbamazepine, lamotrigine and valproate accounted for more than 70%)."3.85Patterns of antiepileptic drug prescription in Sweden: A register-based approach. ( Berggren, F; Berling, P; Bolin, K; Gauffin, H; Landtblom, AM; Morberg, S, 2017)
"The aim of the study is to evaluate the association between genetic polymorphisms and valproic acid (VPA) concentration to dose ratio in children with epilepsy on VPA monotherapy."3.85Genetic polymorphisms and valproic acid plasma concentration in children with epilepsy on valproic acid monotherapy. ( Fang, F; Feng, W; Gao, B; Mei, S; Wu, X; Yang, W; Yu, Y; Zhao, Z; Zhu, L, 2017)
"An adolescent male with difficult to control epilepsy was admitted for impaired hepatic function while on valproic acid therapy."3.85Thrombotic microangiopathy associated with Valproic acid toxicity. ( Bohan, TP; Erikson, CL; Hebert, SA; Swinford, RD, 2017)
" He was found to have high anion gap metabolic acidosis with significantly elevated lactate along with an elevated osmolal gap and calcium oxalate crystals in his urine."3.85Two gaps too many, three clues too few? Do elevated osmolal and anion gaps with crystalluria always mean ethylene glycol poisoning? ( Abu Sitta, E; Gaddam, M; Kanzy, A; Velagapudi, RK, 2017)
"Sotalol as a drug blocking β-receptors and potassium KCNH2 channels may interact with different substances that affect seizures."3.85Sotalol enhances the anticonvulsant action of valproate and diphenylhydantoin in the mouse maximal electroshock model. ( Banach, M; Borowicz-Reutt, KK; Popławska, M, 2017)
"There have been several reports of congenital malformations in the offspring of mothers who took valproic acid (VPA) during pregnancy as a treatment for epilepsy."3.85Fetal Valproate Syndrome. ( Bulut, C; Çaksen, H; Mutlu-Albayrak, H, 2017)
" Owing to the major role of neuronal nitric oxide synthase (nNOS) in brain and ineffectiveness of antiepileptic drugs (AEDs) in restoring nitrosative stress, the present study was envisaged to evaluate the adjuvant nNOS inhibitor, 7-nitroindazole (7-NI) with valproic acid for combined treatment of epilepsy and associated depression."3.85Adjuvant neuronal nitric oxide synthase inhibition for combined treatment of epilepsy and comorbid depression. ( Goel, RK; Singh, T, 2017)
"This retrospective longitudinal study included 85 VPA-treated and 93 carbamazepine (CBZ)-treated (as a reference) young patients with epilepsy."3.83Cytochrome P450 2C19 polymorphisms and valproic acid-induced weight gain. ( Ishitsu, T; Kajiwara, A; Nakagawa, K; Noai, M; Oniki, K; Saruwatari, J; Soraoka, H; Tanamachi, Y, 2016)
"Valproic acid (VPA) is widely used in the treatment of children with epilepsy."3.83Effects of UGT2B7 Genetic Polymorphisms on Serum Concentrations of Valproic Acid in Chinese Children With Epilepsy Comedicated With Lamotrigine. ( Dong, Y; Guo, Y; Liang, M; Meng, H; Qiu, F; Wang, Q; Yun, W; Zhao, L, 2016)
"To confirm the hypothesis suggested above, a combined analysis of survival association of antiepileptic drug use at the start of chemoradiotherapy with temozolomide was performed in the pooled patient cohort (n = 1,869) of four contemporary randomized clinical trials in newly diagnosed glioblastoma: AVAGlio (Avastin in Glioblastoma; NCT00943826), CENTRIC (Cilengitide, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma and Methylated Gene Promoter Status; NCT00689221), CORE (Cilengitide, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma and Unmethylated Gene Promoter Status; NCT00813943), and Radiation Therapy Oncology Group 0825 (NCT00884741)."3.83Does Valproic Acid or Levetiracetam Improve Survival in Glioblastoma? A Pooled Analysis of Prospective Clinical Trials in Newly Diagnosed Glioblastoma. ( Chinot, O; Cloughesy, T; Gilbert, MR; Gorlia, T; Happold, C; Hegi, M; Mehta, MP; Nabors, LB; Perry, JR; Pugh, SL; Reardon, DA; Roth, P; Stupp, R; Weller, M; Wick, W, 2016)
"To identify the factors influencing topiramate pharmacokinetics (PK) in a large population of adult patients with epilepsy using population PK analysis."3.83Factors influencing topiramate clearance in adult patients with epilepsy: A population pharmacokinetic analysis. ( Bae, EK; Jang, IJ; Kim, TJ; Lee, J; Lee, KJ; Lee, SK; Moon, J; Shin, D; Shin, JW; Shin, YW, 2016)
"Carbamazepine is one of the three most frequently prescribed antiepileptic drugs in pregnancy."3.83Concentrations of carbamazepine and carbamazepine-10,11-epoxide in maternal and umbilical cord blood at birth: Influence of co-administration of valproic acid or enzyme-inducing antiepileptic drugs. ( Brozmanova, H; Grundmann, M; Kacirova, I, 2016)
"Studies of the effect of oxcarbazepine (OXC) on body growth of children with epilepsy are rare and their results are controversial."3.83Weight gain in children on oxcarbazepine monotherapy. ( Attilakos, A; Garoufi, A; Katsarou, E; Koemtzidou, E; Kossiva, L; Soldatou, A; Tsentidis, C; Vartzelis, G, 2016)
"Although it has been reported that some antiepileptic drugs have inducing or inhibiting effects on lamotrigine (LTG) clearance, whether they have the same effects in Asian epilepsy patients as in those in other countries has not been clarified, especially in children."3.83The effects of co-medications on lamotrigine clearance in Japanese children with epilepsy. ( Abe, S; Azuma, Y; Ishihara, N; Ito, Y; Itomi, K; Kidokoro, H; Kojima, S; Kurahashi, H; Kurahashi, N; Maruyama, K; Natsume, J; Negoro, T; Okumura, A; Suzuki, M; Takeuchi, T; Tsuji, T; Watanabe, K; Yamada, K; Yamamoto, H, 2016)
"The aim of this study was to compare the risk of metabolic syndrome (MS) and evaluate related factors for MS among people with epilepsy treated with valproate (VPA) or carbamazepine (CBZ)."3.83Metabolic syndrome and anticonvulsants: A comparative study of valproic acid and carbamazepine. ( Haldre, S; Kõks, S; Rakitin, A, 2016)
"To identify potential risk factors for the development of subclinical hypothyroidism following long-term valproic acid monotherapy in children with epilepsy."3.83Duration of valproic acid monotherapy correlates with subclinical thyroid dysfunction in children with epilepsy. ( Bogićević, D; Ilić, V; Ješić, M; Kovačević, M; Kovačević, SV; Miljković, B; Prostran, M, 2016)
"The alterations observed in body composition with valproic acid in contrast to other AEDs like levetiracetam, carbamazepine and phenytoin could affect treatment response in epilepsy especially in subjects with already altered body composition status like obese and thin frail patients, which needs to be established by prospective studies (CTRI/2013/05/003701)."3.83Comparison of body composition in persons with epilepsy on conventional & new antiepileptic drugs. ( Gupta, YK; Kakkar, AK; Sarangi, SC; Tripathi, M, 2016)
"Based on data from the EURAP observational International registry of antiepileptic drugs (AEDs) and pregnancy, we assessed changes in seizure control and subsequent AED changes in women who underwent attempts to withdraw valproic acid (VPA) during the first trimester of pregnancy."3.83Withdrawal of valproic acid treatment during pregnancy and seizure outcome: Observations from EURAP. ( Battino, D; Bonizzoni, E; Craig, J; Lindhout, D; Perucca, E; Sabers, A; Thomas, SV; Tomson, T; Vajda, F, 2016)
" Here, we suggest that triggering limbic seizures with low doses of PTZ in pilocarpine-treated marmosets might provide a more effective basis for the development of AED."3.83Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. ( Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM, 2016)
"The present study aimed to develop a neurochemistry-based single or adjuvant therapy approach for comprehensive management of epilepsy and associated depression employing pentylenetetrazole-kindled animals."3.83Evidence in support of using a neurochemistry approach to identify therapy for both epilepsy and associated depression. ( Goel, RK; Singh, T, 2016)
"The patients in Group I presented with adolescent-onset and related to photosensitive idiopathic generalized epilepsy (IGE), were responsive to valproic acid (VPA) or magnesium valproate (VPA-Mg) therapy, and presented a major seizure-precipitating factor in response to electronic games."3.83Clinical features of patients with game-induced seizures in the Chinese population. ( Chen, Y; Fu, Y; Huang, S; Liu, C; Long, H; Long, L; Xiao, B; Yang, X; Zhan, Q; Zhou, L; Zhou, P, 2016)
" Children exposed to monotherapy levetiracetam (n = 42), topiramate (n = 27), or valproate (n = 47) and a group of children born to women who had untreated epilepsy (n = 55) were enrolled retrospectively from the UK Epilepsy and Pregnancy Register."3.83Cognition in school-age children exposed to levetiracetam, topiramate, or sodium valproate. ( Baker, GA; Bromley, RL; Calderbank, R; Cheyne, CP; Clayton-Smith, J; García-Fiñana, M; Irwin, B; Morrow, JI; Rooney, C; Shallcross, R; Trayner, P, 2016)
"We compared persistence of antiepileptic drugs (AEDs) including carbamazepine, oxcarbazepine, gabapentin, lamotrigine, topiramate, valproic acid, and phenytoin in an Asian population with epilepsy."3.83Comparative persistence of antiepileptic drugs in patients with epilepsy: A STROBE-compliant retrospective cohort study. ( Hsieh, CY; Huang, CW; Lai, EC; Lin, SJ; Setoguchi, S; Su, CC; Yang, YK, 2016)
"Valproic acid (VPA) is a widely used antiepileptic drug with acceptable safety and efficacy in treating pediatric patients with various kinds of seizures."3.83Effects of UGT1A6 and GABRA1 on Standardized Valproic Acid Plasma Concentrations and Treatment Effect in Children With Epilepsy in China. ( Fang, F; Feng, W; Gao, B; Mei, S; Wu, X; Yang, W; Yu, Y; Zhao, Z; Zhu, L, 2016)
" This compound was effective in delaying onset of PTZ-evoked seizures at the dose of 5mg/kg in kindled animals and significantly reduced oxidative stress better than standard drug phenobarbital (PB)."3.81Design, synthesis and pharmacological evaluation of N-[4-(4-(alkyl/aryl/heteroaryl)-piperazin-1-yl)-phenyl]-carbamic acid ethyl ester derivatives as novel anticonvulsant agents. ( Kumari, S; Mishra, CB; Tiwari, M, 2015)
"Lamotrigine (LTG) is a widely used antiepileptic-drug (AED) for the treatment of epilepsy."3.81Effect of comedication on lamotrigine clearance in Korean epilepsy patients. ( Hong, SB; Joo, EY; Kim, HJ; Kim, TE; Lee, SY; Seo, DW, 2015)
"Pentylenetetrazol (PTZ)-induced chronic kindling model and lithium-pilocarpine-induced status epilepticus (SE) model were used in this study."3.81Degeneration and regeneration of GABAergic interneurons in the dentate gyrus of adult mice in experimental models of epilepsy. ( Jiang, W; Wang, Y; Wei, D; Wu, C; Wu, SX; Yang, F, 2015)
"Stiripentol is an antiepileptic drug (AED) approved by the European Medicines Agency for the treatment of Dravet Syndrome (DS) as adjunct treatment with valproate and clobazam."3.81Extending the use of stiripentol to other epileptic syndromes: a case of PCDH19-related epilepsy. ( Specchio, N; Trivisano, M; Vigevano, F, 2015)
"Carnitine deficiency is relatively common in epilepsy; risk factors reportedly include combination antiepileptic drug (AED) therapy with valproic acid (VPA), young age, intellectual disability, diet and enteral or parenteral feeding."3.81Carnitine deficiency: Risk factors and incidence in children with epilepsy. ( Fukuda, M; Ishii, E; Iwano, S; Kawabe, M; Kikuchi, C; Kuwabara, K; Morimoto, T; Suzuki, Y; Takehara, M; Wakamoto, H, 2015)
"This case suggests that rufinamide may induce the potentially serious adverse effect of agranulocytosis."3.81A granulocytosis associated with rufinamide: A case report. ( Awaya, T; Heike, T; Ide, M; Kato, T; Nakata, M; Saito, K; Yoshida, T, 2015)
"Weight gain is the most frequent adverse effect of valproic acid (VPA) treatment, resulting in poor compliance and many endocrine disturbances."3.81Association of LEPR and ANKK1 Gene Polymorphisms with Weight Gain in Epilepsy Patients Receiving Valproic Acid. ( Chen, X; Chen, Z; Hou, X; Huang, M; Li, H; Li, J; Ni, G; Su, Q; Wang, X; Xie, W; Xin, S; Zhou, L; Zhou, Y, 2015)
"To prospectively evaluate the long-term impact of valproate (VPA) versus carbamazepine (CBZ) on anthropometric, hormonal, and metabolic parameters in young male patients treated for epilepsy."3.81Endocrine Effects of Valproate versus Carbamazepine in Males with Epilepsy: A Prospective Study. ( de Vries, L; Goldberg-Stern, H; Itzhaki, T; Landau, Z, 2015)
" VPA and CBZ proved to be equally effective in Rett patients who presented seizures within the typical age range (4-5 years), while Lamotrigine (LTG) was effective for patients in whom epilepsy started later."3.81Antiepileptic drugs in Rett Syndrome. ( Baglietto, MG; Calevo, MG; Canevini, M; Giacomini, T; Giordano, L; Hayek, Y; Pintaudi, M; Renieri, A; Russo, S; Traverso, M; Veneselli, E; Vignoli, A, 2015)
"Valproic acid is often used in psychiatry to treat schizophrenia and other conditions outside of indication ("off-label")."3.81[Use of valproic acid in long stay units of psychiatry]. ( Chillerón-Cuenca, R; Esplá-González, S; Hernández-Pérez, P; Herraiz-Robles, P; Martínez-Lazcano, MT; Pol-Yanguas, E, 2015)
"In this cross-sectional study, 60 patients with epilepsy who were receiving valproate (VPA) (n = 30) or lamotrigine (LTG) (n = 30) monotherapy were enrolled."3.81Effects of antiepileptic drug monotherapy on one-carbon metabolism and DNA methylation in patients with epilepsy. ( Chen, Y; Chen, Z; Fang, Z; Huang, M; Li, H; Ni, G; Qin, J; Zhou, J; Zhou, L; Zhou, Y, 2015)
"Lamotrigine (LTG) is widely used in the treatment of children with epilepsy."3.81Effects of UGT1A4 genetic polymorphisms on serum lamotrigine concentrations in Chinese children with epilepsy. ( Dong, Y; Guo, Y; Liang, M; Qiu, F; Wang, Q; Yun, W; Zhao, L, 2015)
"The study was conducted on children aged 8-16 years who were undergoing valproic acid monotherapy for epilepsy."3.81An Evaluation of Peripapillary Retinal Nerve Fiber Layer Thickness in Children With Epilepsy Receiving Treatment of Valproic Acid. ( Akçam, M; Dereci, S; Koca, T; Türkyilmaz, K, 2015)
" We evaluated influence of DHA on anticonvulsant activity of AEDs phenytoin, valproate, and lamotrigine in maximal electroshock (MES), pentylenetetrazole (PTZ), and kindling models of epilepsy."3.81Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models. ( Babapour, V; Gavzan, H; Sardari, S; Sayyah, M, 2015)
"The aim of this study was to investigate the distribution and frequency of genetic polymorphisms in uridine diphosphate glucuronosyltransferase-2B7 (UGT2B7) in epilepsy patients and to evaluate the effect of these on the metabolism of valproic acid (VPA)."3.81The influence of UGT2B7 genotype on valproic acid pharmacokinetics in Chinese epilepsy patients. ( Huang, HW; Lin, H; Luo, YH; Peng, ZK; Sun, YX; Tang, FQ; Wang, HM; Zhuo, WY, 2015)
"Valproic acid (VPA) is a useful antiepileptic drug for controlling different types of epilepsy."3.81[The prevalence of obesity and metabolic syndrome in paediatric patients with epilepsy treated in monotherapy with valproic acid]. ( Carmona-Vazquez, CR; Diaz-Garcia, L; Greenawalt, SR; Pena-Landin, DM; Ruiz-Garcia, M, 2015)
"The purpose of the present study was to examine the relationship between the incidence of hyperammonemia and changes in the prescribing of concomitant antiepileptic drugs (AEDs) in patients receiving valproic acid."3.81Changing incidence of hyperammonemia in Japan from 2006 to 2013: expansion of new antiepileptic drugs reduces the risk of hyperammonemia. ( Imai, K; Inoue, Y; Kagawa, Y; Mishima, N; Takahashi, Y; Yamamoto, Y, 2015)
"To examine the effects of cytochrome P450 3A4 (CYP3A4), cytochrome P450 3A5 (CYP3A5) and ATP-binding cassette sub-family B member 1 (ABCB1) genetic polymorphisms on carbamazepine (CBZ) plasma concentrations in Chinese patients with epilepsy using CBZ as monotherapy and bitherapy with phenytoin (PHT), phenobarbital (PB), or valproic acid (VPA)."3.81Effects of CYP3A4/5 and ABCB1 genetic polymorphisms on carbamazepine metabolism and transport in Chinese patients with epilepsy treated with carbamazepine in monotherapy and bitherapy. ( Liu, DQ; Ma, HY; Sheng, YH; Wang, C; Wang, P; Yin, T; Zhou, BT, 2015)
"Valproic acid (VPA), which is widely used to treat epilepsy, migraine, and bipolar disorder, can causes severe hyperammonemia."3.81Influence of glutamine synthetase gene polymorphisms on the development of hyperammonemia during valproic acid-based therapy. ( Hirai, K; Imai, K; Inoue, K; Inoue, Y; Itoh, K; Suzuki, E; Takahashi, T; Takahashi, Y; Tsuji, D; Yamamoto, Y, 2015)
"Valproic acid (VPA) is widely used to treat various types of epilepsy."3.80Influence of uridine diphosphate glucuronosyltransferase 2B7 -161C>T polymorphism on the concentration of valproic acid in pediatric epilepsy patients. ( Hayashi, H; Imai, K; Inoue, K; Inoue, Y; Itoh, K; Koyama, S; Suzuki, E; Takahashi, T; Takahashi, Y; Tsuji, D; Yamamoto, Y; Yazawa, R, 2014)
"A 12-year-old patient with refractory epilepsy syndrome presented with phenytoin toxicity, following a concomitant treatment with phenytoin, valproic acid, and lamotrigine."3.80Drug interaction between phenytoin and valproic acid in a child with refractory epilepsy: a case report. ( Carnevale, RC; Carvalho, IV; de Fátima Lopes Ambrósio, R; de Queiroz, RA; dos Reis, MC; Mazzola, PG; Moriel, P; Visacri, MB, 2014)
"To compare the cognitive and language development of children born to women with epilepsy (WWE) exposed in utero to levetiracetam (LEV) or sodium valproate (VPA) and control children born to women without epilepsy not taking medication during pregnancy."3.80In utero exposure to levetiracetam vs valproate: development and language at 3 years of age. ( Baker, GA; Bromley, RL; Cheyne, CP; García-Fiñana, M; Irwin, B; Morrow, J; Shallcross, R, 2014)
" Therefore, this multicenter cross-sectional study aimed to evaluate the prevalence of reproductive endocrine dysfunctions in pubertal females with epilepsy receiving VPA, lamotrigine (LTG), or levetiracetam (LEV) monotherapy."3.80Reproductive endocrine health in pubertal females with epilepsy on antiepileptic drugs: time to screen? ( Agostinelli, S; Baumann, M; Haberlandt, E; Luef, G; Pizzolorusso, A; Prieschl, M; Rauchenzauner, M; Roscia, S; Rostasy, K; Verrotti, A; Wildt, L, 2014)
" Here we provide updated results from the UK Epilepsy and Pregnancy Register of the risk of MCMs after monotherapy exposure to valproate, carbamazepine and lamotrigine."3.80Malformation risks of antiepileptic drug monotherapies in pregnancy: updated results from the UK and Ireland Epilepsy and Pregnancy Registers. ( Campbell, E; Craig, J; Delanty, N; Hunt, SJ; Irwin, B; Kennedy, F; Liggan, B; Morrison, PJ; Morrow, J; Parsons, L; Russell, A; Smithson, WH, 2014)
"Lacosamide (LCM), a new antiepileptic drug (AED) approved as adjunctive therapy for the treatment of patients with partial-onset seizures, has limited pharmacokinetic and drug interaction data."3.80Lacosamide serum concentrations in adult patients with epilepsy: the influence of gender, age, dose, and concomitant antiepileptic drugs. ( Duncan, JS; Markoula, S; Patsalos, PN; Ratnaraj, N; Sander, JW; Teotonio, R, 2014)
"The aims of this study were to characterize a lamotrigine-resistant kindled model of epilepsy in mice, to study the anticonvulsant effect of carbamazepine (CBZ) and valproic acid (VPA), and to probe into the mechanism for resistance."3.80Characterization of a lamotrigine-resistant kindled model of epilepsy in mice: evaluation of drug resistance mechanisms. ( Mehndiratta, M; Pillai, KK; Singh, E, 2014)
"Valproic acid, a branched short-chain fatty acid, has numerous action mechanisms which turn it into a broad spectrum anticonvulsant drug and make its use possible in some other pathologies such as bipolar disorder."3.80Hyperammonemia associated with valproic acid concentrations. ( Alvariza, S; Fagiolino, P; Guevara, N; Ibarra, M; Magallanes, L; Maldonado, C; Olano, I; Olmos, I; Vázquez, M, 2014)
"Valproic acid, which is widely used to treat various types of epilepsy, may cause severe hyperammonemia."3.804217C>A polymorphism in carbamoyl-phosphate synthase 1 gene may not associate with hyperammonemia development during valproic acid-based therapy. ( Hayashi, H; Imai, K; Inoue, K; Inoue, Y; Itoh, K; Miyakawa, K; Suzuki, E; Takahashi, T; Takahashi, Y; Tsuji, D; Yamamoto, Y; Yazawa, R, 2014)
"To investigate biochemical cardiovascular risk factors and vascular endothelial function and structure in children with epilepsy on antiepileptic drugs (AEDs), particularly sodium valproate (VPA) and carbamazepine (CBZ)."3.80Vascular function and risk factors in children with epilepsy: associations with sodium valproate and carbamazepine. ( Keenan, N; Sadlier, LG; Wiltshire, E, 2014)
"Evidence from this and other studies suggests that lamotrigine and levetiracetam have low risk for teratogenesis, but that topiramate exposure early in pregnancy may be associated with dose-related anatomical teratogenesis, as valproate is already known to be."3.80The teratogenicity of the newer antiepileptic drugs - an update. ( Eadie, MJ; Graham, J; Lander, CM; O'Brien, TJ; Vajda, FJ, 2014)
"Hyperammonemia has been reported to be associated with patients who receive valproic acid (VPA) therapy."3.80Risk factors of hyperammonemia in patients with epilepsy under valproic acid therapy. ( Chang, CC; Chang, WN; Chen, NC; Chuang, YC; Huang, CR; Lin, CH; Lu, CH; Lu, YT; Tseng, YL, 2014)
"To facilitate therapeutic monitoring of antiepileptic drugs (AEDs) by healthcare professionals for patients with epilepsy (PWE), we applied a GC-MS assay to measure three AEDs: carbamazepine (CBZ), phenytoin (PHT) and valproic acid (VPA) levels concurrently in one dried blood spot (DBS), and validated the DBS-measured levels to their plasma levels."3.80Clinical validation and implications of dried blood spot sampling of carbamazepine, valproic acid and phenytoin in patients with epilepsy. ( Ho, PC; Kong, ST; Kumar, PK; Lee, WB; Lim, SH; Ng, YL; Wang, HY; Wong, PS, 2014)
"A 54-year-old woman with known epilepsy developed convulsions after using rifampicin and flucloxacillin, despite the use of maintenance treatment in the form of carbamazepine, valproic acid and clonazepam."3.80[Convulsions due to an interaction between anti-epileptic drugs and rifampicin]. ( Hanrath, MA; Swart, EL, 2014)
"The combination of lamotrigine and valproate/divalproex sodium has been shown to be effective in the treatment of refractory epilepsy."3.79Valproate and lamotrigine in pediatric patients with refractory epilepsy: after the first year. ( Thome-Souza, S; Valente, KD, 2013)
"Our findings suggest that the UGT1A6 (552A>C) genetic polymorphism plays a significant role in the steady state concentration of valproic acid, and it thereby has an impact on the toxicity of the valproic acid used in the patients with epilepsy."3.79The effect of uridine diphosphate glucuronosyltransferase (UGT)1A6 genetic polymorphism on valproic acid pharmacokinetics in Indian patients with epilepsy: a pharmacogenetic approach. ( Arumugam, K; Behari, M; Jain, DC; Mallayasamy, SR; Munisamy, M; Raghavan, S; Rajakannan, T; Ramanujam, B; Subbiah, V; Tripathi, M, 2013)
" Ten patients on valproic acid therapy of any age group with idiopathic or secondary epilepsy, who presented with encephalopathic symptoms, were registered and followed up during the study."3.79Valproic acid induced hyperammonaemic encephalopathy. ( Amanat, S; Hassan, Y; Shahbaz, N, 2013)
" We investigated the effects of valproic acid and topiramate on the levels of insulin, c-peptide and adipocytokines in pre-pubertal patients with idiopathic partial and generalized epilepsy."3.79The effects of topiramate and valproate therapy on insulin, c-peptide, leptin, neuropeptide Y, adiponectin, visfatin, and resistin levels in children with epilepsy. ( Aksoy, A; Aliyazicioglu, R; Deger, O; Fazlioglu, K; Karaguzel, G; Sonmez, FM; Zaman, D, 2013)
"The effects of the antiepileptic drugs sodium valproate (VPA) and levetiracetam (LEV) on reproductive endocrine function, sexual function, and spermatozoa were explored, together with their possible etiological mechanisms, in Chinese Han men with epilepsy."3.79Effects of antiepileptic drugs on reproductive endocrine function, sexual function and sperm parameters in Chinese Han men with epilepsy. ( Daoliang, X; Hengzhong, Z; Xiaotian, X; Yao, X; Yumei, W; Zhipan, Z, 2013)
" We describe the effects of focally applied valproate (VPA) in a newly emerging rat model of neocortical epilepsy induced by tetanus toxin (TeT) plus cobalt chloride (CoCl₂)."3.79Locally applied valproate enhances survival in rats after neocortical treatment with tetanus toxin and cobalt chloride. ( Altenmüller, DM; Feuerstein, TJ; Freiman, TM; Hebel, JM; Rassner, MP; Volz, S; Zentner, J, 2013)
" (MQ) in maximal electroshock (MES) and pentylenetetrazole (PTZ) induced rat models of epilepsy."3.79Evaluation of anti-epileptic property of Marsilea quadrifolia Linn. in maximal electroshock and pentylenetetrazole-induced rat models of epilepsy. ( Avinash, H; Chandrashekar, BR; Mukunda, N; Naduvil Narayanan, S; Nayak, BS; Raghavendra Rao, K; Sadhana, N; Satish Kumar, MC; Snehunsu, A; Vijay Kapgal, K, 2013)
"We studied 107 patients with epilepsy who received monotherapy with valproic acid drugs (58) and carbamazepine (49)."3.79[Season fluctuations of carbamazepine and valproate concentration in patients with epilepsy]. ( Avakian, GG; Avakian, GN; Bogomazova, MA; Delger, AB; Khromykh, EA; Lagutin, IuV; Oleĭnikova, OM, 2013)
"The participants included 53 epilepsy patients who received either valproic acid (VPA, n=26) or oxcarbazepine (OXC, n=27)."3.79Assessment of atherosclerosis risk due to the homocysteine-asymmetric dimethylarginine-nitric oxide cascade in children taking antiepileptic drugs. ( Arga, M; Arhan, E; Biberoglu, G; Cansu, A; Emeksiz, HC; Gulbahar, O; Hasanoglu, A; Serdaroglu, A, 2013)
"Valproic acid (VPA) is the most widely prescribed epilepsy treatment worldwide, but its mechanism of action remains unclear."3.78The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium. ( Bialer, M; Chang, P; Deranieh, RM; Dham, M; Greenberg, ML; Hoeller, O; Orabi, B; Shimshoni, JA; Walker, MC; Williams, RS; Yagen, B, 2012)
"Valproic acid (VPA) is a well-established anticonvulsant drug that has been increasingly used in the treatment of many forms of generalized epilepsy."3.78Simultaneous determination of valproic acid and 2-propyl-4-pentenoic acid for the prediction of clinical adverse effects in Chinese patients with epilepsy. ( Chen, SD; Chen, ZJ; Fang, ZY; Huang, M; Li, JL; Shu, WY; Wang, HS; Wang, XD; Zhang, Y; Zhou, JQ; Zhou, LM, 2012)
"The association between the superoxide dismutase 2 (SOD2) Val16Ala polymorphism and the serum aminotransferase levels was retrospectively investigated in 207 valproic acid-treated patients with epilepsy."3.78Superoxide dismutase 2 Val16Ala polymorphism is a risk factor for the valproic acid-related elevation of serum aminotransferases. ( Deguchi, M; Ishitsu, T; Kaneko, S; Nakagawa, K; Noai, M; Ogusu, N; Oniki, K; Saruwatari, J; Yasui-Furukori, N; Yoshida, S; Yoshimori, Y, 2012)
"The aim of this study was to investigate the genetic polymorphisms of UGT1A3, UGT1A6, and UGT2B7 in Chinese epilepsy patients and their potential influence on the pharmacokinetics of valproic acid (VPA)."3.78Influence of UDP-glucuronosyltransferase polymorphisms on valproic acid pharmacokinetics in Chinese epilepsy patients. ( Chu, XM; Hao, HP; Wang, GJ; Zhang, LF; Zhang, SN; Zhou, JH, 2012)
"We recruited 98 patients with epilepsy (45 taking phenytoin, 27 taking valproate, and 26 not taking any AED)."3.78Characterization of glucose homeostasis and lipid profile in adult, seizure-free, epileptic patients in Asian population. ( Geater, A; Limapichat, K; Phabphal, K; Sathirapanya, P; Setthawatcharawanich, S, 2012)
"Based on epidemiological data it is advised to whenever possible avoid valproic acid during pregnancy."3.78Economic evaluation of anti-epileptic drug therapies with specific focus on teratogenic outcomes. ( Boersma, C; de Jong-van den Berg, LT; Jentink, J; Postma, MJ, 2012)
"Hyperammonemia is one of the side effects of treatment with valproic acid (VPA), but the risk factors and mechanisms involved remain obscure."3.78Risk factors for hyperammonemia associated with valproic acid therapy in adult epilepsy patients. ( Inoue, K; Inoue, Y; Itoh, K; Kagawa, Y; Mishima, N; Suzuki, E; Takahashi, Y; Yamamoto, Y, 2012)
"The aim of this study was to evaluate the incidence of thyroid dysfunction during valproic acid (VPA) therapy in children and adolescents with epilepsy."3.78Subclinical hypothyroidism during valproic acid therapy in children and adolescents with epilepsy. ( Chae, JH; Chung, HR; Hwang, H; Hwang, YS; Kim, H; Kim, KJ; Kim, SH; Lim, BC, 2012)
" The aim of the present study was to evaluate plasma insulin, leptin, neuropeptide Y (NPY), ghrelin, and adiponectin levels in children with epilepsy treated with VPA and to evaluate these parameters for early atherosclerosis."3.78Plasma leptin, neuropeptide Y, ghrelin, and adiponectin levels and carotid artery intima media thickness in epileptic children treated with valproate. ( Aydin, K; Kiyici, A; Oran, B; Tokgoz, H, 2012)
"We report 2 children with a history of epilepsy in whom valproic acid (VPA) withdrawal was identified as a potential cause of hallucinations."3.78Hallucinations after withdrawal of valproic acid. ( Braun, KP; de Graeff-Meeder, ER; de Laat, SA; Hillegers, MH; Jansen, FE, 2012)
" We conducted a pilot study to assess the feasibility, efficacy and side-effects of VPA in the treatment of convulsive epilepsy in primary care settings in rural China as an alternative to phenobarbital."3.78Sodium valproate for epilepsy in rural China: an efficacy and safety assessment in primary care. ( Li, S; Ru, X; Sander, JW; Wang, W; Wu, J; Zheng, J; Zhu, S, 2012)
"We examined the influence of age and type of concomitant antiepileptic drugs (AEDs) on the pharmacokinetics of rufinamide (RUF) as well as its efficacy and safety in 51 children with refractory epilepsy."3.78Rufinamide in children with refractory epilepsy: pharmacokinetics, efficacy, and safety. ( Dahlin, MG; Ohman, I, 2012)
"Valproic acid (VPA) is one of the most commonly prescribed drugs for the treatment of epilepsy."3.78Effects of UGT1A6, UGT2B7, and CYP2C9 genotypes on plasma concentrations of valproic acid in Chinese children with epilepsy. ( Guo, Y; He, X; Hu, C; Qiu, F; Zhao, L, 2012)
"An open pilot study to evaluate the effect of pregabalin (PGB) as add-on therapy on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy (BTRE)."3.78Effect of pregabalin add-on treatment on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy: a pilot study. ( Carapella, CM; Dinapoli, L; Fabi, A; Maschio, M; Pace, A; Pompili, A; Sperati, F; Vidiri, A, 2012)
"Children with refractory epilepsy who suffered from severe liver function impairment during valproic acid (VPA) treatment at routine dosage were studied."3.78[Valproic acid-induced idiosyncratic liver injury in 4 cases]. ( Bao, XH; Jiang, YW; Liu, CT; Qin, J; Wu, XP; Xiong, H; Zhang, YH; Zhao, H, 2012)
"Weight gain is a well-known unwanted effect of valproic acid (VPA) therapy."3.77Circulating levels of allopregnanolone, a neuroactive steroid, and leptin during treatment with valproic acid in children with epilepsy. ( Balestri, P; Barlocco, EG; Casarosa, E; Grosso, S; Luisi, S; Matera, M; Mostardini, R; Petraglia, F, 2011)
"Many investigators agree that appropriate rational utilization of therapeutic drug monitoring (TDM) with Bayesian feedback dosage adjustment facilitates epilepsy treatment with carbamazepine (CBZ) and/or valproate (VPA) by increasing the seizure control and safety, as well as by reducing treatment costs."3.77Predictability of individualized dosage regimens of carbamazepine and valproate mono- and combination therapy. ( Andreeva, OV; Bondareva, IB; Bondareva, KI; Jelliffe, RW, 2011)
"Patients treated with valproic acid (VPA) present a high incidence of non-alcoholic fatty liver disease (NAFLD) (around 61%)."3.77A preliminary investigation on the possible association between diminished copper availability and non-alcoholic fatty liver disease in epileptic patients treated with valproic acid. ( Lampon, N; Tutor, JC, 2011)
"Pre-morning-dose serum valproic acid concentrations were measured in 76 subjects with epilepsy (48 M, 28 F, age range 6-20 years, mean age 14 years) in whom lamotrigine was added while the dose of valproate and other medication remained unchanged."3.77The effect of lamotrigine on valproic acid concentrations. ( Berry, DJ; Besag, FM; Besag, FP; Martin, AC, 2011)
"Valproic acid monotherapy is associated with NAFLD in a high percentage of adolescents with epilepsy who have typical VPA-related metabolic disturbances."3.77Nonalcoholic fatty liver disease in adolescents receiving valproic acid. ( Agostinelli, S; Chiarelli, F; Coppola, G; Parisi, P; Verrotti, A, 2011)
"Children born to women with epilepsy (WWE), exposed in utero to levetiracetam (LEV, n = 51), were assessed for early cognitive development and compared to children exposed to sodium valproate in utero (VPA, n = 44) and a group of children representative of the general population (n = 97)."3.77Child development following in utero exposure: levetiracetam vs sodium valproate. ( Baker, GA; Bonnett, LJ; Bromley, RL; Irwin, B; Morrow, J; Shallcross, R, 2011)
"Extractive electrospray ionization mass spectrometry is shown to allow real-time, in vivo drug monitoring and pharmacokinetic measurement in a non-invasive, pain-free manner as demonstrated by the mass spectral measurement of a novel exhaled breath biomarker for valproic acid, a medication used to control epilepsy."3.77Real-time, in vivo monitoring and pharmacokinetics of valproic acid via a novel biomarker in exhaled breath. ( Azov, V; Chen, H; Chingin, K; Disko, A; Gamez, G; Krämer, G; Zenobi, R; Zhu, L, 2011)
"This study aims to investigate the alteration of iron homeostasis and oxidative stress status in epilepsy patients treated with valproic acid (VPA) monotherapy."3.77Increase in non-transferrin bound iron and the oxidative stress status in epilepsy patients treated using valproic acid monotherapy. ( Atroshi, F; Fucharoen, S; Kaipainen, P; Kaski, M; Ounjaijean, S; Partinen, M; Plonka-Poltorak, E; Srichairatanakool, S; Westermarck, T, 2011)
"Lamotrigine (LTG) which has a widespread use in epilepsy treatment as an antiepileptic agent is metabolized by UDP-glucuronosyl transferase (UGT) enzymes."3.77The relationship between UGT1A4 polymorphism and serum concentration of lamotrigine in patients with epilepsy. ( Aker, RG; Goren, MZ; Gulcebi, MI; Onat, FY; Ozkara, C; Ozkaynakcı, A, 2011)
"The aim of this study was to establish the population protein binding parameters of valproic acid (VPA) in patients with epilepsy receiving VPA monotherapy and those receiving VPA combined with other antiepileptic drugs."3.77No effect of co-administered antiepileptic drugs on in-vivo protein binding parameters of valproic acid in patients with epilepsy. ( Abe, T; Itoh, H; Nishimura, F; Sato, Y; Suzuki, Y; Takeyama, M, 2011)
"Increased serum levels of leptin, NPY and galanin play an important role in VPA-associated weight gain in children."3.77Serum insulin, cortisol, leptin, neuropeptide Y, galanin and ghrelin levels in epileptic children receiving valproate. ( Camurdan, O; Cansu, A; Cinaz, P; Hırfanoğlu, T; Serdaroglu, A, 2011)
"Our study underscores the importance of considering drugs as a cause and a contributor to pancreatitis in children, particularly valproic acid in young children."3.77Novel characterization of drug-associated pancreatitis in children. ( Bai, HX; Bhandari, V; Husain, SZ; Latif, SU; Ma, MH; Orabi, AI; Park, A, 2011)
"A retrospective cohort study using a large health insurance plan claims database comparing patients with epilepsy who switched from brand to generic equivalent phenytoin, lamotrigine, or divalproex after 6 months (switch cohorts) to matched patients who remained on the brand (nonswitch cohorts)."3.77Clinical and pharmacy utilization outcomes with brand to generic antiepileptic switches in patients with epilepsy. ( Curtis, B; Erickson, SC; Harada, AS; Le, L; Ramsey, SD; Solow, BK; Stockl, KM; Zakharyan, A, 2011)
"Valproic acid, which current guidelines suggest should be avoided in pregnancy, was most notable in terms of strength and breadth of its associations."3.77Use of antiepileptic medications in pregnancy in relation to risks of birth defects. ( Ahrens, KA; Anderka, MT; Bosco, JL; Gilboa, SM; Holmes, LB; Mitchell, AA; Werler, MM, 2011)
"Our study was carried out to ascertain the role of valproic acid for inducing metabolic disorders like hyperinsulinemia, insulin resistance and metabolic syndrome."3.77Fasting insulin and HOMA-index changes in patients treated with valproic acid. ( Javashvili, L; Kasradze, S; Mania, M; Okujava, N, 2011)
"We investigated the effect of lamotrigine (LTG) add-on therapy in 50 patients with childhood-onset refractory epilepsy (25 males and 25 females): 15 with localization-related epilepsy, 33 with generalized epilepsy, and 2 with undetermined epilepsy."3.77[Lamotrigine add-on therapy for childhood-onset refractory epilepsy: comparison of the efficacy between 3 months and 6 months after initiation]. ( Endoh, F; Kobayashi, K; Ohtsuka, Y; Watanabe, K; Yoshinaga, H, 2011)
"This prospective study was designed to investigate whether or not monotherapy with sodium valproate (VPA) or oxcarbazepine (OXC) affects plasma levels of fatty acylcarnitine esters in children with epilepsy."3.77Analysis of acylcarnitine levels by tandem mass spectrometry in epileptic children receiving valproate and oxcarbazepine. ( Biberoglu, G; Cansu, A; Ezgu, FS; Hasanoglu, A; Hirfanoglu, TL; Serdaroglu, A; Tumer, L, 2011)
" We previously showed that tolerance to levetiracetam (LEV) developed within 4 days after the start of the treatment in a rat model for spontaneous seizures after electrically induced status epilepticus."3.76Improved seizure control by alternating therapy of levetiracetam and valproate in epileptic rats. ( Edelbroek, PM; Gorter, JA; van Vliet, EA, 2010)
"Valproic acid (VPA) is widely used clinically in epilepsy, bipolar disorder, and migraine."3.76Inhibition of long-term potentiation by valproic acid through modulation of cyclic AMP. ( Chandler, KE; Chang, P; Walker, MC; Williams, RS, 2010)
"Young adult outpatients with epilepsy on monotherapy for no less than 6 months with carbamazepine (CBZ), valproic acid (VPA), oxcarbazepine (OXC) and topiramate (TPM) were examined."3.76Effects of the antiepileptic drugs on peripheral nerve function. ( Boylu, E; Domaç, FM; Misirli, H; Saraçoğlu, M; Senol, MG, 2010)
"Levetiracetam (LEV, 2S-(oxo-1-pyrrolidinyl)butanamide, Keppra, UCB Pharma) is a new anti-epileptic drug used to treat certain types of seizures in epilepsy patients."3.76Levetiracetam inhibits interleukin-1 beta inflammatory responses in the hippocampus and piriform cortex of epileptic rats. ( Choi, HC; Choi, SY; Jo, SM; Kang, TC; Kim, DS; Kim, JE; Kim, YI; Song, HK, 2010)
"Valproic acid (VPA) has been used for epilepsy treatment since the 1970s."3.76Valproic acid in the complex therapy of malignant tumors. ( Eckschlager, T; Hrabeta, J; Hrebackova, J, 2010)
"The study comprised 40 children and adolescents with idiopathic epilepsy on either valproate or carbamazepine."3.76Growth hormone levels in children and adolescents with epilepsy. ( Al-Badani, AK; Aly, GS; El-Khayat, HA; Mamdouh, RM; Mohamed, EI; Tomoum, HY, 2010)
"Two severely disabled children with epilepsy, a 6-year-old boy and a 15-year-old girl, had been treated with valproic acid from the ages of 5 and 6 months, respectively, and developed Fanconi syndrome."3.76Fanconi syndrome caused by valproic acid. ( Endo, A; Fuchigami, T; Fujita, Y; Mugishima, H; Takahashi, S, 2010)
"In order to clarify the factors causing hyperammonemia and to predict occurrences during treatment with valproic acid (VPA), we investigated the effect of the genetic polymorphism of carbamoyl-phosphate synthase 1 (CPS14217C>A) on susceptibility of hyperammonemia, together with the effect of coadministration of other anticonvulsants."3.76Effect of CPS14217C>A genotype on valproic-acid-induced hyperammonemia. ( Kawasaki, Y; Matsuo, M; Nakamura, T; Okamura, N; Okizuka, Y; Okumura, K; Oyazato, Y; Sakaeda, T; Tsuneishi, S; Yagi, M, 2010)
" Patients with clinically stable partial or generalized epilepsy, already receiving lamotrigine or valproic acid on monotherapy, were assessed in two visits: baseline and at 6 months."3.76Quality of life and treatment satisfaction in Spanish epilepsy patients on monotherapy with lamotrigine or valproic acid. ( Barriga, J; Cobaleda, S; Codina, M; Lahuerta, J; Morales, MD; Viteri, C, 2010)
"Lamotrigine (LTG) is increasingly being prescribed in pregnancy for women with epilepsy in place of valproate (VPA), because of the teratogenic risks associated with the latter."3.76Is lamotrigine a significant human teratogen? Observations from the Australian Pregnancy Register. ( Eadie, MJ; Graham, JE; Hitchcock, AA; Lander, CM; O'Brien, TJ; Vajda, FJ, 2010)
" The influence of age and concomitant medications on the dose/concentration ratio of levetiracetam was examined in 103 children with epilepsy."3.76Age and comedications influence levetiracetam pharmacokinetics in children. ( Dahlin, MG; Ohman, I; Wide, K, 2010)
" Between 1999 and 2004, we enrolled pregnant women with epilepsy who were taking a single AED (carbamazepine, lamotrigine, phenytoin, or valproate)."3.76Effects of breastfeeding in children of women taking antiepileptic drugs. ( Baker, GA; Browning, N; Clayton-Smith, J; Cohen, M; Combs-Cantrell, DT; Kalayjian, LA; Kanner, A; Liporace, JD; Loring, DW; Meador, KJ; Pennell, PB; Privitera, M, 2010)
" In utero, exposure to valproic acid (VPA) and phenytoin (PH) may cause congenital malformations and also withdrawal symptoms such as irritability, jitteriness and symptoms of hypoglycemia."3.76Neonatal episodic hypoglycemia: a finding of valproic acid withdrawal. ( Akçakuş, M; Akın, MA; Çoban, D; Güneş, T; Kurtoğlu, S, 2010)
"We evaluated the serum leptin and insulin as predictors of weight gain in children receiving long-term treatment with valproate (VPA), carbamazepine (CBZ), lamotrigine (LTG)."3.75States of serum leptin and insulin in children with epilepsy: risk predictors of weight gain. ( Fida, NM; Hamed, EA; Hamed, SA, 2009)
"Valproic acid-associated weight gain may occur in young children."3.75Body mass index and serum lipid changes during treatment with valproic acid in children with epilepsy. ( Balestri, P; Grosso, S; Mostardini, R; Piccini, B, 2009)
"There are few reports on valproic acid related to thrombophilia."3.75Thrombophilic risk factors in epileptic children treated with valproic Acid. ( Akar, N; Deda, G; Ertem, M; Teber, S; Unal, O, 2009)
"Valproic acid (VPA) is effective for the treatment of many types of epilepsy, but its use can be associated with an increase in body weight."3.75Nonalcoholic fatty liver disease during valproate therapy. ( Chiarelli, F; Di Marco, G; la Torre, R; Pelliccia, P; Verrotti, A, 2009)
"The long-term effects of valproic acid (VPA) on reproductive endocrine functions in women with epilepsy (WWE) were studied."3.75Long-term effects of valproic acid on reproductive endocrine functions in Turkish women with epilepsy. ( Dogan, EA; Genc, BO; Genc, E; Gorkemli, H; Ozdemir, S, 2009)
"The aim of this study is to evaluate the erythrocyte lipid peroxidation and antioxidant enzyme levels in patients with newly diagnosed idiopathic epilepsy before treatment and in patients treated with valproic acid for idiopathic epilepsy."3.75Effects of epilepsy and valproic acid on oxidant status in children with idiopathic epilepsy. ( Dirik, E; Kuralay, F; Kurul, SH; Seçkin, E; Yiş, U, 2009)
"Between 1999 and 2004, we enrolled pregnant women with epilepsy who were taking a single antiepileptic agent (carbamazepine, lamotrigine, phenytoin, or valproate) in a prospective, observational, multicenter study in the United States and the United Kingdom."3.75Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs. ( Baker, GA; Browning, N; Clayton-Smith, J; Cohen, M; Combs-Cantrell, DT; Kalayjian, LA; Kanner, A; Liporace, JD; Loring, DW; Meador, KJ; Pennell, PB; Privitera, M, 2009)
" We point out that during the pregnancy 4 of these 5 women with epilepsy had taken valproates, and the other one--carbamazepine."3.75[Fetal malformations in women with epilepsy]. ( Bozhinov, P; Bozhinova, C; Markova, C, 2009)
"This substudy of the Neurodevelopmental Effects of Antiepileptic Drugs investigation enrolled pregnant women with epilepsy on AED monotherapy (carbamazepine, lamotrigine, and valproate)."3.75A prospective study of cognitive fluency and originality in children exposed in utero to carbamazepine, lamotrigine, or valproate monotherapy. ( Gaillard, WD; McVearry, KM; Meador, KJ; VanMeter, J, 2009)
"(1) Numerous follow-up studies of pregnancies in women with epilepsy show that valproic acid is more teratogenic than other antiepileptics."3.75Valproic acid: long-term effects on children exposed in utero. ( , 2009)
" Hyperhomocysteinemia was defined as fasting total Hcy above 12 micromol/L and/or post-methionine load concentrations above 38 micromol/L."3.74Drug-induced pertubation of the aminothiol redox-status in patients with epilepsy: improvement by B-vitamins. ( Apeland, T; Frøyland, ES; Kristensen, O; Mansoor, MA; Strandjord, RE, 2008)
"Although valproic acid (VPA) is used extensively for treating various kinds of epilepsy, it causes hepatotoxicity and teratogenicity."3.74Tetramethylcyclopropyl analogue of the leading antiepileptic drug, valproic acid: evaluation of the teratogenic effects of its amide derivatives in NMRI mice. ( Bialer, M; Fujiwara, M; Kaufmann, D; Okada, A; Onishi, Y; Shimshoni, JA; Yagen, B, 2008)
" In 5 pediatric patients with severe myoclonic epilepsy and valproic acid-induced liver failure, we identified 1 novel and 4 previously described pathogenic mutations in the linker region of this enzyme."3.74Clonally expanded mitochondrial DNA mutations in epileptic individuals with mutated DNA polymerase gamma. ( Baron, M; Bös, M; Chinnery, PF; Elger, CE; Kornblum, C; Kunz, WS; Sassen, R; Stewart, JD; Taylor, RW; Zsurka, G, 2008)
" This retrospective study of children with epilepsy, aged <12 years at enrollment, examined weight gain associated with valproic acid or carbamazepine monotherapy."3.74Lack of valproic acid-associated weight gain in prepubertal children. ( Baumann, RJ; Espinosa, PS; Mendiondo, MS; Robertson, WC; Salazar, JC; Yu, L, 2008)
"Folic acid supplementation reduces the occurrence of neural tube defects (NTDs); however, it is not clear whether it protects against teratogenic effects of antiepileptic drugs."3.74Plasma vitamin values and antiepileptic therapy: case reports of pregnancy outcomes affected by a neural tube defect. ( Boisson, C; Candito, M; Gaucherand, P; Guéant, JL; Luton, D; Naimi, M; Rudigoz, JC; Van Obberghen, E, 2007)
"Five oral formulations of valproic acid (VPA)/divalproex sodium are approved and commonly used in the US for treatment of epilepsy, mania/bipolar disorder and migraine prophylaxis."3.74Distinct absorption characteristics of oral formulations of valproic acid/divalproex available in the United States. ( Dutta, S; Reed, RC, 2007)
"To compare the incidence and magnitude of weight gain associated with valproic acid (VPA) monotherapy in male and female epilepsy patients and to determine possible gender-specific differences in frequency of carbohydrate craving, body-composition, glucose homeostasis and lipid metabolism."3.74Valproate, weight gain and carbohydrate craving: a gender study. ( Bauer, G; El-Khatib, F; Hoppichler, F; Lechleitner, M; Luef, GJ; Naser, A; Rauchenzauner, M; Trinka, E; Unterberger, I; Waldmann, M, 2007)
"To determine the influence of valproate (VPA) treatment on acylcarnitines in children with epilepsy."3.74Effects of valproate on acylcarnitines in children with epilepsy using ESI-MS/MS. ( Gerstner, T; Koenig, SA; Kohlmueller, D; Longin, E; Mehlem, P; Schulze, A; Teich, M; Treiss, I; Werner, T, 2007)
"To search for association between the 163G>A polymorphism of the fatty acid binding protein 2 (FABP2) gene and intracellular transport of the valproic acid in the small intestines, 168 patients with different forms of epilepsy, aged from 1 to 89 years, and different illness duration have been studied."3.74[An association between the FABP2 gene polymorphism and efficacy of valproates]. ( Aksenova, MG; Avakian, GN; Badalian, OL; Belousova, ED; Burd, SG; Dorofeeva, MIu; Gusev, EI; Kachalin, EIu; Savenkov, AA; Tertyshnik, OIu, 2007)
"Ecto-nucleotidases, one of the main mechanisms involved in the control of adenosine levels in the synaptic cleft, have shown increased activities after the pilocarpine model of epilepsy."3.74Antiepileptic drugs prevent changes induced by pilocarpine model of epilepsy in brain ecto-nucleotidases. ( Bogo, MR; Bonan, CD; Bruno, AN; Cognato, Gde P; da Silva, RS; Sarkis, JJ, 2007)
"Using the mouse maximal electroshock-induced seizure model, indicative of tonic-clonic seizures in humans, the present study was aimed at characterizing the interaction between remacemide and valproate, carbamazepine, phenytoin, and phenobarbital."3.74Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshock. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ; Malek, R; Patsalos, PN; Ratnaraj, N, 2007)
"Chronic antiepileptic therapy with valproic acid (VPA) is associated with increased body weight and insulin resistance in adults and children."3.74Adiponectin and visfatin concentrations in children treated with valproic acid. ( Ebenbichler, CF; Ernst, B; Haberlandt, E; Hoppichler, F; Karall, D; Luef, G; Rauchenzauner, M; Rostasy, K; Scholl-Bürgi, S, 2008)
"Valproic acid (VPA) is a commonly prescribed anticonvulsant drug for the treatment of various forms of epilepsy."3.74[Seven cases of decreased serum valproic acid concentration during concomitant use of carbapenem antibiotics]. ( Joo, JY; Kim, JH; Kwon, OH; Lee, SG, 2007)
" A total of 25 children with idiopathic epilepsy (8 valproate, 11 carbamazepine, and 6 oxcarbazepine) and 10 healthy children were included in the study."3.74Homocysteine levels in epileptic children receiving antiepileptic drugs. ( Kurul, S; Unalp, A; Yiş, U, 2007)
" We previously reported biochemical evidence of increased bone turnover in premenopausal women with epilepsy on phenytoin monotherapy compared with those on carbamazepine, lamotrigine, and valproate."3.74Bone health in young women with epilepsy after one year of antiepileptic drug monotherapy. ( McMahon, DJ; Morrell, MJ; Pack, AM; Randall, A; Shane, E, 2008)
"Therapeutic efficacy of valparin xr, a new form of valproic acid (VPA) generic drugs, manufactured by "Torrent Pharmaceuticals Ltd", India, has been studied in 25 patients with epilepsy of different types and frequency of seizures."3.74[The use of generic valparin xr in the treatment of epilepsy.]. ( Gromov, SA; Lipatova, LV, 2007)
"Hypospadias is one of the most frequently occurring genital anomalies described in infants prenatally exposed to valproic acid (VA)."3.74Risk of hypospadias in newborn infants exposed to valproic acid during the first trimester of pregnancy: a case-control study in Spain. ( Fernández, P; Martínez-Frías, ML; Mejías, C; Prieto-Merino, D; Rodríguez-Pinilla, E, 2008)
"The aim of our study was to investigate whether a correlation exists between steady-state serum concentration of valproic acid and quality of life in adolescent patients with epilepsy."3.74Inverse correlation of valproic acid serum concentrations and quality of life in adolescents with epilepsy. ( Jakovljevic, MB; Jankovic, SM; Jankovic, SV; Todorovic, N, 2008)
" The combination of AGLD (5 mg/kg) with phenobarbital (PB, applied at its subeffective dose of 15 mg/kg) significantly shortened motor seizure and afterdischarge duration in amygdala-kindled seizures."3.73Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats. ( Borowicz, KK; Czuczwar, SJ, 2005)
" We studied premenopausal women with epilepsy receiving antiepileptic drug monotherapy (phenytoin, carbamazepine, valproate, and lamotrigine)."3.73Bone mass and turnover in women with epilepsy on antiepileptic drug monotherapy. ( Doñe, S; Flaster, E; Holloway, L; Marcus, R; Morrell, MJ; Pack, AM; Randall, A; Seale, C; Shane, E, 2005)
"To report a probable interaction between meropenem and valproic acid that resulted in the development of epileptic seizures."3.73Acute seizures due to a probable interaction between valproic acid and meropenem. ( Borrás-Blasco, J; Coves-Orts, FJ; Murcia-López, A; Navarro-Ruiz, A; Palacios-Ortega, F, 2005)
"To determine the rate of occurrence of major malformations in infants whose mothers had taken the drug valproic acid (VPA) as monotherapy during the first trimester of pregnancy and had enrolled in the North American Antiepileptic Drug Pregnancy Registry."3.73Increased rate of major malformations in offspring exposed to valproate during pregnancy. ( Alsdorf, RM; Holmes, LB; Nambisan, M; Smith, CR; Surve, T; Wyszynski, DF, 2005)
" Serum interleukin-5 levels were measured with enzyme-linked immunosorbent assay technique in 68 children with epilepsy receiving sodium valproate monotherapy and compared with the levels of 60 healthy controls and 14 children with epilepsy receiving carbamazepine."3.73Valproate-induced eosinophilia in children with epilepsy: role of interleukin-5. ( Bourantas, KL; Kateri, MD; Makis, AC; Papadopoulou, ZL; Tzoufi, M, 2005)
" However, he was found to have hyperammonemia within 2 weeks after the addition of low-dose topiramate to valproate."3.73Topiramate-valproate-induced hyperammonemic encephalopathy syndrome: case report. ( Cheung, E; Fung, CW; Wong, V, 2005)
"Across a range of assumptions used, the risk of hospitalization for Stevens-Johnson syndrome or toxic epidermal necrolysis in new users is low for carbamazepine, lamotrigine, phenytoin, phenobarbital, and valproic acid."3.73Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptics. ( Messenheimer, J; Mockenhaupt, M; Schlingmann, J; Tennis, P, 2005)
"This study evaluated the effect of the addition of zonisamide on valproic acid (valproate sodium) pharmacokinetics under steady-state conditions in patients with epilepsy."3.73Lack of pharmacokinetic interactions between steady-state zonisamide and valproic acid in patients with epilepsy. ( Brodie, M; Grundy, JS; Levy, RH; Ragueneau-Majlessi, I; Shah, J; Smith, D, 2005)
"To evaluate whether the administration of lamotrigine (LTG) or valproate (VPA) changes concentrations of plasma total homocysteine (tHcy), plasma and red-cell folate and plasma Vitamin B-12, we measured these indices in a total of 20 patients with epilepsy before and after a 32-week period of monotherapy of LTG or VPA."3.73Blood homocysteine, folate and vitamin B-12 concentrations in patients with epilepsy receiving lamotrigine or sodium valproate for initial monotherapy. ( Gidal, BE; Hammer, A; Tamura, T; Vuong, A, 2005)
"Serum concentrations of valproate were reduced and seizures were exacerbated by concomitant meropenem therapy in a child with a neurodegenerative disorder and epilepsy."3.73Seizure worsening caused by decreased serum valproate during meropenem therapy. ( Parmeggiani, A; Riva, R; Santucci, M, 2005)
" Replacement of phenytoin by valproic acid resulted in a 100-lb weight gain, exacerbation of sleep apnea, and right heart failure."3.73Lethal obesity associated with sodium valproate in a brain-injured patient. ( Althoff, RR; Black, DN; Daye, K; Pelletier, CA, 2005)
"Valproic acid has been widely used for the treatment of epilepsy."3.73[Hyperammonemia secondary to the use of valproic acid: case report]. ( Fernandes, RM; Funayama, CA; Turcato, Mde F; Wichert-Ana, L, 2005)
"The aim of the study was to obtain pharmacokinetic data for carbamazepine (CBZ) and its fractions not bound with proteins in bitherapy with lamotrigine (LTG), topiramate (TPM), vigabatrin (VGB) or valproic acid (VPA) in children and adolescents treated for epilepsy."3.73Pharmacokinetic interactions of carbamazepine with some antiepileptic drugs during epilepsy treatment in children and adolescents. ( Steinborn, B, 2005)
"Five patients with idiopathic generalized epilepsies (IGE) treated with lamotrigine (LTG) experienced exacerbation or de novo appearance of myoclonic jerks (MJ)."3.73Lamotrigine associated with exacerbation or de novo myoclonus in idiopathic generalized epilepsies. ( Baldy-Moulinier, M; Berramdane, M; Coubes, P; Crespel, A; Gelisse, P; Genton, P; Monicard, C, 2005)
"Authors presented the data on the efficacy and tolerability of the new anticonvulsant drug topiramate (topamax) in the treatment of 110 children aged from 6 months to 16 years with pharmacoresistant types of epilepsy including 42 patients with tuberous sclerosis."3.73[The efficacy of topiramate (topamax) in the treatment of resistant epilepsy in children]. ( Belousova, ED; Dorofeeva, MIu; Ermakov, AIu, 2005)
" We identified a patient with a positive family history for episodic ataxia, who was originally diagnosed with epilepsy and treated with valproic acid."3.73CACNA1A mutation in a EA-2 patient responsive to acetazolamide and valproic acid. ( Bulman, DE; Friedman, JH; Scoggan, KA, 2006)
") continuous valproic acid (VPA) infusion, as compared with acute injections in the kindling epilepsy model."3.73Effect of intracerebroventricular continuous infusion of valproic acid versus single i.p. and i.c.v. injections in the amygdala kindling epilepsy model. ( Alós, M; Barcia, JA; Durán, C; Hernández, ME; Ortiz, P; Serralta, A, 2006)
"To evaluate the influence of aging on the pharmacokinetics of valproic acid (VPA) at steady-state and on the susceptibility of VPA metabolism to enzyme induction by antiepileptic comedication."3.73The influence of old age and enzyme inducing comedication on the pharmacokinetics of valproic acid at steady-state: A case-matched evaluation based on therapeutic drug monitoring data. ( Battino, D; Croci, D; Fattore, C; Mamoli, D; Messina, S; Perucca, E, 2006)
"A 55-year-old woman was diagnosed with pneumonia and was treated with meropenem; 5 days later she developed epileptic seizures."3.73Epileptic seizures caused by low valproic acid levels from an interaction with meropenem. ( Carcas, A; Fudio, S; Ortega, R; Piñana, E, 2006)
"Morning urine samples were collected from children with epilepsy receiving VPA (n = 25), carbamazepine (n = 16), or clobazam (n = 12) for > or = 4 weeks and from age-matched control subjects (n = 39)."3.73Oxidative stress in children receiving valproic acid. ( Abbott, FS; Chang, TK; Farrell, K; Michoulas, A; Teng, XW; Tong, V, 2006)
"In order to evaluate the results of epilepsy treatment in children and adolescents the influence of two antiepileptic drugs (AED) carbamazepine (CBZ) and valproates (VPA) on cognitive functions of epileptic children and adolescents was analyzed."3.73[Long latency auditory evoked potentials in schoolchildren and adolescents with epilepsy]. ( Zgorzalewicz, M, 2006)
" The mother had been treated with valproic acid (1800mg per day) and lamotrigine (100mg per day) throughout pregnancy."3.72Valproic acid and lamotrigine treatment during pregnancy. The risk of chromosomal abnormality. ( Cogulu, O; Gunduz, C; Kultursay, N; Ozkinay, F; Yilmaz, D, 2003)
"This open-label, cross-sectional study compared (1) endocrine and lipid measures during the early follicular phase of the menstrual cycle; (2) prevalence of menstrual disorders (from patient diaries recorded over three cycles); and (3) body weight of women with epilepsy on lamotrigine monotherapy (n=119) with those on valproate monotherapy (n=103) for <5 years."3.72Higher androgens and weight gain with valproate compared with lamotrigine for epilepsy. ( Ayala, R; Dam, M; Gomez, G; Isojärvi, J; Messenheimer, J; Morrell, MJ; O'Neill, F; Taylor, AE; Tennis, P, 2003)
"This study aimed to assess the risks and benefits of the co-administration of lamotrigine and valproate in a pediatric population with refractory epilepsy."3.72Lamotrigine and valproate: efficacy of co-administration in a pediatric population. ( Fiore, LA; Freitas, A; Thomé-Souza, S; Valente, KD, 2003)
"A 5-year-old female developed alteration of consciousness during 3 days of long-term treatment with valproic acid for localization-related epilepsy."3.72Reversible altered consciousness with brain atrophy caused by valproic acid. ( Eguchi, M; Imataka, G; Nakagawa, E; Ota, T; Yamanouchi, H, 2003)
"A group of 105 women (54 of whom were, and had only ever been, taking valproate for at least a year, and 51 who had only ever taken either lamotrigine or carbamazepine, for at least a year) were compared with a group of 50 women who did not have epilepsy: any oral contraceptive taken at the time of testing was recorded and blood levels of follicle stimulating hormone (FSH), luteinising hormone (LH), testosterone and prolactin were estimated from days 2 to 6 of the menstrual cycle (day 1 being the first day of bleeding) and an MRI scan made of their pelvis."3.72A study of anticonvulsant medication on ovarian function in a group of women with epilepsy who have only ever taken one anticonvulsant compared with a group of women without epilepsy. ( Betts, T; Dutton, N; Greenhill, L; Rolfe, T; Yarrow, H, 2003)
"Two months-old girl with psychomotor retardation had aminophylline-resistant apnea attacks and was investigated by video-EEG recording."3.72[A case of infantile epileptic apnea with congenital brain anomaly]. ( Hamano, K; Iwasaki, N; Matsui, A; Ohto, T; Takahashi, M; Tanaka, R, 2003)
"0803 * INDI, in which CBZ indicates co-administration of carbamazepine, VPADD the daily dose of VPA and INDI uncontrolled epilepsy."3.72Pharmacokinetic modelling of valproic acid from routine clinical data in Egyptian epileptic patients. ( Cosson, V; EL Desoky, ES; EL Din Amry, S; Fuseau, E, 2004)
"To investigate the effect of antiepileptic drugs, especially carbamazepine and valproate, on intelligence in prenatally exposed children of mothers with epilepsy."3.72Normal intelligence in children with prenatal exposure to carbamazepine. ( Bardy, A; Gaily, E; Granström, ML; Hiilesmaa, V; Isoaho, M; Kaaja, E; Kantola-Sorsa, E; Kotila, M; Matila, R; Nylund, T, 2004)
"A 70-year-old woman under anticonvulsive therapy with carbamazepine and valproate was diagnosed as polymyalgia rheumatica."3.72[A case of polymyalgia rheumatica with improved steroid-responsibility after discontinuing carbamazepine]. ( Katada, S; Kobayashi, H; Sato, A; Sato, M, 2004)
"Dizocilpine inhibits the seizure of the amygdala kindling and improve the antiepileptic activity of phenobarbital, valproate and nicardipine, indicating that these combination may provide a new approach for treating epilepsy."3.72Effect of combination of dizocilpine with general antiepileptic drugs on amygdala kindling models in rats. ( Gao, GM; Yang, ZH; Yue, W; Zhao, YJ; Zhong, WZ, 2004)
"To investigate the possible role of valproic acid therapy in the development of the weight gain and hyperinsulinemia of epileptic patients."3.72[Insulin resistance in epileptic patients during treatment of valproic acid]. ( Bao, YY; Chen, Z; Ding, MP; Liu, ZR; Xu, LL, 2004)
" Twenty-eight patients were taking carbamazepine (CBZ); five, lamotrigine (LTG); 12, oxcarbazepine (OXC); and 25, valproate (VPA) as monotherapy for epilepsy."3.72Serum androgen levels and testicular structure during pubertal maturation in male subjects with epilepsy. ( Isojärvi, JI; Mikkonen, K; Päivänsalo, M; Pakarinen, AJ; Tapanainen, P; Vainionpää, LK, 2004)
" Anthropometric measurements, staging of pubertal maturation, and clinical manifestations of hyperandrogenism were assessed, as well as measurement of serum levels of testosterone, dehydroepiandrosterone sulfate (DHEAS), sex hormone-binding globulin (SHBG), and free androgen index (FAI)."3.72Physical growth and endocrinal disorders during pubertal maturation in girls with epilepsy. ( Abd El-Basset, FZ; El Barbary, NS; El-Khayat, HA; Hakky, SM; Mohamed, MS; Nassef, NM; Tohamy, SM; Tomoum, HY; Zaky, AA, 2004)
"The nootropic drug piracetam was investigated in various experimental models of epilepsy."3.72Effects of piracetam alone and in combination with antiepileptic drugs in rodent seizure models. ( De Sarro, G; Fischer, W; Kittner, H; Regenthal, R; Russo, E, 2004)
" In five multiple-dose studies in healthy subjects (n=82) and epilepsy patients (n=86) the estimates of divalproex-ER/divalproex ratios for steady-state 24 h valproic acid area under the curve (AUC) central values, maximum concentration (C(max)) central values and minimum concentration (C(min)) means had ranges of 0."3.72Bioavailability of divalproex extended-release formulation relative to the divalproex delayed-release formulation. ( Dutta, S; Zhang, Y, 2004)
" After adjustment for prior fracture, use (ever) of corticosteroids, comorbidity, social variables, and diagnosis of epilepsy, carbamazepine [CBZ; odds ratio (OR), 1."3.72Fracture risk associated with use of antiepileptic drugs. ( Mosekilde, L; Rejnmark, L; Vestergaard, P, 2004)
"In the past 6 years, 11 children on valproic acid have developed pancreatitis in our children's hospital."3.72Valproic acid-induced pancreatitis in childhood epilepsy: case series and review. ( Berg, M; Breault, R; Sinclair, DB, 2004)
"The study aimed at a comparative analysis of safety and efficacy of valproic acid (valproate) and barbiturates in the treatment of epilepsy in children."3.72[Efficacy and safety of antiepileptic therapy in children (a comparative analysis of valproates and barbiturates)]. ( Petrukhin, AS; Pylaeva, OA; Voronkova, KV, 2004)
" Valproic acid (VPA) is a very effective anticonvulsant agent widely used in the management of various forms of epilepsy."3.72Effect of long-term therapy with sodium valproate on nail and serum trace element status in epileptic children. ( Akyol, O; Armutcu, F; Gurel, A; Kanter, M; Ozerol, E; Vural, H; Yakinci, C, 2004)
"Valproic acid is increasingly used in the treatment of epilepsy, and also prescribed for bipolar affective disorders, schizoaffective disorders, schizophrenia and migraine prophylaxis."3.72Valproic acid intoxication: sense and non-sense of haemodialysis. ( Boerma, EC; Broekroelofs, J; Egbers, PH; Meek, MF; van der Voort, PH; Yska, JP, 2004)
"In order to investigate the possible role of valproic acid therapy in the development of obesity, hyperinsulinism and polycystic ovaries (PCOs), we have studied metabolic parameters and ovarian morphology in epileptic women."3.71Polycystic ovaries, obesity and insulin resistance in women with epilepsy. A comparative study of carbamazepine and valproic acid in 105 women. ( Abraham, I; Alge, A; Bauer, G; Haslinger, M; Lechleitner, M; Luef, G; Seppi, K; Trinka, E; Unterberger, I; Windisch, J, 2002)
"The aim of this study was to obtain a pharmacokinetic calculation for valproic acid (VPA) and its free fraction in 50 children and adolescents (4-18 years) treated for epilepsy in VPA monotherapy and bitherapy with carbamazepine (CBZ)."3.71Studies on the pharmacokinetics of total and free valproate in mono- and bitherapy with carbamazepine in epileptic children and adolescents. ( Galas-Zgorzalewicz, B; Steinborn, B, 2002)
"In this study, serum triglyceride, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), vitamin B12 and folic acid levels were studied in children with epilepsy who had been receiving long-term valproate (VPA) therapy."3.71Serum lipids, vitamin B12 and folic acid levels in children receiving long-term valproate therapy. ( Caksen, H; Geda, G; Içağasioğlu, D, 2002)
" A cohort study comparing life expectancy of males and females with cerebral palsy and a systematic review of five trials comparing two anti-epileptic drugs, carbamazepine and sodium valproate, are used for illustration."3.71Aggregate data meta-analysis with time-to-event outcomes. ( Hutton, JL; Marson, AG; Smith, CT; Williamson, PR, 2002)
"In this experiment, we studied the effect of valproate (VPA) on weight gain, and serum leptin levels in prepubertal epileptic children receiving VPA."3.71Does long-term use of valproate cause weight gain in prepubertal epileptic children? ( Berberoğlu, M; Caksen, H; Deda, G, 2002)
"In this study, we studied serum calcium, phosphorus, alkaline phosphatase, thyroid hormones (total thyroxine, free thyroxine, thyroid-stimulating hormone), parathyroid hormone, and osteocalcine levels in children with epilepsy who had been receiving long-term valproate (VPA) therapy in order to determine whether there was any effect of VPA therapy on these hormones."3.71No effect of long-term valproate therapy on thyroid and parathyroid functions in children. ( Ataş, B; Caksen, H; Cesur, Y; Dülger, H; Odabaş, D; Tuncer, O, 2002)
" Patients with high-grade gliomas were treated with up-front chemotherapy regimen consisting of fotemustine (d3: 100 mg/m2), cisplatin (d1-3: 33 mg/m2) and etoposide (d1-3: 75 mg/m2) followed by whole brain radiotherapy at progression."3.71Nitroso-urea-cisplatin-based chemotherapy associated with valproate: increase of haematologic toxicity. ( Bourg, V; Chichmanian, RM; Frenay, M; Lebrun, C; Thomas, P, 2001)
"A 15-year-old boy with epilepsy and cerebral calcifications, treated with valproic acid, ethyl phenylbarbiturate and ethosuximide, was referred for drug induced systemic lupus erythematosus."3.71Latent coeliac disease in a child with epilepsy, cerebral calcifications, drug-induced systemic lupus erythematosus and intestinal folic acid malabsorption associated with impairment of folic acid transport across the blood-brain barrier. ( Calvani, M; Guaitolini, C; Paolone, G; Parisi, G; Parisi, P, 2001)
"Perimenstrual catamenial epilepsy may in part be due to withdrawal of the endogenous progesterone-derived neurosteroid allopregnanolone that potentiates gamma-aminobutyric acidA (GABA(A)) receptor-mediated inhibition."3.71Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy. ( Reddy, DS; Rogawski, MA, 2001)
"It is not known whether polytherapy with carbamazepine (CBZ) and valproate (VPA) increases the risk of thrombocytopenia."3.71Severe, isolated thrombocytopenia under polytherapy with carbamazepine and valproate. ( Finsterer, J; Hess, B; Pelzl, G, 2001)
"Carbamazepine and valproic acid are effective antiepileptic drugs for treating many types of epilepsy."3.71Thyroid hormones in epileptic children receiving carbamazepine and valproic acid. ( Basciani, F; Chiarelli, F; Morgese, G; Morresi, S; Verrotti, A, 2001)
" This study aimed to evaluate thyroid function in men taking carbamazepine (CBZ), oxcarbazepine (OCBZ), or valproate (VPA) for epilepsy."3.71Thyroid function in men taking carbamazepine, oxcarbazepine, or valproate for epilepsy. ( Isojärvi, JI; Kotila, M; Myllylä, VV; Pakarinen, AJ; Rättyä, J; Turkka, J, 2001)
"Long-term treatment with valproate (VPA) or carbamazepine (CBZ) may induce reproductive endocrine disorders in patients with epilepsy."3.71Early hormonal changes during valproate or carbamazepine treatment: a 3-month study. ( Isojärvi, JI; Knip, M; Myllylä, VV; Pakarinen, AJ; Rättyä, J; Repo-Outakoski, M, 2001)
"To determine whether long-term treatment with valproate (VPA) and/or lamotrigine (LTG) in children with epilepsy is associated with altered growth and/or bone metabolism."3.71Long-term valproate and lamotrigine treatment may be a marker for reduced growth and bone mass in children with epilepsy. ( Atkinson, SA; Guo, CY; Ronen, GM, 2001)
"To examine bone development in children and adolescents who have uncomplicated idiopathic epilepsy and had received monotherapy with carbamazepine or valproic acid for at least 1 year."3.71Analysis of the musculoskeletal system in children and adolescents receiving anticonvulsant monotherapy with valproic acid or carbamazepine. ( Herkenrath, P; Rauch, F; Rieger-Wettengl, G; Schauseil-Zipf, U; Schoenau, E; Stabrey, A; Tutlewski, B, 2001)
"Dynamics of carbamazepine and valproic acid concentrations in the middle of follicular and lutein menstrual cycle phases has been studied in women with epilepsy, aged 21-30 years."3.71[Pharmacokinetic aspects of carbamazepine and valproic acid using in reproductive-age women with epilepsy]. ( Karlov, VA; Sokolov, AV; Tishchenkova, IF; Vlasov, PN, 2002)
"Valproic acid is commonly used in the management of childhood epilepsy."3.71Coagulation abnormalities and acquired von Willebrand's disease type 1 in children receiving valproic acid. ( Kavakli, K; Serdaroglu, G; Tekgül, H; Tütüncüoglu, S, 2002)
"We present three children with severe therapy-refractory epilepsy who tolerated valproate (VPA) well in various combinations with other antiepileptic drugs (AEDs) but developed typical VPA side effects in combination with topiramate (TPM)."3.71Topiramate enhances the risk of valproate-associated side effects in three children. ( Koelfen, W; König, S; Longin, E; Teich, M, 2002)
" Leptin is considered a signaling factor regulating body weight and energy metabolism."3.71Serum insulin and leptin levels in valproate-associated obesity. ( Isojärvi, JI; Knip, M; Kotila, M; Pakarinen, A; Pylvänen, V; Turkka, J, 2002)
"Valproic acid is effective for treatment of many types of epilepsy, but its use in epileptic patients can be associated with an increase in body weight that could interfere with treatment compliance."3.71Insulin resistance in epileptic girls who gain weight after therapy with valproic acid. ( Basciani, F; Chiarelli, F; De Simone, M; Morgese, G; Trotta, D; Verrotti, A, 2002)
"To determine whether children with epilepsy undergoing valproate (VPA) antiepileptic therapy and who are otherwise healthy have a lower serum level of carnitine (CAR) and a higher plasma level of plasma ammonia than do normal children."3.70Valproate therapy does not deplete carnitine levels in otherwise healthy children. ( Hirose, S; Mitsudome, A; Muta, Y; Ogawa, A; Tomoda, Y; Yasumoto, S, 1998)
"To evaluate the interictal autonomic nervous system function in 84 patients with epilepsy: 37 with newly diagnosed, previously untreated epilepsy, and 47 patients receiving long-term carbamazepine (CBZ), phenytoin (PHT), or valproate (VPA) monotherapy, or CBZ plus PHT, or CBZ plus VPA for their seizure disorder."3.70Interictal cardiovascular autonomic responses in patients with epilepsy. ( Ansakorpi, H; Isojärvi, JI; Myllylä, VV; Repo, M; Suominen, K; Tolonen, U, 1998)
"In November 1996, a panel of pediatric neurologists met to update the consensus statement issued in 1989 by a panel of neurologists and metabolic experts on L-carnitine supplementation in childhood epilepsy."3.70L-carnitine supplementation in childhood epilepsy: current perspectives. ( Bohan, TP; Coulter, DL; De Vivo, DC; Dreifuss, FE; Greenwood, RS; Nordli, DR; Shields, WD; Stafstrom, CE; Tein, I, 1998)
"To review (retrospectively) the relationships between lamotrigine (LTG) dosage and plasma concentrations based on data generated in a routine therapeutic drug monitoring laboratory from a heterogeneous sample of patients with epilepsy."3.70Lamotrigine and therapeutic drug monitoring: retrospective survey following the introduction of a routine service. ( Batty, AB; Black, AB; Harris, AL; Morris, RG; Sallustio, BC, 1998)
"Forty girls taking valproate (VPA), 19 girls taking carbamazepine (CBZ), and 18 girls taking oxcarbazepine (OXC) for epilepsy and 49 healthy control girls participated in the study, which included a cross-sectional clinical examination when the girls were 8 to 18 years old and a longitudinal growth analysis from the age of 1 year."3.70The effects of valproate, carbamazepine, and oxcarbazepine on growth and sexual maturation in girls with epilepsy. ( Isojärvi, JI; Knip, M; Lanning, P; Rättyä, J; Vainionpää, L, 1999)
"A pregnant woman with epilepsy receiving VPA and ethosuximide (ESM) was given high-dose multivitamins from 13 to 28 weeks' gestation."3.70Valproate-induced biochemical abnormalities in pregnancy corrected by vitamins: a case report. ( Baggot, PJ; Kalamarides, JA; Shoemaker, JD, 1999)
"A population analysis of the kinetics of valproic acid (VPA) in children with epilepsy was performed in order to characterize the covariates which influence VPA clearance (CL)."3.70Valproate population pharmacokinetics in children. ( Buelga, DS; Domínguez-Gil, A; García Sánchez, MJ; Otero, MJ; Serrano, BB; Serrano, J, 1999)
"Neural tube defects (NTDs) are the most common of the major anomalies associated with in utero exposure to valproic acid."3.70Safe use of valproic acid during pregnancy. ( Kennedy, D; Koren, G, 1999)
"Weight gain has been recognized as an adverse effect of valproic acid therapy, but there are are no data about serum leptin levels in patients receiving this drug."3.70Serum leptin changes in epileptic patients who gain weight after therapy with valproic acid. ( Basciani, F; Chiarelli, F; de Martino, M; Morgese, G; Morresi, S; Verrotti, A, 1999)
"We previously encountered a patient with epilepsy who exhibited rapid elimination of sustained-release valproic acid (VPA) administered at the dose of 2."3.70Valproic acid elimination rate and urinary excretion of its glucuronide conjugate in patients with epilepsy. ( Akiyama, T; Hayashi, T; Hirozane, K; Kamiya, A; Katayama, H; Kimoto, H; Watanabe, M; Yoshida, H; Yoshitomi, H, 1999)
"We determined serum levels of triiodothyronine (T3), thyroxine (T4), free thyroxine (FT4), thyroxine-binding globulin (TBG), and thyroid-stimulating hormone (TSH) in 148 healthy children and 141 children with epilepsy who had been receiving CBZ (61 patients), VPA (51 patients), or PB (29 patients) for 12-161 months."3.70Long-term treatment of children with epilepsy with valproate or carbamazepine may cause subclinical hypothyroidism. ( Castro-Gago, M; Del Río-Garma, M; Del Río-Garma, MC; Eirís-Puñal, J; Lojo-Rocamonde, S; Novo-Rodríguez, I, 1999)
"Two adult patients with focal epilepsy who tolerated valproate (VPA) well in different combinations of anticonvulsants developed hyperammonemic encephalopathy when treated with VPA in combination with topiramate (TPM)."3.70Valproate-induced hyperammonemic encephalopathy in the presence of topiramate. ( Hamer, HM; Knake, S; Rosenow, F; Schomburg, U, 2000)
"A 24-years-old woman with epilepsy treated with valproic acid developed disorientation, acalculia, perseveration, slow responsiveness and loss of memory."3.70[A case report of valproate encephalopathy]. ( Hirata, K; Katayama, S; Miyamoto, M; Miyamoto, T, 1999)
" We report two cases of an adverse effect of dyskinesia and bruxism when MPH was given to children maintained on valproic acid."3.70Adverse response to methylphenidate in combination with valproic acid. ( Gara, L; Roberts, W, 2000)
"Our data indicate that not only fasting but also 6h-PML tHcy levels should be determined in order to identify hyperhomocysteinemia among patients on AEDs."3.70Homocysteine concentrations and methionine loading in patients on antiepileptic drugs. ( Apeland, T; Kristensen, O; Mansoor, MA; Strandjord, RE, 2000)
"Perimenstrual catamenial epilepsy, the exacerbation of seizures in association with menstruation, may in part be due to withdrawal of the progesterone metabolite allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one), an endogenous anticonvulsant neurosteroid that is a positive allosteric modulator of gamma-aminobutyric acid(A) receptors."3.70Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy. ( Reddy, DS; Rogawski, MA, 2000)
"Twenty epileptic women were treated with valproate only during pregnancy and two were treated with valproate and carbamazepine."3.70Neonatal hypoglycaemia and withdrawal symptoms after exposure in utero to valproate. ( Ebbesen, F; Holsteen, V; Hoseth, E; Joergensen, A; Kaad, PH; Moeller, M; Rix, M, 2000)
" The fact that valproic acid, a derivative of pentanoic acid, also induces gamma-globin expression suggests that short-chain fatty acid derivatives that are already approved for human use may possess the property of gamma-globin inducibility and may be of therapeutic relevance to the beta-chain hemoglobinopathies."3.69Stimulation of fetal hemoglobin production by short chain fatty acids. ( Blau, CA; Dover, G; Fournarakis, B; Josephson, B; Li, Q; Liakopoulou, E; Papayannopoulou, T; Raisys, V; Stamatoyannopoulos, G; Wolf, JA, 1995)
"Axial (second, third, and fourth lumbar vertebrae) and appendicular (distal third of radius) bone mineral density was measured by dual-energy x-ray absorptiometry in 27 healthy children and 26 children with uncomplicated idiopathic epilepsy treated with either carbamazepine (n = 13) or valproate (n = 13) for more than 18 months."3.69Effect of carbamazepine and valproate on bone mineral density. ( Bodensteiner, JB; Hobbs, GR; Jacob, JC; Penney, S; Riggs, JE; Sheth, RD; Wesolowski, CA, 1995)
"A girl with intractable epilepsy who received high dose valproic acid showed bone marrow suppression, which improved after the end of valproic acid treatment and the administration of supportive treatments."3.69Bone marrow suppression induced by high dose valproic acid. ( Fujita, N; Ishimae, M; Kawaguchi, H; Kishi, T; Tanaka, T; Watanabe, K, 1994)
"We report a newborn with isolated aplasia cutis congenita of the scalp whose mother was treated with valproic acid during pregnancy."3.69Aplasia cutis congenita of the scalp in an infant exposed to valproic acid in utero. ( Berthier, M; Bonneau, D; Couet, D; Hubert, A; Larrègue, M; Oriot, D, 1994)
"Three patients who developed chorea during long-term treatment with valproic acid."3.69Choreiform movements associated with the use of valproate. ( Asconapé, JJ; Lancman, ME; Penry, JK, 1994)
"Chemotherapy with a combination of synthetic ACTH (ACTH-Zn) and valproic acid (VPA) induced remarkable hypofibrinogenemia in three children (5 months, 8 months, and 5 years and 10 months old) with intractable epilepsy."3.69[Three cases of hypofibrinogenemia induced by chemotherapy with a combination of synthetic ACTH and valproic acid]. ( Kodani, N; Ogino, T; Tokuda, K, 1994)
"To evaluate the population pharmacokinetics of valproic acid in children, 97 steady-state serum valproate concentration measurements were gathered during normal, routine, outpatient care of 52 children with epilepsy (1."3.69A model for estimating individualized valproate clearance values in children. ( Botha, JH; Gray, AL; Miller, R, 1995)
"The interaction between clearance of phenytoin, valproic acid, phenobarbital and carbamazepine, and changes in body weight was determined in a 19-year-old obese woman with epilepsy (body weight 93 kg, BMI 36."3.69Clearance of phenytoin and valproic acid is affected by a small body weight reduction in an epileptic obese patient: a case study. ( Ashikari, Y; Chiba, S; Kodama, Y; Kuranari, M; Sakata, T; Takeyama, M, 1996)
"This study was performed to evaluate the aggregation changes in the whole blood samples of children with epilepsy receiving valproic acid."3.69The platelet aggregation in children with epilepsy receiving valproic acid. ( Akin, R; Gokcay, E; Koseoglu, V; Kurekci, AE; Ozcan, O; Tanindi, S, 1996)
"Because binding of valproic acid to plasma proteins affects the efficacy of the drug in the treatment of epilepsy (only the unbound fraction of the drug is effective) we have compared two methods which use different binding parameters to predict the in-vivo concentration of unbound valproic acid in serum."3.69Comparison of two binding equations for prediction of the concentration of unbound valproic acid in the serum of adult epileptic polytherapy patients. ( Fujii, I; Kodama, H; Kodama, Y; Kuranari, M; Takeyama, M; Yukawa, E; Zaizen, T, 1996)
"Twelve women receiving stable valproic acid (VPA) monotherapy for epilepsy received a combination norethindrone 1."3.69Effect of topiramate on the pharmacokinetics of an oral contraceptive containing norethindrone and ethinyl estradiol in patients with epilepsy. ( Doose, DR; Nayak, RK; Rosenfeld, WE; Walker, SA, 1997)
"We report the effects of two new dihydropyridine derivatives, isradipine (4-(4'-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedic arboxylic acid methylisopropylester) and niguldipine (1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid 3-(4,4-diphenyl-1-piperidinyl)-propyl methyl ester hydrochloride), and of dantrolene (1-[(5-[p-nitrophenyl]furfurylidene)-amino]hydantoin sodium, an inhibitor of Ca2+ release from intracellular stores) on the protective efficacy of antiepileptic drugs against maximal electroshock-induced seizures."3.69Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice. ( Borowicz, KK; Czuczwar, SJ; Gasior, M; Kleinrok, Z, 1997)
" Eighty patients presenting with epilepsy received monotherapies of valproic acid, phenytoin, or carbamazepine; 18 patients did not receive antiepileptic drug therapy."3.69Color vision tests for early detection of antiepileptic drug toxicity. ( Bayer, AU; Dichgans, J; Kuehn, M; Paulus, W; Ried, S; Schmidt, D; Thiel, HJ; Zrenner, E, 1997)
"Serum lipids were determined in 10 untreated patients with recently diagnosed epilepsy, 21 patients treated with carbamazepine (CBZ), 10 patients treated with valproate (VPA) and in 15 healthy children."3.69The effects of long-term anticonvulsive treatment on serum lipid profile. ( Hassanzadeh, A; Mawlud, K; Yalçin, E, 1997)
"Serum total cholesterol (TC), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C) and very low-density lipoprotein cholesterol, triglyceride, apolipoproteins A1 and B levels were studied in 57 healthy children and in 39 children with epilepsy who had been receiving carbamazepine (CBZ) (23 children) for 1."3.69Serum lipids in epileptic children treated with carbamazepine and valproate. ( Arpaci, B; Atakil, D; Baybas, S; Dogu, O; Sözüer, DT, 1997)
"Auditory event related potentials were recorded in 40 patients with idiopathic generalized epilepsy, 20 on monotherapy with sodium valproate (VPA), 20 on monotherapy with carbamazepine and 20 age and sex matched controls."3.69Auditory event related potentials in patients with epilepsy on sodium valproate monotherapy. ( Karageorgiou, CL; Panagopoulos, GR; Tagaris, G; Thomaides, T, 1997)
" The multiple peak approach has been used to evaluate the effect of age, total body weight, dose, gender and comedication (carbamazepine-induced change) on population estimates of valproic acid relative clearance."3.69Detection of carbamazepine-induced changes in valproic acid relative clearance in man by simple pharmacokinetic screening. ( Aoyama, T; Higuchi, S; Honda, T; Ohdo, S; Yukawa, E, 1997)
"Very little data are available on the usefulness of oxcarbazepine in young children with epilepsy."3.69Oxcarbazepine in the treatment of early childhood epilepsy. ( Gaily, E; Granström, ML; Liukkonen, E, 1997)
"Nonlinear mixed effects modeling (NONMEM) was used to estimate the effects of drug-drug interaction on valproic acid relative clearance values using 792 serum levels gathered from 400 pediatric and adult patients with epilepsy (age range, 0."3.69Population-based investigation of valproic acid relative clearance using nonlinear mixed effects modeling: influence of drug-drug interaction and patient characteristics. ( Aoyama, T; Higuchi, S; Ohdo, S; To, H; Yukawa, E, 1997)
"Information from standardised tests of intelligence, school attainments, attention, memory and visuomotor function, together with parent and teacher questionnaire information about various aspects of behaviour, was obtained for 63 schoolchildren with newly diagnosed epilepsy before treatment with sodium valproate or carbamazepine, and again at intervals for a total period of 12 months."3.68Psychological effects of sodium valproate and carbamazepine in epilepsy. ( Stores, G; Styles, E; Williams, PL; Zaiwalla, Z, 1992)
"We retrospectively collected plasma level assessments performed in 96 adult patients with epilepsy on stable monotherapy, including 9 patients on clobazam (CLB), 34 on carbamazepine (CBZ), 24 on phenobarbital (PB), 9 on phenytoin (PHT), and 20 on valproate (VPA); these results were compared to those obtained in 54 adult patients on stable bitherapy with the association of CLB with either CBZ (n = 17), PB (n = 17), PHT (n = 5), or VPA (n = 15)."3.68Interactions between clobazam and standard antiepileptic drugs in patients with epilepsy. ( Bonneton, J; Dravet, C; Genton, P; Mesdjian, E; Roger, J; Sennoune, S, 1992)
" Spina bifida aperta has been linked specifically to valproic acid (VPA) (estimated risk, 1 to 2%)."3.68The risk of spina bifida aperta after first-trimester exposure to valproate in a prenatal cohort. ( Brandenburg, H; Gaillard, HL; Grobbee, DE; Jahoda, MG; Los, FJ; Omtzigt, JG; Pijpers, L; Sachs, ES; Stewart, PA; Wladimiroff, JW, 1992)
"We report the case of a young man suffering from epilepsy who developed chronic calcified pancreatitis after ten years of therapy with the anticonvulsant drugs carbamazepine and phenytoin."3.68Anticonvulsant-induced chronic pancreatitis. A case report. ( Billi, P; Broccoli, PL; Fontana, G; Melandri, R; Pezzilli, R, 1992)
"In newly diagnosed adult patients with epilepsy followed prospectively on monotherapy, carbamazepine and phenytoin were associated with a fall in plasma uric acid, but sodium valproate and phenobarbitone were associated with a rise in plasma uric acid."3.68Plasma uric acid in patients receiving anticonvulsant monotherapy. ( Heller, AJ; Johnson, AL; Marshall, WJ; Reynolds, EH; Ring, HA, 1991)
"The effects of antiepileptic drugs (AED) on infants during pregnancy and delivery were studied in a total of 82 epileptic mothers on various monotherapies; 29 cases receiving valproic acid (VPA), 20 receiving phenytoin (PHT), 18 on carbamazepine (CBZ) and 15 on phenobarbital (PB)."3.68[Effects of antiepileptic drugs on delivery and early childhood--comparison among mono-therapies of valproic acid, phenytoin, carbamazepine and phenobarbital]. ( Ishikawa, S; Izumi, M; Okada, H; Takeda, A; Tanaka, H, 1991)
"The case of a mentally handicapped female patient is presented who developed typical pellagra with dermatitis, diarrhoea and mental alteration following a long-term antiepileptic treatment with phenytoin, ethosuximide and valproic acid."3.68[Pellagra in anticonvulsive therapy]. ( Bartels, H; Hebestreit, H; Mingers, AM; Pannenbecker, J, 1990)
"Oxiracetam, a nootropic drug, could be of potential use in the treatment of memory disturbances in patients with epilepsy who are using antiepileptic drugs."3.68Pilot study to determine the interaction of oxiracetam with antiepileptic drugs. ( Meijer, JW; van Emde Boas, W; van Wieringen, A; Vermeij, TA, 1990)
" This is a syndrome of idiopathic generalized epilepsy that responds to treatment with valproic acid."3.68Eyelid twitching seizures and generalized tonic-clonic convulsions: a syndrome of idiopathic generalized epilepsy. ( Ferrendelli, JA; Miller, JW, 1990)
"Free and total carbamazepine (CBZ) and carbamazepine-epoxide (CBZ-EP) plasma levels were obtained on 113 patients with epilepsy (18-61 years old) controlled on either monotherapy or coadministration with either phenobarbital (PB), phenytoin (PHT), valproic acid (VPA), or all three."3.68Carbamazepine metabolism in humans: effect of concurrent anticonvulsant therapy. ( Briggle, TV; Guterman, A; McManus, DQ; Perchalski, R; Ramsay, RE; Vazquez, D; Wong, P; Yost, RA, 1990)
"An infant with dysmorphic features was born to an epileptic mother who had taken phenytoin and sodium valproate throughout pregnancy."3.68Neocerebellar hypoplasia in a neonate following intra-uterine exposure to anticonvulsants. ( Hope, PL; Lindenbaum, RH; Squier, W, 1990)
"The anticonvulsant potency of 2-propyl-2-pentenoic acid (2-en-VPA; trans isomer), a major metabolite of the antiepileptic valproic acid (VPA), was evaluated in different animal models of epilepsy and compared with the respective data for VPA."3.67Comparative evaluation of anticonvulsant and toxic potencies of valproic acid and 2-en-valproic acid in different animal models of epilepsy. ( Löscher, W; Marescaux, C; Nau, H; Vergnes, M, 1984)
"Using mobile long-term electroencephalographic (EEG) monitoring in 7 absence epilepsy patients, the course of spike-wave discharge rate before and during valproate monotherapy was measured and compared to the profile of valproic acid serum level."3.67Lack of significant correlation between circadian profiles of valproic acid serum levels and epileptiform electroencephalographic activity. ( Burr, W; Froescher, W; Hoffmann, F; Stefan, H, 1984)
"A total of 64 problem patients with epilepsy (42 retrospective evaluations, 22 prospective cases) was treated with the combination of carbamazepine and valproic acid."3.67[Combination therapy with carbamazepine and valproic acid in problem cases at an outpatient epilepsy clinic]. ( Fröscher, W; Hoffmann, F; Stoll, KD, 1984)
"A method of measuring carbamazepine-10,11-epoxide (CBZ-10,11-EPOX) has been developed and used to monitor plasma concentrations in children suffering from various forms of epilepsy."3.67Altered ratio of carbamazepine-10,11-epoxide/carbamazepine in plasma of children: evidence of anticonvulsant drug interaction. ( Brett, EM; Elyas, AA; Lascelles, PT; Schoeman, JF, 1984)
"Ninety children with epilepsy were treated with carbamazepine (CBZ) alone or with other anticonvulsant drugs."3.67Correlation between plasma carbamazepine-10,11-epoxide concentration and drug side-effects in children with epilepsy. ( Brett, EM; Elyas, AA; Lascelles, PT; Schoeman, JF, 1984)
"A 20-month-old boy with absence epilepsy was found to have a strikingly elevated serum alkaline phosphatase (AP) at start of treatment with valproic acid."3.67Dynamic aspects in transient hyperphosphatasaemia of infancy. ( Carstensen, H; Rasmussen, KT, 1988)
"We have identified ten children who developed gastritis after prolonged anticonvulsant therapy that included either valproic acid or divalproex sodium."3.67Gastritis with valproate therapy. ( Bobele, GB; Bodensteiner, JB; Grunow, JE; Hille, MR; Marks, WA; Morris, MP; Tuggle, D, 1988)
"Fetal exposure to valproic acid has recently been associated with an increased incidence of neural tube defects."3.67Prenatal detection of a neural tube defect after fetal exposure to valproic acid. ( Campbell, WA; Cassidy, SB; Ciarleglio, L; Nochimson, DJ; Vintzileos, AM; Weinbaum, PJ, 1986)
"We studied 85 pediatric patients with different types of epilepsy treated with valproic acid."3.67Valproic acid in the treatment of epilepsy during the pediatric age. ( Olmos-Garcia de Alba, G; Valdez, JM, 1986)
"The association of fetal and neonatal distress, birth measurements, major malformations, and minor anomalies was studied prospectively in 14 infants of women with epilepsy who were receiving valproic acid (VPA) monotherapy and in 12 infants of women with epilepsy who were receiving VPA in combination with other anticonvulsant drugs."3.67Fetal growth, major malformations, and minor anomalies in infants born to women receiving valproic acid. ( Deichl, A; Hartmann, AM; Helge, H; Jäger-Roman, E; Jakob, S; Koch, S; Nau, H; Rating, D; Steldinger, R, 1986)
"Three drugs which increase GABA-mediated inhibitory neurotransmission in the brain, namely the GABA degradation inhibitors aminooxyacetic acid (AOAA) and gamma-acetylenic GABA (GAG), and the GABA receptor agonist THIP (gaboxadol), were administered to epilepsy-prone gerbils via subcutaneously implanted osmotic minipumps for 2 weeks."3.67Development of tolerance to the anticonvulsant effect of GABAmimetic drugs in genetically epilepsy-prone gerbils. ( Löscher, W, 1986)
"In six patients with epilepsy and fibrocystic breast disease the concentration in serum of antiepileptic drugs was obtained before, during, and after danazol therapy."3.67Clinically significant danazol-carbamazepine interaction. ( Haidukewych, D; Lichten, EM; Zielinski, JJ, 1987)
"To assess the most efficient means of monitoring thyroid status in an epilepsy clinic, total thyroxine (T4), free thyroxine stimulating hormone (TSH) were measured in 71 adult patients treated long-term with either phenytoin (DPH), carbamazepine (CBZ) or sodium valproate (VAL)."3.67The effective evaluation of thyroid status in patients on phenytoin, carbamazepine or sodium valproate attending an epilepsy clinic. ( Borsey, DQ; Browning, MC; Connacher, AA; Davidson, DL; Jung, RT, 1987)
"In a survey of the red cell folate status of 200 patients with epilepsy, compared to 72 controls, we found that median red cell folate levels were reduced significantly in patients treated with phenytoin (p less than 0."3.67A comparative study of the relative effects of anticonvulsant drugs and dietary folate on the red cell folate status of patients with epilepsy. ( Baker, M; Bissessar, A; Callaghan, N; Crowley, M; Goggin, T; Gough, H, 1987)
"Neural tube, craniofacial, and other congenital abnormalities have been described in infants born to mothers with epilepsy who were treated with valproic acid (VPA) during pregnancy."3.67Congenital abnormalities in two sibs exposed to valproic acid in utero. ( Anderson, L; Chitayat, D; Farrell, K; Hall, JG, 1988)
"The Comprehensive Epilepsy Program of Minnesota database was searched for patients who had no dose change of carbamazepine (CBZ), phenytoin (PHT) or valproate (VPA) for 3 consecutive visits."3.67Variability of phenytoin, carbamazepine and valproate concentrations in a clinic population. ( Leppik, IE, 1988)
"After treatment with valproic acid a 19-year-old female patient with Friedreich's ataxia and generalised epilepsy died following acute hepatic failure with massive lactacidosis."3.67[Acute liver necrosis caused by valproate]. ( Hackenberg, K; Rengeling, M; Rühl, G; Zäh, W, 1985)
"The EEGs of 16 newly diagnosed children with primary generalized epilepsy were examined before and during up to 3 years of antiepileptic therapy with valproic acid."3.67Spectral analysis of the EEG in children during the introduction of antiepileptic therapy with valproic acid. ( Benninger, C; Matthis, P; Scheffner, D, 1985)
"The purpose of the follow-up study was to determine whether modern therapy with ethosuximide and/or valproate with/without phenobarbitone and its derivatives improves the longterm prognosis of absence epilepsy as compared to formerly used treatments."3.67Longterm follow-up of childhood epilepsy with absences. I. Epilepsy with absences at onset. ( Baier, WK; Dieterich, E; Doose, H; Fichsel, H; Tuxhorn, I, 1985)
"A total of 20 children with various types of epilepsy were treated with valproate, 11 with monotherapy and 9 with valproate in combination with phenobarbitone, phenytoin, or carbamazepine."3.66Plasma concentrations of valproate during maintenance therapy in epileptic children. ( Boréus, LO; Lundberg, B; Nergårdh, A, 1982)
" The present study comprised 31 patients with newly diagnosed epilepsy, commencing treatment with either carbamazepine or valproate."3.66Serum thyroid hormones and blood folic acid during monotherapy with carbamazepine or valproate. A controlled study. ( Bentsen, KD; Gram, L; Veje, A, 1983)
"The problem of phenytoin-induced gingival hyperplasia is dicussed within the context of consultative planning between oral care practitioners and the physician managing the epilepsy."3.66Therapeutic alternatives in phenytoin-induced gingival hyperplasia. A case report and discussion. ( Kirkham, DB; Reynolds, NC, 1980)
"Two patients treated with valproic acid developed stomatitis, which was not dose-related and cleared promptly after the drug was stopped."3.66Valproate-induced stomatitis. ( Russo, LS, 1981)
"Sodium valproate is often used with phenytoin when epilepsy cannot be controlled by a single drug."3.66Phenytoin-valproate interaction: importance of saliva monitoring in epilepsy. ( Hamshaw-Thomas, A; Knott, C; Reynolds, F, 1982)
"In 12 institutionalized epilepsy patients who had been treated 19 months (SD +/- 5) with valproic acid, 27."3.66Serial free and plasma valproic acid and phenytoin monitoring and drug interactions. ( Haidukewych, D; Rodin, EA, 1981)
"Valproic acid (VPA) was determined by EMIT assay in plasma, tears, saliva, and cerebrospinal fluid (CSF) of patients with epilepsy."3.66The free fraction of valproic acid in tears, saliva, and cerebrospinal fluid. ( Mastropaolo, C; Monaco, F; Mutani, R; Piredda, S; Tondi, M, 1982)
"During the course of a prospective serial study over a period of one year, findings compatible with immune-mediated thrombocytolysis accompanied the administration of valproic acid in about half of 45 children with epilepsy."3.66Valproic acid and immune thrombocytopenia. ( Barr, RD; Copeland, SA; Kelton, JC; Morris, N; Stockwell, ML, 1982)
"The authors studied antipyrine disposition before and after delivery in 4 epileptic women whose anticonvulsant plasma level per dosage ratio was lowered during pregnancy, and compared the results to those found in nonpregnant women undergoing antiepileptic treatment (N = 6) and healthy women (N = 6)."3.66Antipyrine disposition in relation to lowered anticonvulsant plasma level during pregnancy. ( Chiba, K; Ishizaki, T; Nakazawa, Y; Tabuchi, T; Wagatsuma, T, 1982)
"The side effects and possible side effects of the therapy with valproic acid were documented in 66 outpatients with epilepsy over a period of one year."3.66[Antiepileptic therapy with valproinic acid. Correlations of side effects and serum levels of valproinic acid]. ( Fröscher, W; Gugler, R; Schulz, HU, 1979)
"Sodium valproate and ethosuximide are anticonvulsants employed in the treatment of petit mal epilepsy; both drugs are considered to be thalamically active."3.66Effects of valproate and ethosuximide on thalamocortical excitability. ( Englander, RN; Hanna, GR; Johnson, RN; Nowack, WJ, 1979)
"Of 88 patients with intractable epilepsy, 60 have been treated with clonazepam for up to three years and 60 have been treated with sodium valproate for up to 18 months."3.65Sodium valproate and clonazepam in the treatment of intractable epilepsy. ( Anthony, M; Lance, JW, 1977)
" VPM summary of product characteristics and pharmacokinetic studies revealed a lower bioavailability (80% vs."3.01Valproate, divalproex, valpromide: Are the differences in indications justified? ( Besson, VC; Blaise, N; Bloch, V; Chouchana, M; Delage, C; Etain, B; Hagenimana, M; Palayer, M; Smati, J, 2023)
"Epilepsy is the most common symptom in patients with brain tumors."3.01Epilepsy and brain tumors: Two sides of the same coin. ( Aronica, E; Ciusani, E; Coppola, A; Costa, C; Maschio, M; Perversi, F; Russo, E; Salmaggi, A, 2023)
"The classification of seizure types and epilepsies should be examined before selecting the ASMs for each patient with epilepsy."3.01[Medical Treatment of Epilepsy]. ( Jin, K, 2023)
"Epilepsy is a group of neurological diseases characterized by susceptibility to recurrent seizures."3.01Management of epilepsy during pregnancy and lactation. ( Harris, KM; Hope, OA, 2023)
"The aims of the study were to develop a population pharmacokinetic model of orally administered brivaracetam in paediatric patients and to provide dosing suggestions."2.84Brivaracetam population pharmacokinetics in children with epilepsy aged 1 month to 16 years. ( Schoemaker, R; Stockis, A; Wade, JR, 2017)
"This study reviewed all published valproic acid (VPA) population pharmacokinetic (PPK) models in adult patients and assessed them using external validation methods to determine predictive performance."2.82Published population pharmacokinetic models of valproic acid in adult patients: a systematic review and external validation in a Chinese sample of inpatients with bipolar disorder. ( de Leon, J; Dong, F; Guo, W; Li, AN; Ruan, CJ; Zang, YN, 2022)
"Carbamazepine and phenytoin were the drugs most strongly associated with decreases in T4 and T3 levels while topiramate had the greatest elevating effect on TSH."2.82Side effects of long-term oral anti-seizure drugs on thyroid hormones in patients with epilepsy: a systematic review and network meta-analysis. ( Cai, M; Guo, X; Han, Y; Lin, W; Yang, J; Zhong, R, 2022)
"The phenytoin treatment causes cerebellar defect and anemia."2.82The interplay of epilepsy with impaired mitophagy and autophagy linked dementia (MAD): A review of therapeutic approaches. ( Agrawal, M; Dhurandhar, Y; Panda, SP, 2022)
"Although generalized convulsive status epilepticus (GCSE) is a life-threatening emergency, evidence-based data to guide initial drug treatment choices are lacking in the Chinese population."2.82Phenobarbital Versus Valproate for Generalized Convulsive Status Epilepticus in Adults: A Prospective Randomized Controlled Trial in China. ( Chen, W; Chun, B; Gao, D; Jiang, M; Liu, G; Ren, G; Su, Y; Tian, F; Ye, H; Zhang, Y, 2016)
"The LTG population pharmacokinetic model developed in this study may be a reliable method for individualising the LTG dosing regimen in paediatric and young adult patients on combination therapy during therapeutic drug monitoring."2.79Pharmacokinetics of lamotrigine in paediatric and young adult epileptic patients--nonlinear mixed effects modelling approach. ( Brzaković, B; Kovačević, SV; Martinović, Ž; Miljković, B; Pokrajac, M; Prostran, M; Vučićević, K, 2014)
" The validity of this approach remains uncertain and could be improved by understanding sources of pharmacokinetic variability."2.77Population pharmacokinetics of valproic acid in pediatric patients with epilepsy: considerations for dosing spinal muscular atrophy patients. ( Barrett, JS; Jayaraman, B; Swoboda, KJ; Williams, JH, 2012)
"Carbamazepine is a widely used anticonvulsive agent."2.76Effects of carbamazepine and metabolites on IL-2, IL-5, IL-6, IL-10 and IFN-γ secretion in epileptic patients: the influence of co-medication. ( Breton, H; Demoly, P; Gelisse, P; Hillaire-Buys, D; Mathieu, O; Picot, MC, 2011)
"No patient in the VPA group developed respiratory depression, hypotension, or hepatic dysfunction, whereas in the DZP group, 5."2.76Valproate versus diazepam for generalized convulsive status epilepticus: a pilot study. ( Chen, WB; Fan, CQ; Gao, R; Ren, Y; Su, YY; Wang, L; Zhang, YZ; Zhao, JW, 2011)
"Fifty-two patients with epilepsy of generalized seizures type were randomly divided into an ACCWM group (n=30) and a WM group (n=22)."2.76[Observation on therapeutic effect of acupoint catgut-embedding combined western medicine for epilepsy of generalized seizures type]. ( Gao, ZG; Mao, ZN; Wang, SB; Zhang, GW, 2011)
"To assess changes in seizure frequency, medication side-effects (especially tremor) and formulation preference after switching patients overnight from immediate-release to extended-release divalproex sodium."2.74Seizure control and side-effect profile after switching adult epileptic patients from standard to extended-release divalproex sodium. ( Brannegan, RT; Evans, AT; Pierre-Louis, SJ, 2009)
" Only one adverse event was reported; a 9-year-old male experienced burning at the infusion site while receiving 660 mg intravenous valproate at 6 mg/kg per minute."2.73Safety of rapid intravenous valproate infusion in pediatric patients. ( Coots, BP; Morton, LD; O'Hara, KA; Pellock, JM, 2007)
"Rapid administration of undiluted valproate is safe and well tolerated at infusion rate up to 10 mg/kg/min and doses of up to 30 mg/kg."2.73Safety of rapid intravenous loading of valproate. ( Cofield, SS; Dutta, S; Faught, E; Knowlton, RK; Limdi, NA; Paige, AL; Ver Hoef, LW, 2007)
"Valproic acid is a widely used anticonvulsant drug with a broad therapeutic spectrum."2.73Inhibitory effect of valproic acid on cytochrome P450 2C9 activity in epilepsy patients. ( Babaoglu, MO; Bilir, E; Bozkurt, A; Gunes, A; Yasar, U; Zengil, H, 2007)
"The onset of epilepsy is most prevalent between 1 and 3 years of age; however, approximately 25% of patients developed epilepsy before one year of age."2.72Epilepsy in Angelman syndrome: A scoping review. ( Samanta, D, 2021)
"We systematically reviewed the existing literature on the cosmetic adverse effects of antiseizure medications (ASMs) in order to depict a clear picture of these unwanted side effects of ASMs with a particular attention to hair loss, hirsutism, acne, and gingival hyperplasia."2.72Cosmetic adverse effects of antiseizure medications; A systematic review. ( Asadi-Pooya, AA; Mirzaei Damabi, N; Rostaminejad, M; Zeraatpisheh, Z, 2021)
" The DFL for divalproex-ER dosed as a q12h regimen was 22% less than that for once-daily divalproex-ER (P=0."2.72Every-12-hour administration of extended-release divalproex in patients with epilepsy: impact on plasma valproic acid concentrations. ( Cavanaugh, JH; Dutta, S; Granneman, GR; Locke, C; Reed, RC, 2006)
"The goal of our study was to evaluate clinical and serum valproic acid concentration changes in patients following overnight conversion from delayed-release sodium valproate (VPA-DR) to the same daily dosage of extended-release sodium valproate (VPA-ER)."2.72Conversion from delayed-release sodium valproate to extended-release sodium valproate: initial results and long-term follow-up. ( Lehman, EB; McCabe, PH; McNew, CD; Michel, NC, 2006)
" The aims of our study were to evaluate whether color vision and macular function are impaired in epileptic adolescents, to study if the monotherapy with valproic acid (VPA) and carbamazepine (CBZ) can affect color vision and macular function and to determine the possible relationship between color vision, retinal function and antiepileptic drugs (AEDs) dosage and their serum concentrations."2.72Color vision and macular recovery time in epileptic adolescents treated with valproate and carbamazepine. ( Chiarelli, F; Gallenga, PE; Iannetti, P; Lobefalo, L; Spalice, A; Tocco, AM; Verrotti, A, 2006)
" Similar proportions of subjects in the two groups reported adverse events during or within 6 h following the first infusion."2.71Safety and tolerance of rapidly infused Depacon. A randomized trial in subjects with epilepsy. ( Cantrell, D; Cloyd, JC; Collins, SD; Naritoku, DK; Ramsay, RE; Sommerville, K; Walch, JK, 2003)
"The availability of an intravenous formulation now makes possible rapid administration of valproate (VPA) loading doses, but estimates of key VPA pharmacokinetic parameters in patients have limited the use of this approach."2.71Valproate unbound fraction and distribution volume following rapid infusions in patients with epilepsy. ( Cao, G; Cloyd, JC; Collins, SD; Dutta, S; Granneman, GR; Walch, JK, 2003)
" Patients were converted during an 2.71Lamotrigine monotherapy compared with carbamazepine, phenytoin, or valproate monotherapy in patients with epilepsy. ( Hammer, AE; Kaminow, L; Schimschock, JR; Vuong, A, 2003)
" Reduction in VPA dosage in the third patient produced no improvement."2.71Reversible parkinsonism with normal beta-CIT-SPECT in patients exposed to sodium valproate. ( Clough, P; Duncan, S; Easterford, K; Fallon, K; Kellett, M, 2004)
" Pharmacokinetic parameters were determined by a noncompartmental method."2.71Topiramate pharmacokinetics in children with epilepsy aged from 6 months to 4 years. ( Bouhours, P; Chiron, C; d'Athis, P; Dulac, O; Echenne, B; Grinspan, A; Mikaeloff, Y; Pons, G; Rey, E; Soufflet, C; Vallée, L, 2004)
"The use of VPA in the treatment of epilepsy is not associated with visual field defects similar to vigabatrin, but may induce abnormalities in colour vision."2.71Visual function in epilepsy patients treated with initial valproate monotherapy. ( Kälviäinen, R; Mäntyjärvi, M; Rissanen, E; Sorri, I, 2005)
" We developed a simple dosing scheme using valproate sodium injection (VPA-IV) and divalproex sodium extended-release (VPA-ER) tablets to minimize the time required for initiation of therapy, without increasing the likelihood of seizures and adverse effects."2.71Successful initiation of combined therapy with valproate sodium injection and divalproex sodium extended-release tablets in the epilepsy monitoring unit. ( Boggs, JG; Preis, K, 2005)
"In an observational study under routine clinical setting data after administration of once daily evening dosing of valproate sustained release minitablets were recorded in 359 patients with epilepsy aged between 12 and 86 years."2.71[Valproate sustained release in the treatment of epilepsy]. ( Fraunberger, B; Stefan, H, 2005)
"Weight gain is a common side effect of valproate treatment."2.71Serum insulin, leptin, and neuropeptide y levels in epileptic children treated with valproate. ( Aydin, K; Bideci, A; Gucuyener, K; Okuyaz, C; Serdaroglu, A, 2005)
" The peak concentration (Cmax) of CZP and the time intervals from dosing to Cmax (Tmax) were 20."2.70Pharmacokinetic and pharmacodynamic effects of clonazepam in children with epilepsy treated with valproate: a preliminary study. ( Wang, L; Wang, XD, 2002)
"Valproic acid (VPA) is an effective antiepileptic drug (AED), which is associated with dose-related adverse reactions such as skin rash, hair loss (alopecia), etc."2.70Low serum biotinidase activity in children with valproic acid monotherapy. ( Karikas, GA; Regoutas, S; Schulpis, KH; Tjamouranis, J; Tsakiris, S, 2001)
"The present study evaluates effect of pharmacokinetic interaction between caffeine (300 mg) in three divided doses with sodium valproate (400 mg) and carbamazepine (200 mg) given as single doses, in normal human volunteers, using a open cross over design."2.69Influence of caffeine on pharmacokinetic profile of sodium valproate and carbamazepine in normal human volunteers. ( David, J; Joseph, T; Kulkarni, C; Vaz, J, 1998)
"The most important factor determining seizure recurrence was continued therapy, which was the case for barbiturates, phenytoin and valproate."2.69Does withdrawal of different antiepileptic drugs have different effects on seizure recurrence? Further results from the MRC Antiepileptic Drug Withdrawal Study. ( Chadwick, D, 1999)
" Two analyses of adverse events are presented: tolerability and safety."2.69Safety and tolerability of gabapentin as adjunctive therapy in a large, multicenter study. ( Bernstein, P; Faught, RE; Holmes, GL; Magnus-Miller, L; McLean, MJ; Morrell, MJ; Privitera, MD; Rose-Legatt, A; Willmore, LJ, 1999)
"To evaluate plasma homocysteine (Hcy) concentrations in children receiving sodium valproate (VPA) and carbamazepine (CBZ), monotherapy, in comparison with healthy control subjects and to determine the possible relationship between Hcy levels and dosage and plasma concentrations of the antiepileptic drugs."2.69Hyperhomocysteinemia in children treated with sodium valproate and carbamazepine. ( Chiarelli, F; Giuva, T; Morgese, G; Pascarella, R; Trotta, D; Verrotti, A, 2000)
" Adverse events, laboratory studies performed, and seizure activity were documented on case report forms."2.68Safety of intravenous valproate. ( Dean, C; Devinsky, O; Gates, J; Leppik, I; Pellock, JM; Ramsay, RE; Willmore, LJ, 1995)
"Lamotrigine was effective in all seizure types examined, particularly for typical and atypical absence seizures."2.68Lamotrigine for the treatment of epilepsy in childhood. ( Alving, J; Besag, FM; Dulac, O; Hosking, G; Spencer, SC; Wallace, SJ, 1995)
" Furthermore, we sought to evaluate whether a relationship existed between VPA dosage and plasma clearance for both total and unbound or free drug."2.68Relationship between valproic acid dosage, plasma concentration and clearance in adult monotherapy patients with epilepsy. ( Gidal, BE; Maly, MM; Pitterle, ME; Spencer, NW, 1995)
" The median elimination half-life (t1/2) in patients receiving concomitant valproate (VPA) was 43."2.68Pharmacokinetic interactions between lamotrigine and other antiepileptic drugs in children with intractable epilepsy. ( Boreus, L; Eriksson, AS; Hoppu, K; Nergårdh, A, 1996)
"Lamotrigine (LTG) is a new antiepileptic drug (AED), chemically unrelated to the drugs in current use."2.68Serum concentrations of lamotrigine in epileptic patients: the influence of dose and comedication. ( Jürgens, U; May, TW; Rambeck, B, 1996)
"The steady-state pharmacokinetics of valproate (VPA) and topiramate (TPM) were compared during VPA monotherapy, concomitant VPA and TPM therapy, and TPM monotherapy to evaluate pharmacokinetic interactions."2.68Comparison of the steady-state pharmacokinetics of topiramate and valproate in patients with epilepsy during monotherapy and concomitant therapy. ( Anderson, G; Kramer, LD; Levy, RH; Liao, S; Nayak, RK; Palmer, M; Rosenfeld, WE, 1997)
" The mean area under the concentration-time curve, peak concentration and pre-dose concentration of VPA were unchanged by remacemide hydrochloride in three patients on the higher and in 10 patients on the lower dose of remacemide."2.68Lack of pharmacokinetic interaction between remacemide hydrochloride and sodium valproate in epileptic patients. ( Brodie, MJ; Girvan, J; Jamieson, V; Jones, T; Leach, JP; Richens, A, 1997)
"On treatment with carbamazepine (n = 27) and phenytoin (n = 8), the excretion of alpha 1-microglobulin was significantly increased, as compared with the healthy controls."2.67Renal tubular dysfunction following treatment with anti-epileptic drugs. ( Korinthenberg, R; Wehrle, L; Zimmerhackl, LB, 1994)
" Median AUCs of CBZ, VPA and PHT during a dosage interval did not differ significantly after treatment with OXC and placebo."2.67A double-blind, placebo-controlled interaction study between oxcarbazepine and carbamazepine, sodium valproate and phenytoin in epileptic patients. ( Blacklaw, J; Brodie, MJ; Connelly, D; Forrest, G; Gillham, RA; McKee, PJ; Walker, SM, 1994)
" The Cmax and Tmax values of the test formulation were significantly different from the values of the reference in single-(Tmax: 158."2.67Pharmacokinetic comparison of two valproic acid formulations--a plain and a controlled release enteric-coated tablets. ( Chong, WS; Jang, IJ; Lee, KH; Lee, N; Myung, HJ; Rha, JH; Shin, SG, 1993)
" Valproate plasma levels and performances in attention and vigilance tasks were monitored during a 12-h period (daytime), both during monotherapy of conventional valproate (VPA) and 4 weeks after switching to a similar dosage of VPA-CR taken once daily."2.67Conventional and controlled release valproate in children with epilepsy: a cross-over study comparing plasma levels and cognitive performances. ( Bakker, AM; Brouwer, OF; Edelbroek, PM; Jennekens-Schinkel, A; Lanser, JB; Peters, AC; Pieters, MS; Stijnen, T; van Geel, AA, 1992)
" The extent of absorption from sprinkle equaled that from syrup (relative bioavailability = 1."2.67Comparison of sprinkle versus syrup formulations of valproate for bioavailability, tolerance, and preference. ( Cloyd, JC; Jancik, JT; Jones-Saete, CM; Kriel, RL; Ong, BY; Remmel, RP, 1992)
"3."2.67Differential effects of valproic acid and enzyme-inducing anticonvulsants on nimodipine pharmacokinetics in epileptic patients. ( Baasch, H; Barzaghi, N; Caresia, L; Galimberti, CA; Gatti, G; Manni, R; Mück, W; Parietti, L; Tartara, A; Zucca, C, 1991)
" In 2009, a review was published providing guidance for the dosing and therapeutic drug monitoring of antiepileptic drugs during pregnancy."2.66Therapeutic Drug Monitoring of Antiepileptic Drugs in Women with Epilepsy Before, During, and After Pregnancy. ( Arfman, IJ; Lambrechts, DA; Ter Horst, PGJ; Touw, DJ; Wammes-van der Heijden, EA; Wegner, I, 2020)
"This narrative review aimed to provide critical findings of the available literature about the role of pharmacodynamic AEDs' interactions in patients whose epilepsies were treated with polytherapy."2.66Pharmacodynamic interactions of antiepileptic drugs: From bench to clinical practice. ( Brigo, F; Lattanzi, S; Verrotti, A; Zaccara, G, 2020)
"Valproic acid (VPA) is a remarkably safe and effective antiepileptic drug."2.66The changes of serum zinc, copper, and selenium levels in epileptic patients: a systematic review and meta-analysis. ( Boczek, T; Guo, F; He, Z; Hu, H; Jia, W; Kong, J; Shao, D; Song, Y; Tang, H; Wang, Y; Xia, L; Xu, X; Yang, L; Zhang, X, 2020)
"Epilepsy is one of the most common neurological complications in pregnancy; some women continue to use antiepileptic drugs (AEDs) to control seizures."2.66[Transfer Mechanisms of Compounds between Mother and Fetus/Infant Aimed for Optimized Medication during Pregnancy and Breastfeeding]. ( Furugen, A, 2020)
"Valproic acid (VPA) was the first recognized AED to cause disturbances potentially due to metabolic changes and increasing weight."2.66Reproductive health in patients with epilepsy. ( Chatzistefanidis, D; Georgiou, I; Keramida, A; Kyritsis, AP; Markoula, S; Siarava, E; Zikopoulos, A, 2020)
" At a mean daily dosage of less than 20 mg/kg, 83% of the patients became seizure-free."2.66Monotherapy with valproate in primary generalized epilepsies. ( Beaumanoir, A; Blajev, B; Bourgeois, B; de la Cruz, N; Despland, PA; Egli, M; Geudelin, B; Kaspar, U; Ketz, E; Kronauer, C, 1987)
" In the dosage used, l-tryptophan was tolerated well by these children, and seizure frequency, as a whole, remained unaltered."2.65l-Tryptophan in hyperactive child syndrome associated with epilepsy: a controlled study. ( Ghose, K, 1983)
"Phenytoin has been widely prescribed alone; our results indicate that sodium valproate may also be used as a single drug in the treatment of several types of epilepsy."2.65Comparison of sodium valproate and phenytoin as single drug treatment in epilepsy. ( Johnson, RH; Lambie, DG; Melville, ID; Nanda, RN; Shakir, RA, 1981)
" The early knowledge of pediatric patients' CYP2C9-status facilitates the optimization of valproate dosing which contributes to the avoidance of misdosing induced adverse reactions, such as abnormal blood levels of ammonia and alkaline phosphatase, and improves the safety of children's anticonvulsant therapy."2.61Relevance of CYP2C9 Function in Valproate Therapy. ( Bűdi, T; Csukly, G; Déri, M; Kiss, Á; Monostory, K; Nagy, A; Tóth, K, 2019)
"Valproic acid (VPA) is a commonly used antiepileptic drug (AED)."2.61Valproic acid and Stevens-Johnson syndrome: a systematic review of descriptive studies. ( Kashyap, A; Rashid, M; Undela, K, 2019)
"Carbamazepine (CBZ) was found to be effective in most cases."2.61Epilepsy in patients with EAST syndrome caused by mutation in the KCNJ10. ( Albaradie, R; Alhazmi, R; Alkhaldi, H; Chaudhary, M; Housawi, Y; Mir, A, 2019)
"Therefore, in children with a seizure disorder on long-term valproate therapy, 25-OH-Vit D levels should be monitored and appropriate supplementation implemented if levels are deficient."2.61Valproate decreases vitamin D levels in pediatric patients with epilepsy. ( Chen, F; Guo, H; Hu, Y; Jing, X; Li, G; Lu, XP; Sun, F; Sun, J; Wang, T; Wen, X; Xu, Z, 2019)
"Epilepsy is a common neurological condition with a worldwide prevalence of around 1%."2.55Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. ( Marson, AG; Nevitt, SJ; Sudell, M; Tudur Smith, C; Weston, J, 2017)
"Epilepsy is a common neurological condition with a worldwide prevalence of around 1%."2.55Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. ( Marson, AG; Nevitt, SJ; Sudell, M; Tudur Smith, C; Weston, J, 2017)
" If only valproate therapy owns the ability to obtain seizure freedom, then stopping its administration is not suggested, but a low dosage has to be aimed (500-600 mg/day, but not more than 1000 mg/day): according to some studies, most idiopathic generalized epilepsies can be controlled by low valproate dosage."2.55[Valproate in the treatment of epilepsy and status epilepticus]. ( Bóné, B; Janszky, J; Tényi, D, 2017)
"Reflex epileptic seizures can often be prevented by avoidance or modification of triggers or by prophylactic benzodiazepine administration."2.53Reflex epileptic mechanisms in ictogenesis and therapeutic consequences. ( Guaranha, M; Lin, K; Wolf, P, 2016)
"Individually, childhood epilepsy and migraine are two of the most common conditions seen in pediatric neurology."2.50Migraine and epilepsy in the pediatric population. ( Kossoff, EH; Oakley, CB, 2014)
"For patients with migraine, the pregnancy labeling of VPA will be changed from Category "D" to "X."2.50Risks of neurobehavioral teratogenicity associated with prenatal exposure to valproate monotherapy: a systematic review with regulatory repercussions. ( Gentile, S, 2014)
"Full seizure control in the pre-pregnancy year, and adjusting antiepileptic drug doses to maintain plasma drug concentrations throughout pregnancy at values associated with seizure control before pregnancy, have major influences in preserving seizure control during pregnancy."2.50Treating epilepsy in pregnant women. ( Eadie, MJ, 2014)
"Epilepsy is one of the commonest chronic neurological disorders in developing countries."2.50[Epilepsy, antiepileptic drugs and disorders of reproductive functions of women]. ( Gregoraszczuk, EL; Grzyb, E; Kwiecińska, P, 2014)
"Seizures and intracranial hemorrhage are possible medical diseases that any obstetrician may encounter."2.49Seizures and intracranial hemorrhage. ( Alexander, JM; Wilson, KL, 2013)
"Drug-resistant epilepsy has remained a problem since the inception of antiepileptic drug development, despite the large variety of antiepileptic drugs available today."2.49The search for better epilepsy treatments: from slime mould to coconuts. ( Walker, MC; Williams, RS, 2013)
" Consequences of these pharmacokinetic (PK) properties may include adverse events (AEs) and breakthrough seizures, potentially leading to poor adherence."2.49Extended-release antiepileptic drugs: a comparison of pharmacokinetic parameters relative to original immediate-release formulations. ( Hovinga, CA; Leppik, IE, 2013)
" They responded well to the reduction in dosage or to withdrawal of the apparent causing agent."2.49[Medication-related oculogyric crises: a description of four cases and a review of the literature]. ( Campistol, J; Darling, A; Perez-Duenas, B; Poo, P, 2013)
"We report a case of Takotsubo syndrome after epilepsy, and review the literature."2.48Takotsubo syndrome (TKS): a possible mechanism of sudden unexplained death in epilepsy (SUDEP). ( Dubuisson, N; Dupuis, F; Dupuis, M; Evrard, F; van Rijckevorsel, K; Van Robays, P, 2012)
"Acute seizure and status epilepticus constitute one of the major medical emergencies in children."2.48Management of acute seizure and status epilepticus in pediatric emergency. ( Sasidaran, K; Singhi, P; Singhi, S, 2012)
"54; strength of evidence: low) or adverse events (RR 0."2.48Efficacy and safety of innovator versus generic drugs in patients with epilepsy: a systematic review. ( Ashaye, A; Baker, EL; Baker, WL; Coleman, CI; Kluger, J; Phung, OP; Scholle, JM; Talati, R; White, CM, 2012)
"Phenobarbital was associated with a higher rate of drug withdrawal although there was no evidence to suggest that phenobarbital caused more adverse events compared to carbamazepine, valproic acid or phenytoin."2.47Side effects of phenobarbital in epilepsy: a systematic review. ( Li, YP; Zeng, LN; Zhang, LL, 2011)
"Pediatric epilepsy is a common, chronic, and challenging physical illness for children and their families."2.46Psychiatric concerns in pediatric epilepsy. ( Bujoreanu, IS; DeMaso, DR; Ibeziako, P, 2010)
"Studies on mechanisms of seizure generation and propagation have identified new potential targets for AEDs."2.45New antiepileptic drugs: molecular targets. ( Mula, M, 2009)
"Women with untreated epilepsy are more likely to have irregular menstrual cycles than are nonepileptic controls, indicating that the disease itself plays a role in the etiology of these reproductive abnormalities."2.44Menstrual cycle dysfunction associated with neurologic and psychiatric disorders: their treatment in adolescents. ( Hayes, FJ; Joffe, H, 2008)
" Measuring antiepileptic drug levels in body fluids (therapeutic drug monitoring) is frequently used to optimise drug dosage for individual patients."2.44Therapeutic monitoring of antiepileptic drugs for epilepsy. ( Dahl, ML; Kimland, E; Tomson, T, 2007)
"A rationale for their use in migraine prophylaxis is the hypothesis that migraine and epilepsy share several common pathogenetic mechanisms."2.44Antiepileptic drugs in migraine: from clinical aspects to cellular mechanisms. ( Calabresi, P; Cupini, LM; Galletti, F; Rossi, C; Sarchielli, P, 2007)
"Angelman syndrome is a neurogenetic disorder caused by lack of UBE3A gene expression from the maternally inherited chromosome 15 due to various 15q11-q13 abnormalities."2.44Epilepsy in Angelman syndrome. ( Boyd, SG; Cheron, G; Dan, B; Pelc, K, 2008)
"Phenytoin has been causally implicated in three human cancers: lymphoma, myeloma and neuroblastoma, the latter specifically in the setting of foetal hydantoin syndrome."2.43Cancer risk in people with epilepsy: the role of antiepileptic drugs. ( Driever, PH; Sander, JW; Singh, G, 2005)
"We report a 66-year-old man with hepatic encephalopathy due to a non-cirrhotic porto-systemic shunt during the course of treatment for epilepsy with sodium valproate."2.43[Successful balloon-occluded retrograde transvenous obliteration (B-RTO) in a case of symptomatic epilepsy with hepatic encephalopathy due to non-cirrhotic porto-systemic shunt]. ( Hayashi, S; Noguchi, M; Shibata, A, 2005)
"Successful long-term treatment of patients with epilepsy requires selection of an appropriate antiepileptic regimen, optimal dosing and patient compliance."2.43Progress in pharmaceutical development presentation with improved pharmacokinetics: a new formulation for valproate. ( Genton, P, 2005)
"When treatment with valproic acid is the most appropriate treatment to achieve optimal seizure control, a number of measures can be implemented to minimise risk to the fetus."2.43Valproic acid in epilepsy : pregnancy-related issues. ( Genton, P; Semah, F; Trinka, E, 2006)
" Oral forms are almost completely bioavailable but the rate of absorption varies between formulations."2.43Valproate as a mainstay of therapy for pediatric epilepsy. ( Guerrini, R, 2006)
"Epilepsy is a common medical problem and many studies have demonstrated that infants of women with epilepsy (WWE) have a two to threefold higher risk of congenital malformations compared with the background population."2.43Recent advances on neural tube defects with special reference to Valproic Acid. ( Chiarelli, F; Latini, G; Pelliccia, P; Tana, M; Verrotti, A, 2006)
"Agents introduced for the treatment of epilepsy have also been usedsimultaneously for psychiatric indications."2.43[Anticonvulsants treatment of psychiatric disorder in elderly patients]. ( Bidzan, L, 2006)
"Epilepsy was controlled with valproate at the age of 6 years."2.42A study of EEG and epilepsy profile in Wolf-Hirschhorn syndrome and considerations regarding its correlation with other chromosomal disorders. ( Fiore, LA; Freitas, A; Kim, CA; Valente, KD, 2003)
" If a dosage of AEDs in pregnant women with epilepsy is reduced to a reasonable minimum and the monotherapy is preferred, the risk of congenital malformations in their offspring can be minimized."2.42[Effect of anti-epileptic drugs on human placenta and the fetus]. ( Semczuk, M; Semczuk-Sikora, A, 2004)
" Valproate is available in different dosage forms for parenteral and oral use."2.41Pharmacological and therapeutic properties of valproate: a summary after 35 years of clinical experience. ( Perucca, E, 2002)
" The concepts of bioavailability and bioequivalence require further consideration."2.41Is generic prescribing acceptable in epilepsy? ( Besag, FM, 2000)
" However, on rare occasions, they can progress to more severe cutaneous disorders, including Stevens-Johnson syndrome and toxic epidermal necrolysis."2.41Therapeutic safety monitoring: what to look for and when to look for it. ( Harden, CL, 2000)
"Epilepsy affects 1."2.41New antiepileptic drugs and preparations. ( Jagoda, A; Yoon, Y, 2000)
"Neural tube defects were seen in 3% of the sample."2.41Valproic acid embryopathy: report of two siblings with further expansion of the phenotypic abnormalities and a review of the literature. ( Kozma, C, 2001)
"Minimal requirements: seizure-prevention outcome given as fraction of cases; AED or control assigned by random or quasi-random mechanism."2.41Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials. ( Temkin, NR, 2001)
" Rates of metabolism in children may be much faster than in nonelderly adults, requiring dosing adjustments to ensure enough medication is used to control seizures."2.41Treatment of epilepsy in 3 specialized populations. ( Leppik, IE, 2001)
"Fosphenytoin has recently been approved as a substitute for parenteral phenytoin."2.40New drug therapy for acute seizure management. ( Morton, LD; Pellock, JM; Rizkallah, E, 1997)
"Felbamate, however, has been linked with substantially increased incidence of aplastic anemia, and the other new AEDs have been studied for relatively short periods of time."2.40Pharmacologic and dietary therapies in epilepsy: conventional treatments and recent advances. ( Chapman, DP; Giles, WH, 1997)
"Lamotrigine is a phenyltriazine derivative with anticonvulsant properties that initially was tested in adults with partial seizures."2.40Adult experience with lamotrigine. ( Messenheimer, JA; Willmore, LJ, 1997)
" Because dosing is often modest, cost should rarely be the overriding factor in choosing a drug for a patient with newly diagnosed epilepsy in the developed world."2.40Monostars: an aid to choosing an antiepileptic drug as monotherapy. ( Brodie, MJ, 1999)
"Valproic acid is a branched-chained fatty acid, structurally unrelated to any other antiepileptic drug."2.39Valproic acid. A reappraisal of its pharmacological properties and clinical efficacy in epilepsy. ( Davis, R; McTavish, D; Peters, DH, 1994)
"Once epilepsy is diagnosed, long-term treatment with AEDs is recommended, beginning with monotherapy."2.39Standard approach to antiepileptic drug treatment in the United States. ( Pellock, JM, 1994)
" Particular attention has been paid to the role of age in determining the variability of pharmacokinetic parameters, but the effect of other factors, such as different formulations and routes of administration, concomitant treatments, gender and pathological conditions other than epilepsy, have also been considered."2.39Clinical pharmacokinetics of antiepileptic drugs in paediatric patients. Part I: Phenobarbital, primidone, valproic acid, ethosuximide and mesuximide. ( Avanzini, G; Battino, D; Estienne, M, 1995)
"Carnitine treatment does not always prevent the emergence of serious hepatotoxicity, but it does alleviate valproate-induced hyperammonemia."2.39Carnitine deficiency in epilepsy: Risk factors and treatment. ( Coulter, DL, 1995)
" TPM was added to the baseline antiepileptic drug (AED) at a dosage of up to 800 mg/day, after which the baseline drug was discontinued, when possible."2.39Drug interaction profile of topiramate. ( Bourgeois, BF, 1996)
" The usual phenytoin (PHT) dosage in adults is 4-6 mg/kg per day, but children may need a dosage three to five times higher."2.38Metabolism of antiepileptic medication: newborn to elderly. ( Leppik, IE, 1992)
"Epilepsy is a chronic disease that requires long term therapy, and most of the established antiepileptic drugs (the exception is phenobarbital) must be administered several times daily."2.38Pharmacokinetic evaluation of sustained release formulations of antiepileptic drugs. Clinical implications. ( Bialer, M, 1992)
"Rare, serious adverse effects of antiepileptic drugs (AEDs) include hepatotoxicity and bone marrow suppression."2.38Routine laboratory monitoring for serious adverse effects of antiepileptic medications: the controversy. ( Wyllie, E; Wyllie, R, 1991)
"Carnitine is an important nutrient that is present in the diet (particularly in meat and dairy products) and is synthesized from dietary amino acids."2.38Carnitine, valproate, and toxicity. ( Coulter, DL, 1991)
" Increasing the dosage raises the peak serum level and also increases the duration of time during which a minimum effective serum concentration is obtained."2.38The scope and use of valproate in epilepsy. ( Dean, JC; Penry, JK, 1989)
"Starting from Valproat dosage recommendations and serum levels and patient risk from acute hepatic failure, the results of our therapeutic service are set forth."2.38[Valproate dosage]. ( Meyer, FP; Walther, H, 1989)
"Valproic acid has probable teratogenic potential in humans but the number of reported cases is few and the spectrum of anomalies is broad so it is not possible to delineate a definite fetal valproate syndrome."2.37Congenital malformations associated with maternal use of valproic acid. ( Gauthier, M; Huot, C; Larbrisseau, A; Lebel, M, 1987)
"Among psychiatric disorders the acute symptoms of schizophrenia are exacerbated by enhanced GABA-ergic function."2.36Pharmacology of GABA. ( Meldrum, B, 1982)
" New antiepileptic drugs have improved medical management, and technical and theoretical advances in pharmacokinetics have permitted physicians to design balanced dosing for individual patients."2.36Recent developments in the diagnosis and therapy of epilepsy. ( Crandall, PH; Engel, J; Sterman, MB; Troupin, AS; Wasterlain, CG, 1982)
"Valproic acid is a new antiepileptic drug."2.36Valproic acid. Review of a new antiepileptic drug. ( Bruni, J; Wilder, BJ, 1979)
"Valproic acid has become a regular component of antiepileptic therapy."2.36[Valproic acid in the treatment of epilepsy with special emphasis on serum level determination (author's transl)]. ( Fröscher, W; Gugler, R; Schulz, HU, 1978)
" Using this fact we aimed to develop an MHD population pharmacokinetic (PPK) model in Chinese adult epileptic patients to facilitate the clinical implementation of model-guided individualised drug therapy."1.91Population pharmacokinetics of oxcarbazepine 10-monohydroxy derivative in Chinese adult epileptic patients. ( Dai, H; Hu, Y; Li, X; Yang, Q; Zhang, X, 2023)
"Forty patients (39."1.91Epilepsy and pregnancy. Factors associated with epileptic seizures during pregnancy. ( Barambio, S; Becerra, JL; Chíes, E; Ciurans, J; Codina, M; Fumanal, A; García-Esperón, C; Grau-López, L; Jiménez, M, 2023)
"PTZ gradually provoked seizure-related behaviors."1.91The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure. ( Abnous, K; Gorji Valokola, M; Heydari, FS; Mehri, S; Roohbakhsh, A, 2023)
"Nocturnal epilepsy is a neurological disease that has a significant effect on sleep."1.91Effect of valproate on sleep patterns disturbed by epilepsy. ( Ayala-Guerrero, F; Castro-Domínguez, D; Gutiérrez-Chávez, CA; Mateos-Salgado, EL; Mexicano-Medina, G, 2023)
"Epilepsy is characterized by the manifestation of spontaneous and recurrent seizures."1.91The Effect of Adenosine Signaling on Memory Impairment Induced by Pentylenetetrazole in Zebrafish. ( Bertoncello, KT; Bonan, CD, 2023)
"This study was undertaken to determine the impact of dosage in new users of lamotrigine (LTG) and the concomitant intake of valproic acid (VPA) on epidermal necrolysis (EN)."1.91Effects of dosage in new users of lamotrigine inducing epidermal necrolysis: Results of the German Registry of Severe Skin Reactions. ( Diederich, S; Hemmeter, U; Mockenhaupt, M; Paulmann, M, 2023)
"Familial adult myoclonus epilepsy (FAME) is a genetic condition characterized by the occurrence of cortical tremor, myoclonus, and epilepsy."1.91Current treatment options for familial adult myoclonus epilepsy. ( Bilo, L; Carreno, M; Coppola, A; Cuccurullo, C; Dubbioso, R; Hirsch, E; Licchetta, L, 2023)
"Epilepsy is a common chronic neurological disorder in the pediatric population and its evolution can be fatal."1.91Survey on the management of childhood epilepsy among general practitioners in the area of Marrakech. ( Bourrous, M; Gyamfi, SO; Lahmini, W, 2023)
"We present two cases of arginase deficiency with genetically confirmed ARG1 mutation in one and biochemical confirmation in both."1.91Arginase deficiency-An unheralded cause of developmental epileptic encephalopathy. ( Banerjee, M; Fasaludeen, A; Jose, M; Menon, RN; Pavuluri, H; Radhakrishnan, A; Sundaram, S, 2023)
"Studies have reported a recurrence rate ranging from 21%-50%, but most have included patients with different etiologies, electroencephalography (EEG) findings, and seizure types."1.91Risk of recurrence in patients with an unprovoked tonic-clonic seizure and generalized epileptiform discharges on EEG. ( Beaini, S; Beydoun, A; Hmeimess, G; Hotait, M; Jomaa, N; Nasreddine, W; Wazne, J, 2023)
" Therefore, knowledge about the typical adverse events (AEs) for ASMs and other coadministered drugs (CDs) is essential for practitioners and patients."1.91Adverse Event Profiles of Antiseizure Medications and the Impact of Coadministration on Drug Tolerability in Adults with Epilepsy. ( Knake, S; Kovac, S; Rosenow, F; Strzelczyk, A; van der Goten, M; von Podewils, F; Willems, LM; Zöllner, JP, 2023)
"Comorbid diagnosis of headache predicted use of topiramate and VPA, bipolar disease predicted use of LMT and VPA, pain predicted gabapentin, and schizophrenia was associated with VPAs use."1.91Prescribing Trends of Antiseizure Drugs in Women Veterans With Epilepsy. ( Amuan, ME; Henion, A; Lopez, MR; Panahi, S; Pugh, MJ; VanCott, AC, 2023)
"Period of pregnancy was calculated based on birth information in claims data."1.91Prescribing of valproate and oral antiepileptics for women of childbearing age and during pregnancy in Germany between 2010 and 2020. ( Köster, I; Meyer, I; Scholz, K; Schubert, I; Selke, GW, 2023)
" We should collaborate with obstetricians and other professionals to help ensure a safe environment for pregnancy and childbirth."1.91[Safe and Effective Management of Epilepsy in Pregnancy]. ( Iwasaki, M; Kimura, Y, 2023)
"The seizures were refractory to most anti-epileptic drugs but showed some response to Valproic acid."1.91Potassium Channel Subfamily T Member 1(KCNT1) Pathological Variant Causing Epilepsy Of Infancy With Migrating Focal Seizures: A Case Report. ( Angez, M; Chand, P; Hameed, AN; Kirmani, S, 2023)
"97%), switching to or adjusting carbamazepine dosage (27."1.91The impact of a newly established specialized pediatric epilepsy center in Tanzania: An observational study. ( Aricò, M; Di Noia, SP; Kalolo, A; Mabusi, MS; Mastrangelo, M; Pisani, F, 2023)
"This is a type of VPA-related encephalopathy, different from dose-dependent toxic encephalopathy, hyperammonaemic encephalopathy or encephalopathy related to liver failure."1.91Cerebral and cerebellar pseudoatrophy associated with valproic acid. Report of three pediatric cases. ( Arias-Vivas, E; Duat-Rodríguez, A; García-Peñas, JJ; González-Alguacil, E; Gutiérrez-Delicado, E; Heppe-Montero, M; Justel-Rodríguez, M; Ordoño-Saiz, MV; Púa-Torrejón, RC; Ruiz-Falcó-Rojas, ML; Soto-Insuga, V, 2023)
"Epilepsy is characterized by repeated seizure activity."1.91Impact of ( Kesavan, R; Kumar, RR; Narayan, SK; Ramakrishnan, K; Shewade, D; Venkatraman, S, 2023)
"Stroke is the leading cause of epilepsy in the elderly, ahead of degenerative diseases, tumors and head injuries."1.91Post-stroke seizures: risk factors and management after ischemic stroke. ( Derbali, H; Mansour, M; Messelmani, M; Mrissa, N; Mrissa, R; Ouerdiene, A; Zaouali, J, 2023)
"We examined 60 patients with genetic generalized epilepsy (GGE) aged 8-17 years."1.72Evaluation of optical coherence tomography findings in adolescents with genetic generalized epilepsy. ( Kaplan, AT; Oskan Yalcın, S; Sager, SG, 2022)
" We investigated potential transgenerational adverse effects of valproate."1.72Transgenerational adverse effects of valproate? A patient report from 90 affected families. ( Bewley, S; Braillon, A; Hill, C; MacLennan, AH; Martin, M, 2022)
"Epilepsy is a chronic neurological disease that affects more than 50 million people worldwide."1.72Effects of Low- and High-Dose Valproic Acid and Lamotrigine on the Heart in Female Rats. ( Ateş, B; Çolakoğlu, N; Parlakpınar, H; Vardı, N; Yıldız, A, 2022)
"Gabapentin was the most common second- and third-line ASM."1.72Antiseizure medication treatment pathways for US Medicare beneficiaries with newly treated epilepsy. ( Burke, JF; Choi, H; Terman, SW; Youngerman, BE, 2022)
"Valproate (VPA) is an effective treatment for epilepsy and also used in bipolar disorder."1.72National compliance with UK wide guidelines for usage of valproate in women of childbearing potential. ( Eriksson, SH; Sisodiya, SM; Tittensor, P, 2022)
"Epilepsy is a chronic neurological disorder that is characterized by episodes of seizure."1.72Clinical Evaluation of Levetiracetam in the Treatment of Epilepsy. ( Guan, S; Liu, J; Qian, F; Wang, Y; Wu, H; Yang, J, 2022)
"Specific antiseizure medications (ASM) would improve the outcome in post-stroke epilepsy (PSE)."1.72Efficacy and safety of antiseizure medication in post-stroke epilepsy. ( Groppa, S; Klimpe, S; Sandner, K; Stuckrad-Barre, SV; Uphaus, T; Winter, Y, 2022)
"The most common cause of seizures is epilepsy."1.72[Prospects for the development of new prolonged forms of valproic acid derivatives for the relief of convulsive syndrome]. ( Bespalov, AY; Krasnov, KA; Melekhova, AS; Reinuk, VL; Zorina, VN, 2022)
"After several years without seizures, 24 out of 30 had a relapse, which was quickly stopped in 23 out of 30 patients."1.72[Epilepsy in Angelman syndrome]. ( Bobylova, MY; Glukhova, LY; Kuzmich, GV; Mukhin, KY; Pylayeva, OA, 2022)
"Results: Mild cognitive impairment - MCI was diagnosed in 4 patients (28."1.72HYPERAMMONAEMIA AND COGNITIVE IMPAIRMENT IN EPILEPSY PATIENTS TREATED WITH VALPROIC ACID - PRELIMINARY STUDY. ( Dutkiewicz, J; Pilut, D; Szczygieł-Pilut, EE; Zajączkowska-Dutkiewicz, A, 2022)
"People with epilepsy are at a higher risk of developing vascular disease."1.72Identification of factors associated with new-onset vascular disease in patients admitted for video-EEG monitoring: A longitudinal cohort study. ( Chen, Z; Kwan, P; Nicolo, JP; Nightscales, R; O'Brien, TJ, 2022)
"Planned pregnancy was the only independent factor significantly associated with decreased risk of adverse pregnancy outcomes (OR, 0."1.72Effects of antiepileptic drugs polytherapy on pregnancy outcomes in women with epilepsy: An observation study in northwest China. ( Jiang, W; Jiang, Y; Ma, L; Shi, X; Song, C; Wang, Y; Xia, L; Zhang, Y; Zhao, J, 2022)
"The switch between nonseizure and seizure states involves profound alterations in network excitability and synchrony."1.72Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks. ( D'gama, PP; Hoffshagen, HH; Hotz, AL; Jamali, A; Jurisch-Yaksi, N; Mutlu, AK; Myren-Svelstad, S; Neuhauss, SCF; Ophus, SS; Ostenrath, AM; Yaksi, E, 2022)
"While the proband attained seizure control with sodium valproate, his mother's seizures were not well controlled."1.72A heterozygous missense variant in the YWHAG gene causing developmental and epileptic encephalopathy 56 in a Chinese family. ( Feng, X; Li, F; Pan, H; Song, Z; Xue, J; Yang, C; Yi, Z; Zhang, Y, 2022)
"Valproic acid (VPA) is a broad spectrum anticonvulsant drug, which could be partially metabolised by cytochrome P450 (CYP) 2C9 and 2C19 enzymes."1.72Impact of CYP2C19 and CYP2C9 gene polymorphisms on sodium valproate plasma concentration in patients with epilepsy. ( Li, X; Liu, L; Mao, P; Song, C; Song, W; Zhang, Y, 2022)
"Valproic acid (VPA) is an antiepileptic drug, used for focal and generalized seizure."1.72The impact of valproic acid treatment on weight gain in pediatric patients with epilepsy. ( Battaglia, D; Blasi, V; DI Ruscio, F; Ferrara, P; Gatto, A, 2022)
"Epilepsy is the most common childhood neurological disorder in Nigeria."1.62Serum folate levels in children on long-term anti-seizure medication in a Nigerian tertiary center-Implications for practice and public health. ( Aronu, AE; Bisi-Onyemaechi, AI; Chikani, UN; Ojinnaka, NC; Uwaezuoke, NA, 2021)
"Over two-thirds of women/girls with intellectual disability (ID) may have treatment-resistant epilepsy that could benefit from VPA treatment."1.62Valproate prescribing practices for women with intellectual disability across Europe. ( Angus-Leppan, H; Banks, R; Courtenay, K; Murphy, E; Perera, B; Reuber, M; Shankar, R; Watkins, L, 2021)
"Epilepsy is a common chronic neurological condition characterized by recurrent seizures."1.62 ( Miyata-Nozaka, Y; Omar, H; Raymond, AA; Tan, HJ; Wong, SW; Zain, SM, 2021)
"Tremor is a common movement disorder that can be induced by medications, including valproate, which is used for the treatment of epilepsy."1.62Clinical and Kinematic Features of Valproate-Induced Tremor and Differences with Essential Tremor. ( Angelini, L; Berardelli, A; Bologna, M; Cannavacciuolo, A; Colella, D; De Biase, A; Di Bonaventura, C; Giallonardo, AT; Paparella, G, 2021)
"Logistic regression analysis showed that maternal age over 31 years, family histories of fetal malformation, and conception after assisted fertility treatment, and also dosage of valproate, carbamazepine, and topiramate, made statistically significant (P<0."1.62The contribution of non-drug factors to fetal malformation in anti-seizure-medication-treated pregnancy. ( Eadie, MJ; Graham, JE; Hitchcock, AA; Lander, CM; O'Brien, TJ; Vajda, FJE, 2021)
"Carbamazepine was the second most common drug followed by lamotrigine and valproic acid."1.62Post-stroke epilepsy and antiepileptic drug use in men and women. ( Linnér, L; Loikas, D; Sundström, A; von Euler, M; Wettermark, B, 2021)
"Clinical outcome was seizure control during the 6 months observation period."1.62Association of UGT1A6 gene polymorphism with clinical outcome in pediatric epileptic patients on sodium valproate monotherapy. ( Adiga, S; Adiga, U; Banawalikar, N; Kumari, S; Sharmila, KP; Shenoy, V; Shetty, P; Shetty, S, 2021)
"Epilepsy is one of the most frequent neurological disorders characterized by an enduring predisposition to generate epileptic seizures."1.62Histopathological and Biochemical Assessment of Neuroprotective Effects of Sodium Valproate and Lutein on the Pilocarpine Albino Rat Model of Epilepsy. ( Al-Rafiah, AR; Mehdar, KM, 2021)
"Furthermore, Aβ42, implicated in Alzheimer's disease, undergoes β-sheet to α-helix transition in presence of PIMT."1.56The role of isoaspartate in fibrillation and its prevention by Protein-L-isoaspartyl methyltransferase. ( Chakrabarti, P; Chatterjee, BK; Chatterjee, T; Das, G; Dhar, J; Ghosh, S, 2020)
"Nodding syndrome is a highly debilitating, generalized seizure disorder, affecting children in subregions of sub-Saharan Africa."1.56Dried Blood Microsampling-Based Therapeutic Drug Monitoring of Antiepileptic Drugs in Children With Nodding Syndrome and Epilepsy in Uganda and the Democratic Republic of the Congo. ( Colebunders, R; Delahaye, L; Hotterbeekx, A; Idro, R; Mandro, M; Ogwang, R; Stove, CP; Velghe, S, 2020)
"Even though Epilepsy is a significant clinical issue in ATP1A3 patients, only a minority of publications provide any information about patients' anti-epileptic treatment."1.56ATP1A3-related epilepsy: Report of seven cases and literature-based analysis of treatment response. ( Abicht, A; Biskup, S; Boonsimma, P; Borggraefe, I; Gasser, M; Ittiwut, C; Krenn, M; Kuersten, M; Milenkovic, I; Netbaramee, W; Roser, T; Shotelersuk, V; Srichomthomg, C; Suphapeetiporn, K; Tacke, M; von Stülpnagel, C; Wagner, M; Wechapinan, T; Zimprich, F, 2020)
"Five groups of each of 12 female rats were orally dosed daily for 8 weeks with either carbamazepine (CBZ) (60 mg/kg), eslicarbazepine (ESL) (80 mg/kg), valproic acid (VPA) (300 mg/kg), levetiracetam (LEV) (50 mg/kg) or saline (control (CTL))."1.56Effects of carbamazepine, eslicarbazepine, valproic acid and levetiracetam on bone microarchitecture in rats. ( Andersen, NB; Diemar, SS; Ding, M; Eiken, P; Ellegaard, M; Jørgensen, NR; Sejling, AS, 2020)
"Carbamazepine was ineffective, and seizures were exacerbated with levetiracetam (LEV)."1.56Improvement of epilepsy with lacosamide in a patient with ring chromosome 20 syndrome. ( Goji, A; Kagami, S; Mori, T; Tayama, T; Toda, Y, 2020)
"Valproic acid (VPA) was a classic antiepileptic drug for fifty years."1.56Influence of age and co-medication on the concentration and efficacy of valproic acid in Chinese epilepsy children. ( Hu, W; Li, Z; Wang, Y, 2020)
"Prepregnancy reduction in VPA dosage reduced the hazard of fetal malformations, whereas ceasing intake of the drug decreased the hazard to one similar to that which applies in the general population, but at a cost of decreased control of epileptic seizures during the pregnancies studied."1.56Pregnancy after valproate withdrawal-Fetal malformations and seizure control. ( Eadie, MJ; Graham, JE; Hitchcock, AA; Lander, CM; O'Brien, TJ; Vajda, FJE, 2020)
"Valproic acid (VPA) is a widely used antiepileptic drugs."1.56Autophagy associated with the efficacy of valproic acid in PTZ-induced epileptic rats. ( Hu, L; Li, Q; Li, X; Li, Y; Li, Z; Lu, J; Tao, J; Wang, G; Wang, Y, 2020)
" Both, the type I isobolographic analysis and the test of parallelism of dose-response effects of the ASDs were used so as to properly classify interaction among three ASDs, administered in a fixed ratio combination of 1:1:1."1.56Sub-additive (antagonistic) interaction of lacosamide with lamotrigine and valproate in the maximal electroshock-induced seizure model in mice: an isobolographic analysis. ( Bojar, H; Florek-Łuszczki, M; Karwan, S; Kondrat-Wróbel, M; Plewa, Z; Zagaja, M; Łuszczki, JJ, 2020)
" The aim was to use long-term TDM to investigate pharmacokinetic variability of ASMs in these patients."1.56Pharmacokinetic Variability During Long-Term Therapeutic Drug Monitoring of Valproate, Clobazam, and Levetiracetam in Patients With Dravet Syndrome. ( Bjørnvold, M; Burns, ML; Heger, K; Johannessen Landmark, C; Johannessen, SI; Lund, C; Sætre, E, 2020)
" This study investigated the effect of delayed or missed doses on the pharmacokinetics (PK) of valproic acid (VPA) in patients with epilepsy and established remedial dosing recommendations for nonadherent patients."1.56Remedial dosing recommendations for delayed or missed doses of valproic acid in patients with epilepsy based on Monte Carlo simulations. ( Ding, JJ; Jiao, Z; Wang, CY; Yu, EQ; Zhu, GX, 2020)
"Epilepsy is very difficult to treat and often involves the combination of two or more AEDs."1.56Antiepileptic combination therapy with Stevens-Johnson syndrome and toxic epidermal necrolysis: Analysis of a Japanese pharmacovigilance database. ( Hayashi, T; Noguchi, Y; Tachi, T; Takaoka, M; Teramachi, H, 2020)
"Metabolic syndrome was more frequent in patients with epilepsy compared with healthy participants (32."1.56Metabolic syndrome and obstructive sleep apnea syndrome among patients with epilepsy on monotherapy. ( Ataklı, D; Balçık, ZE; Baslo, SA; Öztürk, O; Söylemez, E, 2020)
" However, the free form of VPA is responsible for its pharmacologic and toxic effects, and the total and free concentrations are highly discordant because of VPA's highly protein bound and saturable binding characteristics."1.56Safety range of free valproic acid serum concentration in adult patients. ( Huang, SY; Kuo, CH; Tseng, YJ; Wang, CY; Wang, KC; Wu, CC, 2020)
"Levetiracetam has replaced sodium valproate as the most frequently prescribed ASM in pediatric patients."1.56Trends of anti-seizure medication use in pediatric patients in six cities in China from 2013 to 2018. ( Dai, H; Feng, J; Yu, L; Yu, Z, 2020)
"Valproic acid (VPA) is a widely used anti-epileptic drug (AED) of demonstrated efficacy."1.56Risk-benefit assessment of treatment of epileptic women of childbearing age with valproic acid. ( Baraldés-Rovira, M; Gallego, Y; Mauri-Capdevila, G; Purroy, F; Quílez, A; Sanahuja, J, 2020)
" A dose-response relationship was demonstrated and the risk of NDs was more particularly increased for an exposure to VPA during the second or third trimesters of pregnancy."1.56Risk of early neurodevelopmental disorders associated with in utero exposure to valproate and other antiepileptic drugs: a nationwide cohort study in France. ( Blotiere, PO; Coste, J; Dray-Spira, R; Mikaeloff, Y; Miranda, S; Peyre, H; Ramus, F; Weill, A; Zureik, M, 2020)
"To study the risk of intellectual disability and delayed development in childhood milestones among children of women who used valproate or other AEDs during pregnancy."1.56Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Intellectual Disability and Delayed Childhood Milestones. ( Christensen, J; Daugaard, CA; Dreier, JW; Pedersen, L; Sun, Y, 2020)
"Valproic acid was less frequently prescribed to female patients."1.56Observational multicentre study into the use of antiepileptic drugs in Spanish neurology consultations. ( Campos Blanco, DM; Castro Vilanova, MD; López Gonzalez, FJ; Mercadé Cerdá, JM; Querol Pascual, MR; Serrano Castro, P, 2020)
"Epilepsy was present in 29."1.51[Epilepsy in children with congenital hemiparesis secondary to perinatal ictus]. ( Alonso, X; Campistol, J; Escofet, C; Fons, C; Macaya, A; Revilla Orías, MD, 2019)
"Severe hyponatremia was defined as a serum sodium level < 130 mEq/L."1.51Prevalence and risk factors for hyponatremia in adult epilepsy patients: Large-scale cross-sectional cohort study. ( Imai, K; Inoue, Y; Kagawa, Y; Ohta, A; Takahashi, Y; Yamamoto, Y, 2019)
"Epilepsy has a growing frequency, particularly in the elderly."1.51Cognitive performances in patients affected by late-onset epilepsy with unknown etiology: A 12-month follow-up study. ( Calabresi, P; Cesarini, EN; Costa, C; Di Santo, S; Farotti, L; Franchini, F; Izzi, F; Lanari, A; Liguori, C; Manfredi, N; Mercuri, NB; Parnetti, L; Placidi, F; Romoli, M; Salvadori, N; Spanetta, M, 2019)
"The predominant seizure types in NLLOE were focal to bilateral tonic-clonic seizures (30%) as well as focal onset impaired awareness motor seizures (IAMS) (22%) and focal onset impaired awareness nonmotor seizures (IANMS) (22%)."1.51Nonlesional late-onset epilepsy: Semiology, EEG, cerebrospinal fluid, and seizure outcome characteristics. ( Flöel, A; Hamann, L; Süße, M; von Podewils, F, 2019)
"Its use in pregnancy is associated with increased risks of congenital malformations and adverse neurodevelopment in the offspring and may be associated with an increased risk of attention-deficit/hyperactivity disorder (ADHD)."1.51Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Risk for Attention-Deficit/Hyperactivity Disorder in Offspring. ( Brikell, I; Christensen, J; Dalsgaard, S; Dreier, JW; Pedersen, L; Sun, Y, 2019)
"Epileptic seizures are frequent in patients with glioblastoma, and anticonvulsive treatment is often necessary."1.51AMPA receptor antagonist perampanel affects glioblastoma cell growth and glutamate release in vitro. ( Bergner, C; Hörnschemeyer, J; Kirschstein, T; Köhling, R; Krause, BJ; Lange, F; Linnebacher, M; Mullins, CS; Porath, K; Weßlau, K, 2019)
" The total CRST score was significantly associated with epilepsy duration and maximum VPA dosage (B = 0."1.51The clinical characteristics and related factors of tremor in patients with epilepsy. ( Chen, J; Jiang, X; Lu, L; Xiao, Y; Xiong, W; Zhang, Y; Zhou, D, 2019)
" Interestingly, regarding VPA dosage, we found that women taking equal or more than 700 mg/day of VPA have lower scores on empowerment in all dimensions compared with women with a VPA dosage lower than 700 mg/day."1.51Level of empowerment and decision-making style of women with epilepsy in childbirth age. ( Canevini, MP; Cutica, I; Pravettoni, G; Riva, S; Turner, K; Zambrelli, E, 2019)
"Carnitine levels were significantly low in patients under valproic acid therapy, however they were not found to be correlated with MDA, 8-OHdG or LFTs."1.51Effects of levetiracetam and valproic acid treatment on liver function tests, plasma free carnitine and lipid peroxidation in childhood epilepsies. ( Albayrak, P; Deda, G; Doğan, Ö; Eminoglu, FT; Haznedar, P; Öz Tunçer, G; Teber, S, 2019)
"Valproic acid (VPA) is a clinical medicine primarily prescribed to control epileptic symptoms."1.51Potential biomarker of fibroblast growth factor 21 in valproic acid-treated livers. ( Chen, J; Guo, C; Li, R; Liang, X; Xu, X, 2019)
"Focal epilepsy was diagnosed in 244 (69."1.51Why do some women with epilepsy use valproic acid despite current guidelines? A single-center cohort study. ( Bosak, M; Słowik, A; Turaj, W, 2019)
"Epilepsy is a common worldwide neurological disorder."1.51Self-reported attitudes about medication in Lebanese people with epilepsy. ( Al-Hajje, A; Boumediene, F; Jost, J; Mroueh, L; Preux, PM; Ratsimbazafy, V; Salameh, P, 2019)
"The intractable seizures showed complete but transient responsiveness to pyridoxal phosphate and finally controlled by valproate treatment."1.51ARX-associated infantile epileptic-dyskinetic encephalopathy with responsiveness to valproate for controlling seizures and reduced activity of muscle mitochondrial complex IV. ( Chu, VL; Fung, CW; Kwong, AK; Rodenburg, RJT; Smeitink, J, 2019)
"However, seizures are not typical and the majority of them were seizure-free."1.51A 16q22.2-q23.1 deletion identified in a male infant with West syndrome. ( Goji, A; Imoto, I; Ito, H; Kagami, S; Kohmoto, T; Mori, K; Mori, T; Toda, Y, 2019)
"The aims of this study were to develop a population pharmacokinetic (PPK) model of lamotrigine (LTG) in Chinese epileptic children by using nonlinear mixed effects modeling (NONMEM) and to investigate the effects of valproic acid (VPA) and genetic polymorphisms of the major metabolizing enzymes (UGT1A4, UGT2B7) on the pharmacokinetics of LTG."1.48Population pharmacokinetics of lamotrigine co-administered with valproic acid in Chinese epileptic children using nonlinear mixed effects modeling. ( Chen, Y; Liu, L; Liu, M; Liu, S; Lu, T; Wang, H; Xu, S; Zhao, L; Zhao, M, 2018)
"Curcumin is a phytochemical with promising effects on epilepsy treatment."1.48Micronization potentiates curcumin's anti-seizure effect and brings an important advance in epilepsy treatment. ( Aguiar, GPS; Bertoncello, KT; Oliveira, JV; Siebel, AM, 2018)
"Lamotrigine was the most frequently initiated drug in psychiatry, in both boys and girls."1.48Utilization of Antiepileptic Medicines in Swedish Children and Adolescents with Different Diagnoses. ( Karlsson Lind, L; von Euler, M; Wettermark, B; Wide, K, 2018)
"Levetiracetam was the most frequently prescribed AED (62/124, 50%)."1.48Safety of antiepileptic drugs in children and young people: A prospective cohort study. ( Choonara, I; Egunsola, O; Sammons, HM; Whitehouse, WP, 2018)
" The purpose of this study was to characterise pharmacokinetic variability of VPA in pregnancy, and discuss use of therapeutic drug monitoring (TDM) as guidance to exposure in women."1.48Pharmacokinetic variability of valproate during pregnancy - Implications for the use of therapeutic drug monitoring. ( Baftiu, A; Burns, ML; Farmen, AH; Johannessen Landmark, C; Johannessen, SI; Lossius, MI; Tomson, T, 2018)
"Hyperammonemic encephalopathy secondary to the use of valproate is rare without evidence of hepatotoxicity, and it usually presents with confusion, agitation, irritability, cognitive disturbances, lethargy, coma, and death."1.48Valproate-induced Hyperammonemic Encephalopathy Presenting as Catatonia. ( Espínola-Nadurille, M; Oñate-Cadena, N; Pérez-Esparza, R; Ramírez-Bermúdez, J, 2018)
"Carbamazepine was the most chosen antiepileptic drug for secondary prophylaxis, followed by valproate acid, and levetiracetam."1.48[A nationwide multi-center questionnaire survey on the management and treatment of post-stroke seizure and epilepsy in Japan]. ( Abe, S; Fukuma, K; Higashida, K; Ihara, M; Nagatsuka, K; Okuno, Y; Tanaka, T; Tomari, S; Toyoda, K; Yamagami, H, 2018)
"Although some drugs used in the treatment of epilepsy are known to affect body weight, the hormonal factors responsible have not been sufficiently described."1.48The effects of valproate and topiramate use on serum insulin, leptin, neuropeptide Y and ghrelin levels in epileptic children. ( Alver, A; Cansu, A; Çiçek, NP; Kamaşak, T; Okten, A; Serin, M, 2018)
"Evidence for the comparative teratogenic risk of antiepileptic drugs is insufficient, particularly in relation to the dosage used."1.48Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry. ( Battino, D; Bonizzoni, E; Craig, J; Lindhout, D; Perucca, E; Sabers, A; Thomas, SV; Tomson, T; Vajda, F, 2018)
"Individualised epilepsy care is the gold standard, not blanket bans on drug choice based on gender."1.48Valproate and epilepsy: for women as well as men. ( Lawthom, C, 2018)
"Valproic acid (VPA) is a first-line anti-epileptic drug that is used in the treatment of generalized and partial seizures."1.48Population pharmacokinetics of valproic acid in epileptic children: Effects of clinical and genetic factors. ( Chen, Y; Guo, Y; Wang, Z; Xu, S; Zhao, L; Zhao, M, 2018)
" Therefore, this study aimed to establish a population pharmacokinetic (PPK) model of LTG in Chinese children with epilepsy and to comprehensively evaluate the effects of genetic variations in drug-metabolizing enzymes, transporters, and a transcriptional regulator on LTG pharmacokinetics."1.48A Population Pharmacokinetic-Pharmacogenetic Model of Lamotrigine in Chinese Children With Epilepsy. ( Chen, Y; Lu, T; Wang, H; Wang, Z; Xu, S; Zhao, L; Zhao, M, 2018)
" Clinical data on epilepsy, characteristics of VPA treatment, risk factors for VHT, laboratory data on liver and pancreas functions, and adverse effects were collected."1.48Variants p.Q1236H and p.E1143G in mitochondrial DNA polymerase gamma POLG1 are not associated with increased risk for valproate-induced hepatotoxicity or pancreatic toxicity: A retrospective cohort study of patients with epilepsy. ( Ansakorpi, H; Eriksson, K; Haapala, P; Haataja, L; Hinttala, R; Hynynen, J; Jyrkilä, A; Kälviäinen, R; Kärppä, M; Komulainen-Ebrahim, J; Lähdetie, J; Majamaa, K; Mäkitalo, A; Myllynen, P; Pokka, T; Pylvänen, L; Rantala, H; Sokka, A; Uusimaa, J; Vieira, P; Ylikotila, P, 2018)
"Background The impact of adverse events (AEs) of antiepileptic drugs (AEDs) have an impact on compliance and dropouts."1.48Antiepileptic drugs in migraine and epilepsy: Who is at increased risk of adverse events? ( Bedetti, C; Calabresi, P; Caproni, S; Corbelli, I; Costa, C; Cupini, LM; Eusebi, P; Romoli, M; Sarchielli, P; Siliquini, S, 2018)
" While the concentration of 4-ene-VPA was not suitable as an early warning index, the results provide clear theoretical guidance for the rational and safe clinical use of VPA."1.46Association of CYP2C9, CYP2A6, ACSM2A, and CPT1A gene polymorphisms with adverse effects of valproic acid in Chinese patients with epilepsy. ( Ma, HY; Pan, J; Wang, C; Wang, P; Yang, LP; Yang, X, 2017)
"Valproic acid (VPA) is a widely prescribed broad-spectrum antiepileptic drug."1.46Influence of age and co-medication on the steady-state pharmacokinetics of valproic acid in Tunisian patients with epilepsy. ( Atheymen, R; Ben Mahmoud, L; Ghozzi, H; Hakim, A; Sahnoun, Z; Zeghal, K, 2017)
"Valproic acid (VPA) is an effective antiepileptic drug and mood stabilizer."1.46Monitoring Protein-Unbound Valproic Acid Serum Concentrations in Clinical Practice. ( de Jong, K; de Maat, M; Essink, G; Klok, B; Stalpers-Konijnenburg, S; van Erp, N; van Luin, M; Wallenburg, E, 2017)
" The aim of the study was to conduct an in vivo evaluation of the relationship between treatments with synthetic cannabinoid arachidonyl-2'-chloroethylamide (ACEA) alone or in combination with valproic acid (VPA) and hippocampal neurogenesis in a mouse pilocarpine model of epilepsy."1.46A Long-Term Treatment with Arachidonyl-2'-Chloroethylamide Combined with Valproate Increases Neurogenesis in a Mouse Pilocarpine Model of Epilepsy. ( Andres-Mach, M; Dudra-Jastrzębska, M; Haratym, J; Haratym-Maj, A; Maj, M; Rola, R; Zagaja, M; Łuszczki, JJ, 2017)
"Valproic acid data were adequately described by a 1-compartment model."1.46Population Pharmacokinetics of Valproic Acid in Patients with Mania: Implication for Individualized Dosing Regimens. ( Methaneethorn, J, 2017)
"Valproic acid (VPA) has been widely used in Chinese patients after craniotomy."1.46Analysis of the Variables Influencing Valproic Acid Concentration in the Serum and Cerebrospinal Fluid of Chinese Patients After Craniotomy. ( Chen, W; Gao, W; Li, Z; Liu, G, 2017)
" The mean serum concentrations and the mean serum concentrations per weight per daily dose per bioavailability (F) of anti-epileptic drugs (AEDs) before and during the treatment were assessed."1.46Effect of ketogenic diet and other dietary therapies on anti-epileptic drug concentrations in patients with epilepsy. ( Chang, MJ; Heo, G; Kim, SH, 2017)
"New-onset stroke was seen in three cases (10%) of the control group and in two cases (6."1.46Clinical study on anti-epileptic drug with B vitamins for the treatment of epilepsy after stroke. ( Huang, HL; Wang, N; Xu, L; Yu, CY; Zhou, H, 2017)
"The purpose was to investigate pharmacokinetic variability of valproic acid (VPA) in women of childbearing age by therapeutic drug monitoring (TDM) data to elucidate the variable relationship between dose and serum concentrations with the ultimate aim of facilitating safer use of VPA."1.46Pharmacokinetic variability of valproate in women of childbearing age. ( Baftiu, A; Burns, ML; Farmen, AH; Johannessen Landmark, C; Johannessen, SI; Lossius, MI; Tomson, T, 2017)
" Serum levels of valproate were estimated using HPLC for pharmacokinetic study."1.46Pharmacokinetic and pharmacodynamic interaction of hydroalcoholic extract of Ocimum sanctum with valproate. ( Gupta, YK; Joshi, D; Kaleekal, T; Kumar, R; Sarangi, SC, 2017)
"Melatonin is an indolic hormone that regulates a plethora of functions ranging from the regulation of circadian rhythms and antioxidant properties to the induction and maintenance of tumor suppressor pathways."1.46Melatonin and Hippo Pathway: Is There Existing Cross-Talk? ( Blandino, G; Lo Sardo, F; Muti, P; Strano, S, 2017)
"Epilepsy is one of the most common neurological diseases in childhood and adolescence."1.46Effects of Carbamazepine and Valproate on Serum Aspartate Aminotransferase, Alanine Aminotransferase and Gamma - Glutamyltransferase in Children. ( Hadzagic-Catibusic, F; Hasanbegovic, E; Melunovic, M; Uzicanin, S; Zubcevic, S, 2017)
"• Valproic acid has a cumulative effect on inhibiting brain activity in epileptogenic regions."1.46Resting-state fMRI revealed different brain activities responding to valproic acid and levetiracetam in benign epilepsy with central-temporal spikes. ( Dante, M; Hu, Z; Li, K; Li, Q; Li, Z; Lu, G; Wu, H; Xu, Q; Yang, F; Zhang, Q; Zhang, Z, 2017)
"The number of seizure-free patients in the last 4 weeks was overall CBZ/VPA/LTG/LEV=60%/79%/67%/67%, for generalized epilepsy was CBZ/VPA/LTG/LEV=67%/89%/65%/94%, and for localization-related epilepsy was CBZ/VPA/LTG/LEV=59%/71%/67%/57%."1.46Efficacy and tolerability of anti-epileptic drugs-an internet study. ( Baker, G; Wieshmann, UC, 2017)
"Valproic acid (VPA) was the most prescribed single therapy in young patients (<15years), whereas carbamazepine (CBZ) was preferred by clinicians in older patients."1.46Effectiveness and tolerability of antiepileptic drugs in 104 girls with Rett syndrome. ( Canevini, MP; La Briola, F; Nowbut, MS; Peron, A; Savini, MN; Turner, K; Vignoli, A, 2017)
" The UHPLC-MS/MS method demonstrated a good analytical performance essential for therapeutic drug monitoring, which would potentially lead to clinically relevant improvements in VPA dosage and patient management."1.46Simultaneous Determination of Valproic Acid and Its Major Metabolites by UHPLC-MS/MS in Chinese Patients: Application to Therapeutic Drug Monitoring. ( Li, G; Qiu, F; Sun, Y; Zhang, T; Zhao, L; Zhao, M, 2017)
"Sulforaphane (SFN) is a thiol compound found in wide abundance in cruciferous plants that has numerous reported therapeutic efficacies."1.46Sulforaphane protects against sodium valproate-induced acute liver injury. ( Atef, H; El-Khouly, OA; Nazmy, EA; Said, E, 2017)
"Valproic acid (VPA) is a widely used antiepileptic drug (AED)."1.46Drug interaction between valproic acid and carbapenems in patients with epileptic seizures. ( Chen, NC; Chen, SD; Chuang, YC; Hsiao, SC; Huang, CR; Lin, CH; Lu, YT; Tsai, WC, 2017)
"Epilepsy is a kind of neurogenic diseases with high prevalence and characterized by seizure, brain paradoxical discharge and convulsion in spontaneous, transient, recurrent and uncontrolled manner."1.43[Establish and use of an epilepsy model in larval zebrafish]. ( Song, DQ; Tang, S; Zhang, JP; Zheng, YM, 2016)
"A treatment with valproic acid was started, obtaining control of the neurological disease."1.43Recurrent seizures during acute acquired toxoplasmosis in an immunocompetent traveller returning from Africa. ( Bassetti, M; Beltrame, A; Buonfrate, D; Crichiutti, G; Meroni, V; Venturini, S, 2016)
"Epilepsy is an independent prognostic factor for longer survival in glioblastoma patients."1.43Prognostic relevance of epilepsy at presentation in glioblastoma patients. ( Berendsen, S; Bours, V; Broekman, ML; Kauw, F; Kroonen, J; Poulet, C; Robe, PA; Seute, T; Snijders, TJ; Spliet, WG; Varkila, M; Willems, M, 2016)
"Levetiracetam was independently associated with anger/aggression, nervousness/agitation, upset stomach, depression, and sleep disturbance; lamotrigine with nervousness/agitation, upset stomach, and difficulty concentrating; and valproic acid with upset stomach and shaky hands."1.43Specific adverse effects of antiepileptic drugs--A true-to-life monotherapy study. ( Fidzinski, P; Gaus, V; Holtkamp, M; Kowski, AB; Losch, F; Weissinger, F, 2016)
"Although Fanconi syndrome is rare in patients with epilepsy treated with sodium valproate (VPA), the prevalence might be higher in children with severe motor and intellectual disabilities (SMID)."1.43Outcome of renal proximal tubular dysfunction with Fanconi syndrome caused by sodium valproate. ( Sato, S; Watanabe, T; Yamazaki, S; Yoshikawa, H, 2016)
"Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy."1.43Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016)
" The correlation with dose may be a spurious finding related to the fact that physicians, in adjusting dosage according to clinical response, are more likely to use larger doses in patients with high clearance values."1.43An investigation of the influence of patient-related factors and comedications on lamotrigine clearance in patients with epilepsy. ( Alexandre, V; Baldoni, AO; de Santi Ferreira, FI; Freitas-Lima, P; Martinez, EZ; Pereira, LR; Perucca, E; Queiroz, RH; Sakamoto, AC, 2016)
" No correlation was found between duration or dosage of VPA and BMDs."1.43Bone health and vitamin D status in young epilepsy patients on valproate monotherapy. ( Albaghdadi, O; Alhalabi, MS; Alourfi, Z; Youssef, LA, 2016)
"Depression was evaluated in all experimental groups using tail suspension and forced swim test on days 1, 5, 10 and 15, 2h after pentylenetetrazole challenge."1.43Adjuvant indoleamine 2,3-dioxygenase enzyme inhibition for comprehensive management of epilepsy and comorbid depression. ( Goel, RK; Singh, T, 2016)
"The risk ratio for seizure increase on hormonal (18."1.43Differential impact of contraceptive methods on seizures varies by antiepileptic drug category: Findings of the Epilepsy Birth Control Registry. ( Cahill, KE; Fowler, KM; Hauser, WA; Herzog, AG; Mandle, HB, 2016)
"Valproic acid (VPA) is a broad-spectrum antiepileptic drug used for a variety of neurologic disorders."1.43Steady-state pharmacokinetic simulation of intermittent vs. continuous infusion valproic acid therapy in non-critically ill and critically ill patients. ( Cook, AM; Van Matre, ET, 2016)
" The dosage of PB was ranked first followed by that of CBZ and finally by the VPA."1.43[Therapeutic drug monitoring of three antiepileptic drugs - Back on twenty years of experience]. ( Badrane, N; Bencheikh, RS; Moussa, LA; Ouammi, L; Serragui, S; Tanani, DS; Zalagh, F, 2016)
"Carbamazepine-treated patients showed mean serum thyroid hormone levels significantly lower than baseline evaluation and the control group."1.42Evaluation of thyroid hormones in children receiving carbamazepine or valproate: a prospective study. ( Arapoglu, M; Dalgıç, N; Kafadar, İ; Kılıç, BA; Yalçın, K, 2015)
"There are several reports describing population pharmacokinetic (PPK) models of valproic acid (VPA)."1.42Population pharmacokinetics of valproic acid in adult Chinese epileptic patients and its application in an individualized dosage regimen. ( Guo, XZ; Huang, PF; Jiao, Z; Lin, WW; Liu, YW; Ma, CL; Wang, CL; Wang, HY, 2015)
" Our data suggest that valproate has adverse effects on renal tubular functions."1.42Does nephrotoxicity exist in pediatric epileptic patients on valproate or carbamazepine therapy? ( Buyan, N; Demir, E; Gücüyener, K; Gülbahar, Ö; Gürkaş, E; Havali, C; Serdaroğlu, A; Yılmaz, Ü, 2015)
"The present study aimed to establish population pharmacokinetic model for phenobarbital (PB), examining and quantifying the magnitude of PB interactions with other antiepileptic drugs concomitantly used and to demonstrate its use for individualization of PB dosing regimen in adult epileptic patients."1.42Nonlinear mixed effects modelling approach in investigating phenobarbital pharmacokinetic interactions in epileptic patients. ( Golubović, B; Jovanović, M; Kovačević, SV; Martinović, Ž; Miljković, B; Prostran, M; Vučićević, K, 2015)
"Valproic acid (VPA) follows a non-linear pharmacokinetic profile in terms of protein-binding saturation."1.42A population pharmacokinetic model of valproic acid in pediatric patients with epilepsy: a non-linear pharmacokinetic model based on protein-binding saturation. ( Ding, J; Jiao, Z; Li, X; Lin, W; Miao, L; Wang, C; Wang, Y; Zhao, L; Zhao, Z, 2015)
"Weight gain and alopecia were the most common patient-reported CSEs in this study, and weight gain was the most likely cosmetic side effect to result in dosage adjustment or medication discontinuation."1.42Cosmetic side effects of antiepileptic drugs in adults with epilepsy. ( Buchsbaum, R; Chen, B; Choi, H; Detyniecki, K; Hirsch, LJ; Javed, A; Kato, K; Legge, A; Moeller, J, 2015)
"Valproic acid treated animals were treated from 5 days preceding behavioral testing in the Morris water maze at a clinically relevant concentration."1.42Standard dose valproic acid does not cause additional cognitive impact in a rodent model of intractable epilepsy. ( Jellett, AP; Jenks, K; Lucas, M; Scott, RC, 2015)
"Valproic acid (VPA) is an antiepileptic drug that has been associated with impaired hemostasis and increased risk for postsurgical bleeding."1.42Effects of chronic administration of valproic acid to epileptic patients on coagulation tests and primary hemostasis. ( Canevini, MP; Cattaneo, M; Chiesa, V; Fontana, G; Lussana, F; Vignoli, A; Zighetti, ML, 2015)
"Secondary enuresis is a common adverse event associated with valproate use in children, which is not usually spontaneously reported and is reversible in most cases."1.42Valproate-induced enuresis: a prospective study. ( Arabi, M; Beydoun, A; Hmaimess, G; Makke, Y; Nasreddine, W; Sabbagh, S; Yamak, WR, 2015)
"Patients with Alzheimer's disease are at increased risk for unprovoked seizures and epilepsy compared with age-matched controls."1.42Reduction of epileptiform activity by valproic acid in a mouse model of Alzheimer's disease is not long-lasting after treatment discontinuation. ( Hiltunen, M; Pitkänen, A; Tanila, H; Viswanathan, J; Ziyatdinova, S, 2015)
" When the results of CYP2C9 genotyping and CYP2C9 expression were combined, the patients' VPA-metabolizing capacity was predicted, and VPA dosing was adjusted to the patients' CYP2C9-status."1.42Clinical significance of CYP2C9-status guided valproic acid therapy in children. ( Bűdi, T; Garami, M; Háfra, E; Kiss, Á; Monostory, K; Nagy, A; Szever, Z; Tapodi, A; Temesvári, M; Tóth, K, 2015)
"Valproic acid was prescribed most frequently as first and second treatment, followed by vigabatrin."1.42Epilepsy in children with tuberous sclerosis complex: Chance of remission and response to antiepileptic drugs. ( Bindels-de Heus, K; de Wit, MC; Moll, HA; Overwater, IE; Rietman, AB; Ten Hoopen, LW; Vergouwe, Y, 2015)
"Epilepsy is common in individuals with autism spectrum disorder (ASD) and intellectual disabilities (ID)."1.42Impact of epilepsy and antiepileptic medications on the metabolic profile in adults with autism spectrum disorder and intellectual disabilities. ( Katz, N; Moses, L; Weizman, A, 2015)
"Despite former publications no clear seizures could be reproduced but it was possible to establish focal EPs, which proved to be a reliable marker for epileptic activity."1.42Reduction of epileptiform activity through local valproate-implants in a rat neocortical epilepsy model. ( Altenmüller, DM; Feuerstein, TJ; Freiman, TM; Hebel, JM; Herrmann, LS; Rassner, MP; Volz, S, 2015)
"Multiple generalized seizures occurred in all homozygous mice around three weeks after birth."1.42Epileptogenesis and epileptic maturation in phosphorylation site-specific SNAP-25 mutant mice. ( Kataoka, M; Miyaoka, H; Otsuka, S; Saito, M; Suzuki, E; Takahashi, M; Watanabe, S; Yamamori, S, 2015)
"Oxcarbazepine was most widely used, followed by valproic acid."1.42Trends in Antiepileptic Drug Prescriptions for Childhood Epilepsy at a Tertiary Children's Hospital in Korea, 2001-2012. ( Ah, YM; Cho, YS; Jung, AH; Kim, KJ; Lee, JY, 2015)
" In this study, we developed a population-based pharmacokinetic (PK)-pharmacodynamic (PD) model to determine the optimal concentration of VPA according to the clinical characteristics of each patient."1.42Determination of the Optimal Concentration of Valproic Acid in Patients with Epilepsy: A Population Pharmacokinetic-Pharmacodynamic Analysis. ( Ishitsu, T; Matsuda, K; Nakagawa, K; Nakashima, H; Nishimura, M; Ogusu, N; Oniki, K; Ono, T; Saruwatari, J; Shimomasuda, M; Yasui-Furukori, N, 2015)
" Maternal levels and dosing information were used for estimating the maternal apparent oral clearance and the paired umbilical cord and maternal levels for estimation of umbilical cord/maternal level ratios."1.42Serum levels of valproic acid during delivery in mothers and in umbilical cord - correlation with birth length and weight. ( Brozmanova, H; Grundmann, M; Kacirova, I, 2015)
"VPA-induced encephalopathy is an uncommon but serious adverse effect that should be considered in patients with cognitive decline during VPA treatment."1.42[Valproate can induce reversible encephalopathy]. ( Christensen, J; Harbo, T; Prakash, S, 2015)
"To establish using dried blood spot (DBS) as a surrogate to plasma for therapeutic drug monitoring (TDM) of carbamazepine (CBZ), we compared the population pharmacokinetic (PPK) estimates from concurrent DBS and plasma levels."1.40Estimation and comparison of carbamazepine population pharmacokinetics using dried blood spot and plasma concentrations from people with epilepsy: the clinical implication. ( Chan, E; Ho, PC; Kong, ST; Lim, SH, 2014)
"The treatment profile for epilepsy, seizure control, and maternal and neonatal outcomes in both groups were compared using Chi-square test or Fisher's exact test and Mann-Whitney U test."1.40Impact of planning of pregnancy in women with epilepsy on seizure control during pregnancy and on maternal and neonatal outcomes. ( Abe, K; Hamada, H; Minakami, H; Obata-Yasuoka, M; Yamada, T; Yoshikawa, H, 2014)
"CNS inflammation is characterized by a disturbance of glial cell functions."1.40Glia and epilepsy: experimental investigation of antiepileptic drugs in an astroglia/microglia co-culture model of inflammation. ( Dambach, H; Faustmann, PM; Haase, CG; Hinkerohe, D; Hufnagel, A; Moinfar, Z; Prochnow, N; Stienen, MN, 2014)
"For patients with mental retardation or developmental delay, 25(OH)D3 levels were lower than the levels in patients with normal intelligence quotient levels (p=0."1.40Vitamin D levels in children and adolescents with antiepileptic drug treatment. ( Baek, JH; Eun, BL; Kim, GH; Kim, MK; Seo, YH, 2014)
"Levetiracetam treatment resulted in a decrease of the percentage of CD4(+)CD25(+)-lymphocytes (26."1.40Chronic valproate or levetiracetam treatment does not influence cytokine levels in humans. ( Bauer, S; Guenther, S; Hagge, M; Hamer, HM; Knake, S; Olmes, DG; Rosenow, F; Tackenberg, B, 2014)
" This type of protocol can be used to further evaluate AEDs and test effects of chronic administration of AEDs."1.40Effects of conventional anticonvulsant drugs on generalized tonic-clonic seizures in Noda epileptic rats. ( Inoue, M; Kaneko, Y; Naito, H; Noda, A; Yamamoto, A, 2014)
"73) in VPA-treated patients, but there were no associations with the VPA dosage or the homeostasis model assessment-estimated insulin resistance (HOMA-IR) index."1.40Comparison of the metabolic syndrome risk in valproate-treated patients with epilepsy and the general population in Estonia. ( Eglit, T; Haldre, S; Kõks, S; Lember, M; Rakitin, A, 2014)
"This retrospective study included 237 and 169 VPA-treated Japanese patients with epilepsy for population pharmacokinetic and pharmacokinetic-pharmacodynamic analyses, respectively."1.40Impact of the superoxide dismutase 2 Val16Ala polymorphism on the relationship between valproic acid exposure and elevation of γ-glutamyltransferase in patients with epilepsy: a population pharmacokinetic-pharmacodynamic analysis. ( Deguchi, M; Ishitsu, T; Kaneko, S; Nakagaswa, K; Nakashima, H; Nishimura, M; Noai, M; Ogusu, N; Oniki, K; Saruwatari, J; Yasui-Furukori, N, 2014)
"VPA-induced encephalopathy is an uncommon but serious adverse effect that should be considered in patients with cognitive decline during VPA treatment."1.40[Valproate can induce reversible encephalopathy]. ( Christensen, J; Harbo, T; Prakash, S, 2014)
" The symptoms of VHE were not correlated with the dosage and concentration of valproate."1.40[Clinical misdiagnosis analysis of valproate encephalopathy]. ( Chen, X; Su, Z; Wu, Z; Ye, S; Zhu, D; Zhuge, G, 2014)
"Hyperammonemia was defined as a plasma ammonia level exceeding 100 μg/dl with reference to the standard range and previous reports."1.39Risk factors for hyperammonemia in pediatric patients with epilepsy. ( Imai, K; Inoue, K; Inoue, Y; Itoh, K; Kagawa, Y; Mishima, N; Takahashi, Y; Yamamoto, Y; Yazawa, R, 2013)
"Valproate is used for the treatment of epilepsy and other neuropsychological disorders and may be the only treatment option for women of childbearing potential."1.39Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism. ( Christensen, J; Grønborg, TK; Parner, ET; Pedersen, LH; Schendel, D; Sørensen, MJ; Vestergaard, M, 2013)
" We report a 17-year-old man with epilepsy and Down's syndrome who experienced tremor during the treatment with a low dosage of sodium valproate."1.39Sodium valproate induced tremor in a patient with epilepsy and Down's syndrome. ( De Sarro, G; Gallelli, L; Loizzo, S; Russo, E; Siniscalchi, A; Tiziana, A, 2013)
"Early treatment of epilepsy is warranted to avoid possible severe consequences."1.39Epilepsy and brain injury: a case report of a dramatic neuropsychiatric vicious circle. ( Angeletti, G; Carbonetti, P; Del Casale, A; Fensore, C; Ferracuti, S; Girardi, P; Kotzalidis, GD; Lazanio, S; Muzi, A; Rapinesi, C; Savoja, V; Scatena, P; Serata, D; Tatarelli, R, 2013)
" The overall mean maternal valproate dosage taken by women in the Register decreased over the last 5 years of the study period."1.39Dose dependence of fetal malformations associated with valproate. ( Eadie, MJ; Graham, JE; Lander, CM; O'Brien, TJ; Vajda, FJ, 2013)
" The mean dosage of AED for valproate was 498 mg/day and carbamazepine was 555 mg/day."1.39Malformation in index pregnancy in women with epilepsy is not followed by recurrence in subsequent pregnancy. ( Begum, S; Sarma, SP; Thomas, SV, 2013)
"Epilepsy is one of the most common neurological diseases in the world."1.39[Valproic acid concentration in the blood serum of pregnant women and umbilical cord blood in relation to the condition of the newborn--case studies]. ( Breborowicz, GH; Chuchracki, M; Florek, E; Hassan-Bartz, M; Krzyścin, M; Kulza, M; Miller, R; Napierała, M; Wachowiak, A; Wozniak, A, 2013)
" In addition, there appeared to be a dose-response relationship between stroke risk and PHT prescriptions."1.39Comparative stroke risk of antiepileptic drugs in patients with epilepsy. ( Hsieh, CY; Lai, EC; Lin, SJ; Yang, YH, 2013)
"Depakote-induced hepatotoxicity has been well established as an adverse effect, and periodic monitoring of drug level is often required."1.38Thinking beyond the obvious: hepatotoxicity secondary to idiosyncratic depakote toxicity. ( Asadi, S; Avashia, KD; Chaudrey, KH; Ihsan, M; Irshad Khan, SI; Naser, TB; Nouri-Kolouri, M; Steinberg, A, 2012)
" Neurologists had progressively prescribed valproate less frequently and in lower dosage than other classes of practitioner over the 10-year study period, with a parallel decrease in occurrence of fetal malformations in pregnancies referred to the Register."1.38The prescribing of antiepileptic drugs for pregnant Australian women. ( Eadie, MJ; Graham, J; Hitchcock, AA; Hollingworth, S; Horgan, D; Lander, CM; O'Brien, TJ; Roten, A; Vajda, FJ, 2012)
"Valproic acid (VPA) is a major antiepileptic drug (AED) that is less potent than other AEDs."1.38Synthesis and anticonvulsant evaluation of dimethylethanolamine analogues of valproic acid and its tetramethylcyclopropyl analogue. ( Bialer, M; Shekh-Ahmad, T; Yavin, E, 2012)
"We aimed to determine cancer risk in people with epilepsy using sodium-valproate."1.38Cancer risk in people with epilepsy using valproate-sodium. ( Bell, GS; Driever, PH; Sander, JW; Singh, G, 2012)
"Epilepsy was confirmed by EEG and many seizures episodes were treated with different combination of anticonvulsive drugs."1.38[Epileptic asystole - a case report]. ( Bałajewicz, J; Bryniarski, L; Czamara, M; Jastrzębski, M; Kukla, P; Przyprawa, A, 2012)
"Phenytoin was used in 56 patients (22%) with the majority (n= 43) receiving intravenous phenytoin."1.38Seizure management at Auckland City Hospital Emergency Department between July and December 2009: time for a change? ( Bergin, P; Jones, P; Rosemergy, I; Walker, E, 2012)
"Epilepsy was induced by i."1.38Evaluation of the antiepileptic effect of curcumin and Nigella sativa oil in the pilocarpine model of epilepsy in comparison with valproate. ( Aboul Ezz, HS; Faraag, AR; Khadrawy, YA; Noor, NA, 2012)
" Moreover, a VPA dose-response curve was performed on PBMC obtained from healthy controls, demonstrating an increase of acetyl-histone H3 content."1.38Valproate induces epigenetic modifications in lymphomonocytes from epileptic patients. ( Conti, E; Difrancesco, JC; Ferrarese, C; Galimberti, G; Riva, C; Rodriguez-Menendez, V; Ruffmann, C; Tremolizzo, L, 2012)
"Individuals treated with combined valproate-lamotrigine rarely present late adverse effects (unrelated to introduction and titration)."1.38Late adverse effects of the coadministration of valproate and lamotrigine. ( Moreira, B; Thome-Souza, S; Valente, KD, 2012)
"Valproic acid was less effective in OHSCs than in the kindled seizure tests, and diazepam was more (generalized seizures) or less (focal seizures and afterdischarge durations) effective in this animal model than in OHSCs."1.38Primary afterdischarge in organotypic hippocampal slice cultures: effects of standard antiepileptic drugs. ( Albus, K; Heinemann, U; Wahab, A, 2012)
"He had been on a lamotrigine treatment due to epilepsy, and after cessation of lamotrigine, his cardiac enzyme levels returned to normal."1.38Lamotrigine related myocarditis: case report. ( Bayhan, T; Karagöz, T; Sahin, M; Yıldırım, I, 2012)
"We describe arginase deficiency in a 20-year-old woman with spastic paraplegia, progressive dystonia, dementia, peripheral neuropathy, epilepsy, liver cirrhosis, and non-B/non-C hepatocellular carcinoma."1.38Arginase deficiency with new phenotype and a novel mutation: contemporary summary. ( Ching, CK; Fung, CW; Lam, CW; Luk, HM; Mak, CM; Poon, WL; Siu, TS; Tam, S; Tsang, JP; Wong, VC, 2012)
"Phenobarbital has been in clinical use as an antiepileptic drug (AED) since 1912."1.38How did phenobarbital's chemical structure affect the development of subsequent antiepileptic drugs (AEDs)? ( Bialer, M, 2012)
" Pharmacokinetic parameters are necessary to predict the optimum therapeutic level after administration."1.37Pharmacokinetics and clinical application of intravenous valproate in Thai epileptic children. ( Bhudhisawadi, K; Chulavatnatol, S; Kaojareon, S; Vaewpanich, J; Visudtibhan, A, 2011)
"For unclassified epileptic seizures, no significant differences were found among the three AEDs."1.37Retrospective analysis of the effectiveness of first-line antiepileptic drugs for generalized onset and unclassified epileptic seizures in Chinese children. ( Ding, CH; Ding, YX; Fang, F; Ma, MS; Meng, LL; Wang, Y; Zou, LP, 2011)
" In the early phase of treatment, the main adverse effects included drowsiness, dizziness, and anorexia."1.37A 6-month prospective study on efficacy safety and QOL profiles of extended-release formulation of valproate in patients with epilepsy. ( Hong, Z; Li, T; Wang, B; Wu, XY; Xu, L; Yu, PM; Yue, L; Zhu, GX, 2011)
" These findings provide useful information to adjust the VPA dosage to achieve optimal therapeutic efficacy in epileptic infants."1.37Empirical approach for improved estimation of unbound serum concentrations of valproic acid in epileptic infants by considering their physical development. ( Aiba, T; Kurosaki, Y; Matsunaga, H; Ohtsuka, Y; Sato, T; Sendo, T; Ueshima, S, 2011)
"Two cohorts of patients with valproate-treated epilepsy and sex- and age-matched individuals (controls) from the general Danish population were identified by individual-level-linkage of nationwide registries and followed for 10 years."1.37Valproate attenuates the risk of myocardial infarction in patients with epilepsy: a nationwide cohort study. ( Abildstrøm, SZ; Andersson, C; Erdal, J; Gislason, GH; Hansen, PR; Olesen, JB; Schmiegelow, M; Torp-Pedersen, C; Weeke, P, 2011)
"The dominant patient was diagnosed with schizoaffective disorder and her non-dominant sister with paranoid schizophrenia."1.37Folie à deux: double case-report of shared delusions with a fatal outcome. ( Di Cosimo, D; Girardi, N; Kotzalidis, GD; Lazanio, S; Manfredi, G; Savoja, V; Talamo, A; Tatarelli, R; Vento, A, 2011)
"Approximately one third of newly treated epilepsy patients do not respond to antiepileptic drugs (AEDs)."1.37Lack of association of ABCB1 haplotypes on five loci with response to treatment in epilepsy. ( Haerian, BS; Lim, KS; Mohamed, EH; Mohamed, Z; Raymond, AA; Tan, CT; Tan, HJ; Wong, CP; Wong, SW, 2011)
"Curcumin was co-administered with sub-therapeutic dose of valproate 60min before PTZ injection."1.37Pharmacokinetic and pharmacodynamic interactions of valproate, phenytoin, phenobarbitone and carbamazepine with curcumin in experimental models of epilepsy in rats. ( Gupta, YK; Mehla, J; Pahuja, M; Reeta, KH, 2011)
"Valproic acid (VPA) is an anticonvulsant and mood-stabilizing drug for the long-term treatment."1.37Valproic Acid related metabolic syndrome in patients with epilepsy. ( Kasradze, S; Mania, M; Okujava, N, 2011)
" Plasma concentrations (pc), interactions between drugs in the ICU context, adverse effects and seizure occurrences were observed and recorded."1.37Levetiracetam compared to valproic acid: plasma concentration levels, adverse effects and interactions in aneurysmal subarachnoid hemorrhage. ( Bjeljac, M; Keller, E; Mink, S; Muroi, C; Seule, M, 2011)
"Treatment with curcumin, NSO or valproate ameliorated most of the changes induced by pilocarpine and restored Na⁺, K⁺-ATPase activity in the hippocampus to control levels."1.37The neuroprotective effect of curcumin and Nigella sativa oil against oxidative stress in the pilocarpine model of epilepsy: a comparison with valproate. ( Ezz, HS; Khadrawy, YA; Noor, NA, 2011)
"Epilepsy was confirmed in 58 cases."1.37[Epilepsy in elderly]. ( Kotov, AS; Rudakova, IG, 2011)
" To demonstrate a case of a 15 year old girl suffering from refractory epilepsy with underlying focal cortical dysplasia (FCD), whose seizure deterioration was most probably associated with drug-drug interactions between prescribed common antiepileptic drugs, namely valproic acid, phenobarbital or the prodrug primidon and carbamazepine."1.37Antiepleptic drug interactions: a clinical case demonstration. ( Klapková, E; Komárek, V; Tesfaye, H; Tesfayeová, A, 2011)
" These changes tended to parallel prescribing trends in the wider community, except for valproate, whose prescribing in the overall community increased as its prescribing, and its dosage prescribed, decreased in pregnancy."1.36Changing patterns of antiepileptic drug use in pregnant Australian women. ( Eadie, MJ; Graham, J; Hitchcock, AA; Hollingworth, S; Lander, CM; O'Brien, TJ; Vajda, FJ, 2010)
"Antiepileptic drugs (AEDs) have been widely used in patients with epilepsy but the adverse effects in adult Chinese patients have not been investigated."1.36Adverse effects of carbamazepine, phenytoin, valproate and lamotrigine monotherapy in epileptic adult Chinese patients. ( Wang, X; Xi, Z; Yan, Y; Zeng, K, 2010)
"To review our clinical experience and determine if there are appropriate signs and symptoms to consider POLG sequencing prior to valproic acid (VPA) dosing in patients with seizures."1.36POLG DNA testing as an emerging standard of care before instituting valproic acid therapy for pediatric seizure disorders. ( Bao, X; Koenig, MK; Lee, IC; Naviaux, RK; Saneto, RP; Weng, SW; Wong, LJ, 2010)
"Clonazepam was stopped."1.36Late-onset nocturnal intractable seizure during sleep: what is the origin? ( Liesiene, V; Miliauskas, S; Sakalauskas, R; Zemaitis, M, 2010)
"Weight gain was seen in 66."1.36Modification in body weight associated with antiepileptic drugs. ( Gaspari, CN; Guerreiro, CA, 2010)
"Epilepsy is one of the most frequent neurological diseases in the pediatric population."1.36[Characteristics of the children with epilepsy followed in the Marrakech University Hospital]. ( Amine, M; Bourrous, M; Bouskraoui, M; Draiss, G; Elibrahimi, I; Safini, F, 2010)
" Comparative pharmacokinetic analysis showed that α-Cl-TMCD is less susceptible to liver first-pass effect than α-F-TMCD because of lower total (metabolic) clearance and liver extraction ratio."1.36Comparative pharmacodynamic and pharmacokinetic analysis of two anticonvulsant halo derivatives of 2,2,3,3-tetramethylcyclopropanecarboxamide, an amide of a cyclic analog of valproic acid. ( Bialer, M; Finnell, RH; Hen, N; Kaufmann, D; Pessah, N; Wlodarczyk, B; Yagen, B, 2010)
"Epilepsy was diagnosed in 37% (375/1014) of the study participants."1.36Correlation between EEG abnormalities and symptoms of autism spectrum disorder (ASD). ( Yasuhara, A, 2010)
"Antiepileptic drugs (AED) as transplacental agents are known to have adverse effects on fetal development."1.36Transplacental genotoxicity of antiepileptic drugs: animal model and pilot study on mother/newborn cohort. ( Bakulic, TI; Demarin, V; Fucic, A; Gjergja, R; Jazbec, AM; Katic, J; Markovic, D; Miškov, S; Stojković, R; Zeljezic, D, 2010)
"The aim of the present study was to build population pharmacokinetic models for the clearance of valproate (VPA) in 2 separate populations of Serbian patients with epilepsy, children and adults."1.36Factors influencing valproate pharmacokinetics in children and adults. ( Jankovic, S; Jankovic, SM; Milovanovic, JR, 2010)
" Sodium valproate was administered at the dosage of 10-30 mg/kg/d."1.35[Influence of age, body weight and dose on sodium valproate plasma concentrations in children with epilepsy]. ( Jiang, Z; Liao, HM; Peng, QL; Tang, JW; Zhang, J, 2008)
"Valproic acid was the most frequently prescribed drug, followed by carbamazepine and lamotrigine."1.35Antiepileptic drug utilization in children from 1997-2005--a study from the Netherlands. ( Brouwer, OF; de Jong-van den Berg, LT; de Vries, TW; van de Vrie-Hoekstra, NW; van den Berg, PB, 2008)
"(2007) Seizure suppression by top1 mutations in Drosophila."1.35DNA topoisomerase I inhibitors ameliorate seizure-like behaviors and paralysis in a Drosophila model of epilepsy. ( Hormozi, L; Parker, L; Song, J; Tanouye, MA, 2008)
"Efficacy of seizure control was considered satisfactory if there was a reduction in seizures>50% or total control."1.35Association of lamotrigine and valproate in refractory epilepsies of children and adolescents. ( Antoniuk, SA; Bruck, I; Grisotto, KP; Santos, LH, 2008)
"Valproic acid (VPA) is a widely used and well-tolerable antiepileptic drug in epileptic patients."1.35The effects of biotin supplementation on serum and liver tissue biotinidase enzyme activity and alopecia in rats which were administrated to valproic acid. ( Akin, R; Arslan, M; Balamtekin, N; Kurt, I; Ozcan, O; Unay, B; Vurucu, S, 2009)
"Our findings suggest that hair loss in patients can be attributed to zinc and BA depletion within the first 3 months, and to zinc depletion only by the 6th month."1.35The influence of valproic acid treatment on hair and serum zinc levels and serum biotinidase activity. ( Paksu, MS; Tasdemir, HA; Yilmaz, Y, 2009)
"Early epilepsy is known to worsen the developmental prognosis of young children with a congenital focal brain lesion, but its direct role is often very difficult to delineate from the other variables."1.35The role of epilepsy in early language development in a child with a congenital lesion in the right hemisphere. ( Deonna, T; Maeder-Ingvar, M; Mayor-Dubois, C; Roulet-Perez, E, 2008)
"Total body weight, daily dose of valproate and concomitant therapy with PB are factors that significantly influence VPA kinetic disposition and they should be considered in programming dosage regimens for this antiepileptic drug in the pediatric population."1.35Population pharmacokinetics of valproate in Mexican children with epilepsy. ( Correa, T; Rodríguez, I; Romano, S, 2008)
"The purpose of this study was to perform population pharmacokinetic (PPK) analysis on carbamazepine and to determine the population model of clearance of this drug in terms of individual patient characteristics."1.35Pharmacokinetic modeling of carbamazepine based on clinical data from Serbian epileptic patients. ( Jankovic, SM; Jovanovic, D; Milovanovic, JR, 2008)
" These findings showed that with a much lower dosage of the drugs, which is suggested in texts can lead to an appropriate blood level of CBZ and VPA for controlling the epileptic seizures."1.35An experimental design for finding of minimum dosage of carbamazepine and valproate in preventing of seizure attacks. ( Nobahar, M; Samaei, A; Vafaei, AA, 2009)
"To characterize the interaction between tiagabine (TGB) and valproate (VPA)--two antiepileptic drugs in the mouse pentylenetetrazole (PTZ)-induced clonic seizure model, type I isobolographic analysis for non-parallel dose-response relationship curves (DRRCs) was used."1.35Interaction of tiagabine with valproate in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves. ( Krzyzanowski, M; Luszczki, JJ; Swiader, MJ, 2009)
"Epilepsy was most common among those with maternal deletions and unknown subtypes, with catastrophic epilepsies present in only these two subtypes."1.35Epilepsy in Angelman syndrome: a questionnaire-based assessment of the natural history and current treatment options. ( Braun, EK; Bruno, P; Conant, KD; Nespeca, MP; Said, RR; Thibert, RL; Thiele, EA, 2009)
"A total of 344 patients became seizure-free with the first prescribed antiepileptic drug."1.35Effectiveness of the first antiepileptic drug in the treatment of pediatric epilepsy. ( Ding, CH; Ding, YX; Fang, F; Ma, MS; Ying, W; Zou, LP, 2009)
"Epilepsy is often the most important clinical manifestation of the syndrome, even if its appearance is not constantly precocious."1.35Ring chromosome 20 syndrome: a link between epilepsy onset and neuropsychological impairment in three children. ( Canevini, MP; Dalla Bernardina, B; Darra, F; Fiorini, E; La Selva, L; Lazzarotto, F; Piazzini, A; Vignoli, A; Zucca, C, 2009)
" Limbic (psychomotor) seizure activity was evoked in albino Swiss mice by a current (32 mA, 6 Hz, 3s stimulus duration) delivered via ocular electrodes and isobolographic analysis for parallel and non-parallel dose-response effects was used to characterize the consequent anticonvulsant interactions between the various drug combinations."1.35Isobolographic characterization of interactions of levetiracetam with the various antiepileptic drugs in the mouse 6 Hz psychomotor seizure model. ( Luszczki, JJ; Patsalos, PN; Wlaz, A; Wojda, E, 2009)
"In this study 27 patients with focal or generalized epilepsy receiving a single dosage of prolonged-release valproate given in the evening were included."1.35Once daily monotherapy with prolonged-release valproate minitablets given in the evening--a chronopharmacological study. ( Fraunberger, B; Graf, W; Kerling, F; Pauli, E; Stefan, H; Yang, T, 2009)
" In patients with heterozygote (MTHFR) 677C/T polymorphism and under long-term use of certain drugs the determination of Hcy plasma levels may be useful to prevent the development of atherothrombotic disease."1.35Na VPA-induced acute ischemic stroke in an epileptic patient with methylenetetrahydrofolate reductase gene polymorphism. ( Varoglu, AO, 2009)
"To evaluate the effects of CYP2C19 and CYP2C9 genotypes on the pharmacokinetic variability of valproic acid (VPA) in epileptic patients using a population pharmacokinetic (PPK) approach."1.35Effects of CYP2C19 and CYP2C9 genotypes on pharmacokinetic variability of valproic acid in Chinese epileptic patients: nonlinear mixed-effect modeling. ( Bai, X; Jiang, D; Li, L; Lu, W; Müller, M; Wang, Y; Zhang, Q, 2009)
" We predict that excursions beyond the conventional recommended VPA plasma concentration range will commonly occur with high total mg daily doses (>or=2000 mg) of enteric-coated divalproex, if dosed once-daily, potentially producing clinical toxicity."1.35Once-daily dosing is appropriate for extended-release divalproex over a wide dose range, but not for enteric-coated, delayed-release divalproex: evidence via computer simulations and implications for epilepsy therapy. ( Dutta, S; Liu, W; Reed, RC, 2009)
" TDM requests, interpretation and dosage adjustment recommendations were mainly responsible by residents."1.35Effect of pharmacist participation in the health care team on therapeutic drug monitoring utilization for antiepileptic drugs. ( Faroongsarng, D; Kaewpibal, P; Ratanajamit, C; Setthawacharavanich, S, 2009)
"Epilepsy has been associated with poor obstetric outcomes that could be the result of the epilepsy itself or a direct effect of anti-epileptic medication on placentation."1.35Phenytoin but not valproate directly affected in vitro trophoblast differentiation. ( Anin, S; Bates, MD; Chadwick, D; Neilson, JP; Quenby, SM; Vince, GS, 2008)
"Visual auras are reported to be uncommon or rare in patients with idiopathic generalized epilepsy."1.35[Visual auras in idiopathic generalized epilepsy]. ( Coubes, P; Crespel, A; Gelisse, P, 2008)
"Epilepsy is a major public health problem affecting nearly 50 million people world wide."1.35Fish liver oil and propolis as protective natural products against the effect of the anti-epileptic drug valproate on immunological markers of bone formation in rats. ( El Elshamy, KA; Elwakkad, AS; Sibaii, H, 2008)
"The odds of having parkinsonism were 5 times higher with valproate than with other AEDs."1.34Movement disorders in patients taking anticonvulsants. ( Asante, AN; Carlen, P; Lang, A; Munhoz, RP; Politzer, N; Wennberg, R; Zadikoff, C, 2007)
"Epilepsy is one of the most common presentations of patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS)."1.34Valproic acid aggravates epilepsy due to MELAS in a patient with an A3243G mutation of mitochondrial DNA. ( Lin, CM; Thajeb, P, 2007)
"We diagnosed interstitial pneumonitis (IP) based on her chest CT and high serum concentrations of KL-6 and surfactant protein D."1.34[Valproate sodium and zonisamide associated interstitial pneumonitis in an infant]. ( Doi, T; Kato, T; Nikaido, K; Takayama, R, 2007)
" Relation could not be established between the duration of VPA therapy, dosage of the drug, blood level of drug, age and sex of the patients and the auditory signs."1.34Effects of valproic acid on hearing in epileptic patients. ( Akoglu, E; Duman, T; Incecik, F; Melek, I; Sangün, O, 2007)
" The pharmacokinetics of the 260 PB concentrations at a steady-state obtained from 79 patients was described with a one-compartment open pharmacokinetic model with first-order elimination."1.34Population estimation of the effects of cytochrome P450 2C9 and 2C19 polymorphisms on phenobarbital clearance in Japanese. ( Goto, S; Ishitsu, T; Murata, T; Nakada, N; Nakagawa, K; Seo, T; Ueda, N, 2007)
" No correlation was found between duration or dosage of treatment and BMI-SDS, height-SDS, or androgen level."1.34Endocrine effects of valproate in adolescent girls with epilepsy. ( de Vries, L; Goldberg-Stern, H; Karasik, A; Kiviti, S; Landau, Z; Phillip, M, 2007)
"Myo-inositol was found to be lower while taking VPA, although no relationship between the change in metabolite concentration, VPA dose or seizure control was observed."1.34The effect of sodium valproate on proton MRS visible neurochemical concentrations. ( Barker, GJ; Duncan, JS; McLean, MA; Simister, RJ, 2007)
"This means that seizures do not arise de novo in the seizure focus."1.34Temporal lobe epilepsy is a disease of faulty neuronal resonators rather than oscillators, and all seizures are provoked, usually by stress. ( Eggers, AE, 2007)
"Metabolic syndrome was more frequently associated with VPA-treated patients (41."1.34Metabolic and hormonal disturbances in women with epilepsy on antiepileptic drug monotherapy. ( Kim, JY; Lee, HW, 2007)
"Valproic acid (VPA) is an antiepileptic drug frequently used in children."1.34Severe bleeding complications during antiepileptic treatment with valproic acid in children. ( Albisetti, M; Cannizzaro, E; Schmugge, M; Wohlrab, G, 2007)
"Lamotrigine was escalated according to a target dose of 200 mg/day over 8-weeks."1.34Conversion to lamotrigine monotherapy from valproate monotherapy in older adolescent patients with epilepsy. ( Baumann, RJ; Fakhoury, TA; Hammer, AE; Kustra, RP; Messenheimer, JA; Vuong, A, 2007)
"The aim of the present study is to establish a population pharmacokinetic (PPK) model of valproate (VPA) in Chinese epileptic children to promote the reasonable use of anti-epileptic drugs."1.34Population pharmacokinetics of valproate in Chinese children with epilepsy. ( Bai, XR; Jiang, DC; Li, L; Lu, W; Wang, L; Wang, YQ, 2007)
" Both volume and absorption rate constant were fixed (14 L and 1 hr, respectively)."1.34Population pharmacokinetics of valproic acid concentrations in elderly nursing home residents. ( Ahn, JE; Birnbaum, AK; Brundage, RC; Conway, JM; Hardie, NA; Leppik, IE, 2007)
" Fluorescence polarization immunoassay (FPIA) was used to measure the serum concentration of sodium valproate and the results were standardized by dosage and body weight."1.34[Effect of UGT1A6 genetic polymorphisms on the metabolism of sodium valproate]. ( Song, JH; Sun, YP; Tan, L; Wang, Y, 2007)
"The aim of this study was to define a population pharmacokinetic model that could estimate the clearance of valproate (VPA) in a Serbian epileptic population."1.34Pharmacokinetic modeling of valproate from clinical data in Serbian epileptic patients. ( Jankovic, SM; Milovanovic, JR, 2007)
" There is an ongoing debate whether this can be attributed to chronic use of antiepileptic drugs or to the epilepsy itself."1.33Antiepileptic drugs alter reproductive endocrine hormones in men with epilepsy. ( Bjørnenak, T; Gjerstad, L; Mørkrid, L; Mørland, T; Røste, LS; Saetre, ER; Taubøll, E, 2005)
"Primary Sjogren syndrome is considered as the most frequent connective tissue disease."1.33[Sjögren's syndrome with autonomic failure and epilepsy]. ( Attout, H; Guez, S; Martre, A; Series, C, 2005)
"Valproic acid has been previously associated with hematologic toxicity, including a reversible myelodysplasia-like syndrome without chromosomal abnormalities."1.33Acute leukemia associated with valproic acid treatment: a novel mechanism for leukemogenesis? ( Bair, AK; Coyle, TE; Mehdi, S; Stein, C; Vajpayee, N; Wright, J, 2005)
"To report a pharmacokinetic interaction between valproic acid (VPA) and anticancer agents observed in an epileptic patient."1.33Pharmacokinetic interaction on valproic acid and recurrence of epileptic seizures during chemotherapy in an epileptic patient. ( Ikeda, H; Kihira, K; Murakami, T; Takano, M; Usui, T, 2005)
" VPA was not found to have any clinically significant influence on TPM pharmacokinetic and metabolic profiles."1.33A comparative study of the effect of carbamazepine and valproic acid on the pharmacokinetics and metabolic profile of topiramate at steady state in patients with epilepsy. ( Bialer, M; Britzi, M; Doose, DR; Gatti, G; La Neve, A; Levy, RH; Maryanoff, BE; Mimrod, D; Perucca, E; Soback, S; Specchio, LM; Specchio, N, 2005)
" Unlike the situation for the other drugs, the malformation rate in those exposed to valproate increased with increasing maternal drug dosage (P<0."1.33Maternal valproate dosage and foetal malformations. ( Eadie, MJ; Vajda, FJ, 2005)
" No tolerance was evident in the intravenous pentylenetetrazol test after twice-daily dosing of ABT-769 (0."1.33Preclinical profiling and safety studies of ABT-769: a compound with potential for broad-spectrum antiepileptic activity. ( Bennani, Y; Bitner, RS; Chemburkar, SR; Chen, J; Curzon, P; Dart, MJ; Decker, MW; Durmuller, N; Fox, GB; Giardina, WJ; Grayson, GK; Harris, RR; Hui, JY; Jolly, R; Komater, VA; Ku, Y; Lockwood, M; Marsh, KC; Miner, HM; Nikkel, AL; Pan, JB; Pu, YM; Radek, RJ; Roux, S; Sullivan, JP; Wang, L; Waring, JF, 2005)
" Adverse events and reasons for terminating the diet were tabulated."1.33Safety and tolerability of the ketogenic diet in pediatric epilepsy: effects of valproate combination therapy. ( Ghosh, S; Lyczkowski, DA; Pfeifer, HH; Thiele, EA, 2005)
"A 56-year-old woman with poorly controlled epilepsy, receiving valproate at subtherapeutic levels for 6 years, developed a life-threatening hyperammonemic coma following a moderate dosage increase."1.33Acute hyperammonemic coma with chronic valproic acid therapy. ( Abramson, RK; Cuturic, M, 2005)
"Lamotrigine (LTG) was prescribed in 29 patients as add-on therapy."1.33The use of lamotrigine and other antiepileptic drugs in paediatric patients at a Malaysian hospital. ( Ab Rahman, AF; Ibrahim, MI; Ismail, HI; Seng, TB, 2005)
"Oxcarbazepine is an antiepileptic drug widely used to treat partial seizures in children and adults."1.33Possible precipitation of myoclonic seizures with oxcarbazepine. ( Holmes, GL; Kaddurah, AK, 2006)
"Ten cases of reversible parkinsonism associated with VPA in 6 women and 4 men, associated with marked cognitive impairment in six cases, are described."1.33Parkinsonism and/or cognitive impairment with valproic acid therapy: a report of ten cases. ( Andréjak, M; Gras-Champel, V; Masmoudi, K; Masson, H, 2006)
"1% and never over taking dosed the antiepileptic drug 96."1.33Chrono impact versus enteric coated valproate in Thai epileptic patients. ( Arayawichanon, A; Asawavichenjinda, T; Chaisewikul, R; Kijjarak, R; Maneesuk, S; Poungvarin, N; Silpakit, O; Sirimaharaj, S; Thammasupapong, S; Tiemkao, S; Towanabut, S, 2005)
"Weight gain is a known side effect of valproate (VPA) therapy, which is associated with hyperinsulinemia and polycystic ovary-like syndrome and unfavorable lipid changes in women."1.33Insulin-related metabolic changes during treatment with valproate in patients with epilepsy. ( Isojärvi, J; Knip, M; Pakarinen, A; Pylvänen, V, 2006)
"Women with epilepsy have a higher risk of having dysmorphic child."1.33A case of fetal anticonvulsant syndrome with severe bilateral upper limb defect. ( Batukan, C; Ceylaner, G; Ceylaner, S; Guven, MA; Uzel, M, 2006)
" Conversely, for divalproex-ER dosed once-daily in the evening, for example 8 PM, a blood draw 12 to 15 hours later (ie, 8 to 11 AM) will give a plasma VPA concentration value that is 18% to 25% higher, on average, than the trough value."1.33Does it really matter when a blood sample for valproic acid concentration is taken following once-daily administration of divalproex-ER? ( Dutta, S; Reed, RC, 2006)
"Valproic acid (VPA) is an antiepileptic drug (AED) commonly used for generalized and focal epilepsies."1.33Valproate-associated coagulopathies are frequent and variable in children. ( Bell, N; Brand, J; Dempfle, CE; Gerstner, T; König, S; Longin, E; Teich, M, 2006)
"Treatment with valproic acid decreased the complaints."1.33Autonomic headache with autonomic seizures: a case report. ( Kaleagasi, H; Ozge, A; Yalçin Tasmertek, F, 2006)
" At many institutes, especially children are treated as inpatients until the desired dosage is reached."1.33Oral rapid loading of valproic acid--an alternative to the usual saturation scheme? ( Bell, N; Gerstner, T; König, SA; Longin, E, 2006)
"If lamotrigine (LTG) has to be replaced with valproate (VPA), this exchange may be complicated by adverse events that result from the complex interaction of both drugs."1.33How to replace lamotrigine with valproate. ( Steinhoff, BJ, 2006)
"Valproic acid (VPA) is an antiepileptic drug (AED) commonly used for generalized and focal epilepsies."1.33Valproic acid-induced hepatopathy: nine new fatalities in Germany from 1994 to 2003. ( Borusiak, P; Boxtermann, W; Brückner, R; Buesing, D; Degen, I; Degenhardt, V; Fitzek, S; Gerstner, T; Haensch, CA; Hanusch, R; Hartmann, M; Häussermann, P; Hoppen, T; Jungck, A; Kasper, JM; Kluger, G; Knapp, R; Koenig, SA; Korenke, GC; Kuhn, H; Lindmayer, F; Longin, E; Müller-Deile, A; Oehring, R; Richard, HH; Samii, K; Seitz, R; Specht, U; Weber, Y; Weidner, B, 2006)
"Valproic acid (VPA) has a narrow therapeutic range (50-100mg/l) and exhibits nonlinear protein binding."1.32Oral/intravenous maintenance dosing of valproate following intravenous loading: a simulation. ( Cloyd, JC; Collins, SD; Dutta, S; Granneman, GR, 2003)
"Valproic acid (VPA) is an antiepileptic drug (AED) used for generalized and absence seizures."1.32Effects of age and polytherapy, risk factors of valproic acid (VPA) hepatotoxicity, on the excretion of thiol conjugates of (E)-2,4-diene VPA in people with epilepsy taking VPA. ( Abbott, F; Farrell, K; Gopaul, S, 2003)
" We performed a cross-sectional surveillance study on pediatric patients taking valproate to evaluate the relationship between carnitine levels and demographic data including age, daily dosage of valproate, number of antiepileptic drugs, body mass index, and feeding problems."1.32Carnitine level in Chinese epileptic patients taking sodium valproate. ( Fok, TF; Fung, EL; Ho, CS; Lam, CW; Tang, NL, 2003)
"We studied 14 patients with juvenile myoclonic epilepsy (JME), 19 patients with refractory localization-related epilepsy (RLE) and 20 healthy volunteers who were matched for age and sex."1.32Uptake of GABA and activity of GABA-transaminase in platelets from epileptic patients. ( Keränen, T; Peltola, J; Rainesalo, S; Saransaari, P, 2003)
"Hyperandrogenism was not found in valproate-treated boys."1.32[Effects of valproate on sexual development]. ( Andrés Celma, M; Balaguer Martínez, JV; Castelló Pomares, ML; Contell Villagrasa, A; López García, MJ, 2003)
"Intravenous VPA loading is safe and effective for treating acute seizure emergencies in children."1.32Safety and efficacy of intravenous valproate in pediatric status epilepticus and acute repetitive seizures. ( Cunanan, C; Mills, S; Thompson, N; Yu, KT, 2003)
"Carbamazepine (CBZ) was used in seven patients at the onset of AS."1.32Absence seizures in patients with localization-related epilepsy. ( Hayakawa, F; Nakai, Y; Negoro, T; Okumura, A; Sofue, A; Toyota, N; Watanabe, K, 2003)
"Men with epilepsy are known to have reduced fertility."1.32Alterations in semen parameters in men with epilepsy treated with valproate or carbamazepine monotherapy. ( Bjørnenak, T; Gjerstad, L; Haugen, TB; Røste, LS; Saetre, ER; Taubøll, E, 2003)
"The incidence of birth defects in relation to specific AEDs was: valproate (16."1.32The Australian registry of anti-epileptic drugs in pregnancy: experience after 30 months. ( Graham, J; Hitchcock, A; Lander, C; O'Brien, TJ; Vajda, FJ, 2003)
"Pregnancy was otherwise uneventful."1.32Multiple congenital malformations including generalized hypertrichosis with gum hypertrophy in a child exposed to valproic acid in utero. ( Audeoud, F; Bernardin, A; Gaugler, C; Messer, J; Stoll, C, 2003)
"The uric acid level was significantly decreased in group A compared with group B (p < 0."1.32Hypouricemia in severely disabled children II: influence of elemental enteral nutrition on the serum uric acid levels. ( Abe, T; Yamazaki, S; Yoshikawa, H, 2004)
"One hundred seventy-eight men had focal epilepsy (117 of these had temporal lobe epilepsy [TLE]) and 22 idiopathic generalized epilepsy (IGE)."1.32Epilepsy syndrome, focus location, and treatment choice affect testicular function in men with epilepsy. ( Bauer, J; Blumenthal, S; Reuber, M; Stoffel-Wagner, B, 2004)
"Men with epilepsy have reduced fertility, and antiepileptic drugs may affect semen quality."1.32Effect of epilepsy and antiepileptic drugs on male reproductive health. ( Isojärvi, JI; Juntunen, KS; Löfgren, E; Päivänsalo, M; Pakarinen, AJ; Rautakorpi, I; Tuomivaara, L, 2004)
"Polycystic ovary syndrome was more common in patients on medication (38%; in 63% on VPA, in 25% on other medication) than in patients off medication (6%) or in controls (11%) (p = 0."1.32Long-term reproductive endocrine health in young women with epilepsy during puberty. ( Isojärvi, JI; Järvelä, IY; Knip, M; Mikkonen, K; Pakarinen, AJ; Tapanainen, JS; Vainionpää, LK, 2004)
"The average annual cost of outpatient treatment of epilepsy was found to be 47 US dollars per patient."1.32Cost of epilepsy in patients attending a secondary-level hospital in India. ( Kapoor, SK; Krishnan, A; Sahariah, SU, 2004)
" However, there is no information available on the number of therapeutic abortions, or the different types of epilepsy or drug dosage in the two treatment groups."1.32Major malformations in infants exposed to antiepileptic drugs in utero, with emphasis on carbamazepine and valproic acid: a nation-wide, population-based register study. ( Källén, B; Wide, K; Winbladh, B, 2004)
"001) difference in median values of the absorption rate constant was found between enteric-coated and sustained-release VAL formulations."1.32Nonparametric population modeling of valproate pharmacokinetics in epileptic patients using routine serum monitoring data: implications for dosage. ( Bondareva, IB; Jelliffe, RW; Sokolov, AV; Tischenkova, IF, 2004)
"Valproic acid pharmacokinetic profile and tolerability after administration of divalproex sodium extended-release tablets was characterized in older children and adolescents."1.32Divalproex-ER pharmacokinetics in older children and adolescents. ( Biton, V; Conway, JM; Dutta, S; Kearns, GL; Reed, MD; Sallee, FR; Zhang, Y, 2004)
"The aims of our study were to evaluate whether deficits in color vision exist in epileptic adolescents, to study if monotherapy with valproic acid (VPA) and carbamazepine (CBZ) can affect color vision, and to determine the possible relationship between abnormal color vision tests and AEDs dosage and their serum concentrations."1.32Color vision in epileptic adolescents treated with valproate and carbamazepine. ( Chiarelli, F; Gallenga, PE; Lobefalo, L; Morgese, G; Priolo, T; Rapinese, M; Trotta, D; Verrotti, A, 2004)
" The severity of the cognitive side effects of TPM may be related to dosing to a certain extent, but this relationship may be disclosed only with larger sample sizes."1.32Cognitive profile of topiramate as compared with lamotrigine in epilepsy patients on antiepileptic drug polytherapy: relationships to blood serum levels and comedication. ( Elger, CE; Helmstaedter, C; Kockelmann, E, 2004)
" Recently, a new extended-release (ER) formulation of divalproex sodium has become available, which allows for once-daily dosing and provides prolonged therapeutic serum levels."1.32Clinical comparison of extended-release divalproex versus delayed-release divalproex: pooled data analyses from nine trials. ( Centorrino, F; Collins, MA; Smith, MC; Welge, JA, 2004)
"We describe the incidence of newly treated epilepsy in primary care and patterns of antiepileptic drug prescription, numbers of patients who remain on initial therapy and health service utilisation."1.32The outcome of initiation of antiepileptic drug monotherapy in primary care: a UK database survey. ( Buchan, S; Kerr, MP; Morgan, CL, 2004)
"Using sparse data of valproate (VPA) serum concentrations to build a population pharmacokinetic (PPK) model of VPA in Chinese children with epilepsy and to predict serum concentrations for new patients using a Bayesian approach."1.32Population pharmacokinetic model of valproate and prediction of valproate serum concentrations in children with epilepsy. ( Jiang, DC; Wang, L, 2004)
"Since Fanconi syndrome was considered to be caused by sodium valproate, it was stopped."1.31Fanconi syndrome caused by sodium valproate: report of three severely disabled children. ( Abe, T; Watanabe, T; Yoshikawa, H, 2002)
"Despite the frequency of seizure disorders in the human population, the genetic basis for these defects remains largely unclear."1.31Anticonvulsant valproate reduces seizure-susceptibility in mutant Drosophila. ( Kuebler, D; Tanouye, M, 2002)
"To determine population-based pharmacokinetic parameters for intravenous valproic acid, and the factors influencing these parameters, in Korean adults."1.31Population pharmacokinetics of intravenous valproic acid in Korean patients. ( Kang, SS; Kim, ON; Lee, SB; Lee, YB; Park, HM; Shin, DJ; Yim, DS, 2002)
"Landau-Kleffner syndrome is marked by an acquired aphasia in children who have had normal language and motor development."1.31Landau-Kleffner syndrome beginning with stuttering: case report. ( Kadioğlu, B; Serdaroğlu, G; Tütüncüoğlu, S, 2002)
"Determining antiepileptic drug (AED) concentration in biological fluids and calculating its dosage on this basis is a long-term method in the treatment of epilepsy."1.31[Therapeutic antiepileptic drug monitoring: thirteen years of experience in the Laboratory of Clinical Neuropharmacology in the Chair and Department of Developmental neurology]. ( Galas-Zgorzalewicz, B; Steinborn, B, 2000)
" Everyone received a drug dosage which gave an adequate therapeutic plasma concentration and satisfactory seizure control."1.31[Bimodal evoked potentials during long-term therapy with conventional or slow release preparations of carbamazepine and valproic acid in children and adolescents with epilepsy]. ( Zgorzalewicz, M, 2000)
" In this study, we examined the anticonvulsant and adverse effects of the three clinically established AEDs carbamazepine (CBZ), phenobarbital (PB), and valproate (VPA) once per month in the same two groups of amygdala-kindled rats over a period of 9 (group 1) or 6 (group 2) consecutive months."1.31Repeated acute testing of anticonvulsant drugs in amygdala kindled rats: increase in anticonvulsant but decrease in adverse effect potential. ( Fiedler, M; Löscher, W, 2000)
"Carnitine is an nonproteic nitrogenated compound acid present in all mammalian tissue and its principal activity is the long-chain fatty acid transport across the mitochondrial membrane for beta-oxidation."1.31[Antiepileptic drugs and carnitine]. ( Artuch, R; Campistol, J; Chávez, B; Vilaseca, MA, 2000)
"The course of epilepsy is more difficult to predict, but failure to respond to the first AED is worrisome."1.31Prognosis of seizures occurring in the first year. ( Datta, AN; Wirrell, EC, 2000)
"Carbamazepine treatment alters the serum lipid profile of the children in such a way that it facilitates the development of atherosclerosis."1.31Carbamazepine and valproic acid: effects on the serum lipids and liver functions in children. ( Demircioğlu, S; Dirik, E; Soylu, A, 2000)
"Valproic acid was converted directly into its pentafluorobenzyl ester derivative without the need to perform any extraction from the biologic fluid."1.31Assessment of drug concentrations in tears in therapeutic drug monitoring: I. Determination of valproic acid in tears by gas chromatography/mass spectrometry with EC/NCI mode. ( Honda, A; Kitagawa, S; Miyamoto, J; Miyazaki, H; Nakajima, M; Ohya, M; Sato, S; Shimada, K; Shoda, J; Yamato, S, 2000)
" As increasing numbers of bipolar patients are in long-term treatment with valproate, there is an important need for further research that clarifies the relationship between long-term administration of valproate and other mood stabilizers and the potential development of reproductive endocrinologic abnormalities, and for increased awareness among clinicians and patients of the unknown potential for these worrisome side-effects."1.31Valproate treatment and the risk of hyperandrogenism and polycystic ovaries. ( Soares, JC, 2000)
"Autism has been described in association with a variety of medical and genetic conditions."1.31Fetal valproate syndrome and autism: additional evidence of an association. ( Cunningham, M; Hersh, JH; Kerr, B; King, J; Stephan, M; Williams, G, 2001)
" To avoid complex pharmacokinetic interactions among multiple antiepileptic drugs, the data on serum concentrations in the current study were collected from patients who were co-administered only one additional antiepileptic drug (phenobarbital-carbamazepine, phenobarbital-valproic acid, or carbamazepine-valproic acid) or who received monotherapy."1.31Pharmacokinetic interactions among phenobarbital, carbamazepine, and valproic acid in pediatric Japanese patients: clinical considerations on steady-state serum concentration-dose ratios. ( Aoyama, T; Higuchi, S; Hokazono, T; Ohdo, S; Satou, M; Yukawa, E, 2000)
"A possible role of the seizure disorder or, alternatively, of the use of antiepileptic drugs (AEDs) has been suggested as the pathogenic mechanism."1.31Characterization of reproductive endocrine disorders in women with epilepsy. ( Bilo, L; Di Carlo, C; Meo, R; Nappi, C; Striano, S; Valentino, R, 2001)
"Ideally any pregnancy in a woman being treated for epilepsy should be planned, and both an obstetrician and a neurologist should be consulted."1.31Craniosynostosis and fetal exposure to sodium valproate. ( Barcik, U; Bourgeois, M; El Ghouzzi, V; Lajeunie, E; Renier, D; Thorne, JA, 2001)
"Carbamazepine and depakine treatment during at least 6 months does not predispose to ovary polycystosis syndrome."1.31[The pharmacological and hormonal effects of carbamazepine and valproic acid in the treatment of reproductive age women with epilepsy]. ( Karlov, VA; Kushlinskiĭ, NE; Vlasov, PN, 2001)
"In our study, we report a patient having head trauma history with partial and secondary generalized seizures taking 1500 mg/day valproate."1.31Reversible valproate-induced choreiform movements. ( Bingol, CA; Guleryuz, M; Gunal, DI, 2002)
"Clobazam is a 1,5-benzodiazepine effective in antiepileptic therapy of children and adults."1.30Interactions of clobazam with conventional antiepileptics in children. ( Cortez, M; Daneman, R; Hwang, P; Koren, G; Menzano, E; Sherwin, AL; Theis, JG, 1997)
"Treatment with carbamazepine decreased plasma OE1S levels from a mean value of 810."1.30Differential effect of carbamazepine and valproate monotherapy on plasma levels of oestrone sulphate and dehydroepiandrosterone sulphate in male epileptic patients. ( Berntsen, H; Engelsen, BA; Geisler, J; Geisler, S; Lønning, PE, 1997)
" The purpose of our study was to evaluate the effects of chronic administration of valproate (VPA), phenytoin (PHT), and MK-801 on the change in seizure phenotype observed in our model system."1.30Effects of valproate, phenytoin, and MK-801 in a novel model of epileptogenesis. ( Applegate, CD; Ozduman, K; Samoriski, GM, 1997)
"Valproic acid is an antiepileptic drug in widespread use."1.30Thrombocytopenic purpura and anemia in a breast-fed infant whose mother was treated with valproic acid. ( Neiderud, J; Stahl, MM; Vinge, E, 1997)
" AWD 140-190 thus presents an orally active and safe anticonvulsant agent, which is structurally unrelated to anticonvulsants currently used."1.30AWD 140-190: a new anticonvulsant with a very good margin of safety. ( Bartsch, R; Engel, J; Rostock, A; Rundfeldt, C; Tober, C; Unverferth, K; White, HS; Wolf, HH, 1997)
"Valproic acid (VPA) is an antiepileptic drug widely used in paediatrics."1.30[Evaluation of the effect of long term valproic acid treatment on plasma levels of carnitine, ammonia and amino acids related to the urea cycle in pediatric epileptic patients]. ( Jiménez, C; Lluch-Fernández, MD; Marchante-Serrano, C; Navarro-Quesada, FJ; Vaquero-Abellán, M, 1997)
"Oligomenorrhea occurred in 16 patients, polymenorrhea in 2."1.30Menstrual cycle and ovary alterations in women with epilepsy on antiepileptic therapy. ( Copello, F; Deagatone, C; Ferrari, E; Galimberti, CA; Gazzerro, E; Gianelli, MV; Magri, F; Manni, R; Murialdo, G; Polleri, A; Rollero, A; Sampaolo, P; Tartara, A, 1997)
"Epilepsy is a relatively common problem in children, adults and the elderly."1.30Treatment of the epileptic patient in the dental office. ( Haller, JS; Kennedy, BT, 1998)
" Reduction of VPA dosage and subsequent discontinuation 4 months later resulted in disappearance of clinical symptoms with a 20-point improvement at IQ testing and recovery of previous PM score."1.30Reversible pseudoatrophy of the brain and mental deterioration associated with valproate treatment. ( Belmonte, A; Canapicchi, R; Casalini, C; Guerrini, R; Perucca, E, 1998)
"A relationship between epilepsy and migraine has long been postulated, but the nature of this interaction is still debated."1.30Migraine with visual aura and photosensitive epileptic seizures. ( Bartolomei, F; Donnet, A, 1997)
" Patients received phenobarbitone as monotherapy or in combination with either of the antiepileptic drugs carbamazepine or valproic acid."1.30Detection of a drug-drug interaction on population-based phenobarbitone clearance using nonlinear mixed-effects modeling. ( Aoyama, T; Higuchi, S; Ohdo, S; To, H; Yukawa, E, 1998)
"The visual aura experiences reported in vague terms by some patients with RE may represent ictal dyslexia."1.30Reading epilepsy: report of five new cases and further considerations on the pathophysiology. ( Mayer, T; Reker, M; Wolf, P, 1998)
" We propose that individual dosage adjustment in VPA + CBZ polytherapy should be combined with monitoring of relevant enzyme activities in serum."1.30Valproate and carbamazepine comedication changes hepatic enzyme activities in sera of epileptic children. ( Cepelak, I; Lenicek, J; Mandusić, A; Rekić, B; Zanić Grubisić, T, 1998)
" In those patients who use these drugs at increased dosage levels or for long periods, the possibility of tubular dysfunction may be increased, and these dysfunctions may manifest in clinical symptoms."1.30N-acetyl-beta-glucosaminidase and beta-galactosidase activity in children receiving antiepileptic drugs. ( Cenani, A; Cengiz, M; Cengiz, S; Seven, M; Yüksel, A, 1999)
"Valproic acid (VPA)-induced encephalopathy is a rarely considered side effect, with somnolence, reduced motor activity and severe deterioration of cognitive and behavioural abilities."1.30[Encephalopathies caused by valproate]. ( Bräunig, P; Göbel, R; Görtzen, A, 1999)
"This report characterizes seizures in a novel genetic model of developmental epilepsy, the Flathead (FH) rat."1.30Characterization of seizures in the flathead rat: a new genetic model of epilepsy in early postnatal development. ( D'Mello, SR; LoTurco, JJ; Rattan, S; Sarkisian, MR, 1999)
"Felbamate (FBM) was initiated and VPA discontinued for improved seizure control."1.30Male infertility: possible association with valproate exposure. ( McCoy, GB; Yerby, MS, 1999)
" In both group A and group B patients, plasma ammonia levels were correlated with the valproic acid dosage (r = 0."1.30Carnitine deficiency and hyperammonemia in children receiving valproic acid with and without other anticonvulsant drugs. ( Chiarelli, F; Greco, R; Morgese, G; Verrotti, A, 1999)
"A 29-year-old female patient with Friedreich's ataxia and partial seizures with acute liver failure during VPA treatment is reported."1.30Fatal liver failure associated with valproate therapy in a patient with Friedreich's disease: review of valproate hepatotoxicity in adults. ( Hehlmann, R; Heubner, C; Holm, E; König, I; König, SA; Schenk, M; Sick, C; Weiss, A, 1999)
" Valproate, when the proper therapeutic dosage was belatedly realized, was seen as a superior treatment for generalized and partial epilepsies."1.30Clinical experience with new antiepileptic drugs: antiepileptic drugs in Europe. ( Loiseau, PJ, 1999)
"Rett's syndrome is a neurodevelopmental disorder which is caused by a mutation on the x-chromosome; thus, it only affects the female sex."1.30[Rett's syndrome: pathophysiology and anesthesiological implications]. ( Häuser, FM; Lennartz, H; Lukasewitz, P; Wichert, A, 1999)
"The medication regimens used to treat epilepsy are further complicated by the fact that most seizure medications are metabolized in the liver and have the potential for serious pharmacokinetic drug-drug interactions with many other medications."1.29Practical considerations in anticonvulsant therapy--Part 2. ( Cloyd, J; Garnett, WR; Holmes, GL; Meyer, MC; Schiffer, JR, 1995)
"One also had features of infantile autism."1.29Fetal valproate syndrome: clinical and neuro-developmental features in two sibling pairs. ( Chesler, N; Christianson, AL; Kromberg, JG, 1994)
"In this model, the threshold for seizures in rats is determined at short time intervals by applying ramp-shaped electrical pulse-trains directly to the cerebral cortex, allowing one to determine the time course of anti- or proconvulsant drug effects in individual rats."1.29Dose-dependent anticonvulsant and proconvulsant effects of nitric oxide synthase inhibitors on seizure threshold in a cortical stimulation model in rats. ( Gerecke, U; Koch, R; Löscher, W; Mevissen, M; Richter, A; Rundfeldt, C, 1995)
"Carbamazepine treatment resulted in prolongation of peak latencies of waves I-III-V and interpeak intervals I-III and I-V."1.29Effects of carbamazepine and valproate on brainstem auditory evoked potentials in epileptic children. ( Cenani, A; Dirican, A; Keskin, G; Senocak, D; Sozuer, D; Yalcin, E; Yuksel, A, 1995)
"Pancreatitis is usually considered a rare side effect of valproate."1.29Valproate-associated pancreatitis and cholecystitis in six mentally retarded adults. ( Buzan, RD; Dubovsky, SL; Firestone, D; Thomas, M, 1995)
"Trends in treatment of epilepsy in an institution for handicapped patients with epilepsy were investigated in a retrospective longitudinal study."1.29[Changes in drug therapy and in seizure frequency in an institution for epilepsy patients between 1971 and 1986]. ( May, T; Wohlhüter, M; Wolf, P, 1994)
" A review of published studies involving small numbers of elderly subjects or patients given phenytoin sodium, valproic acid, or carbamazepine demonstrates decreased protein binding and intrinsic clearance and increased half-life with advancing age."1.29Antiepileptics in the elderly. Pharmacoepidemiology and pharmacokinetics. ( Cloyd, JC; Lackner, TE; Leppik, IE, 1994)
" All these patients were receiving the usual dosage (1000 to 1500 mg per day) of Valproic acid (VPA)."1.29Impairment of consciousness induced by valproate treatment following neurosurgical operation. ( Baulac, M; de Billy, A; Durand, G; Landau, J; Philippon, J, 1993)
"A retrospective study of 113 patients treated with a sustained-release form of valproate (SRF-VPA), known as the "chrono" formulation in most European countries, led to the following conclusions: Patients treated with the old VPA formulation could immediately receive the same daily dosage of SRF-VPA without loss of seizure control when administered as a single evening dose."1.29A retrospective study of 113 epileptic patients treated with sustained-release valproate. ( Despland, PA, 1994)
"Valproic acid (VPA) may cause impaired platelet function, thrombocytopenia and, occasionally, severe bleeding."1.29Valproate-mediated disturbances of hemostasis: relationship to dose and plasma concentration. ( Collins, M; Gidal, B; Jones, J; Maly, M; Pitterle, M; Spencer, N; Williams, E, 1994)
"Valproic acid is a useful antiepileptic drug, with occasional gastrointestinal side effects."1.29[Hepatotoxicity induced by valproic acid in adults. Report of 3 cases]. ( Aguilera, L; Chesta, J; Galdames, D; Silva, C, 1993)
" In this context, anticonvulsant and neurotoxic pharmacodynamic interactions between phenytoin (PHT) and valproate (VPA) were assessed in an experimental model in mice."1.29Pharmacodynamic interactions between phenytoin and valproate: individual and combined antiepileptic and neurotoxic actions in mice. ( Bourgeois, BF; Chez, MG; Knowles, WD; Pippenger, CE, 1994)
" The frequency of withdrawal symptoms was significantly related to the dose of valproate given to the mothers in the third trimester, and there was a tendency for both the frequency of the minor abnormalities and the major malformations to be related to the valproate dosage in the first trimester."1.29Malformations, withdrawal manifestations, and hypoglycaemia after exposure to valproate in utero. ( Ebbesen, F; Thisted, E, 1993)
" VPA dosage was tapered and discontinued, with accompanying resolution of clinical, immunological and hematological signs of SLE 6 weeks after VPA discontinuation."1.29Valproate-induced systemic lupus erythematosus in a patient with partial trisomy of chromosome 9 and epilepsy. ( Diomedi, M; Gigli, GL; Grazia Pomponi, M; Masala, C; Pauri, F; Placidi, F; Scalise, A; Silvestri, G, 1996)
"Felbamate is a new antiepileptic drug (AED) with a good safety profile."1.29Weight loss in patients taking felbamate. ( Bergen, DC; Hoeppner, TJ; Kanner, A; Ristanovic, RK; Waicosky, K, 1995)
"Treatment with carbamazepine raised serum total cholesterol levels, C-HDL, phospholipid and A-I apoprotein in all groups, low density lipoproteins in females and B apoprotein males."1.29[The effects of phenobarbital, valproic acid and carbamazepine on the serum lipids and lipoproteins in a pediatric population]. ( Braga Hernández, S; Crespo Hernández, M; de Juan Frigola, J, 1996)
" A patient was only considered twice if his comedication or OCBZ dosage had been changed."1.29Fluctuations of 10-hydroxy-carbazepine during the day in epileptic patients. ( May, TW; Rambeck, B; Sälke-Kellermann, A, 1996)
" Routine clinical pharmacokinetic data (N = 1,010) collected from 466 patients receiving carbamazepine were analyzed according to a simple steady-state pharmacokinetic model with the use of NONMEM, a computer program designed for population pharmacokinetic analysis that allows pooling of data."1.29Detection of carbamazepine drug interaction by multiple peak approach screening using routine clinical pharmacokinetic data. ( Aoyama, T; Yukawa, E, 1996)
"6%) and without significant dose dependency, suggesting that this parameter may be useful for guiding VPA dosage adjustment and monitoring patient compliance."1.28Relationship between serum concentration and dose of valproic acid during monotherapy in adult outpatients. ( Oles, KS; Penry, JK; Tisdale, JE; Tsuyuki, RT, 1992)
"Chromosome fragility was sought in a well-defined cohort of patients with Lennox-Gastaut epilepsy syndrome."1.28Chromosome fragility in the Lennox-Gastaut epilepsy syndrome. ( Beran, RG; Smith, A, 1992)
"Cerebral cavernous angioma (cavernoma) has previously been treated by resection for all presentations when surgically resectable."1.28Cerebral cavernous angioma: a potentially benign condition? Successful treatment in 16 cases. ( Churchyard, A; Grainger, K; Khangure, M, 1992)
" Pharmacokinetic experiments with trans-2-en-VPA indicated non-linear kinetics with dose-dependent elimination rate and enterohepatic recirculation."1.28Pharmacokinetics, anticonvulsant efficacy, and adverse effects of trans-2-en-valproate after acute and chronic administration in amygdala-kindled rats. ( Hönack, D; Löscher, W; Rundfeldt, C, 1992)
" The pharmacokinetic parameters, necessary to define the pharmacokinetics of valproic acid, were calculated both after single dose: Cmax, tmax, kel, t1/2, Vd, AUC and Cl, and at steady state: Cminss Cmaxss and Fl%."1.28Single dose and steady state pharmacokinetics of valproic acid in adult epileptic patients. ( Lević, Z; Miljković, B; Pokrajac, M; Varagić, V, 1991)
"Free carnitine was low in tube-fed patients, as compared with that in oral-fed patients."1.28[The problems of valproate therapy in severely handicapped children--valproate induced hyperammonemia and hypocarnitinemia]. ( Iwamoto, H; Kobayashi, T; Matsui, K; Miyake, S; Ohtsuki, N; Yamada, M, 1991)
" They were divided into 3 groups treated with Mg-VPA in dosage of 800 mg, 600 mg and 400mg respectively at 7 pm in an attempt to find out an appropriate dosage with which the effective serum level could be maintained in the night time for those patients with only nocturnal seizures."1.28[Appropriate dosage for maintaining effective serum level at night after taking one dose of magnesium valproate with separate measurements of serum Mg++ concentration]. ( Yan, CS, 1991)
"Free plasma level/dose ratio of valproic acid (L/D-F) can be more effective than total plasma level/dose ratio (L/D-T) in adjusting dosage regimens."1.28Total and free valproic acid: plasma level/dose ratio in monotherapy. ( Abadín, JA; Durán, JA; Sánchez, A; Serrano, JS, 1991)
"Sister-chromatid exchange (SCE) and chromosome aberrations have been studied in peripheral lymphocytes of 20 epileptic children treated in monotherapy with valproic acid (VPA) for 6-52 months and in 2 matched control groups."1.28The effect of valproic acid on SCE and chromosome aberrations in epileptic children. ( Hu, LJ; Huang, YQ; Lu, BQ; Lu, XF, 1990)
" In order to define the minimal dosage of fentanyl required, the MD was titrated according to increases or decreases in the heart rate and/or mean arterial pressure exceeding 15 per cent of baseline ward values."1.28Anticonvulsant therapy increases fentanyl requirements during anaesthesia for craniotomy. ( Modica, PA; Spitznagel, EL; Tempelhoff, R, 1990)
" Eighty-four patients had been established on treatment with a single anticonvulsant drug (35 carbamazepine (CBZ), 30 sodium valproate (VPA), 19 phenytoin (PHT)) at unaltered dosage for the previous 3 months."1.28Cognitive function in adult epileptic patients established on anticonvulsant monotherapy. ( Brodie, MJ; Butler, E; Gillham, RA; Larkin, JG; Wiedmann, KD; Williams, N, 1990)
"Carbamazepine (CBMZP) has been implicated as an inhibitor of the activities of 5-aminolaevulinic acid dehydratase (ALA-D) and uroporphyrinogen I synthetase (URO-S)."1.28Protoporphyrinaemia and decreased activities of 5-aminolevulinic acid dehydrase and uroporphyrinogen I synthetase in erythrocytes of a Vitamin B6-deficient epileptic boy given valproic acid and carbamazepine. ( Carson, R; Haust, HL; Peter, F; Poon, HC; VanDeWetering, C, 1989)
"Phenytoin treatment may impair the validity of the caffeine liver function test."1.28Effect of phenytoin, carbamazepine, and valproic acid on caffeine metabolism. ( Büchsel, R; Kohl, D; Kreiten, K; Matern, S; Wietholtz, H; Zysset, T, 1989)
"There was a greater risk of recurrence among girls."1.28[Factors influencing the effectiveness of preventive treatment of febrile convulsions]. ( Armijo Simón, JA; Arteaga Manjón-Cabeza, R; Herranz Fernández, JL, 1989)
" Pharmacokinetic interactions between antiepileptic drugs may lead to considerable fluctuation in plasma drug concentration, and monotherapy is often preferable."1.27Pharmacokinetics of antiepileptic drugs. ( Neuvonen, PJ; Tokola, RA, 1983)
"From the analysis of 115 cases of primary generalized epilepsies treated for a mean duration of 43 months with sodium valproate as sole therapy, it appears that: the mean effective daily dosage is 21 mg/kg; the efficacy of valproate proved excellent in 82."1.27[Monotherapy with sodium valproate in generalized primary epilepsy. 2d phase: Study of long-term efficacy and tolerance]. ( Feuerstein, J; Revol, M; Roger, J; Sallou, C; Truelle, JL; Vercelletto, P; Weber, M, 1983)
" Serum level decline was biphasic in both instances with a terminal half-life of 27."1.27The effects of peritoneal dialysis on the single dose and steady state pharmacokinetics of valproic acid in a uremic epileptic child. ( Abbott, FS; Farrell, K; Ferguson, S; Godolphin, WJ; Orr, JM, 1983)
"We previously found that chronic administration of sodium valproate to suckling infant mice reduced plasma beta-hydroxybutyrate levels but had no effect on plasma free fatty acid or glycerol concentrations."1.27Chronic valproate administration reduces fasting ketonemia in children. ( Carroll, JE; Dodson, WE; Hauhart, RE; Tasch, V; Thurston, JH, 1983)
"Equivalent doses of enteric-coated divalproex were substituted for valproic acid in 15 epileptic patients who were on a three- or four-times-a-day dosing schedule."1.27Twice-daily dosing of valproate with divalproex. ( Hammond, EJ; Karas, BJ; Perchalski, RJ; Wilder, BJ, 1983)
"Phenytoin continues to be a very popular drug for most types of seizures, but carbamazepine, used adjunctively until recently, is effective as monotherapy for the control of partial seizures, particularly those of the complex partial variety."1.27Treatment of the nonconvulsive epilepsies. ( Dreifuss, FE, 1983)
"Only when the epilepsy is uncontrolled despite high plasma concentrations which cannot be raised because of side effects, a second drug should be given."1.27[Pharmacotherapy of epilepsy--current problems and controversies]. ( Schmidt, D, 1983)
"5 of these patients developed toxic encephalopathy with hyperammonemia induced by VPA."1.27Treatment of epileptic patients with valproic acid does not modify plasma and urine short-chain-fatty acids. ( Arnetoli, G; Boncinelli, L; Campostrini, R; Paganini, M; Zaccara, G; Zappoli, R, 1983)
" Pharmacokinetic parameters were equivalent for both preparations except for an absorption lag with the enteric-coated form."1.27Pharmacokinetics of enteric-coated valproic acid. ( Albright, PS; Bruni, J; Suria, D, 1984)
"Side effects of carbamazepine (CBZ), valproate (VPA) and clonazepam (CZP) are rare during long-term use but rather common and usually transient during the early phases of treatment."1.27Side effects of carbamazepine, valproate and clonazepam during long-term treatment of epilepsy. ( Keränen, T; Sivenius, J, 1983)
" However, whereas toxic reactions following phenytoin and carbamazepine are characterised by a rather short duration of exposure before symptoms occur with accompanying clinical features of hypersensitivity, valproate-induced hepatic toxicity exhibits no signs of hypersensitivity and often occurs following prolonged exposure, speaking in favor of a metabolic aberration as the underlying cause."1.27Hepatic toxicity of antiepileptic drugs: a review. ( Bentsen, KD; Gram, L, 1983)
" In 8 of them, a therapeutic dosage of VPA caused modifications of the state of consciousness ranging from coma to drowsiness and stupor."1.27Hyperammonemia and valproate-induced alterations of the state of consciousness. A report of 8 cases. ( Arnetoli, G; Campostrini, R; Moroni, F; Paganini, M; Zaccara, G; Zappoli, R, 1984)
" There were no significant differences between weight gainers and weight-stable patients with regard to age, sex, pretreatment overweight, duration of treatment, dosage or serum levels of valproate."1.27Weight gain during treatment with valproate. ( Andersen, T; Dam, M; Dinesen, H; Gram, L, 1984)
" Significant positive correlations were found between the dosage of CBZ, DPH, PMD and PB and both indices of enzyme induction."1.27A comparative study of the relative enzyme inducing properties of anticonvulsant drugs in epileptic patients. ( Hedges, A; Makki, KA; Perucca, E; Richens, A; Ruprah, M; Wilson, JF, 1984)
"Valproic acid (VPA) was given to 24 epileptic patients who were already being treated with other antiepileptic drugs."1.27Acute changes of blood ammonia may predict short-term adverse effects of valproic acid. ( Arnetoli, G; Baruzzi, A; Campostrini, R; Moroni, F; Paganini, M; Targioni, G; Valenza, T; Zaccara, G; Zappoli, R, 1984)
"Most electrically induced seizures involve forebrain structures, such as the amygdala or frontal cortex, but the following studies characterized a specific anatomic site in the inferior colliculus which generated seizure-like behavior after a single, low current electrical stimulation."1.27Electrically elicited seizures from the inferior colliculus: a potential site for the genesis of epilepsy? ( Breese, GR; Frye, GD; Greenwood, RS; McCown, TJ, 1984)
" Mean elimination half-life was 8."1.27Steady-state valproate pharmacokinetics during long term therapy. ( Eadie, MJ; Heazlewood, V; McKauge, L; Tyrer, JH, 1983)
"Free and total valproic acid (VPA) pharmacokinetic evaluation was carried out at steady state in six young epileptics who were also receiving other anticonvulsants."1.27Free valproic acid: steady-state pharmacokinetics in patients with intractable epilepsy. ( Budnik, D; Hall, K; Irvine-Meek, J; Leroux, M; Otten, N; Seshia, S, 1984)
"Carbamazepine was the most effective to block SEA at concentrations of 1-15 microM."1.27Effects of anticonvulsants on spontaneous epileptiform activity which develops in the absence of chemical synaptic transmission in hippocampal slices. ( Franceschetti, S; Hamon, B; Heinemann, U; Konnerth, A; Yaari, Y, 1985)
" They also indicate that chronic administration of sodium valproate, hence activation of central gamma-aminobutyric acid system, results in a blunting of the stimulated GH and ACTH secretion."1.27Neuroendocrine effects of chronic administration of sodium valproate in epileptic patients. ( Cavagnini, F; Danesi, L; Dubini, A; Invitti, C, 1988)
"The purpose of this study was to assess the effects of chronic administration of gradually increasing doses of the anti-petit mal agents, ethosuximide (15-60 mg/kg/day) and valproic acid (7."1.27Behavioral toxicity of chronic ethosuximide and sodium valproate treatment in the epileptic baboon, Papio papio. ( Killam, EK; Paule, MG, 1986)
" Twenty-three patients complained of various long-term adverse effects, while the other 17 remained symptom-free."1.27Long-term treatment with sodium valproate: monitoring of venous ammonia concentrations and adverse effects. ( Arnetoli, G; Campostrini, R; Messori, A; Paganini, M; Valenza, T; Zaccara, G; Zappoli, R, 1987)
"Carbamazepine, in contrast, has rather a stimulatory action."1.27[Modification of psychophysical performance of the human by anticonvulsants]. ( Meyer, FP; Walther, H, 1987)
" These results show that barbiturates should not be first-choice drugs in patients who have a chronic disease such as epilepsy, and indicate a schedule for barbiturate withdrawal which is safe and independent of hospitalization or monitoring of antiepileptic drug serum concentrations."1.27Barbiturate-refractory epilepsy: safe schedule for therapeutic substitution. ( Bittencourt, PR; Gorz, AM; Silvado, CE, 1986)
" Although rectal administration of sodium valproate (NaVPA) has been shown to be a possible alternative route, little is known about the bioavailability and local effects during repeated administration of NaVPA suppositories."1.27Bioavailability of sodium valproate suppositories during repeated administration at steady state in epileptic children. ( Bourgeois, BF; Issakainen, J, 1987)
"In particular, memory deficits, attentional problems, psychomotor slowing and reading and writing difficulties are highlighted, and the impact of the seizures, brain damage, and anticonvulsant drugs on cognitive function noted."1.27[Cognitive effects of antiepileptic drugs]. ( Trimble, R, 1987)
"Phenytoin levels were reduced to 37% of the original values, although the drug was given intravenously."1.27An interaction between cytostatic and anticonvulsant drugs. ( de Voogd-van der Straaten, I; Neef, C, 1988)
" The terminal half-life of free VPA (6."1.27Pharmacokinetics of free and total sodium valproate in adolescents and young adults during maintenance therapy. ( Herngren, L; Nergårdh, A, 1988)
" Children can begin to receive valproate treatment in a dosage of 20 to 30 mg/kg per day in two or three divided doses."1.27Valproate monotherapy in children. ( Murphy, JV, 1988)
" In each patient, the average unbound fraction for a dosing interval increased with increase in sodium valproate dose."1.27Changes in clearance of sodium valproate with changes in dose. ( Bury, RW; Fullinfaw, RO; Kilpatrick, CJ; Moulds, RF, 1987)
"01), and shorter half-life (9."1.27Comparison of steady-state pharmacokinetics of valproic acid in children between monotherapy and multiple antiepileptic drug treatment. ( Chiba, K; Hori, M; Iriki, T; Ishizaki, T; Naitoh, H; Shirai, Y; Suganuma, T, 1985)
" The mechanisms responsible for these effects have not been elucidated and possibly include decreased bioavailability or compliance, increased metabolic clearance, or decreased plasma protein binding."1.27Effects of pregnancy on antiepileptic drug utilization. ( Levy, RH; Yerby, MS, 1985)
"According to our convulsion intensity scoring system, these animals have an audiogenic response score (ARS) of 3 and the colony is designated the GEPR-3 colony."1.27Anticonvulsant drugs and the genetically epilepsy-prone rat. ( Dailey, JW; Jobe, PC, 1985)
"The % of gingival hyperplasia was significantly higher (P less than 0."1.27The effects of phenytoin and sodium valproate on the periodontal health of adult epileptic patients. ( Seymour, RA; Smith, DG; Turnbull, DN, 1985)
" Valproic acid elimination half-life increased from 7."1.27Valproic acid pharmacokinetics in children. II. Discontinuation of concomitant antiepileptic drug therapy. ( Cloyd, JC; Fischer, JH; Kriel, RL, 1985)
"Spina Bifida, Congenital Heart Defects, Clefts, Diaphragmatic Hernia and Trisomy 18 were more frequent than expected among babies with maternal epilepsy."1.27Maternal epilepsy and birth defects: a case-control study in the Italian Multicentric Registry of Birth Defects (IPIMC). ( Bertollini, R; Mastroiacovo, P; Segni, G, 1985)
" However, no adjustment of phenytoin dosage is warranted, unless clinically indicated, since the free phenytoin levels remain unchanged."1.26Interaction between phenytoin and valproate. ( Beran, RC; Sansom, LN; Schapel, GJ, 1980)
" VPA was excreted in the neonates with a mean half-life of 47 +/- 15 hr (n = 8) which is approximately 4 times the mean value found in adult epileptics."1.26Valproic acid and its metabolites: placental transfer, neonatal pharmacokinetics, transfer via mother's milk and clinical status in neonates of epileptic mothers. ( Häuser, I; Helge, H; Koch, S; Nau, H; Rating, D, 1981)
" These side-effects are dose-related, and the daily dosage should never exceed 40 mg/kg."1.26[Sodium valproate, platelet dysfunction and bleeding (author's transl)]. ( Loiseau, P, 1981)
"The Michaelis-Menten pharmacokinetics and bioavailability of phenytoin were evaluated in children."1.26Plasma levels and pharmacokinetics of antipileptic drugs in children. ( Miura, H, 1981)
"The diagnosis of functional seizures is difficult and emotional factors may be important in the cause and triggering of seizures."1.26Differentiating between organic and functional seizures: a common diagnostic problem. ( Chambers, BR; Vajda, FJ, 1981)
"Phenytoin (PHT) binding was also determined for comparison."1.26Diurnal oscillations in plasma protein binding of valproic acid. ( Levy, RH; Ojemann, LM; Patel, IH; Venkataramanan, R; Viswanathan, CT, 1982)
" Reducing the dosage by 19 mg/kg (A to B) decreased VPA plasma levels by 6."1.26Monitoring free valproic acid in epilepsy patients medicated with coanticonvulsants. ( Haidukewych, D; Rodin, EA, 1982)
"A Consensus Development Conference on Febrile Seizures was held at the National Institutes of Health in USA in May 1980."1.26["Fever convulsions" in children. Current viewpoints on diagnosis, therapy and prognosis]. ( Helwig, H; Staudt, F, 1982)
"Results of clinical and pharmacokinetic observations on sodium valproate (VPA) are reported from a long-term study in 100 children with epilepsy."1.26Clinical and pharmacokinetic observations on sodium valproate - a 5-year follow-up study in 100 children with epilepsy. ( Henriksen, O; Johannessen, SI, 1982)
"Sixty-five children with seizure disorders, who had been treated with multiple anticonvulsants but were poorly controlled, were selected from the Montreal Children's Hospital Convulsive Disorder Clinic and Neurology Service and were treated with sodium valproate (valproate)."1.26Sodium valproate in the treatment of the intractable childhood epileptic. ( Keene, DL; Metrakos, K; Sherwin, A; Watters, GV, 1982)
"1 The fluctuations in protein binding of sodium valproate during one dosing interval were studied in five patients stabilized on valproate and taking concurrent anticonvulsant therapy."1.26Intra-dose variation in plasma protein binding of sodium valproate in epileptic patients. ( Kilpatrick, CJ; Marty, JJ; Moulds, RF, 1982)
"Only 21% of those with myoclonic astatic epilepsy have become free from seizures."1.26Sodium valproate: monotherapy and polytherapy. ( Covanis, A; Gupta, AK; Jeavons, PM, 1982)
"Since epilepsy is a long-standing condition lasting for years to decades, short-spanned cross-sectional observations are often misleading."1.26Therapeutic concentration of antiepileptic drugs and the severity of epileptogenesis. ( Kakegawa, N; Seino, M, 1982)
"7 cases of stuporous states or coma induced in epileptic subjects by the rapid administration of high doses of sodium valproate are described."1.26Stuporous states or coma induced by the rapid administration of high doses of sodium valproate. ( Gastaut, H; Iemolo, F, 1982)
" The bioavailability appeared to be the same for all the forms."1.26Comparison of the effectiveness of several formulations of sodium valproate: tablets, enteric-coated capsules, solutions and rectal capsules. ( Avanzini, G; Battino, D; Biraghi, M; Cusi, C; Nespolo, A, 1982)
" The drug was absorbed and excreted rapidly; the mean half-life was 9."1.26Sodium valproate: pharmacokinetics and effectivensss in treating intractable seizures. ( Dreifuss, FE; Kupferberg, HJ; Penry, JK; Redenbaugh, JE; Sato, S, 1980)
" The following results were found while DPA was administered in a relatively high dosage with a mean of 48 mg/kg body weight/day and ranging from 7 to 125 mg/kg/day."1.26Treatment of childhood epilepsy with dipropylacetic acid (DPA). ( Blaschke, E; Fehr, R; Lagenstein, I; Rothe, M; Sternowsky, HJ, 1978)
" A twice daily dosage regime was satisfactory."1.26Sodium valproate (Epilim) in epilepsy: a trial. ( Briant, RH; Foote, SE; Wallis, WE, 1978)
"Valproic acid is a new antiepileptic drug recently introduced in the United States for the treatment of absence seizures."1.26Clinical efficacy of valproic acid in relation to plasma levels. ( Bruni, J; Crawford, LE; Thomas, M; Villarreal, HJ; Wilder, BJ; Willmore, LJ, 1978)
" DPA was eliminated with a half-life of 7."1.26Pharmacokinetic studies with valproic acid in man. ( Klotz, U, 1977)
"Valproic acid assay was performed by gas-liquid chromatography."1.26Steady-state kinetics of valproic acid in epileptic patients. ( Bruni, J; Perchalski, RJ; Villarreal, HJ; Wilder, BJ; Willmore, LJ, 1978)
" 4) Dosage and plasma levels did not appear to show a close correlation."1.26Plasma sodium valproate levels and clinical response in epilepsy. ( Anthony, M; Hinterberger, H; Lance, JW, 1977)
"Carbamazepine has recently been introduced for the treatment of generalized tonic-clonic and partial seizures."1.26Recent advances in drug therapy for epilepsy. ( Bruni, J, 1979)
" The abnormal values returned promptly to normal when the drug therapy was discontinued or the dosage reduced."1.26A direct hepatotoxic effect of valproic acid. ( McLain, LW; Sussman, NM, 1979)
"Hyperglycinemia was induced by dipropylacetate (DPA) (dose 14-41 mg/kg per day) in 10 Finnish epileptic patients with neurologically disabling diseases of various kinds."1.26Dipropylacetate and hyperglycinemia. ( Huhtaniemi, I; Linna, SL; Saukkonen, AL; Similä, S; von Wendt, L, 1979)
" The results indicate that a proportional rise in plasma sodium valproate levels can be expected following dosage increments in an individual patient."1.26Sodium valproate: dose-plasma level relationships and interdose fluctuations. ( Bladin, PF; Mihaly, GW; Miles, JL; Morris, PM; Vajda, FJ, 1978)
" Dosage varied from 23 to 54mg/kg and twice-daily administration was usual."1.26Treatment of generalized epilepsies of childhood and adolescence with sodium valproate ("epilim"). ( Clark, JE; Jeavons, PM; Maheshwari, MC, 1977)
"79 patients with primary generalized epilepsies have been treated with DPA in a medium dosage of 51 mg/kg bodyweight/day, range 14 to 125 mg/kg/day, for a medium time of 22 months, range 2 to 49 months."1.26[The treatment of primary generalized epilepsies with dipropyl acetate (DPA)]. ( Blaschke-Zimmermann, E; Fehr, R; Iffland, E; Lagenstein, I; Sternowsky, HJ, 1977)
" In rather short time reliable information concerning indication, compatibility and dosage can be received."1.26[Austrian complex-study on dipropylacetate. Pediatric experiences]. ( Groh, Ch; Rosenmayr, FW, 1976)

Research

Studies (2,662)

TimeframeStudies, this research(%)All Research%
pre-1990593 (22.28)18.7374
1990's447 (16.79)18.2507
2000's664 (24.94)29.6817
2010's666 (25.02)24.3611
2020's292 (10.97)2.80

Authors

AuthorsStudies
Conley, JD1
Kohn, H1
Flaherty, PT1
Greenwood, TD1
Manheim, AL1
Wolfe, JF1
Pessah, N2
Bialer, M15
Wlodarczyk, B2
Finnell, RH2
Yagen, B6
Azam, F1
El-Gnidi, BA1
Alkskas, IA1
McComsey, DF1
Smith-Swintosky, VL1
Parker, MH1
Brenneman, DE1
Malatynska, E1
White, HS3
Klein, BD1
Wilcox, KS1
Milewski, ME1
Herb, M1
Finley, MF1
Liu, Y3
Lubin, ML1
Qin, N1
Reitz, AB1
Maryanoff, BE2
Kumari, S2
Mishra, CB1
Tiwari, M1
Chen, L5
Xu, Z2
Huang, H1
Ahmad, S2
Aamir, M1
Kirmani, SI1
Haroon, ZH1
Munir, MU1
Khalid, UB1
Liu, CH2
Liao, WC2
Li, HH2
Tseng, LH2
Wang, WH2
Tung, H2
Lin, PJ2
Jao, HT1
Liu, WY2
Hung, CS2
Lin, CL2
Ho, YJ2
Müffelmann, B1
Hagemann, A1
Knaak, N1
Bien, CG1
Cunningham, D1
Clark, K1
Lord, K1
Minshall, I1
Buckels, L1
Cox, P1
Jamroze, H1
Jeyam, T1
Newman, A1
Williams, L1
Neligan, A1
Mani, B1
Nair, PP1
Sekhar, A1
Kamalanathan, S1
Narayan, SK2
Kesavan, R2
Kaplan, AT1
Oskan Yalcın, S1
Sager, SG1
Muthaffar, OY1
Almahmudi, SM1
Alrabghi, MO1
Bin Mahfouz, MM1
Alfawaz, NS1
Kurishima, A1
Hayashi, M1
Shimozato, R1
Isozaki, R1
Shioda, T1
Iijima, A1
Yang, Y2
Zeng, Q1
Cheng, M2
Niu, X1
Xiangwei, W1
Gong, P1
Li, W2
Ma, J1
Zhang, X5
Yang, X6
Yang, Z1
Sun, D1
Zhou, S4
Liao, J1
Jiang, Y4
Zhang, Y15
Labh, R1
Gupta, R1
Narang, M1
Halder, S1
Kar, R1
Rochtus, AM1
Herijgers, D1
Jansen, K1
Decallonne, B1
Rakitin, A4
Kurvits, K1
Laius, O1
Uusküla, M1
Haldre, S4
Lan, X1
Mo, K1
Nong, L1
He, Y2
Sun, Y8
Hsieh, TC1
Lin, CC1
Wu, LS1
Wang, L8
Li, H11
Zeng, G1
Shi, L3
Zhu, M3
Luo, J4
Zhang, Z3
Hernández-Ramos, JA1
Caro-Telle, JM1
Bruni-Montero, MÁ1
Canales-Siguero, D1
Ferrari-Piquero, JM1
Bisi-Onyemaechi, AI1
Chikani, UN1
Uwaezuoke, NA1
Aronu, AE1
Ojinnaka, NC1
Degremont, A1
Polard, E2
Kerbrat, S1
Grimaud, O1
Jonville-Béra, AP1
Ringa, V1
Travers, D1
Oger, E1
Biraben, A4
Nowak, E1
Nasreddine, W4
Atweh, SF1
Beydoun, AA1
Dirani, M2
Nawfal, O1
Beydoun, A5
Martin, M2
Hill, C1
Bewley, S2
MacLennan, AH1
Braillon, A3
Gong, X1
Liu, X5
Li, AQ1
Guo, KD1
Zhou, D9
Hong, Z4
Widatalla, N1
Khandoker, A1
Yoshida, C1
Nakanishi, K1
Fukase, M1
Suzuki, A3
Kasahara, Y1
Saito, M4
Kimura, Y2
Ilia, TS1
Dragoumi, P1
Papanikolopoulou, S1
Goulis, DG1
Pavlou, E2
Zafeiriou, D1
Marson, AG19
Burnside, G1
Appleton, R2
Smith, D2
Leach, JP3
Sills, G1
Tudur-Smith, C2
Plumpton, CO1
Hughes, DA1
Williamson, PR7
Baker, G3
Balabanova, S1
Taylor, C1
Brown, R1
Hindley, D1
Howell, S2
Maguire, M4
Mohanraj, R2
Smith, PE2
Zhu, Y1
Yang, J3
Zhu, X2
Zelano, J3
Sveberg, L1
Taubøll, E13
Tomson, T27
Mishra, MK1
Kukal, S6
Paul, PR4
Bora, S4
Singh, A4
Kukreti, S4
Saso, L2
Muthusamy, K1
Hasija, Y1
Kukreti, R7
Yıldız, A1
Vardı, N1
Parlakpınar, H1
Ateş, B1
Çolakoğlu, N1
Gaudio, M1
Konstantara, E1
Joy, M1
van Vlymen, J1
de Lusignan, S1
He, J1
Wu, X9
Błaszczyk, B1
Miziak, B1
Pluta, R1
Czuczwar, SJ7
Vajda, FJE7
O'Brien, TJ25
Graham, JE6
Hitchcock, AE1
Perucca, P4
Lander, CM15
Eadie, MJ23
Heger, K2
Skipsfjord, J1
Kiselev, Y1
Burns, ML4
Aaberg, KM1
Johannessen, SI9
Skurtveit, S1
Johannessen Landmark, C4
Terman, SW1
Youngerman, BE1
Choi, H2
Burke, JF1
Hochbaum, M1
Kienitz, R2
Rosenow, F10
Schulz, J1
Habermehl, L1
Langenbruch, L1
Kovac, S5
Knake, S8
von Podewils, F6
von Brauchitsch, S1
Hamacher, M1
Strzelczyk, A7
Willems, LM2
Sturla Álvarez, DA1
Sánchez Marcos, E1
de Lucas Collantes, C1
Cantarín Extremera, V1
Soto Insuga, V1
Aparicio López, C1
Eriksson, SH1
Tittensor, P1
Sisodiya, SM3
Wu, H3
Liu, J3
Qian, F1
Wang, Y19
Guan, S1
Kessing, LV1
Ziersen, SC1
Gerds, T1
Budtz-Jørgensen, E1
Kikuchi, D1
Obara, T1
Miura, R1
Suzuki, N1
Josaka, R1
Tokunaga, M1
Ouchi, R1
Usui, K1
Okada, K1
Zang, YN1
Guo, W1
Dong, F1
Li, AN1
de Leon, J1
Ruan, CJ1
Kowalski, TW1
Lord, VO1
Sgarioni, E1
Gomes, JDA1
Mariath, LM1
Recamonde-Mendoza, M1
Vianna, FSL1
Yang, H4
Liao, H2
Gan, S1
Xiao, T1
Wu, L3
Bjørk, MH7
Zoega, H5
Leinonen, MK5
Cohen, JM5
Dreier, JW5
Furu, K5
Gilhus, NE4
Gissler, M5
Hálfdánarson, Ó1
Igland, J2
Alvestad, S5
Christensen, J9
Menkes, DB1
Goldspink, R1
Han, Y1
Zhong, R1
Guo, X1
Cai, M2
Lin, W4
Ju, Y1
Ji, TY1
Mahmoud, AA1
Aboelghar, HM1
Abdelmageed, SM1
Abdallah, HM1
Garib, MI1
Abd El Hady, NMS1
La Neve, A3
Falcicchio, G1
Trojano, M1
Boero, G1
Mishra, S1
Mishra, D2
Mahajan, B1
Mantan, M1
Khan, AM1
Rzayev, E1
Amanvermez, R1
Gün, S1
Tiryaki, ES1
Arslan, G1
Thomas, SV7
Jeemon, P1
Jose, M3
Amrithum, LM1
Bhaskar, D1
Nair, MKC1
George, B1
Chen, Y15
Chen, J9
Zhuang, X1
Chen, X7
Zeng, J1
Wang, R1
Miao, J2
Yang, Q1
Hu, Y6
Dai, H2
Li, X12
Kong, ST4
Lin, HS1
Ching, J1
Xie, H1
Ho, PC4
Guo, HL2
Dong, N1
Chen, F3
Zeng, YY1
Hu, YH2
Xia, Y1
Tian, M1
Lu, XP3
Qiu, JC2
Winter, Y1
Uphaus, T1
Sandner, K1
Klimpe, S1
Stuckrad-Barre, SV1
Groppa, S1
van der Meer, PB1
Taphoorn, MJB1
Koekkoek, JAF1
Panda, SP1
Dhurandhar, Y1
Agrawal, M1
Zorina, VN1
Bespalov, AY1
Krasnov, KA1
Melekhova, AS1
Reinuk, VL1
Bobylova, MY1
Mukhin, KY1
Kuzmich, GV1
Glukhova, LY1
Pylayeva, OA1
Vakrinou, A1
Murphy, E2
Vivekananda, U1
Balestrini, S1
Szczygieł-Pilut, EE1
Zajączkowska-Dutkiewicz, A1
Pilut, D1
Dutkiewicz, J1
Ascoli, M1
Elia, M2
Gasparini, S1
Bonanni, P2
Mastroianni, G1
Cianci, V1
Neri, S1
Pascarella, A1
Santangelo, D1
Aguglia, U3
Ferlazzo, E1
Gruppuso, PA1
Ahmed, R1
Adashi, EY1
Gebauer-Bukurov, K1
Sekulić, S1
Živanović, Ž1
Nikolašević, Ž1
Tekin, U2
Tekin, E1
Uçar, HN1
Nicolo, JP1
Chen, Z10
Nightscales, R1
Kwan, P7
Zhang, D1
Mei, S3
Zhao, Z4
Pang, W1
Lu, S1
Zheng, R2
Yang, S2
Feng, Y1
Wang, S3
Guo, J1
Shi, X2
Song, C3
Zhao, J1
Xia, L3
Ma, L3
Jiang, W2
Gremke, N1
Printz, M1
Möller, L1
Ehrenberg, C1
Kostev, K4
Kalder, M1
Jiménez, M1
Grau-López, L1
Ciurans, J1
García-Esperón, C1
Fumanal, A1
Barambio, S1
Chíes, E1
Codina, M2
Becerra, JL1
Dell'Isola, GB1
Mencaroni, E1
Prontera, P1
Cara, GD1
Ferraro, L1
Carotenuto, M1
Iapadre, G1
Matricardi, S1
Operto, F1
Orsini, A1
Parisi, P5
Pavone, P1
Salpietro, V1
Savasta, S1
Striano, P6
Verrotti, A35
Battino, D14
Bromley, R3
Kochen, S1
Meador, KJ17
Pennell, PB8
Samadianzakaria, A1
Abdolmaleki, Z1
Faedmaleki, F1
Soto-Insuga, V2
González-Alguacil, E2
García-Peñas, JJ2
Li, Y8
Myren-Svelstad, S1
Jamali, A1
Ophus, SS1
D'gama, PP1
Ostenrath, AM1
Mutlu, AK1
Hoffshagen, HH1
Hotz, AL1
Neuhauss, SCF1
Jurisch-Yaksi, N1
Yaksi, E1
Borowicz-Reutt, K1
Banach, M3
Singh, S2
Singh, TG1
Yi, Z1
Song, Z1
Xue, J1
Yang, C2
Li, F1
Pan, H2
Feng, X1
Andrade, C1
Zhang, H2
Bao, J1
Lu, W3
Peng, Q4
Kuanyshbek, A1
Wang, M5
Andersson, Å1
Tuifua, M1
Palmer, EE1
Sachdev, RK1
Mu, TW1
Vetter, I1
Keramidas, A1
Bleakley, LE1
McKenzie, CE1
Reid, CA1
Omefe, PN1
N Adeboye, MA1
Biliaminu, SA1
Ojuawo, A1
George, LJ1
Singh, P4
Aneja, S4
Singh, R1
Solanki, RS1
Seth, A1
Wang, G3
Lu, J4
Li, Z7
Heydari, FS3
Gorji Valokola, M3
Mehri, S3
Abnous, K3
Roohbakhsh, A3
Kanojia, N3
Rawat, C5
Sagar, S3
Bhatraju, NK3
Grewal, GK3
Satyamoorthy, K3
Mann, C3
Maltseva, M3
Cesta, CE3
Nørgaard, M3
Einarsdóttir, K3
Engeland, A3
Karlstad, Ø3
Klungsøyr, K3
Odsbu, I3
Reutfors, J3
Selmer, RM3
Ulrichsen, SP3
Hosseini, H3
Shafie, M3
Shakiba, A3
Ghayyem, H3
Mayeli, M3
Hassani, M3
Aghamollaii, V3
Maghbooli, M2
Jourahmad, Z2
Golizadeh, M2
Ayala-Guerrero, F2
Castro-Domínguez, D2
Mateos-Salgado, EL2
Mexicano-Medina, G2
Gutiérrez-Chávez, CA2
Jiang, Z3
Ling, J2
Dong, L2
Zou, S2
Chen, R2
Hu, N2
Delage, C2
Palayer, M2
Etain, B2
Hagenimana, M2
Blaise, N2
Smati, J2
Chouchana, M2
Bloch, V2
Besson, VC2
Anguissola, G1
Leu, D1
Simonetti, GD1
Simonetti, BG1
Lava, SAG1
Milani, GP1
Bianchetti, MG1
Scoglio, M1
Wójcik, K1
Franciszek Kołek, M1
Dec-Ćwiek, M1
Słowik, A2
Bosak, M4
Leuschner, UV1
Kleinle, S1
Holzinger, A1
Neef, J1
Marson, T1
Zheng, XX1
You, YX1
Zhao, LL1
Du, Y3
Xu, SQ1
Tang, DQ1
Di Vito, L1
Mazzoni, S1
Belotti, LMB1
Poluzzi, E1
Baldin, E1
Zenesini, C2
Bisulli, F2
Tinuper, P2
Mostacci, B3
Bertoncello, KT2
Bonan, CD2
van Haaren, PCF1
Bloemkolk, D1
Rundervoort, RS1
Gerritse, FL1
Li, J5
Sha, L1
Xu, Q4
Aronica, E1
Ciusani, E1
Coppola, A2
Costa, C5
Russo, E5
Salmaggi, A1
Perversi, F1
Maschio, M2
Diederich, S1
Hemmeter, U1
Paulmann, M1
Mockenhaupt, M2
Xie, Z1
Yin, J1
Fan, X3
Yu, J2
Wang, D1
Yu, M1
Dubbioso, R1
Cuccurullo, C1
Licchetta, L1
Carreno, M1
Hirsch, E2
Bilo, L6
Armeno, ML1
Kossoff, EH2
Dongxiao, QU1
Yiqin, GE1
Limin, Z1
Liji, C1
Yonghua, X1
Jiwei, C1
Jie, T1
Guoyi, LI1
Yudan, Z1
Qian, X1
Hersi, H2
Raitanen, J2
Saarinen, JT2
Peltola, J3
Lahmini, W1
Gyamfi, SO1
Bourrous, M2
Jin, K1
Zhou, SM1
McLean, B1
Roberts, E1
Baines, R1
Hannon, P1
Ashby, S1
Newman, C1
Sen, A2
Wilkinson, E1
Laugharne, R1
Shankar, R4
Ishikawa, M1
Uchida, M2
Asakawa, T1
Suzuki, S1
Yamazaki, S4
Shiko, Y1
Kawasaki, Y2
Suzuki, T2
Ishii, I1
Håkansson, S1
Wickström, R1
Zhan, H1
Wu, J3
Cao, G2
Guo, B1
Fan, Y1
Hu, J1
Xu, X3
Yu, P2
Zhang, J5
Pavuluri, H1
Fasaludeen, A1
Sundaram, S1
Radhakrishnan, A1
Banerjee, M1
Menon, RN1
Peng, X1
Muller, AL1
Diaz-Arias, L1
Cervenka, MC1
McDonald, TJW1
Yanaga, M1
Okamoto, N2
Hashimoto, R1
Igata, R1
Konishi, Y1
Ikenouchi, A1
Isomoto, N1
Shinkai, T1
Harada, M1
Yoshimura, R1
Jomaa, N1
Hmeimess, G1
Beaini, S1
Hotait, M1
Wazne, J1
van der Goten, M1
Zöllner, JP2
Lopez, MR1
VanCott, AC1
Amuan, ME1
Panahi, S1
Henion, A1
Pugh, MJ1
Lekhwani, S1
Dhama, A1
Kaushik, JS2
Božina, N3
Sporiš, IŠ1
Domjanović, IK1
Ganoci, L2
Šimičević, L1
Lovrić, M3
Romić, ZČ1
Gadže, ŽP1
Trkulja, V2
Pekoz, MT1
Aslan-Kara, K1
Tekin, B1
Gurses, C1
Yeni, SN1
Bozdemir, H1
Keskin-Guler, S1
Ataklı, D2
Gul, G1
Eren, F1
Sarı, H1
Gul, ZB1
Ceyhan-Dirican, A1
Genc, F1
Bicer-Gomceli, Y1
Ozkara, C5
Delil, S1
Atalar, AC2
Bebek, N2
Baykan, B2
Bora, İ2
Bican-Demir, A1
Mısırlı, CH1
Tutkavul, K1
Velioglu, SK1
Ilhan-Algin, D1
Erdinc, O1
Saygi, S1
Tezer-Fılık, I1
Apaydın-Dogan, E1
Akyol, A1
Kamisli, O1
Yalcın, AD1
Cakmak, G1
Ersoy, A1
Ustun-Ozek, S1
Halac, G1
Kutlu, G2
Tantik-Pak, A1
Yücel, SP1
Lawal, OD1
Hume, AL1
Wen, X3
Zhu, J1
Shen, X1
Xia, H1
Guo, H2
Scholz, K1
Köster, I1
Meyer, I1
Selke, GW1
Schubert, I1
Lesné, L1
Desdoits-Lethimonier, C1
Hug, E1
Costet, N1
Raffenne, L1
Toupin, M1
Evrard, B1
Kugathas, I1
Lavoué, V1
Chalmel, F1
Jégou, B1
Mazaud-Guittot, S1
McCarron, EP1
Umlauf, J1
Rau, A1
Demerath, T1
Bast, T1
Schönberger, J1
Urbach, H1
Jacobs, J1
Klotz, KA1
Wang, J6
Huang, P1
Yu, Q1
Liu, P1
Feng, Z1
Cai, J1
Yang, G1
Yuan, H1
Tang, H2
Lu, Y4
Hope, OA1
Harris, KM1
Iwasaki, M1
Chand, P1
Angez, M1
Hameed, AN1
Kirmani, S1
Kwack, DW1
Kim, DW1
Zhu, R1
Wang, Q6
Zhou, Y7
Shi, W1
Zhao, R1
Aricò, M1
Mastrangelo, M2
Di Noia, SP1
Mabusi, MS1
Kalolo, A1
Pisani, F11
Tsyvunin, V1
Shtrygol, S1
Mishchenko, M1
Lytkin, D1
Taran, A1
Shtrygol, D1
Gorbach, T1
Ordoño-Saiz, MV1
Púa-Torrejón, RC1
Justel-Rodríguez, M1
Arias-Vivas, E1
Heppe-Montero, M1
Duat-Rodríguez, A1
Ruiz-Falcó-Rojas, ML1
Gutiérrez-Delicado, E1
Ramakrishnan, K1
Venkatraman, S1
Kumar, RR1
Shewade, D1
Daniels, SD1
Boison, D1
Saleh Faisal, M1
Jamil, A1
Ali, N2
Alshahrani, AM1
Almarshad, F1
Vajda, F9
O'Brien, T3
Graham, J15
Hitchcock, A7
Lander, C5
Eadie, M4
Fantaneanu, TA1
Thornton, HF1
Zhang, T5
Bercovici, E1
Hrazdil, C1
Ikeda, KM1
Kassiri, J1
Suller Marti, A1
Pana, R1
Rezazadeh, A1
Kobayashi, E1
Bui, E1
Bakri, AH1
Meki, AMA1
Nassar, AY1
Hassan, MH1
Ellisy, RAM1
Radwan, E1
Ameen, HH1
Nasser, SA1
Abd-Elmawgood, EA1
Abid, M1
Basit, A1
Yang, D1
Zhao, D1
Li, N1
Fu, J2
Peng, L4
Tao, T2
Charlton, R1
Damase-Michel, C1
Hurault-Delarue, C1
Gini, R1
Loane, M2
Pierini, A1
Puccini, A2
Neville, A2
Snowball, J1
Morris, JK2
Jackson, A1
Ward, H1
Bromley, RL7
Deshpande, C1
Vasudevan, P1
Scurr, I1
Dean, J1
Shannon, N1
Berg, J1
Holder, S1
Baralle, D1
Clayton-Smith, J12
Kushwaha, S2
Agarwal, R1
Sharma, S6
Srivastava, AK3
Kamiński, K1
Socała, K2
Zagaja, M3
Andres-Mach, M2
Abram, M1
Jakubiec, M1
Pieróg, M1
Nieoczym, D2
Rapacz, A1
Gawel, K1
Esguerra, CV1
Latacz, G1
Lubelska, A1
Szulczyk, B2
Szewczyk, A1
Łuszczki, JJ4
Wlaź, P3
De Caro, C2
Leo, A2
Nesci, V2
Ghelardini, C1
di Cesare Mannelli, L1
Avagliano, C1
Calignano, A2
Mainardi, P1
Constanti, A1
Citraro, R2
De Sarro, G4
Revilla Orías, MD1
Alonso, X1
Campistol, J3
Macaya, A1
Escofet, C1
Fons, C1
Gu, X3
Yu, S2
Ma, M3
Zhou, B4
Calle-Lopez, Y1
Kotagal, P1
Knight, EP1
Aykan, DA1
Ergün, Y1
Osina, G1
Rider, F1
Guekht, A1
Han, X4
Yamamoto, Y7
Takahashi, Y7
Imai, K6
Ohta, A1
Kagawa, Y4
Inoue, Y8
Meenu, M1
Reeta, KH3
Dinda, AK1
Kottarath, SK1
Gupta, YK10
Liguori, C2
Franchini, F1
Izzi, F2
Spanetta, M1
Cesarini, EN1
Di Santo, S1
Manfredi, N1
Farotti, L1
Romoli, M3
Lanari, A1
Salvadori, N1
Parnetti, L1
Calabresi, P6
Mercuri, NB2
Placidi, F4
Fan, D1
Sun, M2
Pepi, C1
Cesaroni, E1
Maiorani, D1
Pruna, D1
Cossu, S1
Di Capua, M1
Vigevano, F3
Specchio, N3
Cusmai, R1
Chatterjee, T1
Das, G1
Chatterjee, BK1
Dhar, J1
Ghosh, S2
Chakrabarti, P1
Karatoprak, E1
Tosun, O1
Khakwani, A1
Gannon, D1
Husebye, ESN1
Spigset, O1
Daltveit, AK3
Velghe, S1
Delahaye, L1
Ogwang, R1
Hotterbeekx, A1
Colebunders, R1
Mandro, M1
Idro, R1
Stove, CP1
Kano, Y1
Oguri, T1
Sugiyama, H1
Kikui, S1
Takeshima, T1
Yuasa, H1
Harris, L1
Lowes, O1
Angus-Leppan, H7
Watkins, LV2
Arfman, IJ1
Wammes-van der Heijden, EA1
Ter Horst, PGJ1
Lambrechts, DA1
Wegner, I1
Touw, DJ2
Sharma, NK1
Kaur, S1
Goel, RK5
Asoğlu, R1
Özdemir, M1
Aladağ, N1
Asoğlu, E1
Gasser, M1
Boonsimma, P1
Netbaramee, W1
Wechapinan, T1
Srichomthomg, C1
Ittiwut, C1
Krenn, M2
Zimprich, F2
Milenkovic, I1
Abicht, A1
Biskup, S1
Roser, T1
Shotelersuk, V1
Tacke, M1
Kuersten, M1
Wagner, M1
Borggraefe, I1
Suphapeetiporn, K1
von Stülpnagel, C1
Kodama, M1
Higuchi, H1
Ishii-Maruhama, M1
Nakano, M1
Honda-Wakasugi, Y1
Maeda, S1
Miyawaki, T1
Kutum, R1
Srivastava, A1
Dahiya, UR1
Dash, D1
Demir, UF1
Lattanzi, S1
Brigo, F1
Zaccara, G8
Moghim, MM1
Cock, H2
Kinton, L1
Synnott Wells, M1
Tao, S1
Sun, J2
Hao, F1
Tang, W2
Guo, D1
Zhao, M6
Li, G5
Zhao, L13
Kumar, S2
Sarangi, SC4
Tripathi, M5
Min, L1
Chunyan, W1
Biaoxue, R1
Wolking, S1
Moreau, C1
Nies, AT1
Schaeffeler, E1
McCormack, M1
Auce, P1
Avbersek, A1
Becker, F1
Møller, RS1
Nikanorova, M1
Weber, YG1
Weckhuysen, S1
Cavalleri, GL2
Delanty, N4
Depondt, C1
Johnson, MR2
Koeleman, BPC1
Kunz, WS2
Sander, JW7
Sills, GJ4
Zara, F1
Schwab, M1
Krause, R1
Cossette, P1
Girard, SL1
Lerche, H1
Choi, SA1
Kim, H2
Kim, S1
Yoo, S1
Yi, S1
Jeon, Y1
Hwang, H2
Kim, KJ3
Su, Q3
Li, M1
Dayimu, A1
Dai, X1
Wang, Z4
Che, F1
Xue, F1
Deng, L1
Ma, A1
Wood, N1
Ardern-Holmes, S1
Diemar, SS1
Sejling, AS1
Eiken, P1
Ellegaard, M1
Ding, M2
Andersen, NB1
Jørgensen, NR1
Toledo, M2
Jedrzejzak, J1
Thomas, RH3
Salas-Puig, J2
Schmitz, B4
Cozzolino, O1
Sicca, F1
Paoli, E1
Trovato, F1
Santorelli, FM1
Ratto, GM1
Marchese, M1
Tayama, T1
Mori, T2
Goji, A2
Toda, Y2
Kagami, S2
Hu, W1
Puig-Molto, M1
Pol-Yanguas, E2
Segarra, L1
Lumbreras, B1
Hitchcock, AA6
Caraballo, RH1
Pociecha, J1
Reyes, G1
Espeche, A1
Galichio, S1
Fasulo, L1
Semprino, M1
Myers, KA1
Tamon, U1
Agnihotram, RV1
Berrahmoune, S1
Ben-Menachem, E3
Gunning, B1
Arenas Cabrera, CM1
VanLandingham, K1
Crockett, J1
Critchley, D1
Wray, L1
Tayo, B1
Morrison, G1
Altun, Y1
Yasar, E1
Gerstner, TA1
Davies, P2
Reuber, M5
Grunewald, R1
Dickson, J1
Dennis, G1
Shanmugarajah, P1
Tsironis, T1
Brockington, A1
Yoon, HY1
Ahn, MH1
Yee, J1
Lee, N2
Han, JM1
Gwak, HS1
Elgarhi, R1
Shehata, MM1
Abdelsameea, AA1
Salem, AE1
Calabrò, RS1
Yokoyama, S3
Yasui-Furukori, N4
Nakagami, T1
Miyazaki, K1
Ishioka, M1
Tarakita, N1
Kubo, K1
Sugawara, N1
Shimoda, K1
Tao, J1
Hu, L2
Li, Q5
Kondrat-Wróbel, M1
Karwan, S1
Bojar, H1
Plewa, Z1
Florek-Łuszczki, M1
Limotai, C1
Phayaph, N1
Pattanasilp, B1
Mokklaew, J1
Limotai, N1
Chávez-Castillo, CE1
Medellín-Garibay, SE1
Milán-Segovia, RDC1
Rodríguez-Leyva, I1
Romano-Moreno, S1
Velken, T1
Lund, C1
Bjørnvold, M1
Sætre, E1
Morrison, I1
Cork, H1
Smith, P1
Campbell, C1
Megan McTiernan, M1
White, K2
Ho, PH1
Leung, WCY1
Leung, IYH1
Chang, RSK1
McNamara, NA1
Dang, LT1
Sturza, J1
Ziobro, JM1
Fedak Romanowski, EM1
Smith, GC1
Joshi, SM1
Leber, SM1
Carlson, M1
Robertson, P1
Shellhaas, RA1
Wang, CY2
Jiao, Z4
Ding, JJ1
Yu, EQ1
Zhu, GX2
Ilieva, HS1
Newman, JW1
Fields, RK1
Croom, JE1
Devries, S1
Mulder, M1
Charron, JG1
Prokop, JW1
Mark, PR1
Janković, SM5
Janković, SV2
Noguchi, Y1
Takaoka, M1
Hayashi, T5
Tachi, T1
Teramachi, H1
Esmael, A1
Elsherief, M1
Abdelsalam, M1
Bendary, L1
Egila, H1
Söylemez, E1
Öztürk, O1
Baslo, SA1
Balçık, ZE1
Karlov, VA7
Kozhokaru, AB2
Vlasov, PN5
Pushkar, TN1
Orlova, AS1
Watkins, L1
Perera, B1
Courtenay, K1
Banks, R1
Mehta, U1
Smith, M1
Kalk, E1
Hayes, H1
Swart, A1
Tucker, L1
Coetzee, R1
Boulle, A1
Blockman, M1
Jia, W1
Song, Y2
Yang, L3
Kong, J1
Boczek, T1
He, Z1
Hu, H1
Shao, D1
Guo, F1
Mao, P1
Song, W1
Liu, L4
Tseng, YJ1
Huang, SY1
Kuo, CH1
Wang, KC1
Wu, CC1
Wang, P5
Pan, J2
Wang, C5
Ma, H3
Samanta, D1
Yu, L4
Feng, J1
Yu, Z1
Quílez, A1
Baraldés-Rovira, M1
Gallego, Y1
Sanahuja, J1
Mauri-Capdevila, G1
Purroy, F1
Furugen, A1
Robson, J1
Moss, N1
McGettigan, P1
Beardsley, SJ1
Lovegrove, E1
Dezateux, C1
Miyata-Nozaka, Y1
Tan, HJ5
Wong, SW4
Raymond, AA5
Omar, H2
Zain, SM1
Coste, J1
Blotiere, PO1
Miranda, S1
Mikaeloff, Y2
Peyre, H1
Ramus, F1
Zureik, M1
Weill, A1
Dray-Spira, R1
Liu, M4
Mao, J1
Xu, H3
Zhao, P2
Du, Z3
Stritzelberger, J1
Lainer, J1
Gollwitzer, S1
Graf, W3
Jost, T1
Lang, JD1
Mueller, TM1
Schwab, S2
Fietkau, R1
Hamer, HM5
Distel, L1
Wiggs, KK1
Rickert, ME1
Sujan, AC1
Quinn, PD1
Larsson, H1
Lichtenstein, P1
Oberg, AS1
D'Onofrio, BM1
Colijn, MA1
Daugaard, CA2
Pedersen, L2
Paparella, G1
Angelini, L1
De Biase, A1
Cannavacciuolo, A1
Colella, D1
Di Bonaventura, C2
Giallonardo, AT1
Berardelli, A1
Bologna, M1
Guo, Y7
Lin, Z1
Huang, Y1
Şimşek, F2
Ceylan, M1
Kızıltunç, A1
İyigün, İ1
Markoula, S3
Siarava, E2
Keramida, A1
Chatzistefanidis, D1
Zikopoulos, A2
Kyritsis, AP1
Georgiou, I2
Okhremchuk, LV1
Seminskii, IZ1
Darenskaya, MA1
Grebenkina, LA1
Kolesnikova, LI1
Kolesnikov, SI1
Kopel, J1
Grooms, A1
Ganapathy, V1
Clothier, J1
Batchelor, H1
Kostoulas, C1
Han, SH1
Lee, H1
Shin, JY1
Moon, HJ1
Lee, SY2
Sheng, C1
Kumar, R2
Arora, R1
Ganeshan N, S1
Agarwal, A1
Kaleekal, T4
Borowicz-Reutt, KK2
Andersson, K1
Ozanne, A1
Bolin, K2
Honybun, E1
Thwaites, R1
Malpas, CB1
Rayner, G1
Anderson, A1
Kaplan, YC1
Demir, O1
Müller, RM1
Herziger, B1
Jeschke, S1
Neininger, MP2
Bertsche, T2
Bertsche, A2
Kilic, H1
Demirel, A1
Uysal, S1
Sanivarapu, R1
Sharma, R2
Akella, J1
Okumura, A6
Numoto, S4
Iwayama, H3
Azuma, Y3
Kurahashi, H5
Lunke, S1
Maxwell, S1
Khurana, I1
K N, H1
Okabe, J1
Al-Hasani, K1
El-Osta, A1
Seshachala, BB1
Lathikakumari, AM1
Murali, S1
Kumar, AS1
Kakumoto, M1
Shimokawa, K1
Ueshima, S4
Hira, D1
Okano, T1
Operto, FF2
Pastorino, GMG1
Scuoppo, C1
Padovano, C1
Vivenzio, V1
Donadio, S1
Coppola, G10
Şirin, NG1
Steinbart, D1
Gaus, V2
Kowski, AB2
Holtkamp, M2
Wen, Z2
Zhu, B1
Loikas, D1
Linnér, L1
Sundström, A1
Wettermark, B2
von Euler, M2
Asadi-Pooya, AA1
Rostaminejad, M1
Zeraatpisheh, Z1
Mirzaei Damabi, N1
Ajinkya, S1
Fox, J1
Lekoubou, A1
Kang, Q1
Chen, B2
Kuang, X1
Liao, C1
Banawalikar, N1
Adiga, S1
Adiga, U1
Shenoy, V1
Shetty, P1
Shetty, S1
Sharmila, KP1
Al-Rafiah, AR1
Mehdar, KM1
Takizawa, T1
Miyaoka, H2
Zan, X2
Xiong, F1
Nie, X2
Ouerdiene, A1
Messelmani, M1
Derbali, H1
Mansour, M1
Zaouali, J1
Mrissa, N1
Mrissa, R1
Smith, PEM1
Vartzelis, G2
Attilakos, A7
Tsentidis, C2
Kalimeraki, I1
Maritsi, D1
Marmarinos, A1
Garoufi, A7
Wu, D1
Sun, H2
Zhu, Q1
Hakami, T2
Uçan Tokuç, FE1
Fatma, G1
Abidin, E1
Yasemin, GB1
Takagi, M1
Liang, D1
Gardella, E1
Kragholm, K1
Polcwiartek, C1
Sessa, M1
Yang, LP1
Ma, HY2
Ben Mahmoud, L1
Hakim, A1
Ghozzi, H1
Atheymen, R1
Sahnoun, Z1
Zeghal, K1
Sidhu, HS2
Srinivas, R1
Sadhotra, A2
Zuberi, NA1
Baig, M1
Bano, S1
Batool, Z1
Haider, S1
Perveen, T1
Pariente, G1
Leibson, T1
Shulman, T1
Adams-Webber, T1
Barzilay, E1
Nulman, I1
Wallenburg, E1
Klok, B1
de Jong, K1
de Maat, M1
van Erp, N1
Stalpers-Konijnenburg, S1
Essink, G1
van Luin, M1
Haratym-Maj, A1
Rola, R1
Maj, M1
Haratym, J1
Dudra-Jastrzębska, M1
Perucca, E30
Methaneethorn, J1
Gooneratne, IK1
Wimalaratna, M1
Ranaweera, AKP1
Wimalaratna, S1
Cherian, KA1
Legatt, AD1
Doré, M1
San Juan, AE1
Frenette, AJ1
Williamson, D1
Bektaş, G1
Özkan, MU1
Yıldız, EP1
Çalışkan, M1
Özmen, M1
Aydınlı, N1
Berggren, F1
Berling, P1
Morberg, S1
Gauffin, H1
Landtblom, AM1
Gao, W1
Liu, G3
Chen, W4
Heo, G1
Kim, SH5
Chang, MJ1
Palmini, A2
Ferrara, P1
Gatto, A1
Blasi, V1
DI Ruscio, F1
Battaglia, D1
Nevitt, SJ2
Sudell, M2
Weston, J3
Tudur Smith, C4
Chalhub, EG1
Veroniki, AA1
Rios, P1
Cogo, E1
Straus, SE1
Finkelstein, Y1
Kealey, R1
Reynen, E1
Soobiah, C1
Thavorn, K1
Hutton, B1
Hemmelgarn, BR1
Yazdi, F1
D'Souza, J1
MacDonald, H1
Tricco, AC1
Tanaka, T3
Yajima, N1
Kiyoshi, T1
Miura, Y1
Iwama, S1
Feng, W2
Zhu, L4
Yu, Y4
Yang, W2
Gao, B2
Fang, F4
Zhou, H1
Wang, N1
Xu, L2
Huang, HL1
Yu, CY1
Hebert, SA1
Bohan, TP2
Erikson, CL1
Swinford, RD1
Baftiu, A3
Farmen, AH2
Lossius, MI5
Koga, S1
Kimata, T1
Yamanouchi, S1
Tsuji, S2
Yoshimura, K1
Araki, A2
Kaneko, K1
Joshi, D1
Lo Sardo, F1
Muti, P1
Blandino, G1
Strano, S1
Zhu, MM1
Li, HL2
Shi, LH1
Chen, XP2
Zhang, ZL1
Takami, A1
Murotani, K1
Liang, YW1
Feng, Q1
Zhang, YL1
Wang, WJ1
Wise, J1
Ay, H1
Ethemoğlu, Ö1
Zhang, W2
Yan, J1
Wang, B2
Hadzagic-Catibusic, F1
Hasanbegovic, E1
Melunovic, M1
Zubcevic, S1
Uzicanin, S1
Gaddam, M1
Velagapudi, RK1
Abu Sitta, E1
Kanzy, A1
Wiedemann, K1
Stüber, T1
Rehn, M1
Frieauff, E1
Monostory, K3
Nagy, A3
Tóth, K3
Bűdi, T3
Kiss, Á3
Déri, M1
Csukly, G1
Popławska, M1
Srinivasa, R1
Wen, D2
Liu, H4
Dai, Q1
Zhong, G1
Qin, J6
Ni, G5
Huang, M9
Zhou, L8
Wang, X10
Doo, JW1
Kim, SC1
Kim, SJ1
Durá-Travé, T1
Gallinas-Victoriano, F1
Malumbres-Chacón, M1
Moreno-Gónzalez, P1
Aguilera-Albesa, S1
Yoldi-Petri, ME1
Lin, XQ1
Cai, WK1
Xu, GL1
Zhou, MD1
Yang, M1
He, GH1
Kızıltan, ME1
Leba, LK1
Gündüz, A1
Pazarcı, N1
Yeni, N1
Morimoto, M1
Shimakawa, S1
Hashimoto, T1
Kitaoka, T1
Kyotani, S1
Rosati, A2
Ilvento, L1
Lucenteforte, E1
Pugi, A1
Crescioli, G1
McGreevy, KS1
Virgili, G1
Mugelli, A1
De Masi, S1
Guerrini, R4
Ocek, L1
Tarhan, H1
Uludağ, FI1
Sarıteke, A1
Köse, C1
Colak, A1
Zorlu, F1
Zorlu, Y2
Lee, BI3
No, SK1
Yi, SD1
Lee, HW4
Kim, OJ1
Kim, MK2
Kim, SE3
Kim, YS1
Kim, JM1
Lee, SJ1
Shin, DJ3
Park, SP1
Kim, YI2
Heo, K4
Cho, YW1
Cho, YJ1
Kim, YN1
Xu, S3
Lu, T2
Wang, H5
Liu, S1
Morath, B1
Green, K1
Zaradzki, M1
Heid, J1
Karck, M1
Hoppe-Tichy, T1
Friedrich, L1
Sruk, A1
Bielen, I1
Aguiar, GPS1
Oliveira, JV1
Siebel, AM1
Karlsson Lind, L1
Wide, K4
Egunsola, O2
Choonara, I3
Sammons, HM1
Whitehouse, WP1
Sreedharan, M1
Devadathan, K1
Mohammed Kunju, PA1
Sasidharan, B1
Pillai, JP1
Vasumathy Amma, MA1
Muthubeevi, S1
Jazayeri, D1
Pérez-Esparza, R1
Oñate-Cadena, N1
Ramírez-Bermúdez, J1
Espínola-Nadurille, M1
Čajić, I2
Petelin Gadže, Ž1
Klarica Domjanović, I2
Parveen, B1
Vohora, D1
Güngör, O1
Özkaya, AK1
Temiz, F1
Virta, LJ1
Kälviäinen, R6
Villikka, K1
Keränen, T4
Mercadé Cerdá, JM1
López Gonzalez, FJ1
Serrano Castro, P1
Castro Vilanova, MD1
Campos Blanco, DM1
Querol Pascual, MR1
Rodrigues, C1
Chhun, S1
Chiron, C3
Dulac, O5
Rey, E3
Pons, G2
Jullien, V1
Bolland, MJ1
Avenell, A1
Gamble, G1
Grey, A1
Higashida, K1
Yamagami, H1
Tomari, S1
Fukuma, K1
Okuno, Y1
Abe, S2
Nagatsuka, K1
Toyoda, K1
Ihara, M1
Qiliang, L1
Wenqi, S1
Hong, J1
Liu, RSN1
Wieck, A2
Jones, S1
Ono, H1
Çiçek, NP1
Kamaşak, T2
Serin, M1
Okten, A1
Alver, A1
Cansu, A8
Bonizzoni, E4
Craig, J6
Lindhout, D12
Sabers, A6
Lawthom, C1
Shakir, S2
Nazish, H1
Su, QB1
Tao, YQ1
Qin, JM1
Chen, ZJ3
Zhou, YF1
Zhou, LM4
Wang, XD4
Atweh, S1
Makki, A1
Garne, E1
Addor, MC1
Barisic, I1
Bianchi, F1
Gatt, M1
Lanzoni, M1
Lynch, C1
Mokoroa, O1
Nelen, V1
O'Mahony, MT1
Randrianaivo-Ranjatoelina, H1
Rissmann, A1
Tucker, D1
de Walle, HEK1
Zymak-Zakutnia, N1
Rankin, J1
Kulhas Celik, I1
Tasdemir, HA2
Ince, H1
Celik, H1
Sungur, M1
Lawther, L1
Dolk, H1
Sinclair, M1
Morrow, J7
Petelin-Gadže, Ž1
Kerr, MP2
Macfarlane, A1
Greenhalgh, T1
Zheng, YM1
Zhang, JP1
Tang, S1
Song, DQ1
Alba Palé, L1
Cercós, A1
Samsó, B1
Sugranyes, G1
Durcan, R1
Smyth, S1
Bolster, F1
Janszky, J3
Tényi, D1
Bóné, B2
Contin, M3
Santucci, M5
Riva, R10
Tonon, F1
Mohamed, S1
Ferri, L1
Stipa, C1
Galappatthy, P1
Liyanage, CK1
Lucas, MN1
Jayasekara, DTLM1
Abhayaratna, SA1
Weeraratne, C1
De Abrew, K1
Gunaratne, PS1
Gamage, R1
Wijeyaratne, CN1
Nisha, Y1
Bobby, Z1
Wadwekar, V1
Straus, S1
Dogne, JM1
Bakchine, S1
Haas, M1
Wentzell, N1
Haug, U1
Schink, T1
Engel, S1
Liebentraut, J1
Linder, R1
Onken, M1
Schaefer, C1
Dathe, K1
Zhao, S1
Xu, J1
Zhu, G1
Zhao, C1
Teng, W1
Süße, M1
Hamann, L1
Flöel, A2
Barton, S2
Nadebaum, C2
Anderson, VA1
Reutens, DC3
Wood, AG1
Bai, X2
Xu, C1
Jin, J1
Riker, RR1
Gagnon, D1
May, T6
Fraser, G1
Seder, D1
Hamed, SA5
Rageh, TA1
Mohamad, AO1
Abou Elnour, SM1
El-Haggar, SM1
Mostafa, TM1
Allah, HMS1
Akef, GH1
Ergul Erkec, O1
Algul, S1
Kara, M1
Nashef, L1
Kelly, E1
Sharma, D1
Wilkinson, CJ1
Williams, RSB1
Shaikh, AS1
Cao, L1
Guo, R1
Hynynen, J1
Pokka, T1
Komulainen-Ebrahim, J1
Myllynen, P1
Kärppä, M1
Pylvänen, L1
Sokka, A1
Jyrkilä, A1
Lähdetie, J1
Haataja, L1
Mäkitalo, A1
Ylikotila, P1
Eriksson, K2
Haapala, P1
Ansakorpi, H2
Hinttala, R1
Vieira, P1
Majamaa, K1
Rantala, H1
Uusimaa, J1
Camilleri, L1
Heneghan, C1
Aronson, JK1
Naschitz, JE1
Leibovitz, G1
Izadi Firouzabadi, L1
Geer, K1
Mead, P1
Tsirouda, M1
Dinopoulos, A2
Prasouli, A1
Wang, ZJ1
Chen, HL1
Zhang, LY1
Xu, D2
Jiang, WT1
Pan, Y1
Shen, H1
Sands, TT1
Rahdari, S1
Oldham, MS1
Caminha Nunes, E1
Tilton, N1
Cilio, MR1
Kawakami, Y2
Fujii, S1
Ishikawa, G1
Sekiguchi, A1
Nakai, A1
Takase, M1
Mazzocchetti, P1
D'Alonzo, R1
Siliquini, S3
Rinaldi, VE1
Putignano, D1
Clavenna, A1
Campi, R1
Canevini, MP10
Vignoli, A6
Beghi, E3
Bortolotti, A1
Fortino, I1
Merlino, L1
Bonati, M1
Jacob, L1
Bohlken, J1
Lin, J1
Shen, J1
Ding, S1
Ye, M1
Xia, N1
Chen, H2
Huang, J1
Lv, J1
Brikell, I1
Dalsgaard, S1
Cohen, MJ2
May, R1
Loblein, H1
Conrad, T1
Baker, GA12
Kalayjian, LA4
Kanner, A4
Liporace, JD3
Privitera, M3
Loring, DW6
Ozan, K1
Coskun, Y1
Bora, CK1
Ayten, Y1
Yamada-Takeda, M1
Patel, A1
Fenton, G1
Turner, K3
Assogna, M1
Koristkova, B1
Grundmann, M4
Brozmanova, H4
Kacirova, I4
Lin, C1
Lange, F1
Weßlau, K1
Porath, K1
Hörnschemeyer, J1
Bergner, C1
Krause, BJ1
Mullins, CS1
Linnebacher, M1
Köhling, R1
Kirschstein, T1
Olsen, DB1
Perera, C1
Patterson, S1
Bruxner, G1
Xiao, Y2
Xiong, W2
Lu, L2
Jiang, X1
Rashid, M1
Kashyap, A1
Undela, K1
Cutica, I1
Riva, S1
Zambrelli, E2
Pravettoni, G1
Richards, N1
Reith, D1
Stitely, M1
Smith, A2
Behgal, J1
Rana, R1
Lather, T1
Bala, K2
Vajda, FJ21
Kaushik, S1
Chopra, D1
Laghari, AA1
Ahmed, SI1
Qadeer, N1
Shamim, MS1
Haznedar, P1
Doğan, Ö1
Albayrak, P1
Öz Tunçer, G1
Teber, S3
Deda, G3
Eminoglu, FT1
Jing, X2
Sun, JY1
Xu, ZJ1
Ni, MM1
Wang, T3
Mir, A1
Chaudhary, M1
Alkhaldi, H1
Alhazmi, R1
Albaradie, R1
Housawi, Y1
Ruan, H1
Şahin, S1
Yılmaz, SA1
Arslan, EA1
Kaklıkkaya, N1
Morgan, S1
Raine, J1
Hudson, I1
Baudou, E1
Cances, C1
Dimeglio, C1
Hachon Lecamus, C1
Mousavi-Hasanzadeh, M1
Rezaeian-Varmaziar, H1
Shafaat, O1
Jand, A1
Palizvan, MR1
Guo, C1
Liang, X2
Li, R3
Tian, Q1
Zhang, M3
Chen, D1
Gao, X1
Li, C1
Wen, J1
Tian, X1
Chen, P1
Gao, H1
Qin, X1
Huber-Mollema, Y1
Oort, FJ1
Rodenburg, R1
Sharobeam, A1
Mamun, A1
Kwok, A1
Zandiehvakili, M1
Beran, RG8
Sun, F1
Pasierski, M1
Nurowska, E1
Giuliano, L1
Galimberti, CA7
Ermio, C1
Monti, G1
Papassava, M1
Nakou, I1
Siomou, E1
Cholevas, V1
Challa, A1
Tzoufi, M2
Turaj, W1
Sun, S2
Sheng, Y1
Mroueh, L1
Boumediene, F1
Jost, J1
Ratsimbazafy, V1
Preux, PM1
Salameh, P1
Al-Hajje, A1
Puteikis, K1
Medžiaušaitė, I1
Mameniškienė, R1
Kwong, AK1
Chu, VL1
Rodenburg, RJT1
Smeitink, J1
Fung, CW3
Park, KM1
Patel, M1
Ayus, JC1
Moritz, ML1
Ito, H1
Mori, K1
Kohmoto, T1
Imoto, I1
Gallo Cantafio, ME1
Amodio, N1
Mattace Raso, G1
Lama, A1
Russo, R1
Tallarico, M1
Mishima, N3
Yazawa, R3
Inoue, K5
Itoh, K5
Wilson, KL1
Alexander, JM1
Yoon, H1
Kim, DH2
Awa, HD1
Chelo, D1
Kinkela, MN1
Ndombo, PO1
Kiencke, V1
Andresen-Streichert, H1
Müller, A1
Iwersen-Bergmann, S1
Kato, A1
Kanemura, H2
Sano, F2
Tando, T1
Hosaka, H1
Sugita, K3
Aihara, M2
Grønborg, TK1
Sørensen, MJ1
Schendel, D1
Parner, ET1
Pedersen, LH1
Vestergaard, M2
Pardoe, HR1
Berg, AT2
Jackson, GD1
Saaiq, M1
Iqbal, T1
Siniscalchi, A2
Gallelli, L1
Loizzo, S1
Tiziana, A1
Thome-Souza, S4
Valente, KD5
Kakisaka, Y1
Ito, S3
Ohara, T1
Hino-Fukuyo, N1
Uematsu, M1
Kure, S1
Knights, MJ1
Finlay, E1
Weiner, D1
Nir, V1
Klein-Kremer, A1
Kassem, E1
Munisamy, M1
Behari, M2
Raghavan, S1
Jain, DC1
Ramanujam, B1
Arumugam, K1
Rajakannan, T1
Mallayasamy, SR1
Subbiah, V1
Phabphal, K2
Geater, A2
Rapinesi, C1
Del Casale, A1
Serata, D1
Kotzalidis, GD2
Scatena, P1
Muzi, A1
Lazanio, S2
Savoja, V2
Carbonetti, P1
Fensore, C1
Ferracuti, S1
Angeletti, G1
Tatarelli, R2
Girardi, P1
Nanau, RM1
Neuman, MG1
Mehrpour, M1
Shojaie, M1
Zamani, B1
Gharibzadeh, S1
Abbasi, M1
Amanat, S1
Shahbaz, N1
Hassan, Y1
Dahse, AJ1
Syrbe, S1
Bernhard, MK1
Frontini, R1
Kiess, W1
Merkenschlager, A1
Sonmez, FM3
Zaman, D1
Aksoy, A2
Deger, O2
Aliyazicioglu, R1
Karaguzel, G2
Fazlioglu, K1
Xiaotian, X1
Hengzhong, Z1
Yao, X1
Zhipan, Z1
Daoliang, X1
Yumei, W1
Juneja, M1
Minagawa, K1
Watanabe, T6
Oyanagi, R1
Taşer, N1
Sarıkaya, M1
Gong, Z1
Zou, M1
Xiao, S1
Zhu, W1
Lim, SH3
Chan, E1
Wood, A2
Belcastro, V2
D'Egidio, C3
Sugiyama, M1
Banno, Y1
Nozaki, Y1
Kinoshita, K1
Funauchi, M1
Begum, S1
Sarma, SP1
Altenmüller, DM2
Hebel, JM2
Rassner, MP2
Volz, S2
Freiman, TM2
Feuerstein, TJ2
Zentner, J1
Musleh, C1
Marcuse, L1
Fields, M1
Abe, K1
Hamada, H1
Yamada, T3
Obata-Yasuoka, M1
Minakami, H1
Yoshikawa, H8
Snehunsu, A1
Mukunda, N1
Satish Kumar, MC1
Sadhana, N1
Naduvil Narayanan, S1
Vijay Kapgal, K1
Avinash, H1
Chandrashekar, BR1
Raghavendra Rao, K1
Nayak, BS1
Brzaković, B1
Vučićević, K3
Kovačević, SV3
Miljković, B6
Prostran, M4
Martinović, Ž4
Pokrajac, M4
Walker, MC3
Williams, RS4
Dambach, H1
Hinkerohe, D1
Prochnow, N1
Stienen, MN1
Moinfar, Z1
Haase, CG1
Hufnagel, A1
Faustmann, PM1
Chukwu, J1
Webb, D1
Lee, HS1
Wang, SY1
Salter, DM1
Wang, CC2
Chen, SJ2
Fan, HC2
Suzuki, E5
Takahashi, T3
Koyama, S1
Tsuji, D3
Hayashi, H2
Carvalho, IV1
Carnevale, RC1
Visacri, MB1
Mazzola, PG1
de Fátima Lopes Ambrósio, R1
dos Reis, MC1
de Queiroz, RA1
Moriel, P1
Shallcross, R4
Cheyne, CP3
García-Fiñana, M3
Irwin, B5
Rauchenzauner, M7
Roscia, S1
Prieschl, M1
Wildt, L2
Haberlandt, E5
Baumann, M1
Rostasy, K3
Agostinelli, S5
Pizzolorusso, A1
Luef, G12
Yerdelen, D1
Koc, F1
Avakian, GN2
Oleĭnikova, OM1
Lagutin, IuV1
Khromykh, EA1
Bogomazova, MA1
Delger, AB1
Avakian, GG1
Campbell, E1
Kennedy, F1
Russell, A2
Smithson, WH1
Parsons, L2
Morrison, PJ1
Liggan, B2
Hunt, SJ1
Veiby, G2
Engelsen, BA3
Nakken, KO1
Oakley, CB1
Kulza, M1
Miller, R2
Wozniak, A1
Napierała, M1
Wachowiak, A1
Hassan-Bartz, M1
Krzyścin, M1
Chuchracki, M1
Breborowicz, GH1
Florek, E1
Baek, JH1
Seo, YH1
Kim, GH1
Eun, BL1
Teotonio, R1
Ratnaraj, N3
Duncan, JS3
Patsalos, PN5
Gentile, S1
Merschin, D1
Kerling, F2
Winterholler, M1
Stangl, R1
Bhat, RY1
Kakkar, S1
Prakashini, K1
Chen, XY1
He, L2
Yazal Erdem, A1
Azık, F1
Tavil, B1
Tunç, B1
Uçkan, D1
Singh, E1
Pillai, KK1
Mehndiratta, M1
Smith, V1
Brown, N1
Pegg, EJ1
Zaman, F1
Shi, YJ1
Gong, XW2
Gong, HQ2
Liang, PJ2
Zhang, PM2
Lu, QC2
Kafadar, İ1
Kılıç, BA1
Arapoglu, M1
Yalçın, K1
Dalgıç, N1
Köksal, A1
Dirican, AC1
Altunkaynak, Y1
Yildirim, EA1
Lin, WW1
Wang, CL1
Wang, HY2
Ma, CL1
Huang, PF1
Guo, XZ1
Liu, YW1
Vázquez, M2
Fagiolino, P2
Maldonado, C2
Olmos, I1
Ibarra, M1
Alvariza, S1
Guevara, N2
Magallanes, L1
Olano, I1
Guenther, S1
Bauer, S1
Hagge, M1
Olmes, DG1
Tackenberg, B1
Miyakawa, K1
Dregan, A1
Charlton, J1
Wolfe, CD1
Gulliford, MC1
Markus, HS1
Keenan, N2
Sadlier, LG1
Wiltshire, E2
Borowicz, KK5
Zarczuk, R1
Latalski, M1
Borowicz, KM1
Oguni, H1
Inoue, T2
Matsumoto, R1
Ikeda, A1
Baxter, P1
Inoue, M1
Yamamoto, A1
Kaneko, Y1
Noda, A1
Naito, H1
Havali, C1
Gücüyener, K4
Buyan, N1
Yılmaz, Ü1
Gürkaş, E1
Gülbahar, Ö2
Demir, E2
Serdaroğlu, A10
Fang, ZY3
Wang, HS2
Li, JL2
Zhou, JQ3
Huang, HB1
Bonnett, LJ2
Donegan, S1
Fang, Z2
Zhou, J3
Eglit, T1
Kõks, S3
Lember, M1
Petty, SJ2
Kantor, S2
Lawrence, KM1
Berkovic, SF4
Collins, M2
Hill, KD1
Makovey, J1
Sambrook, PN1
Wark, JD2
Goldberg-Stern, H3
Yaacobi, E1
Phillip, M2
de Vries, L3
Huo, T1
Lu, X2
Qu, L1
Cai, S1
Öz, O3
Korkmaz, M1
Alay, S1
Tasdemir, S1
Cetiz, A1
Demirkaya, S1
Tseng, YL1
Huang, CR3
Lin, CH3
Lu, YT2
Lu, CH2
Chen, NC2
Chang, CC2
Chang, WN2
Chuang, YC3
Kim, HJ1
Kim, TE1
Joo, EY1
Seo, DW1
Hong, SB1
Lee, WB1
Kumar, PK1
Ng, YL1
Wong, PS1
Wei, D1
Yang, F3
Wu, C1
Wu, SX1
Shazadi, K1
Petrovski, S1
Roten, A3
Miller, H1
Huggins, RM1
Brodie, MJ19
Pirmohamed, M2
Star, K1
Edwards, IR1
Hanrath, MA1
Swart, EL1
Adab, N4
Greenhalgh, J1
Sanniti, A1
McKay, AJ1
Ogusu, N3
Saruwatari, J5
Nakashima, H2
Noai, M3
Nishimura, M2
Deguchi, M2
Oniki, K4
Kaneko, S7
Ishitsu, T7
Nakagaswa, K1
Jovanović, M1
Golubović, B1
Ding, J1
Miao, L1
Prakash, S2
Harbo, T2
Sadleir, L1
Dwivedi, R1
Singh, M1
Joshi, R1
Tiwari, P1
Uğur, C1
Saday Duman, N1
Bektaş, O1
Kağan Gürkan, C1
Trivisano, M1
Zhu, D1
Su, Z1
Ye, S1
Zhuge, G1
Wu, Z1
Hirsch, LJ2
Moeller, J1
Javed, A1
Kato, K1
Legge, A1
Buchsbaum, R2
Detyniecki, K1
Sirisamut, T1
Chinvarun, Y1
Tantisira, MH1
Briggs, M2
Gummery, A1
Kneen, R1
Mawer, G5
Klein, P1
Fukuda, M2
Kawabe, M1
Takehara, M1
Iwano, S1
Kuwabara, K1
Kikuchi, C1
Wakamoto, H1
Morimoto, T1
Suzuki, Y4
Ishii, E1
Sargar, KM1
Herman, TE1
Siegel, MJ1
Miranda Herrero, MC1
Alcaraz Romero, AJ1
Escudero Vilaplana, V1
Fernández Lafever, SN1
Fernández-Llamazares, CM1
Barredo Valderrama, E1
Vázquez López, M1
de Castro, P1
Mishra, A1
Jellett, AP1
Jenks, K1
Lucas, M1
Scott, RC1
Ide, M1
Kato, T2
Nakata, M1
Saito, K1
Yoshida, T1
Awaya, T1
Heike, T1
Luo, Z1
Fang, Y1
Zhang, L1
Moussa, EM1
Tohamy, AM1
Mohamed, KO1
Mohamad, ME1
Sherif, TM1
Abdellah, MM1
Hou, X1
Xie, W2
Xin, S1
Zighetti, ML1
Fontana, G2
Lussana, F1
Chiesa, V1
Cattaneo, M1
Itzhaki, T1
Landau, Z2
Yamak, WR1
Hmaimess, G1
Makke, Y1
Sabbagh, S1
Arabi, M1
Pintaudi, M1
Calevo, MG1
Baglietto, MG1
Hayek, Y1
Traverso, M1
Giacomini, T1
Giordano, L1
Renieri, A1
Russo, S1
Canevini, M1
Veneselli, E1
Martínez-Lazcano, MT1
Esplá-González, S1
Herraiz-Robles, P1
Hernández-Pérez, P1
Chillerón-Cuenca, R1
Grzyb, E1
Kwiecińska, P1
Gregoraszczuk, EL1
Ziyatdinova, S1
Viswanathan, J1
Hiltunen, M1
Tanila, H1
Pitkänen, A1
Marson, A1
Boon, P1
Covanis, A4
Gaily, E4
Trinka, E10
Wilimowska, J1
Kłys, M1
Jawień, W1
Liang, M2
Dong, Y2
Yun, W2
Qiu, F6
Szever, Z2
Temesvári, M2
Háfra, E2
Garami, M2
Tapodi, A2
Dereci, S1
Koca, T1
Akçam, M1
Türkyilmaz, K1
Gavzan, H1
Sayyah, M1
Sardari, S1
Babapour, V1
Anderson, M1
Cherrill, J1
Millward, C1
Fakis, A1
Overwater, IE1
Bindels-de Heus, K1
Rietman, AB1
Ten Hoopen, LW1
Vergouwe, Y1
Moll, HA1
de Wit, MC1
Van McCrary, S1
Hanley, P1
Cunningham, RJ1
Lou, L1
Vog, B1
Raina, R1
Sun, YX1
Zhuo, WY1
Lin, H1
Peng, ZK1
Wang, HM1
Huang, HW1
Luo, YH1
Tang, FQ1
Harit, D1
Aggarwal, A2
Kalra, S1
Chhillar, N1
Işık, M1
Demir, Y1
Kırıcı, M1
Demir, R1
Beydemir, Ş1
Beltrame, A1
Venturini, S1
Crichiutti, G1
Meroni, V1
Buonfrate, D1
Bassetti, M1
Moses, L1
Katz, N1
Weizman, A1
Azumagawa, K1
Mino, M1
Ishida, N1
Shichiri, M1
Shigeri, Y1
Yoshida, Y1
Tamai, H1
Herrmann, LS1
Watanabe, S1
Yamamori, S1
Otsuka, S1
Kataoka, M1
Takahashi, M3
Soraoka, H1
Kajiwara, A1
Tanamachi, Y1
Nakagawa, K7
Thompson, K1
Pohlmann-Eden, B2
Campbell, LA1
Abel, H1
Khachidze, I1
Gugushvili, M1
Makashvili, M1
Maloletnev, V1
Ma, Y1
Carmona-Vazquez, CR1
Ruiz-Garcia, M1
Pena-Landin, DM1
Diaz-Garcia, L1
Greenawalt, SR1
Linder, C1
Andersson, M1
Beck, O1
Pohanka, A1
Homberg, V1
Cho, YS1
Ah, YM1
Jung, AH1
Lee, JY1
Berendsen, S1
Varkila, M1
Kroonen, J1
Seute, T1
Snijders, TJ1
Kauw, F1
Spliet, WG1
Willems, M1
Poulet, C1
Broekman, ML1
Bours, V1
Robe, PA1
Yin, T2
Liu, DQ1
Sheng, YH1
Zhou, BT2
Sharma, TK1
Vardey, SK1
Sitaraman, S1
Shimomasuda, M1
Ono, T1
Matsuda, K1
Hirai, K1
Sánchez-Yáñez, E1
Estaún-Martínez, C1
Ojeda Burgos, G1
Weissinger, F1
Fidzinski, P1
Losch, F1
Meng, H1
Villegas-Martínez, I1
de-Miguel-Elízaga, I1
Carrasco-Torres, R1
Marras, C1
Canteras-Jordana, M1
Yedra-Guzmán, MJ1
Martínez-Villanueva, M1
Tortosa-Conesa, D1
Martín-Fernández, J1
Lavi-Blau, T1
Ekstein, D1
Neufeld, MY1
Eyal, S1
Happold, C1
Gorlia, T1
Chinot, O1
Gilbert, MR1
Nabors, LB1
Wick, W1
Pugh, SL1
Hegi, M1
Cloughesy, T1
Roth, P1
Reardon, DA1
Perry, JR1
Mehta, MP1
Stupp, R1
Weller, M1
Sakellarides, M1
Christie, J1
Todaro, M1
Gorelik, A1
Seibel, MJ1
Yerra, R1
Vreeburg, SA1
Leijten, FS1
Sommer, IE1
Sato, S3
Murphy, S1
Bennett, K1
Doherty, CP1
Bae, EK1
Lee, J1
Shin, JW1
Moon, J1
Lee, KJ1
Shin, YW1
Kim, TJ1
Shin, D1
Jang, IJ2
Lee, SK1
Töllner, K1
Twele, F1
Löscher, W15
Solignac, I1
Solak, B1
Oztas Kara, R1
Erdem, T1
Queijo, C1
González, R1
Lin, K1
Guaranha, M1
Wolf, P3
Koemtzidou, E1
Kossiva, L1
Katsarou, E5
Soldatou, A1
Casassus, B1
Takeuchi, T1
Natsume, J1
Kidokoro, H1
Ishihara, N1
Yamamoto, H2
Ito, Y1
Kurahashi, N1
Tsuji, T1
Suzuki, M1
Itomi, K1
Yamada, K1
Maruyama, K1
Negoro, T2
Watanabe, K4
Kojima, S1
Vanya, M1
Devosa, I1
Szok, D1
Bártfai, G1
Johannsen, J1
Nickel, M1
Schulz, A1
Denecke, J1
Al-Mendalawi, MD2
Talat, M1
Ilić, V1
Bogićević, D1
Ješić, M1
Kovačević, M1
Spilioti, M1
Gogou, M1
Katsanika, I1
Papadopoulou-Alataki, E1
Grafakou, O1
Gkampeta, A1
Evangeliou, A1
Baldoni, AO1
Freitas-Lima, P1
de Santi Ferreira, FI1
Martinez, EZ1
Queiroz, RH1
Sakamoto, AC1
Alexandre, V1
Pereira, LR1
McKenzie, ED1
Nirola, DK1
Deki, S1
Tshering, L1
Patenaude, B1
Clark, SJ1
Cash, SS1
Thibert, R1
Zepeda, R1
Leung, EC1
Lam, AD1
Lim, AS1
Mantia, J1
Cohen, J1
Cole, AJ1
Mateen, FJ1
Balon, R1
Riba, M1
Lin, CM2
Chao, TY1
Chu, DM1
Lai, CC1
Albaghdadi, O1
Alhalabi, MS1
Alourfi, Z1
Youssef, LA1
Singh, T3
Herzog, AG5
Mandle, HB1
Cahill, KE1
Fowler, KM2
Hauser, WA3
Kakkar, AK1
Albsoul-Younes, A1
Gharaibeh, L1
Murtaja, AA1
Masri, A1
Alabbadi, I1
Al-Qudah, AA1
Wen, ZP1
Fan, SS1
Du, C1
Peng, ZF1
Xie, YY1
Tang, J1
Xiao, J1
Van Matre, ET1
Cook, AM1
Pontes, JC1
Lima, TZ1
Queiroz, CM1
Cinini, SM1
Blanco, MM1
Mello, LE1
Mutlu-Albayrak, H1
Bulut, C1
Çaksen, H4
Fu, Y1
Zhan, Q1
Huang, S1
Long, H1
Zhou, P1
Liu, C2
Long, L1
Xiao, B1
Noack-Rink, M1
Ramirez, F1
Tofighy, A1
Werhahn, KJ1
Wild, I1
Zhang, Q2
Hu, Z1
Dante, M1
Li, K2
Lu, G1
Robertson, NP1
Calderbank, R1
Rooney, C1
Trayner, P1
Morrow, JI1
Lai, EC2
Hsieh, CY2
Su, CC1
Yang, YK1
Huang, CW1
Lin, SJ2
Setoguchi, S1
Płonka-Półtorak, E2
Zagrodzki, P2
Kryczyk-Kozioł, J1
Westermarck, T3
Kaipainen, P3
Kaski, M3
Atroshi, F3
Wieshmann, UC1
Habets, JGV1
Leentjens, AFG1
Schijns, OEMG1
Jiao, Y1
Kmietowicz, Z1
Deng, XL1
Yin, F2
Zhang, CL2
Ma, YP1
He, F1
Wu, LW1
Peng, J2
Stockis, A3
Sargentini-Maier, ML1
Masson, M2
Huberfeld, G1
Richa, S1
Henry, C2
Gaillard, R1
Wu, M2
Hao, N1
Yan, B1
Chi, X1
Su, Y1
Tian, F1
Ren, G1
Jiang, M1
Chun, B1
Ye, H1
Gao, D1
Yan, H1
He, RH1
Tang, YJ1
He, YJ1
Tan, D1
Mao, XY1
Yin, JY1
Liu, ZQ1
Zhou, HH1
Corbelli, I1
Eusebi, P1
Bedetti, C1
Caproni, S1
Cupini, LM2
Sarchielli, P2
Savini, MN1
Nowbut, MS1
Peron, A1
La Briola, F1
Kasradze, S3
Gogatishvili, N1
Lomidze, G1
Ediberidze, T1
Lazariashvili, M1
Khomeriki, K1
Mamukadze, S1
Metreveli, M1
Gagoshidze, T1
Tatishvili, N1
Hartzema, A1
Delaney, JA1
Brumback, B1
Egerman, R1
Roth, J1
Segal, R1
Würtz, AM1
Rytter, D1
Vestergaard, CH1
Bech, BH1
Nazmy, EA1
El-Khouly, OA1
Atef, H1
Said, E1
Serragui, S1
Zalagh, F1
Tanani, DS1
Ouammi, L1
Moussa, LA1
Badrane, N1
Bencheikh, RS1
Liang, L1
Ma, X1
Su, M1
Sedky, AA1
El Serafy, OMH1
Hassan, OA1
Abdel-Kawy, HS1
Hasanin, AH1
Raafat, MH1
Yun, Y1
Xie, X1
You, C1
Miao, H1
Zhang, F1
Gao, S1
Liao, W1
Wu, Y1
Lang, S1
Zhao, H2
Hsiao, SC1
Tsai, WC1
Chen, SD3
Schoemaker, R1
Wade, JR1
Gubensek, J1
Buturovic-Ponikvar, J1
Ponikvar, R1
Cebular, B1
Liao, HM1
Tang, JW1
Peng, QL1
Bromfield, EB2
Dworetzky, BA2
Wyszynski, DF3
Smith, CR2
Baldwin, EJ1
Holmes, LB4
Joffe, H2
Hayes, FJ2
Fida, NM1
Hamed, EA1
van de Vrie-Hoekstra, NW1
de Vries, TW1
van den Berg, PB1
Brouwer, OF4
de Jong-van den Berg, LT2
Apeland, T2
Frøyland, ES1
Kristensen, O2
Strandjord, RE2
Mansoor, MA2
Okada, A1
Onishi, Y1
Shimshoni, JA2
Kaufmann, D2
Fujiwara, M1
Song, J1
Parker, L1
Hormozi, L1
Tanouye, MA1
Go, T1
Zsurka, G1
Baron, M1
Stewart, JD1
Kornblum, C1
Bös, M1
Sassen, R1
Taylor, RW2
Elger, CE4
Chinnery, PF2
Espinosa, PS1
Salazar, JC1
Mendiondo, MS1
Robertson, WC1
Baumann, RJ3
Desai, J1
Morrell, MJ7
Sluss, PM1
Adams, JM1
Bhatt, M1
Warnock, CR1
Isojärvi, J6
Kluger, BM1
Gilad, R1
Izkovitz, N1
Dabby, R1
Rapoport, A1
Sadeh, M1
Weller, B1
Lampl, Y1
Grisotto, KP1
Bruck, I2
Antoniuk, SA2
Santos, LH1
Arslan, M1
Vurucu, S2
Balamtekin, N1
Unay, B2
Akin, R5
Kurt, I1
Ozcan, O3
Aydin, S1
Dag, E1
Yilmaz, Y1
Paksu, MS1
Kanemoto, K1
Tadokoro, Y1
Oshima, T1
Dewan, P1
Faridi, MM1
Jones, BJ1
Twomey, PJ1
Laus, M1
Scardapane, A1
Franzoni, E4
Chiarelli, F29
Tomoum, HY3
Awadallah, MM1
Fouad, DA1
Ali, AH1
Harden, CL4
Sethi, NK1
Meo, R4
Mehndiratta, MM1
Mehndiratta, P1
Phul, P1
Garg, S1
Mayor-Dubois, C1
Maeder-Ingvar, M1
Deonna, T1
Roulet-Perez, E1
Grosso, S3
Mostardini, R2
Piccini, B2
Balestri, P3
Correa, T1
Rodríguez, I2
Romano, S1
Schreiner, A1
Stollhoff, K1
Ossig, W1
Unkelbach, S1
Lüer, W1
Bogdanow, M1
Schauble, B1
Dudley, RW1
Penney, SJ1
Buckley, DJ1
Unal, O1
Ertem, M1
Akar, N1
Anil, M1
Helvaci, M1
Ozbal, E1
Kalenderer, O1
Anil, AB1
Dilek, M1
Larsen, K1
Blichfeldt, S1
Sahlholdt, L1
Rasmussen, JO1
Pierre-Louis, SJ1
Brannegan, RT1
Evans, AT1
Di Marco, G1
la Torre, R2
Pelliccia, P2
Trotta, D8
Mohn, A2
Chwalczuk, K1
Rubaj, A1
Swiader, M1
Krishnamoorthy, G1
Karande, S1
Ahire, N1
Mathew, L1
Kulkarni, M1
San Antonio Arce, V1
Joyanes Abancens, B1
Jovanovic, D1
Milovanovic, JR3
Gorkemli, H1
Genc, BO1
Dogan, EA1
Genc, E1
Ozdemir, S1
Sharpe, C1
Wolfson, T1
Trauner, DA1
Yiş, U3
Seçkin, E1
Kurul, SH1
Kuralay, F1
Dirik, E4
Franciotta, D2
Blum, AS2
Farina, EL2
Maestri, XE1
Newman, J1
Garcia, E1
Krishnamurthy, KB1
Hoch, DB1
Replansky, S1
Smithson, SD1
Shorvon, SD3
DeWolfe, JL1
Knowlton, RC1
Beasley, MT1
Cofield, S1
Faught, E5
Limdi, NA3
Ackers, R1
Besag, FM5
Wade, A1
Murray, ML1
Wong, IC2
Sadzot, B1
Moonen, G1
Schreur, L1
Middeljans-Tijssen, CW1
Hengstman, GJ1
Olde Rikkert, MG1
Samaei, A1
Nobahar, M1
Vafaei, AA1
Luszczki, JJ3
Krzyzanowski, M1
Swiader, MJ1
Browning, N2
Combs-Cantrell, DT2
Cohen, M2
Gronseth, GS2
French, JA3
Wiebe, S2
Thurman, D2
Koppel, BS2
Kaplan, PW3
Robinson, JN2
Hopp, J2
Ting, TY2
Gidal, B3
Hovinga, CA3
Wilner, AN2
Vazquez, B2
Holmes, L2
Krumholz, A2
Finnell, R2
Hirtz, D2
Le Guen, C2
van Raay, L2
Morris, MJ2
Reed, RC10
Dedeurwaerdere, S2
Yip, FP1
Hui, AC1
Leung, H1
Ng, PW1
Hui, KF1
Chan, IH1
Chan, MH1
Lam, CW3
Abdella, MM1
Thibert, RL1
Conant, KD1
Braun, EK1
Bruno, P1
Said, RR1
Nespeca, MP1
Thiele, EA2
Schmitt, B1
Martin, F1
Critelli, H1
Molinari, L1
Jenni, OG1
Köse, G1
Arhan, E4
Unal, B1
Ozaydin, E1
Guven, A1
Sayli, TR1
Bozhinov, P1
Bozhinova, C1
Markova, C1
Ma, MS2
Ding, YX2
Ying, W1
Ding, CH2
Zou, LP2
Mariani, R1
Spalice, A3
Rocchi, V1
Iannetti, P3
Feily, A1
Namazi, MR1
Dinis-Oliveira, RJ1
Magalhães, T1
Carvalho, F1
Santos, A1
Aiba, T3
Ishikawa, N1
Sato, T4
Kawasaki, H3
Kurosaki, Y3
Ohtsuka, Y4
Sendo, T3
Darra, F1
La Selva, L1
Fiorini, E1
Piazzini, A1
Lazzarotto, F1
Zucca, C2
Dalla Bernardina, B1
Wojda, E1
Wlaz, A1
Seidahmed, MZ1
Guevara-Campos, J1
González-Guevara, L1
Vacaro-Bolívar, I1
Rojas, JM1
Fraunberger, B2
Yang, T1
Pauli, E1
Stefan, H5
Varoglu, AO2
Mowinckel, P2
Gjerstad, L9
Liu, YH1
Huang, YG1
van Vliet, EA1
Edelbroek, PM2
Gorter, JA1
Manco, R1
Peker, E1
Oktar, S1
Ari, M1
Kozan, R1
Doğan, M1
Cağan, E1
Söğüt, S1
Griesmacher, A1
Tatarczyk, T2
Strasak, A1
Zimmerhackl, LB3
Falkensammer, G1
Högler, W1
Gökçil, Z2
Bek, S1
Cakir, E1
Odabaşi, Z2
Terbach, N1
Jiang, D1
Li, L2
Müller, M1
Prodam, F1
Bellone, S1
Casara, G1
De Rienzo, F1
Grassino, EC1
Bonsignori, I1
Demarchi, I1
Rapa, A1
Radetti, G1
Bona, G1
Grabnar, I1
Trivedi, A1
Halliday, R1
Waters, K1
Levison, J1
Dutta, S12
Liu, W1
McVearry, KM1
Gaillard, WD3
VanMeter, J1
Abaci, A1
Saygi, M1
Demir, K1
Bober, E2
Ratanajamit, C1
Kaewpibal, P1
Setthawacharavanich, S1
Faroongsarng, D1
Beers, E1
van Puijenbroek, EP1
Bartelink, IH1
van der Linden, CM1
Jansen, PA1
Song, D1
Chiu, W1
Chang, P2
Chandler, KE1
Aldemir, E2
Akdeniz, F3
Hollingworth, S2
Bitsche, G1
Svalheim, S2
Tauboll, E1
Mula, M1
Dorszewska, J1
Winczewska-Wiktor, A1
Sniezawska, A1
Kaczmarek, I1
Steinborn, B5
Zeng, K2
Xi, Z2
Yan, Y1
Boylu, E1
Domaç, FM1
Misirli, H1
Senol, MG1
Saraçoğlu, M1
Sgobio, C2
Ghiglieri, V2
Bagetta, V2
Barone, I1
Di Filippo, M1
Gardoni, F1
Gundelfinger, ED2
Di Luca, M1
Picconi, B2
Kim, JE1
Choi, HC1
Song, HK2
Jo, SM1
Kim, DS1
Choi, SY1
Kang, TC1
Tan, L3
Yu, JT1
Sun, YP2
Ou, JR1
Song, JH2
Saneto, RP1
Lee, IC1
Koenig, MK1
Bao, X1
Weng, SW1
Naviaux, RK1
Wong, LJ1
Bøhmer, T1
Bøen, A1
Høymork, SC1
Farkas, Z1
Gulyás, S1
Molnár, R1
Szirmai, I1
Kamondi, A1
Mazurkiewicz-Bełdzińska, M1
Szmuda, M1
Matheisel, A1
Patassini, S1
Fejtova, A1
Giampà, C1
Marinucci, S1
Heyden, A1
Fusco, FR1
Hrebackova, J1
Hrabeta, J1
Eckschlager, T1
El-Khayat, HA2
Aly, GS1
Mamdouh, RM1
Al-Badani, AK1
Mohamed, EI1
Endo, A1
Fujita, Y1
Fuchigami, T1
Takahashi, S1
Mugishima, H1
Santos, BL1
Fernandes, RM2
Neves, FF1
Arzy, S1
Allali, G1
Brunet, D1
Michel, CM1
Seeck, M1
Grover, S1
Gourie-Devi, M1
Baghel, R1
Kaur, H1
Gupta, M3
Talwar, P1
Miliauskas, S1
Liesiene, V1
Zemaitis, M1
Sakalauskas, R1
Visudtibhan, A1
Bhudhisawadi, K1
Vaewpanich, J1
Chulavatnatol, S1
Kaojareon, S1
Yagi, M1
Nakamura, T1
Okizuka, Y1
Oyazato, Y1
Tsuneishi, S1
Sakaeda, T1
Matsuo, M1
Okumura, K1
Okamura, N1
Gaspari, CN1
Guerreiro, CA2
Podymova, SD1
Sadovnikova, IV1
Elibrahimi, I1
Draiss, G1
Safini, F1
Amine, M1
Bouskraoui, M1
Bujoreanu, IS1
Ibeziako, P1
DeMaso, DR1
Lambrinoudaki, I1
Kaparos, G1
Armeni, E1
Alexandrou, A1
Damaskos, C1
Logothetis, E1
Creatsa, M1
Antoniou, A1
Kouskouni, E1
Triantafyllou, N1
Leonard, H1
Downs, J1
Jian, L1
Bebbington, A1
Jacoby, P1
Nagarajan, L1
Ravine, D1
Woodhead, H1
Yildirim, A1
Aygul, R1
Gundogdu, OL1
Sahin, YN1
Singh, RP1
Dhariwal, D1
Bhujel, N1
Shaikh, Z1
Nishikawa, H1
Solanki, G1
Dover, MS1
Sendrowski, K1
Sobaniec, W3
Boćkowski, L2
Kułak, W3
Smigielska-Kuzia, J2
Wei, C1
Gao, L1
Liu, YP1
Huang, NN1
Xu, SJ1
Ma, DJ1
Wang, KL1
Shi, RF1
Tang, HX1
Hill, M1
Zárubová, J1
Marusič, P1
Vrbíková, J1
Velíková, M1
Kancheva, R1
Kancheva, L1
Kubátová, J1
Dušková, M1
Zamrazilová, L1
Kazihnitková, H1
Simůnková, K1
Stárka, L1
Lampón, N3
Tutor, JC4
Srinivasan, S1
Lok, AW1
Love, J1
Kelly, J1
Purdy, L1
McEwan, L1
Sin, X1
Viteri, C1
Cobaleda, S1
Lahuerta, J1
Barriga, J1
Morales, MD1
Meng, LL1
Yuen, AW2
Bell, GS2
Peacock, JL1
Koepp, MM1
Hen, N1
Kurt, AN1
Aslanyavrusu, M1
Chateauvieux, S1
Morceau, F1
Dicato, M1
Diederich, M1
Zhao, Y1
Yasuhara, A4
Dahlin, MG2
Ohman, I3
Gulati, S2
Kabra, M2
Kalra, V1
Vasisht, S1
Longini, M1
Rodriguez, A1
Proietti, F1
Buonocore, G1
Yu, PM1
Wu, XY1
Li, T1
Yue, L1
Fucic, A1
Stojković, R1
Miškov, S1
Zeljezic, D1
Markovic, D1
Gjergja, R1
Katic, J1
Jazbec, AM1
Bakulic, TI1
Demarin, V1
De Rinaldis, M1
Gennaro, L1
Losito, L1
Trabacca, A1
Jankovic, S2
Luisi, S1
Matera, M1
Barlocco, EG1
Casarosa, E1
Petraglia, F1
Bondareva, IB2
Jelliffe, RW2
Andreeva, OV1
Bondareva, KI1
Navas-Sánchez, P1
Martínez-Antón, J1
Bauzano-Poley, E1
D'Aniello, A1
Arcieri, S1
Della Corte, R1
Ammendola, E1
Pascotto, A3
Anderson, V1
Reutens, D1
Hogan, RE1
Ozturk, B1
Ozturk, HS1
Ozcelik, A1
Kurt, N1
Kutsal, E1
Sevinc, N1
Ozdemir, O1
Yakut, A1
Dinleyici, EC1
Aydogdu, SD1
Yarar, C1
Colak, O1
Mindikoglu, AL1
King, D1
Magder, LS1
Ozolek, JA1
Mazariegos, GV1
Shneider, BL1
Nakajima, Y1
Ito, T1
Maeda, Y2
Ichiki, S1
Kobayashi, S1
Ando, N1
Hussein, MH1
Kurono, Y1
Sugiyama, N2
Togari, H1
Matsunaga, H1
Martin, AC1
Berry, DJ3
Besag, FP1
Chaudrey, KH1
Naser, TB1
Steinberg, A1
Avashia, KD1
Nouri-Kolouri, M1
Asadi, S1
Irshad Khan, SI1
Ihsan, M1
Therisa, KK1
Desai, PV1
Olesen, JB1
Hansen, PR1
Abildstrøm, SZ1
Andersson, C1
Weeke, P1
Schmiegelow, M1
Erdal, J1
Torp-Pedersen, C1
Gislason, GH1
Çoban, D1
Kurtoğlu, S1
Akın, MA1
Akçakuş, M1
Güneş, T1
Haerian, BS4
Lim, KS3
Mohamed, EH3
Tan, CT3
Wong, CP3
Mohamed, Z4
Chłopicka, J1
Bartoń, H1
Gamez, G1
Disko, A1
Azov, V1
Chingin, K1
Krämer, G4
Zenobi, R1
Roslan, H1
Cummings, C1
Stewart, M1
Stevenson, M1
Nelson, J1
Ramaratnam, S2
Ounjaijean, S1
Partinen, M1
Plonka-Poltorak, E1
Fucharoen, S1
Srichairatanakool, S1
Mathieu, O1
Picot, MC1
Gelisse, P4
Breton, H1
Demoly, P1
Hillaire-Buys, D1
Bos, MJ1
de Weerd, AW1
Hagebeuk, EE1
Talamo, A1
Vento, A1
Di Cosimo, D1
Manfredi, G1
Girardi, N1
Pronicka, E1
Weglewska-Jurkiewicz, A1
Pronicki, M1
Sykut-Cegielska, J1
Kowalski, P1
Pajdowska, M1
Jankowska, I1
Kotulska, K1
Kalicinski, P1
Jakobkiewicz-Banecka, J1
Wegrzyn, G1
Topf, HG1
Lischetzki, G1
Trollmann, R1
Rascher, W2
Rauh, M1
Chen, WB1
Gao, R1
Su, YY1
Zhao, JW1
Zhang, YZ1
Ren, Y1
Fan, CQ1
Gulcebi, MI1
Ozkaynakcı, A1
Goren, MZ1
Aker, RG1
Onat, FY1
Yoshino, A1
Itoh, H2
Abe, T5
Nishimura, F1
Sato, Y3
Takeyama, M5
Mehla, J1
Pahuja, M1
Bittner, S1
Höhn, K1
Göbel, K1
Kleinschnitz, C1
Wiendl, H1
Meuth, SG1
Camurdan, O4
Hırfanoğlu, T3
Cinaz, P3
Bai, HX1
Ma, MH1
Orabi, AI1
Park, A1
Latif, SU1
Bhandari, V1
Husain, SZ1
Mania, M2
Okujava, N2
Erickson, SC1
Le, L1
Ramsey, SD1
Solow, BK1
Zakharyan, A1
Stockl, KM1
Harada, AS1
Curtis, B1
Rhee, Y1
Lee, SA2
Kim, WJ1
Song, K1
Gomez-Ibañez, A1
Urrestarazu-Bolumburu, E1
Viteri-Torres, C1
Mink, S1
Muroi, C1
Seule, M1
Bjeljac, M1
Keller, E1
Nanni, G1
Alleva, ET1
Aloisi, P1
Bachmann, T1
Bertheussen, KH1
Machado, VH1
Bastos, FA1
Rotert, R1
Mao, ZN1
Gao, ZG1
Zhang, GW1
Wang, SB1
Ezz, HS1
Khadrawy, YA2
Noor, NA2
Kulaga, S1
Sheehy, O1
Zargarzadeh, AH1
Moussally, K1
Bérard, A1
Hung, CC1
Ho, JL1
Chang, WL1
Tai, JJ1
Hsieh, TJ1
Hsieh, YW1
Liou, HH2
Hu, X2
Dong, W1
Fang, Q1
Kim, KB1
Seo, KA1
Bae, SK1
Shin, JG1
Davison, AS1
Milan, AM1
Roberts, NB1
Orabi, B1
Deranieh, RM1
Dham, M1
Hoeller, O1
Greenberg, ML1
Horgan, D1
Cai, YH1
Zhang, LL1
Zeng, LN1
Li, YP1
Kotov, AS1
Rudakova, IG1
Fisahn, A1
Lavebratt, C1
Canlon, B1
Prins, MC1
van Meijel, JJ1
Werler, MM1
Ahrens, KA1
Bosco, JL1
Mitchell, AA1
Anderka, MT1
Gilboa, SM1
Dupuis, M1
van Rijckevorsel, K2
Evrard, F1
Dubuisson, N1
Dupuis, F1
Van Robays, P1
Tesfaye, H1
Klapková, E1
Tesfayeová, A1
Komárek, V1
Shu, WY1
Shekh-Ahmad, T1
Yavin, E1
Baraka, AM1
Hassab El Nabi, W1
El Ghotni, S1
Singh, G2
Driever, PH3
Chuang, HY1
Lin, TK1
Tan, TY1
Chan, SH1
Xiang, L1
Ding, JQ1
Huang, XS1
Sahu, JK1
Arya, R1
Gupta, N1
Yoshimori, Y1
Yoshida, S3
Sasidaran, K1
Singhi, S1
Singhi, P2
Turan, AB1
Seferoglu, M1
Taskapilioglu, O1
Timmings, PL1
Kasteleijn-Nolst Trenité, DG2
Hosver, I1
Javashvili, L1
Williams, JH1
Jayaraman, B1
Swoboda, KJ1
Barrett, JS1
Poolos, NP1
Warner, LN1
Humphreys, SZ1
Williams, S1
Kobayashi, K3
Endoh, F1
Yoshinaga, H2
Zarnowska, I1
Zarnowski, T1
Gasior, M2
Biberoglu, G2
Tumer, L1
Hirfanoglu, TL2
Ezgu, FS1
Hasanoglu, A2
Kukla, P1
Jastrzębski, M1
Czamara, M1
Bryniarski, L1
Przyprawa, A1
Bałajewicz, J1
Chabwine, JN1
Rossetti, AR1
Hirt, L1
Kuntzer, T1
Schluep, M1
Michel, P1
Démonet, JF1
du Pasquier, RA1
Vingerhoets, FG1
Deng, X1
Mei, R1
Zhang, YJ1
Wang, XC1
Yu, YH1
Jin, PJ1
Bochyńska, A1
Lipczyńska-Łojkowska, W1
Gugała-Iwaniuk, M1
Lechowicz, W1
Restel, M1
Graban, A1
Lipska, B1
Ryglewicz, D1
Mawhinney, E1
Campbell, J1
Smithson, W1
Robertson, I1
Morrison, P1
Hunt, S1
Talati, R1
Scholle, JM1
Phung, OP1
Baker, EL1
Baker, WL1
Ashaye, A1
Kluger, J1
Coleman, CI1
White, CM1
Yildiz, M1
Chu, XM1
Zhang, LF1
Wang, GJ1
Zhang, SN1
Zhou, JH1
Hao, HP1
Limapichat, K1
Sathirapanya, P1
Setthawatcharawanich, S1
Jentink, J1
Boersma, C1
Postma, MJ1
Rosemergy, I1
Bergin, P1
Jones, P1
Walker, E1
Dodel, R1
Balzer-Geldsetzer, M1
Reese, JP1
Schöffski, O1
Oertel, WH2
Aboul Ezz, HS1
Faraag, AR1
Brzaković, BB1
Vezmar Kovačević, SD1
Vučićević, KM1
Miljković, BR1
Martinović, ZJ1
Pokrajac, MV1
Prostran, MŠ1
Tremolizzo, L2
Difrancesco, JC1
Rodriguez-Menendez, V2
Riva, C1
Conti, E1
Galimberti, G1
Ruffmann, C1
Ferrarese, C1
Sirmagul, B1
Atli, O1
Ilgin, S1
Chung, HR1
Lim, BC1
Chae, JH1
Hwang, YS1
Yesilkaya, E1
Karaoglu, A1
Bideci, A4
Tokgoz, H2
Aydin, K3
Oran, B2
Kiyici, A1
Rosenzweig, I1
Vukadinovic, Z1
Turner, AJ1
Catani, M1
Tan, WW1
Chan, DW1
Fujisaki, K1
de Laat, SA1
Hillegers, MH1
Jansen, FE1
Braun, KP1
de Graeff-Meeder, ER1
Moreira, B1
Lasić, D1
Ivanišević, R1
Uglešić, B1
Cvitanović, MZ1
Glučina, D1
Hlevnjak, I1
Fang, J1
Chen, S2
Tong, N1
An, D1
Mu, J1
Tonic-Ribarska, J1
Haxhiu, A1
Sterjev, Z1
Kiteva, G1
Suturkova, L1
Trajkovic-Jolevska, S1
Wang, W3
Li, S1
Ru, X1
Zheng, J1
Zhu, S1
Albus, K1
Wahab, A1
Heinemann, U6
Kang, HC1
Hu, Q1
Liu, XY1
Xu, F1
Liu, ZG1
Zeng, Z1
Zhu, SQ2
Chen, LJ1
Han, JD1
Chen, ZY1
Ling, S1
Bayhan, T1
Sahin, M1
Yıldırım, I1
Karagöz, T1
Jansen, AJ1
Hunfeld, NG1
van Bommel, J1
Koch, BC1
van Gelder, T1
Tsang, JP1
Poon, WL1
Luk, HM1
Ching, CK1
Mak, CM1
Siu, TS1
Tam, S1
Wong, VC1
Milovanova, OA1
Stepanishchev, IL1
Pykov, MI1
Pobuta, OV1
Golmohammadi, R1
Pejhan, A1
Azhdari-Zarmehri, H1
Mohammad-Zadeh, M1
Akgün, H1
Yücel, M1
Yang, YH1
Baum, L1
Corradini, I1
Donzelli, A1
Antonucci, F1
Welzl, H1
Loos, M1
Martucci, R1
De Astis, S1
Pattini, L1
Inverardi, F1
Wolfer, D1
Caleo, M1
Bozzi, Y1
Verderio, C1
Frassoni, C1
Braida, D1
Clerici, M1
Lipp, HP1
Sala, M1
Matteoli, M1
Arafa, NM1
Abdel-Rahman, M1
El-khadragy, MF1
Kassab, RB1
González, C1
Villena, R1
Hu, C1
He, X1
Snaĭder, NA1
Sychev, DA1
Piliugina, MS1
Dmitrenko, DV1
Bochanova, EN1
Shapovalova, EA1
Zhidkova, IA1
Serkina, AV1
Leppik, IE9
Matin, AA1
Biparva, P1
Amanzadeh, H1
Farhadi, K1
Altay, AB1
Arıcı, Ş1
Umul, M1
Aydın, HH1
Çelebisoy, M1
Vahip, S2
Kesav, P1
V Y, V1
Khurana, D2
Huang, X1
Shen, D1
Peng, B1
Cao, Q1
Chen, G2
Tang, X1
Wen, S1
Yue, J1
Dinapoli, L1
Sperati, F1
Pace, A1
Fabi, A1
Vidiri, A1
Pompili, A1
Carapella, CM1
Emeksiz, HC1
Arga, M1
Steinhoff, BJ2
Maren Staack, A1
Wisniewski, I1
Ozkan, F1
Inci, MF1
Demir, CF1
Xiong, H1
Liu, CT1
Zhang, YH1
Bao, XH1
Jiang, YW1
Wu, XP1
Darling, A1
Poo, P1
Perez-Duenas, B1
Liu, JS1
Li, JB1
Labiner, DM1
Abraham, I4
Haslinger, M1
Seppi, K3
Unterberger, I6
Alge, A2
Windisch, J2
Lechleitner, M6
Bauer, G7
So, CC1
Wong, KF1
Crawford, P3
Polifka, JE1
Friedman, JM1
Malm, H1
Kajantie, E1
Kivirikko, S1
Kääriäinen, H1
Peippo, M1
Somer, M1
Ziyeh, S1
Thiel, T1
Spreer, J1
Klisch, J1
Schumacher, M1
Smyth, MD1
Barbaro, NM1
Baraban, SC1
Galas-Zgorzalewicz, B3
Kurokawa, T1
Davidson, DL2
Mataringa, MI1
May, TW4
Rambeck, B8
Jahromi, SS1
Wentlandt, K1
Piran, S1
Carlen, PL1
Hoppichler, F4
Imai, T1
Lohmann, H1
Bethke, F1
Sunderkötter, C1
Droste, DW1
Gromov, SA4
Kim, KV1
Maksutova, EL1
Zheleznova, EV2
Sokolova, LV2
Geda, G1
Içağasioğlu, D1
Smith, CT2
Hutton, JL4
Giudice, L1
Flynn, KL1
Seale, CG1
Paulson, AJ1
Doñe, S2
Flaster, E2
Ferin, M1
Sauer, MV2
Coyle, H2
Kini, U4
Kuebler, D1
Tanouye, M1
Park, HM1
Kang, SS1
Lee, YB1
Kim, ON1
Lee, SB1
Yim, DS1
Gopaul, VS1
Farrell, K7
Abbott, FS5
Ozkinay, F1
Cogulu, O1
Gunduz, C1
Yilmaz, D1
Kultursay, N1
Stephen, LJ4
Ramsay, RE5
Cantrell, D1
Collins, SD3
Walch, JK2
Naritoku, DK1
Cloyd, JC6
Sommerville, K1
Tütüncüoğlu, S2
Serdaroğlu, G2
Kadioğlu, B1
Taneli, F1
Noyan, A1
Yüncü, Z1
Granneman, GR3
Karabiber, H2
Sonmezgoz, E1
Ozerol, E2
Yakinci, C4
Otlu, B1
Yologlu, S2
Berberoğlu, M1
Pylvänen, V4
Knip, M13
Pakarinen, AJ12
Turkka, J3
Kotila, M4
Rättyä, J8
Myllylä, VV10
Isojärvi, JI18
Kaaja, E2
Kaaja, R1
Hiilesmaa, V2
Giordano, S1
Privitera, MD2
Mattson, RH6
Chadwick, DW14
Neto, W2
Gopaul, S1
Abbott, F1
Dülger, H1
Cesur, Y1
Odabaş, D1
Tuncer, O1
Ataş, B1
Isoherranen, N1
Callenbach, PM1
Jol-Van Der Zijde, CM1
Geerts, AT1
Arts, WF1
Van Donselaar, CA1
Peters, AC3
Stroink, H2
Van Tol, MJ1
Fung, EL1
Tang, NL1
Ho, CS1
Fok, TF1
Shahar, E2
Barak, S1
Queizán, A1
Hernández, F1
Rivas, S1
Irshaid, YM1
Hamdi, AA1
Al Homrany, M1
Seyfert, S1
Bernarding, J1
Braun, J1
Arévalo-Lorido, JC1
Carretero-Gómez, J1
Bureo-Dacal, JC1
Montero-Leal, C1
Bureo-Dacal, P1
Biton, V4
Levisohn, P1
Hoyler, S1
Vuong, A7
Hammer, AE6
Rainesalo, S1
Saransaari, P1
Wirrell, EC2
Grauso-Eby, NL1
Goldfarb, O1
Feldman-Winter, LB1
McAbee, GN1
Balaguer Martínez, JV1
López García, MJ1
Andrés Celma, M1
Contell Villagrasa, A1
Castelló Pomares, ML1
König, SA3
Knolle, J1
Friedewald, S1
Koelfen, W2
Longin, E7
Lenz, T1
Hannak, D1
Yu, KT1
Mills, S1
Thompson, N1
Cunanan, C1
Bosnak, M1
Dikici, B1
Haspolat, K1
Dagli, A1
Dikici, S1
Freitas, A2
Fiore, LA2
Kim, CA1
Levin, IaI1
Tarasov, BA1
Taylor, AE3
Dam, M9
Ayala, R1
Gomez, G1
O'Neill, F1
Tennis, P2
Messenheimer, J2
Johannessen, CU1
Kishore, P1
Rajani Kumar, V1
Satyanarayana, V1
Krishna, DR1
Meshitsuka, S1
Koeda, T1
Muro, H6
Yamanouchi, H1
Ota, T1
Imataka, G1
Nakagawa, E1
Eguchi, M1
Gosakan, R1
von Knorring, N1
Stewart, P1
Sofue, A1
Hayakawa, F1
Nakai, Y1
Toyota, N1
Betts, T2
Yarrow, H1
Dutton, N1
Greenhill, L1
Rolfe, T1
Røste, LS2
Haugen, TB1
Bjørnenak, T2
Saetre, ER2
Tartara, A7
Manni, R5
Morini, R1
Limido, G1
Gatti, G7
Bartoli, A2
Strada, G1
CARRAZ, G1
FAU, R1
CHATEAU, R1
BONNIN, J1
Yerby, MS6
Houge, G1
Fiskerstrand, T1
Øyen, N1
Scheepers, B1
Stodieck, S1
Benardo, LS2
Semczuk-Sikora, A2
Rogowska, W1
Semczuk, M2
Stoll, C1
Audeoud, F1
Gaugler, C1
Bernardin, A1
Messer, J2
Henriksen, T1
Husby, H1
Li, ZP1
Zhang, XY1
Zhong, MK1
Ji, YH1
Ohto, T1
Iwasaki, N1
Tanaka, R1
Hamano, K1
Matsui, A1
di Corcia, G1
Salladini, C1
Morgese, G14
EL Desoky, ES1
Fuseau, E1
EL Din Amry, S1
Cosson, V1
Kaminow, L1
Schimschock, JR1
Doughty, J2
Jacoby, A3
Lavaud, V1
Nicolson, A1
Appleton, RE1
Smith, DF2
Kantola-Sorsa, E1
Isoaho, M1
Matila, R1
Nylund, T1
Bardy, A2
Granström, ML3
Durmaz, Y1
Temel, I2
Mehmet, N1
Bauer, J7
Blumenthal, S1
Stoffel-Wagner, B1
Löfgren, E2
Juntunen, KS1
Päivänsalo, M2
Rautakorpi, I1
Tuomivaara, L1
Ravid, S1
Andraus, J1
Mikkonen, K4
Vainionpää, LK4
Järvelä, IY1
Tapanainen, JS7
Wu, SP1
Shyu, MK1
Gau, CS1
Lin, CJ1
Krishnan, A1
Sahariah, SU1
Kapoor, SK1
Willmore, LJ10
Sato, A1
Katada, S1
Sato, M1
Kobayashi, H1
Fujiwara, T1
Iinuma, K2
Nikolaos, T1
Stylianos, G1
Chryssoula, N1
Irini, P1
Christos, M1
Dimitrios, T1
Konstantinos, P1
Antonis, T1
Winbladh, B1
Källén, B3
Sokolov, AV2
Tischenkova, IF1
Wheless, JW3
Latour, P1
Bentué-Ferrer, D1
Beauplet, A1
Tribut, O1
Allain, H1
Boluk, A1
Guzelipek, M1
Savli, H1
Ozişik, HI1
Kaygusuz, A1
Greco, R6
Latini, G4
De Simone, M2
Easterford, K1
Clough, P1
Kellett, M1
Fallon, K1
Duncan, S5
Luef, GJ2
Waldmann, M2
Sturm, W1
Naser, A2
Zhong, WZ1
Zhao, YJ1
Gao, GM1
Yang, ZH1
Yue, W1
Kohli, K2
Conway, JM2
Sallee, FR1
Reed, MD1
Kearns, GL2
Ding, MP1
Bao, YY1
Liu, ZR1
Xu, LL1
Tapanainen, P1
Mrabet, H1
Mrabet, A1
Zouari, B1
Ghachem, R1
Knorr, M1
Schaper, J1
Harjes, M1
Mayatepek, E1
Rosenbaum, T1
Duncan, R1
Fakhoury, TA2
Messenheimer, JA6
Oner, N1
Kaya, M1
Karasalihoğlu, S1
Karaca, H1
Celtik, C1
Tütüncüler, F1
Lobefalo, L3
Priolo, T1
Rapinese, M2
Gallenga, PE3
Tutor-Crespo, MJ1
Hermida, J1
Abd El-Basset, FZ1
Tohamy, SM1
Zaky, AA1
Mohamed, MS1
Hakky, SM1
El Barbary, NS1
Nassef, NM1
Fischer, W1
Kittner, H1
Regenthal, R1
Kockelmann, E1
Helmstaedter, C1
Smith, MC1
Centorrino, F1
Welge, JA1
Collins, MA1
Weintraub, D1
Spencer, HT1
Hager, M1
Straka, T1
Bazil, CW2
Adams, DJ2
Resor, SR1
Ecevit, C1
Aydoğan, A1
Kavakli, T1
Altinöz, S1
Morgan, CL1
Buchan, S1
Noronha, AL1
Marques, LH1
Borges, MA1
Cendes, F1
Min, LL1
Vinten, J3
Ayres, J1
Fryer, A2
Gorry, J2
Gregg, J2
Nicolaides, P1
Pickering, L1
Tunnicliffe, L1
Vazquez, BR1
Kanner, AM3
Morton, L1
Pellock, JM8
Vestergaard, P1
Rejnmark, L1
Mosekilde, L1
Soufflet, C1
d'Athis, P1
Echenne, B1
Vallée, L1
Bouhours, P1
Grinspan, A1
Solinas, C1
Cook, M2
Agarwal, S1
Gernert, M1
Fedrowitz, M1
Sinclair, DB1
Berg, M1
Breault, R1
Grubben, B1
De Jonghe, P1
Cras, P1
Demey, HE1
Parizel, PM1
Pylaeva, OA1
Petrukhin, AS2
Voronkova, KV1
Nakazato, Y1
Ando, S1
Yamamoto, T1
Tamura, N1
Shimazu, K1
Jiang, DC2
Fukuoka, N1
Tsukamoto, T1
Uno, J1
Kimura, M1
Morita, S1
Morozov, GV1
Semenova, NV1
Slastenko, OA1
Mishchenko, AL1
Oka, E3
Murakami, N2
Ogino, T2
Ohmori, I1
Akiyama, T3
Ito, M2
Armutcu, F1
Gurel, A1
Kanter, M1
Vural, H1
Akyol, O1
Meek, MF1
Broekroelofs, J1
Yska, JP1
Egbers, PH1
Boerma, EC1
van der Voort, PH1
Krauss, GL1
Sale, ME1
Natarajan, S1
Blum, D1
Pack, AM2
Marcus, R1
Holloway, L1
Randall, A2
Seale, C1
Shane, E2
Rinnerthaler, M1
Mueller, J1
Wissel, J1
Poewe, W1
Mørkrid, L2
Mørland, T1
Fukushima, M1
Kotoh, K1
Enjoji, M1
Nakamuta, M1
Nawata, H1
Aishima, S1
Coves-Orts, FJ1
Borrás-Blasco, J1
Navarro-Ruiz, A2
Murcia-López, A1
Palacios-Ortega, F1
Tan, H2
Gürbüz, T1
Dağsuyu, IM1
Attout, H1
Martre, A1
Guez, S1
Series, C1
ten Berg, K1
van Oppen, AC1
Nikkels, PG1
Gittenberger-de Groot, AC1
van der Voet, GB1
Brilstra, EH1
Nakayasu, K1
Nagayama, Y1
Kernitsky, L1
O'Hara, KA2
Jiang, P1
Doueiri, MS1
Dong, E1
Grayson, DR1
Davis, J1
Pinna, G1
Tueting, P1
Costa, E1
Guidotti, A1
Wagner, S1
Hofstädter, F1
Wolff, JE1
Penovich, P1
Nambisan, M1
Surve, T1
Alsdorf, RM1
Makis, AC1
Kateri, MD1
Bourantas, KL1
Papadopoulou, ZL1
Cheung, E1
Wong, V1
Alsdorf, R1
Coyle, TE1
Bair, AK1
Stein, C1
Vajpayee, N1
Mehdi, S1
Wright, J1
Kasturi, L1
Sawant, SP1
Jaffe, SL1
Sanford, M1
Schlingmann, J1
Ikeda, H1
Murakami, T1
Takano, M1
Usui, T1
Kihira, K1
Houben, ML1
Wilting, I1
van Dijken, PJ1
Patrizi, A1
Savoia, F1
Negosanti, F1
Posar, A1
Neri, I1
Ragueneau-Majlessi, I1
Levy, RH10
Brodie, M1
Shah, J1
Grundy, JS1
Tabulina, SD1
O'Brien, MD1
Gilmour-White, SK1
Veggiotti, P1
Cardinali, S1
Granocchio, E1
Avantaggiato, P1
Papalia, G1
Cagnana, A1
Lanzi, G1
Gidal, BE4
Tamura, T1
Hammer, A1
Sorri, I1
Rissanen, E1
Mäntyjärvi, M1
Boggs, JG1
Preis, K1
Artama, M2
Auvinen, A2
Raudaskoski, T1
Isojärvi, I1
Shibata, A1
Hayashi, S1
Noguchi, M1
Parmeggiani, A1
Black, DN1
Althoff, RR1
Daye, K1
Pelletier, CA1
Rath, A1
Naryanan, TJ1
Chowdhary, GV1
Murthy, JM1
Knoester, PD1
Keyser, A4
Renier, WO4
Egberts, AC1
Hekster, YA4
Deckers, CL3
Mimrod, D1
Specchio, LM1
Britzi, M1
Soback, S1
Doose, DR2
Berry, D1
Millington, C1
Seymour, HM1
Glendenning, P1
Motte, J1
Pedespan, JM1
Sevestre, M1
Turcato, Mde F1
Wichert-Ana, L1
Funayama, CA1
Klein, KM1
Reis, J1
Schmidtke, J1
Theisen, FM1
Hebebrand, J1
Takimoto, M1
Irei, M1
Yoshioka, S1
Shibuya, Y1
Kato, M1
Koike, M1
Jing, ZZ1
Giardina, WJ1
Dart, MJ1
Harris, RR1
Bitner, RS1
Radek, RJ1
Fox, GB1
Chemburkar, SR1
Marsh, KC1
Waring, JF1
Hui, JY1
Curzon, P1
Grayson, GK1
Komater, VA1
Ku, Y1
Lockwood, M1
Miner, HM1
Nikkel, AL1
Pan, JB1
Pu, YM1
Bennani, Y1
Durmuller, N1
Jolly, R1
Roux, S1
Sullivan, JP1
Decker, MW1
Lyczkowski, DA1
Pfeifer, HH1
Crespel, A3
Genton, P7
Berramdane, M1
Coubes, P3
Monicard, C1
Baldy-Moulinier, M1
Peterson, GM2
Naunton, M1
Geller, AM1
Hudnell, HK1
Vaughn, BV1
Boyes, WK1
Song, XQ1
Wang, ZP1
Bao, KR1
Zhang, JM1
Yan, CH1
Shen, XM1
Yoshinaga, A1
Ohno, R1
Ishii, N1
Zenkov, LR1
Cuturic, M1
Abramson, RK1
Dorofeeva, MIu2
Ermakov, AIu1
Belousova, ED2
Ab Rahman, AF1
Ibrahim, MI1
Ismail, HI1
Seng, TB1
Orbak, Z1
Kantarci, M1
Koçak, N1
Karaca, L1
Kaddurah, AK1
Holmes, GL4
Epifanio, G1
Auricchio, G1
Federico, RR1
Resicato, G1
Trost, LF1
Wender, RC1
Suter, CC1
Rosenberg, JH1
Brixner, DI1
Von Worley, AM1
Gunter, MJ1
Chez, MG2
Chang, M1
Krasne, V1
Coughlan, C1
Kominsky, M1
Schwartz, A1
Sener, U1
Karaguzel, O1
Ozdamar, O1
Coker, I1
Topbas, M2
Okuyaz, C1
Kanda, J1
Chonabayashi, K1
Watanabe, M3
Arima, N1
Tsudo, M1
Masmoudi, K1
Gras-Champel, V1
Masson, H1
Andréjak, M1
Semah, F1
Towanabut, S1
Tiemkao, S1
Thammasupapong, S1
Kijjarak, R1
Arayawichanon, A1
Poungvarin, N1
Sirimaharaj, S1
Chaisewikul, R1
Asawavichenjinda, T1
Maneesuk, S1
Silpakit, O1
Cavanaugh, JH1
Locke, C1
Klipstein, KG1
Goldberg, JF2
Basic, S1
Hajnsek, S1
Poljakovic, Z1
Basic, M1
Wild, JM1
Robson, CR1
Jones, AL2
Cunliffe, IA1
Castro-Gago, M6
Novo-Rodríguez, MI3
Blanco-Barca, MO1
Urisarri-Ruíz de Cortázar, A1
Rodríguez-García, J1
Rodríguez-Segade, S3
Eirís-Puñal, J3
Orem, A2
Yildirmis, S2
Orhan, F2
Aslan, A1
Scoggan, KA1
Friedman, JH1
Bulman, DE1
Pakarinen, A4
Tana, M1
Serralta, A1
Barcia, JA1
Ortiz, P1
Durán, C1
Hernández, ME1
Alós, M1
Altobelli, E1
Di Mascio, R1
Lattanzi, D1
Guven, MA1
Batukan, C1
Ceylaner, S1
Ceylaner, G1
Uzel, M1
McCabe, PH1
Michel, NC1
McNew, CD1
Lehman, EB1
Seki, A1
Maegaki, Y2
Sugiura, C1
Toyoshima, M1
Akaboshi, S1
Ohno, K2
Voudris, K3
Mastroyianni, S3
Dimou, S2
Skardoutsou, A2
Prassouli, A2
Fattore, C3
Messina, S1
Croci, D2
Mamoli, D2
Paraskevas, GP1
Triantafyllou, NI1
Kapaki, E1
Limpitaki, G1
Petropoulou, O1
Vassilopoulos, D1
Clemens, B1
Ménes, A1
Piros, P1
Bessenyei, M1
Altmann, A1
Jerney, J1
Kollár, K1
Rosdy, B1
Rózsavölgyi, M1
Steinecker, K1
Hollódy, K1
Korovina, SA1
Eroshina, ES1
Cantello, R2
Civardi, C1
Varrasi, C1
Vicentini, R1
Cecchin, M1
Boccagni, C1
Monaco, F4
Aldenkamp, A2
Arzimanoglou, A1
Tallis, R1
Voudris, KA1
Drakatos, A1
Ziauddin, MF1
Yeow, WS1
Maxhimer, JB1
Baras, A1
Chua, A1
Reddy, RM1
Tsai, W1
Cole, GW1
Schrump, DS1
Nguyen, DM1
Tocco, AM1
Ugras, M1
Fudio, S1
Carcas, A1
Piñana, E1
Ortega, R1
Gerstner, T6
Teich, M3
Bell, N4
Dempfle, CE1
Brand, J1
König, S4
Papakonstantinou, E1
Schulpis, K1
Nicolaidou, P1
Georgouli, H1
Kotsalis, H1
Matsinos, Y1
Papadopoulou, A1
Fretzayas, A1
Syriopoulou, V1
Krikos, X1
Karantana, A1
Karpathios, T1
Babayigit, A1
Cakmakci, H1
Mazzucchelli, I1
Arbasino, C1
Sakuta, R1
Tomita, Y2
Ohashi, M1
Nagai, T1
Woelfing, C1
Witsch, M1
Zadikoff, C1
Munhoz, RP2
Asante, AN1
Politzer, N1
Wennberg, R1
Carlen, P1
Lang, A1
Pittschieler, S1
Viinikainen, K1
Mönkkönen, A1
Aikiä, M1
Nieminen, P1
Heinonen, S1
Ozge, A1
Kaleagasi, H1
Yalçin Tasmertek, F1
Michoulas, A1
Tong, V1
Teng, XW1
Chang, TK1
Tolonen, U2
Koivunen, R3
Diegoli, M1
Sartori, I1
Uggetti, C1
Brega, A1
Arbustini, E1
Jamora, D1
Pan, A1
Tan, EK1
Candito, M1
Naimi, M1
Boisson, C1
Rudigoz, JC1
Gaucherand, P1
Guéant, JL1
Luton, D1
Van Obberghen, E1
Tekgul, H2
Demir, N1
Gokben, S1
Taylor, S1
Jaseja, H1
Aycicek, A1
Iscan, A1
Nikitina, TG1
Adamson, VG1
Dyskin, DE1
Prokudin, MIu1
Ivanov, I1
Klein, M1
Green, WH1
Coffey, B1
Koenig, SA2
Buesing, D1
Oehring, R1
Häussermann, P1
Kluger, G1
Lindmayer, F1
Hanusch, R1
Degen, I1
Kuhn, H1
Samii, K1
Jungck, A1
Brückner, R1
Seitz, R1
Boxtermann, W1
Weber, Y1
Knapp, R1
Richard, HH1
Weidner, B1
Kasper, JM1
Haensch, CA1
Fitzek, S1
Hartmann, M1
Borusiak, P1
Müller-Deile, A1
Degenhardt, V1
Korenke, GC1
Hoppen, T1
Specht, U1
Hessen, E1
Reinvang, I1
Ristić, AJ1
Vojvodić, N1
Sindelić, A1
Sokić, D1
Bidzan, L1
El-Khatib, F1
Lee, JW1
Choi, KG1
Chung, HW1
Thajeb, P1
Nikaido, K1
Takayama, R1
Doi, T1
Werner, T1
Treiss, I1
Kohlmueller, D1
Mehlem, P1
Schulze, A1
Dahl, ML1
Kimland, E1
Incecik, F1
Akoglu, E1
Sangün, O1
Melek, I1
Duman, T1
Morton, LD2
Coots, BP1
Goto, S2
Seo, T3
Murata, T1
Nakada, N1
Ueda, N1
Murakami, H1
Kamiyama, N1
Miyamoto, Y1
Aksenova, MG1
Burd, SG1
Kachalin, EIu1
Badalian, OL1
Savenkov, AA1
Tertyshnik, OIu1
Gusev, EI1
Knowlton, RK1
Cofield, SS1
Ver Hoef, LW1
Paige, AL1
Karasik, A1
Kiviti, S1
Galletti, F1
Rossi, C1
Beyenburg, S1
Back, C1
Diederich, N1
Lewis, M1
Rao, S1
Sein, K1
Haddad, PM1
Cognato, Gde P1
Bruno, AN1
da Silva, RS1
Bogo, MR1
Sarkis, JJ1
Gomceli, YB1
Cavdar, L1
Sanivar, F1
Inan, LE1
Nicolai, J2
Aldenkamp, AP3
Huizenga, JR1
Teune, LK1
Olsen, KB1
Kocak, S1
Girisgin, SA1
Gul, M1
Cander, B1
Kaya, H1
Kaya, E1
Szupera, Z2
Prabhakar, S1
Sahota, P1
Kharbanda, PS1
Siali, R1
Jain, V1
Lal, V1
Simister, RJ1
McLean, MA1
Barker, GJ1
Zgorzalewicz, M2
Semba, H1
Sugawara, H1
Otsuka, M1
Ueki, A1
Eggers, AE1
Rosenberg, G1
Yokoyama, A1
Saito, Y1
Gunes, A1
Bilir, E1
Zengil, H1
Babaoglu, MO1
Bozkurt, A1
Yasar, U1
Pagulayan, KF1
Temkin, NR2
Machamer, JE1
Dikmen, SS1
Serafini, A1
Davy, JM1
Balbe, M1
Quenby, SM1
Anin, S1
Bates, MD1
Chadwick, D8
Vince, GS1
Neilson, JP1
Sun, W2
Cowling, BJ1
Shaw, JE1
Butler, E3
Parker, P1
Hitiris, N1
Leach, VM1
Wilson, EA1
Kim, JY1
Jiruska, P1
Proks, J1
Otáhal, J1
Mares, P6
Malek, R1
Cannizzaro, E1
Albisetti, M1
Wohlrab, G1
Schmugge, M1
Dannhardt, G1
Kiefer, W1
Mikati, MA1
Tarabay, H1
Khalil, A1
Rahi, AC1
El Banna, D1
Najjar, S1
Otoul, C1
De Smedt, H1
Tilz, C1
Wang-Tilz, Y1
Jünemann, A1
Michelson, G1
Cross, H1
Ferrie, C1
Lascelles, K1
Livingston, J1
Mewasingh, L1
Carrim, ZI1
McKay, L1
Sidiki, SS1
Lavy, TE1
Borroni, B1
Costanzi, C1
Zulli, R1
Mardighian, D1
Gasparotti, R1
Padovani, A1
Kustra, RP1
Chicharro, AV1
de Marinis, AJ1
Wang, YQ1
Bai, XR1
Birnbaum, AK1
Ahn, JE1
Brundage, RC1
Hardie, NA1
Savica, R1
Mazzaglia, G1
Innocenti, F1
Brignoli, O1
Cricelli, C1
Caputi, AP1
Musolino, R6
Spina, E2
Trifirò, G1
Eaton, B1
Gamble, C1
Shackley, P1
Vanoli, A1
Pelc, K1
Boyd, SG1
Cheron, G1
Dan, B1
Buchmüller, L1
Burr, W4
Borhani Haghighi, A1
Sabayan, B1
Rathmalgoda, C1
Potter, JM1
Lueck, CJ1
Jedrzejczak, J1
Kuncíková, M1
Magureanu, S1
Reynolds, MF1
Sisk, EC1
Rasgon, NL1
Scholl-Bürgi, S2
Ernst, B1
Karall, D2
Ebenbichler, CF2
Sikma, MA1
Mier, JC1
Meulenbelt, J1
Lee, SG1
Kim, JH1
Joo, JY1
Kwon, OH1
Mihajlovic-Madzarevic, V1
Pappas, P1
Fukushima, Y6
Hashimoto, N1
Higa, Y1
Carr, RB1
Chakraborty, A1
Das, K1
Gungor, S2
Yücel, G1
Akinci, A1
Tabel, Y1
Ozerol, IH1
Kurul, S1
Unalp, A1
McFarland, R1
Hudson, G1
Green, SH2
Hodges, S1
McKiernan, PJ1
Ramesh, V1
Makita, T1
Nishihara, S1
Kitamura, Y1
Gomita, Y3
Demirkaya, E1
Kul, M1
Gul, D1
Gokçay, E4
Hagiwara, T1
Ueda, K3
Yamauchi, T1
Nagata, S1
Ando, Y1
Murphy, R1
Daugherty, J1
Houry, D1
Delima, SI1
Walsh, LE1
Golomb, MR1
Ferrie, CD1
Grünewald, RA1
Livingston, JH1
Panayiotopoulos, CP1
Oberheim, NA1
Tian, GF1
Peng, W1
Takano, T1
Ransom, B1
Nedergaard, M1
Faye, M1
N'Diaye, M1
Gueye Diagne, MC1
SarrNiang, NT1
Yam, AA1
Guzeva, VI1
Fomina, MIu1
Korostovtsev, DD1
Guzeva, VV1
Guzeva, OV1
Krogenaes, AK1
Stien, A1
Oskam, IC1
Lyche, JL1
Dahl, E1
Thomassen, RF1
Sweeney, T1
Ropstad, E1
Lan, MJ1
Yuan, P1
Manji, HK1
McMahon, DJ1
Elwakkad, AS1
El Elshamy, KA1
Sibaii, H1
Schoenherr, E1
Engl, J1
Laimer, M1
Lipatova, LV1
Rodríguez-Pinilla, E1
Mejías, C1
Prieto-Merino, D1
Fernández, P1
Martínez-Frías, ML1
Jakovljevic, MB1
Todorovic, N1
Hiilesmaa, VK1
Bardy, AH1
Teramo, KA1
Coulter, DL4
Allen, RJ2
Tollefson, G1
Ware, S1
Millward-Sadler, GH1
Parnas, J4
Gram, L16
Flachs, H7
Inoue, R1
Doss, M1
Becker, U1
Peter, HJ1
Kaffarnik, H1
Maheshwari, MC9
Rump, S1
Drysdale, HC1
Jones, LF1
Minns, RA2
Brown, JK3
Blackwood, DH2
McQueen, JK2
Pei, YQ1
de Wolff, FA1
van Kempen, GM1
Robert, E6
Guibaud, P1
Bjerkedal, T1
Czeizel, A1
Goujard, J1
Mastroiacova, P1
Nevin, N1
Oakley, G1
Fichsel, H4
Schmidt, D7
Deisenhammer, E3
Schwarzbach, H1
Sommer, R2
Chapman, A1
Keane, PE2
Meldrum, BS2
Simiand, J2
Vernieres, JC2
Castilla, E1
Meijer, JW4
Binnie, CD4
Debets, RM1
van Parys, JA1
de Beer-Pawlikowski, NK1
Tokola, RA1
Neuvonen, PJ2
Dowling, SJ1
Kugoh, T3
Hosokawa, K3
Siemes, H2
Meinardi, H7
Löfkvist, E1
Mauguiere, F1
Myslobodsky, MS1
Mintz, M1
Douglas, R1
Lundberg, B2
Nergårdh, A4
Boréus, LO1
Feuerstein, J1
Revol, M1
Roger, J4
Sallou, C1
Truelle, JL1
Vercelletto, P1
Weber, M1
Krause, KH2
Berlit, P1
Lee, SI2
Meldrum, B1
Kritzler, RK1
Vining, EP4
Plotnick, LP1
Bailey, CJ1
Pool, RW1
Poskitt, EM1
Harris, F2
Matsuo, T4
Nau, H10
Morre, M1
Roncucci, R1
Johnston, D1
Chayasirisobhon, S1
Russell, M1
Dahlquist, NR1
Mellinger, JF1
Klass, DW1
Koch, S5
Göpfert-Geyer, I1
Jäger-Roman, E4
Jakob, S2
Huth, H1
Hartmann, A1
Rating, D6
Helge, H7
Marescaux, C7
Warter, JM5
Laroye, M1
Rumbach, L5
Micheletti, G5
Koehl, C2
Imler, M4
Kurtz, D3
Curran, AC1
Heldenberg, D1
Harel, S1
Holtzman, M1
Levtow, O1
Tamir, I1
ten Kate, LP1
Swagemakers, ML1
Weemhoff, RA1
van Eck, JH1
Otani, K4
Nomura, Y2
Ogawa, Y2
Bentsen, KD5
Veje, A1
Cramer, JA5
Bennett, DM1
Orr, JM2
Ferguson, S2
Godolphin, WJ1
Rowan, AJ1
Hertrich, O1
Goedhart, D1
Eeg-Olofsson, O1
Lundström, A1
Hamp, SE1
Albani, F8
Cortelli, P1
Gobbi, G3
Baruzzi, A12
Philbert, A3
Pedersen, B4
Friis, ML2
Hvidberg, EF1
Karlsen, RL1
Kett, K1
Henriksen, O4
Escorihuela, R1
Sandiumenge, J1
Fukuda, T1
Kuroki, Y1
Thurston, JH2
Carroll, JE1
Dodson, WE2
Hauhart, RE2
Tasch, V2
Robert, JM1
Lapras, C1
Turnbull, DM3
Rawlins, MD3
Weightman, D2
Wilder, BJ9
Karas, BJ1
Hammond, EJ2
Perchalski, RJ3
Majkowski, J3
Kaplan, H1
Brandt, C2
Chabrier, G3
Dreifuss, FE6
Trunfio, C1
Fazio, A2
Oteri, G3
Di Perri, R10
Wyllie, E2
Wyllie, R2
Rothner, AD2
Erenberg, G2
Cruse, RP2
Boncinelli, L1
Paganini, M6
Campostrini, R6
Arnetoli, G5
Zappoli, R5
Murata, Y1
Irimichi, H1
Okamoto, M1
Hirose, K1
Hayashi, R1
Miyamaru, N1
Rimmer, EM1
Buss, DC1
Routledge, PA2
Richens, A12
Conran, MJ1
Kearney, PJ1
Callaghan, N7
Murphy, D1
Collard, M2
Reynolds, EH3
O'Dwyer, R1
Keating, J1
Fröscher, W6
Penin, H3
Froescher, W2
Gugler, R4
Niesen, M1
Hoffmann, F4
Luck, W1
Moreland, TA2
Albright, PS1
Bruni, J8
Suria, D1
Sivenius, J1
Ikeda, N1
Mitsudome, A3
Ogata, H2
Ohfu, M2
Arthuis, M2
Jeavons, PM9
Trimble, MR3
Thompson, PJ1
Loiseau, P5
Ghose, K1
Bantz, EW1
Morselli, PL1
Guyot, M1
Brachet-Liermain, A1
Moroni, F2
Maresová, D2
Pohl, M1
Koryntová, H1
Seidl, J1
Velísek, L1
Vergnes, M2
Kochen, W2
Sprunck, HP1
Tauscher, W1
Klemens, M1
Hendel, J1
Winkel, P1
Mondadori, C2
Schmutz, M2
Baltzer, V1
Tsanaclis, LM1
Allen, J1
McLean, S1
Millingen, KS1
Notani, M1
Kawamura, H1
Amano, K1
Tanikawa, T1
Kawabatake, H1
Iseki, H1
Shiwaku, T1
Nagao, T1
Kakinoki, Y1
Kitamura, K1
Ohtani, Y2
Matsuda, I2
Scanabissi, E1
Dal Pozzo, D1
Galloni, C1
Mengoli, G1
Calivà, R1
Porter, RJ3
Theodore, WH3
Dinesen, H1
Andersen, T1
Hedges, A2
Makki, KA2
Ruprah, M1
Wilson, JF1
Valenza, T3
Targioni, G1
De Paiva, VJ1
Subirana, A1
Subirana, M1
Stoll, KD2
McCown, TJ1
Greenwood, RS2
Frye, GD1
Breese, GR1
Ashok, PP1
DiLiberti, JH1
Farndon, PA1
Dennis, NR1
Curry, CJ1
Heazlewood, V1
McKauge, L1
Tyrer, JH2
Butlin, AT3
Danta, G3
Cook, ML2
Yu, HY1
Otten, N1
Hall, K1
Irvine-Meek, J1
Leroux, M1
Budnik, D1
Seshia, S1
Schoeman, JF2
Elyas, AA3
Brett, EM3
Lascelles, PT2
Niermeijer, MF1
Angelastro, R1
Bartelli, M1
Jibiki, I2
Bauman, AW1
Eastham, RD1
Jancar, J1
Similä, S3
von Wendt, L3
Linna, SL2
Schapel, GJ3
Doecke, CJ1
O'Reilly, WJ1
Reece, PA1
Rischbieth, RH3
Sansom, LN2
Stanley, PE2
Nitsche, V1
Cowen, J1
Gallitto, G5
Morgante, L3
Natoli, M1
Serra, S1
Read, T1
Reid, M1
Sansom, L1
Marghescu, S1
Neukam, D1
Leary, PM2
Morris, S1
Puukka, M1
Puukka, R1
Reunanen, M1
Coeckelberghs, M1
van Caillie-Bertrand, M1
Bultinck, J1
Clara, R1
Haidukewych, D7
Rodin, EA5
Reynolds, NC2
Kirkham, DB1
Kober, A1
Olsson, Y1
Sjöholm, I1
Kumps, A1
Mardens, Y1
Beran, RC1
Köhler, E1
Quednow, B1
Walther, H4
von Unruh, GE2
Jancik, BC2
Hoffman, F1
Wilkins, AJ2
Darby, CE2
Addy, DP1
Kapetanović, IM2
Kupferberg, HJ3
Theodore, W2
Schulman, E1
Penry, JK8
Shakir, RA2
Johnson, RH2
Lambie, DG2
Melville, ID1
Nanda, RN2
Moglia, A1
Verri, AP1
Savoldi, F1
Bo, P1
Klotz, U3
Schweizer, C1
Russo, LS1
Fiedlerová, D1
Grosmanová, A1
Aminoff, MJ1
Gentile, A1
Caruso, C1
Celentano, I1
Suganuma, T2
Ishizaki, T3
Chiba, K3
Hori, M2
Egger, J1
Saavedra, I1
Concha, G1
Valenzuela, A1
Galdames, D2
Aguilera, L2
Scollo-Lavizzari, G2
Dhillon, S1
Windorfer, A3
Hermannsdörfer-Tröltzsch, G1
Kienholz, M1
Maier-Lenz, H1
Löhr, W1
Arranz Peña, MI1
Häuser, I1
Diehl, LW1
Cairney, P1
Hornabrook, RW1
Ainsworth, JW1
Dugas, M1
Brunod, R1
Knott, C1
Hamshaw-Thomas, A1
Reynolds, F1
Wittfoht, W1
Schäfer, H2
Jakobs, C2
Nisticò, G1
Pisarski, W2
Lysakowska-Sernicka, K1
Bilińska-Nigot, B1
Woźniak, J1
Tokarz, A1
Rosadini, G2
Ferrillo, F1
Rodriguez, G1
Sannita, WG3
Rabending, G1
Beier, R1
Cammann, R1
Du Chesne, HJ1
Gebelt, H1
Grimmberger, M1
Hobusch, D1
Klepel, H2
König, K1
Knaape, HH1
Michalowski, B1
Müller, D1
Oettinger, B1
Suhr, G1
Todt, H1
Vesper, J1
Wendt, U1
Zettler, H1
Armijo, JA3
Valiente, R1
Herranz, JL4
Piredda, S1
Mutani, R2
Mastropaolo, C1
Tondi, M1
Miura, H5
Roman, EJ1
Ponniah, P1
Lambert, JB1
Buchanan, N1
Pavone, L1
Klose, G1
Mollica, F1
La Rosa, M1
Greten, H1
Fung, K1
Chambers, BR1
Alvarez, N1
Hazlett, J1
Courcelle, R1
Loisseau, P1
Martínez-Lage, JM1
Sheppard, I1
Godolphin, W1
Arteaga, R2
Patel, IH1
Venkataramanan, R1
Viswanathan, CT1
Ojemann, LM1
Coquillat, G1
Batshaw, ML1
Brusilow, SW1
Vanderzant, C1
Fitz, R1
Holmes, G1
Greenberg, HS1
Sackellares, JC1
Wolfendale, L1
Staudt, F1
Helwig, H1
Boldyrev, AI1
Keene, DL1
Metrakos, K1
Watters, GV1
Sherwin, A1
Engel, J2
Troupin, AS1
Crandall, PH1
Sterman, MB1
Wasterlain, CG1
Barr, RD1
Copeland, SA1
Stockwell, ML1
Morris, N1
Kelton, JC1
Marty, JJ1
Kilpatrick, CJ3
Moulds, RF3
Szabová, I1
Benko, J1
Brozmanová, M1
Cacková, M1
Vajda, P1
Asconapé, JJ2
Tabuchi, T1
Wagatsuma, T1
Nakazawa, Y1
Martín, A1
Benavides, J1
Ugarte, M1
Gupta, AK1
Schneble, H1
Galvani, I1
Seino, M1
Kakegawa, N1
Gastaut, H2
Iemolo, F1
Biraghi, M1
Cusi, C1
Nespolo, A1
Avanzini, G4
Olivi, F1
Pantaloni, M1
Herzer, H1
Perlwitz, R1
Herzer, R1
Schobben, F2
van der Kleijn, E2
Vree, TB1
Tandon, RK1
Brickley, JJ1
Sutherling, WW1
Johnson, RN2
Kido, H1
Beaumanoir, A2
Nahory, A1
Potoliccio, S1
Findji, F1
Catani, P1
Redenbaugh, JE1
Sherard, ES1
Steiman, GS1
Couri, D1
Villarreal, HJ4
Monks, A2
Berman, W1
Chang, CW1
Bleck, TP1
Meyer, MC1
Cloyd, J1
Garnett, WR1
Schiffer, JR1
Graf, WD1
Pippenger, CE3
Shurtleff, DB1
Christianson, AL1
Chesler, N1
Kromberg, JG1
Davis, R1
Peters, DH1
McTavish, D1
Macdonald, RL2
Kelly, KM2
Collins, AF1
Dover, GJ1
Luban, NL1
Gambardella, A1
Zappia, M1
Valentino, P1
Quattrone, A1
Rundfeldt, C3
Koch, R1
Richter, A1
Mevissen, M1
Gerecke, U1
Kürekçi, AE2
Alpay, F1
Tanindi, S2
Işimer, A1
Sayal, A1
Sewell, AC2
Böhles, HJ1
Herwig, J1
Demirkol, M1
Devinsky, O1
Leppik, I1
Dean, C1
Gates, J1
Papazian, O2
Cañizales, E1
Alfonso, I1
Archila, R1
Duchowny, M1
Aicardi, J2
Liakopoulou, E1
Blau, CA1
Josephson, B1
Wolf, JA1
Fournarakis, B1
Raisys, V1
Dover, G1
Papayannopoulou, T1
Stamatoyannopoulos, G1
Saussu, F1
de Barsy, T1
Yuksel, A5
Senocak, D1
Sozuer, D1
Keskin, G1
Dirican, A2
Cenani, A3
Yalcin, E4
Buzan, RD1
Firestone, D1
Thomas, M2
Dubovsky, SL1
Jefferson, JW1
Pacifici, R2
Paris, L2
Di Carlo, S1
Bacosi, A1
Pichini, S2
Zuccaro, P2
Fueta, Y2
Tancredi, V1
Avoli, M2
Yasuda, K1
Nakasa, H1
Niimi, H1
Svinarov, DA1
Kaufman, J1
O'Shaughnessy, IM1
Adkison, KD1
Ojemann, GA2
Rapport, RL1
Dills, RL1
Shen, DD2
Sheth, RD1
Wesolowski, CA1
Jacob, JC1
Penney, S1
Hobbs, GR1
Riggs, JE1
Bodensteiner, JB3
González-Darder, JM2
García-Teno, M1
Sarslan, O1
Devranoğlu, K1
Hattat, N1
Kerrick, JM1
Wolff, DL1
Graves, NM2
Ratti, MT1
Tatsuhara, T2
Sugimoto, T6
Woo, M6
Nishida, N6
Murakami, K6
Yamaguchi, Y1
Hoare, P1
Mann, H1
Zelnik, N1
Fridkis, I1
Gruener, N1
Badalian, LO2
Temin, PA2
Medvedev, MI2
Mukhin, KIu3
Iskander, MB2
Kharlamov, DA1
Veselov, NK2
Kodama, Y6
Kuranari, M6
Kodama, H5
Koike, Y1
Yasunaga, F1
Fujii, I2
Aiken, TC1
Collin, RC1
Bayer, A1
Thiel, HJ2
Zrenner, E2
Paulus, W2
Ried, S2
Konishi, T2
Naganuma, Y2
Hongou, K2
Murakami, M2
Yamatani, M2
Okada, T2
Eirís, JM1
Lojo, S1
Del Río, MC2
Novo, I1
Bravo, M1
Pavón, P1
Wohlhüter, M1
Stoll, AL1
Banov, M1
Kolbrener, M1
Mayer, PV1
Tohen, M1
Strakowski, SM1
Castillo, J1
Suppes, T1
Cohen, BM1
Ikeda, K1
Moriyasu, H1
Yasaka, M1
Oita, J1
Yamaguchi, T3
Korinthenberg, R2
Wehrle, L1
Baganz, MD1
Dross, PE1
Bavoux, F1
Fournier-Perhilou, AI1
Wood, C1
Francoual, C1
Boccara, JF1
Anyanwu, E1
Harding, GF3
Bernus, I2
Dickinson, RG5
Hooper, WD3
Majeed, T1
O'Connell, A1
Oliveira, DB1
Lackner, TE1
Delgado, MR3
Riela, AR1
Mills, J1
Browne, R1
Roach, ES1
Hess, CW1
Bourgeois, B2
Kishi, T2
Fujita, N2
Kawaguchi, H1
Ishimae, M1
Hubert, A1
Bonneau, D1
Couet, D1
Berthier, M1
Oriot, D1
Larrègue, M1
Wagner, ML1
Remmel, RP2
Shumaker, RC1
Ward, DL1
Perhach, JL2
Liu, XM1
Ruan, XZ1
Cai, Z1
Lammers, MW2
Wijsman, DJ1
van Lier, H1
Darius, J1
Meyer, FP4
Landau, J1
Baulac, M1
Durand, G1
de Billy, A1
Philippon, J1
Lancman, ME1
Alldredge, BK1
Knutsen, AP1
Ferriero, D1
Despland, PA2
Kryzhanovskiĭ, GN1
Karpova, MN1
Abrosimov, IIu1
Pankov, OIu1
Lakinina, MV1
Gianelli, M1
Schiavella, MP1
Naldi, P1
Torta, R1
Verzé, L2
Spencer, N1
Maly, M1
Pitterle, M1
Williams, E1
Jones, J1
Silva, C1
Chesta, J1
Plioplys, AV1
Kastner, T1
Finesmith, R1
Walsh, K1
McKee, PJ4
Blacklaw, J2
Forrest, G1
Gillham, RA3
Walker, SM1
Connelly, D1
Bourgeois, BF5
Knowles, WD1
Haj-Yehia, A1
Badir, K1
Hadad, S1
Martin, PJ1
Millac, PA1
Parent, X1
Marzullo, C1
Gutbub, AM1
Brenner, S1
Wolf, R1
Landau, M1
Politi, Y1
Freeman, JM3
Cost, S1
Rha, JH1
Lee, KH1
Chong, WS1
Shin, SG1
Myung, HJ1
Uematsu, T1
Mizuno, A1
Ninchoji, T1
Fujii, K1
Nakashima, M1
Thisted, E1
Ebbesen, F2
Dooley, JM1
Camfield, PR1
Camfield, CS1
Gordon, KE1
Fraser, AD1
Hurst, DL1
Balestra, V1
DiBon, G1
Hassan, KM1
Kossak, BD1
Schmidt-Sommerfeld, E1
Schoeller, DA1
Rinaldo, P1
Penn, D1
Tonsgard, JH1
Vorum, H1
Honoré, B1
Kurowski, HL1
Gospe, SM1
Zeman, FJ1
Grivetti, LE1
Pierce, MW1
Shu, VS1
Melegh, B3
Pap, M1
Bock, I1
Rebouche, CJ1
Apperson Hansen, C1
Sasaki, T1
Kobayashi, Y2
Kondo, T4
Kan, R1
Takeda, A2
Nakane, Y1
Tokuda, K1
Kodani, N1
Herranz Fernández, JL2
Macdonell, RA1
Bladin, PF4
Gunatilake, SB1
Momota, T1
Mimasu, S1
Kuniya, T1
Alpherts, WC1
Blennow, G2
Elmqvist, D1
Heijbel, J2
Nilsson, HL1
Sandstedt, P2
Tonnby, B2
Wåhlander, L1
Wosse, E1
Varagić, VM1
Lević, Z2
Berg, I2
Butler, A1
Ellis, M1
Foster, J1
Nevoral, J1
Janda, J1
Hanika, J1
Svec, M1
Honzová, S1
Larkin, JG3
Brodie, AF1
Percy-Robb, IW1
Wallace, SJ3
Alving, J1
Spencer, SC1
Hosking, G1
Sharpe, PC1
Trimble, ER1
Donnai, D1
Estienne, M1
Pitterle, ME2
Spencer, NW1
Maly, MM1
Botha, JH1
Gray, AL1
O'Connell, MT1
Doheny, MH1
Darsot, S1
Niketić, V1
Ristić, S1
Saicić, ZS1
Spasić, M1
Buzadzić, B1
Stojković, M1
de Silva, M1
MacArdle, B1
McGowan, M1
Hughes, E1
Stewart, J1
Neville, BG1
Johnson, AL2
Chen, YJ1
Kang, WM1
So, WC1
Kubova, H2
Lanstiakova, M1
Mockova, M1
Vorlicek, J2
Bryant, AE1
Laatikainen, TJ2
Juntunen, KT1
Yamaoka, K2
Takenawa, H1
Tajiri, K1
Yamane, M1
Kadowaki, K1
Marumo, F1
Sato, C1
Salinsky, MC1
Oken, BS1
Binder, LM1
Zeffiro, T1
Fazilat, S1
DeCarli, C1
Gigli, GL1
Scalise, A1
Pauri, F1
Silvestri, G1
Diomedi, M1
Grazia Pomponi, M1
Masala, C1
Browne, RH1
Bergen, DC1
Ristanovic, RK1
Waicosky, K1
Hoeppner, TJ1
Gonzalez, IG1
Martin Luquero, M1
Marcos Martinez, L1
Gargallo Fernandez, MA1
Rodriguez Macias, KA1
Beversdorf, D1
Allen, C1
Nordgren, R1
López Alemany, M1
Ferrer Tuset, C1
Bernácer Alpera, B1
Davies, JA1
Yamatogi, Y1
Ohtahara, S1
Yamashita, S1
Furuno, K2
Böhles, H1
Wenzel, D1
Gordon, K1
Bawden, H1
Camfield, P1
Mann, S1
Orlik, P1
Eriksson, AS1
Hoppu, K1
Boreus, L1
Legarda, SB1
Booth, MP1
Fennell, EB1
Maria, BL1
Chiba, S1
Ashikari, Y1
Sakata, T1
Lösche, G1
de Juan Frigola, J1
Crespo Hernández, M1
Braga Hernández, S1
Sälke-Kellermann, A1
Ståhle, L1
Alm, C1
Ekquist, B1
Lundquist, B1
Sözüer, DT2
Barutçu, UB1
Karakoç, Y1
Onen, S1
Prevey, ML2
Delaney, RC1
Cattanach, L1
Collins, JF1
Michaud, L1
Gottrand, F1
Turck, D1
Poher, M1
Lecomte-Houcke, M1
Farriaux, JP2
Wood, BP1
Shinoda, M1
Akita, M1
Hasegawa, M1
Hasegawa, T1
Nabeshima, T1
Yukawa, E8
Aoyama, T6
Stern, MJ1
Cook, MA1
Shramek, JK1
de Silva, RD1
Raguthu, S1
Jürgens, U2
Henskens, YM1
Strooker, H1
van den Keijbus, PA1
Veerman, EC1
Nieuw Amerongen, AV1
Milovanovic, DD2
Stevanovic, HL1
Jovic, N1
Koseoglu, V1
Espinasse, M1
Manouvrier, S1
Boute, O1
Zaizen, T1
Polásek, R1
Slamberová, R1
Armand, V2
Louvel, J2
Pumain, R2
Ronco, G1
Villa, P1
Hiraoka, A1
Arato, T1
Tominaga, I1
Maksumova, EL1
Muzychenko, AP1
Rosenfeld, WE3
Walker, SA1
Nayak, RK2
Liao, S1
Kramer, LD1
Anderson, G1
Palmer, M1
Eguchi, T1
Rizkallah, E1
Kluczyński, A1
Kleinrok, Z2
Hockey, A1
Bower, C1
Goldblatt, J1
Knowles, S1
Theis, JG1
Koren, G2
Daneman, R1
Sherwin, AL1
Menzano, E1
Cortez, M1
Hwang, P1
Bayer, AU1
Dichgans, J1
Kuehn, M1
Easter, D1
O'Bryan-Tear, CG1
Verity, C1
Miranda Mallea, J1
Güemes Heras, I1
Barbero Aguirre, P1
Menor Serrano, F1
García Tena, J1
Moreno Rubio, JA1
Mulas Delgado, F1
Chapman, DP1
Giles, WH1
Geisler, J1
Berntsen, H1
Geisler, S1
Lønning, PE1
Applegate, CD1
Samoriski, GM1
Ozduman, K1
Edson, A1
Yasumoto, S2
Ogawa, A2
Hirose, S3
Hönnicke, LR1
Martins, LT1
Carreiro, JE1
Cat, R1
Stahl, MM1
Neiderud, J1
Vinge, E1
Girvan, J1
Jamieson, V1
Jones, T1
Hassanzadeh, A1
Mawlud, K1
Atakil, D1
Dogu, O1
Baybas, S1
Arpaci, B1
Anderson, GD3
Lin, YX1
Berge, C1
Rostock, A1
Tober, C1
Bartsch, R1
Unverferth, K1
Wolf, HH1
Inglese, CM1
Meyer, JF1
Antonopolous, J1
Rust, RS1
Domizio, S2
Angelozzi, B1
Sabatino, G2
Panagopoulos, GR1
Thomaides, T1
Tagaris, G1
Karageorgiou, CL1
Cranor, CW1
Sawyer, WT1
Carson, SW1
Early, JJ1
Corman, CL1
Leung, NM1
Guberman, AH1
Navarro-Quesada, FJ1
Lluch-Fernández, MD1
Vaquero-Abellán, M1
Marchante-Serrano, C1
Jiménez, C1
Dunaevskaia, GN1
Filin, VA1
Aĭvazian, SO1
Glue, P1
Banfield, CR1
Mather, GG1
Racha, JK1
Altunbaşak, S2
Baytok, V1
Tasouji, M1
Hergüner, O1
Burgut, R1
Kayrin, L1
Honda, T1
Ohdo, S4
Higuchi, S5
Murialdo, G1
Magri, F1
Sampaolo, P1
Copello, F1
Gianelli, MV1
Gazzerro, E1
Rollero, A1
Deagatone, C1
Ferrari, E1
Polleri, A1
Jacobs, HS1
Liukkonen, E1
Chung, S1
Choi, J1
Hyun, T1
Rha, Y1
Bae, C1
Scheen, AJ1
Branten, AJ1
Wetzels, JF1
Weber, AM1
Koene, RA1
Park-Matsumoto, YC1
Tazawa, T1
To, H2
Pedley, TA1
Vaz, J1
Kulkarni, C1
David, J1
Joseph, T1
Kennedy, BT1
Haller, JS1
Blumer, D1
Himmelhoch, J1
Salgueiro, CA1
Ling, FW1
Tekay, A2
Mankin, KP1
Scanlon, M1
Katayama, H2
Yoshitomi, H2
Yoshida, H2
Kimoto, H2
Kamiya, A2
Akimura, T1
Muta, Y1
Tomoda, Y1
Nieto Barrera, M1
López Alcaide, MI1
Candau Fernández-Mensaque, R1
Ruiz del Portal Bermudo, L1
Rufo Campos, M1
Correa Charro, A1
Belmonte, A1
Canapicchi, R1
Casalini, C1
Suominen, K1
Repo, M1
Sokolova, S1
Schmitz, D1
Donnet, A1
Bartolomei, F2
Otoom, S1
Tian, LM1
Alkadhi, KA2
De Sarro, GB2
Berlinghieri, MC1
Musumeci, SA1
David, E1
Dominijanni, A1
Gulletta, E1
Bates, ER1
Read, CL1
Stolarek, IH1
Paul, A1
Suemaru, K1
Yasuhara, K1
Yao, K1
Araki, H1
Ballaban-Gil, K1
Callahan, C1
O'Dell, C1
Pappo, M1
Moshé, S1
Shinnar, S2
Bradaï, R1
Proudfoot, AT1
Yamagata, T1
Momoi, MY1
Murai, K1
Ikematsu, K1
Suwa, K1
Sakamoto, K1
Fujimura, A4
Caldiroli, E1
Marino, F1
Cosentino, M1
De Ponti, F1
Fietta, AM1
Mazzone, A1
Zibetti, A1
Lecchini, S3
Frigo, GM4
Mayer, T1
Reker, M1
Okutan, V1
Sarici, U1
Altunbas, A1
Pavlakis, SG1
Chusid, RL1
Roye, DP1
Nordli, DR2
Sánchez-Alcaraz, A1
Quintana, MB1
López, E1
Taverna, S1
Mantegazza, M1
Franceschetti, S3
Cepelak, I1
Zanić Grubisić, T1
Mandusić, A1
Rekić, B1
Lenicek, J1
Garaizar, C1
Pérez-García, J1
Gil-Antón, J1
Prats, JM1
Marciani, MG1
Spanedda, F1
Bassetti, MA1
Romigi, A1
Mattia, D1
Eberle, AJ1
Schlienger, RG2
Oh, PI1
Knowles, SR1
Shear, NH2
Shapiro, LE1
De Vivo, DC1
Shields, WD1
Stafstrom, CE1
Tein, I2
Couceiro, J1
Camiña, F1
Pita-Calandre, E1
Rodríguez-López, CM1
Cano, MD1
Peña-Bernal, M1
Morris, RG2
Black, AB2
Harris, AL1
Batty, AB1
Sallustio, BC1
Basciani, F7
Feely, M1
Zeller, JA1
Schlesinger, S1
Runge, U1
Kessler, C1
Cengiz, M3
Seven, M3
Cengiz, S1
Kafali, G1
Erselcan, T1
Tanzer, F1
Vainionpää, L1
Lanning, P2
Göbel, R1
Görtzen, A1
Bräunig, P1
Kis, B1
Mezei, Z1
Gecse, A1
Telegdy, G1
Vécsei, L1
Schwaninger, M1
Ringleb, P1
Winter, R1
Kohl, B1
Fiehn, W1
Rieser, PA1
Walter-Sack, I1
Johnston, HF1
El Desoky, E1
Kandil, MR1
Afifi, AH1
Mostafa, OA1
Siegel, H1
Kelley, K1
Stertz, B1
Reeves-Tyer, P1
Flamini, R1
Malow, B1
Ko, D1
Shuper, A1
Gutman, A2
Mimouni, M1
Sarkisian, MR1
Rattan, S1
D'Mello, SR1
LoTurco, JJ1
Baggot, PJ1
Kalamarides, JA1
Shoemaker, JD1
McCoy, GB1
Serrano, BB1
García Sánchez, MJ1
Otero, MJ1
Buelga, DS1
Serrano, J1
Domínguez-Gil, A1
Venkataraman, V1
Kennedy, D1
McLean, MJ1
Faught, RE1
Magnus-Miller, L1
Bernstein, P1
Rose-Legatt, A1
Schenk, M1
Sick, C1
Holm, E1
Heubner, C1
Weiss, A1
König, I1
Hehlmann, R1
Morresi, S3
de Martino, M1
Hirozane, K1
Novak, GP1
Maytal, J1
Alshansky, A1
Eviatar, L1
Sy-Kho, R1
Siddique, Q1
Beenen, LF1
Lindeboom, J1
Heimans, JJ1
Snoek, FJ1
Adèr, HJ1
van Alphen, HA1
Canger, R2
Fumarola, C1
Guidolin, L1
Palmieri, C1
Molteni, F1
Granata, T2
Hassibi, P1
Zamperini, P1
Pardi, G1
Elston, DM1
Dunn, N1
Wilton, L1
Tsutsumi, K3
Ono, S4
Putnam, GP1
O'Quinn, S1
Bolden-Watson, CP1
Davis, RL1
Gutterman, DL1
Fox, AW1
Loiseau, PJ1
Fernández, G1
Matsuo, F2
Mawer, GE1
Khabibova, AO1
Häuser, FM1
Lukasewitz, P1
Wichert, A1
Lennartz, H1
Paillard, C1
Vanhulle, C1
Devaux, AM1
Ensel, P1
Monroc-Morval, M1
Blanc, T1
Vreugdenhil, M1
Wadman, WJ1
Chappell, KA1
Markowitz, JS1
Jackson, CW1
Hemingway, C1
Leary, M1
Riordan, G1
Schlegal, B1
Walker, K1
Del Río-Garma, M1
Del Río-Garma, MC1
Lojo-Rocamonde, S1
Novo-Rodríguez, I2
Otoom, SA1
Schomburg, U1
Hadeishi, H1
Kawamura, S1
Nonoyama, Y1
Yasui, N1
Miyamoto, T1
Miyamoto, M1
Hirata, K1
Katayama, S1
Jannuzzi, G1
Cian, P1
Thomson, MA1
Lynch, S1
Strong, R1
Shepherd, RW1
Marsh, W1
Meyer, MA1
Jović, NJ1
Mirković, D1
Majkić-Singh, N1
Gara, L1
Roberts, W1
Balen, AH2
Toczko, A1
Mojs, E1
Gueye, L1
Sene, MC1
Sene, F1
Mesdjian, E3
Farnarier, G1
Diagne, M1
Ndiaye, IP1
Fiedler, M1
Piontek, CM1
Wisner, KL1
Ulutin, T1
Gopaul, SV1
Moore, SJ2
Turnpenny, P1
Quinn, A1
Glover, S1
Lloyd, DJ1
Montgomery, T1
Dean, JC3
Faradji, H1
Rousset, C1
Debilly, G1
Cespuglio, R1
Parra, J1
Fernández-Torre, JL1
Chávez, B1
Vilaseca, MA1
Artuch, R1
Clough, HE1
Datta, AN1
Eirís, J1
Del Río, M1
Meseguer, P1
Kelly, DA1
Kayihan, N1
Nennesmo, I1
Ericzon, BG1
Németh, A1
Takajo, I1
Ohi, T1
Shiomi, K1
Sugimoto, S1
Matsukura, S1
Raza, M1
al-Shabanah, OA1
al-Bekairi, AM1
Qureshi, S1
Jarre, A1
Klingmüller, D1
Reddy, DS2
Rogawski, MA2
Droulers, A1
Bodak, N1
Oudjhani, M1
Lefevre des Noettes, V1
Bodak, A1
Joergensen, A1
Hoseth, E1
Kaad, PH1
Moeller, M1
Holsteen, V1
Rix, M1
Frey, M1
Ueda, Y1
Pascarella, R3
Giuva, T1
Fairgrieve, SD1
Jackson, M1
Jonas, P1
Walshaw, D1
Montgomery, TL1
Burn, J1
Lynch, SA1
Margineanu, DG1
Klitgaard, H1
Rutecki, PR1
Shaw, R1
Lanning, A1
Hilty, DM1
Rodriguez, GD1
Hales, RE1
Demircioğlu, S1
Soylu, A1
Pedrera, JD1
Canal, ML1
Carvajal, J1
Postigo, S1
Villa, LF1
Hernández, ER1
Rico, H1
Kudoh, A1
Matsuki, A1
Jozwiak, S1
Terczynski, A1
Nagatomo, I1
Akasaki, Y1
Tominaga, M1
Hashiguchi, W1
Takigawa, M1
Aberg, LE1
Bäckman, M1
Kirveskari, E1
Santavuori, P1
Akman, CI1
Schubert, R1
Matera, V1
Cutarella, R2
Scism, JL1
Powers, KM1
Artru, AA1
Lewis, L1
Dumoulin, L1
Landry, P1
Glauser, TA1
Ronen, GM2
Richards, JE1
Cunningham, C1
Secord, M1
Rosenbloom, D1
Lam, E1
Westley, IS1
Nakajima, M1
Yamato, S1
Shimada, K1
Kitagawa, S1
Honda, A1
Miyamoto, J1
Shoda, J1
Ohya, M1
Miyazaki, H1
Yoon, Y1
Jagoda, A1
Mirza, W1
Montouris, G1
Barrett, PS1
Klostermann, F1
Nolte, G1
Curio, G1
Kozma, C1
Knudsen, FU1
Tonnelier, JM1
Mocquard, Y1
Broch, C1
Vandhuick, O1
Goas, P1
Goas, JY1
Soares, JC1
Chi Chow, J1
Lee, I1
Williams, G1
King, J1
Cunningham, M1
Stephan, M1
Kerr, B1
Hersh, JH1
Säger, J1
Harvey, EA1
Coull, BA1
Huntington, KB1
Khoshbin, S1
Hayes, AM1
Ryan, LM1
Bourg, V1
Lebrun, C1
Chichmanian, RM1
Thomas, P1
Frenay, M1
Hokazono, T1
Satou, M1
Yildizaş, D1
Anarat, A1
Burgut, HR1
Minkova, GD1
Getova, DP1
Sobaniec-Łotowska, M1
Sołowiej, E1
Sobaniec, H1
Artemowicz, B1
Nilsson, L1
Bergman, U1
Diwan, V1
Farahmand, BY1
Persson, PG1
Calvani, M1
Guaitolini, C1
Parisi, G1
Paolone, G1
Aynaci, FM1
Gedik, Y1
Mercho, S1
Lopes-Cendes, I1
Seni, MH1
Benjamin, A1
Dubeau, F1
Andermann, F2
Andermann, E1
Eberle, A1
Salas-Puig, X1
Schachter, SC1
Guye, M1
Gastaut, JL1
Chauvel, P1
Dravet, C3
Finsterer, J1
Pelzl, G1
Hess, B1
Valentino, R1
Di Carlo, C1
Striano, S1
Nappi, C1
Hall, JE1
Burdick, KE1
Langendorf, F1
Repo-Outakoski, M1
Kondo, I1
Ishida, S1
Motooka, H1
Takayama, K1
Maeda, H1
Satoh, K1
Shapiro, D1
Dominiczak, M1
Thapar, A1
Roland, M1
Russell, I1
Roberts, C1
Porter, E1
Wall, S1
van Parys, J1
Harbo, HF1
Dale, PO1
Fauser, BC1
Guo, CY1
Atkinson, SA1
dos Santos, ML1
Hernández-Fustes, OJ1
Lajeunie, E1
Barcik, U1
Thorne, JA1
El Ghouzzi, V1
Bourgeois, M1
Renier, D1
Hall, W1
Chappell, V1
Collings, J1
Stewart, A1
Rieger-Wettengl, G1
Tutlewski, B1
Stabrey, A1
Rauch, F1
Herkenrath, P1
Schauseil-Zipf, U1
Schoenau, E1
Schulpis, KH1
Karikas, GA1
Tjamouranis, J1
Regoutas, S1
Tsakiris, S1
Sodhi, P1
Poddar, B1
Parmar, V1
Kushlinskiĭ, NE1
Vasey, M1
Pomilio, MP1
Daxenbichler, G1
DeVivo, DC1
Blüml, S1
Moreno-Torres, A1
Shic, F1
Nguy, CH1
Ross, BD1
Tishchenkova, IF1
Yilmaz, E1
Doşan, Y1
Gürgöze, MK1
van Lier, HJ1
Arends, J1
Bootsma, HP1
Diepman, L1
Hulsman, J1
Lambrechts, D1
Leenen, L1
Majoie, M1
Schellekens, A1
de Vocht, J1
Hurkacz, M1
Wiela-Hojeńska, A1
Orzechowska-Juzwenko, K1
Kozik, A1
Unolt, J1
Kavakli, K1
Rudenko, AIu1
Konoplianko, TV1
Stetsiuk, RA1
Lee, JK1
Grosse, P1
Rüsch, L1
Tsukahara, H1
Kimura, K1
Todoroki, Y1
Ohshima, Y1
Hiraoka, M1
Shigematsu, Y1
Tsukahara, Y1
Miura, M1
Mayumi, M1
Jung, P1
Doussard-Lefaucheux, S1
Glover, SJ1
Quinn, AG1
Barter, P1
Hart, J1
Turnpenny, PD1
Laskowska, M1
Leszczyńska-Gorzelak, B1
Oleszczuk, J1
Gunal, DI1
Guleryuz, M1
Bingol, CA1
Avoni, P1
Bello-Ramírez, AM1
Carreón-Garabito, BY1
Nava-Ocampo, AA1
Clough, H1
Bertoldo, M1
Tokinaga, N1
Yabe, H1
Hirano, T3
Ozkul, Y1
Gurler, B1
Uckardes, A1
Bozlar, S1
Vainstein, G1
Korzets, Z1
Pomeranz, A1
Gadot, N1
Bohlen, N1
Hertl, M1
Tassinari, CA1
Buchthal, A1
Herrick, CE2
Scott, DF2
Lloyd, MH1
France, M1
Hamilton, C1
Cohne, RD1
Finkel, MJ1
Hari, R1
Lehtovaara, R1
Majuri, H1
Jaeken, J2
Corbeel, L1
Casaer, P1
Carchon, H1
Eggermont, E2
Eeckels, R1
Raworth, RE1
Birchall, G1
Knöpfle, G1
Hutchinson, RM1
Clay, CM1
Simpson, MR1
Wood, JK1
Lewis, JR1
Lagenstein, I2
Sternowsky, HJ2
Blaschke, E1
Rothe, M1
Fehr, R2
Briant, RH1
Foote, SE1
Wallis, WE1
Crawford, LE1
Kogeorgos, J1
Henson, RA1
Harris, AB1
Lockard, JS1
Cumming, WJ1
Livingstone, I1
Cartlidge, NE1
Hartikainen-Sorri, AL1
Kääpä, P1
Saukkonen, AL2
Donnan, GA1
Qu, ZP1
Friel, PN1
Leal, KW1
Wilensky, AJ1
Schulz, HU3
Livingston, S2
Pruce, I2
Pauli, LL2
Poser, W1
Poser, S1
Ritter, G1
Sauer, W2
Ancamp, AK1
Joubert, PH2
Brett, E1
Trompetter-van Woerden, ML1
van der Zwan, A2
Wulff, K5
Würtz-Jørgensen, A4
Rasmussen, KE4
Sommerbeck, KW4
Løhren, V2
Theilgaard, A2
Würtz-Jorgensen, A1
Lohren, V2
Massimo, L1
Pasino, M1
Rosanda Vadalá, C1
Tonini, GP1
Perutelli, P1
Saccomani, L1
Imbeck, H1
Reith, H1
Jacobs, R1
Gabriel, KH1
Bordo, B1
Bossi, L1
Castelli, D1
Gerna, M1
Tognoni, G1
Zagnoni, P1
Aucamp, AK1
Potgieter, GM1
Verster, F1
Gallassi, R3
De Bernardi, M1
Caravaggi, M1
Calzetti, S3
Visintini, D3
Lines, DR1
Vassella, F1
Rüdeberg, A1
Da Silva, V1
Pavlincova, E1
Williamson, PD1
Novelly, RA1
Crema, A1
Austin, WH1
Thorne, HE1
Anthony, M5
Hinterberger, H1
Lance, JW5
Conomy, JP1
Jugenheimer, K1
Eichelbaum, M1
Hildebrandt, WK1
Lhermitte, F1
Marteau, R1
Serdaru, M1
Brown, LW1
Nowack, WJ1
Englander, RN1
Hanna, GR1
Kramer, II1
Suchy, FJ1
Balistreri, WF1
Buchino, JJ1
Sondheimer, JM1
Bates, SR1
Stull, JD1
Bove, KE1
Alexander, FW1
Robinson, R1
von Voss, H1
Schulte-Berbühl, R1
Göbel, U1
Newmark, ME1
Ogunmekan, AO1
Svatý, J1
Andersen, B2
Lombardi, M1
Cattaino, G1
Boutillier, L1
de Lumley, L1
Saura, R1
Boulesteix, J1
Rosenberry, KR1
Korberly, BH1
Graziani, LJ1
Sussman, NM1
McLain, LW1
Gerber, N1
Harland, RC1
Lynn, RK1
Houghton, LD1
Antonias, JI1
Schimschock, JC1
Oxley, J1
Huhtaniemi, I1
Mihaly, GW2
Miles, JL2
Morris, PM1
Ruuskanen, I1
Kilpeläinen, HO1
Riekkinen, PJ1
Louis, WJ1
Varma, R1
Hoshino, AY1
Dahlqvist, R1
Borgå, O1
Rane, A2
Walsh, Z1
Sjöqvist, F1
Pinder, RM1
Brogden, RN1
Speight, TM1
Avery, GS1
Clark, JE1
Blaschke-Zimmermann, E1
Iffland, E1
Silberstein, P1
Wada, JA1
Otsuki, S1
Luders, H1
Pippenger, C1
Brachet, A2
Henry, P2
Girard, PL1
Papy, JJ1
Dumas, M2
Barnes, SE2
Bland, D1
Cole, AP1
Evans, AR1
Gabreëls, FJ1
Sutor, AH1
Jesdinsky-Buscher, C1
Osuntokun, BO1
Simon, D1
Haigh, D1
Forsythe, WI1
Groh, Ch1
Rosenmayr, FW1
Hassan, MN1
Laljee, HC1
Parsonage, MJ1
Ronthal, M2
Terespolsky, PS1
Malek, F1
Mamoli, B1
Pateisky, K1
Bower, BD1
Stolzis, L1
Scheffner, D3
Coulthard, MG1
Gädeke, R1
Sonnen, AE1
Zelvelder, WH1
Bruens, JH1
Stanková, L1
Manford, M1
Brätter, P1
Brunetto, R1
Gramm, HJ1
Recknagel, S1
Bittencourt, PR4
Mader, MJ1
Bigarella, MM1
Dóro, MP1
Gorz, AM2
Marcourakis, TM1
Ferreira, ZS1
Chandra, B1
Concas, A1
Serra, M1
Sanna, E1
Pepitoni, S1
Mascia, MP1
Biggio, G1
Percy-Robb, I1
Almuna, R1
Tohá, D1
Campos, G1
del Río, S1
Taneja, N1
Kucheria, K1
Jain, S1
Tandon, JK1
Hiramatsu, M1
Kinno, I1
Kanakura, K1
Sato, K1
Mori, A2
Bernardi, G1
Monza, G1
Tisdale, JE1
Tsuyuki, RT1
Oles, KS1
Omtzigt, JG3
Los, FJ2
Pijpers, L2
Imaizumi, T1
Izumi, T1
Fukuyama, Y2
Churchyard, A1
Khangure, M1
Grainger, K1
Stores, G1
Williams, PL1
Styles, E1
Zaiwalla, Z1
Sakemi, K1
Hayasaka, K2
Tahara, M1
Sanada, Y1
Takada, G1
Valdizán, EM1
Dodrill, CB1
Fenwick, PB1
Morreale, A2
Di Sarro, R1
Marra, M1
Lugaresi, E2
Pieters, MS1
Bakker, AM1
van Geel, AA1
Stijnen, T1
Jennekens-Schinkel, A1
Lanser, JB1
Rajantie, J1
Kajosaari, M1
Ylitalo, V1
Jha, S1
Nag, D1
Shukla, R1
Kar, AM1
Saxena, RC1
Trivedi, JK1
Sennoune, S1
Bonneton, J1
Ohtani, K1
Tagawa, T1
Niki, Y1
Kriel, RL2
Jones-Saete, CM1
Ong, BY1
Jancik, JT1
Hönack, D1
Cornel, MC1
Grobbee, DE1
Jahoda, MG1
Brandenburg, H1
Stewart, PA1
Gaillard, HL1
Sachs, ES1
Wladimiroff, JW1
Leavitt, A1
Erickson, DM1
McCormick, KB1
Loewenson, RB1
Sells, CJ1
Benedetti, TJ1
Julian, C1
Legras, C1
Magaudda, A1
Soulayrol, S1
Giraud, N1
Trentin, G1
Lenn, NJ1
Robertson, M1
Pezzilli, R1
Billi, P1
Melandri, R1
Broccoli, PL1
Durrheim, DN1
Joubert, J1
Griesel, RD1
Kayemba Kay's Kabangu, S1
Bovier Lapierre, M1
Jalaguier, E1
Kaya, IS1
Dilmen, U1
Toppare, M1
Senses, DA1
Prentice, HG1
Declerck, AC3
Wauquier, A2
Mergen, F1
Lambert, DM1
Goncalves Saraiva, JC1
Poupaert, JH1
Dumont, P1
Abed, WT1
Shiraga, H1
Watanabe, Y1
Sunaoshi, W2
Takanashi, S1
Shirai, H2
Hosoda, N1
Parietti, L1
Baasch, H1
Caresia, L1
Mück, W1
Barzaghi, N1
Tokatli, A1
Coşkun, T1
Cataltepe, S1
Ozalp, I1
Brignolio, F1
Baruchello, M1
Varagić, V1
Gómez-Cárdenas, E1
Guerrero, M1
Segura-Pastor, D1
Gil-Salú, JL1
Matsui, K1
Iwamoto, H1
Ohtsuki, N1
Kobayashi, T1
Miyake, S2
Yamada, M1
Kiker, M1
Orrell, RW1
Forsythe, I1
Butler, R1
McGuire, R1
Yan, CS1
Ring, HA1
Heller, AJ1
Marshall, WJ1
Opala, G1
Winter, S1
Vance, C1
Vance, H1
Hutchison, HT1
Linn, LS1
Tanaka, H1
Izumi, M1
Okada, H1
Ishikawa, S1
Reisser, C1
Maier, H1
Jones, TH1
Silver, JM1
Shin, C1
McNamara, JO1
Thom, H1
Carter, PE1
Cole, GF1
Stevenson, KL1
Herngren, L2
O'Donohoe, NV1
Giardina, M1
Sideri, G1
Dreier, JP1
Mikati, M1
Triggs, WJ1
Post, RM1
Altshuler, LL1
Ketter, TA1
Denicoff, K1
Weiss, SR1
Shapira, Y1
Binek, J1
Hany, A1
Egloff, B1
Heer, M1
Lenti, C1
Masserini, C1
Peruzzi, C1
Guareschi Cazzullo, A1
Nothbaum, N1
Anai, T1
Hirota, Y1
Oga, M1
Yoshimatsu, J1
Miyakawa, I1
Calandre, EP2
Rodriquez-Lopez, C1
Blazquez, A1
Cano, D1
Abadín, JA1
Durán, JA1
Sánchez, A1
Serrano, JS1
Galli, G1
Hebestreit, H1
Pannenbecker, J1
Mingers, AM1
Bartels, H1
Rodrigo-Saez, E1
Camiña, MF1
Hu, LJ2
Lu, XF2
Lu, BQ2
Huang, YQ2
Kerner, J2
Acsádi, G2
Lakatos, J1
Sándor, A1
Tempelhoff, R1
Modica, PA1
Spitznagel, EL1
van Wieringen, A1
van Emde Boas, W1
Vermeij, TA1
Miller, JW1
Ferrendelli, JA1
Lorusso, S1
Procaccianti, G2
Wiedemann, G1
Haupt, M1
Rommel, A1
Rommel, KF1
Biesenbach, R1
Schmidt, W1
Clancy, RR2
Sälke-Treumann, A1
Boenigk, HE1
McManus, DQ1
Guterman, A1
Briggle, TV1
Vazquez, D1
Perchalski, R1
Yost, RA1
Wong, P1
Robbins, DK1
Wedlund, PJ1
Kuhn, R1
Chang, SL1
Mehrotra, TN1
Aneja, GK1
Arora, V1
Goel, S1
Singh, VS1
Iivanainen, M1
Waltimo, O1
Tokola, O1
Parantainen, J1
Tamminen, M1
Allonen, H1
Sakane, Y1
Shuto, H1
Hatanaka, T1
Foley, H1
Squier, W1
Hope, PL1
Lindenbaum, RH1
Sauer, I1
Staemmler, U1
Jones, GL1
Baringer, JR1
Reichert, WH1
Dominguez-Granados, R1
Gomez-Rubio, M1
Molina-Font, JA1
Koide, N1
Abe, M1
Ristanović, D1
Dokić-Ristanović, D1
Jovanović, V1
Cosgrove, M1
Pople, S1
Miyauchi, T1
Endo, K1
Hagimoto, H1
Tanaka, K4
Ishii, M1
Bun, H1
Monjanel-Mouterde, S1
Noel, F1
Durand, A1
Cano, JP1
Schnabel, R1
Villagrán, R1
Furuya, M1
Hashimoto, K1
Kamayachi, S1
Fujino, O1
Ruser, I1
Kubota, T1
Yamaguchi, N1
Williams, N1
Wiedmann, KD1
Christmann, D1
Mutschler, V1
Colombo, JP1
Bureau, M1
Giovanardi-Rossi, P1
Garzón, P1
González-Cornejo, S1
Román-Maldonado, S1
Park, DM1
Smith, AT1
Jimenez-Rodriguezvila, M1
Caro-Patón, A1
Conde, M1
Dueñas-Laita, A1
Martin-Lorente, JL1
Fernandez Perez de Villalain, MJ1
Gonzalez Martinez de Zarate, JL1
Marañon, A1
Hamon, B2
Mervaala, E1
Tiihonen, P1
Riekkinen, P1
Giroud, M3
Dumas, R2
Robinek, F1
Czeizel, E1
Puche, E2
Garcia de la Serrana, H2
Mota, C2
Saucedo, R1
Haddad, J1
Willard, D1
Dunstan, PR1
Zielinski, JJ3
Luss, K1
Koerner, M1
Yerby, M1
Friel, P1
McCormick, K1
Mikkelsen, M1
Haust, HL1
Poon, HC1
Carson, R1
VanDeWetering, C1
Peter, F1
Wietholtz, H1
Zysset, T1
Kreiten, K1
Kohl, D1
Büchsel, R1
Matern, S1
Lorz, U1
Glötzner, FL1
Macphee, GJ2
Beastall, GH1
Couillault, G1
Gouyon, JB1
Dauvergne, M1
Fantino, M1
Nivelon, JL1
Fischman, MA1
Hull, D1
Bartus, SA1
Schweizer, RT1
Guberman, A1
Hipola, D1
Chevallier, B1
Nègre, V1
Bidat, E1
Lagardère, B1
Oakeshott, P1
Murthy, VS1
Armijo Simón, JA1
Arteaga Manjón-Cabeza, R1
Garcia Morillas, M1
Hara, H1
Rudziński, P1
Jankowicz, E1
Sobaniec-Lotowska, M1
Konnerth, A1
Yaari, Y1
Rasmussen, KT1
Carstensen, H1
Invitti, C1
Danesi, L1
Dubini, A1
Cavagnini, F1
Cutler, MG1
Horton, RW1
Pacifici, GM1
Bertilsson, L1
Dockweiler, U1
Legius, E1
Marks, WA1
Morris, MP1
Grunow, JE1
Bobele, GB1
Hille, MR1
Tuggle, D1
Snead, OC2
Komatsu, M3
Kodama, S3
Konishi, H2
Momota, K1
Wada, H1
Escousse, A1
Rodat, O1
Nicolas, G1
Anger, JP1
Develay-Legueut, MA1
Michaux, P1
Lloyd, KG1
Weinbaum, PJ1
Cassidy, SB1
Vintzileos, AM1
Campbell, WA1
Ciarleglio, L1
Nochimson, DJ1
Olmos-Garcia de Alba, G1
Valdez, JM1
Duncan, J1
Cornford, EM1
Oldendorf, WH1
Steru, D1
Perret, A1
Miyao, M1
Sawa, R1
Shimoizumi, H1
Kamoshita, S1
Deichl, A1
Hartmann, AM1
Steldinger, R1
Brown, EG2
Koch, RD1
Tzenow, H1
Ninomiya, N1
Paule, MG1
Killam, EK1
Laub, MC1
Streete, JM1
Pettit, LI1
Newbery, JE1
Goggin, T4
Casey, C1
Ettlin, T1
Gough, H2
Bissessar, A2
Baker, M2
Crowley, M2
Vaĭntrub, MIa1
Arimoto, K2
Sakuragawa, N2
Suehiro, M2
Watanabe, H2
Shi, FL1
Lerman-Sagie, T1
Statter, M1
Szabo, G1
Lerman, P1
Sadahiro, N2
Larrieu, JL1
Lagueny, A1
Ferrer, X1
Julien, J1
Pakalnis, A1
Drake, ME2
John, K2
Kellum, JB1
Lichten, EM1
Messori, A1
Faingold, CL1
Browning, RA1
Hillebrand, G1
Castro, LA1
van Scheidt, W1
Beukelmann, D1
Land, W1
Silvado, CE1
Gates, JR1
Mireles, RE1
Garcia de Alba, GO1
Malagon Valdez, J1
Franco Delgadillo, J1
Ramos Peek, J1
Yamamoto, M1
Ludwig, U1
Daute, KH1
van Egmond, H1
Degomme, P1
de Simpel, H1
Dierick, AM1
Roels, H1
Bertollini, R2
Mastroiacovo, P2
Lammer, EJ1
Sever, LE1
Oakley, GP1
Kuchar, M1
Smísek, M1
Cigánek, L1
Volmut, J1
Issakainen, J1
Matsuda, Y1
Imai, Y1
Trimble, R1
Ishikawa, T2
Ogino, C1
Furuyama, M1
Kanayama, M2
Awaya, A1
Yamaguchi, A1
Foussard-Blanpin, O1
Prieur, D1
Huot, C1
Gauthier, M1
Lebel, M1
Larbrisseau, A1
Curran, MA1
Rosman, NP1
Chapman, AG1
Premachandra, M1
Spiel, G2
Feucht, M2
Amemiya, F1
Kimura, S1
Honda, K1
Ideno, R1
Blajev, B1
de la Cruz, N1
Egli, M1
Geudelin, B1
Kaspar, U1
Ketz, E1
Kronauer, C1
Kispál, G1
Dani, M1
Garrett, A1
Kanazawa, O1
Sengoku, A1
Kawai, I1
Neef, C1
de Voogd-van der Straaten, I1
Connacher, AA1
Borsey, DQ1
Browning, MC1
Jung, RT1
Bury, RW2
Fullinfaw, RO2
Armour, DJ1
Veitch, GB1
McGuire, GM1
Thompson, GG1
Moore, MR1
Sharma, SK1
Selvamurthy, W1
Singh, TP1
Ilyés, I1
Princzinger, A1
Sári, B1
György, I1
Onoe, S1
Mimaki, T1
Seino, Y1
Yabuuchi, H1
Yamashita, G1
Yuen, WC1
Whiteoak, R1
Thompson, RP1
Tsuru, N1
Maeda, T1
Tsuruoka, M1
Fischer, JH2
Barr, AN1
Paloucek, FP1
Dorociak, JV1
Spunt, AL1
Frohn, C1
Hicks, RA1
Murphy, JV2
Jackson, MA1
Krall, RL1
Resor, SJ1
Narisawa, K1
Tada, K1
Hori, K1
Rangel, RJ1
Chitayat, D1
Anderson, L1
Hall, JG1
Miles, MV1
Thorn, MD1
Damasceno, BP1
Campos Junior, Sda S1
Martins, LF1
de Melo-Souza, SE1
MacGregor, DL1
Howel, D1
Iriki, T1
Shirai, Y1
Naitoh, H1
Ambrosetto, G1
Zäh, W1
Rengeling, M1
Rühl, G1
Hackenberg, K1
Dailey, JW1
Jobe, PC1
Seymour, RA1
Smith, DG1
Turnbull, DN1
Lisk, DR1
Greene, SH1
Cornaggia, C1
Giuccioli, D1
Pinelli, P1
Pruneri, C1
Cathro, DM1
Hardman, RP1
Benninger, C1
Matthis, P1
Burgess, RJ1
Paulson, GW1
Nishioka, R1
Takeuchi, M1
Kawai, S1
Nakamura, M1
Kondo, K1
Dieterich, E1
Baier, WK1
Doose, H1
Tuxhorn, I1
Martens, WL1
Koivikko, M1
John, G1
Zhou, SS1
Frey, HH1
Matsui, T1
Oei, LT1
Arnoldussen, W1
te Dorsthorst, M1
Morishita, H1
Wada, Y1
Chan, K1
Teoh, R1
Lok, S1
Segni, G1
Lewis, JH1
Nolte, JL1
Westwood, AP1
Bassett, ML1
Searle, J1
de Pasquet, EG1
Gomensoro, JB1
de Bustos, LF1
Tenzer, SM1
Tomlinson, EB1

Clinical Trials (35)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Phase 2, Double-blind, Randomized, Placebo-controlled Pharmacokinetic Trial in 2 Parallel Groups to Investigate Possible Drug-drug Interactions Between Stiripentol or Valproate and GWP42003-P in Patients With Epilepsy[NCT02607891]Phase 235 participants (Actual)Interventional2016-11-09Completed
PSG in Valproate-induced Nocturnal Enuresis in Children[NCT04191863]260 participants (Actual)Observational2018-09-01Completed
Exploration of Genotype Based Personalized Prescription of Valproate Sodium in Anti-epileptic Treatment[NCT01172626]150 participants (Anticipated)Observational2010-08-31Not yet recruiting
The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy[NCT05450822]550 participants (Anticipated)Observational2022-02-18Recruiting
A Therapeutic Confirmatory, Open-label, Multi-center, Randomized 2 Parallel Groups, Community-based Trial Studying the Efficacy and Safety of Levetiracetam (1000 to 3000 mg/Day Oral Tablets 250-500 mg b.i.d.) Compared to Sodium Valproate (1000 to 2000 mg/[NCT00175903]Phase 31,701 participants (Actual)Interventional2005-02-28Completed
Comparative Study of Dietary and Immunological Management of Refractory Epilepsy in Children Attending Assiut Pediatric University Hospital[NCT04542629]Phase 4140 participants (Anticipated)Interventional2020-10-01Not yet recruiting
EEG Objectification in Neuropsychiatry[NCT01476228]100 participants (Anticipated)Interventional2011-11-30Not yet recruiting
Evaluation of Valproic Acid (VPA) as Adjunctive Therapy for Liver Transplant Patients With Moderate to Severe Hemorrhage at Risk of Ischemia Reperfusion (I/R) Injury[NCT04531592]Phase 20 participants (Actual)Interventional2022-01-31Withdrawn (stopped due to Study terminated by the Sponsor)
Phase I Study of Cytolytic Viral Activation Therapy (CVAT) for Recurrent/Metastatic Nasopharyngeal Carcinoma[NCT02761291]Phase 118 participants (Anticipated)Interventional2016-05-31Recruiting
Evaluation of Valproic Acid (VPA) as Adjunctive Therapy for Trauma Patients With Moderate to Severe Hemorrhage at Risk of Ischemia Reperfusion (I/R) Injury[NCT04531579]Phase 20 participants (Actual)Interventional2022-01-31Withdrawn (stopped due to Study terminated by the Sponsor.)
Effect of Iron Status on Occurrence of Non-transferrin-bound Iron (NTBI) in Serum in Response to an Oral Iron Load[NCT02831712]50 participants (Anticipated)Interventional2013-04-30Active, not recruiting
A Clinical Pharmacokinetics Comparing Brand and Generic Topiramate in Epilepsy Patients : A Open-label,Randomised, Three-period Crossover Study[NCT02113787]24 participants (Actual)Interventional2014-02-28Completed
Pilot Study of Seizure Prophylaxis With Levetiracetam in Aneurysmal Subarachnoid Hemorrhage[NCT01935908]Phase 40 participants (Actual)Interventional2013-05-31Withdrawn (stopped due to no funding)
Levetiracetam, Carbamazepine and Lamotrigine and Hormonal Side Effects in Adult Males and Females.[NCT00460070]240 participants (Actual)Observational2007-01-31Completed
Effects and Consequences for Mother and Child From Treatment for Depression, A Prospective Randomized, Placebo- Controlled, Trial With Internet-based Cognitive Behavior Therapy and Sertraline or Placebo for Moderate Depression in Pregnancy[NCT02185547]Phase 417 participants (Actual)Interventional2016-02-21Terminated (stopped due to Difficulties in recruiting participants.)
TOPAMAX (Topiramate) Monotherapy Comparison Trial to Standard Monotherapy in the Treatment of Newly Diagnosed Epilepsy (RWJ-17021-000); Phase IIIB[NCT00236717]Phase 3865 participants (Actual)Interventional1997-09-30Completed
Effect of Melatonin on Seizure Outcome, Neuronal Damage and Quality of Life in Patients With Generalized Epilepsy: A Randomized, add-on Placebo-controlled Clinical Trial[NCT03590197]Phase 4104 participants (Actual)Interventional2018-08-06Completed
Evaluation d'un Dispositif de Suivi téléphonique Sur la Qualité de Vie Dans Les Crises Psychogènes Non Epileptiques.[NCT02311829]136 participants (Anticipated)Interventional2014-01-31Recruiting
A Pilot Study of Prophylactic Management of Lamotrigine for Bipolar Disorder in Pregnant Women[NCT03774641]20 participants (Anticipated)Observational2018-12-03Recruiting
Effect of the Treatment of Vitamin D Deficiency in Drug-resistant Epilepsy[NCT03475225]Phase 3400 participants (Anticipated)Interventional2018-04-30Not yet recruiting
A Multicenter, Open-Label Conversion of Valproate Monotherapy to Lamotrigine Monotherapy in Patients With Epilepsy[NCT00043914]Phase 472 participants Interventional2002-01-14Completed
A Phase II Multiple Site, Randomized, Placebo-Controlled Trial of Oral Valproic Acid for Autosomal Dominant Retinitis Pigmentosa[NCT01233609]Phase 290 participants (Actual)Interventional2010-11-30Completed
A Study of Divalproex Sodium in Children With Autism Spectrum Disorder and Epileptiform EEG[NCT01170325]Phase 20 participants (Actual)Interventional2010-06-30Withdrawn
Bioequivalence Study of Sodium Valproate and Valproic Acid Extended Release Tablets in Healthy Human Volunteers[NCT05641649]Phase 416 participants (Anticipated)Interventional2023-08-06Active, not recruiting
Efficacy, Tolerability and Adherence of the Modified Atkins Diet on Drug-resistant Epilepsy in Adults Patients[NCT03183076]14 participants (Actual)Interventional2015-09-01Completed
Effect of Adding Lamotrigine to Sodium Valproate in Childhood Epilepsy: Clinicolabratory Study[NCT05881928]Phase 450 participants (Anticipated)Interventional2023-07-25Not yet recruiting
Estudio clínico Fase III Para Evaluar la Eficacia terapéutica en Pacientes Mexicanos Con Dislipidemia Mediante el Uso vía Oral de L-Carnitina + Atorvastatina Comparado Con Atorvastatina[NCT03696940]Phase 3120 participants (Actual)Interventional2018-05-28Active, not recruiting
A Prospective Study on Long-term Outcome and Potential Usefulness fo an Intervention Aimed at Reducing Adverse Effects in Patients With Refractory Epilepsy[NCT03939507]1,000 participants (Actual)Interventional2006-11-06Completed
Reducing Cardiovascular Risk in Adults With Serious Mental Illness Using an Electronic Medical Record-based Clinical Decision Support[NCT02451670]10,347 participants (Actual)Interventional2016-01-20Completed
Evaluating the Impact of Supplementing Residential Substance Use Treatment With Written Exposure Therapy for Veterans With Co-Occurring PTSD and Substance Use Disorders[NCT05536908]50 participants (Anticipated)Interventional2023-06-22Recruiting
Combined Scalp and Ear Acupuncture in Patients With Proton Pump Inhibitor- Dependent Gastroesophageal Reflux Disease[NCT04660019]43 participants (Actual)Interventional2020-08-10Completed
In Vivo Study of Safety, Tolerability and Dosing Effect on SMN mRNA and Protein Levels of Valproic Acid in Patients With Spinal Muscular Atrophy[NCT00374075]Phase 142 participants Interventional2003-09-30Completed
Phase I/II Trial of Valproic Acid and Carnitine in Infants With Spinal Muscular Atrophy Type I (CARNI-VAL Type I)[NCT00661453]Phase 1/Phase 240 participants (Actual)Interventional2008-04-30Completed
Multi-center Phase II Trial of Valproic Acid and Carnitine in Patients With Spinal Muscular Atrophy (SMA CARNI-VAL Trial)[NCT00227266]Phase 294 participants (Actual)Interventional2005-09-30Completed
Valproic Acid-associated Hypoalbuminemia in Medically Fragile Pediatric and Young Adult Patients in a Long Term Care Facility Part 1: Potential Mechanism for Decreased Albumin Synthesis[NCT00723762]90 participants (Anticipated)Observational2009-02-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Mean Change From Baseline in Best Corrected Visual Acuity

Mean change in best corrected visual acuity as assessed by ETDRS (Early Treatment Diabetic Retinopathy Study) method from baseline to week 52 (NCT01233609)
Timeframe: baseline to week 52

Interventionletters read correctly (Mean)
Valproic Acid -- Right Eye-1.4
Valproic Acid--Left Eye0.0
Placebo --Right Eye0.2
Placebo --Left Eye1.3

Mean Change in Visual Field Area From Baseline to 52 Weeks--I4e Isopter

Mean change in visual field area from baseline to 52 weeks. Visual field area is measured with semi-automated kinetic perimetry (SKP) using the Octopus 900 (Haag-Streit) with the I4e target size for each eye and done at least twice to ensure reliable sessions; the visual field area measurements are averaged over the two sessions. Analysis performed with linear mixed model (NCT01233609)
Timeframe: baseline to week 52

InterventionVisual field area (degrees squared) (Mean)
Placebo--Right Eye80.9
Placebo--Left Eye115.7
Valproic Acid--Right Eye5.3
Valproic Acid--Left Eye19.5

Mean Change in Visual Field Area From Baseline to 52 Weeks--III4e Isopter

Mean change in visual field area from baseline to 52 weeks. Visual field area is measured with semi-automated kinetic perimetry (SKP) using the Octopus 900 (Haag-Streit) with the III4e target size for each eye and done at least twice to ensure reliable sessions; the visual field area measurements are averaged over the two sessions. Analysis performed with linear mixed model (NCT01233609)
Timeframe: baseline to week 52

InterventionVisual field area (degrees squared) (Mean)
Placebo--Right Eye-122.9
Placebo--Left Eye-112.0
Valproic Acid--Right Eye-293.7
Valproic Acid--Left Eye-237.1

Static Perimetry by Treatment Arm--Full Field Hill of Vision

Mean change from baseline at week 52 for Full field Hill of Vision (Static perimetry) (NCT01233609)
Timeframe: baseline to week 52

Interventiondb-steridians (Mean)
Placebo--Right Eye-0.3
Placebo--Left Eye-1.4
Valproic Acid--Right Eye-0.2
Valproic Acid--Left Eye-0.6

Static Perimetry Volume--30 Degree Hill of Vision

Mean Change from baseline to week 52 for Static Perimetry Volume --30 Degree Hill of Vision. Full field static perimetry protocol was followed using the Octopus 900 (Haag-Streit) for a single session for each eye. (NCT01233609)
Timeframe: baseline to week 52

Interventiondb-steridans (Mean)
Placebo--Right Eye-0.3
Placebo--Left Eye-0.3
Valproic Acid--Right Eye-0.2
Valproic Acid--Left Eye-0.2

Predicted Annual Rate of Change in 10 Year Risk of Fatal or Nonfatal Heart Attack or Stroke

A modifiable risk component for each cardiovascular risk factor not at optimal goal at the time of each encounter was calculated as the difference between total 10-year atherosclerotic cardiovascular disease risk with the patient's actual values and the goal value. Total modifiable cardiovascular risk was calculated by summing the modifiable cardiovascula risk components across cardiovascular risk factors not at optimal goal at the time of the encounter, and was calculated for each enrolled patient at the index visit and each subsequent encounter during the intervention period. Annual rate of change in modifiable cardiovascular risk was estimated from all patient encounters. A comparison of the difference in model-estimated rate of change in modifiable cardiovascular risk at 12 months post-index tested the primary efficacy hypothesis. (NCT02451670)
Timeframe: Index to 12 months post index visit

Interventionpercentage of annual rate of change (Number)
Prioritized Clinical Decision Support14.2
Usual Care20.8

Anthropometric Measures of Nutritional Status (Body Mass Index [BMI] Z-scores, Weight for Length Ratios, Lean/Fat Mass Via DEXA, Growth Parameters, and Triceps Skinfold Measures)

(NCT00661453)
Timeframe: -2 weeks, time 0, 3 months, 6 months

Interventiong (Mean)
Lean Mass BaselineLean Mass 3 monthsLean Mass 6 monthsFat Mass BaselineFat Mass 3 monthsFat Mass 6 months
SMA Type 14317.154993.925133.833011.373618.254316.08

Max CMAP Amplitude (Mean)

The maximum Compound Motor Action Potential (CMAP) is a measurement obtained through EMG testing that is associated with disease progression. In this study, we measure the maximum CMAP by stimulating one nerve in the hand and measuring the response of the muscle. This is done multiple times, the outcome used is the highest peak, or response observed. (NCT00227266)
Timeframe: 1 month prior to official enrollment, beginning of study (0 months), 6 months, 12 months (data point not available)

,,
InterventionmV (Mean)
Baseline6 months
Cohort 1a Sitters Placebo Then Treatment2.282.32
Cohort 1b Sitters Treatment2.932.37
Cohort 2 Standers and Walkers - Treatment5.526.56

Max CMAP Amplitude Median

The maximum Compound Motor Action Potential (CMAP) is a measurement obtained through EMG testing that is associated with disease progression. In this study, we measure the maximum CMAP by stimulating one nerve in the hand and measuring the response of the muscle. This is done multiple times, the outcome used is the highest peak, or response observed. (NCT00227266)
Timeframe: 1 month prior to official enrollment, beginning of study (0 months), 6 months, 12 months (data point not available)

,,
InterventionmV (Median)
Baseline6 months
Cohort 1a Sitters Placebo Then Treatment1.911.44
Cohort 1b Sitters Treatment2.21.8
Cohort 2 Standers and Walkers - Treatment5.35.85

Max CMAP Area (Mean)

The maximum Compound Motor Action Potential (CMAP) area is a measurement obtained through EMG testing that is associated with disease progression. In this study, we measure the maximum CMAP by stimulating one nerve in the hand and measuring the response of the muscle. This procedure is repeated multiple times. The maximum area is the response that results in the largest area under the response curve. (NCT00227266)
Timeframe: 1 month prior to official enrollment, beginning of study (0 months), 6 months, 12 months (data point not available)

,,
InterventionmVms (Mean)
Baseline6 months
Cohort 1a Sitters Placebo Then Treatment5.465.28
Cohort 1b Sitters Treatment5.455.26
Cohort 2 Standers and Walkers - Treatment14.8516.26

Max CMAP Area (Median)

The maximum Compound Motor Action Potential (CMAP) area is a measurement obtained through EMG testing that is associated with disease progression. In this study, we measure the maximum CMAP by stimulating one nerve in the hand and measuring the response of the muscle. This procedure is repeated multiple times. The maximum area is the response that results in the largest area under the response curve. (NCT00227266)
Timeframe: 1 month prior to official enrollment, beginning of study (0 months), 6 months, 12 months (data point not available)

,,
InterventionmVms (Median)
Baseline6 months
Cohort 1a Sitters Placebo Then Treatment3.63.74
Cohort 1b Sitters Treatment4.63.4
Cohort 2 Standers and Walkers - Treatment13.6516.85

Modified Hammersmith Change From Baseline to 6 Months

Comparison of Modified Hammersmith Change from baseline to 6 months. Scores range from 0 to 40. A higher score indicates a better outcome. This scale is used to assess gross motor abilities of non-ambulant children with SMA in multiple research trials as well as in clinical settings. (NCT00227266)
Timeframe: 0 months, 6 months

,
InterventionScore (Mean)
Baseline visit (0 weeks)6 Month visit (V2)Change from Baseline
Cohort 1a Sitters Placebo Then Treatment20.020.60.6
Cohort 1b Sitters Treatment16.616.80.2

Modified Hammersmith Extend Baseline

"Baseline Modified Hammersmith Extend testing. The baseline test is the score they receive during their screening visits. This scale ranges from 0 to 56. A higher score indicates a better outcome.~This scale is used to assess gross motor abilities of children with SMA in multiple research trials as well as in clinical settings." (NCT00227266)
Timeframe: 1 month prior to enrollment, at enrollment (0 months)

InterventionScore (Mean)
Modified Hammersmith Extend at S1 (-4 weeks)Modified Hammersmith Extend at S2 (0 weeks)
Cohort 2 Experimental47.048.3

Reviews

317 reviews available for valproic acid and Aura

ArticleYear
Treatment of valproic acid overdose with meropenem in an epileptic patient.
    The American journal of emergency medicine, 2022, Volume: 53

    Topics: Adult; Anti-Bacterial Agents; Anticonvulsants; Carbapenems; Drug Overdose; Epilepsy; Female; Humans;

2022
Antiseizure medications and thyroid hormone homeostasis: Literature review and practical recommendations.
    Epilepsia, 2022, Volume: 63, Issue:2

    Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Cross-Sectional Studies; Epilepsy; Female; Homeosta

2022
Is the prevalence of thyroid disease higher in children receiving antiepileptic medication? A systematic review and meta-analysis.
    Seizure, 2022, Volume: 94

    Topics: Anticonvulsants; Carbamazepine; Child; Epilepsy; Humans; Levetiracetam; Prevalence; Thyroid Diseases

2022
Combined effects of levetiracetam and sodium valproate on paediatric patients with epilepsy: a systematic review and meta-analysis.
    Seizure, 2022, Volume: 95

    Topics: Anticonvulsants; Child; Epilepsy; Humans; Levetiracetam; Topiramate; Valproic Acid

2022
Insights into Structural Modifications of Valproic Acid and Their Pharmacological Profile.
    Molecules (Basel, Switzerland), 2021, Dec-24, Volume: 27, Issue:1

    Topics: Amides; Animals; Anticonvulsants; Drug Monitoring; Epilepsy; Humans; Molecular Structure; Structure-

2021
The efficacy of lamotrigine after failure of the first administration of valproate in treating epilepsy: a systematic review and meta-analysis.
    Annals of palliative medicine, 2022, Volume: 11, Issue:1

    Topics: Epilepsy; Humans; Lamotrigine; Quality of Life; Triazines; Valproic Acid

2022
Epilepsy in Pregnancy-Management Principles and Focus on Valproate.
    International journal of molecular sciences, 2022, Jan-25, Volume: 23, Issue:3

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Autism

2022
Fanconi Syndrome Secondary to Sodium Valproate Therapy: Experience and Literature Review.
    Pediatric neurology, 2022, Volume: 130

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Fanconi Syndrome; Female; Humans; Ma

2022
Published population pharmacokinetic models of valproic acid in adult patients: a systematic review and external validation in a Chinese sample of inpatients with bipolar disorder.
    Expert review of clinical pharmacology, 2022, Volume: 15, Issue:5

    Topics: Adult; Anticonvulsants; Bayes Theorem; Bipolar Disorder; Child; China; Epilepsy; Humans; Inpatients;

2022
Transcriptome meta-analysis of valproic acid exposure in human embryonic stem cells.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2022, Volume: 60

    Topics: Anticonvulsants; Epilepsy; Female; Human Embryonic Stem Cells; Humans; Pregnancy; Transcriptome; Val

2022
Side effects of long-term oral anti-seizure drugs on thyroid hormones in patients with epilepsy: a systematic review and network meta-analysis.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2022, Volume: 43, Issue:9

    Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Lamotrigine; Levetiracetam; Network Meta-Analysis;

2022
Effect of long-term valproic acid therapy on lipid profiles in paediatric patients with epilepsy: a meta-analysis
    Epileptic disorders : international epilepsy journal with videotape, 2022, 10-01, Volume: 24, Issue:5

    Topics: Child; Cholesterol, HDL; Cholesterol, LDL; Epilepsy; Humans; Lipids; Valproic Acid

2022
Management of epilepsy in brain tumor patients.
    Current opinion in oncology, 2022, 11-01, Volume: 34, Issue:6

    Topics: Anticonvulsants; Benzodiazepines; Brain Neoplasms; Epilepsy; Humans; Isocitrate Dehydrogenase; Lacos

2022
The interplay of epilepsy with impaired mitophagy and autophagy linked dementia (MAD): A review of therapeutic approaches.
    Mitochondrion, 2022, Volume: 66

    Topics: Anticonvulsants; Carbamazepine; Dementia; Epilepsy; Felbamate; Gabapentin; Humans; Inflammasomes; La

2022
Risk factors and outcome of hyperammonaemia in people with epilepsy.
    Journal of neurology, 2022, Volume: 269, Issue:12

    Topics: Adult; Ammonia; Epilepsy; Humans; Hyperammonemia; Observational Studies as Topic; Oxcarbazepine; Ris

2022
Therapeutic approach to neurological manifestations of Angelman syndrome.
    Expert review of clinical pharmacology, 2022, Volume: 15, Issue:7

    Topics: Angelman Syndrome; Anticonvulsants; Epilepsy; Epilepsy, Generalized; Humans; Valproic Acid

2022
Breastfeeding while on treatment with antiseizure medications: a systematic review from the ILAE Women Task Force
    Epileptic disorders : international epilepsy journal with videotape, 2022, 12-01, Volume: 24, Issue:6

    Topics: Breast Feeding; Cannabidiol; Carbamazepine; Child; Clobazam; Clonazepam; Epilepsy; Ethosuximide; Eve

2022
[Paediatric status epilepticus].
    Revista de neurologia, 2022, 10-16, Volume: 75, Issue:8

    Topics: Adult; Anesthetics; Anticonvulsants; Benzodiazepines; Child; Epilepsy; Humans; Ketamine; Lacosamide;

2022
Effects of Maternal Use of Antiseizure Medications on Child Development.
    Neurologic clinics, 2022, Volume: 40, Issue:4

    Topics: Anticonvulsants; Child; Child Development; Epilepsy; Female; Folic Acid; Humans; Pregnancy; Pregnanc

2022
Refractory Convulsive Status Epilepticus Provoked by Intoxication with Dalfampridine in a Patient with Multiple Sclerosis and Depression Disorder: A Case Report and Literature Review.
    Acta neurologica Taiwanica, 2023, Mar-30, Volume: 32(1)

    Topics: 4-Aminopyridine; Adult; Epilepsy; Humans; Multiple Sclerosis; Sodium; Status Epilepticus; Valproic A

2023
Refractory Convulsive Status Epilepticus Provoked by Intoxication with Dalfampridine in a Patient with Multiple Sclerosis and Depression Disorder: A Case Report and Literature Review.
    Acta neurologica Taiwanica, 2023, Mar-30, Volume: 32(1)

    Topics: 4-Aminopyridine; Adult; Epilepsy; Humans; Multiple Sclerosis; Sodium; Status Epilepticus; Valproic A

2023
Refractory Convulsive Status Epilepticus Provoked by Intoxication with Dalfampridine in a Patient with Multiple Sclerosis and Depression Disorder: A Case Report and Literature Review.
    Acta neurologica Taiwanica, 2023, Mar-30, Volume: 32(1)

    Topics: 4-Aminopyridine; Adult; Epilepsy; Humans; Multiple Sclerosis; Sodium; Status Epilepticus; Valproic A

2023
Refractory Convulsive Status Epilepticus Provoked by Intoxication with Dalfampridine in a Patient with Multiple Sclerosis and Depression Disorder: A Case Report and Literature Review.
    Acta neurologica Taiwanica, 2023, Mar-30, Volume: 32(1)

    Topics: 4-Aminopyridine; Adult; Epilepsy; Humans; Multiple Sclerosis; Sodium; Status Epilepticus; Valproic A

2023
Valproate, divalproex, valpromide: Are the differences in indications justified?
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 158

    Topics: Bipolar Disorder; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Humans; Valproic Acid

2023
Valproate, divalproex, valpromide: Are the differences in indications justified?
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 158

    Topics: Bipolar Disorder; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Humans; Valproic Acid

2023
Valproate, divalproex, valpromide: Are the differences in indications justified?
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 158

    Topics: Bipolar Disorder; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Humans; Valproic Acid

2023
Valproate, divalproex, valpromide: Are the differences in indications justified?
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 158

    Topics: Bipolar Disorder; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Humans; Valproic Acid

2023
Kidney tubular injury induced by valproic acid: systematic literature review.
    Pediatric nephrology (Berlin, Germany), 2023, Volume: 38, Issue:6

    Topics: Epilepsy; Humans; Kidney; Kidney Tubules, Proximal; Proteinuria; Valproic Acid

2023
Epilepsy and brain tumors: Two sides of the same coin.
    Journal of the neurological sciences, 2023, 03-15, Volume: 446

    Topics: Anticonvulsants; Brain Neoplasms; Epilepsy; Humans; Levetiracetam; Valproic Acid

2023
Let food be thy medicine. The interaction between ketogenic diet therapy and anti-seizure medications: A systematic review.
    Epileptic disorders : international epilepsy journal with videotape, 2023, Volume: 25, Issue:1

    Topics: Anticonvulsants; Child; Diet, Ketogenic; Epilepsy; Humans; Ketone Bodies; Topiramate; Valproic Acid

2023
[Medical Treatment of Epilepsy].
    Brain and nerve = Shinkei kenkyu no shinpo, 2023, Volume: 75, Issue:4

    Topics: Anticonvulsants; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam; Seizures; Valproic Acid

2023
Management of epilepsy during pregnancy and lactation.
    BMJ (Clinical research ed.), 2023, 09-08, Volume: 382

    Topics: Breast Feeding; Epilepsy; Female; Humans; Lactation; Pregnancy; Prospective Studies; Seizures; Valpr

2023
Risk factors of hyperammonemia in epilepsy patients with valproic acid therapy.
    Clinical neurology and neurosurgery, 2023, Volume: 233

    Topics: Adult; Ammonia; Anticonvulsants; Epilepsy; Humans; Hyperammonemia; Risk Factors; Topiramate; Valproi

2023
Bipolar mania and epilepsy pathophysiology and treatment may converge in purine metabolism: A new perspective on available evidence.
    Neuropharmacology, 2023, Dec-15, Volume: 241

    Topics: Adenosine; Adenosine Triphosphate; Antimanic Agents; Bipolar Disorder; Epilepsy; Humans; Hydrocortis

2023
Effects of Second-Generation Antiepileptic Drugs Compared to First-Generation Antiepileptic Drugs on Bone Metabolism in Patients with Epilepsy: A Meta-Analysis.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2019, Volume: 51, Issue:8

    Topics: Anticonvulsants; Bone and Bones; Carbamazepine; Clinical Trials as Topic; Epilepsy; Humans; Lamotrig

2019
Effects of valproic acid on bone mineral density and bone metabolism: A meta-analysis.
    Seizure, 2019, Volume: 73

    Topics: Anticonvulsants; Bone and Bones; Bone Density; Epilepsy; Humans; Valproic Acid

2019
L-carnitine supplementation as a potential therapy for suspected hyperammonaemic encephalopathy.
    The journal of the Royal College of Physicians of Edinburgh, 2019, Volume: 49, Issue:4

    Topics: Adult; Anticonvulsants; Blood Chemical Analysis; Carnitine; Cerebral Palsy; Dietary Supplements; Epi

2019
Valproate, sexual health, and men: A narrative review.
    Epilepsy & behavior : E&B, 2020, Volume: 103, Issue:Pt A

    Topics: Anticonvulsants; Epilepsy; Erectile Dysfunction; Female; Humans; Male; Sexual Behavior; Sexual Dysfu

2020
Therapeutic Drug Monitoring of Antiepileptic Drugs in Women with Epilepsy Before, During, and After Pregnancy.
    Clinical pharmacokinetics, 2020, Volume: 59, Issue:4

    Topics: Anticonvulsants; Drug Monitoring; Epilepsy; Female; Humans; Postpartum Period; Pregnancy; Pregnancy

2020
Pharmacodynamic interactions of antiepileptic drugs: From bench to clinical practice.
    Epilepsy & behavior : E&B, 2020, Volume: 104, Issue:Pt A

    Topics: Animals; Anticonvulsants; Drug Evaluation, Preclinical; Drug Interactions; Drug Therapy, Combination

2020
Effects of valproic acid on skeletal metabolism in children with epilepsy: a systematic evaluation and meta-analysis based on 14 studies.
    BMC pediatrics, 2020, 03-02, Volume: 20, Issue:1

    Topics: Anticonvulsants; Bone Density; Child; Epilepsy; Female; Humans; Male; Retrospective Studies; Valproi

2020
Expert opinion: use of valproate in girls and women of childbearing potential with epilepsy: recommendations and alternatives based on a review of the literature and clinical experience-a European perspective.
    Journal of neurology, 2021, Volume: 268, Issue:8

    Topics: Anticonvulsants; Child; Epilepsy; Epilepsy, Generalized; Female; Humans; Pregnancy; Pregnancy Compli

2021
Influence of CYP2C9 and CYP2A6 on plasma concentrations of valproic acid: a meta-analysis.
    European journal of clinical pharmacology, 2020, Volume: 76, Issue:8

    Topics: Anticonvulsants; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2C9; Epilepsy; Humans; Valproic Acid

2020
Lessons learned from the discovery of sodium valproate and what has this meant to future drug discovery efforts?
    Expert opinion on drug discovery, 2020, Volume: 15, Issue:11

    Topics: Animals; Anticonvulsants; Drug Design; Drug Development; Drug Discovery; Drug Repositioning; Epileps

2020
The changes of serum zinc, copper, and selenium levels in epileptic patients: a systematic review and meta-analysis.
    Expert review of clinical pharmacology, 2020, Volume: 13, Issue:9

    Topics: Anticonvulsants; Copper; Diet; Epilepsy; Humans; Selenium; Trace Elements; Valproic Acid; Zinc

2020
Epilepsy in Angelman syndrome: A scoping review.
    Brain & development, 2021, Volume: 43, Issue:1

    Topics: Angelman Syndrome; Anticonvulsants; Child; Child, Preschool; Electroencephalography; Epilepsy; Femal

2021
[Transfer Mechanisms of Compounds between Mother and Fetus/Infant Aimed for Optimized Medication during Pregnancy and Breastfeeding].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2020, Volume: 140, Issue:10

    Topics: Anticonvulsants; Benzodiazepines; Biological Transport; Breast Feeding; Cell Line; Epilepsy; Female;

2020
The characterization of psychotic symptoms in succinic semialdehyde dehydrogenase deficiency: a review.
    Psychiatric genetics, 2020, Volume: 30, Issue:6

    Topics: Adolescent; Age of Onset; Aggression; Amino Acid Metabolism, Inborn Errors; Anticonvulsants; Anxiety

2020
Reproductive health in patients with epilepsy.
    Epilepsy & behavior : E&B, 2020, Volume: 113

    Topics: Anticonvulsants; Epilepsy; Female; Gonadal Steroid Hormones; Humans; Infertility, Female; Infertilit

2020
Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications.
    Current neuropharmacology, 2021, Volume: 19, Issue:11

    Topics: Anticonvulsants; Breast Feeding; Carbamazepine; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam

2021
Cosmetic adverse effects of antiseizure medications; A systematic review.
    Seizure, 2021, Volume: 91

    Topics: Animals; Anticonvulsants; Epilepsy; Humans; Phenytoin; Quality of Life; Valproic Acid

2021
Initial Management of Seizure in Adults.
    The New England journal of medicine, 2021, 07-15, Volume: 385, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Diagnosis, Differential; Electroencephalography; Epilepsy; Ethan

2021
Effects of Sodium Valproate Monotherapy on Blood Liver Enzyme Levels in Patients with Epilepsy: A Meta-Analysis.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2021, Volume: 53, Issue:7

    Topics: Alanine Transaminase; Anticonvulsants; Aspartate Aminotransferases; Epilepsy; gamma-Glutamyltransfer

2021
Neuropharmacology of Antiseizure Drugs.
    Neuropsychopharmacology reports, 2021, Volume: 41, Issue:3

    Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Humans; Neuropharmacology; Ph

2021
Pregnancy Outcomes Following In Utero Exposure to Lamotrigine: A Systematic Review and Meta-Analysis.
    CNS drugs, 2017, Volume: 31, Issue:6

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant, Newbo

2017
Association between switching antiepileptic drug products and healthcare utilization: A systematic review.
    Epilepsy & behavior : E&B, 2017, Volume: 73

    Topics: Adult; Anticonvulsants; Drug Substitution; Drugs, Generic; Epilepsy; Female; Fructose; Humans; Levet

2017
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.
    The Cochrane database of systematic reviews, 2017, 06-29, Volume: 6

    Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Epilepsies, Parti

2017
Comparative safety of antiepileptic drugs for neurological development in children exposed during pregnancy and breast feeding: a systematic review and network meta-analysis.
    BMJ open, 2017, Jul-20, Volume: 7, Issue:7

    Topics: Anticonvulsants; Autistic Disorder; Bayes Theorem; Breast Feeding; Carbamazepine; Child; Epilepsy; F

2017
The pharmacogenomics of valproic acid.
    Journal of human genetics, 2017, Volume: 62, Issue:12

    Topics: Anticonvulsants; Bipolar Disorder; Cytochrome P-450 Enzyme System; Drug Delivery Systems; Epilepsy;

2017
Relevance of CYP2C9 Function in Valproate Therapy.
    Current neuropharmacology, 2019, Volume: 17, Issue:1

    Topics: Adult; Age Factors; Anticonvulsants; Biosynthetic Pathways; Child; Cytochrome P-450 CYP2C9; Epilepsy

2019
Effect of UGT2B7 genotypes on plasma concentration of valproic acid: a meta-analysis.
    European journal of clinical pharmacology, 2018, Volume: 74, Issue:4

    Topics: Anticonvulsants; Chi-Square Distribution; Epilepsy; Gene Frequency; Glucuronosyltransferase; Heteroz

2018
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.
    The Cochrane database of systematic reviews, 2017, 12-15, Volume: 12

    Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Epilepsies, Parti

2017
Comparative efficacy of antiepileptic drugs in children and adolescents: A network meta-analysis.
    Epilepsia, 2018, Volume: 59, Issue:2

    Topics: Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Carbamazepine; Ch

2018
The effect of antiepileptic drugs on thyroid hormonal function: valproic acid and phenobarbital.
    Acta neurologica Belgica, 2020, Volume: 120, Issue:3

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Hypothyroidism; Inci

2020
Valproate: life-saving, life-changing.
    Clinical medicine (London, England), 2018, 04-01, Volume: 18, Issue:Suppl 2

    Topics: Anticonvulsants; England; Epilepsy; Female; Humans; Maternal Exposure; Practice Guidelines as Topic;

2018
Sodium valproate in pregnancy: what are the risks and should we use a shared decision-making approach?
    BMC pregnancy and childbirth, 2018, Jun-01, Volume: 18, Issue:1

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Decision Making; E

2018
[Valproate in the treatment of epilepsy and status epilepticus].
    Ideggyogyaszati szemle, 2017, Jul-30, Volume: 70, Issue:7-8

    Topics: Anticonvulsants; Epilepsy; Humans; Status Epilepticus; Valproic Acid

2017
Effects of valproate on reproductive endocrine function in male patients with epilepsy: A systematic review and meta-analysis.
    Epilepsy & behavior : E&B, 2018, Volume: 85

    Topics: Anticonvulsants; Epilepsy; Follicle Stimulating Hormone; Humans; Male; Observational Studies as Topi

2018
Lesson of the month 1: Sodium valproate-induced encephalopathy.
    Clinical medicine (London, England), 2018, Volume: 18, Issue:5

    Topics: Aged; Ammonia; Anticonvulsants; Brain Diseases; Carnitine; Consciousness Disorders; Epilepsy; Humans

2018
Association between SCN1A polymorphism rs3812718 and valproic acid resistance in epilepsy children: a case-control study and meta-analysis.
    Bioscience reports, 2018, 12-21, Volume: 38, Issue:6

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Resistance; Epilepsy; Female; Genetic Ass

2018
Valproic Acid and Epilepsy: From Molecular Mechanisms to Clinical Evidences.
    Current neuropharmacology, 2019, Volume: 17, Issue:10

    Topics: Animals; Anticonvulsants; Brain Injuries, Traumatic; Epilepsy; Histone Deacetylases; Humans; Neurons

2019
'Conceivably Neglected' - Are prescribers sufficiently aware of the risks of prescribing sodium valproate to women with mental illness?
    Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists, 2019, Volume: 27, Issue:2

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Epilepsy; Female;

2019
Valproic acid and Stevens-Johnson syndrome: a systematic review of descriptive studies.
    International journal of dermatology, 2019, Volume: 58, Issue:9

    Topics: Anticonvulsants; Antimanic Agents; Bipolar Disorder; Dose-Response Relationship, Drug; Epilepsy; Hum

2019
Choice of therapeutic anti-seizure medication in patients with brain tumour.
    JPMA. The Journal of the Pakistan Medical Association, 2019, Volume: 69, Issue:3

    Topics: Anticonvulsants; Brain Neoplasms; Drug Therapy, Combination; Epilepsy; Gabapentin; Glioma; Humans; L

2019
Valproic Acid and the Liver Injury in Patients with Epilepsy: An Update.
    Current pharmaceutical design, 2019, Volume: 25, Issue:3

    Topics: Anticonvulsants; Antioxidants; Carnitine; Chemical and Drug Induced Liver Injury; Epilepsy; Humans;

2019
Epilepsy in patients with EAST syndrome caused by mutation in the KCNJ10.
    Brain & development, 2019, Volume: 41, Issue:8

    Topics: Anticonvulsants; Brain; Carbamazepine; Cerebellar Ataxia; Child; Child, Preschool; Epilepsy; Female;

2019
Risk of valproic acid-related alopecia: A systematic review and meta-analysis.
    Seizure, 2019, Volume: 69

    Topics: Alopecia; Anticonvulsants; Epilepsy; Humans; Incidence; Prospective Studies; Valproic Acid

2019
CPS1 T1405N polymorphism, HDL cholesterol, homocysteine and renal function are risk factors of VPA induced hyperammonemia among epilepsy patients.
    Epilepsy research, 2019, Volume: 154

    Topics: Anticonvulsants; Carbamoyl-Phosphate Synthase (Ammonia); Case-Control Studies; Cholesterol, HDL; Epi

2019
Valproate decreases vitamin D levels in pediatric patients with epilepsy.
    Seizure, 2019, Volume: 71

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Humans; Valproic Acid

2019
Clinical opinion: Earlier employment of polytherapy in sequential pharmacotherapy of epilepsy.
    Epilepsy research, 2019, Volume: 156

    Topics: Anticonvulsants; Drug Resistant Epilepsy; Drug Therapy, Combination; Epilepsy; Humans; Lamotrigine;

2019
Seizures and intracranial hemorrhage.
    Obstetrics and gynecology clinics of North America, 2013, Volume: 40, Issue:1

    Topics: Anticonvulsants; Carbamazepine; Congenital Abnormalities; Eclampsia; Epilepsy; Female; Folic Acid; H

2013
The effects of sodium valproate on the renal function of children with epilepsy.
    Pediatric nephrology (Berlin, Germany), 2014, Volume: 29, Issue:7

    Topics: Acetylglucosaminidase; Anticonvulsants; Child; Epilepsy; Fanconi Syndrome; Female; Humans; Kidney; M

2014
Adverse drug reactions induced by valproic acid.
    Clinical biochemistry, 2013, Volume: 46, Issue:15

    Topics: Anticonvulsants; Antipsychotic Agents; Drug Hypersensitivity; Endocrine System; Epilepsy; Humans; Hy

2013
Metabolic and endocrine effects of valproic acid chronic treatment.
    Epilepsy research, 2013, Volume: 107, Issue:1-2

    Topics: Anticonvulsants; Epilepsy; Humans; Hyperinsulinism; Insulin Resistance; Leptin; Metabolic Syndrome;

2013
The search for better epilepsy treatments: from slime mould to coconuts.
    Biochemical Society transactions, 2013, Volume: 41, Issue:6

    Topics: Animals; Anticonvulsants; Cocos; Dictyostelium; Drug Discovery; Epilepsy; Humans; Valproic Acid

2013
Weight change, genetics and antiepileptic drugs.
    Expert review of clinical pharmacology, 2014, Volume: 7, Issue:1

    Topics: Animals; Anticonvulsants; Epilepsy; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; Huma

2014
Migraine and epilepsy in the pediatric population.
    Current pain and headache reports, 2014, Volume: 18, Issue:3

    Topics: Anticonvulsants; Child; Child, Preschool; Comorbidity; Diagnosis, Differential; Diet, Ketogenic; Epi

2014
Risks of neurobehavioral teratogenicity associated with prenatal exposure to valproate monotherapy: a systematic review with regulatory repercussions.
    CNS spectrums, 2014, Volume: 19, Issue:4

    Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Bipolar Di

2014
Treating epilepsy in pregnant women.
    Expert opinion on pharmacotherapy, 2014, Volume: 15, Issue:6

    Topics: Anticonvulsants; Congenital Abnormalities; Epilepsy; Female; Humans; Intellectual Disability; Matern

2014
WITHDRAWN: Traditional Chinese medicine for epilepsy.
    The Cochrane database of systematic reviews, 2014, Mar-11, Issue:3

    Topics: Anticonvulsants; Drugs, Chinese Herbal; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Medicine, Chinese

2014
Prediction of the hazard of foetal malformation in pregnant women with epilepsy.
    Epilepsy research, 2014, Volume: 108, Issue:6

    Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Australia; Epilepsy; Female; Humans; Pregnancy;

2014
[Clinical guidelines for epilepsy].
    Nihon rinsho. Japanese journal of clinical medicine, 2014, Volume: 72, Issue:5

    Topics: Anticonvulsants; Asia; Carbamazepine; Epilepsy; Europe; Evidence-Based Medicine; Humans; Internation

2014
[Treatment of pediatric epilepsy].
    Nihon rinsho. Japanese journal of clinical medicine, 2014, Volume: 72, Issue:5

    Topics: Adolescent; Amines; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cyclohexanecarboxylic A

2014
[Treatment of epilepsy in patients of adolescence and adulthood].
    Nihon rinsho. Japanese journal of clinical medicine, 2014, Volume: 72, Issue:5

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Combined Modality Therapy; Drug Substitution; Epi

2014
Increased homocysteine levels in valproate-treated patients with epilepsy: a meta-analysis.
    BMJ open, 2014, Jul-16, Volume: 4, Issue:7

    Topics: Anticonvulsants; Epilepsy; Homocysteine; Humans; Valproic Acid

2014
Valproic acid and fatalities in children: a review of individual case safety reports in VigiBase.
    PloS one, 2014, Volume: 9, Issue:10

    Topics: Adverse Drug Reaction Reporting Systems; Anticonvulsants; Chemical and Drug Induced Liver Injury; Ch

2014
Treatment for epilepsy in pregnancy: neurodevelopmental outcomes in the child.
    The Cochrane database of systematic reviews, 2014, Oct-30, Issue:10

    Topics: Age Factors; Anticonvulsants; Carbamazepine; Child; Developmental Disabilities; Epilepsy; Female; Hu

2014
[Epilepsy, antiepileptic drugs and disorders of reproductive functions of women].
    Przeglad lekarski, 2014, Volume: 71, Issue:10

    Topics: Anticonvulsants; Epilepsy; Female; Fetal Diseases; Humans; Infertility, Female; Polycystic Ovary Syn

2014
Valproate in the treatment of epilepsy in girls and women of childbearing potential.
    Epilepsia, 2015, Volume: 56, Issue:7

    Topics: Age Factors; Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Prenatal Exposure Delayed Effects

2015
Pharmacological treatments for preventing epilepsy following traumatic head injury.
    The Cochrane database of systematic reviews, 2015, Aug-10, Issue:8

    Topics: Adult; Anticonvulsants; Carbamazepine; Cause of Death; Child; Craniocerebral Trauma; Epilepsy; Human

2015
[Algorithms of using valproic acid drugs in women].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2015, Volume: 115, Issue:4

    Topics: Algorithms; Anticonvulsants; Contraindications; Epilepsy; Female; Humans; Pregnancy; Pregnancy Compl

2015
Is carbamazepine a human teratogen?
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2016, Volume: 23

    Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Australia; Carbamazepine; Epilepsy; Female; Fet

2016
Valproic acid after five decades of use in epilepsy: time to reconsider the indications of a time-honoured drug.
    The Lancet. Neurology, 2016, Volume: 15, Issue:2

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Prenatal Exposure

2016
Reflex epileptic mechanisms in ictogenesis and therapeutic consequences.
    Expert review of neurotherapeutics, 2016, Volume: 16, Issue:5

    Topics: Epilepsies, Partial; Epilepsy; Epilepsy, Reflex; Humans; Seizures; Valproic Acid

2016
[Preconceptional and perinatal challenges of pregnancy in women with epilepsy].
    Orvosi hetilap, 2016, Apr-10, Volume: 157, Issue:15

    Topics: Adult; Amines; Anticonvulsants; Benzodiazepines; Carbamazepine; Cyclohexanecarboxylic Acids; Epileps

2016
[Dynamin-1-related infantile spasms: a case report and review of literature].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2016, Nov-02, Volume: 54, Issue:11

    Topics: Child; Child, Preschool; Developmental Disabilities; Dynamin I; Electroencephalography; Epilepsy; Fe

2016
Menstrual cycle dysfunction associated with neurologic and psychiatric disorders: their treatment in adolescents.
    Annals of the New York Academy of Sciences, 2008, Volume: 1135

    Topics: Adolescent; Amenorrhea; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Bone and Bones; Epi

2008
Teratogenicity of antiepileptic medications.
    Seminars in neurology, 2008, Volume: 28, Issue:3

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Drug Interactions; Drug Therapy, Combination; Epilepsy

2008
[Diagnosis and treatment of epilepsy in the field of psychiatry].
    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 2008, Volume: 110, Issue:7

    Topics: Adult; Anticonvulsants; Carbamazepine; Diazepam; Electroencephalography; Epilepsy; Female; Humans; M

2008
Epileptic disorders in pregnancy: an overview.
    Current opinion in obstetrics & gynecology, 2008, Volume: 20, Issue:6

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Folic Acid; Hemorrhag

2008
Polycystic ovary syndrome in women using valproate: a review.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2008, Volume: 24, Issue:10

    Topics: Antimanic Agents; Bipolar Disorder; Epilepsy; Female; Humans; Polycystic Ovary Syndrome; Prevalence;

2008
Valproate-induced insulin resistance and obesity in children.
    Hormone research, 2009, Volume: 71, Issue:3

    Topics: Anticonvulsants; Child; Epilepsy; Humans; Insulin Resistance; Obesity; Valproic Acid; Weight Gain

2009
[Do results of the recent clinical trials change the place of valproate in treatment of epilepsy?].
    Przeglad lekarski, 2008, Volume: 65, Issue:11

    Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; Humans; Seizures; Valproic Acid

2008
Genetic basis for idiosyncratic reactions to antiepileptic drugs.
    Current opinion in neurology, 2009, Volume: 22, Issue:2

    Topics: Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Epile

2009
Practice parameter update: management issues for women with epilepsy--focus on pregnancy (an evidence-based review): teratogenesis and perinatal outcomes: report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee
    Neurology, 2009, Jul-14, Volume: 73, Issue:2

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Birth Weight; Cognition Disorders; Contraindications;

2009
Management issues for women with epilepsy-Focus on pregnancy (an evidence-based review): II. Teratogenesis and perinatal outcomes: Report of the Quality Standards Subcommittee and Therapeutics and Technology Subcommittee of the American Academy of Neurolo
    Epilepsia, 2009, Volume: 50, Issue:5

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Birth Weight; Cognition Disorders; Contraindications;

2009
Traditional Chinese medicine for epilepsy.
    The Cochrane database of systematic reviews, 2009, Jul-08, Issue:3

    Topics: Anticonvulsants; Drugs, Chinese Herbal; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Medicine, Chinese

2009
Rational polytherapy.
    Epilepsia, 2009, Volume: 50 Suppl 8

    Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Inter

2009
Structure-function studies for the panacea, valproic acid.
    Biochemical Society transactions, 2009, Volume: 37, Issue:Pt 5

    Topics: Animals; Anticonvulsants; Bipolar Disorder; Epilepsy; gamma-Aminobutyric Acid; Glycogen Synthase Kin

2009
New antiepileptic drugs: molecular targets.
    Central nervous system agents in medicinal chemistry, 2009, Volume: 9, Issue:2

    Topics: Action Potentials; Animals; Anticonvulsants; Barbiturates; Carbamazepine; Clinical Trials as Topic;

2009
[Homocysteine and asymmetric dimethylarginine (ADMA) in epilepsy].
    Przeglad lekarski, 2009, Volume: 66, Issue:8

    Topics: Anticonvulsants; Arginine; Carbamazepine; Epilepsy; Homocysteine; Humans; Nitric Oxide; Nitric Oxide

2009
Psychiatric concerns in pediatric epilepsy.
    Child and adolescent psychiatric clinics of North America, 2010, Volume: 19, Issue:2

    Topics: Adolescent; Amines; Anxiety Disorders; Bipolar Disorder; Child; Child, Preschool; Cyclohexanecarboxy

2010
Molecular and therapeutic potential and toxicity of valproic acid.
    Journal of biomedicine & biotechnology, 2010, Volume: 2010

    Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; gamma-Aminobutyric Acid; Histone Deacetylase In

2010
Molecular and therapeutic potential and toxicity of valproic acid.
    Journal of biomedicine & biotechnology, 2010, Volume: 2010

    Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; gamma-Aminobutyric Acid; Histone Deacetylase In

2010
Molecular and therapeutic potential and toxicity of valproic acid.
    Journal of biomedicine & biotechnology, 2010, Volume: 2010

    Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; gamma-Aminobutyric Acid; Histone Deacetylase In

2010
Molecular and therapeutic potential and toxicity of valproic acid.
    Journal of biomedicine & biotechnology, 2010, Volume: 2010

    Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; gamma-Aminobutyric Acid; Histone Deacetylase In

2010
Molecular and therapeutic potential and toxicity of valproic acid.
    Journal of biomedicine & biotechnology, 2010, Volume: 2010

    Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; gamma-Aminobutyric Acid; Histone Deacetylase In

2010
Molecular and therapeutic potential and toxicity of valproic acid.
    Journal of biomedicine & biotechnology, 2010, Volume: 2010

    Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; gamma-Aminobutyric Acid; Histone Deacetylase In

2010
Molecular and therapeutic potential and toxicity of valproic acid.
    Journal of biomedicine & biotechnology, 2010, Volume: 2010

    Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; gamma-Aminobutyric Acid; Histone Deacetylase In

2010
Molecular and therapeutic potential and toxicity of valproic acid.
    Journal of biomedicine & biotechnology, 2010, Volume: 2010

    Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; gamma-Aminobutyric Acid; Histone Deacetylase In

2010
Molecular and therapeutic potential and toxicity of valproic acid.
    Journal of biomedicine & biotechnology, 2010, Volume: 2010

    Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; gamma-Aminobutyric Acid; Histone Deacetylase In

2010
Weight gain following treatment with valproic acid: pathogenetic mechanisms and clinical implications.
    Obesity reviews : an official journal of the International Association for the Study of Obesity, 2011, Volume: 12, Issue:5

    Topics: Androgens; Anticonvulsants; Epilepsy; Female; Humans; Insulin Resistance; Male; Metabolic Syndrome;

2011
Epilepsy (generalised).
    BMJ clinical evidence, 2010, Jun-22, Volume: 2010

    Topics: Anticonvulsants; Carbamazepine; Epilepsy; Epilepsy, Generalized; Humans; Incidence; Phenytoin; Remis

2010
[Rational combinations of antiepileptic drugs for refractory epilepsy].
    Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 2011, Volume: 31, Issue:2

    Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbamazepine; Cl

2011
[Pregabalin and gabapentin in multiple sclerosis: clinical experiences and therapeutic implications].
    Der Nervenarzt, 2011, Volume: 82, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Amines; Anticonvulsants; Antineoplastic Agents; Carbamazepine; Cohor

2011
A meta-analysis of polycystic ovary syndrome in women taking valproate for epilepsy.
    Epilepsy research, 2011, Volume: 97, Issue:1-2

    Topics: Anticonvulsants; Epilepsy; Female; Humans; Incidence; Polycystic Ovary Syndrome; Risk Factors; Valpr

2011
Side effects of phenobarbital in epilepsy: a systematic review.
    Epileptic disorders : international epilepsy journal with videotape, 2011, Volume: 13, Issue:4

    Topics: Anticonvulsants; Carbamazepine; Child; Cognition Disorders; Cohort Studies; Cross-Over Studies; Data

2011
Takotsubo syndrome (TKS): a possible mechanism of sudden unexplained death in epilepsy (SUDEP).
    Seizure, 2012, Volume: 21, Issue:1

    Topics: Adrenergic beta-1 Receptor Antagonists; Anticonvulsants; Aspirin; Bisoprolol; Death, Sudden; Epileps

2012
Management of acute seizure and status epilepticus in pediatric emergency.
    Indian journal of pediatrics, 2012, Volume: 79, Issue:4

    Topics: Anesthesia, Intravenous; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Combined Modalit

2012
Epilepsy (generalised).
    BMJ clinical evidence, 2012, Feb-20, Volume: 2012

    Topics: Anticonvulsants; Carbamazepine; Epilepsy; Epilepsy, Generalized; Humans; Incidence; Phenytoin; Remis

2012
Efficacy and safety of innovator versus generic drugs in patients with epilepsy: a systematic review.
    Pharmacotherapy, 2012, Volume: 32, Issue:4

    Topics: Anticonvulsants; Carbamazepine; Data Interpretation, Statistical; Dose-Response Relationship, Drug;

2012
Neuroconnectivity and valproic acid: the myelin hypothesis.
    Neuroscience and biobehavioral reviews, 2012, Volume: 36, Issue:8

    Topics: Animals; Brain; Epilepsy; Humans; Models, Animal; Myelin Sheath; Neuroimaging; Valproic Acid

2012
SCN1A IVS5N+5 polymorphism and response to sodium valproate: a multicenter study.
    Pharmacogenomics, 2012, Volume: 13, Issue:13

    Topics: Adolescent; Adult; Alternative Splicing; Anticonvulsants; Asian People; Child; Cohort Studies; Epile

2012
Extended-release antiepileptic drugs: a comparison of pharmacokinetic parameters relative to original immediate-release formulations.
    Epilepsia, 2013, Volume: 54, Issue:1

    Topics: Anticonvulsants; Carbamazepine; Delayed-Action Preparations; Drug Tolerance; Epilepsy; Humans; Valpr

2013
[Medication-related oculogyric crises: a description of four cases and a review of the literature].
    Revista de neurologia, 2013, Feb-01, Volume: 56, Issue:3

    Topics: Adolescent; Anticonvulsants; Antipsychotic Agents; Aripiprazole; Child; Child Behavior Disorders; Ch

2013
DP-VPA D-Pharm.
    Current opinion in investigational drugs (London, England : 2000), 2002, Volume: 3, Issue:6

    Topics: Animals; Bipolar Disorder; Clinical Trials, Phase II as Topic; Drug Evaluation, Preclinical; Epileps

2002
Epilepsy and pregnancy.
    Seizure, 2002, Volume: 11 Suppl A

    Topics: Anticonvulsants; Embryonic and Fetal Development; Epilepsy; Female; Fetal Diseases; Folic Acid; Huma

2002
Medical genetics: 1. Clinical teratology in the age of genomics.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2002, Aug-06, Volume: 167, Issue:3

    Topics: Adult; Alcohol Drinking; Anticonvulsants; Environmental Exposure; Epilepsy; Female; Genetic Counseli

2002
Pharmacological and therapeutic properties of valproate: a summary after 35 years of clinical experience.
    CNS drugs, 2002, Volume: 16, Issue:10

    Topics: Anticonvulsants; Clinical Trials as Topic; Drug Interactions; Epilepsy; History, 20th Century; Histo

2002
Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy.
    CNS drugs, 2002, Volume: 16, Issue:10

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Dopamine; Epilepsy; Excitatory Amino Acids; gamma-

2002
Valproate and neuroprotection.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2002, Volume: 9, Issue:5

    Topics: Animals; Anticonvulsants; Biomarkers; Epilepsy; Humans; Neuroprotective Agents; Neurotransmitter Age

2002
[Epilepsy with continuous spikes and waves during slow sleep].
    Ryoikibetsu shokogun shirizu, 2002, Issue:37 Pt 6

    Topics: Adolescent; Child; Clonazepam; Diagnosis, Differential; Drug Therapy, Combination; Electroencephalog

2002
Drug treatment of epilepsy in elderly people: focus on valproic Acid.
    Drugs & aging, 2003, Volume: 20, Issue:2

    Topics: Aged; Aging; Anticonvulsants; Clinical Trials as Topic; Drug Interactions; Epilepsy; Humans; Treatme

2003
New CNS-active drugs which are second-generation valproic acid: can they lead to the development of a magic bullet?
    Current opinion in neurology, 2003, Volume: 16, Issue:2

    Topics: Amides; Anticonvulsants; Bipolar Disorder; Epilepsy; Humans; Migraine Disorders; Valproic Acid

2003
Pancreatic pseudocyst caused by valproic acid: case report and review of the literature.
    European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie, 2003, Volume: 13, Issue:1

    Topics: Amylases; Anticonvulsants; Child; Epilepsy; Female; Humans; Pancreatic Pseudocyst; Pancreatitis; Val

2003
Acute pancreatitis in children from Valproic acid: case series and review.
    Pediatric neurology, 2003, Volume: 28, Issue:2

    Topics: Acute Disease; Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Fatal Outcome; Female

2003
A study of EEG and epilepsy profile in Wolf-Hirschhorn syndrome and considerations regarding its correlation with other chromosomal disorders.
    Brain & development, 2003, Volume: 25, Issue:4

    Topics: Angelman Syndrome; Anticonvulsants; Child; Chromosome Deletion; Chromosome Disorders; Chromosomes, H

2003
Polycystic ovary syndrome and epilepsy: a review of the evidence.
    Drugs, 2003, Volume: 63, Issue:12

    Topics: Adolescent; Adult; Anticonvulsants; Clinical Trials as Topic; Epilepsy; Female; Humans; Menstruation

2003
Valproate: past, present, and future.
    CNS drug reviews, 2003,Summer, Volume: 9, Issue:2

    Topics: Animals; Anticonvulsants; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Epilep

2003
Management issues for women with epilepsy: neural tube defects and folic acid supplementation.
    Neurology, 2003, Sep-01, Volume: 61, Issue:6 Suppl 2

    Topics: Adult; Animals; Anticonvulsants; Carbamazepine; Cleft Lip; Cleft Palate; Epilepsy; Female; Folic Aci

2003
Epilepsy: from consensus to daily practice.
    Acta neurologica Scandinavica. Supplementum, 2003, Volume: 180

    Topics: Adult; Anticonvulsants; Decision Making; Drug Therapy, Combination; Epilepsy; Evidence-Based Medicin

2003
Prevention of epilepsy after head trauma: do we need new drugs or a new approach?
    Epilepsia, 2003, Volume: 44, Issue:s10

    Topics: Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Drug Administration Schedule; Epi

2003
Divalproex and epilepsy.
    Psychopharmacology bulletin, 2003, Volume: 37 Suppl 2

    Topics: Anticonvulsants; Drug Interactions; Epilepsy; Humans; Valproic Acid

2003
[Clinical guidelines for treatment of epilepsy in children].
    No to hattatsu = Brain and development, 2004, Volume: 36, Issue:2

    Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Cosyntropin; Electroencephalography; Epileps

2004
[Effect of anti-epileptic drugs on human placenta and the fetus].
    Ginekologia polska, 2004, Volume: 75, Issue:2

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Embryonic and Fetal Development; Epilepsy; Female; Fet

2004
Correlating lamotrigine serum concentrations with tolerability in patients with epilepsy.
    Neurology, 2004, Sep-28, Volume: 63, Issue:6

    Topics: Anticonvulsants; Dose-Response Relationship, Drug; Drug Eruptions; Drug Interactions; Drug Therapy,

2004
[Therapy of epilepsy: current strategy and tactics].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2004, Volume: 104, Issue:8

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Age Factors; Anticonvulsants; Carbamazepine; Child;

2004
Cancer risk in people with epilepsy: the role of antiepileptic drugs.
    Brain : a journal of neurology, 2005, Volume: 128, Issue:Pt 1

    Topics: Animals; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Neoplasms; Phenobarbital; Phenytoin; Rats

2005
[A case of valproate-associated hyperammonemia with chronic hepatitis C].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 2005, Volume: 102, Issue:1

    Topics: Anticonvulsants; Epilepsy; Hepatitis C, Chronic; Humans; Hyperammonemia; Male; Middle Aged; Valproic

2005
Teratogenicity of sodium valproate.
    Expert opinion on drug safety, 2005, Volume: 4, Issue:2

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Animals; Autistic Disorder; Cleft Lip;

2005
Pancreatitis, complicated by a pancreatic pseudocyst associated with the use of valproic acid.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2005, Volume: 9, Issue:2

    Topics: Acute Disease; Anticonvulsants; Child; Epilepsy; Humans; Male; Pancreatic Pseudocyst; Pancreatitis;

2005
Management of epilepsy in women.
    Postgraduate medical journal, 2005, Volume: 81, Issue:955

    Topics: Anticonvulsants; Child; Contraceptives, Oral, Combined; Contraindications; Developmental Disabilitie

2005
Endocrine and metabolic changes in epileptic patients receiving valproic acid.
    Journal of pediatric endocrinology & metabolism : JPEM, 2005, Volume: 18, Issue:5

    Topics: Anticonvulsants; Child; Endocrine System; Epilepsy; Humans; Valproic Acid

2005
[Successful balloon-occluded retrograde transvenous obliteration (B-RTO) in a case of symptomatic epilepsy with hepatic encephalopathy due to non-cirrhotic porto-systemic shunt].
    Rinsho shinkeigaku = Clinical neurology, 2005, Volume: 45, Issue:5

    Topics: Aged; Anticonvulsants; Balloon Occlusion; Epilepsy; Hepatic Encephalopathy; Humans; Hyperammonemia;

2005
Valproate: a simple chemical with so much to offer.
    Journal of clinical pharmacy and therapeutics, 2005, Volume: 30, Issue:5

    Topics: Anticonvulsants; Chemical and Drug Induced Liver Injury; Epilepsy; Female; History, 20th Century; Hu

2005
Progress in pharmaceutical development presentation with improved pharmacokinetics: a new formulation for valproate.
    Acta neurologica Scandinavica. Supplementum, 2005, Volume: 182

    Topics: Administration, Oral; Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Chemistry, Pharmaceutic

2005
[Successful treatment with cyclosporine of sodium valproate-induced pure red cell aplasia].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2005, Volume: 46, Issue:10

    Topics: Aged; Anticonvulsants; Cyclosporine; Epilepsy; Humans; Immunosuppressive Agents; Male; Red-Cell Apla

2005
Valproic acid in epilepsy : pregnancy-related issues.
    Drug safety, 2006, Volume: 29, Issue:1

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Autistic Disorder; Epilepsy; Female; Humans; Infant, N

2006
Valproate as a mainstay of therapy for pediatric epilepsy.
    Paediatric drugs, 2006, Volume: 8, Issue:2

    Topics: Anticonvulsants; Child; Drug Monitoring; Epilepsy; Humans; Valproic Acid

2006
Recent advances on neural tube defects with special reference to Valproic Acid.
    Endocrine, metabolic & immune disorders drug targets, 2006, Volume: 6, Issue:1

    Topics: Adult; Animals; Anticonvulsants; Epilepsy; Epoxide Hydrolases; Female; Folic Acid; Folic Acid Defici

2006
New antiepileptic drugs that are second generation to existing antiepileptic drugs.
    Expert opinion on investigational drugs, 2006, Volume: 15, Issue:6

    Topics: Amines; Animals; Anticonvulsants; Bipolar Disorder; Carbamazepine; Cyclohexanecarboxylic Acids; Drug

2006
Role of valproate across the ages. Treatment of epilepsy in children.
    Acta neurologica Scandinavica. Supplementum, 2006, Volume: 184

    Topics: Anticonvulsants; Child; Epilepsies, Myoclonic; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epi

2006
Role of valproate across the ages. Treatment of epilepsy in adults.
    Acta neurologica Scandinavica. Supplementum, 2006, Volume: 184

    Topics: Adult; Age Factors; Anticonvulsants; Child; Developmental Disabilities; Epilepsy; Female; Fertility;

2006
Role of valproate across the ages. Treatment of epilepsy in the elderly.
    Acta neurologica Scandinavica. Supplementum, 2006, Volume: 184

    Topics: Aged; Contraindications; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Tolerance; Epilepsy

2006
[Epilepsy and male sexual dysfunction: etiology, diagnosis and therapy].
    Ideggyogyaszati szemle, 2006, May-20, Volume: 59, Issue:5-6

    Topics: Androgens; Anticonvulsants; Bromocriptine; Carbamazepine; Cognition; Enzyme Induction; Epilepsy; Gon

2006
Epilepsy and polycystic ovary syndrome: where is the link?
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2006, Volume: 27, Issue:4

    Topics: Epilepsy; Female; History, 20th Century; History, 21st Century; Humans; Models, Biological; Polycyst

2006
Treatment of interictal epileptiform discharges in cerebral palsy patients without clinical epilepsy: hope for a better outcome in prognosis.
    Clinical neurology and neurosurgery, 2007, Volume: 109, Issue:3

    Topics: Calcium Channels; Cerebral Palsy; Electroencephalography; Epilepsy; Glutamic Acid; Humans; Intracell

2007
Valproic Acid: second generation.
    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2007, Volume: 4, Issue:1

    Topics: Animals; Anticonvulsants; Brain; Clinical Trials as Topic; Epilepsy; Humans; Structure-Activity Rela

2007
[Anticonvulsants treatment of psychiatric disorder in elderly patients].
    Przeglad lekarski, 2006, Volume: 63, Issue:7

    Topics: Aged; Anticonvulsants; Anxiety Disorders; Bipolar Disorder; Carbamazepine; Epilepsy; Humans; Mental

2006
Therapeutic monitoring of antiepileptic drugs for epilepsy.
    The Cochrane database of systematic reviews, 2007, Jan-24, Issue:1

    Topics: Anticonvulsants; Carbamazepine; Drug Monitoring; Epilepsy; Humans; Phenobarbital; Phenytoin; Primido

2007
Antiepileptic drugs in migraine: from clinical aspects to cellular mechanisms.
    Trends in pharmacological sciences, 2007, Volume: 28, Issue:4

    Topics: Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Fructose; Gabapentin; gamma

2007
Teratogenesis of sodium valproate.
    Current opinion in neurology, 2007, Volume: 20, Issue:2

    Topics: Anticonvulsants; Developmental Disabilities; Epilepsy; Female; Humans; Infant, Newborn; Intellectual

2007
Idiosyncratic adverse reactions to antiepileptic drugs.
    Epilepsia, 2007, Volume: 48, Issue:7

    Topics: Age Factors; Anemia, Aplastic; Anticonvulsants; B-Lymphocytes; Central Nervous System Diseases; Chem

2007
[The role of the antiepileptic drugs at the development of the sexual dysfunctions in male epileptic patients].
    Ideggyogyaszati szemle, 2007, Jan-20, Volume: 60, Issue:1-2

    Topics: Anticonvulsants; Cytochrome P-450 Enzyme System; Drug Interactions; Epilepsy; Erectile Dysfunction;

2007
Leptin and insulin homeostasis in epilepsy: relation to weight adverse conditions.
    Epilepsy research, 2007, Volume: 75, Issue:1

    Topics: Animals; Anticonvulsants; Body Weight; Epilepsy; Homeostasis; Humans; Insulin; Leptin; Valproic Acid

2007
The mechanisms of action of valproate in neuropsychiatric disorders: can we see the forest for the trees?
    Cellular and molecular life sciences : CMLS, 2007, Volume: 64, Issue:16

    Topics: Animals; Anticonvulsants; beta Catenin; Bipolar Disorder; Brain; Enzyme Inhibitors; Epilepsy; Extrac

2007
New statistical method for analyzing time to first seizure: example using data comparing carbamazepine and valproate monotherapy.
    Epilepsia, 2007, Volume: 48, Issue:6

    Topics: Adult; Age Factors; Anticonvulsants; Carbamazepine; Child; Data Interpretation, Statistical; Epileps

2007
[New antiepileptics in development].
    Pharmazie in unserer Zeit, 2007, Volume: 36, Issue:4

    Topics: Animals; Anticonvulsants; Benzodiazepines; Carbamazepine; Epilepsy; Felbamate; Humans; Levetiracetam

2007
Extended-release formulations for the treatment of epilepsy.
    CNS drugs, 2007, Volume: 21, Issue:9

    Topics: Animals; Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury; Delayed-Action Prep

2007
The measurement of ammonia blood levels in patients taking valproic acid: looking for problems where they do not exist?
    Epilepsy & behavior : E&B, 2007, Volume: 11, Issue:3

    Topics: Ammonia; Anticonvulsants; Epilepsy; Female; Humans; Male; MEDLINE; Retrospective Studies; Valproic A

2007
Epilepsy in Angelman syndrome.
    Seizure, 2008, Volume: 17, Issue:3

    Topics: Angelman Syndrome; Electroencephalography; Epilepsy; Humans; Valproic Acid

2008
Valproate and neuroendocrine changes in relation to women treated for epilepsy and bipolar disorder: a review.
    Current medicinal chemistry, 2007, Volume: 14, Issue:26

    Topics: Anticonvulsants; Antimanic Agents; Bipolar Disorder; Contraceptives, Oral; Epilepsy; Female; Hormone

2007
The treatment of the first seizure: the benefits.
    Epilepsia, 2008, Volume: 49 Suppl 1

    Topics: Actuarial Analysis; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Phenobarbital; Prognosis; Rand

2008
Oral valproic acid for epilepsy--long-term experience in therapy and side effects.
    Expert opinion on pharmacotherapy, 2008, Volume: 9, Issue:2

    Topics: Administration, Oral; Animals; Anticonvulsants; Epilepsy; Gastrointestinal Diseases; Humans; Pancrea

2008
Antiepileptic drugs as human teratogens.
    Expert opinion on drug safety, 2008, Volume: 7, Issue:2

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Phenobarbital

2008
Clinical pharmacology of parenteral use of antiepileptic drugs.
    Epilepsia, 2007, Volume: 48 Suppl 8

    Topics: Anticonvulsants; Epilepsy; Humans; Infusions, Intravenous; Injections, Intravenous; Levetiracetam; P

2007
Psychopharmacological aspects of antiepileptic treatment.
    Progress in neurobiology, 1980, Volume: 15, Issue:2

    Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Electroencephalography; Epilepsy; Ethosux

1980
[Advance and clinic of antiepileptic drugs (author's transl)].
    Sheng li ke xue jin zhan [Progress in physiology], 1981, Volume: 12, Issue:3

    Topics: Animals; Anticonvulsants; Benzodiazepines; Brain; Carbamazepine; Epilepsy; Humans; Ion Channels; Mic

1981
Mechanism of anticonvulsant action of valproate.
    Progress in neurobiology, 1982, Volume: 19, Issue:4

    Topics: Animals; Aspartic Acid; Cats; Central Nervous System; Epilepsy; gamma-Aminobutyric Acid; Half-Life;

1982
Pharmacology of GABA.
    Clinical neuropharmacology, 1982, Volume: 5, Issue:3

    Topics: 4-Aminobutyrate Transaminase; Anxiety Disorders; Autonomic Nervous System; Barbiturates; Benzodiazep

1982
Diagnosis and treatment of epilepsy.
    Hospital & community psychiatry, 1983, Volume: 34, Issue:6

    Topics: Automatism; Benzodiazepines; Carbamazepine; Electroencephalography; Epilepsies, Partial; Epilepsy; E

1983
[Use of phenobarbital in febrile convulsive crisis].
    Anales espanoles de pediatria, 1983, Volume: 18, Issue:2

    Topics: Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Nervous System Diseases; Phenobarbital; Recurr

1983
Mental effects of antiepileptic medication: a review.
    Epilepsia, 1983, Volume: 24 Suppl 2

    Topics: Adolescent; Adult; Anticonvulsants; Attention; Barbiturates; Brain Chemistry; Carbamazepine; Child;

1983
Clinical pharmacokinetics of sodium valproate, carbamazepine and phenytoin. Level-dose ration and interactions.
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1984, Feb-07, Volume: 73, Issue:6

    Topics: Carbamazepine; Drug Interactions; Epilepsy; Humans; Intestinal Absorption; Kinetics; Phenytoin; Valp

1984
[Current progress in research and treatment of epilepsy].
    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 1984, Volume: 86, Issue:12

    Topics: Animals; Brain; Clonazepam; Disease Models, Animal; Electroencephalography; Epilepsy; Humans; Kindli

1984
Visually-induced seizures.
    Progress in neurobiology, 1980, Volume: 15, Issue:2

    Topics: Corpus Callosum; Electroencephalography; Epilepsy; Geniculate Bodies; Humans; Light; Models, Neurolo

1980
Pharmacological principles in the long-term treatment of epilepsy.
    European neurology, 1981, Volume: 20, Issue:4

    Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Epilepsy; Ethosuximide; Humans; Kinetics; Long

1981
The epileptic mother and her child.
    Epilepsia, 1982, Volume: 23, Issue:1

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Breast Feeding; Carbamazepine; Epilepsy; Female; Fetal

1982
Recent developments in the diagnosis and therapy of epilepsy.
    Annals of internal medicine, 1982, Volume: 97, Issue:4

    Topics: Anticonvulsants; Biofeedback, Psychology; Carbamazepine; Clonazepam; Clorazepate Dipotassium; Condit

1982
Controlled trials in epilepsy: a review.
    Epilepsia, 1982, Volume: 23, Issue:5

    Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Carbamazepine; Clinical Trials as Topic; Double-Blin

1982
Use of antiepileptic drugs in the presence of liver and kidney diseases: a review.
    Epilepsia, 1982, Volume: 23 Suppl 1

    Topics: Anticonvulsants; Carbamazepine; Epilepsy; Half-Life; Humans; Kidney Diseases; Kinetics; Liver Diseas

1982
Therapeutic monitoring of valproic acid.
    Therapeutic drug monitoring, 1980, Volume: 2, Issue:1

    Topics: Aging; Animals; Autoradiography; Drug Evaluation; Drug Interactions; Epilepsy; Half-Life; Humans; Ki

1980
Status epilepticus.
    Neurologic clinics, 1995, Volume: 13, Issue:3

    Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Brain; Electroencephalography; Epilepsy; Female; Hum

1995
Valproic acid. A reappraisal of its pharmacological properties and clinical efficacy in epilepsy.
    Drugs, 1994, Volume: 47, Issue:2

    Topics: Adult; Aged; Aging; Animals; Anticonvulsants; Child; Clinical Trials as Topic; Drug Interactions; El

1994
Mechanisms of action of currently prescribed and newly developed antiepileptic drugs.
    Epilepsia, 1994, Volume: 35 Suppl 4

    Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Drugs, Investigational; Epi

1994
Pregnancy, teratogenesis, and epilepsy.
    Neurologic clinics, 1994, Volume: 12, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Epilepsy; Female; Fetus; Humans; Infant, Newb

1994
The involvement of taurine in the action mechanism of sodium valproate (VPA) in the treatment of epilepsy.
    Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia, 1993, Volume: 43, Issue:1-2

    Topics: Brain; Epilepsy; Humans; Taurine; Valproic Acid

1993
Can we develop improved derivatives of valproic acid?
    Pharmacy world & science : PWS, 1994, Feb-18, Volume: 16, Issue:1

    Topics: Animals; Anticonvulsants; Biotransformation; Drug Evaluation, Preclinical; Epilepsy; Fatty Acids, Mo

1994
Standard approach to antiepileptic drug treatment in the United States.
    Epilepsia, 1994, Volume: 35 Suppl 4

    Topics: Adult; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Drug Administration Schedule; Drug Th

1994
Standard approach to antiepileptic drug treatment in the United Kingdom.
    Epilepsia, 1994, Volume: 35 Suppl 4

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Administration Schedule; Drug Monitor

1994
Handling seizure data: special problems.
    Epilepsy research. Supplement, 1993, Volume: 10

    Topics: Anticonvulsants; Clinical Trials as Topic; Data Interpretation, Statistical; Drug Therapy, Combinati

1993
Pharmacologic intervention and treatment of childhood seizure disorders: relative efficacy and safety of antiepileptic drugs.
    Epilepsia, 1994, Volume: 35 Suppl 2

    Topics: Animals; Anticonvulsants; Carbamazepine; Child; Clinical Trials as Topic; Drug Administration Schedu

1994
[Contribution of new drugs to the better control of epilepsy].
    Anales espanoles de pediatria, 1993, Volume: 39 Suppl 55

    Topics: Aminocaproates; Anticonvulsants; Child; Delayed-Action Preparations; Epilepsy; Felbamate; Humans; Ph

1993
[A case of acute pancreatitis during administration of valproic acid].
    No to hattatsu = Brain and development, 1993, Volume: 25, Issue:5

    Topics: Acute Disease; Adolescent; Epilepsy; Humans; Male; Pancreatitis; Valproic Acid

1993
Clinical pharmacokinetics of antiepileptic drugs in paediatric patients. Part I: Phenobarbital, primidone, valproic acid, ethosuximide and mesuximide.
    Clinical pharmacokinetics, 1995, Volume: 29, Issue:4

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Ethosuximide; Humans; Infant; Infant

1995
Carnitine deficiency in epilepsy: Risk factors and treatment.
    Journal of child neurology, 1995, Volume: 10 Suppl 2

    Topics: Carnitine; Epilepsy; Humans; Liver; Risk Factors; Valproic Acid; Vitamin B Deficiency

1995
A case of esophageal perforation due to a pill-induced ulcer successfully treated with conservative measures.
    The American journal of gastroenterology, 1996, Volume: 91, Issue:5

    Topics: Epilepsy; Esophageal Diseases; Esophageal Perforation; Humans; Male; Middle Aged; Tablets; Ulcer; Va

1996
Drug interaction profile of topiramate.
    Epilepsia, 1996, Volume: 37 Suppl 2

    Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Epile

1996
Interactions of valproic acid with carbamazepine and its metabolites' concentrations, concentrations ratios, and level/dose ratios in epileptic children.
    Clinical neuropharmacology, 1995, Volume: 18, Issue:1

    Topics: Carbamazepine; Child; Drug Interactions; Epilepsy; Female; Humans; Linear Models; Male; Valproic Aci

1995
Mechanisms of action of antiepileptic drugs.
    Seizure, 1995, Volume: 4, Issue:4

    Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; GABA Antagonists; Gabapent

1995
Antiepileptic drug mechanisms of action.
    Epilepsia, 1995, Volume: 36 Suppl 2

    Topics: Acetates; Action Potentials; Amines; Animals; Anticonvulsants; Barbiturates; Benzodiazepines; Calciu

1995
Altered cognitive functioning in children with idiopathic epilepsy receiving valproate monotherapy.
    Journal of child neurology, 1996, Volume: 11, Issue:4

    Topics: Anticonvulsants; Child; Clinical Trials as Topic; Cognition; Epilepsy; Humans; Multicenter Studies a

1996
Antiepileptic drugs--current use.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1996, Volume: 23, Issue:4 Suppl 2

    Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Phenytoin; Valproic Acid

1996
[Advantages and disadvantages of new antiepileptic drugs].
    Revista de neurologia, 1996, Volume: 24, Issue:135

    Topics: Acetates; Adrenocorticotropic Hormone; Amines; Anticonvulsants; Brain; Cyclohexanecarboxylic Acids;

1996
Established antiepileptic drugs.
    Bailliere's clinical neurology, 1996, Volume: 5, Issue:4

    Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Carbamazepine; Epilepsy; Humans; Phenytoin; Succinim

1996
New drug therapy for acute seizure management.
    Seminars in pediatric neurology, 1997, Volume: 4, Issue:1

    Topics: Acute Disease; Anticonvulsants; Child; Diazepam; Epilepsy; Humans; Phenytoin; Prodrugs; Seizures; Va

1997
Adverse effects in epilepsy therapy. Wait and see or go for it?
    Acta neurologica Scandinavica, 1997, Volume: 95, Issue:4

    Topics: Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Epilepsy; Humans; MEDLINE; Valproic Acid

1997
Pharmacologic and dietary therapies in epilepsy: conventional treatments and recent advances.
    Southern medical journal, 1997, Volume: 90, Issue:5

    Topics: Acetates; Amines; Anticonvulsants; Benzodiazepines; Carbamazepine; Cyclohexanecarboxylic Acids; Epil

1997
Pharmacokinetic interactions with felbamate. In vitro-in vivo correlation.
    Clinical pharmacokinetics, 1997, Volume: 33, Issue:3

    Topics: Anticonvulsants; Area Under Curve; Carbamazepine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-4

1997
Adult experience with lamotrigine.
    Journal of child neurology, 1997, Volume: 12 Suppl 1

    Topics: Adult; Anticonvulsants; Drug Interactions; Epilepsy; Humans; Lamotrigine; Treatment Outcome; Triazin

1997
Overview of lamotrigine and the new antiepileptic drugs: the challenge.
    Journal of child neurology, 1997, Volume: 12 Suppl 1

    Topics: Acetates; Amines; Anticonvulsants; Child; Cyclohexanecarboxylic Acids; Drug Interactions; Epilepsy;

1997
[Valproate induced parkinsonism].
    No to shinkei = Brain and nerve, 1998, Volume: 50, Issue:1

    Topics: Aged; Anticonvulsants; Epilepsy; Female; Humans; Male; Parkinson Disease, Secondary; Valproic Acid

1998
Advances in the medical treatment of epilepsy.
    Annual review of medicine, 1998, Volume: 49

    Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Diazepam; Drug Approv

1998
Features and management of poisoning with modern drugs used to treat epilepsy.
    QJM : monthly journal of the Association of Physicians, 1998, Volume: 91, Issue:5

    Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Phenytoin; Valproic Acid

1998
Lamotrigine-induced severe cutaneous adverse reactions.
    Epilepsia, 1998, Volume: 39 Suppl 7

    Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combin

1998
Fortnightly review: drug treatment of epilepsy.
    BMJ (Clinical research ed.), 1999, Jan-09, Volume: 318, Issue:7176

    Topics: Acetates; Amines; Anti-Anxiety Agents; Anticonvulsants; Barbiturates; Benzodiazepines; Clobazam; Clo

1999
Valproate in the treatment of epilepsy in people with intellectual disability.
    Journal of intellectual disability research : JIDR, 1998, Volume: 42 Suppl 1

    Topics: Anticonvulsants; Epilepsy; Humans; Intellectual Disability; Treatment Outcome; Valproic Acid

1998
Options after the first antiepileptic drug has failed.
    Epilepsia, 1999, Volume: 40 Suppl 6

    Topics: Acetates; Amines; Anticonvulsants; Attitude to Health; Carbamazepine; Clinical Trials as Topic; Cycl

1999
Monostars: an aid to choosing an antiepileptic drug as monotherapy.
    Epilepsia, 1999, Volume: 40 Suppl 6

    Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Administration S

1999
Lamotrigine.
    Epilepsia, 1999, Volume: 40 Suppl 5

    Topics: Adolescent; Adult; Animals; Anticonvulsants; Child; Clinical Trials as Topic; Diplopia; Dizziness; D

1999
Is valproate pharmacotherapy associated with polycystic ovaries?
    The Annals of pharmacotherapy, 1999, Volume: 33, Issue:11

    Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; Female; Humans; Ovarian Cysts; Valproic Acid

1999
[Photogenic epilepsy].
    Revista de neurologia, 2000, Volume: 30 Suppl 1

    Topics: Adolescent; Adult; Animals; Anticonvulsants; Child; Child, Preschool; Electroencephalography; Epilep

2000
Carbamazepine versus valproate monotherapy for epilepsy.
    The Cochrane database of systematic reviews, 2000, Issue:3

    Topics: Adult; Anticonvulsants; Carbamazepine; Child; Confidence Intervals; Epilepsy; Humans; Outcome Assess

2000
Is generic prescribing acceptable in epilepsy?
    Drug safety, 2000, Volume: 23, Issue:3

    Topics: Anticonvulsants; Area Under Curve; Biological Availability; Carbamazepine; Chemistry, Pharmaceutical

2000
Idiosyncratic reactions: new methods of identifying high-risk patients.
    Epilepsia, 2000, Volume: 41 Suppl 8

    Topics: Anticonvulsants; Biomarkers; Drug Monitoring; Epilepsy; Epoxide Hydrolases; Felbamate; Free Radical

2000
Therapeutic safety monitoring: what to look for and when to look for it.
    Epilepsia, 2000, Volume: 41 Suppl 8

    Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Monitoring; Epil

2000
New antiepileptic drugs and preparations.
    Emergency medicine clinics of North America, 2000, Volume: 18, Issue:4

    Topics: Acetates; Administration, Rectal; Age Factors; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids;

2000
Valproic acid embryopathy: report of two siblings with further expansion of the phenotypic abnormalities and a review of the literature.
    American journal of medical genetics, 2001, Jan-15, Volume: 98, Issue:2

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anticonvulsants; Epilepsy; Face; Female

2001
[Febrile convulsions, Treatment and prognosis].
    Ugeskrift for laeger, 2001, Feb-19, Volume: 163, Issue:8

    Topics: Analgesics, Non-Narcotic; Anticonvulsants; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Phe

2001
Epilepsy therapy: issues for women and men.
    Current opinion in neurology, 2001, Volume: 14, Issue:2

    Topics: Anticonvulsants; Congenital Abnormalities; Epilepsy; Epilepsy, Temporal Lobe; Female; Humans; Infert

2001
[Studies of damaged processes in the nervous system and possibilities of neuroprotection].
    Przeglad lekarski, 2001, Volume: 58 Suppl 1

    Topics: Adult; Animals; Biomarkers; Calcium Channel Blockers; Child; Epilepsy; Evoked Potentials; Humans; Li

2001
Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials.
    Epilepsia, 2001, Volume: 42, Issue:4

    Topics: Anticonvulsants; Brain Diseases; Brain Injuries; Carbamazepine; Controlled Clinical Trials as Topic;

2001
On the association between valproate and polycystic ovary syndrome.
    Epilepsia, 2001, Volume: 42, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Comorbidity; Epilepsy; Female; Humans; Hyperinsulinism; Insulin

2001
On the association between valproate and polycystic ovary syndrome: a response and an alternative view.
    Epilepsia, 2001, Volume: 42, Issue:3

    Topics: Adolescent; Adult; Animals; Anticonvulsants; Child; Comorbidity; Epilepsy; Female; Fertility; Humans

2001
Polycystic ovarian syndrome--relationship to epilepsy and antiepileptic drug therapy.
    The Journal of clinical endocrinology and metabolism, 2001, Volume: 86, Issue:7

    Topics: Anticonvulsants; Epilepsy; Female; Humans; Polycystic Ovary Syndrome; Risk Factors; Valproic Acid

2001
Cognitive side effects of anticonvulsants.
    The Journal of clinical psychiatry, 2001, Volume: 62 Suppl 14

    Topics: Acetates; Amines; Anticonvulsants; Bipolar Disorder; Carbamazepine; Cognition Disorders; Cyclohexane

2001
Treatment of epilepsy in 3 specialized populations.
    The American journal of managed care, 2001, Volume: 7, Issue:7 Suppl

    Topics: Age Factors; Aged; Anticonvulsants; Carbamazepine; Child; Drug Interactions; Epilepsy; Female; Human

2001
The management of refractory idiopathic epilepsies.
    Epilepsia, 2001, Volume: 42 Suppl 3

    Topics: Adolescent; Anticonvulsants; Child; Clinical Protocols; Drug Administration Schedule; Drug Therapy,

2001
Polycystic ovarian syndrome in women with epilepsy: a review.
    Epilepsia, 2001, Volume: 42 Suppl 3

    Topics: Adult; Anticonvulsants; Comorbidity; Epilepsy; Female; Finland; Follicle Stimulating Hormone; German

2001
New antiepileptic drugs currently in clinical trials: is there a strategy in their development?
    Therapeutic drug monitoring, 2002, Volume: 24, Issue:1

    Topics: Anticonvulsants; Clinical Trials as Topic; Drug Design; Epilepsy; Humans; Valproic Acid

2002
Tubulo-interstitial nephritis caused by sodium valproate.
    Brain & development, 2002, Volume: 24, Issue:2

    Topics: Adolescent; Anticonvulsants; Biopsy; Epilepsy; Fanconi Syndrome; Female; Humans; Nephritis, Intersti

2002
Carbamazepine versus valproate monotherapy for epilepsy: a meta-analysis.
    Epilepsia, 2002, Volume: 43, Issue:5

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female;

2002
Children versus adults: pharmacokinetic and adverse-effect differences.
    Epilepsia, 2002, Volume: 43 Suppl 3

    Topics: Adolescent; Age Factors; Anticonvulsants; Chemical and Drug Induced Liver Injury; Child; Child, Pres

2002
[Pharmacotherapy of epilepsy. II].
    Die Medizinische Welt, 1978, Jun-02, Volume: 29, Issue:22

    Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Benzodiazepines; Carbamazepin

1978
[Long-term anticonvulsant therapy (author's transl)].
    Der Nervenarzt, 1978, Volume: 49, Issue:9

    Topics: Anticonvulsants; Carbamazepine; Chronic Disease; Clonazepam; Epilepsy; Ethosuximide; Humans; Long-Te

1978
Valproic acid. Review of a new antiepileptic drug.
    Archives of neurology, 1979, Volume: 36, Issue:7

    Topics: Adolescent; Adult; Animals; Brain Chemistry; Drug Interactions; Electric Stimulation; Electroencepha

1979
The medical treatment of epilepsy: initiation of drug therapy.
    Pediatric annals, 1979, Volume: 8, Issue:4

    Topics: Adolescent; Adrenocorticotropic Hormone; Anticonvulsants; Bromides; Carbamazepine; Child; Child, Pre

1979
[Valproic acid in the treatment of epilepsy with special emphasis on serum level determination (author's transl)].
    Fortschritte der Neurologie, Psychiatrie, und ihrer Grenzgebiete, 1978, Volume: 46, Issue:6

    Topics: Blood Platelets; Drug Interactions; Electroencephalography; Epilepsy; Fatigue; Half-Life; Humans; Ph

1978
Sodium valproate: a review of its pharmacological properties and therapeutic efficacy in epilepsy.
    Drugs, 1977, Volume: 13, Issue:2

    Topics: Administration, Oral; Adult; Animals; Anticonvulsants; Behavior; Blood Platelets; Child; Clinical Tr

1977
Pharmacological prophylaxis in the kindling model of epilepsy.
    Archives of neurology, 1977, Volume: 34, Issue:7

    Topics: Amygdala; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Atropine; Aziridines; Carba

1977
Sodium di-N-propylacetate (DPA) in the treatment of epilepsy. A review.
    Epilepsia, 1975, Volume: 16, Issue:4

    Topics: Adolescent; Adult; Age Factors; Animals; Cerebral Cortex; Child; Child, Preschool; Drug Evaluation;

1975
[Valproic acid and pregnancy: an unresolved problem. A clinical case].
    Revista chilena de obstetricia y ginecologia, 1992, Volume: 57, Issue:6

    Topics: Abnormalities, Drug-Induced; Adolescent; Cesarean Section; Epilepsy; Female; Humans; Infant, Newborn

1992
Metabolism of antiepileptic medication: newborn to elderly.
    Epilepsia, 1992, Volume: 33 Suppl 4

    Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Carbamazepine; Child; Dose-Response Relations

1992
Problems in the assessment of cognitive effects of antiepileptic drugs.
    Epilepsia, 1992, Volume: 33 Suppl 6

    Topics: Anticonvulsants; Cognition; Cognition Disorders; Epilepsy; Humans; Neuropsychological Tests; Researc

1992
Antiepileptic drugs and their psychotropic effects.
    Epilepsia, 1992, Volume: 33 Suppl 6

    Topics: Affect; Anticonvulsants; Brain; Carbamazepine; Clonazepam; Epilepsy; Humans; Mental Disorders; Psych

1992
Pharmacokinetic evaluation of sustained release formulations of antiepileptic drugs. Clinical implications.
    Clinical pharmacokinetics, 1992, Volume: 22, Issue:1

    Topics: Absorption; Biological Availability; Carbamazepine; Delayed-Action Preparations; Epilepsy; Half-Life

1992
[Acute pancreatitis and valproic acid].
    Pediatrie, 1991, Volume: 46, Issue:12

    Topics: Acute Disease; Child; Epilepsy; Humans; Male; Pancreatitis; Valproic Acid

1991
Routine laboratory monitoring for serious adverse effects of antiepileptic medications: the controversy.
    Epilepsia, 1991, Volume: 32 Suppl 5

    Topics: Anemia, Aplastic; Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury; Drug Monit

1991
Antiepileptic drugs for children: carbamazepine and valproic acid derivatives.
    The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses, 1991, Volume: 23, Issue:2

    Topics: Carbamazepine; Child; Electroencephalography; Epilepsy; Humans; Valproic Acid

1991
Prescribing in epilepsy.
    The Practitioner, 1990, Volume: 234, Issue:1497

    Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Drug Interactions; Epilepsy; Humans; V

1990
The newer antiepileptic drugs: carbamazepine and valproic acid.
    Pediatric annals, 1991, Volume: 20, Issue:1

    Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Interactions; Epilepsy; Humans; Infant

1991
Valproate toxicity: risk-screening strategies.
    Journal of child neurology, 1991, Volume: 6, Issue:1

    Topics: Carnitine; Chemical and Drug Induced Liver Injury; Child; Enzymes; Epilepsy; Hepatic Encephalopathy;

1991
Carnitine, valproate, and toxicity.
    Journal of child neurology, 1991, Volume: 6, Issue:1

    Topics: Carnitine; Chemical and Drug Induced Liver Injury; Child; Epilepsy; Hepatic Encephalopathy; Humans;

1991
Carnitine, valproate, and toxicity.
    Journal of child neurology, 1991, Volume: 6, Issue:1

    Topics: Carnitine; Chemical and Drug Induced Liver Injury; Child; Epilepsy; Hepatic Encephalopathy; Humans;

1991
Carnitine, valproate, and toxicity.
    Journal of child neurology, 1991, Volume: 6, Issue:1

    Topics: Carnitine; Chemical and Drug Induced Liver Injury; Child; Epilepsy; Hepatic Encephalopathy; Humans;

1991
Carnitine, valproate, and toxicity.
    Journal of child neurology, 1991, Volume: 6, Issue:1

    Topics: Carnitine; Chemical and Drug Induced Liver Injury; Child; Epilepsy; Hepatic Encephalopathy; Humans;

1991
Carnitine, valproate, and toxicity.
    Journal of child neurology, 1991, Volume: 6, Issue:1

    Topics: Carnitine; Chemical and Drug Induced Liver Injury; Child; Epilepsy; Hepatic Encephalopathy; Humans;

1991
Carnitine, valproate, and toxicity.
    Journal of child neurology, 1991, Volume: 6, Issue:1

    Topics: Carnitine; Chemical and Drug Induced Liver Injury; Child; Epilepsy; Hepatic Encephalopathy; Humans;

1991
Carnitine, valproate, and toxicity.
    Journal of child neurology, 1991, Volume: 6, Issue:1

    Topics: Carnitine; Chemical and Drug Induced Liver Injury; Child; Epilepsy; Hepatic Encephalopathy; Humans;

1991
Carnitine, valproate, and toxicity.
    Journal of child neurology, 1991, Volume: 6, Issue:1

    Topics: Carnitine; Chemical and Drug Induced Liver Injury; Child; Epilepsy; Hepatic Encephalopathy; Humans;

1991
Carnitine, valproate, and toxicity.
    Journal of child neurology, 1991, Volume: 6, Issue:1

    Topics: Carnitine; Chemical and Drug Induced Liver Injury; Child; Epilepsy; Hepatic Encephalopathy; Humans;

1991
Antiepileptic drugs in affective illness. Clinical and theoretical implications.
    Advances in neurology, 1991, Volume: 55

    Topics: Acute Disease; Anticonvulsants; Benzodiazepines; Bipolar Disorder; Carbamazepine; Depression; Drug T

1991
[Acute fatal liver insufficiency due to valproic acid therapy].
    Schweizerische medizinische Wochenschrift, 1991, Feb-16, Volume: 121, Issue:7

    Topics: Adult; Chemical and Drug Induced Liver Injury; Epilepsy; Hepatic Encephalopathy; Humans; Liver; Male

1991
Valproate: an update--the challenge of modern pediatric seizure management.
    Current problems in pediatrics, 1990, Volume: 20, Issue:4

    Topics: Adolescent; Child; Epilepsy; Humans; Valproic Acid

1990
Antiepileptic drugs, cognitive function, and behavior in children: evidence from recent studies.
    Epilepsia, 1990, Volume: 31 Suppl 4

    Topics: Adult; Age Factors; Anticonvulsants; Carbamazepine; Child; Cognition; Cognition Disorders; Epilepsy;

1990
[Late diagnosis of congenital argininemia during administration of sodium valproate].
    Revue neurologique, 1990, Volume: 146, Issue:12

    Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Ammonia; Arginine; Epilepsy; Female; Humans; Psych

1990
The scope and use of valproate in epilepsy.
    The Journal of clinical psychiatry, 1989, Volume: 50 Suppl

    Topics: Epilepsy; Humans; Valproic Acid

1989
[Fetal disease caused by sodium valproate. Apropos of a case].
    Archives francaises de pediatrie, 1989, Volume: 46, Issue:1

    Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complic

1989
[Valproate dosage].
    Psychiatrie, Neurologie, und medizinische Psychologie, 1989, Volume: 41, Issue:3

    Topics: Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Epilepsy; Humans; Valproic

1989
The neuropharmacology of epileptic falling spells.
    Clinical neuropharmacology, 1987, Volume: 10, Issue:3

    Topics: Anti-Anxiety Agents; Benzodiazepines; Brain; Electroencephalography; Epilepsy; Ethosuximide; Humans;

1987
Sodium valproate.
    Lancet (London, England), 1988, Nov-26, Volume: 2, Issue:8622

    Topics: Epilepsy; Humans; Liver; Valproic Acid

1988
Valproate: an updated review.
    Acta neurologica Scandinavica, 1985, Volume: 72, Issue:2

    Topics: Abnormalities, Drug-Induced; Brain Diseases; Chemical and Drug Induced Liver Injury; Coma; Dyskinesi

1985
[GABAergic theory of epilepsy].
    La Revue du praticien, 1986, Jan-21, Volume: 36, Issue:5

    Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Brain; Dogs; E

1986
Epilepsy and the blood-brain barrier.
    Advances in neurology, 1986, Volume: 44

    Topics: Animals; Animals, Newborn; Anticonvulsants; Biological Transport; Biomechanical Phenomena; Blood Pro

1986
Use of ethosuximide and valproate in the treatment of epilepsy.
    Neurologic clinics, 1986, Volume: 4, Issue:3

    Topics: Abnormalities, Drug-Induced; Brain Diseases; Drug Interactions; Epilepsies, Myoclonic; Epilepsies, P

1986
Antiepileptic drugs in adolescents.
    Journal of adolescent health care : official publication of the Society for Adolescent Medicine, 1987, Volume: 8, Issue:1

    Topics: Adaptation, Psychological; Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Dru

1987
New anticonvulsants in pediatrics: carbamazepine and valproate.
    Current problems in pediatrics, 1987, Volume: 17, Issue:3

    Topics: Adolescent; Carbamazepine; Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Humans

1987
Mechanisms of anticonvulsant drug action. II. Drugs primarily used for absence epilepsy.
    European journal of pediatrics, 1987, Volume: 146, Issue:1

    Topics: Anticonvulsants; Benzodiazepines; Epilepsy; Ethosuximide; Humans; Kinetics; Valproic Acid

1987
Teratogen update: valproic acid.
    Teratology, 1987, Volume: 35, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Epidemiologic Methods; Epilepsy; Female; Humans; Infant, Newbo

1987
Congenital malformations associated with maternal use of valproic acid.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1987, Volume: 14, Issue:3

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Bone and Bones; Epilepsy; Facial Bones; Female

1987
Febrile seizures.
    Emergency medicine clinics of North America, 1987, Volume: 5, Issue:4

    Topics: Child; Child, Preschool; Diagnosis, Differential; Diazepam; Electroencephalography; Epilepsy; Female

1987
Valproate monotherapy in the management of generalized and partial seizures.
    Epilepsia, 1987, Volume: 28 Suppl 2

    Topics: Clinical Trials as Topic; Epilepsies, Partial; Epilepsy; Follow-Up Studies; Humans; Remission Induct

1987
Valproate toxicity.
    Developmental medicine and child neurology, 1988, Volume: 30, Issue:1

    Topics: Child; Epilepsy; Humans; Valproic Acid

1988
[Thyroid function in children under prolonged anticonvulsant therapy].
    Orvosi hetilap, 1988, Jun-05, Volume: 129, Issue:23

    Topics: Anticonvulsants; Carbamazepine; Child; Epilepsy; Ethosuximide; Humans; Secretory Rate; Thyroid Gland

1988
Three cases of delivery under sodium valproate--placental transfer, milk transfer and probable teratogenicity of sodium valproate.
    The Japanese journal of psychiatry and neurology, 1988, Volume: 42, Issue:1

    Topics: Abnormalities, Drug-Induced; Adult; Epilepsy; Female; Fingers; Humans; Infant, Newborn; Male; Matern

1988
Drug treatment of epilepsy.
    Seminars in neurology, 1987, Volume: 7, Issue:2

    Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Ethosuximide; Humans; Ph

1987
Comparison of monotherapy with valproate and other antiepileptic drugs in the treatment of seizure disorders.
    The American journal of medicine, 1988, Jan-25, Volume: 84, Issue:1A

    Topics: Anticonvulsants; Epilepsies, Myoclonic; Epilepsies, Partial; Epilepsy; Humans; Valproic Acid

1988
Review of valproate monotherapy in the treatment of generalized tonic-clonic seizures.
    The American journal of medicine, 1988, Jan-25, Volume: 84, Issue:1A

    Topics: Anticonvulsants; Epilepsy; Humans; Valproic Acid

1988
Pharmacokinetics of anti-epileptic drugs in the dog: a review.
    Journal of veterinary pharmacology and therapeutics, 1985, Volume: 8, Issue:3

    Topics: Animals; Anticonvulsants; Blood Proteins; Carbamazepine; Clonazepam; Diazepam; Dog Diseases; Dogs; E

1985

Trials

260 trials available for valproic acid and Aura

ArticleYear
Lamotrigine versus levetiracetam or zonisamide for focal epilepsy and valproate versus levetiracetam for generalised and unclassified epilepsy: two SANAD II non-inferiority RCTs.
    Health technology assessment (Winchester, England), 2021, Volume: 25, Issue:75

    Topics: Child, Preschool; Cost-Benefit Analysis; Epilepsies, Partial; Epilepsy; Female; Humans; Lamotrigine;

2021
Effect of Daily Vitamin D Supplementation on Serum Vitamin D Levels in Children with Epilepsy Receiving Sodium Valproate Monotherapy: A Randomized, Controlled Trial.
    Indian journal of pediatrics, 2023, Volume: 90, Issue:5

    Topics: Alkaline Phosphatase; Calcium; Child; Dietary Supplements; Epilepsy; Humans; Parathyroid Hormone; Ph

2023
Value of Group Intervention on Prognosis of Quality of Life in Epileptic Patients Treated With Sodium Valproate and Lamotrigine.
    Alternative therapies in health and medicine, 2023, Volume: 29, Issue:3

    Topics: Epilepsy; Humans; Lamotrigine; Prognosis; Quality of Life; Valproic Acid

2023
Population pharmacokinetics and exposure-safety of lipophilic conjugates prodrug DP-VPA in healthy Chinese subjects for dose regime exploring.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2023, Volume: 188

    Topics: Drug-Related Side Effects and Adverse Reactions; East Asian People; Epilepsy; Healthy Volunteers; Hu

2023
Cross-sectional evaluation of prescription of valproate and other antiepileptic drugs to pregnant women.
    Acta neurologica Belgica, 2021, Volume: 121, Issue:2

    Topics: Anticonvulsants; Cross-Sectional Studies; Drug Prescriptions; Epilepsy; Female; Humans; Infant, Newb

2021
Multi-drug therapy for epilepsy influenced bispectral index after a bolus propofol administration without affecting propofol's pharmacokinetics: a prospective cohort study.
    Scientific reports, 2020, 01-31, Volume: 10, Issue:1

    Topics: Adult; Anesthesia, General; Anticonvulsants; Consciousness Monitors; Drug Interactions; Drug Therapy

2020
A Phase II Randomized Trial to Explore the Potential for Pharmacokinetic Drug-Drug Interactions with Stiripentol or Valproate when Combined with Cannabidiol in Patients with Epilepsy.
    CNS drugs, 2020, Volume: 34, Issue:6

    Topics: Adolescent; Adult; Anticonvulsants; Area Under Curve; Cannabidiol; Dioxolanes; Dose-Response Relatio

2020
Evaluate the effects of long-term valproic acid treatment on metabolic profiles in newly diagnosed or untreated female epileptic patients: A prospective study.
    Seizure, 2017, Volume: 48

    Topics: Adiponectin; Adolescent; Adult; Anticonvulsants; Blood Glucose; Body Mass Index; Cholesterol; Choles

2017
An investigation on the effects of carbamazepine and sodium valproate on neuromuscular transmission.
    Acta neurologica Belgica, 2020, Volume: 120, Issue:3

    Topics: Adult; Anticonvulsants; Carbamazepine; Electromyography; Epilepsy; Female; Humans; Male; Synaptic Tr

2020
Evaluate the effects of antiepileptic drugs on reproductive endocrine system in newly diagnosed female epileptic patients receiving either Valproate or Lamotrigine monotherapy: A prospective study.
    Epilepsy research, 2018, Volume: 139

    Topics: Adolescent; Adult; Anticonvulsants; Endocrine System; Epilepsy; Female; Follow-Up Studies; Hormones;

2018
Unblinded, randomized multicenter trial comparing lamotrigine and valproate combination with controlled-release carbamazepine monotherapy as initial drug regimen in untreated epilepsy.
    Seizure, 2018, Volume: 55

    Topics: Adult; Anticonvulsants; Carbamazepine; Delayed-Action Preparations; Drug Therapy, Combination; Epile

2018
Determinants of free serum valproate concentration: A prospective study in patients on divalproex sodium monotherapy.
    Seizure, 2018, Volume: 59

    Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Child; Dose-Response Relationship, Drug; Doub

2018
Therapeutic drug monitoring of valproic acid.
    Pakistan journal of pharmaceutical sciences, 2018, Volume: 31, Issue:4(Special)

    Topics: Adult; Age Factors; Aged; Anticonvulsants; Child, Preschool; Drug Monitoring; Epilepsy; Female; Huma

2018
Pharmacokinetics of lamotrigine in paediatric and young adult epileptic patients--nonlinear mixed effects modelling approach.
    European journal of clinical pharmacology, 2014, Volume: 70, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Interactions; Drug

2014
Treatment outcome after failure of a first antiepileptic drug.
    Neurology, 2014, Aug-05, Volume: 83, Issue:6

    Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Fructose; Humans; Lamotrigine; Male; Middle Ag

2014
Influence of valproic acid concentration and polymorphism of UGT1A4*3, UGT2B7 -161C > T and UGT2B7*2 on serum concentration of lamotrigine in Chinese epileptic children.
    European journal of clinical pharmacology, 2015, Volume: 71, Issue:11

    Topics: Adolescent; Anticonvulsants; Asian People; Child; Child, Preschool; Drug Therapy, Combination; Epile

2015
Monotherapy with Levetiracetam Versus Older AEDs: A Randomized Comparative Trial of Effects on Bone Health.
    Calcified tissue international, 2016, Volume: 98, Issue:6

    Topics: Absorptiometry, Photon; Adult; Aged; Anticonvulsants; Bone and Bones; Bone Density; Bone Remodeling;

2016
Carnitine and/or Acetylcarnitine Deficiency as a Cause of Higher Levels of Ammonia.
    BioMed research international, 2016, Volume: 2016

    Topics: Acetylcarnitine; Adolescent; Adult; Aged; Aged, 80 and over; Ammonia; Bipolar Disorder; Carnitine; E

2016
Valproate effect on ketosis in children under ketogenic diet.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2016, Volume: 20, Issue:4

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Combined Modality Therapy; Diet, Ketogenic; Ep

2016
Comparative effectiveness of levetiracetam, valproate and carbamazepine among elderly patients with newly diagnosed epilepsy: subgroup analysis of the randomized, unblinded KOMET study.
    BMC neurology, 2016, Aug-23, Volume: 16, Issue:1

    Topics: Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Levetiracetam; Ma

2016
Association of UGT2B7 and UGT1A4 Polymorphisms with Serum Concentration of Antiepileptic Drugs in Children.
    Medical science monitor : international medical journal of experimental and clinical research, 2016, Oct-31, Volume: 22

    Topics: Adolescent; Anticonvulsants; Asian People; Base Sequence; Child; Child, Preschool; Epilepsy; Female;

2016
Pharmacokinetic interaction of brivaracetam on carbamazepine in adult patients with epilepsy, with and without valproate co-administration.
    Epilepsy research, 2016, Volume: 128

    Topics: Adult; Anticonvulsants; Biomarkers; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactio

2016
Phenobarbital Versus Valproate for Generalized Convulsive Status Epilepticus in Adults: A Prospective Randomized Controlled Trial in China.
    CNS drugs, 2016, Volume: 30, Issue:12

    Topics: Administration, Intravenous; Adult; Anticonvulsants; China; Diazepam; Epilepsy; Female; Humans; Male

2016
Brivaracetam population pharmacokinetics in children with epilepsy aged 1 month to 16 years.
    European journal of clinical pharmacology, 2017, Volume: 73, Issue:6

    Topics: Administration, Oral; Adolescent; Age Factors; Anticonvulsants; Carbamazepine; Child; Child, Prescho

2017
Effect of antiepileptic drug polytherapy on urinary pH in children and young adults.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2009, Volume: 25, Issue:2

    Topics: Acetazolamide; Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Ther

2009
Hyperandrogenism, ovulatory dysfunction, and polycystic ovary syndrome with valproate versus lamotrigine.
    Annals of neurology, 2008, Volume: 64, Issue:2

    Topics: Adolescent; Adult; Anovulation; Epilepsy; Female; Humans; Hyperandrogenism; Internationality; Lamotr

2008
Treatment of status epilepticus and acute repetitive seizures with i.v. valproic acid vs phenytoin.
    Acta neurologica Scandinavica, 2008, Volume: 118, Issue:5

    Topics: Acute Disease; Adult; Aged; Anticonvulsants; Brain; Drug-Related Side Effects and Adverse Reactions;

2008
Lipid profile, apolipoproteins A and B in children with epilepsy.
    Journal of child neurology, 2008, Volume: 23, Issue:11

    Topics: Anticonvulsants; Apolipoproteins A; Apolipoproteins B; Carbamazepine; Case-Control Studies; Child; C

2008
Conversion from valproic acid onto topiramate in adolescents and adults with epilepsy.
    Acta neurologica Scandinavica, 2009, Volume: 119, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Child; Dose-Response Relationship, Drug

2009
Serum and muscle carnitine levels in epileptic children receiving sodium valproate.
    Journal of child neurology, 2009, Volume: 24, Issue:1

    Topics: Carnitine; Child; Child, Preschool; Enzyme Inhibitors; Epilepsy; Female; Humans; Male; Muscles; Seru

2009
Seizure control and side-effect profile after switching adult epileptic patients from standard to extended-release divalproex sodium.
    Clinical neurology and neurosurgery, 2009, Volume: 111, Issue:5

    Topics: Activities of Daily Living; Adult; Anticonvulsants; Body Weight; Cohort Studies; Data Interpretation

2009
Hyperammonemia following intravenous valproate loading.
    Epilepsy research, 2009, Volume: 85, Issue:1

    Topics: Adult; Aged; Ammonia; Analysis of Variance; Anticonvulsants; Bilirubin; Dose-Response Relationship,

2009
Effects of valproate or lamotrigine monotherapy on the reproductive endocrine and insulin-related metabolic profile in Chinese adults with epilepsy: a prospective randomized study.
    Epilepsy & behavior : E&B, 2009, Volume: 14, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; China; Cross-Sectional Studies; Dose-Response Relationship, Drug

2009
The risk of asymptomatic hyperammonemia in children with idiopathic epilepsy treated with valproate: relationship to blood carnitine status.
    Epilepsy research, 2009, Volume: 86, Issue:1

    Topics: Adolescent; Ammonia; Anticonvulsants; Carnitine; Child; Epilepsy; Female; Humans; Hyperammonemia; Ma

2009
Effects of valproic acid on sleep in children with epilepsy.
    Epilepsia, 2009, Volume: 50, Issue:8

    Topics: Adolescent; Age Factors; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Infant;

2009
Reversible effects of antiepileptic drugs on thyroid hormones in men and women with epilepsy: a prospective randomized double-blind withdrawal study.
    Epilepsy & behavior : E&B, 2009, Volume: 16, Issue:1

    Topics: Adolescent; Adult; Age of Onset; Aged; Anticonvulsants; Carbamazepine; Double-Blind Method; Epilepsy

2009
The influence of drug-drug interaction and patients' characteristics on valproic acid's clearance in adults with epilepsy using nonlinear mixed effects modeling.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2009, Dec-08, Volume: 38, Issue:5

    Topics: Adult; Drug Interactions; Epilepsy; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Non

2009
Effects of valproate, carbamazepine, and levetiracetam on the antioxidant and oxidant systems in epileptic patients and their clinical importance.
    Clinical neuropharmacology, 2010, Volume: 33, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Antioxidants; Aryldialkylphosphatase; Biomarkers; Carbamazepine;

2010
Somatosensory evoked potentials in epileptic children treated with carbamazepine or valproate in monotherapy - a preliminary study.
    Advances in medical sciences, 2010, Volume: 55, Issue:2

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Evoked Potentials, Somatosensory; Femal

2010
[Comparative efficacy of carbamazepine, valproic acid and topiramate in symptomatic and cryptogenic occipital lobe epilepsy in children].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2010, Volume: 110, Issue:5 Suppl 1

    Topics: Adolescent; Anticonvulsants; Benzodiazepines; Brain Injuries; Carbamazepine; Child; Epilepsies, Part

2010
Effects of epilepsy and antiepileptic drugs on nitric oxide, lipid peroxidation and xanthine oxidase system in children with idiopathic epilepsy.
    Seizure, 2011, Volume: 20, Issue:2

    Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Lipid Peroxidatio

2011
Effects of carbamazepine and metabolites on IL-2, IL-5, IL-6, IL-10 and IFN-γ secretion in epileptic patients: the influence of co-medication.
    Pharmacological reports : PR, 2011, Volume: 63, Issue:1

    Topics: Acridines; Adult; Aged; Anticonvulsants; Carbamazepine; Dibenzazepines; Drug Therapy, Combination; E

2011
Valproate versus diazepam for generalized convulsive status epilepticus: a pilot study.
    European journal of neurology, 2011, Volume: 18, Issue:12

    Topics: Adult; Aged; Anticonvulsants; Cerebrovascular Disorders; Diazepam; Drug Resistance; Electroencephalo

2011
The effect of topiramate monotherapy on bone mineral density and markers of bone and mineral metabolism in premenopausal women with epilepsy.
    Epilepsia, 2011, Volume: 52, Issue:10

    Topics: Adult; Alkaline Phosphatase; Anticonvulsants; Bicarbonates; Bone and Bones; Bone Density; Calcificat

2011
Effects of the abrupt switch from solution to modified-release granule formulation of valproate.
    Acta neurologica Scandinavica, 2012, Volume: 125, Issue:3

    Topics: Anticonvulsants; Chemistry, Pharmaceutical; Child; Child, Preschool; Delayed-Action Preparations; Ep

2012
Long-term control of epileptic drop attacks with the combination of valproate, lamotrigine, and a benzodiazepine: a 'proof of concept,' open label study.
    Epilepsia, 2011, Volume: 52, Issue:7

    Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Drug Therapy, Combinat

2011
[Observation on therapeutic effect of acupoint catgut-embedding combined western medicine for epilepsy of generalized seizures type].
    Zhongguo zhen jiu = Chinese acupuncture & moxibustion, 2011, Volume: 31, Issue:6

    Topics: Acupuncture Points; Acupuncture Therapy; Adolescent; Adult; Anticonvulsants; Catgut; Child; Child, P

2011
Population pharmacokinetics of valproic acid in pediatric patients with epilepsy: considerations for dosing spinal muscular atrophy patients.
    Journal of clinical pharmacology, 2012, Volume: 52, Issue:11

    Topics: Adolescent; Anticonvulsants; Capsules; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Ma

2012
The effect of vitamin B supplementation on homocysteine metabolism and clinical state of patients with chronic epilepsy treated with carbamazepine and valproic acid.
    Seizure, 2012, Volume: 21, Issue:4

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Dietary Supplements; Epilepsy; Female; Foli

2012
Impact of age, weight and concomitant treatment on lamotrigine pharmacokinetics.
    Journal of clinical pharmacy and therapeutics, 2012, Volume: 37, Issue:6

    Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Area Under Curve; Body Weight; Carbamazepine; Child

2012
The effects of oxcarbazepine and valproate therapies on growth in children with epilepsy.
    Endocrine research, 2012, Volume: 37, Issue:4

    Topics: Adolescent; Anticonvulsants; Body Height; Carbamazepine; Child; Child, Preschool; Epilepsy; Female;

2012
Valproate sodium enhances body weight gain in patients with childhood epilepsy: a pathogenic mechanisms and open-label clinical trial of behavior therapy.
    Seizure, 2012, Volume: 21, Issue:7

    Topics: Adolescent; Anticonvulsants; Behavior Therapy; Body Mass Index; Child; Epilepsy; Female; Humans; Hyp

2012
[Efficacy and safety of the combined therapy of valproic acid and lamotrigine for epileptics].
    Zhonghua yi xue za zhi, 2012, May-08, Volume: 92, Issue:17

    Topics: Child; Child, Preschool; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy; Epilepsy, Absence

2012
SCN1A IVS5N+5 polymorphism and response to sodium valproate: a multicenter study.
    Pharmacogenomics, 2012, Volume: 13, Issue:13

    Topics: Adolescent; Adult; Alternative Splicing; Anticonvulsants; Asian People; Child; Cohort Studies; Epile

2012
Outcomes of sustained-release formulation of valproate and topiramate monotherapy in patients with epilepsy: a multi-centre, cohort study.
    PloS one, 2012, Volume: 7, Issue:12

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; China; Cohort Studies; Epilepsy;

2012
Pharmacokinetic and pharmacodynamic effects of clonazepam in children with epilepsy treated with valproate: a preliminary study.
    Therapeutic drug monitoring, 2002, Volume: 24, Issue:4

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Chromatography, Gas; Chromatography, High Pres

2002
Increase in postprandial serum insulin levels in epileptic patients with valproic acid therapy.
    Metabolism: clinical and experimental, 2002, Volume: 51, Issue:10

    Topics: Adult; Anticonvulsants; Blood Glucose; Body Mass Index; Cholesterol; Cholesterol, LDL; Epilepsy; Fem

2002
Safety and tolerance of rapidly infused Depacon. A randomized trial in subjects with epilepsy.
    Epilepsy research, 2003, Volume: 52, Issue:3

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Black People; Blood Pressure; Child; Child, Preschool; Dos

2003
Valproate unbound fraction and distribution volume following rapid infusions in patients with epilepsy.
    Epilepsy research, 2003, Volume: 53, Issue:1-2

    Topics: Adolescent; Adult; Aged; Algorithms; Anticonvulsants; Child; Child, Preschool; Dose-Response Relatio

2003
Fasting serum insulin and lipid levels in men with epilepsy.
    Neurology, 2003, Feb-25, Volume: 60, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Body Mass Index; Carbamazepine; Epilepsy; Fasting; Humans; Hyper

2003
Topiramate, carbamazepine and valproate monotherapy: double-blind comparison in newly diagnosed epilepsy.
    Acta neurologica Scandinavica, 2003, Volume: 107, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Double-Blind M

2003
Lamotrigine versus valproate monotherapy-associated weight change in adolescents with epilepsy: results from a post hoc analysis of a randomized, double-blind clinical trial.
    Journal of child neurology, 2003, Volume: 18, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Anticonvulsants; Body Mass Index; Child; Double-Blind Metho

2003
[Influence of ivadal and depakene chrono on sleep structure in patients with epilepsy].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2003, Volume: 103, Issue:3

    Topics: Adult; Delayed-Action Preparations; Drug Administration Schedule; Electroencephalography; Electroocu

2003
The pharmacokinetics of oxcarbazepine and its active metabolite 10-hydroxy-carbazepine in healthy subjects and in epileptic patients treated with phenobarbitone or valproic acid.
    British journal of clinical pharmacology, 1993, Volume: 36, Issue:4

    Topics: Administration, Oral; Adult; Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy; Female; Ha

1993
Lamotrigine monotherapy compared with carbamazepine, phenytoin, or valproate monotherapy in patients with epilepsy.
    Epilepsy & behavior : E&B, 2003, Volume: 4, Issue:6

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Evaluation

2003
Thyroid function in girls with epilepsy with carbamazepine, oxcarbazepine, or valproate monotherapy and after withdrawal of medication.
    Epilepsia, 2004, Volume: 45, Issue:3

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Cross-Sectional Studies; Drug Administration Sche

2004
Topiramate, carbamazepine, and valproate monotherapy: double-blind comparison in children with newly diagnosed epilepsy.
    Journal of child neurology, 2004, Volume: 19, Issue:2

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Dose-Response Relationship, Drug; Double-Blind Me

2004
The effect of valproate on bone mineral density in adult epileptic patients.
    Pharmacological research, 2004, Volume: 50, Issue:1

    Topics: Absorptiometry, Photon; Adult; Anticonvulsants; Body Mass Index; Bone Density; Epilepsy; Female; Hum

2004
Obesity and plasma concentrations of alpha-tocopherol and beta-carotene in epileptic girls treated with valproate.
    Neuroendocrinology, 2004, Volume: 79, Issue:3

    Topics: Adolescent; alpha-Tocopherol; Anticonvulsants; Antioxidants; beta Carotene; Body Weight; Carotenoids

2004
Reversible parkinsonism with normal beta-CIT-SPECT in patients exposed to sodium valproate.
    Neurology, 2004, Apr-27, Volume: 62, Issue:8

    Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Incidence; Male; Middle Aged;

2004
Add-on melatonin improves quality of life in epileptic children on valproate monotherapy: a randomized, double-blind, placebo-controlled trial.
    Epilepsy & behavior : E&B, 2004, Volume: 5, Issue:3

    Topics: Anticonvulsants; Antioxidants; Child; Child, Preschool; Cross-Over Studies; Dose-Response Relationsh

2004
Efficacy and tolerability of conversion to monotherapy with lamotrigine compared with valproate and carbamazepine in patients with epilepsy.
    Epilepsy & behavior : E&B, 2004, Volume: 5, Issue:4

    Topics: Adult; Anticonvulsants; Carbamazepine; Chi-Square Distribution; Drug Interactions; Drug Tolerance; E

2004
Bone mineral metabolism changes in epileptic children receiving valproic acid.
    Journal of paediatrics and child health, 2004, Volume: 40, Issue:8

    Topics: Absorptiometry, Photon; Adolescent; Alkaline Phosphatase; Anticonvulsants; Bone Density; Bone Diseas

2004
Rapid infusion with valproate sodium is well tolerated in patients with epilepsy.
    Neurology, 2004, Oct-26, Volume: 63, Issue:8

    Topics: Acute Disease; Anticonvulsants; Blood Pressure; Cohort Studies; Dose-Response Relationship, Drug; Dr

2004
Topiramate pharmacokinetics in children with epilepsy aged from 6 months to 4 years.
    Epilepsia, 2004, Volume: 45, Issue:11

    Topics: Age Factors; Anticonvulsants; Area Under Curve; Biological Availability; Child, Preschool; Drug Admi

2004
A randomized, double-blind, placebo controlled trial of melatonin add-on therapy in epileptic children on valproate monotherapy: effect on glutathione peroxidase and glutathione reductase enzymes.
    British journal of clinical pharmacology, 2004, Volume: 58, Issue:5

    Topics: Anticonvulsants; Antioxidants; Child; Child, Preschool; Double-Blind Method; Drug Therapy, Combinati

2004
A dosing algorithm for converting from valproate monotherapy to lamotrigine monotherapy in patients with epilepsy.
    Epilepsy & behavior : E&B, 2005, Volume: 6, Issue:1

    Topics: Adolescent; Adult; Aged; Algorithms; Anticonvulsants; Confidence Intervals; Demography; Dose-Respons

2005
Computerized tremor analysis of valproate-induced tremor: a comparative study of controlled-release versus conventional valproate.
    Epilepsia, 2005, Volume: 46, Issue:2

    Topics: Activities of Daily Living; Adolescent; Adult; Aged; Anticonvulsants; Delayed-Action Preparations; D

2005
Extended-release divalproex in child and adolescent outpatients with epilepsy.
    Epilepsia, 2005, Volume: 46, Issue:3

    Topics: Adolescent; Age Factors; Ambulatory Care; Capsules; Child; Cross-Over Studies; Delayed-Action Prepar

2005
Pharmacological outcomes in newly diagnosed epilepsy.
    Epilepsy & behavior : E&B, 2005, Volume: 6, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, C

2005
Visual function in epilepsy patients treated with initial valproate monotherapy.
    Seizure, 2005, Volume: 14, Issue:6

    Topics: Adult; Aged; Anticonvulsants; Color Perception; Contrast Sensitivity; Epilepsy; Female; Functional L

2005
Successful initiation of combined therapy with valproate sodium injection and divalproex sodium extended-release tablets in the epilepsy monitoring unit.
    Epilepsia, 2005, Volume: 46, Issue:6

    Topics: Administration, Oral; Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Delayed-Act

2005
Effectiveness of lamotrigine in clinical practice: results of a retrospective population-based study.
    Epilepsy research, 2005, Volume: 65, Issue:1-2

    Topics: Adult; Anticonvulsants; Drug Interactions; Epilepsy; Female; Humans; Lamotrigine; Logistic Models; M

2005
Analysis of pregabalin at therapeutic concentrations in human plasma/serum by reversed-phase HPLC.
    Therapeutic drug monitoring, 2005, Volume: 27, Issue:4

    Topics: Anticonvulsants; Calibration; Carbamazepine; Chromatography, High Pressure Liquid; Dose-Response Rel

2005
[Acceptability and tolerance of sodium valproate, a new sustained-action granule formulation, in monotherapy for epileptic children from 3 years old].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2005, Volume: 12, Issue:10

    Topics: Administration, Oral; Adolescent; Anticonvulsants; Child; Child, Preschool; Delayed-Action Preparati

2005
[Valproate sustained release in the treatment of epilepsy].
    Fortschritte der Neurologie-Psychiatrie, 2005, Volume: 73, Issue:11

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Child; Delayed-Action Preparations; Epi

2005
Plasma free carnitine in epilepsy children, adolescents and young adults treated with old and new antiepileptic drugs with or without ketogenic diet.
    Brain & development, 2006, Volume: 28, Issue:6

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Carnitine; Child; Child, Preschool; Dietary Fats;

2006
Serum insulin, leptin, and neuropeptide y levels in epileptic children treated with valproate.
    Journal of child neurology, 2005, Volume: 20, Issue:10

    Topics: Anticonvulsants; Blood Glucose; Body Mass Index; Child; Child, Preschool; Epilepsy; Female; Humans;

2005
Every-12-hour administration of extended-release divalproex in patients with epilepsy: impact on plasma valproic acid concentrations.
    Epilepsy & behavior : E&B, 2006, Volume: 8, Issue:2

    Topics: Adult; Anticonvulsants; Biological Availability; Cross-Over Studies; Delayed-Action Preparations; Dr

2006
Evolution of serum lipids and lipoprotein (a) levels in epileptic children treated with carbamazepine, valproic acid, and phenobarbital.
    Journal of child neurology, 2006, Volume: 21, Issue:1

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Diet; Epilepsy; Female; Humans; Lipids; Lipoprote

2006
Effect of antiepileptic drugs on plasma lipids, lipoprotein (a), and liver enzymes.
    Journal of child neurology, 2006, Volume: 21, Issue:1

    Topics: Adolescent; Alkaline Phosphatase; Anticonvulsants; Apolipoproteins; Carbamazepine; Child; Child, Pre

2006
Conversion from delayed-release sodium valproate to extended-release sodium valproate: initial results and long-term follow-up.
    Epilepsy & behavior : E&B, 2006, Volume: 8, Issue:3

    Topics: Anticonvulsants; Delayed-Action Preparations; Epilepsy; Follow-Up Studies; Humans; Patient Complianc

2006
Add-on lamotrigine treatment and plasma glutamate levels in epilepsy: relation to treatment response.
    Epilepsy research, 2006, Volume: 70, Issue:2-3

    Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Female; Glutamic Acid; Humans; Lamotrig

2006
Quantitative EEG effects of carbamazepine, oxcarbazepine, valproate, lamotrigine, and possible clinical relevance of the findings.
    Epilepsy research, 2006, Volume: 70, Issue:2-3

    Topics: Adolescent; Adult; Alpha Rhythm; Anticonvulsants; Carbamazepine; Child; Electroencephalography; Epil

2006
Early and persistent increase in serum lipoprotein (a) concentrations in epileptic children treated with carbamazepine and sodium valproate monotherapy.
    Epilepsy research, 2006, Volume: 70, Issue:2-3

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Lipid

2006
Color vision and macular recovery time in epileptic adolescents treated with valproate and carbamazepine.
    European journal of neurology, 2006, Volume: 13, Issue:7

    Topics: Adolescent; Analysis of Variance; Anticonvulsants; Carbamazepine; Color Perception; Epilepsy; Female

2006
Effects of anticonvulsant therapy on vitamin D status in children: prospective monitoring study.
    Journal of child neurology, 2006, Volume: 21, Issue:3

    Topics: Anticonvulsants; Calcium; Carbamazepine; Child; Epilepsy; Female; Follow-Up Studies; Humans; Male; P

2006
Valproate effects on kinetics of lamotrigine in pregnancy and treatment with oral contraceptives.
    Neurology, 2006, Oct-10, Volume: 67, Issue:7

    Topics: Anticonvulsants; Contraceptives, Oral; Drug Combinations; Epilepsy; Female; Humans; Kinetics; Lamotr

2006
Efficacy of carbamazepine and valproate as monotherapy for early epilepsy and single seizures.
    Neurology, 2006, Nov-28, Volume: 67, Issue:10

    Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Carbamazepine; Cohort Studies; Drug Administration

2006
Influence of major antiepileptic drugs on attention, reaction time, and speed of information processing: results from a randomized, double-blind, placebo-controlled withdrawal study of seizure-free epilepsy patients receiving monotherapy.
    Epilepsia, 2006, Volume: 47, Issue:12

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Attention; Carbamazepine; Cognition; Cognition Disorders;

2006
Safety of rapid intravenous valproate infusion in pediatric patients.
    Pediatric neurology, 2007, Volume: 36, Issue:2

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Infusions, I

2007
Safety of rapid intravenous loading of valproate.
    Epilepsia, 2007, Volume: 48, Issue:3

    Topics: Adult; Aged; Analysis of Variance; Anticonvulsants; Blood Pressure; Consciousness; Dose-Response Rel

2007
Cognitive side effects of valproic acid-induced hyperammonemia in children with epilepsy.
    Journal of clinical psychopharmacology, 2007, Volume: 27, Issue:2

    Topics: Adolescent; Anticonvulsants; Child; Cognition Disorders; Epilepsy; Female; Humans; Hyperammonemia; M

2007
Inhibitory effect of valproic acid on cytochrome P450 2C9 activity in epilepsy patients.
    Basic & clinical pharmacology & toxicology, 2007, Volume: 100, Issue:6

    Topics: Adolescent; Adult; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liq

2007
The measurement and magnitude of awareness difficulties after traumatic brain injury: a longitudinal study.
    Journal of the International Neuropsychological Society : JINS, 2007, Volume: 13, Issue:4

    Topics: Adult; Anticonvulsants; Awareness; Brain Injuries; Double-Blind Method; Epilepsy; Female; Glasgow Co

2007
Antiepileptic drugs and the significance of event-related potentials.
    Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society, 2007, Volume: 24, Issue:3

    Topics: Adult; Analysis of Variance; Anticonvulsants; Carbamazepine; Case-Control Studies; Electroencephalog

2007
Sodium valproate versus lamotrigine: a randomised comparison of efficacy, tolerability and effects on circulating androgenic hormones in newly diagnosed epilepsy.
    Epilepsy research, 2007, Volume: 75, Issue:2-3

    Topics: Adolescent; Adult; Aged; Androgens; Androstenedione; Anticonvulsants; Body Mass Index; Body Weight;

2007
Reversible effects of antiepileptic drugs on reproductive endocrine function in men and women with epilepsy--a prospective randomized double-blind withdrawal study.
    Epilepsia, 2007, Volume: 48, Issue:10

    Topics: Adolescent; Adult; Aged; Androgens; Anticonvulsants; Carbamazepine; Double-Blind Method; Epilepsy; E

2007
Valproate protein binding following rapid intravenous administration of high doses of valproic acid in patients with epilepsy.
    Journal of clinical pharmacy and therapeutics, 2007, Volume: 32, Issue:4

    Topics: Adult; Age Factors; Aged; Anticonvulsants; Body Weight; Dose-Response Relationship, Drug; Epilepsy;

2007
Lack of pharmacokinetic interaction of levetiracetam on carbamazepine, valproic acid, topiramate, and lamotrigine in children with epilepsy.
    Epilepsia, 2007, Volume: 48, Issue:11

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Interactions; Drug Therapy

2007
A randomised controlled trial examining the longer-term outcomes of standard versus new antiepileptic drugs. The SANAD trial.
    Health technology assessment (Winchester, England), 2007, Volume: 11, Issue:37

    Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsy; Female; Fructo

2007
An observational study of first-line valproate monotherapy in focal epilepsy.
    European journal of neurology, 2008, Volume: 15, Issue:1

    Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Brain Diseases; Child; Delayed-Action Preparations;

2008
Thyroid function and volume in epileptic children using carbamazepine, oxcarbazepine and valproate.
    Pediatrics international : official journal of the Japan Pediatric Society, 2007, Volume: 49, Issue:6

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Hypot

2007
The role of ghrelin in weight gain and growth in epileptic children using valproate.
    Journal of child neurology, 2007, Volume: 22, Issue:12

    Topics: Adolescent; Anticonvulsants; Blood Glucose; Body Height; Body Mass Index; Body Weight; C-Peptide; Ch

2007
Potential relationships between transaminase abnormality and valproic acid clearance or serum carnitine concentrations in Japanese epileptic patients.
    The Journal of pharmacy and pharmacology, 2008, Volume: 60, Issue:2

    Topics: Adolescent; Adult; Ammonia; Anticonvulsants; Body Weight; Carnitine; Chemical and Drug Induced Liver

2008
Attention changes in epilepsy patients following 3-month topiramate or valproate treatment revealed by event-related potential.
    International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 2008, Volume: 68, Issue:3

    Topics: Adolescent; Adult; Attention; Case-Control Studies; Electroencephalography; Epilepsy; Evoked Potenti

2008
Valproate affects reproductive endocrine function, testis diameter and some semen variables in non-epileptic adolescent goat bucks.
    Theriogenology, 2008, Jul-01, Volume: 70, Issue:1

    Topics: Animals; Anticonvulsants; Body Weight; Endocrine System; Epilepsy; Flow Cytometry; Goat Diseases; Go

2008
Effect of valproic acid treatment on body composition, leptin and the soluble leptin receptor in epileptic children.
    Epilepsy research, 2008, Volume: 80, Issue:2-3

    Topics: Adolescent; Anthropology, Physical; Anticonvulsants; Body Composition; Body Mass Index; Child; Cross

2008
Serum concentrations and enzyme induction in epileptic children treated with phenytoin and valproate.
    Neuropediatrics, 1982, Volume: 13, Issue:1

    Topics: Child; Enzyme Induction; Epilepsy; gamma-Glutamyltransferase; Humans; Phenytoin; Valproic Acid

1982
[Anti-epileptic agents during pregnancy. A prospective study on the course of pregnancy, malformations and child development].
    Deutsche medizinische Wochenschrift (1946), 1983, Feb-18, Volume: 108, Issue:7

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Akathisia, Drug-Induced; Anencephaly; Ant

1983
Developments in pharmacotherapy of epilepsy.
    Progress in clinical and biological research, 1983, Volume: 124

    Topics: Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Epilepsy; Humans; Research Design; Valproi

1983
Plasma concentrations of sodium valproate: their clinical value.
    Annals of neurology, 1983, Volume: 14, Issue:1

    Topics: Clinical Trials as Topic; Dose-Response Relationship, Drug; Epilepsies, Partial; Epilepsy; Humans; V

1983
Controlled and comparative trials of valproate performed in Europe and Asia.
    Epilepsia, 1984, Volume: 25 Suppl 1

    Topics: Adolescent; Adult; Asia; Carbamazepine; Child; Clinical Trials as Topic; Epilepsy; Europe; Humans; P

1984
Controlled and comparative trials with valproate: United States.
    Epilepsia, 1984, Volume: 25 Suppl 1

    Topics: Adolescent; Adult; Child; Child, Preschool; Clinical Trials as Topic; Epilepsy; Epilepsy, Absence; E

1984
l-Tryptophan in hyperactive child syndrome associated with epilepsy: a controlled study.
    Neuropsychobiology, 1983, Volume: 10, Issue:2-3

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Carbamazepine; Child; Clinical Trials as

1983
A randomised trial of strategies to improve patient compliance with anticonvulsant therapy.
    Epilepsia, 1984, Volume: 25, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Counseling; Drug Packag

1984
Role of combination of valproic acid with diphenylhydantoin and carbamazepine in the management of intractable seizures.
    The Journal of the Association of Physicians of India, 1984, Volume: 32, Issue:7

    Topics: Adolescent; Adult; Carbamazepine; Clinical Trials as Topic; Drug Therapy, Combination; Epilepsy; Fem

1984
Clinical efficacy and long-term effects of valproic acid therapy on spike-and-wave discharges.
    Neurology, 1980, Volume: 30, Issue:1

    Topics: Clinical Trials as Topic; Electroencephalography; Epilepsies, Myoclonic; Epilepsy; Epilepsy, Absence

1980
Pharmacokinetics of sodium valproate in epileptic patients: prediction of maintenance dosage by single-dose study.
    European journal of clinical pharmacology, 1980, Volume: 17, Issue:1

    Topics: Adolescent; Adult; Aged; Biological Availability; Child; Drug Administration Schedule; Epilepsy; Fem

1980
The antiepileptic properties of N-dipropylacetamide (depamide): a clinical trial.
    Acta neurologica, 1980, Volume: 2, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Child; Clinical Trials as Topic; Epilepsy; Female; Humans; Male;

1980
Individualized patient assessment in the treatment of epilepsy with sodium valproate.
    Epilepsia, 1980, Volume: 21, Issue:4

    Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; Clinical Trials as Topic; Epilepsy

1980
Comparison of sodium valproate and phenytoin as single drug treatment in epilepsy.
    Epilepsia, 1981, Volume: 22, Issue:1

    Topics: Adolescent; Adult; Aged; Child; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Pregnancy; T

1981
[Leptilan. Dissolution, bioavailability and first therapeutic results in children with different epilepsy forms].
    Fortschritte der Medizin, 1981, Oct-01, Volume: 99, Issue:37

    Topics: Adolescent; Biological Availability; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Valpro

1981
[The treatment of epilepsies with Convulsofin].
    Psychiatrie, Neurologie, und medizinische Psychologie, 1981, Volume: 33, Issue:10

    Topics: Adolescent; Adult; Alanine Transaminase; Aspartate Aminotransferases; Child; Child, Preschool; Clini

1981
A comparison of phenytoin and valproate in previously untreated adult epileptic patients.
    Journal of neurology, neurosurgery, and psychiatry, 1982, Volume: 45, Issue:1

    Topics: Adolescent; Adult; Age Factors; Aged; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Humans

1982
Behavioral changes produced by valproic acid.
    Clinical EEG (electroencephalography), 1982, Volume: 13, Issue:1

    Topics: Adult; Behavior; Clinical Trials as Topic; Drug Interactions; Epilepsy; Humans; Male; Valproic Acid

1982
Controlled trials in epilepsy: a review.
    Epilepsia, 1982, Volume: 23, Issue:5

    Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Carbamazepine; Clinical Trials as Topic; Double-Blin

1982
Treatment of childhood epilepsy with valproic acid: results of the first 100 patients in a 6-month trial.
    Neurology, 1980, Volume: 30, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Clinical Trials as Topic; Epilepsy; Fem

1980
Safety of intravenous valproate.
    Annals of neurology, 1995, Volume: 38, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Epilepsy; Hospitalization; Huma

1995
[Clinical usefulness of pediatric population parameter of slow-releasing preparation of sodium valproate].
    No to hattatsu = Brain and development, 1995, Volume: 27, Issue:4

    Topics: Adolescent; Child; Delayed-Action Preparations; Epilepsy; Female; Humans; Male; Valproic Acid

1995
Effect of valproate and carbamazepine on visual evoked potentials in epileptic children.
    Acta paediatrica Japonica : Overseas edition, 1995, Volume: 37, Issue:3

    Topics: Carbamazepine; Child; Child, Preschool; Epilepsy; Evoked Potentials, Visual; Female; Humans; Male; N

1995
A multiparametric investigation of daytime sleepiness and psychomotor functions in epileptic patients treated with phenobarbital and sodium valproate: a comparative controlled study.
    Electroencephalography and clinical neurophysiology, 1993, Volume: 86, Issue:5

    Topics: Adult; Affect; Analysis of Variance; Epilepsy; Humans; Male; Neuropsychological Tests; Phenobarbital

1993
[The enkorat treatment of infantile spasms and the Lennox-Gastaut syndrome].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 1994, Volume: 94, Issue:6

    Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Clonazepam; Drug Therapy, Combination; Epilepsy; E

1994
Evaluation of binding equation method for prediction of unbound serum valproic acid concentration in pediatric patients with epilepsy.
    International journal of clinical pharmacology and therapeutics, 1995, Volume: 33, Issue:2

    Topics: Adolescent; Blood Proteins; Child; Child, Preschool; Epilepsy; Female; Fluorescence Polarization Imm

1995
Effects of long-term treatment with antiepileptic drugs on serum lipid levels in children with epilepsy.
    Neurology, 1995, Volume: 45, Issue:6

    Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cholesterol; Cholesterol, HDL; Cholesterol,

1995
Renal tubular dysfunction following treatment with anti-epileptic drugs.
    European journal of pediatrics, 1994, Volume: 153, Issue:11

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cross-Sectional Studies; Epilep

1994
Inhibition of phenobarbitone N-glucosidation by valproate.
    British journal of clinical pharmacology, 1994, Volume: 38, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Dose-Response Relationship, Dr

1994
Thrombocytopenia secondary to high valproate levels in children with epilepsy.
    Journal of child neurology, 1994, Volume: 9, Issue:3

    Topics: Carbamazepine; Child; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Male; Platelet Cou

1994
The effect of felbamate on valproic acid disposition.
    Clinical pharmacology and therapeutics, 1994, Volume: 56, Issue:5

    Topics: Adult; Cross-Over Studies; Drug Therapy, Combination; Epilepsy; Felbamate; Female; Humans; Male; Phe

1994
Sensitive capillary gas chromatographic-mass spectrometric method for the therapeutic drug monitoring of valproic acid and seven of its metabolites in human serum. Application of the assay for a group of pediatric epileptics.
    Journal of chromatography. B, Biomedical applications, 1994, Jun-17, Volume: 656, Issue:2

    Topics: Biotransformation; Child; Drug Monitoring; Epilepsy; Gas Chromatography-Mass Spectrometry; Humans; H

1994
Long-term administration of valproic acid in the treatment of affective symptoms in people with mental retardation.
    Journal of clinical psychopharmacology, 1993, Volume: 13, Issue:6

    Topics: Adolescent; Adult; Child; Epilepsy; Female; Humans; Intellectual Disability; Male; Mood Disorders; P

1993
A double-blind, placebo-controlled interaction study between oxcarbazepine and carbamazepine, sodium valproate and phenytoin in epileptic patients.
    British journal of clinical pharmacology, 1994, Volume: 37, Issue:1

    Topics: Adult; Anticonvulsants; Carbamazepine; Double-Blind Method; Drug Interactions; Epilepsy; Female; Hal

1994
Does carnitine administration improve the symptoms attributed to anticonvulsant medications?: a double-blinded, crossover study.
    Pediatrics, 1994, Volume: 93, Issue:6 Pt 1

    Topics: Carbamazepine; Carnitine; Child; Double-Blind Method; Epilepsy; Female; Health Status; Humans; Male;

1994
Pharmacokinetic comparison of two valproic acid formulations--a plain and a controlled release enteric-coated tablets.
    Journal of Korean medical science, 1993, Volume: 8, Issue:4

    Topics: Administration, Oral; Adult; Biological Availability; Delayed-Action Preparations; Epilepsy; Humans;

1993
Developmental and therapeutic pharmacology of antiepileptic drugs.
    The Japanese journal of psychiatry and neurology, 1993, Volume: 47, Issue:2

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Dru

1993
Withdrawal of antiepileptic medication in children--effects on cognitive function: The Multicenter Holmfrid Study.
    Neurology, 1993, Volume: 43, Issue:1

    Topics: Adolescent; Carbamazepine; Child; Cognition; Cognition Disorders; Epilepsy; Female; Follow-Up Studie

1993
Pharmacokinetic interaction between valproic acid and phenobarbital.
    Biopharmaceutics & drug disposition, 1993, Volume: 14, Issue:1

    Topics: Administration, Oral; Adult; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans;

1993
Psychiatric aspects of epilepsy in childhood treated with carbamazepine, phenytoin or sodium valproate: a random trial.
    Developmental medicine and child neurology, 1993, Volume: 35, Issue:2

    Topics: Adolescent; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Follow-Up Studies; Humans; Mal

1993
Lamotrigine for the treatment of epilepsy in childhood.
    The Journal of pediatrics, 1995, Volume: 127, Issue:6

    Topics: Adolescent; Anticonvulsants; Body Weight; Child; Child, Preschool; Consumer Product Safety; Dose-Res

1995
Relationship between valproic acid dosage, plasma concentration and clearance in adult monotherapy patients with epilepsy.
    Journal of clinical pharmacy and therapeutics, 1995, Volume: 20, Issue:4

    Topics: Administration, Oral; Adult; Anticonvulsants; Dose-Response Relationship, Drug; Drug Evaluation; Epi

1995
A comparison of the OPUS and TDx analysers for antiepileptic drug monitoring.
    Therapeutic drug monitoring, 1995, Volume: 17, Issue:5

    Topics: Anticonvulsants; Carbamazepine; Drug Monitoring; Epilepsy; Female; Fluorescence Polarization Immunoa

1995
Activities of antioxidant enzymes and formation of the glutathione adduct of hemoglobin (Hb ASSG) in epileptic patients with long-term antiepileptic therapy.
    Farmaco (Societa chimica italiana : 1989), 1995, Volume: 50, Issue:11

    Topics: Anticonvulsants; Antioxidants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Erythrocytes; Fem

1995
Randomised comparative monotherapy trial of phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed childhood epilepsy.
    Lancet (London, England), 1996, Mar-16, Volume: 347, Issue:9003

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy;

1996
Comparison of antiepileptic drugs on cognitive function in newly diagnosed epileptic children: a psychometric and neurophysiological study.
    Epilepsia, 1996, Volume: 37, Issue:1

    Topics: Adolescent; Anticonvulsants; Bender-Gestalt Test; Carbamazepine; Child; Cognition; Epilepsy; Event-R

1996
Assessment of drowsiness in epilepsy patients receiving chronic antiepileptic drug therapy.
    Epilepsia, 1996, Volume: 37, Issue:2

    Topics: Adult; Age Factors; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsy; Humans; Middle

1996
The effect of carnitine supplementation in valproate-induced hyperammonaemia.
    Acta paediatrica (Oslo, Norway : 1992), 1996, Volume: 85, Issue:4

    Topics: Adolescent; Adult; Ammonia; Anticonvulsants; Carnitine; Chemical and Drug Induced Liver Injury; Chil

1996
Valproic acid treatment of learning disorder and severely epileptiform EEG without clinical seizures.
    Journal of child neurology, 1996, Volume: 11, Issue:1

    Topics: Anticonvulsants; Child; Electroencephalography; Epilepsy; Frontal Lobe; Humans; Learning Disabilitie

1996
Pharmacokinetic interactions between lamotrigine and other antiepileptic drugs in children with intractable epilepsy.
    Epilepsia, 1996, Volume: 37, Issue:8

    Topics: Administration, Oral; Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cl

1996
Antiepileptic drug treatment in pregnancy: drug side effects in the neonate and neurological outcome.
    Acta paediatrica (Oslo, Norway : 1992), 1996, Volume: 85, Issue:6

    Topics: Anticonvulsants; Child; Drug Monitoring; Epilepsy; Female; Follow-Up Studies; Humans; Nervous System

1996
Monitoring free extracellular valproic acid by microdialysis in epileptic patients.
    Therapeutic drug monitoring, 1996, Volume: 18, Issue:1

    Topics: Adult; Anticonvulsants; Chromatography, Gas; Epilepsy; Extracellular Space; Female; Humans; Male; Mi

1996
Effect of valproate on cognitive functioning. Comparison with carbamazepine. The Department of Veterans Affairs Epilepsy Cooperative Study 264 Group.
    Archives of neurology, 1996, Volume: 53, Issue:10

    Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Cognition; Double-Blind Method; Epilepsy; Female; Follo

1996
Serum concentrations of lamotrigine in epileptic patients: the influence of dose and comedication.
    Therapeutic drug monitoring, 1996, Volume: 18, Issue:5

    Topics: Adult; Age Factors; Anticonvulsants; Body Weight; Carbamazepine; Dose-Response Relationship, Drug; D

1996
[Depakine syrup in the treatment of therapy-resistant epilepsy].
    Terapevticheskii arkhiv, 1996, Volume: 68, Issue:10

    Topics: Adolescent; Adult; Anticonvulsants; Chronic Disease; Drug Resistance; Electroencephalography; Epilep

1996
Comparison of the steady-state pharmacokinetics of topiramate and valproate in patients with epilepsy during monotherapy and concomitant therapy.
    Epilepsia, 1997, Volume: 38, Issue:3

    Topics: Adult; Anticonvulsants; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination;

1997
Lamotrigine substitution study: evidence for synergism with sodium valproate? 105 Study Group.
    Epilepsy research, 1997, Volume: 26, Issue:3

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Dose-Response Relationship, Drug; Drug Synergism; Epilepsy

1997
Weight gain with valproate or carbamazepine--a reappraisal.
    Seizure, 1997, Volume: 6, Issue:2

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cross-Over Studies; Dose-Respon

1997
The effectiveness of clonazepam on the Rolandic discharges.
    Brain & development, 1997, Volume: 19, Issue:4

    Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Electroencephalography; Epileps

1997
Lack of pharmacokinetic interaction between remacemide hydrochloride and sodium valproate in epileptic patients.
    Seizure, 1997, Volume: 6, Issue:3

    Topics: Acetamides; Adult; Anticonvulsants; Cross-Over Studies; Double-Blind Method; Drug Interactions; Epil

1997
The mechanism of the carbamazepine-valproate interaction in humans.
    British journal of clinical pharmacology, 1997, Volume: 44, Issue:1

    Topics: Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Mi

1997
Weight gain in epileptic patients during treatment with valproic acid: a retrospective study.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1997, Volume: 24, Issue:3

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Male; Middle Aged

1997
Lamotrigine as add-on drug in children and adolescents with refractory epilepsy and mental delay: an open trial.
    Brain & development, 1997, Volume: 19, Issue:6

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Developmental Disabilities; Drug Resist

1997
Alterations in the carnitine metabolism in epileptic children treated with valproic acid.
    Journal of Korean medical science, 1997, Volume: 12, Issue:6

    Topics: Administration, Oral; Anticonvulsants; Carnitine; Child; Drug Therapy, Combination; Epilepsy; Female

1997
Influence of caffeine on pharmacokinetic profile of sodium valproate and carbamazepine in normal human volunteers.
    Indian journal of experimental biology, 1998, Volume: 36, Issue:1

    Topics: Anticonvulsants; Caffeine; Carbamazepine; Cross-Over Studies; Drug Interactions; Epilepsy; Humans; M

1998
Cognitive effects of anticonvulsant monotherapy in elderly patients: a placebo-controlled study.
    Seizure, 1998, Volume: 7, Issue:2

    Topics: Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Cognition Disorders; Dose-Response Relation

1998
Steady-state serum concentrations of carbamazepine and valproic acid in obese and lean patients with epilepsy.
    Acta medica Okayama, 1998, Volume: 52, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Linear Models; Male; Va

1998
Valproic acid clearance in children with epilepsy.
    Journal of clinical pharmacy and therapeutics, 1998, Volume: 23, Issue:1

    Topics: Age Factors; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Model

1998
[Therapeutic failure, treatment and non-treatment of childhood epilepsy].
    Revista de neurologia, 1998, Volume: 27, Issue:157

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Electroencephalography; Epileps

1998
Serum carnitine levels in epileptic children before and during treatment with valproic acid, carbamazepine, and phenobarbital.
    Journal of child neurology, 1998, Volume: 13, Issue:11

    Topics: Adolescent; Animals; Anticonvulsants; Carbamazepine; Carnitine; Child; Child, Preschool; Epilepsy; H

1998
Effect of antiepileptic drugs on bone mineral density in children between ages 6 and 12 years.
    Clinical pediatrics, 1999, Volume: 38, Issue:2

    Topics: Anticonvulsants; Bone Density; Carbamazepine; Child; Epilepsy; Female; Humans; Lumbar Vertebrae; Mal

1999
Does withdrawal of different antiepileptic drugs have different effects on seizure recurrence? Further results from the MRC Antiepileptic Drug Withdrawal Study.
    Brain : a journal of neurology, 1999, Volume: 122 ( Pt 3)

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Combinations; Epilepsy; Female; Human

1999
Spotlight on the continual applicability of routine plasma monitoring antiepileptic drugs in the treatment of epilepsy.
    Pharmacological research, 1999, Volume: 39, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Monitoring; Drug Therapy, Combination; Epile

1999
The efficacy of felbamate as add-on therapy to valproic acid in the Lennox-Gastaut syndrome.
    Epilepsy research, 1999, Volume: 34, Issue:2-3

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Cross-Over Studies; Double-Blind Method; Drug

1999
Safety and tolerability of gabapentin as adjunctive therapy in a large, multicenter study.
    Epilepsia, 1999, Volume: 40, Issue:7

    Topics: Acetates; Adolescent; Adult; Ambulatory Care; Amines; Anticonvulsants; Asthenia; Carbamazepine; Cycl

1999
Comparative double blind clinical trial of phenytoin and sodium valproate as anticonvulsant prophylaxis after craniotomy: efficacy, tolerability, and cognitive effects.
    Journal of neurology, neurosurgery, and psychiatry, 1999, Volume: 67, Issue:4

    Topics: Adult; Aged; Brain Diseases; Cognition; Craniotomy; Double-Blind Method; Epilepsy; Female; Humans; M

1999
No effect of gender or age on binding characteristics of valproic acid to serum proteins in pediatric patients with epilepsy.
    Journal of clinical pharmacology, 1999, Volume: 39, Issue:10

    Topics: Adolescent; Age Factors; Anticonvulsants; Blood Proteins; Child; Child, Preschool; Epilepsy; Female;

1999
[Depakin 300 and Depakin-chrono in the therapy of epilepsy].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 1999, Volume: 99, Issue:10

    Topics: Adolescent; Adult; Anticonvulsants; Chronic Disease; Electroencephalography; Epilepsy; Female; Human

1999
A multicenter randomized controlled trial on the clinical impact of therapeutic drug monitoring in patients with newly diagnosed epilepsy. The Italian TDM Study Group in Epilepsy.
    Epilepsia, 2000, Volume: 41, Issue:2

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Dizziness; Drug Administration Sched

2000
The effects of carbamazepine and valproic acid on the erythrocyte glutathione, glutathione peroxidase, superoxide dismutase and serum lipid peroxidation in epileptic children.
    Pharmacological research, 2000, Volume: 41, Issue:4

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Erythrocytes; Female;

2000
Plasma and urinary serotonin and 5-HIAA in children treated with lamotrigine for intractable epilepsy.
    Advances in experimental medicine and biology, 1999, Volume: 467

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Epil

1999
Erythrocyte glutathione, glutathione peroxidase, superoxide dismutase and serum lipid peroxidation in epileptic children with valproate and carbamazepine monotherapy.
    Journal of basic and clinical physiology and pharmacology, 2000, Volume: 11, Issue:1

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Erythrocytes; Female;

2000
Adding valproate to lamotrigine: a study of their pharmacokinetic interaction.
    Neurology, 2000, Aug-22, Volume: 55, Issue:4

    Topics: Adolescent; Adult; Aged; Child; Dose-Response Relationship, Drug; Drug Costs; Drug Interactions; Dru

2000
Hyperhomocysteinemia in children treated with sodium valproate and carbamazepine.
    Epilepsy research, 2000, Volume: 41, Issue:3

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Epilepsy; Female; Homocysteine; Humans; Male; Valproic A

2000
Lack of an effect of valproate concentration on lamotrigine pharmacokinetics in developmentally disabled patients with epilepsy.
    Epilepsy research, 2000, Volume: 42, Issue:1

    Topics: Adolescent; Adult; Algorithms; Anticonvulsants; Child; Chromatography, Gas; Chromatography, High Pre

2000
Influence of vitamin D administration on bone ultrasound measurements in patients on anticonvulsant therapy.
    European journal of clinical investigation, 2000, Volume: 30, Issue:10

    Topics: 25-Hydroxyvitamin D 2; Adult; Aged; Anticonvulsants; Bone and Bones; Calcifediol; Carbamazepine; Epi

2000
Open study evaluating lamotrigine efficacy and safety in add-on treatment and consecutive monotherapy in patients with carbamazepine- or valproate-resistant epilepsy.
    Seizure, 2000, Volume: 9, Issue:7

    Topics: Adolescent; Adult; Anticonvulsants; Calcium Channel Blockers; Carbamazepine; Child; Drug Administrat

2000
Epilepsy and antiepileptic drug therapy in juvenile neuronal ceroid lipofuscinosis.
    Epilepsia, 2000, Volume: 41, Issue:10

    Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Child; Child, Preschool; Clonazepam; Comorbidity;

2000
Plasma concentration of valproate following substitution of divalproex sodium by valproic acid.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2000, Volume: 45, Issue:8

    Topics: Anticonvulsants; Drug Evaluation; Epilepsy; Female; Humans; Male; Retrospective Studies; Valproic Ac

2000
Can sodium valproate improve learning in children with epileptiform bursts but without clinical seizures?
    Developmental medicine and child neurology, 2000, Volume: 42, Issue:11

    Topics: Anticonvulsants; Attention; Child; Child Behavior Disorders; Cross-Over Studies; Double-Blind Method

2000
Clinical study of lamotrigine and valproic acid in patients with epilepsy: using a drug interaction to advantage?
    Therapeutic drug monitoring, 2000, Volume: 22, Issue:6

    Topics: Adult; Anticonvulsants; Area Under Curve; Dose-Response Relationship, Drug; Drug Synergism; Drug The

2000
Developmental and therapeutic pharmacology of antiepileptic drugs.
    Epilepsia, 2000, Volume: 41 Suppl 9

    Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Admini

2000
Weight change associated with valproate and lamotrigine monotherapy in patients with epilepsy.
    Neurology, 2001, Jan-23, Volume: 56, Issue:2

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Body Weight; Child; Epilepsy; Female; Humans; Lamotrigine;

2001
Renal tubular dysfunction in epileptic children on valproic acid therapy.
    Pediatric nephrology (Berlin, Germany), 2001, Volume: 16, Issue:3

    Topics: Acetylglucosamine; Adolescent; Anticonvulsants; beta 2-Microglobulin; Child; Cross-Sectional Studies

2001
Influence of carbamazepine-10,11-epoxide on the serum level of valproic acid in epileptic patients on combined treatment with carbamazepine and valproic acid.
    Folia medica, 2000, Volume: 42, Issue:3

    Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Intera

2000
Low serum biotinidase activity in children with valproic acid monotherapy.
    Epilepsia, 2001, Volume: 42, Issue:10

    Topics: Amidohydrolases; Biotinidase; Child; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Liv

2001
Monotherapy versus polytherapy for epilepsy: a multicenter double-blind randomized study.
    Epilepsia, 2001, Volume: 42, Issue:11

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Cognition Disorders; Double-Blind Method; Drug Ad

2001
Randomized double-blind parallel-group study comparing cognitive effects of a low-dose lamotrigine with valproate and placebo in healthy volunteers.
    Epilepsia, 2002, Volume: 43, Issue:1

    Topics: Adult; Affect; Anticonvulsants; Cognition; Double-Blind Method; Epilepsy; Humans; Lamotrigine; Male;

2002
[Evaluation of antiepileptic therapy during pregnancy].
    Ginekologia polska, 2002, Volume: 73, Issue:1

    Topics: Adult; Anticonvulsants; Apgar Score; Drug Therapy, Combination; Epilepsy; Female; Humans; Phenobarbi

2002
Protein binding of valproic acid in Japanese pediatric and adult patients with epilepsy.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2002, May-01, Volume: 59, Issue:9

    Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Blood Proteins; Child; Child, Preschool; Epilepsy;

2002
Topiramate therapeutic monitoring in patients with epilepsy: effect of concomitant antiepileptic drugs.
    Therapeutic drug monitoring, 2002, Volume: 24, Issue:3

    Topics: Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Drug; Dr

2002
Altered pharmacokinetics and metabolism of valproate after replacement of conventional valproate with the slow-release formulation in epileptic patients.
    Pharmacology & toxicology, 2002, Volume: 90, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Child; Delayed-Action Preparations; Epilepsy; Female; Gas Chroma

2002
Proceedings: A controlled trial of sodium valproate in severe epilepsy.
    Electroencephalography and clinical neurophysiology, 1975, Volume: 39, Issue:4

    Topics: Clinical Trials as Topic; Drug Evaluation; Epilepsy; Humans; Valerates; Valproic Acid

1975
Valproic acid (Depakene). A new anticonvulsant agent.
    JAMA, 1978, Nov-10, Volume: 240, Issue:20

    Topics: Animals; Child; Clinical Trials as Topic; Drug Evaluation; Drug Interactions; Epilepsies, Myoclonic;

1978
[Experiences with sodium 2-propyl valerate (Depakine) in the treatment of epilepsy].
    Nederlands tijdschrift voor geneeskunde, 1977, Apr-02, Volume: 121, Issue:14

    Topics: Adolescent; Adult; Aged; Carbamazepine; Cerebrospinal Fluid Shunts; Child; Child, Preschool; Clinica

1977
[Clinical--pharmacological aspects of treatment with sodium di-n-propylacetate].
    Ugeskrift for laeger, 1977, May-02, Volume: 139, Issue:18

    Topics: Clinical Trials as Topic; Drug Evaluation; Epilepsy; Half-Life; In Vitro Techniques; Protein Binding

1977
[Sodium di-n-propylacetate, effect in the treatment of resistant epilepsy. A controlled study].
    Ugeskrift for laeger, 1977, May-02, Volume: 139, Issue:18

    Topics: Adolescent; Adult; Aged; Child; Clinical Trials as Topic; Drug Evaluation; Drug Resistance; Epilepsy

1977
[Sodium di-n-propylacetate: evaluation of its so-called psychotropic effect. A controlled study].
    Ugeskrift for laeger, 1977, May-02, Volume: 139, Issue:18

    Topics: Adolescent; Adult; Child; Clinical Trials as Topic; Drug Evaluation; Epilepsy; Female; Humans; Male;

1977
Valproate sodium: a controlled clinical trial including monitoring of drug levels.
    Epilepsia, 1977, Volume: 18, Issue:2

    Topics: Adult; Child; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Drug Therapy, Combinat

1977
Valproate sodium: evaluation of so-called psychotropic effect. A controlled study.
    Epilepsia, 1977, Volume: 18, Issue:2

    Topics: Adolescent; Adult; Clinical Trials as Topic; Clonazepam; Epilepsy; Female; Humans; Male; Mental Proc

1977
[Problems in serum-level determination during valproic acid therapy].
    Arzneimittel-Forschung, 1977, Volume: 27, Issue:6

    Topics: Adolescent; Adult; Child; Clinical Trials as Topic; Drug Evaluation; Epilepsy; Female; Humans; Male;

1977
[Modification of personality changes in epileptics using dipropylacetate (Convulex). Preliminary communication].
    Wiener medizinische Wochenschrift (1946), 1977, Jun-20, Volume: 127, Issue:12

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Clinical Trials as Topic; Drug Evaluation; Epi

1977
[Double-blind study on the anti-convulsive effect of phenobarbital and valproate in the Lennox syndrome].
    Schweizerische medizinische Wochenschrift, 1978, May-13, Volume: 108, Issue:19

    Topics: Benzodiazepines; Child; Child, Preschool; Double-Blind Method; Drug Synergism; Drug Therapy, Combina

1978
Valproic acid in epilepsy: clinical and pharmacological effects.
    Annals of neurology, 1978, Volume: 3, Issue:1

    Topics: Adult; Binding, Competitive; Biological Availability; Blood Proteins; Clinical Trials as Topic; Drug

1978
Disposition of sodium valproate in epileptic patients.
    British journal of clinical pharmacology, 1978, Volume: 5, Issue:6

    Topics: Adult; Anticonvulsants; Epilepsy; Half-Life; Humans; Kinetics; Male; Valerates; Valproic Acid

1978
Sodium valproate, serum level and clinical effect in epilepsy: a controlled study.
    Epilepsia, 1979, Volume: 20, Issue:3

    Topics: Adolescent; Adult; Aged; Carbamazepine; Clinical Trials as Topic; Dimethadione; Dose-Response Relati

1979
[Natrium valproate, antiepileptic effect--serum concentration. A controlled study].
    Ugeskrift for laeger, 1979, Jul-02, Volume: 141, Issue:27

    Topics: Adolescent; Adult; Aged; Drug Evaluation; Epilepsy; Female; Humans; Male; Middle Aged; Valproic Acid

1979
Sodium valproate: a review of its pharmacological properties and therapeutic efficacy in epilepsy.
    Drugs, 1977, Volume: 13, Issue:2

    Topics: Administration, Oral; Adult; Animals; Anticonvulsants; Behavior; Blood Platelets; Child; Clinical Tr

1977
A double blind study of the influence of dipropylacetate on behaviour.
    Acta neurologica Scandinavica. Supplementum, 1975, Volume: 60

    Topics: Adolescent; Adult; Behavior; Child; Clinical Trials as Topic; Drug Evaluation; Epilepsy; Female; Hum

1975
Controlled trial of sodium valproate in severe epilepsy.
    British medical journal, 1975, Nov-01, Volume: 4, Issue:5991

    Topics: Adult; Clinical Trials as Topic; Drug Evaluation; Drug Interactions; Epilepsy; Female; Humans; Male;

1975
First seizure in adults: to treat or not to treat.
    Clinical neurology and neurosurgery, 1992, Volume: 94 Suppl

    Topics: Adolescent; Adult; Aged; Double-Blind Method; Drug Administration Schedule; Electroencephalography;

1992
A comparative clinical and pharmacokinetic study of a new slow-release versus conventional preparations of valproic acid in children with intractable epilepsy.
    Brain & development, 1992, Volume: 14, Issue:5

    Topics: Adolescent; Child; Child, Preschool; Delayed-Action Preparations; Electroencephalography; Epilepsy;

1992
Coadministration of vigabatrin and valproate in children with refractory epilepsy.
    Clinical neuropharmacology, 1992, Volume: 15, Issue:6

    Topics: 4-Aminobutyrate Transaminase; Adolescent; Aminocaproates; Anticonvulsants; Blood Platelets; Child; D

1992
Conventional and controlled release valproate in children with epilepsy: a cross-over study comparing plasma levels and cognitive performances.
    Epilepsy research, 1992, Volume: 13, Issue:3

    Topics: Adolescent; Attention; Child; Child, Preschool; Cognition; Delayed-Action Preparations; Epilepsy; Fe

1992
Comparison of sprinkle versus syrup formulations of valproate for bioavailability, tolerance, and preference.
    The Journal of pediatrics, 1992, Volume: 120, Issue:4 Pt 1

    Topics: Absorption; Adolescent; Biological Availability; Chemistry, Pharmaceutical; Child; Child, Preschool;

1992
Differential effects of valproic acid and enzyme-inducing anticonvulsants on nimodipine pharmacokinetics in epileptic patients.
    British journal of clinical pharmacology, 1991, Volume: 32, Issue:3

    Topics: Adult; Anticonvulsants; Drug Interactions; Enzyme Induction; Epilepsy; Female; Half-Life; Humans; Ma

1991
Cognitive impairment in new cases of epilepsy randomly assigned to carbamazepine, phenytoin and sodium valproate.
    Developmental medicine and child neurology, 1991, Volume: 33, Issue:6

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cognition; Epilepsy; Humans; In

1991
Valproate sodium in epilepsy. A clinical trial including monitoring of drug levels.
    The Journal of the Association of Physicians of India, 1990, Volume: 38, Issue:4

    Topics: Adolescent; Adult; Child; Clinical Trials as Topic; Electroencephalography; Epilepsy; Female; Humans

1990
A controlled study with taltrimide and sodium valproate: valproate effective in partial epilepsy.
    Acta neurologica Scandinavica, 1990, Volume: 82, Issue:2

    Topics: Adolescent; Adult; Ambulatory Care; Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; F

1990
Discontinuation of antiepileptic drugs in children who have outgrown epilepsy: effects on cognitive function.
    Epilepsia, 1990, Volume: 31 Suppl 4

    Topics: Adolescent; Anticonvulsants; Attention; Carbamazepine; Child; Cognition; Epilepsy; Ethosuximide; Hum

1990
[Clinical and experimental control of optimal therapy in epilepsy].
    Psychiatrie, Neurologie, und medizinische Psychologie, 1990, Volume: 42, Issue:9

    Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Humans; Neurocognitive Disorder

1990
Effectiveness and plasma levels of sodium valproate monotherapy in the treatment of epilepsies in children: a further study.
    The Japanese journal of psychiatry and neurology, 1989, Volume: 43, Issue:3

    Topics: Child; Dose-Response Relationship, Drug; Drug Administration Schedule; Electroencephalography; Epile

1989
Serum levels of sodium valproate, phenytoin and carbamazepine and seizure control in epilepsy.
    Irish medical journal, 1986, Volume: 79, Issue:6

    Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; Fema

1986
A comparative study of progabide, valproate, and placebo as add-on therapy in patients with refractory epilepsy.
    Journal of neurology, neurosurgery, and psychiatry, 1986, Volume: 49, Issue:11

    Topics: Adolescent; Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Interactions; Drug

1986
Valproate monotherapy in the management of generalized and partial seizures.
    Epilepsia, 1987, Volume: 28 Suppl 2

    Topics: Clinical Trials as Topic; Epilepsies, Partial; Epilepsy; Follow-Up Studies; Humans; Remission Induct

1987
Monotherapy with valproate in primary generalized epilepsies.
    Epilepsia, 1987, Volume: 28 Suppl 2

    Topics: Adolescent; Adult; Child; Child, Preschool; Clinical Trials as Topic; Dose-Response Relationship, Dr

1987
Withdrawal of anticonvulsant drugs in patients free of seizures for two years. A prospective study.
    The New England journal of medicine, 1988, Apr-14, Volume: 318, Issue:15

    Topics: Adult; Analysis of Variance; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsies, Par

1988
Effects of sodium valproate on haem biosynthesis in man: implications for seizure management in the porphyric patient.
    European journal of clinical investigation, 1988, Volume: 18, Issue:1

    Topics: 5-Aminolevulinate Synthetase; Adolescent; Adult; Drug Administration Schedule; Epilepsy; Female; Hem

1988
Withdrawal symptoms from phenytoin, carbamazepine and sodium valproate.
    Journal of neurology, neurosurgery, and psychiatry, 1988, Volume: 51, Issue:7

    Topics: Adolescent; Adult; Aged; Carbamazepine; Clinical Trials as Topic; Double-Blind Method; Drug Therapy,

1988
Which drug for the adult epileptic patient: phenytoin or valproate?
    British medical journal (Clinical research ed.), 1985, Mar-16, Volume: 290, Issue:6471

    Topics: Adolescent; Adult; Aged; Body Weight; Clinical Trials as Topic; Epilepsies, Partial; Epilepsy; Femal

1985
[Efficient serum concentrations after single doses of antiepileptic drugs: concept of loading-dose].
    Arquivos de neuro-psiquiatria, 1985, Volume: 43, Issue:1

    Topics: Absorption; Administration, Oral; Carbamazepine; Clinical Trials as Topic; Double-Blind Method; Epil

1985
[Trial of a new antiepileptic drug, magnesium dipropyl acetate].
    Acta neurologica latinoamericana, 1973, Volume: 19, Issue:1-4

    Topics: Adolescent; Adult; Child; Child, Preschool; Clinical Trials as Topic; Drug Evaluation; Epilepsy; Hum

1973

Other Studies

2089 other studies available for valproic acid and Aura

ArticleYear
Functionalized DL-amino acid derivatives. Potent new agents for the treatment of epilepsy.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:3

    Topics: Amino Acids; Animals; Anticonvulsants; Epilepsy; Magnetic Resonance Spectroscopy; Male; Mice; Seizur

1987
Synthesis and evaluation of N-(phenylacetyl)trifluoromethanesulfonamides as anticonvulsant agents.
    Journal of medicinal chemistry, 1996, Mar-29, Volume: 39, Issue:7

    Topics: Animals; Anticonvulsants; Body Weight; Cytochrome P-450 Enzyme System; Epilepsy; Mesylates; Mice; NA

1996
Alpha-fluoro-2,2,3,3-tetramethylcyclopropanecarboxamide, a novel potent anticonvulsant derivative of a cyclic analogue of valproic acid.
    Journal of medicinal chemistry, 2009, Apr-23, Volume: 52, Issue:8

    Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Cyclopropanes; Epilepsy; Male; Mice; Rats; Ra

2009
Combating oxidative stress in epilepsy: design, synthesis, quantum chemical studies and anticonvulsant evaluation of 1-(substituted benzylidene/ethylidene)-4-(naphthalen-1-yl)semicarbazides.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:7

    Topics: Animals; Anticonvulsants; Antioxidants; Benzylidene Compounds; Drug Design; Electrons; Epilepsy; Mal

2010
Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112).
    Journal of medicinal chemistry, 2013, Nov-27, Volume: 56, Issue:22

    Topics: Absorption; Amides; Animals; Anticonvulsants; Dioxanes; Dogs; Drug Evaluation, Preclinical; Drug Res

2013
Design, synthesis and pharmacological evaluation of N-[4-(4-(alkyl/aryl/heteroaryl)-piperazin-1-yl)-phenyl]-carbamic acid ethyl ester derivatives as novel anticonvulsant agents.
    Bioorganic & medicinal chemistry letters, 2015, Mar-01, Volume: 25, Issue:5

    Topics: Animals; Anticonvulsants; Carbamates; Drug Design; Electroshock; Epilepsy; Mice; Pentylenetetrazole;

2015
Non-hyperammonaemia valproate-induced encephalopathy: A case report.
    Journal of clinical pharmacy and therapeutics, 2022, Volume: 47, Issue:3

    Topics: Anticonvulsants; Brain Diseases; Epilepsy; Female; Humans; Hyperammonemia; Middle Aged; Valproic Aci

2022
Association of Therapeutic Dose of Valproic Acid and Plasma Glycine Levels in Epileptic Patients.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2021, Volume: 31, Issue:9

    Topics: Anticonvulsants; Cross-Sectional Studies; Epilepsy; Glycine; Humans; Valproic Acid

2021
Treatment with the combination of clavulanic acid and valproic acid led to recovery of neuronal and behavioral deficits in an epilepsy rat model.
    Fundamental & clinical pharmacology, 2021, Volume: 35, Issue:6

    Topics: Animals; Clavulanic Acid; Epilepsy; Kindling, Neurologic; Male; Pentylenetetrazole; Rats; Rats, Wist

2021
[Women with epilepsy before and during pregnancy: a case series of outpatient counseling in a tertiary epilepsy center].
    Der Nervenarzt, 2022, Volume: 93, Issue:6

    Topics: Anticonvulsants; Counseling; Epilepsy; Female; Folic Acid; Humans; Lamotrigine; Levetiracetam; Outpa

2022
UK general practice: Continuing to fail in the care of people with epilepsy?
    Epilepsy & behavior : E&B, 2021, Volume: 124

    Topics: Epilepsy; Female; General Practice; Humans; Primary Health Care; United Kingdom; Valproic Acid

2021
CYP2C19 & UGT1A6 genetic polymorphisms and the impact on Valproic acid-induced weight gain in people with epilepsy: Prospective genetic association study.
    Epilepsy research, 2021, Volume: 177

    Topics: Anticonvulsants; Cytochrome P-450 CYP2C19; Epilepsy; Genetic Association Studies; Genotype; Glucuron

2021
Evaluation of optical coherence tomography findings in adolescents with genetic generalized epilepsy.
    European journal of ophthalmology, 2022, Volume: 32, Issue:6

    Topics: Adolescent; Epilepsy; Epilepsy, Generalized; Humans; Retina; Tomography, Optical Coherence; Valproic

2022
Valproic acid for children below 2 years of age with epilepsy.
    Neurosciences (Riyadh, Saudi Arabia), 2021, Volume: 26, Issue:4

    Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Retrospective Stud

2021
Successful Treatment of Symptomatic Epilepsy with Oral Valproic Acid and Levetiracetam in a Patient with Short-bowel Syndrome.
    Internal medicine (Tokyo, Japan), 2022, May-01, Volume: 61, Issue:9

    Topics: Aged; Anticonvulsants; Epilepsy; Humans; Levetiracetam; Male; Piracetam; Valproic Acid

2022
GABRB3-related epilepsy: novel variants, clinical features and therapeutic implications.
    Journal of neurology, 2022, Volume: 269, Issue:5

    Topics: Electroencephalography; Epilepsies, Myoclonic; Epilepsy; Fever; Humans; Infant; Levetiracetam; Recep

2022
Effect of valproate and add-on levetiracetam on inflammatory biomarkers in children with epilepsy.
    Epilepsy & behavior : E&B, 2021, Volume: 125

    Topics: Anticonvulsants; Biomarkers; Child; Epilepsy; Humans; Levetiracetam; Neuroinflammatory Diseases; Pir

2021
Pre-pregnancy counseling for women with epilepsy: Can we do better?
    Epilepsy & behavior : E&B, 2021, Volume: 125

    Topics: Anticonvulsants; Counseling; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complications; Teratogen

2021
Factors Influencing Sodium Valproate Serum Concentrations in Patients with Epilepsy Based on Logistic Regression Analysis.
    Medical science monitor : international medical journal of experimental and clinical research, 2021, Nov-15, Volume: 27

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Child; Child, Preschool; D

2021
Long-term use of valproic acid reduced mortality in bipolar disorder patients in a Taiwanese population: An association analysis using the national health insurance research database (NHIRD).
    Journal of psychiatric research, 2022, Volume: 149

    Topics: Bipolar Disorder; Epilepsy; Humans; Lithium; Male; National Health Programs; Valproic Acid

2022
Correlation of GSTP1 rs1695 and CAT rs769217 with elevated AST induced by valproate sodium in Chinese children with epilepsy.
    Pakistan journal of pharmaceutical sciences, 2021, Volume: 34, Issue:5

    Topics: Adolescent; Anticonvulsants; Aspartate Aminotransferases; Catalase; Chemical and Drug Induced Liver

2021
Interaction between valproic acid and meropenem or ertapenem in patients with epilepsy: clinical relevance and results from pharmaceutical intervention.
    Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria, 2021, 09-28, Volume: 45, Issue:6

    Topics: Aged; Anti-Bacterial Agents; Anticonvulsants; Drug Interactions; Epilepsy; Ertapenem; Humans; Male;

2021
Serum folate levels in children on long-term anti-seizure medication in a Nigerian tertiary center-Implications for practice and public health.
    Science progress, 2021, Volume: 104, Issue:4

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Folic Acid; Humans; I

2021
Impact of recommendations on sodium valproate prescription among women with epilepsy: An interrupted time-series study.
    Epilepsy & behavior : E&B, 2021, Volume: 125

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Infan

2021
Predicting the occurrence of thrombocytopenia from free valproate levels: A prospective study.
    Seizure, 2022, Volume: 94

    Topics: Anticonvulsants; Epilepsy; Humans; Prospective Studies; Thrombocytopenia; Valproic Acid

2022
Transgenerational adverse effects of valproate? A patient report from 90 affected families.
    Birth defects research, 2022, 01-01, Volume: 114, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Cleft Lip; Cleft Palate; Drug-Related Side Ef

2022
Analysis of gut microbiota in patients with epilepsy treated with valproate: Results from a three months observational prospective cohort study.
    Microbial pathogenesis, 2022, Volume: 162

    Topics: Epilepsy; Gastrointestinal Microbiome; Humans; Microbiota; Prospective Studies; Valproic Acid

2022
Effect of Valproic Acid on Maternal - Fetal Heart Rates and Coupling in Mice on Embryonic day 15.5 (E15.5).
    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2021, Volume: 2021

    Topics: Animals; Autism Spectrum Disorder; Epilepsy; Female; Fetus; Heart Rate, Fetal; Mice; Pregnancy; Valp

2021
Valproate Restrictions in Sweden and Norway: Online survey suggests implementation deficit.
    Acta neurologica Scandinavica, 2022, Volume: 145, Issue:5

    Topics: Anticonvulsants; Child, Preschool; Epilepsy; Female; Humans; Norway; Pregnancy; Sweden; Valproic Aci

2022
Effects of Low- and High-Dose Valproic Acid and Lamotrigine on the Heart in Female Rats.
    Cardiovascular toxicology, 2022, Volume: 22, Issue:4

    Topics: Animals; Anticonvulsants; Epilepsy; Female; Humans; Lamotrigine; Rats; Triazines; Valproic Acid

2022
Valproate prescription to women of childbearing age in English primary care: repeated cross-sectional analyses and retrospective cohort study.
    BMC pregnancy and childbirth, 2022, Jan-27, Volume: 22, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Cohort Studies; Contraceptio

2022
Achieving neurologically desirable outcomes to pregnancy in women with epilepsy.
    Epilepsy & behavior : E&B, 2022, Volume: 129

    Topics: Anticonvulsants; Australia; Epilepsy; Female; Humans; Levetiracetam; Pregnancy; Pregnancy Complicati

2022
Changes in the use of antiseizure medications in children and adolescents in Norway, 2009-2018.
    Epilepsy research, 2022, Volume: 181

    Topics: Adolescent; Adult; Anticonvulsants; Child; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam; Val

2022
Antiseizure medication treatment pathways for US Medicare beneficiaries with newly treated epilepsy.
    Epilepsia, 2022, Volume: 63, Issue:6

    Topics: Aged; Anticonvulsants; Epilepsy; Gabapentin; Humans; Lacosamide; Lamotrigine; Levetiracetam; Medicar

2022
Trends in antiseizure medication prescription patterns among all adults, women, and older adults with epilepsy: A German longitudinal analysis from 2008 to 2020.
    Epilepsy & behavior : E&B, 2022, Volume: 130

    Topics: Aged; Anticonvulsants; Benzodiazepines; Carbamazepine; Drug Prescriptions; Epilepsy; Epilepsy, Gener

2022
National compliance with UK wide guidelines for usage of valproate in women of childbearing potential.
    Seizure, 2022, Volume: 98

    Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy; Female; Humans; Infant; Pregnancy; United Kingdom; V

2022
Clinical Evaluation of Levetiracetam in the Treatment of Epilepsy.
    Journal of healthcare engineering, 2022, Volume: 2022

    Topics: Anticonvulsants; Epilepsy; Humans; Levetiracetam; Phenytoin; Valproic Acid

2022
Response to lithium and anticonvulsants among patients with bipolar disorder with and without comorbid epilepsy - A nation-wide population-based longitudinal study.
    Journal of affective disorders, 2022, 07-01, Volume: 308

    Topics: Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Comorbidity; Epilepsy; Humans; Lamotrigine;

2022
Trends in the prescription of anti-seizure medicines for pregnant women outpatients with epilepsy during 2016-2020 in Japan.
    Seizure, 2022, Volume: 98

    Topics: Anticonvulsants; Epilepsy; Female; Humans; Japan; Lamotrigine; Levetiracetam; Outpatients; Pregnancy

2022
ARHGEF9 gene variant leads to developmental and epileptic encephalopathy: Genotypic phenotype analysis and treatment exploration.
    Molecular genetics & genomic medicine, 2022, Volume: 10, Issue:7

    Topics: Epilepsy; Epilepsy, Generalized; Humans; Levetiracetam; Phenotype; Retrospective Studies; Rho Guanin

2022
Association of Prenatal Exposure to Antiseizure Medication With Risk of Autism and Intellectual Disability.
    JAMA neurology, 2022, 07-01, Volume: 79, Issue:7

    Topics: Anticonvulsants; Autism Spectrum Disorder; Autistic Disorder; Carbamazepine; Child; Cohort Studies;

2022
Comprehensive strategy required to eliminate valproate prescribing in pregnancy.
    BMJ (Clinical research ed.), 2022, 05-31, Volume: 377

    Topics: Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Valproic Acid

2022
[Clinical features of epilepsy in 5 children with Mowat-Wilson syndrome].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2022, Jun-02, Volume: 60, Issue:6

    Topics: Child; Electroencephalography; Epilepsy; Facies; Female; Hirschsprung Disease; Humans; Intellectual

2022
Assessment of asymmetric dimethylarginine and homocysteine in epileptic children receiving antiepileptic drugs.
    Pediatric research, 2022, Volume: 92, Issue:6

    Topics: Anticonvulsants; Arginine; Carotid Intima-Media Thickness; Child; Epilepsy; Homocysteine; Humans; Le

2022
Seizure medication and planned pregnancy: balancing the risks and outcomes.
    Expert review of neurotherapeutics, 2022, Volume: 22, Issue:7

    Topics: Anticonvulsants; Epilepsy; Family Planning Services; Female; Humans; Pregnancy; Pregnancy Complicati

2022
4-Phenylbutyric Acid Plus Valproic Acid Exhibits the Therapeutic and Neuroprotective Effects in Acute Seizures Induced by Pentylenetetrazole.
    Neurochemical research, 2022, Volume: 47, Issue:10

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Male; Neuroprotective Agents; Pentylenet

2022
Differential impact of antenatal exposure to antiseizure medications on motor and mental development in infants of women with epilepsy.
    Epileptic disorders : international epilepsy journal with videotape, 2022, Jun-01, Volume: 24, Issue:3

    Topics: Anticonvulsants; Child; Epilepsy; Female; Humans; Infant; Phenobarbital; Pregnancy; Prenatal Exposur

2022
Risk factors of elevated blood ammonia level in epilepsy patients treated with lamotrigine.
    Medicine, 2022, Jul-01, Volume: 101, Issue:26

    Topics: Ammonia; Anticonvulsants; Epilepsy; Humans; Hyperammonemia; Lamotrigine; Risk Factors; Seizures; Tri

2022
Population pharmacokinetics of oxcarbazepine 10-monohydroxy derivative in Chinese adult epileptic patients.
    European journal of hospital pharmacy : science and practice, 2023, Volume: 30, Issue:e1

    Topics: Adult; Anticonvulsants; Carbamazepine; East Asian People; Epilepsy; Humans; Oxcarbazepine; Polymorph

2023
Dried Blood Spots as Matrix for Evaluation of Valproate Levels and the Immediate and Delayed Metabolomic Changes Induced by Single Valproate Dose Treatment.
    International journal of molecular sciences, 2022, Jun-25, Volume: 23, Issue:13

    Topics: Animals; Dried Blood Spot Testing; Epilepsy; Female; Gas Chromatography-Mass Spectrometry; Male; Met

2022
Efficacy and safety of antiseizure medication in post-stroke epilepsy.
    Seizure, 2022, Volume: 100

    Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy; Humans; Lacosamide; Lamotrigine; Levetiracetam; Seiz

2022
[Prospects for the development of new prolonged forms of valproic acid derivatives for the relief of convulsive syndrome].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2022, Volume: 122, Issue:7

    Topics: Alcoholism; Anticonvulsants; Epilepsy; Humans; Seizures; Substance Withdrawal Syndrome; Valproic Aci

2022
[Epilepsy in Angelman syndrome].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2022, Volume: 122, Issue:7

    Topics: Angelman Syndrome; Anticonvulsants; Child; Electroencephalography; Epilepsy; Ethosuximide; Female; H

2022
HYPERAMMONAEMIA AND COGNITIVE IMPAIRMENT IN EPILEPSY PATIENTS TREATED WITH VALPROIC ACID - PRELIMINARY STUDY.
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 2022, Volume: 75, Issue:6

    Topics: Ammonia; Anticonvulsants; Cognitive Dysfunction; Dementia; Epilepsy; Female; Humans; Hyperammonemia;

2022
Scaling up monitoring of risk minimization measures in women of childbearing age with anti-seizure medicines.
    Seizure, 2022, Volume: 100

    Topics: Anticonvulsants; Epilepsy; Europe; Female; Humans; Japan; Valproic Acid

2022
Valproate Teratogenicity: A Moving Target.
    Obstetrics and gynecology, 2022, 09-01, Volume: 140, Issue:3

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complic

2022
Changes in the first anti-seizure medication prescribed for children and adolescents with epilepsy in a tertiary clinical center in Serbia over two decades.
    International journal of clinical pharmacology and therapeutics, 2022, Volume: 60, Issue:10

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Cross-Sectional Studies; Epilepsy; Fema

2022
Irritability and its relationship with psychosocial symptoms and quality of life in adolescents with epilepsy receiving levetiracetam therapy: A case-control study.
    Epilepsy & behavior : E&B, 2022, Volume: 135

    Topics: Adolescent; Anticonvulsants; Case-Control Studies; Child; Cross-Sectional Studies; Epilepsy; Humans;

2022
Identification of factors associated with new-onset vascular disease in patients admitted for video-EEG monitoring: A longitudinal cohort study.
    Epilepsy & behavior : E&B, 2022, Volume: 135

    Topics: Adolescent; Adult; Child; Child, Preschool; Cohort Studies; Electroencephalography; Epilepsy; Female

2022
Simultaneous determination of plasma lamotrigine, lamotrigine N2-glucuronide and lamotrigine N2-oxide by UHPLC-MS/MS in epileptic patients.
    Journal of pharmaceutical and biomedical analysis, 2022, Oct-25, Volume: 220

    Topics: Anticonvulsants; Chromatography, High Pressure Liquid; Epilepsy; Glucuronides; Humans; Lamotrigine;

2022
Investigation into Antiepileptic Effect of Ganoderic Acid A and Its Mechanism in Seizure Rats Induced by Pentylenetetrazole.
    BioMed research international, 2022, Volume: 2022

    Topics: Animals; Anticonvulsants; bcl-2-Associated X Protein; Caspase 3; Epilepsy; Heptanoic Acids; Lanoster

2022
Effects of antiepileptic drugs polytherapy on pregnancy outcomes in women with epilepsy: An observation study in northwest China.
    Epilepsy & behavior : E&B, 2022, Volume: 135

    Topics: Anticonvulsants; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam; Male; Phenobarbital; Pregnanc

2022
Association between anti-seizure medication and the risk of lower urinary tract infection in patients with epilepsy.
    Epilepsy & behavior : E&B, 2022, Volume: 135

    Topics: Adult; Anti-Bacterial Agents; Anticonvulsants; Carbamazepine; Epilepsy; Female; Gabapentin; Humans;

2022
Epilepsy and pregnancy. Factors associated with epileptic seizures during pregnancy.
    Neurologia, 2023, Volume: 38, Issue:2

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam; Pregnancy; Seizures; V

2023
Clinical and electroencephalographic features of epilepsy in patients with triple X syndrome: A case series.
    Seizure, 2022, Volume: 102

    Topics: Anticonvulsants; Electroencephalography; Epilepsy; Female; Humans; Levetiracetam; Retrospective Stud

2022
The effect of valproic acid and furosemide on the regulation of the inflammasome complex (NLRP1 and NLRP3 mRNA) in the brain of epileptic animal model.
    Brain research bulletin, 2022, Volume: 191

    Topics: Animals; Brain; Disease Models, Animal; DNA-Binding Proteins; Epilepsy; Furosemide; Inflammasomes; M

2022
How does foetal exposure to valproate produce adverse neurodevelopmental outcomes?
    Brain : a journal of neurology, 2022, 11-21, Volume: 145, Issue:11

    Topics: Anticonvulsants; Epilepsy; Genomics; Humans; Valproic Acid

2022
Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks.
    Epilepsia, 2022, Volume: 63, Issue:10

    Topics: Animals; Calcium; Epilepsy; Reproducibility of Results; Seizures; Valproic Acid; Zebrafish

2022
Trimetazidine, an Anti-Ischemic Drug, Reduces the Antielectroshock Effects of Certain First-Generation Antiepileptic Drugs.
    International journal of molecular sciences, 2022, Sep-26, Volume: 23, Issue:19

    Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease Models, Animal; Dose-Res

2022
Imatinib Attenuates Pentylenetetrazole Kindled and Pilocarpine Induced Recurrent Spontaneous Seizures in Mice.
    Neurochemical research, 2023, Volume: 48, Issue:2

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Imatinib Mesylate; Mice; Pentylenetetraz

2023
A heterozygous missense variant in the YWHAG gene causing developmental and epileptic encephalopathy 56 in a Chinese family.
    BMC medical genomics, 2022, 10-15, Volume: 15, Issue:1

    Topics: 14-3-3 Proteins; China; Epilepsy; Heterozygote; Humans; Mutation, Missense; Seizures; Valproic Acid

2022
Addressing the Problem of Prescription of Valproate to Women of Childbearing Age: Reply to Tastenhoye et al.
    The Journal of clinical psychiatry, 2022, 10-12, Volume: 83, Issue:6

    Topics: Anticonvulsants; Epilepsy; Female; Humans; Prescriptions; Valproic Acid

2022
Impact of MDR1 and UGT Gene Polymorphisms on Sodium Valproate Plasma Concentration in Patients with Epilepsy.
    Clinical laboratory, 2022, Oct-01, Volume: 68, Issue:10

    Topics: Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Delayed-Action Preparation

2022
Anti-seizure mechanisms of midazolam and valproate at the β2(L51M) variant of the GABA
    Neuropharmacology, 2022, Dec-15, Volume: 221

    Topics: Epilepsy; gamma-Aminobutyric Acid; Humans; Midazolam; Receptors, GABA-A; Valproic Acid

2022
Efficacy of antiseizure medication in a mouse model of HCN1 developmental and epileptic encephalopathy.
    Epilepsia, 2023, Volume: 64, Issue:1

    Topics: Animals; Anticonvulsants; Epilepsy; Epilepsy, Generalized; Hyperpolarization-Activated Cyclic Nucleo

2023
Serum folate levels in children with epilepsy seen in a tertiary health care facility in north central Nigeria.
    Nigerian journal of clinical practice, 2022, Volume: 25, Issue:10

    Topics: Anticonvulsants; Carbamazepine; Child; Cross-Sectional Studies; Delivery of Health Care; Epilepsy; F

2022
Insulin Resistance in children on Sodium Valproate - A hospital based cross-sectional study in Indian children.
    Tropical doctor, 2023, Volume: 53, Issue:1

    Topics: Anticonvulsants; Child; Cross-Sectional Studies; Epilepsy; Humans; Insulin Resistance; Valproic Acid

2023
Overexpression of Homer1b/c induces valproic acid resistance in epilepsy.
    CNS neuroscience & therapeutics, 2023, Volume: 29, Issue:1

    Topics: Animals; Anticonvulsants; Epilepsy; Mice; Pentylenetetrazole; Rats; Receptor, Metabotropic Glutamate

2023
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
    Metabolic brain disease, 2023, Volume: 38, Issue:2

    Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA

2023
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
    Metabolic brain disease, 2023, Volume: 38, Issue:2

    Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA

2023
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
    Metabolic brain disease, 2023, Volume: 38, Issue:2

    Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA

2023
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
    Metabolic brain disease, 2023, Volume: 38, Issue:2

    Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA

2023
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
    Metabolic brain disease, 2023, Volume: 38, Issue:2

    Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA

2023
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
    Metabolic brain disease, 2023, Volume: 38, Issue:2

    Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA

2023
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
    Metabolic brain disease, 2023, Volume: 38, Issue:2

    Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA

2023
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
    Metabolic brain disease, 2023, Volume: 38, Issue:2

    Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA

2023
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
    Metabolic brain disease, 2023, Volume: 38, Issue:2

    Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA

2023
Valproic Acid-Induced Upregulation of Multidrug Efflux Transporter ABCG2/BCRP via PPAR
    Molecular pharmacology, 2023, Volume: 103, Issue:3

    Topics: Anticonvulsants; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Trans

2023
Valproic Acid-Induced Upregulation of Multidrug Efflux Transporter ABCG2/BCRP via PPAR
    Molecular pharmacology, 2023, Volume: 103, Issue:3

    Topics: Anticonvulsants; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Trans

2023
Valproic Acid-Induced Upregulation of Multidrug Efflux Transporter ABCG2/BCRP via PPAR
    Molecular pharmacology, 2023, Volume: 103, Issue:3

    Topics: Anticonvulsants; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Trans

2023
Valproic Acid-Induced Upregulation of Multidrug Efflux Transporter ABCG2/BCRP via PPAR
    Molecular pharmacology, 2023, Volume: 103, Issue:3

    Topics: Anticonvulsants; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Trans

2023
Valproic Acid-Induced Upregulation of Multidrug Efflux Transporter ABCG2/BCRP via PPAR
    Molecular pharmacology, 2023, Volume: 103, Issue:3

    Topics: Anticonvulsants; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Trans

2023
Valproic Acid-Induced Upregulation of Multidrug Efflux Transporter ABCG2/BCRP via PPAR
    Molecular pharmacology, 2023, Volume: 103, Issue:3

    Topics: Anticonvulsants; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Trans

2023
Valproic Acid-Induced Upregulation of Multidrug Efflux Transporter ABCG2/BCRP via PPAR
    Molecular pharmacology, 2023, Volume: 103, Issue:3

    Topics: Anticonvulsants; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Trans

2023
Valproic Acid-Induced Upregulation of Multidrug Efflux Transporter ABCG2/BCRP via PPAR
    Molecular pharmacology, 2023, Volume: 103, Issue:3

    Topics: Anticonvulsants; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Trans

2023
Valproic Acid-Induced Upregulation of Multidrug Efflux Transporter ABCG2/BCRP via PPAR
    Molecular pharmacology, 2023, Volume: 103, Issue:3

    Topics: Anticonvulsants; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Trans

2023
Supply problems of antiseizure medication are common among epilepsy patients in Germany.
    Epilepsy & behavior : E&B, 2023, Volume: 138

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Germany; Humans; Medication Adherence; Valproic Acid

2023
Supply problems of antiseizure medication are common among epilepsy patients in Germany.
    Epilepsy & behavior : E&B, 2023, Volume: 138

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Germany; Humans; Medication Adherence; Valproic Acid

2023
Supply problems of antiseizure medication are common among epilepsy patients in Germany.
    Epilepsy & behavior : E&B, 2023, Volume: 138

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Germany; Humans; Medication Adherence; Valproic Acid

2023
Supply problems of antiseizure medication are common among epilepsy patients in Germany.
    Epilepsy & behavior : E&B, 2023, Volume: 138

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Germany; Humans; Medication Adherence; Valproic Acid

2023
Supply problems of antiseizure medication are common among epilepsy patients in Germany.
    Epilepsy & behavior : E&B, 2023, Volume: 138

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Germany; Humans; Medication Adherence; Valproic Acid

2023
Supply problems of antiseizure medication are common among epilepsy patients in Germany.
    Epilepsy & behavior : E&B, 2023, Volume: 138

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Germany; Humans; Medication Adherence; Valproic Acid

2023
Supply problems of antiseizure medication are common among epilepsy patients in Germany.
    Epilepsy & behavior : E&B, 2023, Volume: 138

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Germany; Humans; Medication Adherence; Valproic Acid

2023
Supply problems of antiseizure medication are common among epilepsy patients in Germany.
    Epilepsy & behavior : E&B, 2023, Volume: 138

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Germany; Humans; Medication Adherence; Valproic Acid

2023
Supply problems of antiseizure medication are common among epilepsy patients in Germany.
    Epilepsy & behavior : E&B, 2023, Volume: 138

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Germany; Humans; Medication Adherence; Valproic Acid

2023
Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations.
    Annals of neurology, 2023, Volume: 93, Issue:3

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Benzodiazepines; Carbamazepine; Cohort Studies; Epilep

2023
Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations.
    Annals of neurology, 2023, Volume: 93, Issue:3

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Benzodiazepines; Carbamazepine; Cohort Studies; Epilep

2023
Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations.
    Annals of neurology, 2023, Volume: 93, Issue:3

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Benzodiazepines; Carbamazepine; Cohort Studies; Epilep

2023
Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations.
    Annals of neurology, 2023, Volume: 93, Issue:3

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Benzodiazepines; Carbamazepine; Cohort Studies; Epilep

2023
Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations.
    Annals of neurology, 2023, Volume: 93, Issue:3

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Benzodiazepines; Carbamazepine; Cohort Studies; Epilep

2023
Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations.
    Annals of neurology, 2023, Volume: 93, Issue:3

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Benzodiazepines; Carbamazepine; Cohort Studies; Epilep

2023
Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations.
    Annals of neurology, 2023, Volume: 93, Issue:3

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Benzodiazepines; Carbamazepine; Cohort Studies; Epilep

2023
Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations.
    Annals of neurology, 2023, Volume: 93, Issue:3

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Benzodiazepines; Carbamazepine; Cohort Studies; Epilep

2023
Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations.
    Annals of neurology, 2023, Volume: 93, Issue:3

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Benzodiazepines; Carbamazepine; Cohort Studies; Epilep

2023
Valproic acid-induced hyperammonemia in neuropsychiatric disorders: a 2-year clinical survey.
    Psychopharmacology, 2023, Volume: 240, Issue:1

    Topics: Ammonia; Anticonvulsants; Epilepsy; Humans; Hyperammonemia; Risperidone; Valproic Acid

2023
Valproic acid-induced hyperammonemia in neuropsychiatric disorders: a 2-year clinical survey.
    Psychopharmacology, 2023, Volume: 240, Issue:1

    Topics: Ammonia; Anticonvulsants; Epilepsy; Humans; Hyperammonemia; Risperidone; Valproic Acid

2023
Valproic acid-induced hyperammonemia in neuropsychiatric disorders: a 2-year clinical survey.
    Psychopharmacology, 2023, Volume: 240, Issue:1

    Topics: Ammonia; Anticonvulsants; Epilepsy; Humans; Hyperammonemia; Risperidone; Valproic Acid

2023
Valproic acid-induced hyperammonemia in neuropsychiatric disorders: a 2-year clinical survey.
    Psychopharmacology, 2023, Volume: 240, Issue:1

    Topics: Ammonia; Anticonvulsants; Epilepsy; Humans; Hyperammonemia; Risperidone; Valproic Acid

2023
Effect of valproate on sleep patterns disturbed by epilepsy.
    Physiology & behavior, 2023, 02-01, Volume: 259

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Quality of Life; Rat

2023
Effect of valproate on sleep patterns disturbed by epilepsy.
    Physiology & behavior, 2023, 02-01, Volume: 259

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Quality of Life; Rat

2023
Effect of valproate on sleep patterns disturbed by epilepsy.
    Physiology & behavior, 2023, 02-01, Volume: 259

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Quality of Life; Rat

2023
Effect of valproate on sleep patterns disturbed by epilepsy.
    Physiology & behavior, 2023, 02-01, Volume: 259

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Quality of Life; Rat

2023
Determination of valproic acid and its six metabolites in human serum using LC-MS/MS and application to interaction with carbapenems in epileptic patients.
    Biomedical chromatography : BMC, 2023, Volume: 37, Issue:3

    Topics: Anticonvulsants; Carbapenems; Chromatography, Liquid; Epilepsy; Humans; Tandem Mass Spectrometry; Va

2023
Determination of valproic acid and its six metabolites in human serum using LC-MS/MS and application to interaction with carbapenems in epileptic patients.
    Biomedical chromatography : BMC, 2023, Volume: 37, Issue:3

    Topics: Anticonvulsants; Carbapenems; Chromatography, Liquid; Epilepsy; Humans; Tandem Mass Spectrometry; Va

2023
Determination of valproic acid and its six metabolites in human serum using LC-MS/MS and application to interaction with carbapenems in epileptic patients.
    Biomedical chromatography : BMC, 2023, Volume: 37, Issue:3

    Topics: Anticonvulsants; Carbapenems; Chromatography, Liquid; Epilepsy; Humans; Tandem Mass Spectrometry; Va

2023
Determination of valproic acid and its six metabolites in human serum using LC-MS/MS and application to interaction with carbapenems in epileptic patients.
    Biomedical chromatography : BMC, 2023, Volume: 37, Issue:3

    Topics: Anticonvulsants; Carbapenems; Chromatography, Liquid; Epilepsy; Humans; Tandem Mass Spectrometry; Va

2023
Trends in antiseizure medications utilization among women of childbearing age with epilepsy in Poland between 2015 and 2019.
    Epilepsy & behavior : E&B, 2023, Volume: 139

    Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Epilepsy; Female; Humans; Lamotrigine; Levetiraceta

2023
Novel SYN1 Variant in Two Brothers with Focal Epilepsy and Their Prompt Response to Valproate.
    Neuropediatrics, 2023, Volume: 54, Issue:3

    Topics: Epilepsies, Partial; Epilepsy; Humans; Male; Mammals; Siblings; Synapsins; Valproic Acid

2023
Maintaining equity and reducing risk when prescribing valproate: we still have a way to go.
    Practical neurology, 2023, Volume: 23, Issue:1

    Topics: Anticonvulsants; Epilepsy; Humans; Valproic Acid

2023
Effects of
    Pharmacogenomics, 2023, Volume: 24, Issue:3

    Topics: Anticonvulsants; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; East Asian People; Epilepsy; Gen

2023
Impact of regulatory restrictions on the use of valproic acid in women of childbearing age: An Italian study.
    Epilepsia, 2023, Volume: 64, Issue:4

    Topics: Anticonvulsants; Drug Prescriptions; Epilepsy; Female; Humans; Italy; Valproic Acid

2023
The Effect of Adenosine Signaling on Memory Impairment Induced by Pentylenetetrazole in Zebrafish.
    Neurochemical research, 2023, Volume: 48, Issue:6

    Topics: Adenosine; Animals; Dipyridamole; Epilepsy; Pentylenetetrazole; Quality of Life; Seizures; Valproic

2023
[A severe, reversible encephalopathy after prolonged use of valproic acid].
    Tijdschrift voor psychiatrie, 2023, Volume: 65, Issue:1

    Topics: Aged; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Brain Diseases; Epilepsy; Female; Hum

2023
Long-term outcomes of classic and novel anti-seizure medication in a kainate-induced model of chronic epilepsy.
    Epilepsy research, 2023, Volume: 191

    Topics: Animals; Anticonvulsants; Carbamazepine; Epilepsy; Epilepsy, Temporal Lobe; Kainic Acid; Mice; Valpr

2023
Effects of dosage in new users of lamotrigine inducing epidermal necrolysis: Results of the German Registry of Severe Skin Reactions.
    Epilepsia, 2023, Volume: 64, Issue:5

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Lamotrigine; Male; Registries; Stevens-Johnson Syn

2023
Current treatment options for familial adult myoclonus epilepsy.
    Epilepsia, 2023, Volume: 64 Suppl 1

    Topics: Adult; Anticonvulsants; Epilepsies, Myoclonic; Epilepsy; Humans; Myoclonus; Tremor; Valproic Acid

2023
Efficacy and mechanisms of Dingxian pill combined with valproic acid on pentylenetetrazol-induced chronic epilepsy in rats.
    Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2023, Volume: 43, Issue:2

    Topics: Animals; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Seizures; Valproic Acid

2023
Prescribed antiseizure medication doses and their relation to defined daily doses for achieving seizure freedom in newly diagnosed patients with epilepsy.
    Epilepsia open, 2023, Volume: 8, Issue:3

    Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Epilepsy; Freedom; Humans; Oxcarbazepine; Retrospec

2023
Survey on the management of childhood epilepsy among general practitioners in the area of Marrakech.
    BMC pediatrics, 2023, 04-04, Volume: 23, Issue:1

    Topics: Child; Cross-Sectional Studies; Epilepsy; General Practitioners; Humans; Surveys and Questionnaires;

2023
Analysing patient-generated data to understand behaviours and characteristics of women with epilepsy of childbearing years: A prospective cohort study.
    Seizure, 2023, Volume: 108

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Death, Sudden; Epilepsy; Female; Humans; Middle Aged; Pros

2023
Prenatal Exposure to Antiseizure Medication and Incidence of Childhood- and Adolescence-Onset Psychiatric Disorders.
    JAMA neurology, 2023, 06-01, Volume: 80, Issue:6

    Topics: Adolescent; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Carbamazepine; Child; Ch

2023
A novel method for predicting the unbound valproic acid concentration.
    Drug metabolism and pharmacokinetics, 2023, Volume: 50

    Topics: Anticonvulsants; Epilepsy; Humans; Renal Insufficiency; Retrospective Studies; Valproic Acid

2023
Selection and Continuation of Antiseizure Medication in Children With Epilepsy in Sweden From 2007 to 2020.
    Pediatric neurology, 2023, Volume: 144

    Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Lamotrigine; Levetiracet

2023
Arginase deficiency-An unheralded cause of developmental epileptic encephalopathy.
    Epileptic disorders : international epilepsy journal with videotape, 2023, Volume: 25, Issue:4

    Topics: Child; Epilepsy; Epilepsy, Generalized; Humans; Hyperammonemia; Hyperargininemia; Valproic Acid

2023
Valproate-related hyperammonemic encephalopathy with generalized suppression EEG: a case report.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2023, Volume: 44, Issue:10

    Topics: Adult; Anticonvulsants; Brain Diseases; Electroencephalography; Epilepsy; Female; Humans; Hyperammon

2023
The effect of anti-seizure medications on lipid values in adults with epilepsy.
    Epilepsy & behavior : E&B, 2023, Volume: 144

    Topics: Adult; Epilepsy; Humans; Hypercholesterolemia; Valproic Acid

2023
Acute pancreatitis during valproic acid administration in a patient with vascular dementia, epileptic seizures, and psychiatric symptoms: a case report.
    Journal of medical case reports, 2023, May-29, Volume: 17, Issue:1

    Topics: Acute Disease; Aged; Amylases; Anticonvulsants; Dementia, Vascular; Epilepsy; Humans; Male; Pancreat

2023
Risk of recurrence in patients with an unprovoked tonic-clonic seizure and generalized epileptiform discharges on EEG.
    Epilepsia, 2023, Volume: 64, Issue:8

    Topics: Adult; Electroencephalography; Epilepsy; Humans; Prospective Studies; Recurrence; Seizures; Valproic

2023
Adverse Event Profiles of Antiseizure Medications and the Impact of Coadministration on Drug Tolerability in Adults with Epilepsy.
    CNS drugs, 2023, Volume: 37, Issue:6

    Topics: Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anticonvulsants; Epilepsy; Humans;

2023
Prescribing Trends of Antiseizure Drugs in Women Veterans With Epilepsy.
    Military medicine, 2023, 11-03, Volume: 188, Issue:11-12

    Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Gabapentin; Humans; Lamotrigine; Levetiracetam

2023
Change in Apo B100/A1 Ratio in Children With Epilepsy on Monotherapy With Sodium Valproate, Oxcarbazepine or Levetiracetam.
    Indian pediatrics, 2023, Jun-15, Volume: 60, Issue:6

    Topics: Anticonvulsants; Carbamazepine; Child; Epilepsy; Humans; Levetiracetam; Longitudinal Studies; Oxcarb

2023
Bearing variant alleles at uridine glucuronosyltransferase polymorphisms UGT2B7 -161C > T (rs7668258) or UGT1A4*3 c.142 T > G (rs2011425) has no relevant consequences for lamotrigine troughs in adults with epilepsy.
    European journal of clinical pharmacology, 2023, Volume: 79, Issue:8

    Topics: Adult; Alleles; Anticonvulsants; Bayes Theorem; Epilepsy; Genotype; Glucuronosyltransferase; Humans;

2023
Birth outcomes in pregnant women with epilepsy: A Nationwide multicenter study from Türkiye.
    Epilepsia, 2023, Volume: 64, Issue:9

    Topics: Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant; Infant, Newborn; Lamotrigine; Preg

2023
Utilization of Antiseizure Medications in Women of Childbearing Age With Epilepsy and Nonepilepsy Indications: A Retrospective Cohort Study.
    Neurology, 2023, 09-05, Volume: 101, Issue:10

    Topics: Anticonvulsants; Clonazepam; Diazepam; Epilepsy; Female; Gabapentin; Humans; Lamotrigine; Lorazepam;

2023
SCN1A Polymorphisms and Haplotypes Are Associated With Valproic Acid Treatment Outcomes in Chinese Children With Epilepsy.
    Pediatric neurology, 2023, Volume: 146

    Topics: Anticonvulsants; Child; East Asian People; Epilepsy; Genotype; Haplotypes; Humans; NAV1.1 Voltage-Ga

2023
Prescribing of valproate and oral antiepileptics for women of childbearing age and during pregnancy in Germany between 2010 and 2020.
    Pharmacoepidemiology and drug safety, 2023, Volume: 32, Issue:11

    Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Germany; Humans; Middle Aged; Pregnancy; Presc

2023
Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo.
    Toxicological sciences : an official journal of the Society of Toxicology, 2023, 09-28, Volume: 195, Issue:2

    Topics: Anticonvulsants; Endocrine Disruptors; Epilepsy; Female; Fetus; Humans; Male; Testis; Valproic Acid

2023
Valproate induced carnitine deficiency and hyperammonaemia.
    Clinical medicine (London, England), 2023, Volume: 23, Issue:4

    Topics: Amino Acid Metabolism, Inborn Errors; Anticonvulsants; Carnitine; Epilepsy; Humans; Hyperammonemia;

2023
Valproate associated brain volume-loss in pediatric epilepsy-A case series.
    Epilepsia open, 2023, Volume: 8, Issue:4

    Topics: Aged, 80 and over; Brain; Child; Epilepsy; Gray Matter; Humans; Valproic Acid; White Matter

2023
Epilepsy and long-term risk of arrhythmias.
    European heart journal, 2023, 09-14, Volume: 44, Issue:35

    Topics: Atrial Fibrillation; Carbamazepine; Epilepsy; Genetic Predisposition to Disease; Humans; Valproic Ac

2023
[Safe and Effective Management of Epilepsy in Pregnancy].
    Brain and nerve = Shinkei kenkyu no shinpo, 2023, Volume: 75, Issue:9

    Topics: Anticonvulsants; Epilepsy; Female; Humans; Levetiracetam; Pregnancy; Seizures; Valproic Acid

2023
Potassium Channel Subfamily T Member 1(KCNT1) Pathological Variant Causing Epilepsy Of Infancy With Migrating Focal Seizures: A Case Report.
    JPMA. The Journal of the Pakistan Medical Association, 2023, Volume: 73, Issue:8

    Topics: Cyanosis; Epilepsy; Humans; Infant; Male; Nerve Tissue Proteins; Potassium Channels; Potassium Chann

2023
The prevalence and risk factors of coagulopathy in pediatric patients undergoing surgery for epilepsy.
    Journal of neurosurgery. Pediatrics, 2023, 11-01, Volume: 32, Issue:5

    Topics: Afibrinogenemia; Anticonvulsants; Blood Coagulation Disorders; Body Weight; Child; Epilepsy; Humans;

2023
The impact of a newly established specialized pediatric epilepsy center in Tanzania: An observational study.
    Epilepsy & behavior : E&B, 2023, Volume: 148

    Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Epilepsy; Humans; Phenobarbital; Tanzania; V

2023
Effect of digoxin, sodium valproate, and celecoxib on the cerebral cyclooxygenase pathway and neuron-specific enolase under the pentylenetetrazole-induced kindling in mice.
    Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 2023,Fall, Volume: 72, Issue:4

    Topics: Animals; Anticonvulsants; Celecoxib; Digoxin; Epilepsy; Mice; Neuroinflammatory Diseases; Pentylenet

2023
Cerebral and cerebellar pseudoatrophy associated with valproic acid. Report of three pediatric cases.
    Revista de neurologia, 2023, 10-16, Volume: 77, Issue:8

    Topics: Anticonvulsants; Brain; Brain Diseases; Cerebellum; Child; Child, Preschool; Epilepsy; Humans; Neuro

2023
Impact of
    Personalized medicine, 2023, Volume: 20, Issue:5

    Topics: Case-Control Studies; Cytochrome P-450 CYP2C9; Drug-Related Side Effects and Adverse Reactions; Epil

2023
Distribution pattern of UGT1A6 and UGT2B7 gene polymorphism and its impact on the pharmacokinetics of valproic acid and carbamazepine: Prospective genetic association study conducted in Pakistani patients with epilepsy.
    Gene, 2024, Jan-20, Volume: 892

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Epilepsy; Glucuronosyltransferase; Humans;

2024
Changes over 24 years in a pregnancy register - Teratogenicity and epileptic seizure control.
    Epilepsy & behavior : E&B, 2023, Volume: 148

    Topics: Anticonvulsants; Australia; Epilepsy; Female; Humans; Lamotrigine; Pregnancy; Pregnancy Complication

2023
Real-world practices for the care of women with epilepsy during pregnancy: A Canadian perspective.
    Epilepsy & behavior : E&B, 2023, Volume: 148

    Topics: Adult; Anticonvulsants; Canada; Epilepsy; Epilepsy, Generalized; Female; Humans; Pregnancy; Pregnanc

2023
Validity of Serum Zinc/Copper Ratio as a Potential Novel Biomarker in Childhood Epilepsy.
    Clinical laboratory, 2023, Nov-01, Volume: 69, Issue:11

    Topics: Anticonvulsants; Biomarkers; Child; Copper; Epilepsy; Humans; Levetiracetam; Oxcarbazepine; Valproic

2023
The Valproic Acid Dilemma: Safe Alternatives For Pregnant Women And Women Of Childbearing Age With Epilepsy.
    JPMA. The Journal of the Pakistan Medical Association, 2023, Volume: 73, Issue:11

    Topics: Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Pregnant Women; Valproic Acid

2023
Reducing birth defects in women with epilepsy: Research leading to results.
    Neurology, 2019, 08-27, Volume: 93, Issue:9

    Topics: Anticonvulsants; Epilepsy; Female; Humans; Valproic Acid

2019
Efficacy of phenobarbital and sodium valproate in treating convulsive epilepsy in rural northeast China.
    Seizure, 2019, Volume: 71

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; China; Epilepsy; Female; Follow-Up Stud

2019
Did advice on the prescription of sodium valproate reduce prescriptions to women? An observational study in three European countries between 2007 and 2016.
    Pharmacoepidemiology and drug safety, 2019, Volume: 28, Issue:11

    Topics: Adolescent; Adult; Anticonvulsants; Bipolar Disorder; Child; Cohort Studies; Databases, Factual; Epi

2019
Exome sequencing in patients with antiepileptic drug exposure and complex phenotypes.
    Archives of disease in childhood, 2020, Volume: 105, Issue:4

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child; Child, Preschool; Developmental Disabilities; E

2020
Elevated serum alkaline phosphatase in epilepsy: effect of age and treatment.
    British journal of biomedical science, 2020, Volume: 77, Issue:1

    Topics: Adolescent; Adult; Age Factors; Alkaline Phosphatase; Anticonvulsants; Carbamazepine; Child; Child,

2020
N-Benzyl-(2,5-dioxopyrrolidin-1-yl)propanamide (AS-1) with Hybrid Structure as a Candidate for a Broad-Spectrum Antiepileptic Drug.
    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2020, Volume: 17, Issue:1

    Topics: Animals; Anticonvulsants; Behavior, Animal; Dose-Response Relationship, Drug; Epilepsy; Ethosuximide

2020
Intestinal inflammation increases convulsant activity and reduces antiepileptic drug efficacy in a mouse model of epilepsy.
    Scientific reports, 2019, 09-27, Volume: 9, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Colitis; Convulsants; Dextran Sul

2019
[Epilepsy in children with congenital hemiparesis secondary to perinatal ictus].
    Medicina, 2019, Volume: 79 Suppl 3

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Infan

2019
Determination of unbound valproic acid in plasma using centrifugal ultrafiltration and gas chromatography:Application in TDM.
    Analytical biochemistry, 2020, 01-01, Volume: 588

    Topics: Adolescent; Child; Child, Preschool; Chromatography, Gas; Drug Monitoring; Epilepsy; Female; Humans;

2020
Perampanel-induced hair curling in a patient with epilepsy associated with Pitt Hopkins syndrome.
    Epileptic disorders : international epilepsy journal with videotape, 2019, Oct-01, Volume: 21, Issue:5

    Topics: Adolescent; Anticonvulsants; Epilepsy; Facies; Female; Hair; Humans; Hyperventilation; Intellectual

2019
Prevalence of valproate prescriptions in women of childbearing age in certain regions of Russia.
    Epilepsy & behavior : E&B, 2019, Volume: 101, Issue:Pt A

    Topics: Adolescent; Adult; Anticonvulsants; Cross-Sectional Studies; Drug Prescriptions; Epilepsy; Female; H

2019
A serious adverse drug reaction probably induced by clonazepam: a case report of myotoxicity.
    BMC pharmacology & toxicology, 2019, 11-05, Volume: 20, Issue:1

    Topics: Adult; Anticonvulsants; Clonazepam; Drug Therapy, Combination; Epilepsy; Female; Humans; Myotoxicity

2019
Prevalence and risk factors for hyponatremia in adult epilepsy patients: Large-scale cross-sectional cohort study.
    Seizure, 2019, Volume: 73

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Antipsychotic Agents; Benzodiazepines;

2019
Evaluation of sodium valproate loaded nanoparticles in acute and chronic pentylenetetrazole induced seizure models.
    Epilepsy research, 2019, Volume: 158

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Maze Learning; Oxidative Stress; Pentyle

2019
Cognitive performances in patients affected by late-onset epilepsy with unknown etiology: A 12-month follow-up study.
    Epilepsy & behavior : E&B, 2019, Volume: 101, Issue:Pt A

    Topics: Age of Onset; Aged; Aged, 80 and over; Anticonvulsants; Cognition; Epilepsy; Female; Follow-Up Studi

2019
De novo Absence Status Epilepticus in a pediatric cohort: Electroclinical pattern in a multicenter Italian patients cohort.
    Seizure, 2019, Volume: 73

    Topics: Adolescent; Anticonvulsants; Child; Electroencephalography; Epilepsy; Ethosuximide; Female; Humans;

2019
The role of isoaspartate in fibrillation and its prevention by Protein-L-isoaspartyl methyltransferase.
    Biochimica et biophysica acta. General subjects, 2020, Volume: 1864, Issue:3

    Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Anticonvulsants; Aspartic Acid; Benzothi

2020
Effects of valproic acid and levetiracetam monotherapy on carotid intima-media and epicardial adipose tissue thickness in non-obese children with epilepsy.
    Brain & development, 2020, Volume: 42, Issue:2

    Topics: Adipose Tissue; Anticonvulsants; Atherosclerosis; Body Mass Index; Carotid Arteries; Carotid Intima-

2020
Language impairment in children aged 5 and 8 years after antiepileptic drug exposure in utero - the Norwegian Mother and Child Cohort Study.
    European journal of neurology, 2020, Volume: 27, Issue:4

    Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cohort Studies; Epilepsy; Female; Humans; L

2020
Dried Blood Microsampling-Based Therapeutic Drug Monitoring of Antiepileptic Drugs in Children With Nodding Syndrome and Epilepsy in Uganda and the Democratic Republic of the Congo.
    Therapeutic drug monitoring, 2020, Volume: 42, Issue:3

    Topics: Anticonvulsants; Carbamazepine; Child; Chromatography, Liquid; Democratic Republic of the Congo; Dri

2020
[Confusional migraine in a young adult female: Is it a subtype of migraine with aura?]
    Rinsho shinkeigaku = Clinical neurology, 2020, Jan-30, Volume: 60, Issue:1

    Topics: Adult; Epilepsy; Female; Humans; Migraine Disorders; Topiramate; Valproic Acid; Young Adult

2020
Treatment decisions in women of childbearing age on valproate.
    Acta neurologica Scandinavica, 2020, Volume: 141, Issue:4

    Topics: Adult; Anticonvulsants; Decision Making; Epilepsy; Female; Humans; Informed Consent; Patient Educati

2020
Exploring the ameliorative role of α7 neuronal nicotinic acetylcholine receptor modulation in epilepsy and associated comorbidities in post-PTZ-kindled mice.
    Epilepsy & behavior : E&B, 2020, Volume: 103, Issue:Pt A

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anticonvulsants; Corticosterone; Depression; Dose-

2020
Evaluation of Cardiac Repolarization Indices in Epilepsy Patients Treated with Carbamazepine and Valproic Acid.
    Medicina (Kaunas, Lithuania), 2020, Jan-06, Volume: 56, Issue:1

    Topics: Adolescent; Adult; Carbamazepine; Cross-Sectional Studies; Electrocardiography; Epilepsy; Female; He

2020
ATP1A3-related epilepsy: Report of seven cases and literature-based analysis of treatment response.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2020, Volume: 72

    Topics: Adult; Anticonvulsants; Cerebellar Ataxia; Child; Dystonic Disorders; Epilepsy; Female; Hearing Loss

2020
Downregulation of peripheral PTGS2/COX-2 in response to valproate treatment in patients with epilepsy.
    Scientific reports, 2020, 02-13, Volume: 10, Issue:1

    Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Cyclooxygenase

2020
Valproic acid associated pleuropericardial effusion: case report.
    Ideggyogyaszati szemle, 2020, Jan-30, Volume: 73, Issue:1-2

    Topics: Anticonvulsants; Epilepsy; Female; Humans; Pericardial Effusion; Pleural Effusion; Valproic Acid; Yo

2020
Valproate risk form-Surveying 215 clinicians involving 4775 encounters.
    Acta neurologica Scandinavica, 2020, Volume: 141, Issue:6

    Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam; Physicians

2020
Effects of Sodium Valproate Combined with Lamotrigine on Quality of Life and Serum Inflammatory Factors in Patients with Poststroke Secondary Epilepsy.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2020, Volume: 29, Issue:5

    Topics: Aged; Anticonvulsants; Biomarkers; Brain; Case-Control Studies; Down-Regulation; Drug Therapy, Combi

2020
Impact of Age and Genotype on Serum Concentrations of Valproic Acid and Its Hepatotoxic Metabolites in Chinese Pediatric Patients With Epilepsy.
    Therapeutic drug monitoring, 2020, Volume: 42, Issue:5

    Topics: Adolescent; Anticonvulsants; Asian People; Child; Child, Preschool; Epilepsy; Female; Genotype; Gluc

2020
Evaluation of adverse drug reaction profile of antiepileptic drugs in persons with epilepsy: A cross-sectional study.
    Epilepsy & behavior : E&B, 2020, Volume: 105

    Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Child; Cross-Sectional Studies; Drug-Related Si

2020
Testing association of rare genetic variants with resistance to three common antiseizure medications.
    Epilepsia, 2020, Volume: 61, Issue:4

    Topics: Anticonvulsants; Case-Control Studies; Drug Resistance; Epilepsy; Female; Genotype; Humans; Lamotrig

2020
Analysis of antiseizure drug-related adverse reactions from the electronic health record using the common data model.
    Epilepsia, 2020, Volume: 61, Issue:4

    Topics: Anticonvulsants; Common Data Elements; Drug-Related Side Effects and Adverse Reactions; Electronic H

2020
Association of SCN1A, SCN2A, and UGT2B7 Polymorphisms with Responsiveness to Valproic Acid in the Treatment of Epilepsy.
    BioMed research international, 2020, Volume: 2020

    Topics: Adult; Asian People; Epilepsy; Female; Genotype; Glucuronosyltransferase; Humans; Male; NAV1.1 Volta

2020
Vaccination management in an asymptomatic child with a novel SCN1A variant and family history of status epilepticus following vaccination: A case report on a potential new direction in personalised medicine.
    Seizure, 2020, Volume: 78

    Topics: Anticonvulsants; Clobazam; Enterovirus A, Human; Enterovirus Infections; Epilepsy; Fatal Outcome; Fe

2020
Effects of carbamazepine, eslicarbazepine, valproic acid and levetiracetam on bone microarchitecture in rats.
    Pharmacological reports : PR, 2020, Volume: 72, Issue:5

    Topics: Animals; Anticonvulsants; Bone and Bones; Carbamazepine; Dibenzazepines; Disease Models, Animal; Epi

2020
Evolution of Epileptiform Activity in Zebrafish by Statistical-Based Integration of Electrophysiology and 2-Photon Ca
    Cells, 2020, 03-21, Volume: 9, Issue:3

    Topics: Action Potentials; Animals; Calcium; Electrophysiological Phenomena; Epilepsy; Female; Humans; Male;

2020
Improvement of epilepsy with lacosamide in a patient with ring chromosome 20 syndrome.
    Brain & development, 2020, Volume: 42, Issue:6

    Topics: Anticonvulsants; Carbamazepine; Child; Electroencephalography; Epilepsy; Humans; Lacosamide; Lamotri

2020
Influence of age and co-medication on the concentration and efficacy of valproic acid in Chinese epilepsy children.
    Pakistan journal of pharmaceutical sciences, 2020, Volume: 33, Issue:2

    Topics: Adolescent; Age Factors; Anticonvulsants; Asian People; Child; Child, Preschool; Drug Therapy, Combi

2020
Impact of the EMA/FDA alerts on the use of effective contraceptive method in women of childbearing age undergoing valproic acid treatment in a long-stay psychiatric center.
    Epilepsy & behavior : E&B, 2020, Volume: 107

    Topics: Adult; Anticonvulsants; Contraception; Drug and Narcotic Control; Drug Labeling; Epilepsy; Europe; F

2020
Pregnancy after valproate withdrawal-Fetal malformations and seizure control.
    Epilepsia, 2020, Volume: 61, Issue:5

    Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Australia; Epilepsy; Female; Humans; Pregnancy;

2020
Rufinamide as add-on therapy in children with epileptic encephalopathies other than Lennox-Gastaut syndrome: A study of 34 patients.
    Epilepsy & behavior : E&B, 2020, Volume: 108

    Topics: Adolescent; Anticonvulsants; Argentina; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy

2020
Serum Levels of Valproic Acid and Carbamazepine Do Not Correlate Well with End-Organ Dysfunction.
    Epilepsy research, 2020, Volume: 163

    Topics: Adolescent; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Child, Preschool; Drug Therapy,

2020
Reply to Calabrò: Towards a better understanding of valproate induced sexual and reproductive dysfunction in men with epilepsy.
    Epilepsy & behavior : E&B, 2020, Volume: 109

    Topics: Anticonvulsants; Epilepsy; Humans; Male; Sexual Behavior; Sexual Health; Valproic Acid

2020
Effects of valproate, carbamazepine and levetiracetam on Tp-e interval, Tp-e/QT and Tp-e/QTc ratio.
    Ideggyogyaszati szemle, 2020, Mar-30, Volume: 73, Issue:3-4

    Topics: Adult; Anticonvulsants; Arrhythmias, Cardiac; Carbamazepine; Case-Control Studies; Electrocardiograp

2020
Treating women of reproductive age with valproate.
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2020, 05-05, Volume: 140, Issue:7

    Topics: Anticonvulsants; Epilepsy; Female; Humans; Valproic Acid

2020
The impact and challenges of the 2018 MHRA statement on the use of sodium valproate in women of childbearing age during the first year of implementation, in a UK epilepsy centre.
    Seizure, 2020, Volume: 79

    Topics: Adolescent; Adult; Anticonvulsants; Contraception; Contraindications, Drug; Cross-Sectional Studies;

2020
Effects of Diclofenac Versus Meloxicam in Pentylenetetrazol-Kindled Mice.
    Neurochemical research, 2020, Volume: 45, Issue:8

    Topics: Animals; Anticonvulsants; Diclofenac; Epilepsy; Kindling, Neurologic; Male; Meloxicam; Mice; Pentyle

2020
Towards a better understanding of valproate-induced sexual and reproductive dysfunction in men with epilepsy.
    Epilepsy & behavior : E&B, 2020, Volume: 109

    Topics: Anticonvulsants; Epilepsy; Humans; Male; Sexual Behavior; Sexual Health; Valproic Acid

2020
Association Between the Serum Carnitine Level and Ammonia and Valproic Acid Levels in Patients with Bipolar Disorder.
    Therapeutic drug monitoring, 2020, Volume: 42, Issue:5

    Topics: Ammonia; Anticonvulsants; Bipolar Disorder; Carnitine; Epilepsy; Female; Humans; Male; Middle Aged;

2020
Autophagy associated with the efficacy of valproic acid in PTZ-induced epileptic rats.
    Brain research, 2020, 10-15, Volume: 1745

    Topics: Animals; Anticonvulsants; Autophagy; Convulsants; Drug Resistance; Epilepsy; Male; Pentylenetetrazol

2020
Sub-additive (antagonistic) interaction of lacosamide with lamotrigine and valproate in the maximal electroshock-induced seizure model in mice: an isobolographic analysis.
    Pharmacological reports : PR, 2020, Volume: 72, Issue:5

    Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Drug

2020
Effects of antiepileptic drugs on electroencephalography (EEG): Insights and applicability.
    Epilepsy & behavior : E&B, 2020, Volume: 110

    Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Carbamazepine; Electroencephalography; Epilepsy

2020
Dosing Recommendations Based on Population Pharmacokinetics of Lamotrigine in Mexican Adult Patients With Epilepsy.
    Journal of pharmaceutical sciences, 2020, Volume: 109, Issue:9

    Topics: Adult; Anticonvulsants; Epilepsy; Humans; Lamotrigine; Triazines; Valproic Acid

2020
What about children treated with valproate?
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2020, 06-16, Volume: 140, Issue:9

    Topics: Anticonvulsants; Child; Epilepsy; Humans; Valproic Acid

2020
Pharmacokinetic Variability During Long-Term Therapeutic Drug Monitoring of Valproate, Clobazam, and Levetiracetam in Patients With Dravet Syndrome.
    Therapeutic drug monitoring, 2020, Volume: 42, Issue:5

    Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Dioxolanes;

2020
Is the Medicines and Healthcare products Regulator Agency (MHRA) guidance on sodium valproate acceptable to women of childbearing age?
    The journal of the Royal College of Physicians of Edinburgh, 2020, Volume: 50, Issue:2

    Topics: Anticonvulsants; Delivery of Health Care; Epilepsy; Female; Government Agencies; Humans; Pregnancy;

2020
Factors associated with depression in people with epilepsy: a retrospective case-control analysis.
    Hong Kong medical journal = Xianggang yi xue za zhi, 2020, Volume: 26, Issue:4

    Topics: Adult; Anticonvulsants; Case-Control Studies; Clonazepam; Depression; Epilepsy; Female; Humans; Male

2020
Thrombocytopenia in pediatric patients on concurrent cannabidiol and valproic acid.
    Epilepsia, 2020, Volume: 61, Issue:8

    Topics: Adolescent; Anticonvulsants; Cannabidiol; Child; Child, Preschool; Drug Resistant Epilepsy; Drug The

2020
Remedial dosing recommendations for delayed or missed doses of valproic acid in patients with epilepsy based on Monte Carlo simulations.
    Epilepsy & behavior : E&B, 2020, Volume: 111

    Topics: Adult; Aged; Anticonvulsants; Child; Child, Preschool; Drug Administration Schedule; Epilepsy; Femal

2020
Valproic acid and zonisamide induced hyperammonemic encephalopathy.
    Clinical neurology and neurosurgery, 2020, Volume: 196

    Topics: Adult; Anticonvulsants; Brain; Brain Diseases; Epilepsy; Humans; Hyperammonemia; Magnetic Resonance

2020
SLC6A1 G443D associated with developmental delay and epilepsy.
    Cold Spring Harbor molecular case studies, 2020, Volume: 6, Issue:4

    Topics: Child, Preschool; Developmental Disabilities; Epilepsy; Female; GABA Plasma Membrane Transport Prote

2020
Antiepileptic combination therapy with Stevens-Johnson syndrome and toxic epidermal necrolysis: Analysis of a Japanese pharmacovigilance database.
    Epilepsia, 2020, Volume: 61, Issue:9

    Topics: Anticonvulsants; Carbamazepine; Clobazam; Clonazepam; Databases, Factual; Drug Therapy, Combination;

2020
Sleep Architecture in Valproate-Induced Nocturnal Enuresis in Primary School and Preschool Children.
    Journal of child neurology, 2020, Volume: 35, Issue:14

    Topics: Age Factors; Arousal; Brain; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Nocturnal Enur

2020
Metabolic syndrome and obstructive sleep apnea syndrome among patients with epilepsy on monotherapy.
    Epilepsy & behavior : E&B, 2020, Volume: 111

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Cross-Sectional Studies; Epilepsy; Female;

2020
[Dynamics of epileptiform activity, efficacy and tolerability of valproic acid in adults and adolescents with newly-diagnosed epilepsy].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2020, Volume: 120, Issue:7

    Topics: Adolescent; Adult; Anticonvulsants; Electroencephalography; Epilepsies, Partial; Epilepsy; Epilepsy,

2020
Valproate prescribing practices for women with intellectual disability across Europe.
    Acta neurologica Scandinavica, 2021, Volume: 143, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Drug Prescriptions; Epilepsy; Europe; Female; Humans; Intellectu

2021
Understanding and Responding to Prescribing Patterns of Sodium Valproate-Containing Medicines in Pregnant Women and Women of Childbearing Age in Western Cape, South Africa.
    Drug safety, 2021, Volume: 44, Issue:1

    Topics: Epilepsy; Female; Humans; Practice Patterns, Physicians'; Pregnancy; Pregnant Women; South Africa; V

2021
Impact of CYP2C19 and CYP2C9 gene polymorphisms on sodium valproate plasma concentration in patients with epilepsy.
    European journal of hospital pharmacy : science and practice, 2022, Volume: 29, Issue:4

    Topics: Aryl Hydrocarbon Hydroxylases; China; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Epilepsy; H

2022
Safety range of free valproic acid serum concentration in adult patients.
    PloS one, 2020, Volume: 15, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Dosage Forms; Dose-Response Relationship, Drug; Dru

2020
Valproic acid concentration and biochemical indexes in epilepsy outpatients during monotherapy or combination therapy.
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2020, Jul-28, Volume: 45, Issue:7

    Topics: Adolescent; Anticonvulsants; Combined Modality Therapy; Drug Therapy, Combination; Epilepsy; Humans;

2020
Trends of anti-seizure medication use in pediatric patients in six cities in China from 2013 to 2018.
    Epilepsy research, 2020, Volume: 167

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; China; Epilepsy; Female; Humans

2020
Risk-benefit assessment of treatment of epileptic women of childbearing age with valproic acid.
    Seizure, 2020, Volume: 82

    Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Humans; Middle Aged; Pregnancy; Risk Assessmen

2020
First do no harm: valproate and medicines safety in pregnancy.
    The British journal of general practice : the journal of the Royal College of General Practitioners, 2020, Volume: 70, Issue:699

    Topics: Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complications; Valproic Acid

2020
    International journal of clinical pharmacology and therapeutics, 2021, Volume: 59, Issue:1

    Topics: Anticonvulsants; Carbamazepine; Cytochrome P-450 CYP3A; Epilepsy; Humans; Malaysia; Valproic Acid

2021
Risk of early neurodevelopmental disorders associated with in utero exposure to valproate and other antiepileptic drugs: a nationwide cohort study in France.
    Scientific reports, 2020, 10-22, Volume: 10, Issue:1

    Topics: Adult; Anticonvulsants; Child, Preschool; Cohort Studies; Dose-Response Relationship, Drug; Epilepsy

2020
Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children.
    Epilepsy research, 2020, Volume: 168

    Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Genotype; Humans; Male; NAV1.1 Voltage-G

2020
Ex vivo radiosensitivity is increased in non-cancer patients taking valproate.
    BMC neurology, 2020, Oct-24, Volume: 20, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Cells, Cultured; Cohort Studies; Epilepsy; Female;

2020
Antiseizure medication use during pregnancy and risk of ASD and ADHD in children.
    Neurology, 2020, 12-15, Volume: 95, Issue:24

    Topics: Adolescent; Adult; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Autism Spectrum D

2020
Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Intellectual Disability and Delayed Childhood Milestones.
    JAMA network open, 2020, 11-02, Volume: 3, Issue:11

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Denmark; Developmen

2020
Clinical and Kinematic Features of Valproate-Induced Tremor and Differences with Essential Tremor.
    Cerebellum (London, England), 2021, Volume: 20, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Biomechanical Phenomena; Diagnosis, Differential; E

2021
Effects of valproate, lamotrigine, and levetiracetam monotherapy on bone health in newly diagnosed adult patients with epilepsy.
    Epilepsy & behavior : E&B, 2020, Volume: 113

    Topics: Adult; Anticonvulsants; Bone Density; Epilepsy; Humans; Lamotrigine; Levetiracetam; Triazines; Valpr

2020
The correlation between carbamazepine and valproic acid monotherapy with serum adiponectin and carnitine.
    Acta neurologica Belgica, 2021, Volume: 121, Issue:6

    Topics: Adiponectin; Adult; Anticonvulsants; Biomarkers; Carbamazepine; Carnitine; Dose-Response Relationshi

2021
Evaluation of the Protective Effect of Ademetionine, Cytoflavin, and Dihydroquercetetine on Blood Enzymes Activity in Rats Treated with High Doses of Sodium Valproate.
    Bulletin of experimental biology and medicine, 2020, Volume: 170, Issue:2

    Topics: Alkaline Phosphatase; Animals; Anticonvulsants; Drug Combinations; Epilepsy; Erythrocytes; Flavin Mo

2020
Metformin, valproic acid, and starvation induce seizures in a patient with partial SLC13A5 deficiency: a case of pharmaco-synergistic heterozygosity.
    Psychiatric genetics, 2021, 02-01, Volume: 31, Issue:1

    Topics: Adult; Amino Acid Substitution; Ammonia; Animals; Anticonvulsants; Autistic Disorder; Bipolar Disord

2021
Determination of healthcare resource and cost implications of using alternative sodium valproate formulations in the treatment of epilepsy in children in England: A retrospective database review.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2021, Volume: 158

    Topics: Administrative Claims, Healthcare; Adolescent; Child; Child, Preschool; Cost Savings; Datasets as To

2021
An open study of valproate in subfertile men with epilepsy.
    Acta neurologica Scandinavica, 2020, Volume: 142, Issue:4

    Topics: Adult; Anticonvulsants; Drug Substitution; Epilepsy; Female; Greece; Humans; Infertility, Male; Lamo

2020
Real-world prescribing trends of valproate in women with epilepsy in Korea.
    Epilepsy & behavior : E&B, 2021, Volume: 115

    Topics: Anticonvulsants; Epilepsy; Female; Humans; Republic of Korea; Valproic Acid

2021
Population pharmacokinetics of unbound valproic acid in pediatric epilepsy patients in China: a protein binding model.
    European journal of clinical pharmacology, 2021, Volume: 77, Issue:7

    Topics: Adolescent; Anticonvulsants; Body Weight; Child; Child, Preschool; China; Drug Dosage Calculations;

2021
Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats.
    Journal of ethnopharmacology, 2021, Apr-24, Volume: 270

    Topics: Adjuvants, Pharmaceutic; Animals; Anticonvulsants; Behavior, Animal; Centella; Cognitive Dysfunction

2021
Acute and chronic treatment with moclobemide, a reversible MAO-inhibitor, potentiates the antielectroshock activity of conventional antiepileptic drugs in mice.
    Pharmacology, biochemistry, and behavior, 2021, Volume: 201

    Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship,

2021
Valproic acid and socioeconomic associations in Swedish women with epilepsy 2010-2015.
    Acta neurologica Scandinavica, 2021, Volume: 143, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Cohort Studies; Drug Prescriptions; Educational Status; Epilepsy

2021
Prenatal valproate exposure and adverse neurodevelopmental outcomes: Does sex matter?
    Epilepsia, 2021, Volume: 62, Issue:3

    Topics: Anticonvulsants; Autism Spectrum Disorder; Case-Control Studies; Child; Child, Preschool; Dose-Respo

2021
Knowledge of epilepsy among German pharmacists.
    Epilepsy research, 2021, Volume: 172

    Topics: Anticonvulsants; Carbamazepine; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Humans; L

2021
The effects of valproate on serum leptin, insulin, and lipid levels in epileptic children.
    Pediatrics international : official journal of the Japan Pediatric Society, 2021, Volume: 63, Issue:11

    Topics: Anticonvulsants; Child; Epilepsy; Humans; Insulin; Leptin; Valproic Acid

2021
Thinking out of the box: management of valproic acid toxicity with carbapenems.
    BMJ case reports, 2021, Mar-10, Volume: 14, Issue:3

    Topics: Adult; Anticonvulsants; Carbapenems; Carnitine; Epilepsy; Female; Humans; Meropenem; Valproic Acid

2021
Carnitine supplementation prevents carnitine deficiency caused by pivalate-conjugated antibiotics in patients with epilepsy prescribed valproate.
    Epilepsy & behavior : E&B, 2021, Volume: 117

    Topics: Anti-Bacterial Agents; Carnitine; Dietary Supplements; Epilepsy; Humans; Valproic Acid

2021
Epigenetic evidence of an Ac/Dc axis by VPA and SAHA.
    Clinical epigenetics, 2021, 03-20, Volume: 13, Issue:1

    Topics: Acetylation; Cells, Cultured; Epigenesis, Genetic; Epilepsy; Gene Expression Regulation; Histone Dea

2021
Valproate usage in pregnancy: An audit from the Kerala Registry of Epilepsy and Pregnancy.
    Epilepsia, 2021, Volume: 62, Issue:5

    Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Epilepsy; Female; Humans; India; Pregnancy; Pre

2021
Effects of antiepileptic drugs' administration during pregnancy on the nerve cell proliferation and axonal outgrowth of human neuroblastoma SH-SY5Y nerve cells.
    Biochemical and biophysical research communications, 2021, 05-21, Volume: 554

    Topics: Anticonvulsants; Carbamazepine; Cell Line, Tumor; Cell Proliferation; Child; Epilepsy; Female; Human

2021
Response to first antiseizure medication in patients diagnosed with epilepsy.
    Acta neurologica Scandinavica, 2021, Volume: 144, Issue:1

    Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Cohort Studies; Epilepsy; Female; Follow-Up Studies; Hu

2021
The contribution of non-drug factors to fetal malformation in anti-seizure-medication-treated pregnancy.
    Epilepsy & behavior : E&B, 2021, Volume: 118

    Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Australia; Epilepsy; Female; Humans; Pregnancy;

2021
Valproate but not levetiracetam slows the EEG alpha peak frequency - A pharmaco-EEG study.
    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2021, Volume: 132, Issue:6

    Topics: Adolescent; Adult; Aged; Alpha Rhythm; Anticonvulsants; Brain; Child; Electroencephalography; Epilep

2021
Effects of antiseizure monotherapy on visuospatial memory in pediatric age.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2021, Volume: 32

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Ethosuximide; Executive Function; Femal

2021
Predictors of successful valproate withdrawal in women with epilepsy.
    Epilepsy & behavior : E&B, 2021, Volume: 119

    Topics: Anticonvulsants; Epilepsy; Epilepsy, Generalized; Female; Humans; Levetiracetam; Valproic Acid

2021
Valproic acid use in fertile women with genetic generalized epilepsies.
    Acta neurologica Scandinavica, 2021, Volume: 144, Issue:3

    Topics: Anticonvulsants; Epilepsy; Epilepsy, Generalized; Female; Humans; Infant, Newborn; Male; Retrospecti

2021
Influence of
    Xenobiotica; the fate of foreign compounds in biological systems, 2021, Volume: 51, Issue:7

    Topics: Anticonvulsants; Child; China; Epilepsy; Glucuronosyltransferase; Humans; Polymorphism, Single Nucle

2021
Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children: A protocol for systematic review and meta-analysis.
    Medicine, 2021, May-21, Volume: 100, Issue:20

    Topics: Anticonvulsants; Child; Drug Resistance; Electroencephalography; Epilepsy; Humans; Meta-Analysis as

2021
Post-stroke epilepsy and antiepileptic drug use in men and women.
    Basic & clinical pharmacology & toxicology, 2021, Volume: 129, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Lamotrigin

2021
Treatment effects of the combination of ceftriaxone and valproic acid on neuronal and behavioural functions in a rat model of epilepsy.
    Experimental physiology, 2021, Volume: 106, Issue:8

    Topics: Animals; Ceftriaxone; Epilepsy; Male; Neurons; Rats; Rats, Wistar; Valproic Acid

2021
Contemporary trends in antiepileptic drug treatment among women of childbearing age with epilepsy in the United States: 2004-2015.
    Journal of the neurological sciences, 2021, 08-15, Volume: 427

    Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Pregnancy

2021
CNKSR2 gene mutation leads to Houge type of X-linked syndromic mental retardation: A case report and review of literature.
    Medicine, 2021, Jun-11, Volume: 100, Issue:23

    Topics: Adaptor Proteins, Signal Transducing; Anticonvulsants; Child; Codon, Nonsense; Epilepsy; Humans; Int

2021
Association of UGT1A6 gene polymorphism with clinical outcome in pediatric epileptic patients on sodium valproate monotherapy.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2021, Volume: 54, Issue:9

    Topics: Anticonvulsants; Child; Epilepsy; Humans; Polymorphism, Single Nucleotide; Seizures; Valproic Acid

2021
Histopathological and Biochemical Assessment of Neuroprotective Effects of Sodium Valproate and Lutein on the Pilocarpine Albino Rat Model of Epilepsy.
    Behavioural neurology, 2021, Volume: 2021

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Humans; Lutein; Neuroprotective Agents;

2021
Factors associated with blood carnitine levels in adult epilepsy patients with chronic valproic acid therapy.
    Epilepsy research, 2021, Volume: 175

    Topics: Adult; Amino Acids; Anticonvulsants; Carnitine; Epilepsy; Humans; Valproic Acid

2021
Epileptic convulsions probably induced by desloratadine: a case report.
    European journal of hospital pharmacy : science and practice, 2023, Volume: 30, Issue:4

    Topics: Anticonvulsants; Child; Epilepsy; Humans; Male; Seizures; Valproic Acid

2023
Post-stroke seizures: risk factors and management after ischemic stroke.
    Acta neurologica Belgica, 2023, Volume: 123, Issue:1

    Topics: Aged; Epilepsy; Female; Humans; Infarction, Middle Cerebral Artery; Ischemic Stroke; Male; Middle Ag

2023
Plasma brain natriuretic peptide levels in children with idiopathic epilepsy treated with longterm sodium valproate and oxcarbazepine monotherapy.
    Journal of biological regulators and homeostatic agents, 2021, Aug-27, Volume: 35, Issue:4

    Topics: Anticonvulsants; Child; Epilepsy; Humans; Natriuretic Peptide, Brain; Oxcarbazepine; Valproic Acid

2021
A Comparative Study of the Effects of Valproate and Oxcarbazepine on Sexual Function, Sperm Quality, and Sex Hormones in Males with Epilepsy.
    BioMed research international, 2021, Volume: 2021

    Topics: Adult; Case-Control Studies; Epilepsy; Gonadal Steroid Hormones; Humans; Male; Oxcarbazepine; Sperma

2021
Management of bone metabolism in epilepsy.
    Ideggyogyaszati szemle, 2021, Jul-30, Volume: 74, Issue:7-08

    Topics: Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Male; Retrospective Studies; Valproic Acid

2021
Effects of l-carnitine supplementation in patients with childhood-onset epilepsy prescribed valproate.
    Epilepsy & behavior : E&B, 2021, Volume: 122

    Topics: Carnitine; Child; Dietary Supplements; Epilepsy; Humans; Retrospective Studies; Valproic Acid

2021
The Relationship Between Valproate and Lamotrigine/Levetiracetam Use and Prognosis in Patients With Epilepsy and Heart Failure: A Danish Register-Based Study.
    Journal of cardiac failure, 2022, Volume: 28, Issue:4

    Topics: Aged; Anticonvulsants; Cohort Studies; Denmark; Epilepsy; Heart Failure; Humans; Lamotrigine; Leveti

2022
Association of CYP2C9, CYP2A6, ACSM2A, and CPT1A gene polymorphisms with adverse effects of valproic acid in Chinese patients with epilepsy.
    Epilepsy research, 2017, Volume: 132

    Topics: Anticonvulsants; Asian People; Carnitine O-Palmitoyltransferase; Coenzyme A Ligases; Cytochrome P-45

2017
Influence of age and co-medication on the steady-state pharmacokinetics of valproic acid in Tunisian patients with epilepsy.
    Revue neurologique, 2017, Volume: 173, Issue:3

    Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Child, Preschool; Drug Interactions; Drug Mo

2017
Assessment of atherosclerotic risk among patients with epilepsy on valproic acid, lamotrigine, and carbamazepine treatment.
    Neurosciences (Riyadh, Saudi Arabia), 2017, Volume: 22, Issue:2

    Topics: Adult; Anticonvulsants; Carbamazepine; Cholesterol; Cross-Sectional Studies; Epilepsy; Female; Human

2017
Monitoring Protein-Unbound Valproic Acid Serum Concentrations in Clinical Practice.
    Therapeutic drug monitoring, 2017, Volume: 39, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Blood Proteins; Child; Drug Monitoring;

2017
A Long-Term Treatment with Arachidonyl-2'-Chloroethylamide Combined with Valproate Increases Neurogenesis in a Mouse Pilocarpine Model of Epilepsy.
    International journal of molecular sciences, 2017, Apr-25, Volume: 18, Issue:5

    Topics: Animals; Anticonvulsants; Arachidonic Acids; Astrocytes; Disease Models, Animal; Drug Therapy, Combi

2017
The remarkable story of valproic acid.
    The Lancet. Neurology, 2016, Volume: 15, Issue:2

    Topics: Anticonvulsants; Epilepsy; History, 20th Century; Humans; Valproic Acid

2016
Population Pharmacokinetics of Valproic Acid in Patients with Mania: Implication for Individualized Dosing Regimens.
    Clinical therapeutics, 2017, Volume: 39, Issue:6

    Topics: Adolescent; Adult; Aged; Antimanic Agents; Bipolar Disorder; Body Weight; Drug Monitoring; Epilepsy;

2017
Contraception advice for women with epilepsy.
    BMJ (Clinical research ed.), 2017, 05-11, Volume: 357

    Topics: Adult; Contraception Behavior; Contraceptive Agents; Counseling; Drug Interactions; Epilepsy; Family

2017
Burst Suppression Pattern on Electroencephalogram Secondary to Valproic Acid-Induced Hyperammonemic Encephalopathy.
    Pediatric neurology, 2017, Volume: 73

    Topics: Adolescent; Anticonvulsants; Autistic Disorder; Brain Diseases; Electroencephalography; Epilepsy; Fe

2017
Clinical Importance of Monitoring Unbound Valproic Acid Concentration in Patients with Hypoalbuminemia.
    Pharmacotherapy, 2017, Volume: 37, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Drug Monitoring; Epilepsy; Female; Humans; Hypoalbu

2017
The influence of levetiracetam on psychosocial and behavioral functioning in children: A case-control and follow-up study.
    Epilepsy & behavior : E&B, 2017, Volume: 72

    Topics: Adolescent; Anticonvulsants; Case-Control Studies; Child; Child Behavior; Epilepsy; Female; Follow-U

2017
Patterns of antiepileptic drug prescription in Sweden: A register-based approach.
    Acta neurologica Scandinavica, 2017, Volume: 136, Issue:5

    Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Drug Prescriptions; Epilepsy; Female; Humans; Lamotrigi

2017
Analysis of the Variables Influencing Valproic Acid Concentration in the Serum and Cerebrospinal Fluid of Chinese Patients After Craniotomy.
    Therapeutic drug monitoring, 2017, Volume: 39, Issue:4

    Topics: Aged; Asian People; Craniotomy; Cytochrome P-450 CYP2C9; Epilepsy; Female; Humans; Male; Middle Aged

2017
Effect of ketogenic diet and other dietary therapies on anti-epileptic drug concentrations in patients with epilepsy.
    Journal of clinical pharmacy and therapeutics, 2017, Volume: 42, Issue:6

    Topics: Adolescent; Anticonvulsants; Biological Availability; Child; Child, Preschool; Diet, Ketogenic; Dose

2017
The impact of valproic acid treatment on weight gain in pediatric patients with epilepsy.
    Minerva pediatrics, 2022, Volume: 74, Issue:4

    Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Seizures; Valproic Acid; W

2022
Inattention and Poor Eye Contact Is Not All Autism.
    Clinical pediatrics, 2017, Volume: 56, Issue:9

    Topics: Anticonvulsants; Autism Spectrum Disorder; Child; Diagnosis, Differential; Electroencephalography; E

2017
N-alkyl-[1,1'-biphenyl]-2-sulfonamide derivatives as novel broad spectrum anti-epileptic drugs with efficacy equivalent to that of sodium valproate.
    Bioorganic & medicinal chemistry letters, 2017, 09-01, Volume: 27, Issue:17

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Mice;

2017
Genetic polymorphisms and valproic acid plasma concentration in children with epilepsy on valproic acid monotherapy.
    Seizure, 2017, Volume: 51

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Glucuronosyltransferase; Hum

2017
Clinical study on anti-epileptic drug with B vitamins for the treatment of epilepsy after stroke.
    European review for medical and pharmacological sciences, 2017, Volume: 21, Issue:14

    Topics: Adult; Aged; Anticonvulsants; Epilepsy; Female; Humans; Male; Middle Aged; Stroke; Valproic Acid; Vi

2017
Thrombotic microangiopathy associated with Valproic acid toxicity.
    BMC nephrology, 2017, Aug-03, Volume: 18, Issue:1

    Topics: Adolescent; Anticonvulsants; Epilepsy; Humans; Male; Thrombotic Microangiopathies; Valproic Acid

2017
Pharmacokinetic variability of valproate in women of childbearing age.
    Epilepsia, 2017, Volume: 58, Issue:10

    Topics: Adolescent; Adult; Anticonvulsants; Drug Monitoring; Epilepsy; Female; Humans; Middle Aged; Norway;

2017
Risk factors for sodium valproate-induced renal tubular dysfunction.
    Clinical and experimental nephrology, 2018, Volume: 22, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; beta 2-Microglobulin; Biomarkers; Carnitine; Chi-Square Distribu

2018
Pharmacokinetic and pharmacodynamic interaction of hydroalcoholic extract of Ocimum sanctum with valproate.
    Epilepsy & behavior : E&B, 2017, Volume: 75

    Topics: Animals; Anticonvulsants; Antioxidants; Avoidance Learning; Cognition; Disease Models, Animal; Drug

2017
Melatonin and Hippo Pathway: Is There Existing Cross-Talk?
    International journal of molecular sciences, 2017, 09-06, Volume: 18, Issue:9

    Topics: Animals; Antioxidants; Circadian Rhythm; Epilepsy; Humans; Melatonin; Protein Serine-Threonine Kinas

2017
Decreased platelet count in children with epilepsy treated with valproate and its relationship to the immature platelet fraction.
    International journal of hematology, 2018, Volume: 107, Issue:1

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Flow Cytometry; Humans; Infa

2018
[Bone metabolism disorders caused by sodium valproate therapy in children with epilepsy and the prevention of the disorders by supplementation of calcium and vitamin D].
    Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2017, Volume: 19, Issue:9

    Topics: Adolescent; Anticonvulsants; Bone and Bones; Calcium; Calcium, Dietary; Child; Child, Preschool; Die

2017
Women still not being told about pregnancy risks of valproate.
    BMJ (Clinical research ed.), 2017, 09-22, Volume: 358

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Developmental Disabilities; Epilepsy; Female; Humans;

2017
Correlations between UGT2B7∗2 gene polymorphisms and plasma concentrations of carbamazepine and valproic acid in epilepsy patients.
    Brain & development, 2018, Volume: 40, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Child; Child, Preschool;

2018
Effects of Carbamazepine and Valproate on Serum Aspartate Aminotransferase, Alanine Aminotransferase and Gamma - Glutamyltransferase in Children.
    Medical archives (Sarajevo, Bosnia and Herzegovina), 2017, Volume: 71, Issue:4

    Topics: Adolescent; Alanine Transaminase; Anticonvulsants; Aspartate Aminotransferases; Carbamazepine; Child

2017
Two gaps too many, three clues too few? Do elevated osmolal and anion gaps with crystalluria always mean ethylene glycol poisoning?
    BMJ case reports, 2017, Oct-15, Volume: 2017

    Topics: Acid-Base Equilibrium; Acidosis; Anticonvulsants; Brain Diseases; Calcium Oxalate; Cognitive Dysfunc

2017
Fetal Valproate Syndrome - Still a Problem Today!
    Zeitschrift fur Geburtshilfe und Neonatologie, 2017, Volume: 221, Issue:5

    Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Cesarean Section; Drug Therapy, Combination; Ep

2017
Sotalol enhances the anticonvulsant action of valproate and diphenylhydantoin in the mouse maximal electroshock model.
    Pharmacological reports : PR, 2017, Volume: 69, Issue:6

    Topics: Animals; Anti-Arrhythmia Agents; Anticonvulsants; Avoidance Learning; Brain; Disease Models, Animal;

2017
A rapid and simple HPLC-MS/MS method for the simultaneous quantification of valproic acid and its five metabolites in human plasma and application to study pharmacokinetic interaction in Chinese epilepsy patients.
    Journal of pharmaceutical and biomedical analysis, 2018, Feb-05, Volume: 149

    Topics: Adolescent; Adult; Anticonvulsants; Asian People; Chromatography, High Pressure Liquid; Drug Interac

2018
Influence of valproate on language functions in children with epilepsy.
    Epilepsy & behavior : E&B, 2018, Volume: 78

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Cognition; Dose-Response Relationship, Drug; D

2018
Vitamin D deficiency in children with epilepsy taking valproate and levetiracetam as monotherapy.
    Epilepsy research, 2018, Volume: 139

    Topics: Adolescent; Child; Cross-Sectional Studies; Epilepsy; Female; Humans; Levetiracetam; Male; Prevalenc

2018
Does Valproic Acid/Na Valproate Suppress Auditory Startle Reflex in Patients With Epilepsy?
    Clinical EEG and neuroscience, 2018, Volume: 49, Issue:6

    Topics: Acoustic Stimulation; Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Humans; Male; Middle Age

2018
Marked efficacy of combined three-drug therapy (Sodium Valproate, Topiramate and Stiripentol) in a patient with Dravet syndrome.
    Journal of clinical pharmacy and therapeutics, 2018, Volume: 43, Issue:4

    Topics: Anticonvulsants; Child, Preschool; Dioxolanes; Drug Therapy, Combination; Epilepsies, Myoclonic; Epi

2018
Evaluation of sex hormones and sperm parameters in male epileptic patients.
    Acta neurologica Scandinavica, 2018, Volume: 137, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Gonadal Steroid Hormones; Gonadotropins

2018
Population pharmacokinetics of lamotrigine co-administered with valproic acid in Chinese epileptic children using nonlinear mixed effects modeling.
    European journal of clinical pharmacology, 2018, Volume: 74, Issue:5

    Topics: Adolescent; Anticonvulsants; Asian People; Child; Child, Preschool; Drug Therapy, Combination; Epile

2018
Subtherapeutic valproic acid plasma concentrations under concomitant dipyrone therapy in an epilepsy patient-a case report.
    European journal of clinical pharmacology, 2018, Volume: 74, Issue:5

    Topics: Aged; Analgesics; Anticonvulsants; Dipyrone; Epilepsy; Humans; Male; Valproic Acid

2018
Women with epilepsy in childbearing age: Pregnancy-related knowledge, information sources, and antiepileptic drugs.
    Epilepsy & behavior : E&B, 2018, Volume: 80

    Topics: Adolescent; Adult; Anticonvulsants; Counseling; Croatia; Epilepsy; Female; Health Knowledge, Attitud

2018
Micronization potentiates curcumin's anti-seizure effect and brings an important advance in epilepsy treatment.
    Scientific reports, 2018, 02-08, Volume: 8, Issue:1

    Topics: Animals; Anticonvulsants; Biological Availability; Curcumin; Disease Models, Animal; Drug Compoundin

2018
Utilization of Antiepileptic Medicines in Swedish Children and Adolescents with Different Diagnoses.
    Basic & clinical pharmacology & toxicology, 2018, Volume: 123, Issue:1

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Prescriptions; Drug Utilization; Epilepsy

2018
Safety of antiepileptic drugs in children and young people: A prospective cohort study.
    Seizure, 2018, Volume: 56

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Chi-Square Distribution; Child; Child, Preschool; Cohort

2018
Vitamin D Deficiency in Ambulant Children on Carbamazepine or Sodium Valproate Monotherapy.
    Indian pediatrics, 2018, Apr-15, Volume: 55, Issue:4

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Case-Control Studies; Child; Child, Preschool; Cross-Sec

2018
Pharmacokinetic variability of valproate during pregnancy - Implications for the use of therapeutic drug monitoring.
    Epilepsy research, 2018, Volume: 141

    Topics: Adult; Anticonvulsants; Dose-Response Relationship, Drug; Drug Monitoring; Epilepsy; Female; Humans;

2018
Antiepileptic Drugs in Pregnancy-Quick Decisions With Long-term Consequences.
    JAMA neurology, 2018, 06-01, Volume: 75, Issue:6

    Topics: Anticonvulsants; Child; Epilepsy; Female; Humans; Language; Mathematics; Pregnancy; Pregnancy Compli

2018
Outcomes of pregnancies in women taking antiepileptic drugs for non-epilepsy indications.
    Seizure, 2018, Volume: 56

    Topics: Abnormalities, Drug-Induced; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Outcome Ass

2018
Valproate-induced Hyperammonemic Encephalopathy Presenting as Catatonia.
    The neurologist, 2018, Volume: 23, Issue:2

    Topics: Adult; Anticonvulsants; Brain Diseases; Catatonia; Epilepsy; Female; Humans; Hyperammonemia; Valproi

2018
Effect of antiepileptic drug comedication on lamotrigine concentrations.
    Croatian medical journal, 2018, Feb-28, Volume: 59, Issue:1

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Inte

2018
A Cross-Sectional Study to Assess the Modulation of Wnt Inhibitors following Anti-Epileptic Drug Therapy and their Correlation with Vitamin D and Receptor Activator of Nuclear Factor κ B Ligand in Indian Women with Epilepsy.
    Basic & clinical pharmacology & toxicology, 2018, Volume: 123, Issue:3

    Topics: Adaptor Proteins, Signal Transducing; Adult; Anticonvulsants; Bone Morphogenetic Proteins; Carbamaze

2018
Declining trend in valproate use in Finland among females of childbearing age in 2012-2016 - a nationwide registry-based outpatient study.
    European journal of neurology, 2018, Volume: 25, Issue:6

    Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Finland; Humans; Male; Outpatients; Registries

2018
Observational multicentre study into the use of antiepileptic drugs in Spanish neurology consultations.
    Neurologia, 2020, Volume: 35, Issue:2

    Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Female; Humans; Lamotrigine; Levetirace

2020
A population pharmacokinetic model taking into account protein binding for the sustained-release granule formulation of valproic acid in children with epilepsy.
    European journal of clinical pharmacology, 2018, Volume: 74, Issue:6

    Topics: Adolescent; Anticonvulsants; Body Weight; Child; Child, Preschool; Delayed-Action Preparations; Epil

2018
Reader response: Expression of Concern: Does compensatory hyperparathyroidism predispose to ischemic stroke? Decreased bone mass and increased bone turnover with valproate therapy in adults with epilepsy; An alternative to vitamin D supplementation to pre
    Neurology, 2018, Mar-27, Volume: 90, Issue:13

    Topics: Adult; Bone Density; Bone Remodeling; Brain Ischemia; Dietary Supplements; Epilepsy; Humans; Hyperpa

2018
[A nationwide multi-center questionnaire survey on the management and treatment of post-stroke seizure and epilepsy in Japan].
    Rinsho shinkeigaku = Clinical neurology, 2018, Apr-25, Volume: 58, Issue:4

    Topics: Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Japan; Levetiracetam; Male; Piracetam; Sei

2018
Carnitine Deficiency in Chinese Children with Epilepsy on Valproate Monotherapy.
    Indian pediatrics, 2018, 03-15, Volume: 55, Issue:3

    Topics: Anticonvulsants; Beijing; Carnitine; Case-Control Studies; Child, Preschool; Deficiency Diseases; Ep

2018
Weighing the risks of valproate in women who could become pregnant.
    BMJ (Clinical research ed.), 2018, Apr-18, Volume: 361

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Contraindications, Drug; Developmental Disabilities; E

2018
Dangers of valproate in pregnancy.
    BMJ (Clinical research ed.), 2018, 04-18, Volume: 361

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complic

2018
Sodium valproate-induced Fanconi syndrome in two severely disabled patients receiving carnitine supplementation.
    Clinical and experimental nephrology, 2019, Volume: 23, Issue:1

    Topics: Adult; Anticonvulsants; Carnitine; Disabled Persons; Epilepsy; Fanconi Syndrome; Female; Humans; Int

2019
The effects of valproate and topiramate use on serum insulin, leptin, neuropeptide Y and ghrelin levels in epileptic children.
    Seizure, 2018, Volume: 58

    Topics: Adolescent; Anticonvulsants; Biomarkers; Blood Glucose; Body Mass Index; Child; Epilepsy; Fructose;

2018
Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry.
    The Lancet. Neurology, 2018, Volume: 17, Issue:6

    Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug

2018
Valproate and epilepsy: for women as well as men.
    Practical neurology, 2018, Volume: 18, Issue:3

    Topics: Anticonvulsants; Epilepsy; Female; Humans; Male; Sex Factors; Valproic Acid

2018
Carbamazepine Verses Valproic Acid as Monotherapy in Epileptic Patients.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2018, Volume: 28, Issue:5

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Chromatography, Liquid; Epilepsy; Female;

2018
ABCC2 rs2273697 is associated with valproic acid concentrations in patients with epilepsy on valproic acid monotherapy.
    Die Pharmazie, 2018, 05-01, Volume: 73, Issue:5

    Topics: Adult; Anticonvulsants; Asian People; Epilepsy; Female; Genotype; Humans; Male; Multidrug Resistance

2018
Prevalence of valproate syndrome in Europe from 2005 to 2014: A registry based multi-centre study.
    European journal of medical genetics, 2018, Volume: 61, Issue:9

    Topics: Adult; Anticonvulsants; Cognitive Dysfunction; Congenital Abnormalities; Epilepsy; Europe; Female; H

2018
Evaluation ofserum free carnitine/acylcarnitine levels and left ventricular systolic functions in children with idiopathic epilepsy receiving valproic acid.
    Clinical neurology and neurosurgery, 2018, Volume: 170

    Topics: Adolescent; Anticonvulsants; Biomarkers; Carnitine; Child; Child, Preschool; Electrocardiography; Ep

2018
The preconception care experiences of women with epilepsy on sodium valproate.
    Seizure, 2018, Volume: 59

    Topics: Adolescent; Adult; Anticonvulsants; Decision Making; Drug Substitution; Epilepsy; Female; Health Beh

2018
Interaction between ABCG2 421C>A polymorphism and valproate in their effects on steady-state disposition of lamotrigine in adults with epilepsy.
    British journal of clinical pharmacology, 2018, Volume: 84, Issue:9

    Topics: Adolescent; Adult; Aged; Alleles; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; AT

2018
Risk Factors for Valproic Acid-induced Hyperammonaemia in Chinese Paediatric Patients with Epilepsy.
    Basic & clinical pharmacology & toxicology, 2018, Volume: 123, Issue:5

    Topics: Age Factors; Ammonia; Anticonvulsants; Aspartate Aminotransferases; Chemical and Drug Induced Liver

2018
Guidance is needed on valproate in pregnancy for those without capacity.
    BMJ (Clinical research ed.), 2018, 05-29, Volume: 361

    Topics: Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Valproic Acid

2018
Prescribing in pregnancy shows the weaknesses in pharmacovigilance.
    BMJ (Clinical research ed.), 2018, May-29, Volume: 361

    Topics: Anticonvulsants; Epilepsy; Female; Humans; Pharmacovigilance; Pregnancy; Pregnancy Complications; Va

2018
[Establish and use of an epilepsy model in larval zebrafish].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2016, Volume: 51, Issue:4

    Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Epilepsy; Larva; Nerve Tissue Proteins; Pen

2016
Childhood Visual Hallucinations: A Case Report of Idiopathic Occipital Epilepsy.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2018, Volume: 57, Issue:6

    Topics: Child; Electroencephalography; Epilepsy; Female; Hallucinations; Humans; Occipital Lobe; Psychiatric

2018
Teaching NeuroImages: Dyke-Davidoff-Masson syndrome.
    Neurology, 2018, 06-05, Volume: 90, Issue:23

    Topics: Anticonvulsants; Cerebral Cortex; Epilepsy; Humans; Magnetic Resonance Imaging; Male; Middle Aged; V

2018
Effect of valproic acid on perampanel pharmacokinetics in patients with epilepsy.
    Epilepsia, 2018, Volume: 59, Issue:7

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Cytochrome P-450 Enzyme Inducers; Cytochrome P-450

2018
Obstetric outcomes and effects on babies born to women treated for epilepsy during pregnancy in a resource limited setting: a comparative cohort study.
    BMC pregnancy and childbirth, 2018, Jun-14, Volume: 18, Issue:1

    Topics: Abortion, Spontaneous; Adolescent; Adult; Anticonvulsants; Body Height; Body Weight; Carbamazepine;

2018
Biochemical derangements related to metabolic syndrome in epileptic patients on treatment with valproic acid.
    Seizure, 2018, Volume: 60

    Topics: Adolescent; Adult; Anticonvulsants; Biomarkers; Body Mass Index; Cholesterol; Cross-Sectional Studie

2018
Reducing valproate use in women with epilepsy.
    The Lancet. Neurology, 2018, Volume: 17, Issue:7

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Drug Utilization; Epilepsy; Female;

2018
[Prescribing valproate to girls and women of childbearing age in Germany : Analysis of trends based on claims data].
    Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz, 2018, Volume: 61, Issue:8

    Topics: Adult; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Drug Prescriptions; Drug Utilization; Ep

2018
Nonlesional late-onset epilepsy: Semiology, EEG, cerebrospinal fluid, and seizure outcome characteristics.
    Epilepsy & behavior : E&B, 2019, Volume: 91

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Electroencephalography; Epilepsy; Femal

2019
Memory dysfunction in school-aged children exposed prenatally to antiepileptic drugs.
    Neuropsychology, 2018, Volume: 32, Issue:7

    Topics: Adult; Anticonvulsants; Carbamazepine; Child; Dose-Response Relationship, Drug; Epilepsy; Female; Hu

2018
Population pharmacokinetics of valproic acid in epileptic children: Effects of clinical and genetic factors.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2018, Sep-15, Volume: 122

    Topics: Adolescent; Anticonvulsants; Asian People; ATP-Binding Cassette Transporters; Child; Child, Preschoo

2018
Polymorphisms of peroxisome proliferator-activated receptor γ (PPARγ) and cluster of differentiation 36 (CD36) associated with valproate-induced obesity in epileptic patients.
    Psychopharmacology, 2018, Volume: 235, Issue:9

    Topics: Adolescent; Adult; Alleles; Anticonvulsants; Asian People; Body Mass Index; Body Weight; CD36 Antige

2018
Valproate free serum concentrations: More complex than simple formulas.
    Seizure, 2018, Volume: 60

    Topics: Anticonvulsants; Epilepsy; Humans; Prospective Studies; Valproic Acid

2018
Renal dysfunctions/injury in adult epilepsy patients treated with carbamazepine or valproate.
    Expert review of clinical pharmacology, 2018, Volume: 11, Issue:8

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Creatinine; Cross-Sectional Studies; Epilepsy; Fe

2018
Levetiracetam and lamotrigine effects as mono- and polytherapy on bone mineral density in epileptic patients.
    Arquivos de neuro-psiquiatria, 2018, Volume: 76, Issue:7

    Topics: Adolescent; Adult; Amino Acids; Anticonvulsants; Biomarkers; Bone Density; Bone Remodeling; Case-Con

2018
Valproate-associated foetal malformations-Rates of occurrence, risks in attempted avoidance.
    Acta neurologica Scandinavica, 2019, Volume: 139, Issue:1

    Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Australia; Epilepsy; Female; Humans; Pregnancy;

2019
Evaluation of ghrelin, nesfatin-1 and irisin levels of serum and brain after acute or chronic pentylenetetrazole administrations in rats using sodium valproate.
    Neurological research, 2018, Volume: 40, Issue:11

    Topics: Animals; Anticonvulsants; Biomarkers; Brain; Calcium-Binding Proteins; Disease Models, Animal; DNA-B

2018
New regulations to cut valproate-exposed pregnancies.
    Lancet (London, England), 2018, 08-11, Volume: 392, Issue:10146

    Topics: Anticonvulsants; Epilepsy; Female; Government Regulation; Humans; Pregnancy; Pregnancy Complications

2018
Diacylglycerol kinase (DGKA) regulates the effect of the epilepsy and bipolar disorder treatment valproic acid in
    Disease models & mechanisms, 2018, 08-21, Volume: 11, Issue:9

    Topics: Amino Acid Sequence; Anticonvulsants; Bipolar Disorder; Diacylglycerol Kinase; Dictyostelium; Diglyc

2018
Valproate, women, and exceptional circumstances.
    BMJ (Clinical research ed.), 2018, Aug-28, Volume: 362

    Topics: Anticonvulsants; Drug Prescriptions; Drug Utilization; Epilepsy; Female; Humans; Pregnancy; Teratoge

2018
A Population Pharmacokinetic-Pharmacogenetic Model of Lamotrigine in Chinese Children With Epilepsy.
    Therapeutic drug monitoring, 2018, Volume: 40, Issue:6

    Topics: Anticonvulsants; Asian People; ATP-Binding Cassette Transporters; Child; Drug Interactions; Epilepsy

2018
Variants p.Q1236H and p.E1143G in mitochondrial DNA polymerase gamma POLG1 are not associated with increased risk for valproate-induced hepatotoxicity or pancreatic toxicity: A retrospective cohort study of patients with epilepsy.
    Epilepsia, 2018, Volume: 59, Issue:11

    Topics: Adolescent; Adult; Alanine Transaminase; Anticonvulsants; Aspartate Aminotransferases; Chemical and

2018
Sodium valproate: who knew what and when? Cumulative meta-analysis gives extra insights.
    BMJ evidence-based medicine, 2019, Volume: 24, Issue:4

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Meta-Analysis as Topic; Preg

2019
Sodium valproate correcting hypernatremia of diabetes insipidus-a fortunate incident.
    QJM : monthly journal of the Association of Physicians, 2018, Nov-01, Volume: 111, Issue:11

    Topics: Adult; Diabetes Insipidus, Neurogenic; Epilepsy; Humans; Hypernatremia; Male; Valproic Acid

2018
Severe hyperammonaemic encephalopathy resulting from the overlap between hepatic and valproate encephalopathy.
    Postgraduate medical journal, 2018, Volume: 94, Issue:1117

    Topics: Alcoholism; Brain Diseases; Epilepsy; Humans; Hyperammonemia; Hypertension, Portal; Male; Middle Age

2018
Vitamin D status in children with epilepsy treated with levetiracetam monotherapy.
    Epilepsy research, 2018, Volume: 148

    Topics: Child; Epilepsy; Humans; Levetiracetam; Piracetam; Valproic Acid; Vitamin D; Vitamin D Deficiency

2018
Catalase C-262T Polymorphism Is a Risk Factor for Valproic Acid-Induced Abnormal Liver Function in Chinese Patients With Epilepsy.
    Therapeutic drug monitoring, 2019, Volume: 41, Issue:1

    Topics: Adolescent; Anticonvulsants; Asian People; Catalase; Chemical and Drug Induced Liver Injury; Child;

2019
Long-Term Safety, Tolerability, and Efficacy of Cannabidiol in Children with Refractory Epilepsy: Results from an Expanded Access Program in the US.
    CNS drugs, 2019, Volume: 33, Issue:1

    Topics: Adolescent; Anticonvulsants; Cannabidiol; Child; Child, Preschool; Drug Therapy, Combination; Epilep

2019
Valproate-Induced Polycystic Ovary Syndrome in a Girl with Epilepsy: A Case Study.
    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 2018, Volume: 85, Issue:5

    Topics: Adolescent; Biomarkers; Epilepsy; Female; Humans; Luteinizing Hormone; Magnetic Resonance Imaging; P

2018
[Valproate sodium (and its derivatives) and risk of teratogenicity].
    La Revue du praticien, 2017, Volume: 67, Issue:1

    Topics: Anticonvulsants; Epilepsy; Humans; Valproic Acid

2017
Perinatal outcome and healthcare resource utilization in the first year of life after antiepileptic exposure during pregnancy.
    Epilepsy & behavior : E&B, 2019, Volume: 92

    Topics: Adult; Anticonvulsants; Databases, Factual; Epilepsy; Female; Health Resources; Humans; Infant; Infa

2019
Trends in valproate use in patients in Germany between 2009 and 2017.
    Epilepsy & behavior : E&B, 2019, Volume: 92

    Topics: Adolescent; Adult; Anticonvulsants; Cross-Sectional Studies; Drug Prescriptions; Epilepsy; Female; G

2019
Adverse drug reactions associated with six commonly used antiepileptic drugs in southern China from 2003 to 2015.
    BMC pharmacology & toxicology, 2019, Jan-14, Volume: 20, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Child; Child, Preschool; China; Epileps

2019
The influence of concomitant antiepileptic drugs on lamotrigine serum concentrations in Northwest Chinese Han population with epilepsy.
    PloS one, 2019, Volume: 14, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Asian People; Carbamazepine; Child; Child, Preschool; China; Dru

2019
Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Risk for Attention-Deficit/Hyperactivity Disorder in Offspring.
    JAMA network open, 2019, 01-04, Volume: 2, Issue:1

    Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Child; Cohort Studies; Denmark; Epil

2019
Fetal antiepileptic drug exposure and learning and memory functioning at 6 years of age: The NEAD prospective observational study.
    Epilepsy & behavior : E&B, 2019, Volume: 92

    Topics: Adult; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Humans; Lamotrigine; Learning; Memor

2019
Valproic acid-induced nocturnal enuresis in pediatric patients.
    Nigerian journal of clinical practice, 2019, Volume: 22, Issue:1

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Headache; Humans; Incidence;

2019
Energy Drink-Induced Breakthrough Seizure in a Patient on Valproic Acid-Considering Herbal Safety in Epilepsy.
    Journal of pharmacy practice, 2019, Volume: 32, Issue:5

    Topics: Adolescent; Anticonvulsants; Energy Drinks; Epilepsy; Herb-Drug Interactions; Humans; Male; Seizures

2019
Preliminary evidence about irritability in patients with epilepsy treated by perampanel as first add-on therapy compared to levetiracetam and valproic acid.
    CNS neuroscience & therapeutics, 2019, Volume: 25, Issue:5

    Topics: Adult; Anticonvulsants; Anxiety; Drug Therapy, Combination; Epilepsy; Female; Humans; Irritable Mood

2019
Lamotrigine drug interactions in combination therapy and the influence of therapeutic drug monitoring on clinical outcomes in paediatric patients.
    Basic & clinical pharmacology & toxicology, 2019, Volume: 125, Issue:1

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Czech Republic; Dose-Response R

2019
SCN1A and SCN2A polymorphisms are associated with response to valproic acid in Chinese epilepsy patients.
    European journal of clinical pharmacology, 2019, Volume: 75, Issue:5

    Topics: Adolescent; Adult; Anticonvulsants; Asian People; Child; Child, Preschool; Epilepsy; Female; Genetic

2019
AMPA receptor antagonist perampanel affects glioblastoma cell growth and glutamate release in vitro.
    PloS one, 2019, Volume: 14, Issue:2

    Topics: Anticonvulsants; Antineoplastic Agents; Apoptosis; Brain; Brain Neoplasms; Cell Line, Tumor; Cell Pr

2019
Valproate is contraindicated in pregnancy.
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2019, 02-12, Volume: 139, Issue:3

    Topics: Anticonvulsants; Contraindications, Drug; Epilepsy; Female; Humans; Neurodevelopmental Disorders; Pr

2019
The clinical characteristics and related factors of tremor in patients with epilepsy.
    Seizure, 2019, Volume: 66

    Topics: Activities of Daily Living; Adult; Anticonvulsants; Case-Control Studies; Drug-Related Side Effects

2019
Serum carnitine levels of children with epilepsy: Related factors including valproate.
    Brain & development, 2019, Volume: 41, Issue:6

    Topics: Adolescent; Body Mass Index; Carnitine; Child; Child, Preschool; Cognitive Dysfunction; Epilepsy; Fe

2019
Level of empowerment and decision-making style of women with epilepsy in childbirth age.
    Epilepsy & behavior : E&B, 2019, Volume: 93

    Topics: Adolescent; Adult; Anticonvulsants; Decision Making; Empowerment; Epilepsy; Female; Humans; Middle A

2019
Developmental outcomes at age four following maternal antiepileptic drug use.
    Epilepsy & behavior : E&B, 2019, Volume: 93

    Topics: Adult; Anticonvulsants; Carbamazepine; Child Development; Child, Preschool; Cohort Studies; Epilepsy

2019
Effects of Sodium Valproate, Levetiracetam and Phenytoin Therapy on Evoked Potentials in Children with Epilepsy.
    Indian journal of pediatrics, 2019, Volume: 86, Issue:9

    Topics: Adolescent; Child; Child, Preschool; Cross-Sectional Studies; Epilepsy; Evoked Potentials; Humans; L

2019
Valproate under threat.
    The Australian and New Zealand journal of psychiatry, 2019, Volume: 53, Issue:9

    Topics: Anticonvulsants; Epilepsy; Europe; Female; Humans; Valproic Acid

2019
Adverse Drug Reactions of Anti-Epileptic Drugs in Children with Epilepsy: A Cross-Sectional Study.
    Current drug safety, 2019, Volume: 14, Issue:3

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Cross-Sectional Studies; Epilepsy; Female; Hum

2019
Effects of levetiracetam and valproic acid treatment on liver function tests, plasma free carnitine and lipid peroxidation in childhood epilepsies.
    Epilepsy research, 2019, Volume: 153

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Anticonvulsants; Carnitine; Child; Deoxyguanosine; Epilepsy; Female; Hu

2019
Correlation of MCT1 and ABCC2 gene polymorphisms with valproic acid resistance in patients with epilepsy on valproic acid monotherapy.
    Drug metabolism and pharmacokinetics, 2019, Volume: 34, Issue:3

    Topics: Adult; Anticonvulsants; Drug Resistance; Epilepsy; Female; Genotype; Humans; Male; Monocarboxylic Ac

2019
Changes in Serum Valproate and Levetiracetam Levels Related to Sex Steroids in Adolescent Girls.
    Pediatric neurology, 2019, Volume: 96

    Topics: Adolescent; Anticonvulsants; Child; Epilepsy; Estradiol; Female; Humans; Levetiracetam; Menstrual Cy

2019
Valproate and the Pregnancy Prevention Programme.
    The British journal of general practice : the journal of the Royal College of General Practitioners, 2019, Volume: 69, Issue:682

    Topics: Epilepsy; Female; Humans; Pregnancy; Pregnancy Complications; Valproic Acid

2019
Valproic acid concentrations in nursing mothers, mature milk, and breastfed infants in monotherapy and combination therapy.
    Epilepsy & behavior : E&B, 2019, Volume: 95

    Topics: Adult; Animals; Anticonvulsants; Breast Feeding; Drug Therapy, Combination; Epilepsy; Female; Humans

2019
Etiology of neonatal seizures and maintenance therapy use: a 10-year retrospective study at Toulouse Children's hospital.
    BMC pediatrics, 2019, 04-29, Volume: 19, Issue:1

    Topics: Anticonvulsants; Carbamazepine; Clonazepam; Cohort Studies; Databases, Factual; Dose-Response Relati

2019
The effect of co-administration of pentylenetetrazole with pilocarpine: New modified PTZ models of kindling and seizure.
    Pharmacology, biochemistry, and behavior, 2019, Volume: 182

    Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Drug Resistance; Epilepsy; Kindling,

2019
Potential biomarker of fibroblast growth factor 21 in valproic acid-treated livers.
    BioFactors (Oxford, England), 2019, Volume: 45, Issue:5

    Topics: Adult; Animals; Anticonvulsants; Biomarkers; Case-Control Studies; Chemical and Drug Induced Liver I

2019
Attenuation of retinal nerve fibre layer in people with epilepsy receiving valproate.
    Epilepsy research, 2019, Volume: 154

    Topics: Adolescent; Adult; Case-Control Studies; Epilepsy; Female; Humans; Male; Nerve Fibers; Retinal Neuro

2019
Lipidomic characteristics and clinical findings of epileptic patients treated with valproic acid.
    Journal of cellular and molecular medicine, 2019, Volume: 23, Issue:9

    Topics: Anticonvulsants; Biomarkers; Dyslipidemias; Epilepsy; Female; Humans; Lipid Metabolism; Lipidomics;

2019
Behavioral problems in children of mothers with epilepsy prenatally exposed to valproate, carbamazepine, lamotrigine, or levetiracetam monotherapy.
    Epilepsia, 2019, Volume: 60, Issue:6

    Topics: Adult; Anticonvulsants; Carbamazepine; Child; Child Behavior Disorders; Epilepsy; Female; Humans; La

2019
Management and attitudes toward patients with epilepsy in general practice: How far have we come in three decades?
    Epilepsy & behavior : E&B, 2019, Volume: 97

    Topics: Adult; Anticonvulsants; Attitude of Health Personnel; Australia; Carbamazepine; Clinical Competence;

2019
Valproic acid potently inhibits interictal-like epileptiform activity in prefrontal cortex pyramidal neurons.
    Neuroscience letters, 2019, 08-24, Volume: 708

    Topics: Animals; Anticonvulsants; Epilepsy; Excitatory Postsynaptic Potentials; Prefrontal Cortex; Pyramidal

2019
Valproate and female patients: Prescribing attitudes of Italian epileptologists.
    Epilepsy & behavior : E&B, 2019, Volume: 97

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Attitude of Health Personnel; Child; Epilepsy; Female; Hum

2019
Vitamin D supplementation and bone markers in ambulatory children on long-term valproic acid therapy. A prospective interventional study.
    Epilepsy & behavior : E&B, 2019, Volume: 97

    Topics: Adolescent; Alkaline Phosphatase; Anticonvulsants; Biomarkers; Bone and Bones; Bone Remodeling; Chil

2019
Why do some women with epilepsy use valproic acid despite current guidelines? A single-center cohort study.
    Epilepsy & behavior : E&B, 2019, Volume: 98, Issue:Pt A

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Cohort Studies; Epilepsy; Female; H

2019
Pharmacist impact on adherence of valproic acid therapy in pediatric patients with epilepsy using active education techniques.
    Epilepsy & behavior : E&B, 2019, Volume: 98, Issue:Pt A

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; China; Epilepsy; Female; Humans; Infant; Male;

2019
Self-reported attitudes about medication in Lebanese people with epilepsy.
    Epilepsy & behavior : E&B, 2019, Volume: 98, Issue:Pt A

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Attitude to Health; Carbamazepine; Cros

2019
Valproate utilisation trends among girls and women from 2013 to 2018.
    Seizure, 2019, Volume: 70

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Utilization; Epilepsy; Female; Hum

2019
Use of antiepileptic drugs in women of fertile age.
    Danish medical journal, 2019, Volume: 66, Issue:8

    Topics: Adolescent; Adult; Anticonvulsants; Denmark; Epilepsy; Female; Gabapentin; Humans; Lamotrigine; Leve

2019
ARX-associated infantile epileptic-dyskinetic encephalopathy with responsiveness to valproate for controlling seizures and reduced activity of muscle mitochondrial complex IV.
    Brain & development, 2019, Volume: 41, Issue:10

    Topics: Adolescent; Adult; Asian People; China; Cytochrome-c Oxidase Deficiency; Dystonic Disorders; Epileps

2019
Fragility fractures and reversible osteopaenia due to chronic hyponatraemia in an adolescent male.
    BMJ case reports, 2019, Jul-27, Volume: 12, Issue:7

    Topics: Absorptiometry, Photon; Adolescent; Anticonvulsants; Bone Density; Bone Diseases, Metabolic; Epileps

2019
A 16q22.2-q23.1 deletion identified in a male infant with West syndrome.
    Brain & development, 2019, Volume: 41, Issue:10

    Topics: Anticonvulsants; Chromosomes, Human, Pair 16; Epilepsy; Humans; Infant; Intellectual Disability; Lam

2019
Effects of Histone Deacetylase Inhibitors on the Development of Epilepsy and Psychiatric Comorbidity in WAG/Rij Rats.
    Molecular neurobiology, 2020, Volume: 57, Issue:1

    Topics: Acetylation; Action Potentials; Animals; Avoidance Learning; Behavior, Animal; Butyric Acid; Comorbi

2020
Risk factors for hyperammonemia in pediatric patients with epilepsy.
    Epilepsia, 2013, Volume: 54, Issue:6

    Topics: Acetazolamide; Adolescent; Age Factors; Anticonvulsants; Child; Child, Preschool; Dose-Response Rela

2013
Associations between particular types of fetal malformation and antiepileptic drug exposure in utero.
    Acta neurologica Scandinavica, 2013, Volume: 128, Issue:4

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Australia; Epilepsy; Female; Fetal Diseases; Fructose;

2013
Unusual drug reaction between valproate sodium and meropenem.
    International journal of clinical pharmacy, 2013, Volume: 35, Issue:3

    Topics: Aged; Anti-Bacterial Agents; Anticonvulsants; Bacterial Infections; beta-Lactams; Drug Interactions;

2013
[Patent rickets disclosed by loss of convulsion control in a boy with cerebral palsy].
    The Pan African medical journal, 2013, Volume: 14

    Topics: Anticonvulsants; Calcium; Carbamazepine; Cerebral Palsy; Child, Preschool; Diazepam; Epilepsy; Human

2013
Quantitative determination of valproic acid in postmortem blood samples--evidence of strong matrix dependency and instability.
    International journal of legal medicine, 2013, Volume: 127, Issue:6

    Topics: Autopsy; Blood Preservation; Blood Specimen Collection; Death, Sudden; Dose-Response Relationship, D

2013
[Carnitine deficiency with valproate sodium therapy--the difference by normal diet and enteral nutrition].
    No to hattatsu = Brain and development, 2013, Volume: 45, Issue:1

    Topics: Adolescent; Adult; Carnitine; Child; Child, Preschool; Dietary Supplements; Enteral Nutrition; Epile

2013
EEG improvements with antiepileptic drug treatment can show a high correlation with behavioral recovery in children with ADHD.
    Epilepsy & behavior : E&B, 2013, Volume: 27, Issue:3

    Topics: Adolescent; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Brain Waves; Child; Elec

2013
Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism.
    JAMA, 2013, Apr-24, Volume: 309, Issue:16

    Topics: Adolescent; Adult; Anticonvulsants; Autistic Disorder; Child; Child Development Disorders, Pervasive

2013
Risks of in utero exposure to valproate.
    JAMA, 2013, Apr-24, Volume: 309, Issue:16

    Topics: Anticonvulsants; Autistic Disorder; Child Development Disorders, Pervasive; Epilepsy; Female; Humans

2013
Sodium valproate use is associated with reduced parietal lobe thickness and brain volume.
    Neurology, 2013, May-14, Volume: 80, Issue:20

    Topics: Adult; Brain; Cohort Studies; Epilepsy; Humans; Male; Middle Aged; Organ Size; Parietal Lobe; Valpro

2013
Valproate in pregnancy linked to autism in children.
    BMJ (Clinical research ed.), 2013, Apr-24, Volume: 346

    Topics: Anticonvulsants; Autistic Disorder; Denmark; Epilepsy; Female; Humans; Incidence; Infant, Newborn; P

2013
Report: Fatal toxic epidermal necrolysis induced by sodium valproate.
    Pakistan journal of pharmaceutical sciences, 2013, Volume: 26, Issue:3

    Topics: Adult; Epilepsy; Fatal Outcome; Humans; Male; Stevens-Johnson Syndrome; Valproic Acid

2013
Sodium valproate induced tremor in a patient with epilepsy and Down's syndrome.
    Current drug safety, 2013, Volume: 8, Issue:1

    Topics: Adolescent; Anticonvulsants; Down Syndrome; Epilepsy; GABA Agents; Humans; Male; Tremor; Valproic Ac

2013
Valproate and lamotrigine in pediatric patients with refractory epilepsy: after the first year.
    Pediatric neurology, 2013, Volume: 48, Issue:6

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Female; H

2013
Asymmetric drug-induced tremor: rare feature of a common event.
    Pediatric neurology, 2013, Volume: 48, Issue:6

    Topics: Anticonvulsants; Child; Epilepsy; Female; Humans; Tremor; Valproic Acid

2013
Chronic valproic acid intoxication.
    Pediatric emergency care, 2013, Volume: 29, Issue:6

    Topics: Anticonvulsants; Cerebral Palsy; Chemistry, Pharmaceutical; Child; Chronic Disease; Developmental Di

2013
The effect of uridine diphosphate glucuronosyltransferase (UGT)1A6 genetic polymorphism on valproic acid pharmacokinetics in Indian patients with epilepsy: a pharmacogenetic approach.
    Molecular diagnosis & therapy, 2013, Volume: 17, Issue:5

    Topics: Adolescent; Adult; Anticonvulsants; Child; Epilepsy; Female; Genetic Variation; Genotype; Glucuronos

2013
The association between BsmI polymorphism and risk factors for atherosclerosis in patients with epilepsy taking valproate.
    Seizure, 2013, Volume: 22, Issue:9

    Topics: Adult; Anticonvulsants; Atherosclerosis; Cholesterol; Cross-Sectional Studies; Epilepsy; Female; Hum

2013
Epilepsy and brain injury: a case report of a dramatic neuropsychiatric vicious circle.
    Brain injury, 2013, Volume: 27, Issue:7-8

    Topics: Accidents, Traffic; Aggression; Amines; Anterior Temporal Lobectomy; Anticonvulsants; Brain Injuries

2013
Atherogenic consequence of antiepileptic drugs: a study of intima-media thickness.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2014, Volume: 35, Issue:2

    Topics: Adult; Age Factors; Anticonvulsants; Atherosclerosis; Carotid Arteries; Carotid Intima-Media Thickne

2014
Valproic acid induced hyperammonaemic encephalopathy.
    JPMA. The Journal of the Pakistan Medical Association, 2013, Volume: 63, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Brain Diseases; Child; Child, Preschool; Cohort Studies; Epileps

2013
Dose dependence of fetal malformations associated with valproate.
    Neurology, 2013, Sep-10, Volume: 81, Issue:11

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Austria; Dose-Response Relationship, Drug; Epilepsy; F

2013
Initial anticonvulsant monotherapy in routine care of children and adolescents: levetiracetam fails more frequently than valproate and oxcarbazepine due to a lack of effectiveness.
    European journal of pediatrics, 2014, Volume: 173, Issue:1

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Infan

2014
The effects of topiramate and valproate therapy on insulin, c-peptide, leptin, neuropeptide Y, adiponectin, visfatin, and resistin levels in children with epilepsy.
    Seizure, 2013, Volume: 22, Issue:10

    Topics: Adiponectin; Anticonvulsants; Body Mass Index; Body Weight; C-Peptide; Child; Epilepsy; Female; Fruc

2013
Effects of antiepileptic drugs on reproductive endocrine function, sexual function and sperm parameters in Chinese Han men with epilepsy.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2013, Volume: 20, Issue:11

    Topics: Adolescent; Adult; Anticonvulsants; Asian People; Epilepsy; Erectile Dysfunction; Follicle Stimulati

2013
Ventricular ectopic beats in a child receiving carbamazepine.
    Indian pediatrics, 2013, Jun-08, Volume: 50, Issue:6

    Topics: Anticonvulsants; Carbamazepine; Child; Electrocardiography; Epilepsy; Humans; Male; Syncope; Valproi

2013
[Characteristics of women with epilepsy who developed polycystic ovary syndrome owing to the therapy with valproate sodium].
    No to hattatsu = Brain and development, 2013, Volume: 45, Issue:4

    Topics: Adolescent; Adult; Androstenedione; Epilepsy; Female; Humans; Polycystic Ovary Syndrome; Practice Gu

2013
An unusual case of pleuropericardial neutrophilic effusion associated with valproate.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2015, Volume: 114, Issue:4

    Topics: Adult; Cough; Dyspnea; Echocardiography; Epilepsy; Female; Humans; Pericardial Effusion; Pericardioc

2015
Prenatal valproate exposure is associated with autism spectrum disorder and childhood autism.
    The Journal of pediatrics, 2013, Volume: 163, Issue:3

    Topics: Anticonvulsants; Autistic Disorder; Child Development Disorders, Pervasive; Epilepsy; Female; Humans

2013
Effect of UGT2B7 genetic variants on serum valproic acid concentration.
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2013, Volume: 38, Issue:8

    Topics: Adolescent; Adult; Anticonvulsants; Asian People; Base Sequence; Child; Child, Preschool; Epilepsy;

2013
Estimation and comparison of carbamazepine population pharmacokinetics using dried blood spot and plasma concentrations from people with epilepsy: the clinical implication.
    Journal of clinical pharmacology, 2014, Volume: 54, Issue:2

    Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Cross-Sectional Studies; Dried Blood Spot Testing; Drug

2014
Prenatal exposure to sodium valproate is associated with increased risk of childhood autism and autistic spectrum disorder.
    Evidence-based nursing, 2014, Volume: 17, Issue:3

    Topics: Anticonvulsants; Autistic Disorder; Child Development Disorders, Pervasive; Epilepsy; Female; Humans

2014
Valproate use during pregnancy was linked to autism spectrum disorder and childhood autism in offspring.
    Annals of internal medicine, 2013, Aug-20, Volume: 159, Issue:4

    Topics: Anticonvulsants; Autistic Disorder; Child Development Disorders, Pervasive; Epilepsy; Female; Humans

2013
A case of selective immunoglobulin A deficiency with anti-neutrophil cytoplasmic antibody-associated glomerulonephritis.
    International journal of rheumatic diseases, 2014, Volume: 17, Issue:3

    Topics: Antibodies, Antineutrophil Cytoplasmic; Antibodies, Antinuclear; Anticonvulsants; Epilepsy; Female;

2014
[Valproic acid during pregnancy lowers IQ in children].
    Versicherungsmedizin, 2013, Sep-01, Volume: 65, Issue:3

    Topics: Anticonvulsants; Epilepsy; Female; Humans; Intellectual Disability; Maternal-Fetal Exchange; Nervous

2013
Malformation in index pregnancy in women with epilepsy is not followed by recurrence in subsequent pregnancy.
    Epilepsia, 2013, Volume: 54, Issue:12

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; India; Pregna

2013
Locally applied valproate enhances survival in rats after neocortical treatment with tetanus toxin and cobalt chloride.
    BioMed research international, 2013, Volume: 2013

    Topics: Animals; Anticonvulsants; Behavior, Animal; Cobalt; Disease Models, Animal; Electroencephalography;

2013
Mystery case: a young boy with myoclonic jerks.
    Neurology, 2013, Oct-29, Volume: 81, Issue:18

    Topics: Adolescent; Electroencephalography; Epilepsy; Humans; Magnetic Resonance Imaging; Male; Myoclonus; P

2013
Impact of planning of pregnancy in women with epilepsy on seizure control during pregnancy and on maternal and neonatal outcomes.
    Seizure, 2014, Volume: 23, Issue:2

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Humans; Pregnancy

2014
Evaluation of anti-epileptic property of Marsilea quadrifolia Linn. in maximal electroshock and pentylenetetrazole-induced rat models of epilepsy.
    Brain injury, 2013, Volume: 27, Issue:13-14

    Topics: Animals; Convulsants; Disease Models, Animal; Electroshock; Epilepsy; Male; Marsileaceae; Pentylenet

2013
Glia and epilepsy: experimental investigation of antiepileptic drugs in an astroglia/microglia co-culture model of inflammation.
    Epilepsia, 2014, Volume: 55, Issue:1

    Topics: Amines; Animals; Anticonvulsants; Astrocytes; Blotting, Western; Carbamazepine; Cells, Cultured; Coc

2014
The impact of the use of antiepileptic drugs on the growth of children.
    BMC pediatrics, 2013, Dec-19, Volume: 13

    Topics: Adolescent; Anticonvulsants; Body Height; Bone Diseases, Developmental; Calcium; Carbamazepine; Cell

2013
Influence of uridine diphosphate glucuronosyltransferase 2B7 -161C>T polymorphism on the concentration of valproic acid in pediatric epilepsy patients.
    Therapeutic drug monitoring, 2014, Volume: 36, Issue:3

    Topics: Age Factors; Anticonvulsants; Body Weight; Child; Child, Preschool; Cytochrome P-450 CYP2C9; Drug Th

2014
Drug interaction between phenytoin and valproic acid in a child with refractory epilepsy: a case report.
    Journal of pharmacy practice, 2014, Volume: 27, Issue:2

    Topics: Anticonvulsants; Child; Drug Interactions; Epilepsy; Female; Humans; Phenytoin; Valproic Acid

2014
In utero exposure to levetiracetam vs valproate: development and language at 3 years of age.
    Neurology, 2014, Jan-21, Volume: 82, Issue:3

    Topics: Adult; Anticonvulsants; Child Development; Child, Preschool; Epilepsy; Female; Humans; Language Deve

2014
Reproductive endocrine health in pubertal females with epilepsy on antiepileptic drugs: time to screen?
    Neuropediatrics, 2014, Volume: 45, Issue:4

    Topics: Adiposity; Adolescent; Anticonvulsants; Cohort Studies; Cross-Sectional Studies; Drug Evaluation, Pr

2014
The effects of valproic acid and carbamazepine on strength-duration properties of peripheral nerve.
    Neurosciences (Riyadh, Saudi Arabia), 2014, Volume: 19, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Biophysics; Carbamazepine; Child; Electric Stimulation; Electroe

2014
[Season fluctuations of carbamazepine and valproate concentration in patients with epilepsy].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2013, Volume: 113, Issue:11

    Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Male; Middle Aged; Seasons; Valproi

2013
Malformation risks of antiepileptic drug monotherapies in pregnancy: updated results from the UK and Ireland Epilepsy and Pregnancy Registers.
    Journal of neurology, neurosurgery, and psychiatry, 2014, Volume: 85, Issue:9

    Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug

2014
Fetal growth restriction and birth defects with newer and older antiepileptic drugs during pregnancy.
    Journal of neurology, 2014, Volume: 261, Issue:3

    Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Birth Weight; Cohort Studies; Epilepsy; Female;

2014
[Valproate should be avoided in pregnancy].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2014, Jan-28, Volume: 134, Issue:2

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Prenatal Exposure

2014
[Valproic acid concentration in the blood serum of pregnant women and umbilical cord blood in relation to the condition of the newborn--case studies].
    Przeglad lekarski, 2013, Volume: 70, Issue:10

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Fetal Blood; Humans; Infant, Newborn; Pregnancy; Pregnancy

2013
Vitamin D levels in children and adolescents with antiepileptic drug treatment.
    Yonsei medical journal, 2014, Volume: 55, Issue:2

    Topics: Adolescent; Anticonvulsants; Bone Density; Bone Diseases, Metabolic; Carbamazepine; Child; Child, Pr

2014
Lacosamide serum concentrations in adult patients with epilepsy: the influence of gender, age, dose, and concomitant antiepileptic drugs.
    Therapeutic drug monitoring, 2014, Volume: 36, Issue:4

    Topics: Acetamides; Adult; Aged; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Inte

2014
[Epilepsy and transverse sternum fractures: sternum fractures in drug-induced osteopenia].
    Der Unfallchirurg, 2014, Volume: 117, Issue:12

    Topics: Adult; Anticonvulsants; Bone Diseases, Metabolic; Bone Plates; Epilepsy; Female; Fracture Fixation,

2014
Hemiconvulsion-hemiplegia-epilepsy syndrome: clinical course and neuroradiological features in a 20-month-old girl.
    BMJ case reports, 2014, Mar-10, Volume: 2014

    Topics: Anticonvulsants; Atrophy; Brain; Carbamazepine; Epilepsy; Female; Hemiplegia; Humans; Infant; Syndro

2014
Busulfan triggers epileptic seizures under levetiracetam and valproic acid therapy.
    Pediatric transplantation, 2014, Volume: 18, Issue:4

    Topics: Adolescent; Anticonvulsants; Busulfan; Drug Therapy, Combination; Epilepsy; Female; Hematopoietic St

2014
Characterization of a lamotrigine-resistant kindled model of epilepsy in mice: evaluation of drug resistance mechanisms.
    Basic & clinical pharmacology & toxicology, 2014, Volume: 115, Issue:5

    Topics: Animals; Anticonvulsants; Calcium Channels; Carbamazepine; Disease Models, Animal; Drug Resistance;

2014
Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism.
    Archives of disease in childhood. Education and practice edition, 2014, Volume: 99, Issue:5

    Topics: Anticonvulsants; Autistic Disorder; Child Development Disorders, Pervasive; Epilepsy; Female; Humans

2014
Sodium valproate-related hyperammonaemic encephalopathy.
    BMJ case reports, 2014, Apr-10, Volume: 2014

    Topics: Anticonvulsants; Epilepsy; Humans; Hyperammonemia; Male; Middle Aged; Neurotoxicity Syndromes; Valpr

2014
Effect of the entorhinal cortex on ictal discharges in low-Mg²⁺-induced epileptic hippocampal slice models.
    Neural plasticity, 2014, Volume: 2014

    Topics: Animals; Anticonvulsants; CA1 Region, Hippocampal; Data Interpretation, Statistical; Electroencephal

2014
Evaluation of thyroid hormones in children receiving carbamazepine or valproate: a prospective study.
    Journal of child neurology, 2015, Volume: 30, Issue:1

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Humans; Male; Prospective Studi

2015
First manic episode due to discontinuation of valproic acid in a patient with epilepsy.
    The Journal of neuropsychiatry and clinical neurosciences, 2014, Apr-01, Volume: 26, Issue:2

    Topics: Adult; Anticonvulsants; Bipolar Disorder; Drug Administration Schedule; Epilepsy; Female; Humans; Va

2014
Population pharmacokinetics of valproic acid in adult Chinese epileptic patients and its application in an individualized dosage regimen.
    Therapeutic drug monitoring, 2015, Volume: 37, Issue:1

    Topics: Adolescent; Adult; Aged; Algorithms; Anticonvulsants; Asian People; Chemistry, Pharmaceutical; Delay

2015
Hyperammonemia associated with valproic acid concentrations.
    BioMed research international, 2014, Volume: 2014

    Topics: Adolescent; Adult; Ammonia; Bipolar Disorder; Carnitine; Child; Dietary Supplements; Dose-Response R

2014
Chronic valproate or levetiracetam treatment does not influence cytokine levels in humans.
    Seizure, 2014, Volume: 23, Issue:8

    Topics: Anticonvulsants; Blood Chemical Analysis; Cytokines; Enzyme-Linked Immunosorbent Assay; Epilepsy; Fe

2014
4217C>A polymorphism in carbamoyl-phosphate synthase 1 gene may not associate with hyperammonemia development during valproic acid-based therapy.
    Epilepsy research, 2014, Volume: 108, Issue:6

    Topics: Alleles; Amino-Acid N-Acetyltransferase; Ammonia; Anticonvulsants; Asian People; Biomarkers, Pharmac

2014
Is sodium valproate, an HDAC inhibitor, associated with reduced risk of stroke and myocardial infarction? A nested case-control study.
    Pharmacoepidemiology and drug safety, 2014, Volume: 23, Issue:7

    Topics: Aged; Aged, 80 and over; Bias; Brain Ischemia; Case-Control Studies; Databases, Factual; Electronic

2014
Vascular function and risk factors in children with epilepsy: associations with sodium valproate and carbamazepine.
    Epilepsy research, 2014, Volume: 108, Issue:6

    Topics: Adolescent; Anticonvulsants; Aorta; Blood Glucose; Brachial Artery; Carbamazepine; Carotid Arteries;

2014
Reboxetine and its influence on the action of classical antiepileptic drugs in the mouse maximal electroshock model.
    Pharmacological reports : PR, 2014, Volume: 66, Issue:3

    Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Drug Interactions; Electrosh

2014
Valproate and folic acid in pregnancy: associations with autism.
    Developmental medicine and child neurology, 2014, Volume: 56, Issue:7

    Topics: Autistic Disorder; Epilepsy; Female; Folic Acid; Humans; Pregnancy; Prenatal Exposure Delayed Effect

2014
Effects of conventional anticonvulsant drugs on generalized tonic-clonic seizures in Noda epileptic rats.
    Epilepsy research, 2014, Volume: 108, Issue:7

    Topics: Animals; Anticonvulsants; Brain Waves; Disease Models, Animal; Dose-Response Relationship, Drug; Ele

2014
Does nephrotoxicity exist in pediatric epileptic patients on valproate or carbamazepine therapy?
    Journal of child neurology, 2015, Volume: 30, Issue:3

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Case-Control Studies; Child; Creatinine; Cystatin C; Epi

2015
[Effects of carbamazepine on plasma concentrations of valproic acid and its toxic metabolite in epileptic patients].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2014, Volume: 49, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epi

2014
The teratogenicity of the newer antiepileptic drugs - an update.
    Acta neurologica Scandinavica, 2014, Volume: 130, Issue:4

    Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Epilepsy; Female; Fetus; Fructose; Humans; Lamo

2014
Comparison of the metabolic syndrome risk in valproate-treated patients with epilepsy and the general population in Estonia.
    PloS one, 2014, Volume: 9, Issue:7

    Topics: Adult; Anticonvulsants; Case-Control Studies; Epilepsy; Estonia; Female; Humans; Male; Metabolic Syn

2014
Weight and fat distribution in patients taking valproate: a valproate-discordant gender-matched twin and sibling pair study.
    Epilepsia, 2014, Volume: 55, Issue:10

    Topics: Abdominal Fat; Absorptiometry, Photon; Adult; Anticonvulsants; Blood Pressure; Body Composition; Bod

2014
Endocrine effects of valproic acid therapy in girls with epilepsy: a prospective study.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2014, Volume: 18, Issue:6

    Topics: Adolescent; Anthropometry; Anticonvulsants; Child; Endocrine System; Epilepsy; Female; Humans; Longi

2014
An effective assessment of valproate sodium-induced hepatotoxicity with UPLC-MS and (1)HNMR-based metabonomics approach.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2014, Oct-15, Volume: 969

    Topics: Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid

2014
Asymmetric dimethylarginine and vascular risk in patients treated with antiepileptic drugs.
    Epilepsy research, 2014, Volume: 108, Issue:10

    Topics: Anticonvulsants; Aorta; Brachial Artery; Carbamazepine; Carotid Arteries; Epilepsy; Female; Humans;

2014
Risk factors of hyperammonemia in patients with epilepsy under valproic acid therapy.
    Medicine, 2014, Volume: 93, Issue:11

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Ammonia; Anticonvulsants; Antipsychotic Age

2014
Effect of comedication on lamotrigine clearance in Korean epilepsy patients.
    Clinica chimica acta; international journal of clinical chemistry, 2015, Jan-01, Volume: 438

    Topics: Adult; Anticonvulsants; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Female; Half-

2015
Clinical validation and implications of dried blood spot sampling of carbamazepine, valproic acid and phenytoin in patients with epilepsy.
    PloS one, 2014, Volume: 9, Issue:9

    Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Dried Blood Spot Testing; Drug Monitoring; Drug Therapy

2014
Degeneration and regeneration of GABAergic interneurons in the dentate gyrus of adult mice in experimental models of epilepsy.
    CNS neuroscience & therapeutics, 2015, Volume: 21, Issue:1

    Topics: Animals; Chronic Disease; Dentate Gyrus; Epilepsy; GABAergic Neurons; Glutamate Decarboxylase; Green

2015
Validation of a multigenic model to predict seizure control in newly treated epilepsy.
    Epilepsy research, 2014, Volume: 108, Issue:10

    Topics: Adult; Algorithms; Anticonvulsants; Artificial Intelligence; Australia; Biomarkers, Pharmacological;

2014
[Convulsions due to an interaction between anti-epileptic drugs and rifampicin].
    Nederlands tijdschrift voor geneeskunde, 2014, Volume: 158

    Topics: Anticonvulsants; Carbamazepine; Clonazepam; Cytochrome P-450 Enzyme System; Drug Interactions; Epile

2014
Impact of the superoxide dismutase 2 Val16Ala polymorphism on the relationship between valproic acid exposure and elevation of γ-glutamyltransferase in patients with epilepsy: a population pharmacokinetic-pharmacodynamic analysis.
    PloS one, 2014, Volume: 9, Issue:11

    Topics: Adolescent; Adult; Algorithms; Amino Acid Substitution; Anticonvulsants; Child; Child, Preschool; Ep

2014
Nonlinear mixed effects modelling approach in investigating phenobarbital pharmacokinetic interactions in epileptic patients.
    European journal of clinical pharmacology, 2015, Volume: 71, Issue:2

    Topics: Adult; Anticonvulsants; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epilepsy; Femal

2015
A population pharmacokinetic model of valproic acid in pediatric patients with epilepsy: a non-linear pharmacokinetic model based on protein-binding saturation.
    Clinical pharmacokinetics, 2015, Volume: 54, Issue:3

    Topics: Adolescent; Age Factors; Anticonvulsants; Body Weight; Carbamazepine; Child; Child, Preschool; Drug

2015
[Valproate can induce reversible encephalopathy].
    Ugeskrift for laeger, 2014, Nov-03, Volume: 176, Issue:45

    Topics: Aged; Anticonvulsants; Brain Diseases; Epilepsy; Female; Humans; Magnetic Resonance Imaging; Neuroto

2014
Response to "Asymmetric dimethylarginine and vascular risk in patients treated with antiepileptic drugs".
    Epilepsy research, 2014, Volume: 108, Issue:10

    Topics: Anticonvulsants; Aorta; Brachial Artery; Carbamazepine; Carotid Arteries; Epilepsy; Female; Humans;

2014
Correlation of saliva and serum free valproic acid concentrations in persons with epilepsy.
    Seizure, 2015, Volume: 25

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Chromatography, High Pressure Liquid; Drug Therapy,

2015
Antiepileptic treatment in a child with Landau Kleffner syndrome: a case report.
    Turk psikiyatri dergisi = Turkish journal of psychiatry, 2014,Winter, Volume: 25, Issue:4

    Topics: Anticonvulsants; Child, Preschool; Diagnosis, Differential; Epilepsy; Humans; Landau-Kleffner Syndro

2014
Extending the use of stiripentol to other epileptic syndromes: a case of PCDH19-related epilepsy.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2015, Volume: 19, Issue:2

    Topics: Age of Onset; Anticonvulsants; Autistic Disorder; Benzodiazepines; Cadherins; Child; Clobazam; Cogni

2015
[Clinical misdiagnosis analysis of valproate encephalopathy].
    Zhonghua yi xue za zhi, 2014, Sep-09, Volume: 94, Issue:33

    Topics: Anticonvulsants; Brain Diseases; Brain Edema; Brain Neoplasms; Diagnostic Errors; Epilepsy; Humans;

2014
Cosmetic side effects of antiepileptic drugs in adults with epilepsy.
    Epilepsy & behavior : E&B, 2015, Volume: 42

    Topics: Acne Vulgaris; Adult; Alopecia; Anticonvulsants; Epilepsy; Female; gamma-Aminobutyric Acid; Gingival

2015
Effects of phenytoin and valproic acid on cognitive functions of Thai epileptic patients: a pilot study.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2014, Volume: 97 Suppl 2

    Topics: Adolescent; Adult; Anticonvulsants; Asian People; Carbamazepine; Case-Control Studies; Cognition; Ep

2014
IQ at 6 years after in utero exposure to antiepileptic drugs: a controlled cohort study.
    Neurology, 2015, Jan-27, Volume: 84, Issue:4

    Topics: Adult; Anticonvulsants; Carbamazepine; Child; Child Development; Epilepsy; Female; Humans; Intellige

2015
Fine-tuning risk assessment with antiepileptic drug use in pregnancy.
    Neurology, 2015, Jan-27, Volume: 84, Issue:4

    Topics: Anticonvulsants; Carbamazepine; Child Development; Epilepsy; Female; Humans; Intelligence; Lamotrigi

2015
Carnitine deficiency: Risk factors and incidence in children with epilepsy.
    Brain & development, 2015, Volume: 37, Issue:8

    Topics: Adolescent; Anticonvulsants; Cardiomyopathies; Carnitine; Case-Control Studies; Child; Child, Presch

2015
Valproate fetopathy.
    Journal of perinatology : official journal of the California Perinatal Association, 2015, Volume: 35, Issue:1

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Diagnostic Imaging; Epilepsy; Female; Fetal Di

2015
Pharmacological interaction between valproic acid and carbapenem: what about levels in pediatrics?
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2015, Volume: 19, Issue:2

    Topics: Adolescent; Anticonvulsants; Carbapenems; Child; Child, Preschool; Drug Interactions; Drug Therapy,

2015
Comparative behavioral and neurochemical analysis of phenytoin and valproate treatment on epilepsy induced learning and memory deficit: Search for add on therapy.
    Metabolic brain disease, 2015, Volume: 30, Issue:4

    Topics: Acetylcholinesterase; Animals; Anticonvulsants; Cerebral Cortex; Drug Therapy, Combination; Epilepsy

2015
Standard dose valproic acid does not cause additional cognitive impact in a rodent model of intractable epilepsy.
    Epilepsy research, 2015, Volume: 110

    Topics: Animals; Animals, Newborn; Anticonvulsants; Cognition; Cognition Disorders; Disease Models, Animal;

2015
A granulocytosis associated with rufinamide: A case report.
    Brain & development, 2015, Volume: 37, Issue:8

    Topics: Agranulocytosis; Anticonvulsants; Child; Clonazepam; Epilepsy; Humans; Male; Triazoles; Valproic Aci

2015
Valproate and pregnancy: think again.
    Neurology, 2015, Jan-27, Volume: 84, Issue:4

    Topics: Anticonvulsants; Carbamazepine; Child Development; Epilepsy; Female; Humans; Intelligence; Lamotrigi

2015
The effects of antiepileptic drug valproic acid on apoptosis of hippocampal neurons in epileptic rats.
    Pakistan journal of pharmaceutical sciences, 2015, Volume: 28, Issue:1 Suppl

    Topics: Animals; Anticonvulsants; Apoptosis; bcl-2-Associated X Protein; Electroencephalography; Epilepsy; H

2015
Seminal fluid analysis and testicular volume in adults with epilepsy receiving valproate.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2015, Volume: 22, Issue:3

    Topics: Adult; Anticonvulsants; Epilepsy; Humans; Male; Organ Size; Semen; Sperm Count; Sperm Motility; Sper

2015
Association of LEPR and ANKK1 Gene Polymorphisms with Weight Gain in Epilepsy Patients Receiving Valproic Acid.
    The international journal of neuropsychopharmacology, 2015, Mar-03, Volume: 18, Issue:7

    Topics: Adolescent; Adult; AMP-Activated Protein Kinases; Anticonvulsants; Body Weight; Chromatography, High

2015
Effects of chronic administration of valproic acid to epileptic patients on coagulation tests and primary hemostasis.
    Epilepsia, 2015, Volume: 56, Issue:5

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adolescent; Adult; Anticonvulsants; Blood Coagulation

2015
Endocrine Effects of Valproate versus Carbamazepine in Males with Epilepsy: A Prospective Study.
    Hormone research in paediatrics, 2015, Volume: 83, Issue:5

    Topics: Adolescent; Anticonvulsants; Body Height; Body Weight; Carbamazepine; Child; Epilepsy; Humans; Male;

2015
Valproate-induced enuresis: a prospective study.
    Developmental medicine and child neurology, 2015, Volume: 57, Issue:8

    Topics: Age Factors; Anticonvulsants; Child; Child, Preschool; Enuresis; Epilepsy; Female; Humans; Male; Pro

2015
Antiepileptic drugs in Rett Syndrome.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2015, Volume: 19, Issue:4

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Lamotrigine; Male

2015
[Use of valproic acid in long stay units of psychiatry].
    Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria, 2015, Mar-01, Volume: 39, Issue:2

    Topics: Adult; Aged; Antimanic Agents; Bipolar Disorder; Cross-Sectional Studies; Epilepsy; Female; Humans;

2015
Reduction of epileptiform activity by valproic acid in a mouse model of Alzheimer's disease is not long-lasting after treatment discontinuation.
    Epilepsy research, 2015, Volume: 112

    Topics: Acetylation; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Anti

2015
Analysis of variability of concentrations of valproic acid (VPA) and its selected metabolites in the blood serum of patients treated with VPA and patients hospitalized because of VPA poisoning.
    Archiwum medycyny sadowej i kryminologii, 2014, Volume: 64, Issue:4

    Topics: Anticonvulsants; Bipolar Disorder; Drug Overdose; Epilepsy; Female; Humans; Male; Peripheral Nervous

2014
Effects of antiepileptic drug monotherapy on one-carbon metabolism and DNA methylation in patients with epilepsy.
    PloS one, 2015, Volume: 10, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Case-Control Studies; Cross-Sectional Studies; DNA Methylation;

2015
Effects of UGT1A4 genetic polymorphisms on serum lamotrigine concentrations in Chinese children with epilepsy.
    Drug metabolism and pharmacokinetics, 2015, Volume: 30, Issue:3

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; China; Drug Interactions; Drug Therapy, Combin

2015
Clinical significance of CYP2C9-status guided valproic acid therapy in children.
    Epilepsia, 2015, Volume: 56, Issue:6

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Cytochrome P-450 CYP2C9; Drug-Related Side Eff

2015
An Evaluation of Peripapillary Retinal Nerve Fiber Layer Thickness in Children With Epilepsy Receiving Treatment of Valproic Acid.
    Pediatric neurology, 2015, Volume: 53, Issue:1

    Topics: Adolescent; Anticonvulsants; Child; Epilepsy; Eye; Female; Humans; Male; Organ Size; Tomography, Opt

2015
Commentary: Valproate in the treatment of epilepsy in women and girls: The need for recommendations.
    Epilepsia, 2015, Volume: 56, Issue:7

    Topics: Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Valproic Acid

2015
Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models.
    Naunyn-Schmiedeberg's archives of pharmacology, 2015, Volume: 388, Issue:10

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Docosahexaenoic Acids; Dose-Response Relationship,

2015
A prospective study of adverse drug reactions to antiepileptic drugs in children.
    BMJ open, 2015, Jun-01, Volume: 5, Issue:6

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cognition Disorders; Drug Thera

2015
Epilepsy in children with tuberous sclerosis complex: Chance of remission and response to antiepileptic drugs.
    Epilepsia, 2015, Volume: 56, Issue:8

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diet, Ketogenic; Epilepsies, Partial; Epilepsy

2015
Commentary: Revised recommendation from CMDh on use of valproate in women is ethically incomplete and neglects the interests of women.
    Epilepsia, 2015, Volume: 56, Issue:7

    Topics: Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Valproic Acid

2015
Muscle Weakness and Pain With Profound Hypophosphatemia: Mystery Revealed.
    Clinical pediatrics, 2015, Volume: 54, Issue:10

    Topics: Adolescent; Epilepsy; Fanconi Syndrome; Humans; Hypophosphatemia; Male; Muscle Weakness; Valproic Ac

2015
Dose-dependent teratogenicity of valproate in mono- and polytherapy: an observational study.
    Neurology, 2015, Sep-08, Volume: 85, Issue:10

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Dose-Response Relationship, Drug; D

2015
The influence of UGT2B7 genotype on valproic acid pharmacokinetics in Chinese epilepsy patients.
    Epilepsy research, 2015, Volume: 114

    Topics: Adult; Alleles; Anticonvulsants; Asian People; Epilepsy; Female; Genotype; Glucuronosyltransferase;

2015
Effect of Carbamazepine and Valproate Monotherapy on Cardiovascular Risks in Epileptic Children.
    Pediatric neurology, 2015, Volume: 53, Issue:1

    Topics: Anticonvulsants; Apolipoproteins A; Apolipoproteins B; Blood Chemical Analysis; Carbamazepine; Cardi

2015
Involvement of p38 MAPK in the Drug Resistance of Refractory Epilepsy Through the Regulation Multidrug Resistance-Associated Protein 1.
    Neurochemical research, 2015, Volume: 40, Issue:7

    Topics: Animals; Chromatography, High Pressure Liquid; Drug Resistance; Epilepsy; Lamotrigine; Male; Microdi

2015
Changes in the anti-oxidant system in adult epilepsy patients receiving anti-epileptic drugs.
    Archives of physiology and biochemistry, 2015, Volume: 121, Issue:3

    Topics: Acetylcholinesterase; Adult; Anticonvulsants; Antioxidants; Aryldialkylphosphatase; Carbamazepine; C

2015
Valproate still has a place in women with epilepsy.
    Epilepsia, 2015, Volume: 56, Issue:7

    Topics: Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Valproic Acid

2015
Recurrent seizures during acute acquired toxoplasmosis in an immunocompetent traveller returning from Africa.
    Infection, 2016, Volume: 44, Issue:2

    Topics: Adolescent; Antibodies, Protozoan; Anticonvulsants; Antiprotozoal Agents; Epilepsy; Ethiopia; Humans

2016
Impact of epilepsy and antiepileptic medications on the metabolic profile in adults with autism spectrum disorder and intellectual disabilities.
    International clinical psychopharmacology, 2015, Volume: 30, Issue:6

    Topics: Adult; Anticonvulsants; Autism Spectrum Disorder; Blood Glucose; Body Mass Index; Carbamazepine; Cho

2015
Dynamics of hydroxyoctadecadienoic acid in epilepsy patients treated with valproic acid.
    Pediatrics international : official journal of the Japan Pediatric Society, 2016, Volume: 58, Issue:1

    Topics: Adolescent; Anticonvulsants; Biomarkers; Child; Child, Preschool; Epilepsy; Fatty Acids, Unsaturated

2016
Reduction of epileptiform activity through local valproate-implants in a rat neocortical epilepsy model.
    Seizure, 2015, Volume: 30

    Topics: Animals; Anticonvulsants; Cobalt; Disease Models, Animal; Drug Implants; Electrocorticography; Elect

2015
Epileptogenesis and epileptic maturation in phosphorylation site-specific SNAP-25 mutant mice.
    Epilepsy research, 2015, Volume: 115

    Topics: Animals; Anticonvulsants; Anxiety; Blotting, Western; Brain; Disease Progression; Electrocorticograp

2015
Cytochrome P450 2C19 polymorphisms and valproic acid-induced weight gain.
    Acta neurologica Scandinavica, 2016, Volume: 133, Issue:3

    Topics: Adolescent; Anticonvulsants; Body Mass Index; Carbamazepine; Child; Cytochrome P-450 CYP2C19; Epilep

2016
Valproate modulates glucose metabolism in patients with epilepsy after first exposure.
    Epilepsia, 2015, Volume: 56, Issue:11

    Topics: Adolescent; Adult; Anticonvulsants; Blood Glucose; Cross-Over Studies; Epilepsy; Female; Glucose; Hu

2015
The investigation of EEG specificity in epileptic children during Depakine therapy.
    The International journal of neuroscience, 2016, Volume: 126, Issue:10

    Topics: Anticonvulsants; Brain Waves; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Outcome Asses

2016
[The prevalence of obesity and metabolic syndrome in paediatric patients with epilepsy treated in monotherapy with valproic acid].
    Revista de neurologia, 2015, Sep-01, Volume: 61, Issue:5

    Topics: Adolescent; Anticonvulsants; Child; Cross-Sectional Studies; Epilepsy; Female; Humans; Male; Metabol

2015
A LC-MS/MS method for therapeutic drug monitoring of carbamazepine, lamotrigine and valproic acid in DBS.
    Bioanalysis, 2015, Volume: 7, Issue:16

    Topics: Anticonvulsants; Calibration; Carbamazepine; Child; Chromatography, Liquid; Dried Blood Spot Testing

2015
[Valproic acid responsible for low IQ].
    MMW Fortschritte der Medizin, 2015, Sep-10, Volume: 157, Issue:15

    Topics: Anticonvulsants; Carbamazepine; Child Development; Epilepsy; Female; Humans; Intelligence; Male; Pre

2015
Changing incidence of hyperammonemia in Japan from 2006 to 2013: expansion of new antiepileptic drugs reduces the risk of hyperammonemia.
    European journal of clinical pharmacology, 2015, Volume: 71, Issue:12

    Topics: Adolescent; Adult; Anticonvulsants; Child; Drug Interactions; Drug Therapy, Combination; Epilepsy; F

2015
Trends in Antiepileptic Drug Prescriptions for Childhood Epilepsy at a Tertiary Children's Hospital in Korea, 2001-2012.
    Paediatric drugs, 2015, Volume: 17, Issue:6

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Prescriptions; Epilepsy; F

2015
Prognostic relevance of epilepsy at presentation in glioblastoma patients.
    Neuro-oncology, 2016, Volume: 18, Issue:5

    Topics: Adult; Anticonvulsants; Brain Neoplasms; Epilepsy; Female; Glioblastoma; Humans; Immunohistochemistr

2016
Effects of CYP3A4/5 and ABCB1 genetic polymorphisms on carbamazepine metabolism and transport in Chinese patients with epilepsy treated with carbamazepine in monotherapy and bitherapy.
    Epilepsy research, 2015, Volume: 117

    Topics: Adolescent; Adult; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; Carbamazepine; Ch

2015
Evaluate the Effect of Valproate Monotherapy on the Serum Homocysteine, Folate and Vitamin B12 Levels in Epileptic Children.
    Clinical laboratory, 2015, Volume: 61, Issue:8

    Topics: Adolescent; Age Factors; Anticonvulsants; Case-Control Studies; Child; Child, Preschool; Drug Monito

2015
[Position Statement of Hungarian Epilepsy League: The use of valproate preparations for epilepsy in pregnancy and in women of childbearing age].
    Ideggyogyaszati szemle, 2015, Mar-30, Volume: 68, Issue:3-4

    Topics: Adolescent; Adult; Anticonvulsants; Cognition; Contraception; Dose-Response Relationship, Drug; Drug

2015
Fine-tuning risk assessment with antiepileptic drug use in pregnancy.
    Neurology, 2015, Oct-13, Volume: 85, Issue:15

    Topics: Anticonvulsants; Carbamazepine; Child Development; Epilepsy; Female; Humans; Intelligence; Male; Pre

2015
Determination of the Optimal Concentration of Valproic Acid in Patients with Epilepsy: A Population Pharmacokinetic-Pharmacodynamic Analysis.
    PloS one, 2015, Volume: 10, Issue:10

    Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Child, Preschool; Drug Interactions; Epileps

2015
Serum levels of valproic acid during delivery in mothers and in umbilical cord - correlation with birth length and weight.
    Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, 2015, Volume: 159, Issue:4

    Topics: Anticonvulsants; Biomarkers; Body Height; Body Weight; Delivery, Obstetric; Dose-Response Relationsh

2015
[Valproate can induce reversible encephalopathy].
    Ugeskrift for laeger, 2015, May-11, Volume: 177, Issue:20

    Topics: Aged; Anticonvulsants; Brain Diseases; Epilepsy; Female; Humans; Magnetic Resonance Imaging; Neuroto

2015
Influence of glutamine synthetase gene polymorphisms on the development of hyperammonemia during valproic acid-based therapy.
    Seizure, 2015, Volume: 33

    Topics: Adolescent; Ammonia; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Genotype; Glutamate

2015
[Meropenem and valproic acid: A clinically relevant drug-drug interaction].
    Enfermedades infecciosas y microbiologia clinica, 2016, Volume: 34, Issue:8

    Topics: Adult; Anti-Bacterial Agents; Anticonvulsants; Drug Interactions; Epilepsy; Female; Fructose; Humans

2016
Specific adverse effects of antiepileptic drugs--A true-to-life monotherapy study.
    Epilepsy & behavior : E&B, 2016, Volume: 54

    Topics: Adult; Aged; Anticonvulsants; Anxiety; Carbamazepine; Depression; Drug-Related Side Effects and Adve

2016
Effects of UGT2B7 Genetic Polymorphisms on Serum Concentrations of Valproic Acid in Chinese Children With Epilepsy Comedicated With Lamotrigine.
    Therapeutic drug monitoring, 2016, Volume: 38, Issue:3

    Topics: Adolescent; Age Factors; Anticonvulsants; Asian People; Child; Child, Preschool; Chromatography, Hig

2016
The COL1A1 SP1 polymorphism is associated with lower bone mineral density in patients treated with valproic acid.
    Pharmacogenetics and genomics, 2016, Volume: 26, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Bone Density; Collagen Type I; Collagen Type I, alp

2016
Use of antiepileptic drugs during pregnancy and lactation: Type of information provided by searching Google.
    Epilepsy & behavior : E&B, 2016, Volume: 55

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans

2016
Does Valproic Acid or Levetiracetam Improve Survival in Glioblastoma? A Pooled Analysis of Prospective Clinical Trials in Newly Diagnosed Glioblastoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016, Mar-01, Volume: 34, Issue:7

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemor

2016
Auditory hallucinations preceding migraine, differentiation with epileptic origin: A case report.
    Schizophrenia research, 2016, Volume: 172, Issue:1-3

    Topics: Adult; Anticonvulsants; Brain; Diagnosis, Differential; Epilepsy; Follow-Up Studies; Hallucinations;

2016
Outcome of renal proximal tubular dysfunction with Fanconi syndrome caused by sodium valproate.
    Pediatrics international : official journal of the Japan Pediatric Society, 2016, Volume: 58, Issue:10

    Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Fanconi Syndrome; Female; Follow-Up Studies; Hum

2016
Prescribing trends for sodium valproate in Ireland.
    Seizure, 2016, Volume: 36

    Topics: Adolescent; Adult; Anticonvulsants; Drug Prescriptions; Epilepsy; Female; Folic Acid; Humans; Irelan

2016
Factors influencing topiramate clearance in adult patients with epilepsy: A population pharmacokinetic analysis.
    Seizure, 2016, Volume: 37

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fructose; Humans; Male; M

2016
Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures.
    Epilepsy & behavior : E&B, 2016, Volume: 57, Issue:Pt A

    Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistance; Epilepsy; GABA Antagoni

2016
[A girl with foetal valproate syndrome and autism spectrum disorder].
    Tijdschrift voor psychiatrie, 2016, Volume: 58, Issue:3

    Topics: Anticonvulsants; Autistic Disorder; Child; Child Development Disorders, Pervasive; Epilepsy; Female;

2016
Various simultaneous nail changes due to valproic acid use.
    Cutaneous and ocular toxicology, 2017, Volume: 36, Issue:1

    Topics: Anticonvulsants; Epilepsy; Humans; Male; Middle Aged; Nails; Pigmentation; Valproic Acid

2017
Concentrations of carbamazepine and carbamazepine-10,11-epoxide in maternal and umbilical cord blood at birth: Influence of co-administration of valproic acid or enzyme-inducing antiepileptic drugs.
    Epilepsy research, 2016, Volume: 122

    Topics: Adolescent; Adult; Anticonvulsants; Blood Chemical Analysis; Carbamazepine; Dose-Response Relationsh

2016
Weight gain in children on oxcarbazepine monotherapy.
    Epilepsy research, 2016, Volume: 122

    Topics: Adolescent; Anticonvulsants; Body Mass Index; Carbamazepine; Child; Child, Preschool; Epilepsy; Fema

2016
France steps up warning measures for valproate drugs.
    Lancet (London, England), 2016, Mar-19, Volume: 387, Issue:10024

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Drug and Narcotic Control; Drug Information Services;

2016
The effects of co-medications on lamotrigine clearance in Japanese children with epilepsy.
    Brain & development, 2016, Volume: 38, Issue:8

    Topics: Adolescent; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Child, Preschool; Clobazam; Clon

2016
Considering Valproate as a Risk Factor for Rapid Exacerbation of Complex Movement Disorder in Progressed Stages of Late-Infantile CLN2 Disease.
    Neuropediatrics, 2016, Volume: 47, Issue:3

    Topics: Anticonvulsants; Child; Child, Preschool; Consciousness Disorders; Creatine Kinase; Deprescriptions;

2016
Metabolic syndrome and anticonvulsants: A comparative study of valproic acid and carbamazepine.
    Seizure, 2016, Volume: 38

    Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Male; Metabolic Syndrome; Mid

2016
Serum levels of zinc and copper in epileptic children during long-term therapy with anticonvulsants.
    Neurosciences (Riyadh, Saudi Arabia), 2016, Volume: 21, Issue:2

    Topics: Anticonvulsants; Child; Copper; Epilepsy; Humans; Valproic Acid; Zinc

2016
Duration of valproic acid monotherapy correlates with subclinical thyroid dysfunction in children with epilepsy.
    Epileptic disorders : international epilepsy journal with videotape, 2016, Jun-01, Volume: 18, Issue:2

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Cross-Sectional Studies; Epilepsy; Female; Hum

2016
An investigation of the influence of patient-related factors and comedications on lamotrigine clearance in patients with epilepsy.
    Clinical and experimental pharmacology & physiology, 2016, Volume: 43, Issue:7

    Topics: Adult; Anticonvulsants; Body Weight; Dose-Response Relationship, Drug; Drug Interactions; Drug Thera

2016
Medication prescribing and patient-reported outcome measures in people with epilepsy in Bhutan.
    Epilepsy & behavior : E&B, 2016, Volume: 59

    Topics: Adult; Aged; Anticonvulsants; Bhutan; Carbamazepine; Drug Prescriptions; Electroencephalography; Epi

2016
Should women of childbearing potential be prescribed valproate? a call to action.
    The Journal of clinical psychiatry, 2016, Volume: 77, Issue:4

    Topics: Abnormalities, Drug-Induced; Bipolar Disorder; Contraception Behavior; Epilepsy; Female; Humans; Inf

2016
Potential effects of valproate and oxcarbazepine on growth velocity and bone metabolism in epileptic children- a medical center experience.
    BMC pediatrics, 2016, 05-03, Volume: 16

    Topics: Adolescent; Anticonvulsants; Bone Remodeling; Carbamazepine; Case-Control Studies; Child; Child, Pre

2016
Bone health and vitamin D status in young epilepsy patients on valproate monotherapy.
    Clinical neurology and neurosurgery, 2016, Volume: 146

    Topics: Adult; Anticonvulsants; Bone Density; Cohort Studies; Epilepsy; Female; Humans; Male; Valproic Acid;

2016
Adjuvant indoleamine 2,3-dioxygenase enzyme inhibition for comprehensive management of epilepsy and comorbid depression.
    European journal of pharmacology, 2016, Aug-05, Volume: 784

    Topics: Animals; Comorbidity; Corticosterone; Depression; Drug Interactions; Enzyme Inhibitors; Epilepsy; Hi

2016
Differential impact of contraceptive methods on seizures varies by antiepileptic drug category: Findings of the Epilepsy Birth Control Registry.
    Epilepsy & behavior : E&B, 2016, Volume: 60

    Topics: Adult; Anticonvulsants; Contraception; Contraceptive Agents; Contraceptives, Oral, Hormonal; Epileps

2016
Comparison of body composition in persons with epilepsy on conventional & new antiepileptic drugs.
    The Indian journal of medical research, 2016, Volume: 143, Issue:3

    Topics: Adult; Anticonvulsants; Benzodiazepines; Body Composition; Body Water; Body Weight; Carbamazepine; C

2016
Antiepileptic drug combinations not involving valproate and the risk of fetal malformations.
    Epilepsia, 2016, Volume: 57, Issue:7

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cohort Studies; Dose-Response Relationship, Drug; Drug

2016
Withdrawal of valproic acid treatment during pregnancy and seizure outcome: Observations from EURAP.
    Epilepsia, 2016, Volume: 57, Issue:8

    Topics: Adolescent; Adult; Anticonvulsants; Bayes Theorem; Cohort Studies; Epilepsy; Female; Humans; Interna

2016
Patterns of antiepileptic drugs use in epileptic pediatric patients in Jordan.
    Neurosciences (Riyadh, Saudi Arabia), 2016, Volume: 21, Issue:3

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cross-Sectional Studies; Drug T

2016
Influence of acylpeptide hydrolase polymorphisms on valproic acid level in Chinese epilepsy patients.
    Pharmacogenomics, 2016, Volume: 17, Issue:11

    Topics: Adult; Anticonvulsants; Asian People; Epilepsy; Female; Genotype; Glucuronosyltransferase; Humans; M

2016
Steady-state pharmacokinetic simulation of intermittent vs. continuous infusion valproic acid therapy in non-critically ill and critically ill patients.
    Neurological research, 2016, Volume: 38, Issue:9

    Topics: Adult; Anticonvulsants; Cohort Studies; Critical Illness; Dose-Response Relationship, Drug; Drug Adm

2016
Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment.
    Epilepsy research, 2016, Volume: 126

    Topics: Animals; Anticonvulsants; Brain; Callithrix; Carbamazepine; Chronic Disease; Disease Models, Animal;

2016
Fetal Valproate Syndrome.
    Pediatrics and neonatology, 2017, Volume: 58, Issue:2

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child, Preschool; Craniofacial Abnormalities; Cryptorc

2017
Evidence in support of using a neurochemistry approach to identify therapy for both epilepsy and associated depression.
    Epilepsy & behavior : E&B, 2016, Volume: 61

    Topics: Animals; Anticonvulsants; Brain; Depression; Depressive Disorder; Disease Models, Animal; Dopamine;

2016
Clinical features of patients with game-induced seizures in the Chinese population.
    Seizure, 2016, Volume: 41

    Topics: Adolescent; Adult; Age Distribution; Anticonvulsants; Asian People; Child; Electroencephalography; E

2016
In response: Commentary on clinical significance of CYP2C9-status-guided valproic acid therapy in children.
    Epilepsia, 2016, Volume: 57, Issue:8

    Topics: Anticonvulsants; Child; Cytochrome P-450 CYP2C9; Epilepsy; Female; Humans; Hyperammonemia; Male; Val

2016
Resting-state fMRI revealed different brain activities responding to valproic acid and levetiracetam in benign epilepsy with central-temporal spikes.
    European radiology, 2017, Volume: 27, Issue:5

    Topics: Anticonvulsants; Brain; Child; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; F

2017
The consequences of valproate exposure in utero.
    Journal of neurology, 2016, Volume: 263, Issue:9

    Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Prenatal Exposure Delayed Effects; Valproic Acid

2016
Cognition in school-age children exposed to levetiracetam, topiramate, or sodium valproate.
    Neurology, 2016, Nov-01, Volume: 87, Issue:18

    Topics: Adult; Anticonvulsants; Child; Cognition Disorders; Cross-Sectional Studies; Epilepsy; Female; Follo

2016
Comparative persistence of antiepileptic drugs in patients with epilepsy: A STROBE-compliant retrospective cohort study.
    Medicine, 2016, Volume: 95, Issue:35

    Topics: Adolescent; Adult; Aged; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilep

2016
Does valproate therapy in epileptic patients contribute to changing atherosclerosis risk factors? The role of lipids and free fatty acids.
    Pharmacological reports : PR, 2016, Volume: 68, Issue:6

    Topics: Adult; Atherosclerosis; Cohort Studies; Cross-Sectional Studies; Epilepsy; Fatty Acids, Nonesterifie

2016
Efficacy and tolerability of anti-epileptic drugs-an internet study.
    Acta neurologica Scandinavica, 2017, Volume: 135, Issue:5

    Topics: Adult; Anticonvulsants; Carbamazepine; Depression; Epilepsy; Female; Humans; Internet; Lamotrigine;

2017
Serious and reversible levetiracetam-induced psychiatric symptoms after resection of frontal low-grade glioma: two case histories.
    British journal of neurosurgery, 2017, Volume: 31, Issue:4

    Topics: Anticonvulsants; Brain Neoplasms; Craniotomy; Epilepsy; Frontal Lobe; Humans; Levetiracetam; Magneti

2017
Women are unaware of pregnancy risks linked with sodium valproate.
    BMJ (Clinical research ed.), 2016, Oct-30, Volume: 355

    Topics: Anticonvulsants; Developmental Disabilities; Epilepsy; Female; Health Knowledge, Attitudes, Practice

2016
[Caution and warning: About valproate and pregnancy].
    L'Encephale, 2016, Volume: 42, Issue:5

    Topics: Adult; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Epilepsy; Female; Humans; Pregnancy; Pre

2016
Effects of UGT1A6 and GABRA1 on Standardized Valproic Acid Plasma Concentrations and Treatment Effect in Children With Epilepsy in China.
    Therapeutic drug monitoring, 2016, Volume: 38, Issue:6

    Topics: Adolescent; Age Factors; Anticonvulsants; Asian People; Child; Child, Preschool; China; Dose-Respons

2016
Status epilepticus in pregnant women with epilepsy after valproate adjustment: A case series.
    Seizure, 2016, Volume: 43

    Topics: Adult; Anticonvulsants; Electroencephalography; Epilepsy; Female; Humans; Pregnancy; Retrospective S

2016
Polymorphisms of ABAT, SCN2A and ALDH5A1 may affect valproic acid responses in the treatment of epilepsy in Chinese.
    Pharmacogenomics, 2016, Volume: 17, Issue:18

    Topics: 4-Aminobutyrate Transaminase; Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female

2016
Adjuvant neuronal nitric oxide synthase inhibition for combined treatment of epilepsy and comorbid depression.
    Pharmacological reports : PR, 2017, Volume: 69, Issue:1

    Topics: Animals; Anticonvulsants; Chemotherapy, Adjuvant; Depression; Dose-Response Relationship, Drug; Enzy

2017
Antiepileptic drugs in migraine and epilepsy: Who is at increased risk of adverse events?
    Cephalalgia : an international journal of headache, 2018, Volume: 38, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Child; Epilepsy; Female; Humans; Lamotr

2018
Effectiveness and tolerability of antiepileptic drugs in 104 girls with Rett syndrome.
    Epilepsy & behavior : E&B, 2017, Volume: 66

    Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Therap

2017
Simultaneous Determination of Valproic Acid and Its Major Metabolites by UHPLC-MS/MS in Chinese Patients: Application to Therapeutic Drug Monitoring.
    Journal of chromatographic science, 2017, Apr-01, Volume: 55, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; China; Chromatography, High Pressure Li

2017
Cognitive functions in children exposed to antiepileptic drugs in utero - Study in Georgia.
    Epilepsy & behavior : E&B, 2017, Volume: 66

    Topics: Adult; Anticonvulsants; Child; Child Development; Child, Preschool; Cognition; Cohort Studies; Epile

2017
Combining adverse pregnancy and perinatal outcomes for women exposed to antiepileptic drugs during pregnancy, using a latent trait model.
    BMC pregnancy and childbirth, 2017, 01-06, Volume: 17, Issue:1

    Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Epilepsy; Female; Florida; Humans; Infant, Low

2017
Prenatal exposure to antiepileptic drugs and use of primary healthcare during childhood: a population-based cohort study in Denmark.
    BMJ open, 2017, 01-05, Volume: 7, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Denmark; Epilepsy; Femal

2017
Sulforaphane protects against sodium valproate-induced acute liver injury.
    Canadian journal of physiology and pharmacology, 2017, Volume: 95, Issue:4

    Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Anticonvulsants; A

2017
[Therapeutic drug monitoring of three antiepileptic drugs - Back on twenty years of experience].
    The Pan African medical journal, 2016, Volume: 25

    Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Monitoring; Epilepsy; Humans;

2016
Associations between genetic variation in one-carbon metabolism and leukocyte DNA methylation in valproate-treated patients with epilepsy.
    Clinical nutrition (Edinburgh, Scotland), 2018, Volume: 37, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Case-Control Studies; DNA Methylation; Epilepsy; Female; Humans;

2018
Valproate acid (VPA)-induced dysmetabolic function in clinical and animal studies.
    Clinica chimica acta; international journal of clinical chemistry, 2017, Volume: 468

    Topics: Adipose Tissue; Adult; Anticonvulsants; Epilepsy; Fatty Acid-Binding Proteins; Female; Gene Expressi

2017
Trimetazidine potentiates the antiepileptic activity and ameliorates the metabolic changes associated with pentylenetetrazole kindling in rats treated with valproic acid.
    Canadian journal of physiology and pharmacology, 2017, Volume: 95, Issue:6

    Topics: Animals; Anticonvulsants; Aorta; Biomarkers; Blood Glucose; Drug Synergism; Epilepsy; Hippocampus; I

2017
Comparison of LC-MS/MS vs chemiluminescent microparticle immunoassay in measuring the valproic acid concentration in plasma of epilepsy patients in a new perspective.
    Journal of clinical laboratory analysis, 2018, Volume: 32, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Cell Line; Child; Child, Preschool; Chr

2018
An investigation of the characteristics of outpatients with epilepsy and antiepileptic drug utilization in a multicenter cross-sectional study in China.
    Epilepsy & behavior : E&B, 2017, Volume: 69

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; China; Cross-Sectional Studies; Drug Combin

2017
Drug interaction between valproic acid and carbapenems in patients with epileptic seizures.
    The Kaohsiung journal of medical sciences, 2017, Volume: 33, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anticonvulsants; Bacterial Infections; Carbap

2017
Associations of CYP2C9 and CYP2A6 Polymorphisms with the Concentrations of Valproate and its Hepatotoxin Metabolites and Valproate-Induced Hepatotoxicity.
    Basic & clinical pharmacology & toxicology, 2017, Volume: 121, Issue:2

    Topics: Adolescent; Adult; Alleles; Anticonvulsants; Biotransformation; Chemical and Drug Induced Liver Inju

2017
Hemodiafiltration and high-flux hemodialysis significantly reduce serum valproate levels inducing epileptic seizures: case report.
    Blood purification, 2008, Volume: 26, Issue:4

    Topics: Adult; Epilepsy; Female; Hemodiafiltration; Humans; Levetiracetam; Piracetam; Renal Dialysis; Valpro

2008
[Influence of age, body weight and dose on sodium valproate plasma concentrations in children with epilepsy].
    Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2008, Volume: 10, Issue:3

    Topics: Age Factors; Anticonvulsants; Body Weight; Child; Child, Preschool; Epilepsy; Female; Humans; Infant

2008
Valproate teratogenicity and epilepsy syndrome.
    Epilepsia, 2008, Volume: 49, Issue:12

    Topics: Abnormalities, Drug-Induced; Age of Onset; Analysis of Variance; Anticonvulsants; Dose-Response Rela

2008
States of serum leptin and insulin in children with epilepsy: risk predictors of weight gain.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2009, Volume: 13, Issue:3

    Topics: Adolescent; Age Factors; Anticonvulsants; Body Mass Index; Carbamazepine; Case-Control Studies; Chil

2009
Antiepileptic drug utilization in children from 1997-2005--a study from the Netherlands.
    European journal of clinical pharmacology, 2008, Volume: 64, Issue:10

    Topics: Anticonvulsants; Carbamazepine; Child; Databases, Factual; Drug Utilization; Epilepsy; Female; Human

2008
Drug-induced pertubation of the aminothiol redox-status in patients with epilepsy: improvement by B-vitamins.
    Epilepsy research, 2008, Volume: 82, Issue:1

    Topics: Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Cysteine; Dipeptides; Drug Evaluation;

2008
Tetramethylcyclopropyl analogue of the leading antiepileptic drug, valproic acid: evaluation of the teratogenic effects of its amide derivatives in NMRI mice.
    Birth defects research. Part A, Clinical and molecular teratology, 2008, Volume: 82, Issue:9

    Topics: Abnormalities, Drug-Induced; Amides; Animals; Anticonvulsants; Benzenesulfonamides; Cyclopropanes; D

2008
DNA topoisomerase I inhibitors ameliorate seizure-like behaviors and paralysis in a Drosophila model of epilepsy.
    Neuroscience, 2008, Oct-15, Volume: 156, Issue:3

    Topics: Analysis of Variance; Animals; Animals, Genetically Modified; Bromates; Camptothecin; Disease Models

2008
Clonally expanded mitochondrial DNA mutations in epileptic individuals with mutated DNA polymerase gamma.
    Journal of neuropathology and experimental neurology, 2008, Volume: 67, Issue:9

    Topics: Adolescent; Anticonvulsants; Brain; Child; Child, Preschool; Diffuse Cerebral Sclerosis of Schilder;

2008
Lack of valproic acid-associated weight gain in prepubertal children.
    Pediatric neurology, 2008, Volume: 39, Issue:3

    Topics: Adolescent; Anticonvulsants; Body Height; Body Mass Index; Body Weight; Carbamazepine; Child; Child,

2008
Perspectives on interactions between antiepileptic drugs (AEDs) and antimicrobial agents.
    Epilepsia, 2008, Volume: 49 Suppl 6

    Topics: Aged; Anti-Infective Agents; Anticonvulsants; Brain Abscess; Drug Interactions; Epilepsy; Female; He

2008
Association of lamotrigine and valproate in refractory epilepsies of children and adolescents.
    Arquivos de neuro-psiquiatria, 2008, Volume: 66, Issue:3A

    Topics: Adolescent; Age Distribution; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; E

2008
The effects of biotin supplementation on serum and liver tissue biotinidase enzyme activity and alopecia in rats which were administrated to valproic acid.
    Brain & development, 2009, Volume: 31, Issue:6

    Topics: Alopecia; Animals; Anticonvulsants; Avitaminosis; Biotin; Biotinidase; Biotinidase Deficiency; Dieta

2009
Does ghrelin really increase in epileptic children treated with valproate?
    Journal of child neurology, 2008, Volume: 23, Issue:9

    Topics: Anticonvulsants; Child; Clinical Laboratory Techniques; Epilepsy; Ghrelin; Humans; Molecular Weight;

2008
The influence of valproic acid treatment on hair and serum zinc levels and serum biotinidase activity.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2009, Volume: 13, Issue:5

    Topics: Alopecia; Anticonvulsants; Biotinidase; Child; Child, Preschool; Epilepsy; Female; Hair; Humans; Mal

2009
Effect of phenytoin and valproic acid therapy on serum lipid levels and liver function tests.
    Indian pediatrics, 2008, Volume: 45, Issue:10

    Topics: Anticonvulsants; Case-Control Studies; Child; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Epile

2008
Effect of a manually generated laboratory comment on requesting and performance of valproate assays.
    Journal of clinical pathology, 2008, Volume: 61, Issue:11

    Topics: Anticonvulsants; Drug Monitoring; Epilepsy; Humans; Unnecessary Procedures; Valproic Acid

2008
Thyroid hormones in children with epilepsy during long-term administration of carbamazepine and valproate.
    European journal of endocrinology, 2009, Volume: 160, Issue:1

    Topics: Anticonvulsants; Carbamazepine; Child; Drug Administration Schedule; Epilepsy; Female; Humans; Linea

2009
Valproate induced non hepatic hyperammonaemic encephalopathy (VNHE)--a study from tertiary care referral university hospital, north India.
    JPMA. The Journal of the Pakistan Medical Association, 2008, Volume: 58, Issue:11

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Hyperam

2008
The role of epilepsy in early language development in a child with a congenital lesion in the right hemisphere.
    Developmental medicine and child neurology, 2008, Volume: 50, Issue:11

    Topics: Anticonvulsants; Brain; Child; Cognition Disorders; Electroencephalography; Epilepsy; Functional Lat

2008
Body mass index and serum lipid changes during treatment with valproic acid in children with epilepsy.
    The Annals of pharmacotherapy, 2009, Volume: 43, Issue:1

    Topics: Age Factors; Blood Glucose; Body Mass Index; Child, Preschool; Cholesterol; Epilepsy; Female; Follow

2009
Population pharmacokinetics of valproate in Mexican children with epilepsy.
    Biopharmaceutics & drug disposition, 2008, Volume: 29, Issue:9

    Topics: Adolescent; Anticonvulsants; Body Weight; Child; Child, Preschool; Dose-Response Relationship, Drug;

2008
First-drug treatment failures in children newly diagnosed with epilepsy.
    Pediatric neurology, 2009, Volume: 40, Issue:2

    Topics: Adolescent; Age Factors; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female;

2009
Thrombophilic risk factors in epileptic children treated with valproic Acid.
    Pediatric neurology, 2009, Volume: 40, Issue:2

    Topics: Adolescent; Anticonvulsants; Antithrombin III; Blood Coagulation Factors; Child; Child, Preschool; E

2009
[Valproate treatment during pregnancy: description of four cases with foetal valproate syndrome].
    Ugeskrift for laeger, 2009, Jan-19, Volume: 171, Issue:4

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child; Child, Preschool; Developmental Disabilities; E

2009
Nonalcoholic fatty liver disease during valproate therapy.
    European journal of pediatrics, 2009, Volume: 168, Issue:11

    Topics: Anticonvulsants; Body Mass Index; Child; Epilepsy; Fatty Liver; Fatty Liver, Alcoholic; Female; Huma

2009
[Influence of the antagonist of adenosine A1 receptors, 8-cyclopentyl-1 ,3-dipropylxanthine, upon the anticonvulsant activity of antiepileptic drugs in mice].
    Przeglad lekarski, 2008, Volume: 65, Issue:11

    Topics: Adenosine A1 Receptor Antagonists; Animals; Anticonvulsants; Brain; Drug Interactions; Epilepsy; Mal

2008
Bone metabolism alteration on antiepileptic drug therapy.
    Indian journal of pediatrics, 2009, Volume: 76, Issue:4

    Topics: Alkaline Phosphatase; Anticonvulsants; Bone and Bones; Carbamazepine; Child; Child, Preschool; Epile

2009
[Meropenem and valproic acid. An interaction to remember].
    Anales de pediatria (Barcelona, Spain : 2003), 2009, Volume: 70, Issue:2

    Topics: Anti-Bacterial Agents; Anticonvulsants; Drug Interactions; Epilepsy; Female; Humans; Infant; Meropen

2009
Pharmacokinetic modeling of carbamazepine based on clinical data from Serbian epileptic patients.
    Methods and findings in experimental and clinical pharmacology, 2008, Volume: 30, Issue:9

    Topics: Adult; Age Factors; Algorithms; Anticonvulsants; Biological Availability; Carbamazepine; Child; Data

2008
Long-term effects of valproic acid on reproductive endocrine functions in Turkish women with epilepsy.
    Gynecologic and obstetric investigation, 2009, Volume: 67, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Hype

2009
Weight gain in children treated with valproate.
    Journal of child neurology, 2009, Volume: 24, Issue:3

    Topics: Adolescent; Anticonvulsants; Body Mass Index; Child; Child, Preschool; Epilepsy; Female; Humans; Lon

2009
Effects of epilepsy and valproic acid on oxidant status in children with idiopathic epilepsy.
    Epilepsy research, 2009, Volume: 84, Issue:2-3

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Erythrocytes; Female; Glutathione Pe

2009
Commentary to: "Evaluation of serum lipids and carotid artery intima media thickness in epileptic children treated with valproic acid".
    Brain & development, 2009, Volume: 31, Issue:6

    Topics: Age Factors; Anticonvulsants; Carotid Stenosis; Child; Endothelial Cells; Epilepsy; Folic Acid; Homo

2009
Valproate and lamotrigine level variation with menstrual cycle phase and oral contraceptive use.
    Neurology, 2009, Mar-10, Volume: 72, Issue:10

    Topics: Adolescent; Adult; Anticonvulsants; Body Mass Index; Contraceptives, Oral, Combined; Drug Interactio

2009
Drug treatment of epilepsy in the century of the ILAE: the second 50 years, 1959-2009.
    Epilepsia, 2009, Volume: 50 Suppl 3

    Topics: Advertising; Anticonvulsants; Epilepsy; History, 20th Century; History, 21st Century; Humans; Nation

2009
Changing trends in antiepileptic drug prescribing in girls of child-bearing potential.
    Archives of disease in childhood, 2009, Volume: 94, Issue:6

    Topics: Abnormalities, Drug-Induced; Adolescent; Anticonvulsants; Carbamazepine; Child; Contraceptive Agents

2009
[When a seizure occurs...].
    Revue medicale de Liege, 2009, Volume: 64, Issue:1

    Topics: Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Fructose; Humans

2009
[Cognitive impairment and parkinsonism due to use of sodium valproate].
    Tijdschrift voor gerontologie en geriatrie, 2009, Volume: 40, Issue:1

    Topics: Aged; Anticonvulsants; Cognition Disorders; Epilepsy; Humans; Male; Parkinson Disease, Secondary; Re

2009
An experimental design for finding of minimum dosage of carbamazepine and valproate in preventing of seizure attacks.
    Pakistan journal of pharmaceutical sciences, 2009, Volume: 22, Issue:2

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Dose-Response Relationship, Drug; Drug Dosage Cal

2009
Valproic acid delayed release (Stavzor).
    The Medical letter on drugs and therapeutics, 2009, Apr-06, Volume: 51, Issue:1309

    Topics: Anticonvulsants; Capsules; Chemistry, Pharmaceutical; Delayed-Action Preparations; Epilepsy; Humans;

2009
Interaction of tiagabine with valproate in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves.
    Advances in medical sciences, 2009, Volume: 54, Issue:1

    Topics: Animals; Anticonvulsants; Brain Chemistry; Convulsants; Dose-Response Relationship, Drug; Drug Inter

2009
Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs.
    The New England journal of medicine, 2009, Apr-16, Volume: 360, Issue:16

    Topics: Adult; Anticonvulsants; Carbamazepine; Child, Preschool; Cognition; Developmental Disabilities; Dose

2009
A novel system allowing long-term simultaneous video-electroencephalography recording, drug infusion and blood sampling in rats.
    Journal of neuroscience methods, 2009, May-15, Volume: 179, Issue:2

    Topics: Animals; Anticonvulsants; Blood Specimen Collection; Catheterization; Disease Models, Animal; Drug D

2009
Epilepsy in Angelman syndrome: a questionnaire-based assessment of the natural history and current treatment options.
    Epilepsia, 2009, Volume: 50, Issue:11

    Topics: Adolescent; Adult; Angelman Syndrome; Anticonvulsants; Child; Child, Preschool; Clonazepam; Comorbid

2009
Valproate-associated coagulopathies in children during short-term treatment.
    Journal of child neurology, 2009, Volume: 24, Issue:12

    Topics: Adolescent; Anticonvulsants; Biomarkers; Blood Coagulation Disorders; Blood Coagulation Factors; Blo

2009
Pregnancy, delivery, and outcome for the child in maternal epilepsy.
    Epilepsia, 2009, Volume: 50, Issue:9

    Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Apgar Score; Birth Weight; Congenital Abnormali

2009
[Fetal malformations in women with epilepsy].
    Akusherstvo i ginekologiia, 2009, Volume: 48, Issue:1

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Bulgaria; Carbamazepine; Epilepsy; Female; Humans; Inf

2009
Effectiveness of the first antiepileptic drug in the treatment of pediatric epilepsy.
    Pediatric neurology, 2009, Volume: 41, Issue:1

    Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Fructose; Humans; Retrospective S

2009
Stupor and fast activity on electroencephalography in a child treated with valproate.
    Pediatric neurology, 2009, Volume: 41, Issue:1

    Topics: Brain; Child, Preschool; Electroencephalography; Epilepsy; Female; GABA Agents; Humans; Stupor; Valp

2009
Which is the best anti-convulsant drug for the treatment of epilepsy in psoriatic or other Th1 mediated skin disease patients?
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 2009, Volume: 144, Issue:3

    Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Interleukin-2; NF-kappa B; Psoriasis; Th1 Cells; T

2009
A cocaine body packer case report: clinical and forensic aspects.
    Clinical toxicology (Philadelphia, Pa.), 2009, Volume: 47, Issue:6

    Topics: Anticonvulsants; Cocaine; Crime; Digestive System; Epilepsy; Fatal Outcome; Foreign Bodies; Forensic

2009
Poor applicability of estimation method for adults to calculate unbound serum concentrations of valproic acid in epileptic neonates and infants.
    Journal of clinical pharmacy and therapeutics, 2009, Volume: 34, Issue:4

    Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Child, Preschool; Drug Monitoring; Epilepsy;

2009
Ring chromosome 20 syndrome: a link between epilepsy onset and neuropsychological impairment in three children.
    Epilepsia, 2009, Volume: 50, Issue:11

    Topics: Adult; Age of Onset; Anticonvulsants; Child; Chromosomes, Human, Pair 20; Cognition Disorders; Comor

2009
Isobolographic characterization of interactions of levetiracetam with the various antiepileptic drugs in the mouse 6 Hz psychomotor seizure model.
    Epilepsy research, 2009, Volume: 86, Issue:2-3

    Topics: Animals; Anticonvulsants; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug

2009
A case of fetal valproate syndrome with new features expanding the phenotype.
    Saudi medical journal, 2009, Volume: 30, Issue:7

    Topics: Abnormalities, Multiple; Anticonvulsants; Epilepsy; Female; Fetus; Humans; Infant; Phenotype; Pregna

2009
Acute pancreatitis associated to the use of valproic acid.
    Arquivos de neuro-psiquiatria, 2009, Volume: 67, Issue:2B

    Topics: Acute Disease; Child; Epilepsy; Female; Humans; Pancreatitis; Valproic Acid

2009
Once daily monotherapy with prolonged-release valproate minitablets given in the evening--a chronopharmacological study.
    International journal of clinical pharmacology and therapeutics, 2009, Volume: 47, Issue:7

    Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Chronobiology Phenomena; Delayed-Action Prepa

2009
Na VPA-induced acute ischemic stroke in an epileptic patient with methylenetetrahydrofolate reductase gene polymorphism.
    Epilepsy research, 2009, Volume: 86, Issue:2-3

    Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Brain; Brain Ischemia; Epilepsy; Humans; Hyperhomo

2009
Cognitive function after fetal exposure to antiepileptic drugs.
    The New England journal of medicine, 2009, Aug-06, Volume: 361, Issue:6

    Topics: Anticonvulsants; Child, Preschool; Confounding Factors, Epidemiologic; Developmental Disabilities; E

2009
Improved seizure control by alternating therapy of levetiracetam and valproate in epileptic rats.
    Epilepsia, 2010, Volume: 51, Issue:3

    Topics: Animals; Anticonvulsants; Dentate Gyrus; Disease Models, Animal; Drug Administration Schedule; Drug

2010
The metabolic syndrome in overweight epileptic patients treated with valproic acid.
    Epilepsia, 2010, Volume: 51, Issue:2

    Topics: Adolescent; Anticonvulsants; Body Mass Index; Cardiovascular Diseases; Child; Comorbidity; Dyslipide

2010
A 12-month longitudinal study of calcium metabolism and bone turnover during valproate monotherapy.
    European journal of neurology, 2010, Volume: 17, Issue:2

    Topics: Adolescent; Anticonvulsants; Bone and Bones; Calcium; Case-Control Studies; Diet; Epilepsy; Exercise

2010
Nitric oxide, lipid peroxidation, and antioxidant enzyme levels in epileptic children using valproic acid.
    Brain research, 2009, Nov-10, Volume: 1297

    Topics: Anticonvulsants; Antioxidants; Biomarkers; Catalase; Child; Child, Preschool; Enzyme Assays; Enzymes

2009
Chronic antiepileptic monotherapy, bone metabolism, and body composition in non-institutionalized children.
    Developmental medicine and child neurology, 2010, Volume: 52, Issue:3

    Topics: Anthropometry; Anticonvulsants; Body Composition; Body Height; Body Mass Index; Body Weight; Carbama

2010
Is asymmetric dimethylarginine responsible for the vascular events in patients under antiepileptic drug treatment?
    Epilepsy research, 2009, Volume: 87, Issue:1

    Topics: Adult; Anticonvulsants; Arginine; Arterial Occlusive Diseases; Carbamazepine; Drug Monitoring; Epile

2009
Effects of CYP2C19 and CYP2C9 genotypes on pharmacokinetic variability of valproic acid in Chinese epileptic patients: nonlinear mixed-effect modeling.
    European journal of clinical pharmacology, 2009, Volume: 65, Issue:12

    Topics: Adult; Aged; Antimanic Agents; Aryl Hydrocarbon Hydroxylases; China; Cytochrome P-450 CYP2C19; Cytoc

2009
Ghrelin levels are reduced in prepubertal epileptic children under treatment with carbamazepine or valproic acid.
    Epilepsia, 2010, Volume: 51, Issue:2

    Topics: Age Factors; Anticonvulsants; Body Height; Body Mass Index; Carbamazepine; Child; Depression, Chemic

2010
Introduction of intravenous formulations of the antiepileptic drugs levetiracetam and valproate to the Australian market.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2009, Volume: 16, Issue:12

    Topics: Anticonvulsants; Australia; Epilepsy; Humans; Injections, Intravenous; Marketing of Health Services;

2009
Unilateral lung agenesis: coincidence or association with maternal valproate therapy?
    Journal of paediatrics and child health, 2009, Volume: 45, Issue:10

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Lung; Male;

2009
Once-daily dosing is appropriate for extended-release divalproex over a wide dose range, but not for enteric-coated, delayed-release divalproex: evidence via computer simulations and implications for epilepsy therapy.
    Epilepsy research, 2009, Volume: 87, Issue:2-3

    Topics: Anticonvulsants; Area Under Curve; Computer Simulation; Delayed-Action Preparations; Dose-Response R

2009
A prospective study of cognitive fluency and originality in children exposed in utero to carbamazepine, lamotrigine, or valproate monotherapy.
    Epilepsy & behavior : E&B, 2009, Volume: 16, Issue:4

    Topics: Analysis of Variance; Anticonvulsants; Carbamazepine; Child, Preschool; Cognition; Creativity; Epile

2009
Metabolic alterations during valproic acid treatment: a prospective study.
    Pediatric neurology, 2009, Volume: 41, Issue:6

    Topics: Adolescent; Androgens; Anticonvulsants; Blood Glucose; Body Mass Index; Child; Child, Preschool; Cho

2009
Effect of pharmacist participation in the health care team on therapeutic drug monitoring utilization for antiepileptic drugs.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2009, Volume: 92, Issue:11

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Chi-Square Distribution;

2009
Syndrome of inappropriate antidiuretic hormone secretion (SIADH) or hyponatraemia associated with valproic Acid: four case reports from the Netherlands and a case/non-case analysis of vigibase.
    Drug safety, 2010, Jan-01, Volume: 33, Issue:1

    Topics: Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Anticonvulsants; Databases, Factua

2010
Analytical interference of carbamazepine on the Abbott TDx and Abbott Axsym tricyclic antidepressant assays.
    Pathology, 2009, Volume: 41, Issue:7

    Topics: Adult; Anticonvulsants; Antidepressive Agents, Tricyclic; Carbamazepine; Cross Reactions; Drug Monit

2009
Inhibition of long-term potentiation by valproic acid through modulation of cyclic AMP.
    Epilepsia, 2010, Volume: 51, Issue:8

    Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Cyclic AMP; Cyclic AMP-Dependent Protein Kina

2010
[Effects of valproate on male reproductive functions].
    Turk psikiyatri dergisi = Turkish journal of psychiatry, 2009,Winter, Volume: 20, Issue:4

    Topics: Anticonvulsants; Antimanic Agents; Epilepsy; Female; Genitalia, Male; Humans; Male; Menstrual Cycle;

2009
Changing patterns of antiepileptic drug use in pregnant Australian women.
    Acta neurologica Scandinavica, 2010, Volume: 121, Issue:2

    Topics: Anticonvulsants; Australia; Congenital Abnormalities; Epilepsy; Female; Humans; Linear Models; Pract

2010
Effects of levetiracetam and valproic acid monotherapy on sex-steroid hormones in prepubertal children--results from a pilot study.
    Epilepsy research, 2010, Volume: 88, Issue:2-3

    Topics: Analysis of Variance; Anticonvulsants; Child; Cohort Studies; Cross-Sectional Studies; Epilepsy; Fem

2010
Valproic acid: long-term effects on children exposed in utero.
    Prescrire international, 2009, Volume: 18, Issue:104

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Cohort Studies; Contraindications; Dose

2009
Adverse effects of carbamazepine, phenytoin, valproate and lamotrigine monotherapy in epileptic adult Chinese patients.
    Clinical neurology and neurosurgery, 2010, Volume: 112, Issue:4

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; China; Drug Eruptions; Epilepsy; Female; Hu

2010
Effects of the antiepileptic drugs on peripheral nerve function.
    Acta neurologica Scandinavica, 2010, Volume: 121, Issue:1

    Topics: Anticonvulsants; Carbamazepine; Epilepsy; Female; Fructose; Humans; Male; Median Nerve; Neural Condu

2010
Hippocampal synaptic plasticity, memory, and epilepsy: effects of long-term valproic acid treatment.
    Biological psychiatry, 2010, Mar-15, Volume: 67, Issue:6

    Topics: Animals; Anticonvulsants; Behavior, Animal; Biophysics; Calcium-Calmodulin-Dependent Protein Kinase

2010
Levetiracetam inhibits interleukin-1 beta inflammatory responses in the hippocampus and piriform cortex of epileptic rats.
    Neuroscience letters, 2010, Mar-03, Volume: 471, Issue:2

    Topics: Animals; Anticonvulsants; Astrocytes; Chronic Disease; Epilepsy; Gliosis; Hippocampus; Interleukin-1

2010
The influence of cytochrome oxidase CYP2A6, CYP2B6, and CYP2C9 polymorphisms on the plasma concentrations of valproic acid in epileptic patients.
    Clinical neurology and neurosurgery, 2010, Volume: 112, Issue:4

    Topics: Adolescent; Adult; Alleles; Aryl Hydrocarbon Hydroxylases; Child; Child, Preschool; China; Cytochrom

2010
POLG DNA testing as an emerging standard of care before instituting valproic acid therapy for pediatric seizure disorders.
    Seizure, 2010, Volume: 19, Issue:3

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diffuse Cerebral Sclerosis of Schilder; DNA Mu

2010
Valproate-induced hyperammonemic encephalopathy, rapidly improved by i.v. carnitine and glucose/thiamine.
    Scandinavian journal of gastroenterology, 2010, Volume: 45, Issue:6

    Topics: Aged; Ammonia; Anticonvulsants; Brain Diseases, Metabolic; Carnitine; Dose-Response Relationship, Dr

2010
Quantitative analysis of motor performance in epilepsy patients treated with valproate.
    Seizure, 2010, Volume: 19, Issue:3

    Topics: Adult; Aged; Anticonvulsants; Epilepsy; Female; Humans; Male; Middle Aged; Motor Skills; Reaction Ti

2010
Long-term efficacy of valproate versus lamotrigine in treatment of idiopathic generalized epilepsies in children and adolescents.
    Seizure, 2010, Volume: 19, Issue:3

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Lamotrigine; Male; T

2010
TrkB/BDNF-dependent striatal plasticity and behavior in a genetic model of epilepsy: modulation by valproic acid.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010, Volume: 35, Issue:7

    Topics: Analysis of Variance; Animals; Anticonvulsants; Avoidance Learning; Brain-Derived Neurotrophic Facto

2010
Valproic acid in the complex therapy of malignant tumors.
    Current drug targets, 2010, Volume: 11, Issue:3

    Topics: Acetylation; Angiogenesis Inhibitors; Apoptosis; Azacitidine; Cell Cycle; Clinical Trials as Topic;

2010
Growth hormone levels in children and adolescents with epilepsy.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2010, Volume: 14, Issue:6

    Topics: Adolescent; Anthropometry; Body Weight; Carbamazepine; Chi-Square Distribution; Child; Developmental

2010
Fanconi syndrome caused by valproic acid.
    Pediatric neurology, 2010, Volume: 42, Issue:4

    Topics: Adolescent; Anticonvulsants; Child; Epilepsy; Fanconi Syndrome; Female; Humans; Male; Time Factors;

2010
Valproic acid-induced pancreatitis in an adult.
    Arquivos de neuro-psiquiatria, 2010, Volume: 68, Issue:1

    Topics: Adult; Anticonvulsants; Epilepsy; Humans; Male; Pancreatitis; Valproic Acid

2010
Antiepileptic drugs modify power of high EEG frequencies and their neural generators.
    European journal of neurology, 2010, Volume: 17, Issue:10

    Topics: Adolescent; Adult; Anticonvulsants; Brain Waves; Carbamazepine; Electroencephalography; Epilepsy; Fe

2010
Absence of a general association between ABCB1 genetic variants and response to antiepileptic drugs in epilepsy patients.
    Biochimie, 2010, Volume: 92, Issue:9

    Topics: Adolescent; Adult; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Casse

2010
Late-onset nocturnal intractable seizure during sleep: what is the origin?
    Medicina (Kaunas, Lithuania), 2010, Volume: 46, Issue:2

    Topics: Anticonvulsants; Clonazepam; Epilepsy; Follow-Up Studies; Humans; Male; Middle Aged; Polysomnography

2010
Pharmacokinetics and clinical application of intravenous valproate in Thai epileptic children.
    Brain & development, 2011, Volume: 33, Issue:3

    Topics: Adolescent; Ammonia; Anticonvulsants; Child; Child, Preschool; Cross-Sectional Studies; Epilepsy; Fe

2011
Effect of CPS14217C>A genotype on valproic-acid-induced hyperammonemia.
    Pediatrics international : official journal of the Japan Pediatric Society, 2010, Volume: 52, Issue:5

    Topics: Adolescent; Adult; Age Distribution; Analysis of Variance; Anticonvulsants; Carbamoyl-Phosphate Synt

2010
Modification in body weight associated with antiepileptic drugs.
    Arquivos de neuro-psiquiatria, 2010, Volume: 68, Issue:2

    Topics: Adult; Anticonvulsants; Body Mass Index; Carbamazepine; Epilepsy; Female; Humans; Male; Valproic Aci

2010
[Pathogenetic basis of pharmaceutical hepatitis induced by depakine in children].
    Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, 2009, Issue:8

    Topics: Anticonvulsants; Biliary Dyskinesia; Case-Control Studies; Chemical and Drug Induced Liver Injury; C

2009
Gastaut type-idiopathic childhood occipital epilepsy and childhood absence epilepsy: a clinically significant association?
    Seizure, 2010, Volume: 19, Issue:6

    Topics: Anticonvulsants; Blindness; Child; Electroencephalography; Epilepsy; Epilepsy, Absence; Ethosuximide

2010
[Characteristics of the children with epilepsy followed in the Marrakech University Hospital].
    Revue neurologique, 2010, Volume: 166, Issue:11

    Topics: Adolescent; Age of Onset; Anticonvulsants; Cerebral Palsy; Child; Child, Preschool; Consanguinity; E

2010
BsmI vitamin D receptor's polymorphism and bone mineral density in men and premenopausal women on long-term antiepileptic therapy.
    European journal of neurology, 2011, Volume: 18, Issue:1

    Topics: Absorptiometry, Photon; Adolescent; Adult; Alleles; Anticonvulsants; Bone Density; Calcium, Dietary;

2011
Valproate and risk of fracture in Rett syndrome.
    Archives of disease in childhood, 2010, Volume: 95, Issue:6

    Topics: Adolescent; Adult; Anticonvulsants; Australia; Child; Child, Preschool; Drug Administration Schedule

2010
Role of parental risk factors in the aetiology of isolated non-syndromic metopic craniosynostosis.
    The British journal of oral & maxillofacial surgery, 2010, Volume: 48, Issue:6

    Topics: Anticonvulsants; Chi-Square Distribution; Craniosynostoses; Epilepsy; Female; Fertility Agents, Fema

2010
Characterization, using comparative proteomics, of differentially expressed proteins in the hippocampus of the mesial temporal lobe of epileptic rats following treatment with valproate.
    Amino acids, 2011, Volume: 40, Issue:1

    Topics: Adolescent; Adult; Animals; Child; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Ep

2011
[Effect of UGTIA6 A541G genetic polymorphism on the metabolism of valproic acid in Han epileptic children from Henan].
    Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2010, Volume: 12, Issue:6

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; China; Epilepsy; Glucuronosyltransferase; Huma

2010
[Changes of body mass index and plasma galanin in children with epilepsy following valproate sodium treatment].
    Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2010, Volume: 12, Issue:6

    Topics: Adolescent; Anticonvulsants; Body Mass Index; Child; Child, Preschool; Epilepsy; Female; Galanin; Hu

2010
Effects of valproate and carbamazepine monotherapy on neuroactive steroids, their precursors and metabolites in adult men with epilepsy.
    The Journal of steroid biochemistry and molecular biology, 2010, Volume: 122, Issue:4

    Topics: Adult; Androstanes; Anticonvulsants; Carbamazepine; Epilepsy; Gas Chromatography-Mass Spectrometry;

2010
Effect of valproic acid treatment on copper availability in adult epileptic patients.
    Clinical biochemistry, 2010, Volume: 43, Issue:13-14

    Topics: Adult; Anticonvulsants; Case-Control Studies; Ceruloplasmin; Copper; Epilepsy; Humans; Valproic Acid

2010
Valproate-induced reversible hemichorea.
    Movement disorders : official journal of the Movement Disorder Society, 2010, Jul-30, Volume: 25, Issue:10

    Topics: Anticonvulsants; Brain; Chorea; Epilepsy; Functional Laterality; Humans; Magnetic Resonance Imaging;

2010
Early cognitive development in children born to women with epilepsy: a prospective report.
    Epilepsia, 2010, Volume: 51, Issue:10

    Topics: Age Factors; Anticonvulsants; Child; Child of Impaired Parents; Cognition; Cognition Disorders; Deve

2010
Quality of life and treatment satisfaction in Spanish epilepsy patients on monotherapy with lamotrigine or valproic acid.
    Seizure, 2010, Volume: 19, Issue:7

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Lamotrigine; Male; Patient Satisfaction; Quality o

2010
Retrospective analysis of the effectiveness of first-line antiepileptic drugs for generalized onset and unclassified epileptic seizures in Chinese children.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2011, Volume: 27, Issue:2

    Topics: Age of Onset; Anticonvulsants; Asian People; Carbamazepine; Child; Child, Preschool; Epilepsy; Femal

2011
Effects of AEDs on biomarkers in people with epilepsy: CRP, HbA1c and eGFR.
    Epilepsy research, 2010, Volume: 91, Issue:2-3

    Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Biomarkers; C-Reactive Protein; Epilepsy; Female; G

2010
Comparative pharmacodynamic and pharmacokinetic analysis of two anticonvulsant halo derivatives of 2,2,3,3-tetramethylcyclopropanecarboxamide, an amide of a cyclic analog of valproic acid.
    Epilepsia, 2010, Volume: 51, Issue:10

    Topics: Abnormalities, Drug-Induced; Amides; Analgesics; Animals; Anticonvulsants; Cyclopropanes; Disease Mo

2010
Is lamotrigine a significant human teratogen? Observations from the Australian Pregnancy Register.
    Seizure, 2010, Volume: 19, Issue:9

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Australia; Congenital Abnormalities; Dose-Response Rel

2010
Drug treatment failures and effectivity in children with newly diagnosed epilepsy.
    Seizure, 2010, Volume: 19, Issue:9

    Topics: Adolescent; Age of Onset; Anticonvulsants; Carbamazepine; Chi-Square Distribution; Child; Child, Pre

2010
[Effect of Chaihu Shugan Tang on excitability in different brain regions of pentylenetetrazole-kindled chronic epileptic rats].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2010, Volume: 35, Issue:12

    Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Aspartic Acid; Brain; Chronic Disease; Deoxyglucose; Disease

2010
Correlation between EEG abnormalities and symptoms of autism spectrum disorder (ASD).
    Brain & development, 2010, Volume: 32, Issue:10

    Topics: Adolescent; Age of Onset; Aging; Anticonvulsants; Asperger Syndrome; Autistic Disorder; Brain Mappin

2010
Age and comedications influence levetiracetam pharmacokinetics in children.
    Pediatric neurology, 2010, Volume: 43, Issue:4

    Topics: Adolescent; Age Factors; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Interactions;

2010
Blood ammonia levels in epileptic children on 2 dose ranges of valproic acid monotherapy: a cross-sectional study.
    Journal of child neurology, 2011, Volume: 26, Issue:1

    Topics: Ammonia; Anticonvulsants; Child; Child, Preschool; Cross-Sectional Studies; Epilepsy; Fluorescence P

2011
Oxidative stress in children affected by epileptic encephalopathies.
    Journal of the neurological sciences, 2011, Jan-15, Volume: 300, Issue:1-2

    Topics: Biomarkers; Blood Proteins; Child; Child, Preschool; Epilepsy; F2-Isoprostanes; Female; Humans; Infa

2011
A 6-month prospective study on efficacy safety and QOL profiles of extended-release formulation of valproate in patients with epilepsy.
    Seizure, 2011, Volume: 20, Issue:1

    Topics: Adolescent; Adult; Aged; Chemistry, Pharmaceutical; Child; Delayed-Action Preparations; Epilepsy; Fe

2011
Transplacental genotoxicity of antiepileptic drugs: animal model and pilot study on mother/newborn cohort.
    Reproductive toxicology (Elmsford, N.Y.), 2010, Volume: 30, Issue:4

    Topics: Adult; Animals; Animals, Newborn; Anticonvulsants; Cohort Studies; Epilepsy; Female; Humans; Infant,

2010
Drug-to-drug interaction between sodium valproate and trihexyphenidyl in a child with extrapyramidal cerebral palsy and epilepsy.
    European journal of clinical pharmacology, 2011, Volume: 67, Issue:3

    Topics: Anticonvulsants; Cerebral Palsy; Child, Preschool; Dose-Response Relationship, Drug; Drug Interactio

2011
Factors influencing valproate pharmacokinetics in children and adults.
    International journal of clinical pharmacology and therapeutics, 2010, Volume: 48, Issue:11

    Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Body Weight; Carbamazepine; Child; Child, Pre

2010
Circulating levels of allopregnanolone, a neuroactive steroid, and leptin during treatment with valproic acid in children with epilepsy.
    Neuroendocrinology, 2011, Volume: 93, Issue:3

    Topics: Anticonvulsants; Child; Epilepsy; Female; Humans; Immunoassay; Leptin; Male; Obesity; Pregnanolone;

2011
Predictability of individualized dosage regimens of carbamazepine and valproate mono- and combination therapy.
    Journal of clinical pharmacy and therapeutics, 2011, Volume: 36, Issue:5

    Topics: Adult; Aged; Anticonvulsants; Bayes Theorem; Carbamazepine; Chronic Disease; Databases, Factual; Dem

2011
[Epileptic spasms without hypsarrhythmia. A new case report and review of the literature].
    Revista de neurologia, 2010, Nov-16, Volume: 51, Issue:10

    Topics: Anticonvulsants; Diagnosis, Differential; Electroencephalography; Epilepsy; Female; Humans; Infant;

2010
Valproic acid and phenobarbital blood levels during the first month of treatment with the ketogenic diet.
    Acta neurologica Scandinavica, 2010, Volume: 122, Issue:4

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Combined Modality Therapy; Diet, Ketogenic; Ep

2010
The Australian brain and cognition and antiepileptic drugs study: IQ in school-aged children exposed to sodium valproate and polytherapy.
    Journal of the International Neuropsychological Society : JINS, 2011, Volume: 17, Issue:1

    Topics: Anticonvulsants; Australia; Brain; Child; Cognition; Comprehension; Drug Therapy, Combination; Epile

2011
Fluctuating and constant valproate administration gives equivalent seizure control in rats with genetic and acquired epilepsy.
    Seizure, 2011, Volume: 20, Issue:1

    Topics: Animals; Epilepsy; Epilepsy, Absence; Female; Infusion Pumps; Male; Rats; Rats, Mutant Strains; Valp

2011
Effects of breastfeeding in children of women taking antiepileptic drugs.
    Neurology, 2010, Nov-30, Volume: 75, Issue:22

    Topics: Adult; Anticonvulsants; Breast Feeding; Carbamazepine; Child, Preschool; Cognition; Epilepsy; Female

2010
Serum asymmetric dimethylarginine (ADMA), homocysteine, vitamin B(12), folate levels, and lipid profiles in epileptic children treated with valproic acid.
    European journal of pediatrics, 2011, Volume: 170, Issue:7

    Topics: Adolescent; Anticonvulsants; Arginine; Biomarkers; Case-Control Studies; Child; Child, Preschool; Ch

2011
Valproic acid-associated acute liver failure in children: case report and analysis of liver transplantation outcomes in the United States.
    The Journal of pediatrics, 2011, Volume: 158, Issue:5

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Follow-Up Studies; Humans; I

2011
A preliminary investigation on the possible association between diminished copper availability and non-alcoholic fatty liver disease in epileptic patients treated with valproic acid.
    Upsala journal of medical sciences, 2011, Volume: 116, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Biological Availability; Copper; Epilep

2011
Evaluation of valproate effects on acylcarnitine in epileptic children by LC-MS/MS.
    Brain & development, 2011, Volume: 33, Issue:10

    Topics: Adolescent; Anticonvulsants; Carnitine; Child; Child, Preschool; Chromatography, Liquid; Epilepsy; F

2011
Empirical approach for improved estimation of unbound serum concentrations of valproic acid in epileptic infants by considering their physical development.
    Biological & pharmaceutical bulletin, 2011, Volume: 34, Issue:1

    Topics: Anticonvulsants; Drug Monitoring; Epilepsy; Female; Humans; Infant; Infant, Newborn; Male; Nonlinear

2011
The effect of lamotrigine on valproic acid concentrations.
    Current drug safety, 2011, Feb-01, Volume: 6, Issue:1

    Topics: Adolescent; Child; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Epilepsy; Female; H

2011
Thinking beyond the obvious: hepatotoxicity secondary to idiosyncratic depakote toxicity.
    American journal of therapeutics, 2012, Volume: 19, Issue:6

    Topics: Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Monitoring; Epilepsy; Female; H

2012
Study of epileptiform activity in cerebral ganglion of mud crab Scylla serrata.
    Invertebrate neuroscience : IN, 2011, Volume: 11, Issue:1

    Topics: Animals; Anticonvulsants; Brachyura; Convulsants; Disease Models, Animal; Epilepsy; gamma-Aminobutyr

2011
Valproate attenuates the risk of myocardial infarction in patients with epilepsy: a nationwide cohort study.
    Pharmacoepidemiology and drug safety, 2011, Volume: 20, Issue:2

    Topics: Adult; Aged; Anticonvulsants; Case-Control Studies; Cause of Death; Chi-Square Distribution; Cohort

2011
Nonalcoholic fatty liver disease in adolescents receiving valproic acid.
    Epilepsy & behavior : E&B, 2011, Volume: 20, Issue:2

    Topics: Adolescent; Alanine Transaminase; Anticonvulsants; Blood Pressure; Body Weight; Chemical and Drug In

2011
Child development following in utero exposure: levetiracetam vs sodium valproate.
    Neurology, 2011, Jan-25, Volume: 76, Issue:4

    Topics: Anticonvulsants; Child Development; Child, Preschool; Cognition; Epilepsy; Female; Humans; Infant; L

2011
Neonatal episodic hypoglycemia: a finding of valproic acid withdrawal.
    Journal of clinical research in pediatric endocrinology, 2010, Volume: 2, Issue:2

    Topics: Anticonvulsants; Epilepsy; Female; Glucose; Humans; Hypoglycemia; Infant, Newborn; Infant, Newborn,

2010
Lack of association of ABCB1 and PXR polymorphisms with response to treatment in epilepsy.
    Seizure, 2011, Volume: 20, Issue:5

    Topics: Adolescent; Adult; Anticonvulsants; Asian People; ATP Binding Cassette Transporter, Subfamily B; ATP

2011
Valproic acid modulates superoxide dismutase, uric acid-independent FRAP and zinc in blood of adult epileptic patients.
    Biological trace element research, 2011, Volume: 143, Issue:3

    Topics: Adult; Epilepsy; Female; Ferric Compounds; Humans; Male; Oxidation-Reduction; Superoxide Dismutase;

2011
Real-time, in vivo monitoring and pharmacokinetics of valproic acid via a novel biomarker in exhaled breath.
    Chemical communications (Cambridge, England), 2011, May-07, Volume: 47, Issue:17

    Topics: Biomarkers; Breath Tests; Epilepsy; Exhalation; Humans; Monitoring, Physiologic; Protein Binding; Sp

2011
Association between ABCB1 polymorphism and response to sodium valproate treatment in Malaysian epilepsy patients.
    Epileptic disorders : international epilepsy journal with videotape, 2011, Volume: 13, Issue:1

    Topics: Adult; Alleles; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette

2011
Neurodevelopment of children exposed in utero to lamotrigine, sodium valproate and carbamazepine.
    Archives of disease in childhood, 2011, Volume: 96, Issue:7

    Topics: Anticonvulsants; Carbamazepine; Case-Control Studies; Child, Preschool; Developmental Disabilities;

2011
Increase in non-transferrin bound iron and the oxidative stress status in epilepsy patients treated using valproic acid monotherapy.
    International journal of clinical pharmacology and therapeutics, 2011, Volume: 49, Issue:4

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Iron; Lipid Peroxidation; Male; Oxidative Stress;

2011
[Staring episodes in children with developmental disorders: epilepsy or behaviour?].
    Nederlands tijdschrift voor geneeskunde, 2011, Volume: 155

    Topics: Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Child; Child Behavior; Diagnosis,

2011
Folie à deux: double case-report of shared delusions with a fatal outcome.
    La Clinica terapeutica, 2011, Volume: 162, Issue:1

    Topics: Adult; Anticonvulsants; Antipsychotic Agents; Benzodiazepines; Clozapine; Combined Modality Therapy;

2011
Drug-resistant epilepsia and fulminant valproate liver toxicity. Alpers-Huttenlocher syndrome in two children confirmed post mortem by identification of p.W748S mutation in POLG gene.
    Medical science monitor : international medical journal of experimental and clinical research, 2011, Volume: 17, Issue:4

    Topics: Amino Acid Substitution; Child; Diffuse Cerebral Sclerosis of Schilder; DNA Polymerase gamma; DNA-Di

2011
The effect of valproate therapy on thrombin generation determined by calibrated automated thrombography.
    Klinische Padiatrie, 2011, Volume: 223, Issue:3

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Female; F

2011
Lack of association of ABCB1 haplotypes on five loci with response to treatment in epilepsy.
    Seizure, 2011, Volume: 20, Issue:7

    Topics: Alleles; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transp

2011
The relationship between UGT1A4 polymorphism and serum concentration of lamotrigine in patients with epilepsy.
    Epilepsy research, 2011, Volume: 95, Issue:1-2

    Topics: Adult; Amino Acid Substitution; Anticonvulsants; Chromatography, High Pressure Liquid; Dose-Response

2011
No effect of co-administered antiepileptic drugs on in-vivo protein binding parameters of valproic acid in patients with epilepsy.
    The Journal of pharmacy and pharmacology, 2011, Volume: 63, Issue:7

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Fe

2011
Pharmacokinetic and pharmacodynamic interactions of valproate, phenytoin, phenobarbitone and carbamazepine with curcumin in experimental models of epilepsy in rats.
    Pharmacology, biochemistry, and behavior, 2011, Volume: 99, Issue:3

    Topics: Animals; Anticonvulsants; Carbamazepine; Curcumin; Disease Models, Animal; Drug Interactions; Drug T

2011
Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry.
    The Lancet. Neurology, 2011, Volume: 10, Issue:7

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epile

2011
Serum insulin, cortisol, leptin, neuropeptide Y, galanin and ghrelin levels in epileptic children receiving valproate.
    Hormone research in paediatrics, 2011, Volume: 76, Issue:1

    Topics: Adolescent; Child; Child, Preschool; Epilepsy; Galanin; Ghrelin; Humans; Hydrocortisone; Insulin; Le

2011
Novel characterization of drug-associated pancreatitis in children.
    Journal of pediatric gastroenterology and nutrition, 2011, Volume: 53, Issue:4

    Topics: Acute Disease; Adolescent; Adrenal Cortex Hormones; Child; Child, Preschool; Comorbidity; Crohn Dise

2011
Valproic Acid related metabolic syndrome in patients with epilepsy.
    Georgian medical news, 2011, Issue:194

    Topics: Adult; Anticonvulsants; Blood Glucose; Body Mass Index; Carbamazepine; Cholesterol, HDL; Epilepsy; F

2011
Clinical and pharmacy utilization outcomes with brand to generic antiepileptic switches in patients with epilepsy.
    Epilepsia, 2011, Volume: 52, Issue:7

    Topics: Anticonvulsants; Drug Substitution; Drugs, Generic; Emergency Service, Hospital; Epilepsy; Female; H

2011
Hyperammonemic encephalopathy related to valproate, phenobarbital, and topiramate synergism.
    Epilepsy & behavior : E&B, 2011, Volume: 21, Issue:4

    Topics: Drug Synergism; Drug Therapy, Combination; Epilepsy; Female; Fructose; Humans; Hyperammonemia; Middl

2011
Levetiracetam compared to valproic acid: plasma concentration levels, adverse effects and interactions in aneurysmal subarachnoid hemorrhage.
    Clinical neurology and neurosurgery, 2011, Volume: 113, Issue:8

    Topics: Administration, Oral; Aged; Aneurysm, Ruptured; Anti-Bacterial Agents; Anticonvulsants; Biological A

2011
Haematological side effects of antiepileptic drug treatment in patients with epilepsy.
    Acta neurologica Scandinavica. Supplementum, 2011, Issue:191

    Topics: Adolescent; Adult; Anticonvulsants; Blood Platelets; Carbamazepine; Cross-Sectional Studies; Epileps

2011
The neuroprotective effect of curcumin and Nigella sativa oil against oxidative stress in the pilocarpine model of epilepsy: a comparison with valproate.
    Neurochemical research, 2011, Volume: 36, Issue:11

    Topics: Acetylcholinesterase; Animals; Curcumin; Epilepsy; Glutathione; Hippocampus; Lipid Peroxidation; Nig

2011
Antiepileptic drug use during pregnancy: perinatal outcomes.
    Seizure, 2011, Volume: 20, Issue:9

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Carbamazepine; Cohort Studies; Drug

2011
Association of genetic variants in six candidate genes with valproic acid therapy optimization.
    Pharmacogenomics, 2011, Volume: 12, Issue:8

    Topics: Adult; Alleles; Anticonvulsants; DNA; Epilepsy; Epilepsy, Generalized; Female; Gene Frequency; Genet

2011
Simple and accurate quantitative analysis of ten antiepileptic drugs in human plasma by liquid chromatography/tandem mass spectrometry.
    Journal of pharmaceutical and biomedical analysis, 2011, Dec-05, Volume: 56, Issue:4

    Topics: Anticonvulsants; Calibration; Carbamazepine; Chromatography, Liquid; Drug Monitoring; Drug Stability

2011
The consequences of valproate overdose.
    Clinical chemistry, 2011, Volume: 57, Issue:9

    Topics: Acid-Base Equilibrium; Acidosis, Lactic; Adult; Anticonvulsants; Carnitine; Drug Overdose; Epilepsy;

2011
The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium.
    Disease models & mechanisms, 2012, Volume: 5, Issue:1

    Topics: Animals; Anticonvulsants; Dictyostelium; Disease Models, Animal; Dose-Response Relationship, Drug; E

2012
The prescribing of antiepileptic drugs for pregnant Australian women.
    The Australian & New Zealand journal of obstetrics & gynaecology, 2012, Volume: 52, Issue:1

    Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Australia; Epilepsy; Female; Fetus; Humans; Log

2012
[Effects of valproate sodium on pituitary gonadotropin in adolescent girls with epilepsy].
    Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2011, Volume: 13, Issue:9

    Topics: Adolescent; Anticonvulsants; Child; Epilepsy; Female; Gonadotropins, Pituitary; Humans; Valproic Aci

2011
[Epilepsy in elderly].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2011, Volume: 111, Issue:7

    Topics: Aged; Aged, 80 and over; Aging; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsies,

2011
Acoustic startle hypersensitivity in Mceph mice and its effect on hippocampal excitability.
    The European journal of neuroscience, 2011, Volume: 34, Issue:7

    Topics: Acoustic Stimulation; Animals; Astrocytes; Epilepsy; Glial Fibrillary Acidic Protein; Hippocampus; K

2011
A case of hyperammonaemic encephalopathy due to valproic acid.
    The Netherlands journal of medicine, 2011, Volume: 69, Issue:9

    Topics: Anticonvulsants; Epilepsy; Humans; Hyperammonemia; Male; Middle Aged; Neurotoxicity Syndromes; Valpr

2011
Use of antiepileptic medications in pregnancy in relation to risks of birth defects.
    Annals of epidemiology, 2011, Volume: 21, Issue:11

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Hu

2011
Antiepleptic drug interactions: a clinical case demonstration.
    Casopis lekaru ceskych, 2011, Volume: 150, Issue:8

    Topics: Adolescent; Anticonvulsants; Brain; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epi

2011
Valproate and lamotrigine in children and adolescents with drop attacks: follow-up after the first year.
    Epilepsia, 2011, Volume: 52, Issue:11

    Topics: Anticonvulsants; Benzodiazepines; Epilepsy; Female; Humans; Male; Triazines; Valproic Acid

2011
Simultaneous determination of valproic acid and 2-propyl-4-pentenoic acid for the prediction of clinical adverse effects in Chinese patients with epilepsy.
    Seizure, 2012, Volume: 21, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Child; China; Chromatography, High Pressure Liquid; Epilepsy; Fa

2012
Synthesis and anticonvulsant evaluation of dimethylethanolamine analogues of valproic acid and its tetramethylcyclopropyl analogue.
    Epilepsy research, 2012, Volume: 98, Issue:2-3

    Topics: Animals; Anticonvulsants; Brain Waves; Convulsants; Cyclopropanes; Deanol; Disease Models, Animal; E

2012
Investigating the role of zinc in a rat model of epilepsy.
    CNS neuroscience & therapeutics, 2012, Volume: 18, Issue:4

    Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Epilepsy; Hippocampus; Male; Pilocarpine

2012
Cancer risk in people with epilepsy using valproate-sodium.
    Acta neurologica Scandinavica, 2012, Volume: 125, Issue:4

    Topics: Adult; Causality; Comorbidity; Epilepsy; Female; Humans; Incidence; Male; Middle Aged; Neoplasms; Pr

2012
Effects of long-term antiepileptic drug monotherapy on vascular risk factors and atherosclerosis.
    Epilepsia, 2012, Volume: 53, Issue:1

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Atherosclerosis; Blood Glucose; Carbamazepine; Carotid Art

2012
[Effects of magnesium valproate on endocrine system and reproductive functions of female epileptics].
    Zhonghua yi xue za zhi, 2011, Aug-09, Volume: 91, Issue:29

    Topics: Adolescent; Adult; Child; Endocrine System; Epilepsy; Female; Follicle Stimulating Hormone; Humans;

2011
Evaluation of subclinical hypothyroidism in ambulatory children with controlled epilepsy on valproate monotherapy.
    Journal of child neurology, 2012, Volume: 27, Issue:5

    Topics: Adolescent; Ambulatory Care; Antibodies; Anticonvulsants; Case-Control Studies; Child; Child, Presch

2012
Superoxide dismutase 2 Val16Ala polymorphism is a risk factor for the valproic acid-related elevation of serum aminotransferases.
    Epilepsy research, 2012, Volume: 99, Issue:1-2

    Topics: Adolescent; Adult; Aged; Alanine; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; M

2012
Vulnerability of an epileptic case to psychosis: sodium valproate with lamotrigine, forced normalization, postictal psychosis or all?
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2012, Volume: 33, Issue:5

    Topics: Adult; Age of Onset; Anticonvulsants; Child; Drug Therapy, Combination; Electroencephalography; Epil

2012
Valproate effects on generalized spike-wave discharges and photoparoxysmal response.
    Epilepsia, 2011, Volume: 52, Issue:12

    Topics: Anticonvulsants; Epilepsy; Humans; Photic Stimulation; Valproic Acid

2011
The effects of antiepileptic drugs on the relationships between leptin levels and bone turnover in prepubertal children with epilepsy.
    Journal of pediatric endocrinology & metabolism : JPEM, 2011, Volume: 24, Issue:9-10

    Topics: Anticonvulsants; Biomarkers; Bone Density; Bone Remodeling; Carbamazepine; Child; Child, Preschool;

2011
Fasting insulin and HOMA-index changes in patients treated with valproic acid.
    Georgian medical news, 2011, Issue:199

    Topics: Adult; Blood Glucose; Body Mass Index; C-Peptide; Carbamazepine; Cholesterol, HDL; Epilepsy; Female;

2011
Comparative efficacy of combination drug therapy in refractory epilepsy.
    Neurology, 2012, Jan-03, Volume: 78, Issue:1

    Topics: Anticonvulsants; Developmental Disabilities; Drug Therapy, Combination; Epilepsy; Female; Humans; La

2012
[Lamotrigine add-on therapy for childhood-onset refractory epilepsy: comparison of the efficacy between 3 months and 6 months after initiation].
    No to hattatsu = Brain and development, 2011, Volume: 43, Issue:6

    Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination

2011
Apparent clearance of valproic acid in elderly epileptic patients: estimation of the confounding effect of albumin concentration.
    Upsala journal of medical sciences, 2012, Volume: 117, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Child; Epilepsy; Female; Humans; Male;

2012
Anticonvulsant profile of caprylic acid, a main constituent of the medium-chain triglyceride (MCT) ketogenic diet, in mice.
    Neuropharmacology, 2012, Volume: 62, Issue:4

    Topics: Animals; Anticonvulsants; Brain; Caprylates; Dose-Response Relationship, Drug; Epilepsy; Male; Mice;

2012
Analysis of acylcarnitine levels by tandem mass spectrometry in epileptic children receiving valproate and oxcarbazepine.
    Epileptic disorders : international epilepsy journal with videotape, 2011, Volume: 13, Issue:4

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Carnitine; Child; Child, Preschool; Chromatography, High

2011
[Epileptic asystole - a case report].
    Kardiologia polska, 2012, Volume: 70, Issue:1

    Topics: Anticonvulsants; Electroencephalography; Epilepsy; Female; Heart Arrest; Humans; Middle Aged; Pacema

2012
[Neurology].
    Revue medicale suisse, 2012, Jan-11, Volume: 8, Issue:323

    Topics: Antibodies, Monoclonal; Anticonvulsants; Atrial Fibrillation; Carbamates; Chronic Disease; Deep Brai

2012
Long term effects of tetramine poisoning: an observational study.
    Clinical toxicology (Philadelphia, Pa.), 2012, Volume: 50, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Anticonvulsants; Bridged-Ring Compounds; Charco

2012
[Effects of sodium valproate on neutrophils' oxidative metabolism and oxidant status in children with idiopathic epilepsy].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2011, Volume: 49, Issue:10

    Topics: Anticonvulsants; Antioxidants; Case-Control Studies; Catalase; Child; Child, Preschool; Epilepsy; Fe

2011
Valproate and the risk for congenital malformations: Is formulation and dosage regime important?
    Seizure, 2012, Volume: 21, Issue:3

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complic

2012
Thyroid hormones may contribute to vascular risk factors and atherosclerosis.
    Epilepsia, 2012, Volume: 53, Issue:4

    Topics: Anticonvulsants; Atherosclerosis; Carbamazepine; Carotid Artery, Common; Epilepsy; Female; Humans; M

2012
Influence of UDP-glucuronosyltransferase polymorphisms on valproic acid pharmacokinetics in Chinese epilepsy patients.
    European journal of clinical pharmacology, 2012, Volume: 68, Issue:10

    Topics: Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Epilepsy; Female; Glucuronosyltransfer

2012
Characterization of glucose homeostasis and lipid profile in adult, seizure-free, epileptic patients in Asian population.
    European journal of neurology, 2012, Volume: 19, Issue:9

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Asian People; Blood Glucose; Cholesterol, LDL; Cross-Secti

2012
Economic evaluation of anti-epileptic drug therapies with specific focus on teratogenic outcomes.
    Journal of medical economics, 2012, Volume: 15, Issue:5

    Topics: Abnormalities, Drug-Induced; Adolescent; Anticonvulsants; Carbamazepine; Cost-Benefit Analysis; Epil

2012
Seizure management at Auckland City Hospital Emergency Department between July and December 2009: time for a change?
    Internal medicine journal, 2012, Volume: 42, Issue:9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Disease Management; Emer

2012
Risk factors for hyperammonemia associated with valproic acid therapy in adult epilepsy patients.
    Epilepsy research, 2012, Volume: 101, Issue:3

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Female; Humans

2012
Prevalence, utilization, and costs of antiepileptic drugs for epilepsy in Germany--a nationwide population-based study in children and adults.
    Journal of neurology, 2012, Volume: 259, Issue:11

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Databases, Factual; Epilepsy; German

2012
Evaluation of the antiepileptic effect of curcumin and Nigella sativa oil in the pilocarpine model of epilepsy in comparison with valproate.
    Epilepsy & behavior : E&B, 2012, Volume: 24, Issue:2

    Topics: Amino Acids; Animals; Anticonvulsants; Behavior, Animal; Cerebral Cortex; Chromatography, High Press

2012
Valproate induces epigenetic modifications in lymphomonocytes from epileptic patients.
    Progress in neuro-psychopharmacology & biological psychiatry, 2012, Oct-01, Volume: 39, Issue:1

    Topics: Acetylation; Adult; Anticonvulsants; Case-Control Studies; DNA Methylation; Dose-Response Relationsh

2012
The effect of combination therapy on the plasma concentrations of traditional antiepileptics: a retrospective study.
    Human & experimental toxicology, 2012, Volume: 31, Issue:10

    Topics: Adolescent; Adult; Age Factors; Aged; Analysis of Variance; Anticonvulsants; Carbamazepine; Drug Int

2012
Subclinical hypothyroidism during valproic acid therapy in children and adolescents with epilepsy.
    Neuropediatrics, 2012, Volume: 43, Issue:3

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Humans; Hypothyroidism; Severity of

2012
Plasma leptin, neuropeptide Y, ghrelin, and adiponectin levels and carotid artery intima media thickness in epileptic children treated with valproate.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2012, Volume: 28, Issue:7

    Topics: Adiponectin; Age Factors; Anticonvulsants; Blood Glucose; Body Mass Index; Carotid Intima-Media Thic

2012
A retrospective study on the usage of antiepileptic drugs in Asian children from 2000 to 2009 in the largest pediatric hospital in Singapore.
    Pharmacoepidemiology and drug safety, 2012, Volume: 21, Issue:10

    Topics: Anticonvulsants; Asia; Child; Epilepsy; Female; History, 21st Century; Hospitals, Pediatric; Humans;

2012
Correlation between plasma ammonia level and serum trough concentration of free valproic acid in patients with epilepsy.
    Biological & pharmaceutical bulletin, 2012, Volume: 35, Issue:6

    Topics: Adolescent; Adult; Ammonia; Anticonvulsants; Asian People; Child; Child, Preschool; Epilepsy; Female

2012
Hallucinations after withdrawal of valproic acid.
    Pediatrics, 2012, Volume: 130, Issue:1

    Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Hallucinations; Humans; Substance Withdr

2012
Late adverse effects of the coadministration of valproate and lamotrigine.
    Pediatric neurology, 2012, Volume: 47, Issue:1

    Topics: Adolescent; Anticonvulsants; Ataxia; Child; Drug Therapy, Combination; Epilepsy; Female; Headache; H

2012
Valproate-acid-induced cutaneous leukocytoclastic vasculitis.
    Psychiatria Danubina, 2012, Volume: 24, Issue:2

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Valproic Acid; Vasculitis, Leukocytoclastic, Cutan

2012
Metabolic syndrome among Chinese obese patients with epilepsy on sodium valproate.
    Seizure, 2012, Volume: 21, Issue:8

    Topics: Adolescent; Adult; Anticonvulsants; Asian People; Epilepsy; Female; Humans; Male; Metabolic Syndrome

2012
Development and validation of a bioanalytical LC-UV method with solid-phase extraction for determination of valproic acid in saliva.
    Acta pharmaceutica (Zagreb, Croatia), 2012, Volume: 62, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Biopharmaceutics; Calibration; Chromatography, High Pressure Liq

2012
Sodium valproate for epilepsy in rural China: an efficacy and safety assessment in primary care.
    Epilepsy research, 2012, Volume: 102, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Child; China; Epilepsy; Female; Follow-

2012
Primary afterdischarge in organotypic hippocampal slice cultures: effects of standard antiepileptic drugs.
    Epilepsia, 2012, Volume: 53, Issue:11

    Topics: Action Potentials; Animals; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Epilepsy; H

2012
Teratogenesis in repeated pregnancies in antiepileptic drug-treated women.
    Epilepsia, 2013, Volume: 54, Issue:1

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Australia; Epilepsy; Female; Humans; Parity; Pregnancy

2013
Randomised controlled monotherapy trials: which comparators to use?
    Epileptic disorders : international epilepsy journal with videotape, 2012, Volume: 14, Issue:3

    Topics: Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; Humans; Seizures; Valproic Acid

2012
Rufinamide in children with refractory epilepsy: pharmacokinetics, efficacy, and safety.
    Neuropediatrics, 2012, Volume: 43, Issue:5

    Topics: Adolescent; Analysis of Variance; Anticonvulsants; Child; Child, Preschool; Chromatography, High Pre

2012
Polycystic ovary syndrome in patients with epilepsy: a study in 102 Chinese women.
    Seizure, 2012, Volume: 21, Issue:9

    Topics: Adolescent; Adult; Asian People; Biomarkers; Child; Epilepsy; Female; Follicle Stimulating Hormone;

2012
Lamotrigine related myocarditis: case report.
    Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir, 2012, Volume: 40, Issue:4

    Topics: Adolescent; Anticonvulsants; Electrocardiography; Epilepsy; Humans; Lamotrigine; Magnetic Resonance

2012
Therapeutic drug monitoring of free fraction valproic acid in patients with hypoalbuminaemia.
    The Netherlands journal of medicine, 2012, Volume: 70, Issue:7

    Topics: Anticonvulsants; Epilepsy; Fatal Outcome; Humans; Hypoalbuminemia; Male; Middle Aged; Valproic Acid

2012
Arginase deficiency with new phenotype and a novel mutation: contemporary summary.
    Pediatric neurology, 2012, Volume: 47, Issue:4

    Topics: Anticonvulsants; Arginase; Base Sequence; Carcinoma, Hepatocellular; Cerebral Palsy; Codon, Nonsense

2012
[Efficacy of the specific prolonged form of valproic acid (in the form of granules) in children with different forms of epilepsy].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2012, Volume: 112, Issue:6 Pt 2

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Delayed-Action Preparations; Epilepsy; Humans;

2012
The role of ethanol on the anticonvulsant effect of valproic acid and cortical microvascular changes after epileptogenesis in mice.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2013, Volume: 34, Issue:7

    Topics: Animals; Anticonvulsants; Cerebral Cortex; Cerebrovascular Circulation; Drug Synergism; Drug Therapy

2013
Asymmetric dimethylarginine may contribute to vascular risk factors in patients receiving antiepileptic drug treatment.
    Epilepsia, 2012, Volume: 53, Issue:10

    Topics: Anticonvulsants; Atherosclerosis; Carbamazepine; Carotid Artery, Common; Epilepsy; Female; Humans; M

2012
Comparative stroke risk of antiepileptic drugs in patients with epilepsy.
    Epilepsia, 2013, Volume: 54, Issue:1

    Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Male

2013
Epileptiform activity and cognitive deficits in SNAP-25(+/-) mice are normalized by antiepileptic drugs.
    Cerebral cortex (New York, N.Y. : 1991), 2014, Volume: 24, Issue:2

    Topics: Animals; Anticonvulsants; Association Learning; Brain; Carbamazepine; Cognition Disorders; Epilepsy;

2014
Evaluation of the possible epileptogenic activity of ciprofloxacin: the role of Nigella sativa on amino acids neurotransmitters.
    Neurochemical research, 2013, Volume: 38, Issue:1

    Topics: Amino Acids; Animals; Anti-Bacterial Agents; Anticonvulsants; Antioxidants; Brain Chemistry; Chromat

2013
[Pharmacological interaction between meropenem and valproic acid: a report of two cases].
    Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia, 2012, Volume: 29, Issue:3

    Topics: Anticonvulsants; beta-Lactamase Inhibitors; Child, Preschool; Drug Interactions; Epilepsy; Fatal Out

2012
Effects of UGT1A6, UGT2B7, and CYP2C9 genotypes on plasma concentrations of valproic acid in Chinese children with epilepsy.
    Drug metabolism and pharmacokinetics, 2012, Volume: 27, Issue:5

    Topics: Aryl Hydrocarbon Hydroxylases; Asian People; Child; Cytochrome P-450 CYP2C9; Epilepsy; Female; Genot

2012
[Valproic acid pharmacogenetics in an individual approach to treatment of women of childbearing age with epilepsy].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2011, Volume: 111, Issue:5 Pt 2

    Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Epilepsy; Female; Fertility

2011
[Stigmata of dysembryogenesis and physical development in children born to mothers with epilepsy].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2011, Volume: 111, Issue:5 Pt 2

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child Development; Child, Preschool; Developmental Dis

2011
Carbamazepine, but not valproate, displays pharmacoresistance in lamotrigine-resistant amygdala kindled rats.
    Epilepsy research, 2013, Volume: 104, Issue:1-2

    Topics: Amygdala; Animals; Anticonvulsants; Carbamazepine; Drug Resistance; Epilepsy; Kindling, Neurologic;

2013
Zinc/Aluminum layered double hydroxide-titanium dioxide composite nanosheet film as novel solid phase microextraction fiber for the gas chromatographic determination of valproic acid.
    Talanta, 2013, Jan-15, Volume: 103

    Topics: Aluminum Hydroxide; Anticonvulsants; Chromatography, Gas; Epilepsy; Humans; Hydrogen-Ion Concentrati

2013
How did phenobarbital's chemical structure affect the development of subsequent antiepileptic drugs (AEDs)?
    Epilepsia, 2012, Volume: 53 Suppl 8

    Topics: Anticonvulsants; Carbamazepine; Drug Discovery; Epilepsy; Ethosuximide; History, 20th Century; Human

2012
Valproate-associated reproductive hormone abnormalities: do bipolar men have the same risk as epileptic men?
    Turk psikiyatri dergisi = Turkish journal of psychiatry, 2012,Winter, Volume: 23, Issue:4

    Topics: Adolescent; Adult; Animals; Anticonvulsants; Bipolar Disorder; Disease Models, Animal; Endocrine Sys

2012
A reversible cause of coma in epilepsy.
    BMJ case reports, 2012, Dec-13, Volume: 2012

    Topics: Adolescent; Anticonvulsants; Coma; Epilepsy; Female; Humans; Hyperammonemia; Valproic Acid

2012
Valproate (VPA)-associated hyperammonemic encephalopathy independent of elevated serum VPA levels: 21 cases in China from May 2000 to May 2012.
    Comprehensive psychiatry, 2013, Volume: 54, Issue:5

    Topics: Adolescent; Adult; Aged; Child, Preschool; China; Epilepsy; Female; Humans; Hyperammonemia; Male; Me

2013
Effect of pregabalin add-on treatment on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy: a pilot study.
    Epileptic disorders : international epilepsy journal with videotape, 2012, Volume: 14, Issue:4

    Topics: Adult; Aged; Anticonvulsants; Anxiety; Benzodiazepines; Brain Neoplasms; Carbamazepine; Clobazam; Dr

2012
Assessment of atherosclerosis risk due to the homocysteine-asymmetric dimethylarginine-nitric oxide cascade in children taking antiepileptic drugs.
    Seizure, 2013, Volume: 22, Issue:2

    Topics: Adolescent; Anticonvulsants; Arginine; Atherosclerosis; Biomarkers; Carbamazepine; Child; Epilepsy;

2013
Seizure control with antiepileptic drug therapy in 517 consecutive adult outpatients at the Kork Epilepsy Centre.
    Epileptic disorders : international epilepsy journal with videotape, 2012, Volume: 14, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ambulatory Care; Anticonvulsants; Carbamazepine; Cross-S

2012
Importance of accurate measurement of carotid intima-media thickness for evaluating epileptic children treated with valproate.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2013, Volume: 29, Issue:3

    Topics: Adiponectin; Anticonvulsants; Carotid Intima-Media Thickness; Epilepsy; Female; Ghrelin; Humans; Lep

2013
Reply from the authors of the article entitled "Importance of accurate measurement of carotid intima media thickness for evaluating epileptic children treated with valproate".
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2013, Volume: 29, Issue:3

    Topics: Adiponectin; Anticonvulsants; Carotid Intima-Media Thickness; Epilepsy; Female; Ghrelin; Humans; Lep

2013
[Valproic acid-induced idiosyncratic liver injury in 4 cases].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2012, Volume: 50, Issue:12

    Topics: Anticonvulsants; Biomarkers; Carnitine; Chemical and Drug Induced Liver Injury; Child; Child, Presch

2012
Spatiotemporal dynamics of high-K+-induced epileptiform discharges in hippocampal slice and the effects of valproate.
    Neuroscience bulletin, 2013, Volume: 29, Issue:1

    Topics: Animals; Anticonvulsants; Brain Mapping; CA3 Region, Hippocampal; Disease Models, Animal; Epilepsy;

2013
Polycystic ovaries, obesity and insulin resistance in women with epilepsy. A comparative study of carbamazepine and valproic acid in 105 women.
    Journal of neurology, 2002, Volume: 249, Issue:7

    Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Insulin Resistance; Obesity; Polycy

2002
Valproate-associated dysmyelopoiesis in elderly patients.
    American journal of clinical pathology, 2002, Volume: 118, Issue:2

    Topics: Anticonvulsants; Epilepsy; Female; Humans; Male; Middle Aged; Myelodysplastic Syndromes; Valproic Ac

2002
Valproate embryopathy in three sets of siblings: further proof of hereditary susceptibility.
    Neurology, 2002, Aug-27, Volume: 59, Issue:4

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child; Child, Preschool; Developmental Disabil

2002
Valproate-induced encephalopathy: assessment with MR imaging and 1H MR spectroscopy.
    Epilepsia, 2002, Volume: 43, Issue:9

    Topics: Adult; Anticonvulsants; Aspartic Acid; Brain; Brain Diseases, Metabolic; Choline; Creatine; Epilepsy

2002
Effects of antiepileptic drugs on induced epileptiform activity in a rat model of dysplasia.
    Epilepsy research, 2002, Volume: 50, Issue:3

    Topics: 4-Aminopyridine; Action Potentials; Animals; Animals, Newborn; Anticonvulsants; Carbamazepine; Disea

2002
Studies on the pharmacokinetics of total and free valproate in mono- and bitherapy with carbamazepine in epileptic children and adolescents.
    Folia neuropathologica, 2002, Volume: 40, Issue:2

    Topics: Adolescent; Carbamazepine; Child; Child, Preschool; Circadian Rhythm; Drug Therapy, Combination; Epi

2002
[Clinical features and treatment of refractory epilepsy in children].
    Rinsho shinkeigaku = Clinical neurology, 2001, Volume: 41, Issue:12

    Topics: Adolescent; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam

2001
Letter to the editor. Discordant twins for neural tube defect on treatment with sodium valproate.
    Seizure, 2002, Volume: 11, Issue:7

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Neural Tube Defects; Pregnancy; Prenatal Exposure

2002
Does lamotrigine influence valproate concentrations?
    Therapeutic drug monitoring, 2002, Volume: 24, Issue:5

    Topics: Adolescent; Adult; Analysis of Variance; Child; Child, Preschool; Drug Interactions; Epilepsy; Femal

2002
Fanconi syndrome caused by sodium valproate: report of three severely disabled children.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2002, Volume: 6, Issue:3

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Disabled Children; Epilepsy; Fanconi Syndrome;

2002
Anticonvulsant actions of gap junctional blockers in an in vitro seizure model.
    Journal of neurophysiology, 2002, Volume: 88, Issue:4

    Topics: 1-Octanol; Action Potentials; Ammonium Chloride; Animals; Anticonvulsants; Carbenoxolone; Connexins;

2002
Therapy of Sneddon syndrome.
    European neurology, 2002, Volume: 48, Issue:3

    Topics: Adult; Antibodies, Antiphospholipid; Anticonvulsants; Aspirin; Azathioprine; Clopidogrel; Drug Thera

2002
[Convulex and its place in epilepsy treatment with original valproates].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2002, Volume: 102, Issue:9

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Cost-Benefit Analysis; Epilepsy; Female; Humans; Ma

2002
[Use of convulex in patients with epilepsy with and without affective disorders].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2002, Volume: 102, Issue:9

    Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Gen

2002
Serum lipids, vitamin B12 and folic acid levels in children receiving long-term valproate therapy.
    Acta neurologica Belgica, 2002, Volume: 102, Issue:3

    Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Folic Acid; Humans; Infant; Lipids; Male

2002
Aggregate data meta-analysis with time-to-event outcomes.
    Statistics in medicine, 2002, Nov-30, Volume: 21, Issue:22

    Topics: Anticonvulsants; Carbamazepine; Cerebral Palsy; Cohort Studies; Epilepsy; Female; Humans; Life Table

2002
Predictors of ovulatory failure in women with epilepsy.
    Annals of neurology, 2002, Volume: 52, Issue:6

    Topics: Adolescent; Adult; Analysis of Variance; Anovulation; Anticonvulsants; Chi-Square Distribution; Epil

2002
Outcome of pregnancy in women attending an outpatient epilepsy clinic: adverse features associated with higher doses of sodium valproate.
    Seizure, 2002, Volume: 11, Issue:8

    Topics: Abnormalities, Drug-Induced; Adolescent; Anticonvulsants; Child; Child, Preschool; Dose-Response Rel

2002
Anticonvulsant valproate reduces seizure-susceptibility in mutant Drosophila.
    Brain research, 2002, Dec-20, Volume: 958, Issue:1

    Topics: Action Potentials; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Dru

2002
Population pharmacokinetics of intravenous valproic acid in Korean patients.
    Journal of clinical pharmacy and therapeutics, 2002, Volume: 27, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Asian People; Bayes Theorem; Body Mass

2002
Amino acid conjugates: metabolites of 2-propylpentanoic acid (valproic acid) in epileptic patients.
    Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:1

    Topics: Adolescent; Amino Acids; Child; Epilepsy; Esters; Gas Chromatography-Mass Spectrometry; Humans; Valp

2003
Valproic acid and lamotrigine treatment during pregnancy. The risk of chromosomal abnormality.
    Mutation research, 2003, Jan-10, Volume: 534, Issue:1-2

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anticonvulsants; Chromosome Aberrations

2003
Landau-Kleffner syndrome beginning with stuttering: case report.
    Journal of child neurology, 2002, Volume: 17, Issue:10

    Topics: Adrenocorticotropic Hormone; Aphasia; Child, Preschool; Diagnosis, Differential; Electroencephalogra

2002
Valproate-associated reproductive and metabolic abnormalities: are epileptic women at greater risk than bipolar women?
    Progress in neuro-psychopharmacology & biological psychiatry, 2003, Volume: 27, Issue:1

    Topics: Adult; Antimanic Agents; Bipolar Disorder; Cross-Sectional Studies; Endocrine System; Epilepsy; Fema

2003
Oral/intravenous maintenance dosing of valproate following intravenous loading: a simulation.
    Epilepsy research, 2003, Volume: 53, Issue:1-2

    Topics: Administration, Oral; Adult; Aging; Algorithms; Anticonvulsants; Child; Computer Simulation; Delayed

2003
Effects of valproate and carbamazepine on serum levels of homocysteine, vitamin B12, and folic acid.
    Brain & development, 2003, Volume: 25, Issue:2

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Folic Acid; H

2003
Does long-term use of valproate cause weight gain in prepubertal epileptic children?
    The International journal of neuroscience, 2002, Volume: 112, Issue:10

    Topics: Anticonvulsants; Body Mass Index; Child; Epilepsy; Female; Humans; Leptin; Male; Time; Valproic Acid

2002
Major malformations in offspring of women with epilepsy.
    Neurology, 2003, Feb-25, Volume: 60, Issue:4

    Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Comorbidity; Educational Status;

2003
Comparison of lamotrigine and valproate with respect to quality of life.
    Epilepsy & behavior : E&B, 2003, Volume: 4, Issue:1

    Topics: Anticonvulsants; Epilepsy; Humans; Lamotrigine; Quality of Life; Triazines; Valproic Acid

2003
Effects of age and polytherapy, risk factors of valproic acid (VPA) hepatotoxicity, on the excretion of thiol conjugates of (E)-2,4-diene VPA in people with epilepsy taking VPA.
    Epilepsia, 2003, Volume: 44, Issue:3

    Topics: Acetylcysteine; Adolescent; Adult; Age Factors; Anticonvulsants; Chemical and Drug Induced Liver Inj

2003
No effect of long-term valproate therapy on thyroid and parathyroid functions in children.
    The International journal of neuroscience, 2002, Volume: 112, Issue:11

    Topics: Adolescent; Alkaline Phosphatase; Calcium; Child; Child, Preschool; Epilepsy; Humans; Infant; Osteoc

2002
Immunoglobulins in children with epilepsy: the Dutch Study of Epilepsy in Childhood.
    Clinical and experimental immunology, 2003, Volume: 132, Issue:1

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Case-Control Studies; Chi-Square Distribution; Child; Ch

2003
Carnitine level in Chinese epileptic patients taking sodium valproate.
    Pediatric neurology, 2003, Volume: 28, Issue:1

    Topics: Adolescent; Anticonvulsants; Asian People; Carnitine; Child; Epilepsy; Female; Humans; Male; Metabol

2003
Favorable outcome of epileptic blindness in children.
    Journal of child neurology, 2003, Volume: 18, Issue:1

    Topics: Acute Disease; Adolescent; Anticonvulsants; Blindness, Cortical; Carbamazepine; Child; Electroenceph

2003
Evaluation of therapeutic drug monitoring of antiepileptic drugs.
    International journal of clinical pharmacology and therapeutics, 2003, Volume: 41, Issue:3

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dose-Response Rela

2003
Volume-selective 1H MR spectroscopy for in vivo detection of valproate in patients with epilepsy.
    Neuroradiology, 2003, Volume: 45, Issue:5

    Topics: Adult; Anticonvulsants; Brain Chemistry; Epilepsy; Female; Humans; Magnetic Resonance Spectroscopy;

2003
Antiepileptic drug hypersensitivity syndrome in a patient treated with valproate.
    British journal of clinical pharmacology, 2003, Volume: 55, Issue:4

    Topics: Adult; Anticonvulsants; Drug Eruptions; Drug Hypersensitivity; Epilepsy; Humans; Hyperplasia; Lymph

2003
Hypouricemia in severely disabled children: influence of valproic acid and bed-ridden state.
    Brain & development, 2003, Volume: 25, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Disabled Children; Epilepsy; Female; Hu

2003
Uptake of GABA and activity of GABA-transaminase in platelets from epileptic patients.
    Epilepsy research, 2003, Volume: 53, Issue:3

    Topics: 4-Aminobutyrate Transaminase; Adult; Anticonvulsants; Blood Platelets; Case-Control Studies; Dose-Re

2003
Valproic acid-associated weight gain in older children and teens with epilepsy.
    Pediatric neurology, 2003, Volume: 28, Issue:2

    Topics: Adolescent; Anticonvulsants; Body Mass Index; Child; Epilepsy; Female; Follow-Up Studies; Humans; Ma

2003
[Effects of valproate on sexual development].
    Anales de pediatria (Barcelona, Spain : 2003), 2003, Volume: 58, Issue:5

    Topics: Age Determination by Skeleton; Anthropometry; Anticonvulsants; Child; Epilepsy; Female; Gonadal Ster

2003
Effects of valproic acid, carbamazepine, and phenobarbitone on the fatty acid composition of erythrocyte membranes in children.
    Epilepsia, 2003, Volume: 44, Issue:5

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Erythrocyte Membrane;

2003
Safety and efficacy of intravenous valproate in pediatric status epilepticus and acute repetitive seizures.
    Epilepsia, 2003, Volume: 44, Issue:5

    Topics: Acute Disease; Adolescent; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Dru

2003
Do epileptic children treated with valproate have a risk of excessive weight gain?
    Journal of child neurology, 2003, Volume: 18, Issue:4

    Topics: Age Factors; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Obesi

2003
Higher androgens and weight gain with valproate compared with lamotrigine for epilepsy.
    Epilepsy research, 2003, Volume: 54, Issue:2-3

    Topics: Adult; Analysis of Variance; Androgens; Confidence Intervals; Cross-Sectional Studies; Epilepsy; Fem

2003
HPLC determination of valproic acid in human serum.
    Die Pharmazie, 2003, Volume: 58, Issue:6

    Topics: Anticonvulsants; Chromatography, High Pressure Liquid; Epilepsy; Humans; Reference Standards; Reprod

2003
Direct observation of 3-keto-valproate in urine by 2D-NMR spectroscopy.
    Clinica chimica acta; international journal of clinical chemistry, 2003, Volume: 334, Issue:1-2

    Topics: Adolescent; Anticonvulsants; Consanguinity; Epilepsy; Humans; Indicators and Reagents; Ketones; Magn

2003
Lamotrigine and valproate: efficacy of co-administration in a pediatric population.
    Pediatric neurology, 2003, Volume: 28, Issue:5

    Topics: Adolescent; Ambulatory Care; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Female; F

2003
Reversible altered consciousness with brain atrophy caused by valproic acid.
    Pediatric neurology, 2003, Volume: 28, Issue:5

    Topics: Atrophy; Brain; Child, Preschool; Consciousness Disorders; Electroencephalography; Epilepsy; Female;

2003
Successful pregnancy in a patient with hyperoxaluria and combined liver and renal transplant.
    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2003, Volume: 23, Issue:4

    Topics: Adult; Epilepsy; Female; Humans; Hyperoxaluria; Infant, Newborn; Kidney Transplantation; Liver Trans

2003
Absence seizures in patients with localization-related epilepsy.
    Brain & development, 2003, Volume: 25, Issue:6

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Electroencephalogra

2003
A study of anticonvulsant medication on ovarian function in a group of women with epilepsy who have only ever taken one anticonvulsant compared with a group of women without epilepsy.
    Seizure, 2003, Volume: 12, Issue:6

    Topics: Anticonvulsants; Carbamazepine; Case-Control Studies; Epilepsy; Female; Follicle Stimulating Hormone

2003
EDTA-dependent pseudothrombocytopenia induced by valproic acid.
    Neurology, 2003, Aug-26, Volume: 61, Issue:4

    Topics: Anticonvulsants; Diagnostic Errors; Edetic Acid; Epilepsy; False Positive Reactions; Female; Heparin

2003
Alterations in semen parameters in men with epilepsy treated with valproate or carbamazepine monotherapy.
    European journal of neurology, 2003, Volume: 10, Issue:5

    Topics: Adult; Analysis of Variance; Carbamazepine; Epilepsy; Humans; Male; Semen; Sperm Count; Spermatozoa;

2003
The Australian registry of anti-epileptic drugs in pregnancy: experience after 30 months.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2003, Volume: 10, Issue:5

    Topics: Abortion, Induced; Anticonvulsants; Australia; Carbamazepine; Cohort Studies; Congenital Abnormaliti

2003
[COMMUNICATION CONCERNING 1ST CLINICAL TESTS OF THE ANTICONVULSIVE ACTIVITY OF N-DIPROPYLACETIC ACID (SODIUM SALT)].
    Annales medico-psychologiques, 1964, Volume: 122

    Topics: Adolescent; Anticonvulsants; Child; Electroencephalography; Epilepsy; Fatty Acids; Humans; Sodium; V

1964
[Fetal valproate syndrome].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2003, Aug-28, Volume: 123, Issue:16

    Topics: Anticonvulsants; Epilepsy; Female; Humans; Maternal-Fetal Exchange; Pregnancy; Pregnancy Complicatio

2003
[Influence of valproic acid (depakine I.V.) on human placenta metabolism--experimental model].
    Ginekologia polska, 2003, Volume: 74, Issue:8

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Blood Glucose; Embryo, Mammalian; Embryonic and Fetal

2003
Multiple congenital malformations including generalized hypertrichosis with gum hypertrophy in a child exposed to valproic acid in utero.
    Genetic counseling (Geneva, Switzerland), 2003, Volume: 14, Issue:3

    Topics: Abnormalities, Multiple; Anticonvulsants; Dermatoglyphics; Epilepsy; Fatal Outcome; Female; Gingiva;

2003
[Fetal valproate syndrome].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2003, Oct-09, Volume: 123, Issue:19

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Maternal-Fetal Exchange; Pre

2003
Dynamic release of amino acid transmitters induced by valproate in PTZ-kindled epileptic rat hippocampus.
    Neurochemistry international, 2004, Volume: 44, Issue:4

    Topics: Amino Acid Transport Systems; Amino Acids; Animals; Anticonvulsants; Epilepsy; Hippocampus; Kindling

2004
[A case of infantile epileptic apnea with congenital brain anomaly].
    No to hattatsu = Brain and development, 2003, Volume: 35, Issue:6

    Topics: Apnea; Brain; Electroencephalography; Epilepsy; Female; Humans; Infant; Intellectual Disability; Val

2003
Serum insulin and leptin levels and valproate-associated obesity.
    Epilepsia, 2003, Volume: 44, Issue:12

    Topics: Adult; Anticonvulsants; Body Composition; Body Mass Index; Child; Epilepsy; Feedback; Female; Humans

2003
Pharmacokinetic modelling of valproic acid from routine clinical data in Egyptian epileptic patients.
    European journal of clinical pharmacology, 2004, Volume: 59, Issue:11

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clinical Trials as Topic

2004
Compliance and satisfaction with switching from an immediate-release to sustained-release formulation of valproate in people with epilepsy.
    Epilepsy & behavior : E&B, 2003, Volume: 4, Issue:6

    Topics: Adaptation, Psychological; Adolescent; Adult; Age of Onset; Aged; Anticonvulsants; Delayed-Action Pr

2003
The relationship between treatment with valproate, lamotrigine, and topiramate and the prognosis of the idiopathic generalised epilepsies.
    Journal of neurology, neurosurgery, and psychiatry, 2004, Volume: 75, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Databases, Factual; Electroencephalogra

2004
Normal intelligence in children with prenatal exposure to carbamazepine.
    Neurology, 2004, Jan-13, Volume: 62, Issue:1

    Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsy;

2004
Serum nitrite and nitrate levels in epileptic children using valproic acid or carbamazepine.
    Brain & development, 2004, Volume: 26, Issue:1

    Topics: Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Humans; Male; Nitrates; Nitric Oxide; Nitri

2004
Hypouricemia in severely disabled children II: influence of elemental enteral nutrition on the serum uric acid levels.
    Brain & development, 2004, Volume: 26, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Disabled Children; Enteral Nutrition; E

2004
Epilepsy syndrome, focus location, and treatment choice affect testicular function in men with epilepsy.
    Neurology, 2004, Jan-27, Volume: 62, Issue:2

    Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Epileps

2004
Effect of epilepsy and antiepileptic drugs on male reproductive health.
    Neurology, 2004, Jan-27, Volume: 62, Issue:2

    Topics: Adult; Androstenedione; Anticonvulsants; Carbamazepine; Dehydroepiandrosterone Sulfate; Epilepsies,

2004
[Childhood-onset epileptic blindness--clinical correlates and outcomes].
    Harefuah, 2004, Volume: 143, Issue:1

    Topics: Age of Onset; Anticonvulsants; Blindness; Carbamazepine; Child; Epilepsy; Follow-Up Studies; Humans;

2004
Long-term reproductive endocrine health in young women with epilepsy during puberty.
    Neurology, 2004, Feb-10, Volume: 62, Issue:3

    Topics: Adolescent; Anticonvulsants; Child; Cohort Studies; Comorbidity; Epilepsy; Female; Finland; Follow-U

2004
Interaction between anticonvulsants and human placental carnitine transporter.
    Epilepsia, 2004, Volume: 45, Issue:3

    Topics: Acetates; Amines; Aminoisobutyric Acids; Anticonvulsants; Carnitine; Carrier Proteins; Culture Techn

2004
Cost of epilepsy in patients attending a secondary-level hospital in India.
    Epilepsia, 2004, Volume: 45, Issue:3

    Topics: Anticonvulsants; Carbamazepine; Efficiency, Organizational; Epilepsy; Hospital Costs; Hospitalizatio

2004
[A case of polymyalgia rheumatica with improved steroid-responsibility after discontinuing carbamazepine].
    No to shinkei = Brain and nerve, 2004, Volume: 56, Issue:1

    Topics: Aged; Anticonvulsants; Carbamazepine; Drug Resistance; Epilepsy; Female; Humans; Methotrexate; Polym

2004
The effect of long-term antiepileptic treatment on serum cholesterol (TC, HDL, LDL) and triglyceride levels in adult epileptic patients on monotherapy.
    Medical science monitor : international medical journal of experimental and clinical research, 2004, Volume: 10, Issue:4

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Cholesterol; Cholesterol, HDL; Cholesterol,

2004
Major malformations in infants exposed to antiepileptic drugs in utero, with emphasis on carbamazepine and valproic acid: a nation-wide, population-based register study.
    Acta paediatrica (Oslo, Norway : 1992), 2004, Volume: 93, Issue:2

    Topics: Abnormalities, Multiple; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fetal Diseases; Hu

2004
Nonparametric population modeling of valproate pharmacokinetics in epileptic patients using routine serum monitoring data: implications for dosage.
    Journal of clinical pharmacy and therapeutics, 2004, Volume: 29, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Bayes Theorem; Child; Child, Preschool; Drug Monitoring; Epileps

2004
Drug induced encephalopathy in six epileptic patients: topiramate? valproate? or both?
    Human psychopharmacology, 2004, Volume: 19, Issue:3

    Topics: Adolescent; Adult; Ammonia; Anticonvulsants; Drug Interactions; Drug Therapy, Combination; Electroen

2004
Valproate therapy and nonalcoholic fatty liver disease.
    Annals of neurology, 2004, Volume: 55, Issue:5

    Topics: Adolescent; Adult; Carbamazepine; Chi-Square Distribution; Epilepsy; Fatty Liver; Female; Humans; Ma

2004
Effect of combination of dizocilpine with general antiepileptic drugs on amygdala kindling models in rats.
    Yao xue xue bao = Acta pharmaceutica Sinica, 2004, Volume: 39, Issue:2

    Topics: Amygdala; Animals; Anticonvulsants; Dizocilpine Maleate; Electric Stimulation; Epilepsy; Female; Kin

2004
Divalproex-ER pharmacokinetics in older children and adolescents.
    Pediatric neurology, 2004, Volume: 30, Issue:5

    Topics: Adolescent; Adult; Area Under Curve; Child; Confidence Intervals; Delayed-Action Preparations; Epile

2004
[Insulin resistance in epileptic patients during treatment of valproic acid].
    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2004, Volume: 33, Issue:3

    Topics: Adult; Body Mass Index; Epilepsy; Female; Humans; Insulin Resistance; Male; Valproic Acid; Weight Ga

2004
Serum androgen levels and testicular structure during pubertal maturation in male subjects with epilepsy.
    Epilepsia, 2004, Volume: 45, Issue:7

    Topics: Adolescent; Adult; Androgens; Androstenedione; Anticonvulsants; Carbamazepine; Child; Epilepsy; Huma

2004
Health-related quality of life of people with epilepsy compared with a general reference population: a Tunisian study.
    Epilepsia, 2004, Volume: 45, Issue:7

    Topics: Adolescent; Adult; Ambulatory Care; Anticonvulsants; Case-Control Studies; Cross-Cultural Comparison

2004
Fanconi syndrome caused by antiepileptic therapy with valproic Acid.
    Epilepsia, 2004, Volume: 45, Issue:7

    Topics: Anticonvulsants; Child; Epilepsy; Fanconi Syndrome; Hand; Humans; Male; Radiography; Valproic Acid

2004
The difficulties of diagnosing VPA-induced pancreatitis in children with severe motor and intellectual disabilities.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2004, Volume: 8, Issue:2

    Topics: Acute Disease; Anticonvulsants; Child, Preschool; Epilepsy; Female; Humans; Intellectual Disability;

2004
Casebook: epileptic seizures and turns.
    The Practitioner, 2004, Volume: 248, Issue:1660

    Topics: Adolescent; Adult; Anticonvulsants; Contraindications; Diagnosis, Differential; Epilepsy; Female; Hu

2004
Color vision in epileptic adolescents treated with valproate and carbamazepine.
    Seizure, 2004, Volume: 13, Issue:6

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Color Perception; Epilepsy; Female; Humans; Male;

2004
Activation of serum aminotransferases by pyridoxal-5' -phosphate in epileptic patients treated with anticonvulsant drugs.
    Clinical biochemistry, 2004, Volume: 37, Issue:8

    Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Carbamazepine; Drug Therapy, Combination;

2004
Physical growth and endocrinal disorders during pubertal maturation in girls with epilepsy.
    Epilepsia, 2004, Volume: 45, Issue:9

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Dehydroepiandrosterone; Epilepsy; Female; Growth;

2004
Effects of piracetam alone and in combination with antiepileptic drugs in rodent seizure models.
    Journal of neural transmission (Vienna, Austria : 1996), 2004, Volume: 111, Issue:9

    Topics: Action Potentials; Animals; Anticonvulsants; Brain; Cobalt; Disease Models, Animal; Drug Combination

2004
Bioavailability of divalproex extended-release formulation relative to the divalproex delayed-release formulation.
    Biopharmaceutics & drug disposition, 2004, Volume: 25, Issue:8

    Topics: Anticonvulsants; Area Under Curve; Biological Availability; Chemistry, Pharmaceutical; Delayed-Actio

2004
Cognitive profile of topiramate as compared with lamotrigine in epilepsy patients on antiepileptic drug polytherapy: relationships to blood serum levels and comedication.
    Epilepsy & behavior : E&B, 2004, Volume: 5, Issue:5

    Topics: Adult; Anticonvulsants; Cognition; Drug Therapy, Combination; Epilepsy; Female; Fructose; Humans; La

2004
Clinical comparison of extended-release divalproex versus delayed-release divalproex: pooled data analyses from nine trials.
    Epilepsy & behavior : E&B, 2004, Volume: 5, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Child; Child, Preschool; Clinical Trial

2004
Navigating toward fetal and maternal health: the challenge of treating epilepsy in pregnancy.
    Epilepsia, 2004, Volume: 45, Issue:10

    Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Child; Cohort Studies; Confoundi

2004
Effect of carbamazepine and valproate on bone mineral density.
    Pediatric neurology, 2004, Volume: 31, Issue:4

    Topics: Adolescent; Anticonvulsants; Bone Density; Carbamazepine; Case-Control Studies; Child; Cross-Section

2004
The outcome of initiation of antiepileptic drug monotherapy in primary care: a UK database survey.
    The British journal of general practice : the journal of the Royal College of General Practitioners, 2004, Volume: 54, Issue:507

    Topics: Aged; Anticonvulsants; Carbamazepine; Child, Preschool; Clinical Competence; Epilepsy; Family Practi

2004
Assessment of the epilepsy treatment gap in two cities of south-east of Brazil.
    Arquivos de neuro-psiquiatria, 2004, Volume: 62, Issue:3B

    Topics: Adult; Anticonvulsants; Brazil; Carbamazepine; Epilepsy; Health Services Accessibility; Health Servi

2004
Longer term outcome of children born to mothers with epilepsy.
    Journal of neurology, neurosurgery, and psychiatry, 2004, Volume: 75, Issue:11

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Fema

2004
The longer term outcome of children born to mothers with epilepsy.
    Journal of neurology, neurosurgery, and psychiatry, 2004, Volume: 75, Issue:11

    Topics: Abnormalities, Drug-Induced; Adolescent; Anticonvulsants; Child; Child, Preschool; Cognition Disorde

2004
Fracture risk associated with use of antiepileptic drugs.
    Epilepsia, 2004, Volume: 45, Issue:11

    Topics: Adult; Anticonvulsants; Bone Density; Carbamazepine; Case-Control Studies; Denmark; Epilepsy; Female

2004
Australian pregnancy registry of women taking antiepileptic drugs.
    Epilepsia, 2004, Volume: 45, Issue:11

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Australia; Drug Therapy, Combination; Epilepsy; Female

2004
Critical relationship between sodium valproate dose and human teratogenicity: results of the Australian register of anti-epileptic drugs in pregnancy.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2004, Volume: 11, Issue:8

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Australia; Dose-Response Relationship, Drug; Epilepsy;

2004
Subregional changes in discharge rate, pattern, and drug sensitivity of putative GABAergic nigral neurons in the kindling model of epilepsy.
    The European journal of neuroscience, 2004, Volume: 20, Issue:9

    Topics: Action Potentials; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Female; gamma-Aminobu

2004
Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats.
    Journal of neural transmission (Vienna, Austria : 1996), 2005, Volume: 112, Issue:7

    Topics: Adrenergic Agents; Aminoglutethimide; Amygdala; Animals; Anticonvulsants; Clonazepam; Disease Models

2005
Valproic acid-induced pancreatitis in childhood epilepsy: case series and review.
    Journal of child neurology, 2004, Volume: 19, Issue:7

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diagnosis, Differential; Dose-Response Relatio

2004
Valproate-induced hyperammonemic encephalopathy: imaging findings on diffusion-weighted MRI.
    European neurology, 2004, Volume: 52, Issue:3

    Topics: Brain; Brain Mapping; Diffusion Magnetic Resonance Imaging; Epilepsy; Humans; Male; Middle Aged; Mul

2004
[Efficacy and safety of antiepileptic therapy in children (a comparative analysis of valproates and barbiturates)].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2004, Volume: 104, Issue:8

    Topics: Adolescent; Age Factors; Anticonvulsants; Barbiturates; Child; Child, Preschool; Electroencephalogra

2004
[Valproate-induced hyperammonemic encephalopathy in a patient with Sjögren's syndrome].
    Rinsho shinkeigaku = Clinical neurology, 2004, Volume: 44, Issue:10

    Topics: Anticonvulsants; Epilepsy; Female; Humans; Hyperammonemia; Magnetic Resonance Imaging; Middle Aged;

2004
Population pharmacokinetic model of valproate and prediction of valproate serum concentrations in children with epilepsy.
    Acta pharmacologica Sinica, 2004, Volume: 25, Issue:12

    Topics: Adolescent; Bayes Theorem; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Models,

2004
Influence of coadministered antiepileptic drugs on serum phenobarbital concentrations in epileptic patients: quantitative analysis based on a suitable transforming factor.
    Biological & pharmaceutical bulletin, 2004, Volume: 27, Issue:12

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Child; Chil

2004
[Influence of psychotropic drugs on thrombocytes aggregation in patients with epilepsy].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2004, Volume: 104, Issue:11

    Topics: Adolescent; Adult; Barbiturates; Carbamazepine; Epilepsy; Humans; In Vitro Techniques; Lamotrigine;

2004
Initiation of treatment and selection of antiepileptic drugs in childhood epilepsy.
    Epilepsia, 2004, Volume: 45 Suppl 8

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy;

2004
Effect of long-term therapy with sodium valproate on nail and serum trace element status in epileptic children.
    Biological trace element research, 2004,Winter, Volume: 102, Issue:1-3

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Copper; Epilepsy; Female; Humans; Infant; Male

2004
Valproic acid intoxication: sense and non-sense of haemodialysis.
    The Netherlands journal of medicine, 2004, Volume: 62, Issue:9

    Topics: Adult; Drug Overdose; Epilepsy; Ethanol; Hemodiafiltration; Hemoperfusion; Humans; Male; Mental Diso

2004
Efficacy and tolerability of the new antiepileptic drugs I: treatment of new onset epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epileps
    Neurology, 2005, Jan-11, Volume: 64, Issue:1

    Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; Fructose; Humans; Seizures; Topiramate; Valproi

2005
Bone mass and turnover in women with epilepsy on antiepileptic drug monotherapy.
    Annals of neurology, 2005, Volume: 57, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Bone and Bones; Bone Remodeling; Carbamazepine; Epilepsy; Female

2005
Antiepileptic drugs alter reproductive endocrine hormones in men with epilepsy.
    European journal of neurology, 2005, Volume: 12, Issue:2

    Topics: Adult; Age Factors; Androstenedione; Anticonvulsants; C-Peptide; Carbamazepine; Carnitine; Dihydrote

2005
Investigating heterogeneity in an individual patient data meta-analysis of time to event outcomes.
    Statistics in medicine, 2005, May-15, Volume: 24, Issue:9

    Topics: Anticonvulsants; Carbamazepine; Computer Simulation; Epilepsy; Genetic Heterogeneity; Humans; Meta-A

2005
Acute seizures due to a probable interaction between valproic acid and meropenem.
    The Annals of pharmacotherapy, 2005, Volume: 39, Issue:3

    Topics: Acute Disease; Adult; Anti-Bacterial Agents; Anticonvulsants; Drug Interactions; Epilepsy; Female; H

2005
Gingival enlargement in children treated with antiepileptics.
    Journal of child neurology, 2004, Volume: 19, Issue:12

    Topics: Anticonvulsants; Carbamazepine; Case-Control Studies; Child; Cross-Sectional Studies; Dental Plaque

2004
[Sjögren's syndrome with autonomic failure and epilepsy].
    La Revue de medecine interne, 2005, Volume: 26, Issue:2

    Topics: Aged; Anti-Inflammatory Agents; Anticonvulsants; Autonomic Nervous System Diseases; Electromyography

2005
Complex cardiac defect with hypoplastic right ventricle in a fetus with valproate exposure.
    Prenatal diagnosis, 2005, Volume: 25, Issue:2

    Topics: Abortion, Induced; Adult; Anticonvulsants; Diagnosis, Differential; Epilepsy; Female; Heart Defects,

2005
Autoimmune haemolytic anaemia and renal Fanconi syndrome caused by valproate therapy.
    European journal of pediatrics, 2005, Volume: 164, Issue:3

    Topics: Anemia, Hemolytic, Autoimmune; Anticonvulsants; Child, Preschool; Epilepsy; Fanconi Syndrome; Female

2005
Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice.
    Biological psychiatry, 2005, Mar-01, Volume: 57, Issue:5

    Topics: Aggression; Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Blotting, Western; Cell Adh

2005
Valproic acid induces differentiation of a supratentorial primitive neuroectodermal tumor.
    Pediatric hematology and oncology, 2004, Volume: 21, Issue:8

    Topics: Cell Differentiation; Cell Proliferation; Child; Epilepsy; Family Health; Humans; Male; Neuroectoder

2004
What can we say to women of reproductive age with epilepsy?
    Neurology, 2005, Mar-22, Volume: 64, Issue:6

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Dose-Response Relationship, Drug; E

2005
Neuropsychological effects of exposure to anticonvulsant medication in utero.
    Neurology, 2005, Mar-22, Volume: 64, Issue:6

    Topics: Adolescent; Anticonvulsants; Brain; Child; Cognition Disorders; Cohort Studies; Epilepsy; Female; Hu

2005
Increased rate of major malformations in offspring exposed to valproate during pregnancy.
    Neurology, 2005, Mar-22, Volume: 64, Issue:6

    Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Inte

2005
Valproate-induced eosinophilia in children with epilepsy: role of interleukin-5.
    Journal of child neurology, 2005, Volume: 20, Issue:2

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Case-Control Studies; Child; Child, Preschool; Eosinophi

2005
Topiramate-valproate-induced hyperammonemic encephalopathy syndrome: case report.
    Journal of child neurology, 2005, Volume: 20, Issue:2

    Topics: Adolescent; Anticonvulsants; Brain Diseases; Chromosome Inversion; Chromosomes, Human, Pair 15; Drug

2005
Acute leukemia associated with valproic acid treatment: a novel mechanism for leukemogenesis?
    American journal of hematology, 2005, Volume: 78, Issue:4

    Topics: Acute Disease; Adult; Anticonvulsants; Chromosome Aberrations; Chromosomes, Human, Pair 7; Chromosom

2005
Sodium valproate -- induced skeletal myopathy.
    Indian journal of pediatrics, 2005, Volume: 72, Issue:3

    Topics: Anticonvulsants; Carbamazepine; Carnitine; Child, Preschool; Epilepsy; Humans; Male; Muscular Diseas

2005
Valproate-induced proximal renal tubular dysfunction: clinically relevant in the severely disabled epileptic population.
    Epilepsia, 2005, Volume: 46, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Disabled Persons; Epilepsy; Fanconi Syndrome; Female; Humans; Ma

2005
Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptics.
    Neurology, 2005, Apr-12, Volume: 64, Issue:7

    Topics: Anticonvulsants; Carbamazepine; Causality; Epilepsy; Germany; Humans; Incidence; Inpatients; Lamotri

2005
Pharmacokinetic interaction on valproic acid and recurrence of epileptic seizures during chemotherapy in an epileptic patient.
    British journal of clinical pharmacology, 2005, Volume: 59, Issue:5

    Topics: Adult; Anticonvulsants; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cisplatin; Drug I

2005
Telogen effluvium caused by magnesium valproate and lamotrigine.
    Acta dermato-venereologica, 2005, Volume: 85, Issue:1

    Topics: Acute Disease; Adolescent; Adult; Alopecia; Anticonvulsants; Epilepsy; Female; Humans; Lamotrigine;

2005
Lack of pharmacokinetic interactions between steady-state zonisamide and valproic acid in patients with epilepsy.
    Clinical pharmacokinetics, 2005, Volume: 44, Issue:5

    Topics: Adult; Anticonvulsants; Drug Interactions; Epilepsy; Female; Humans; Isoxazoles; Male; Middle Aged;

2005
[The use of valproates-generics in the treatment of epileptic patients].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2005, Volume: 105, Issue:4

    Topics: Adult; Electroencephalography; Epilepsy; Female; Humans; Male; Quality of Life; Valproic Acid

2005
Motor impairment on awakening in a patient with an EEG pattern of "unilateral, continuous spikes and waves during slow sleep".
    Epileptic disorders : international epilepsy journal with videotape, 2005, Volume: 7, Issue:2

    Topics: Anticonvulsants; Arm; Benzodiazepines; Child; Clobazam; Electroencephalography; Epilepsy; Ethosuximi

2005
Blood homocysteine, folate and vitamin B-12 concentrations in patients with epilepsy receiving lamotrigine or sodium valproate for initial monotherapy.
    Epilepsy research, 2005, Volume: 64, Issue:3

    Topics: Adult; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Lamotrigine; Male; Middle Aged; Triazines

2005
Serum valproate levels with oral contraceptive use.
    Epilepsia, 2005, Volume: 46, Issue:6

    Topics: Adult; Anticonvulsants; Comorbidity; Contraceptives, Oral, Combined; Drug Combinations; Drug Interac

2005
Antiepileptic drug use of women with epilepsy and congenital malformations in offspring.
    Neurology, 2005, Jun-14, Volume: 64, Issue:11

    Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Cardiovascular Abnormalities; Cleft Palate; Coh

2005
Seizure worsening caused by decreased serum valproate during meropenem therapy.
    Journal of child neurology, 2005, Volume: 20, Issue:5

    Topics: Anti-Bacterial Agents; Anticonvulsants; Child; Drug Interactions; Epilepsy; Female; Humans; Meropene

2005
Lethal obesity associated with sodium valproate in a brain-injured patient.
    Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology, 2005, Volume: 18, Issue:2

    Topics: Adult; Anticonvulsants; Brain Injuries; Epilepsy; Fatal Outcome; Heart Failure; Humans; Male; Obesit

2005
Valproate-induced hyperammonemic encephalopathy with normal liver function.
    Neurology India, 2005, Volume: 53, Issue:2

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Epilepsy; Female; Humans; Liver; Liver Function Tests; Mal

2005
A comparative study of the effect of carbamazepine and valproic acid on the pharmacokinetics and metabolic profile of topiramate at steady state in patients with epilepsy.
    Epilepsia, 2005, Volume: 46, Issue:7

    Topics: Adult; Anticonvulsants; Biological Availability; Carbamazepine; Dose-Response Relationship, Drug; Dr

2005
Fit for a fracture.
    The Medical journal of Australia, 2005, Aug-15, Volume: 183, Issue:4

    Topics: Anticonvulsants; Epilepsy; Ergocalciferols; Female; Femoral Neck Fractures; Follow-Up Studies; Fract

2005
Maternal valproate dosage and foetal malformations.
    Acta neurologica Scandinavica, 2005, Volume: 112, Issue:3

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Logistic Models; Pregnancy;

2005
[Hyperammonemia secondary to the use of valproic acid: case report].
    Arquivos de neuro-psiquiatria, 2005, Volume: 63, Issue:2A

    Topics: Anticonvulsants; Child; Epilepsy; Humans; Hyperammonemia; Male; Valproic Acid

2005
Pharmacokinetic interactions of carbamazepine with some antiepileptic drugs during epilepsy treatment in children and adolescents.
    Roczniki Akademii Medycznej w Bialymstoku (1995), 2005, Volume: 50 Suppl 1

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Drug Interactions; Epilepsy; Female; Fructose; Hu

2005
Weight change in monozygotic twins treated with valproate.
    Obesity research, 2005, Volume: 13, Issue:8

    Topics: Adolescent; Adult; Anticonvulsants; Child, Preschool; Diseases in Twins; Epilepsy; Female; Humans; M

2005
Treatment with valproic acid for myelofibrosis with myeloid metaplasia.
    Annals of hematology, 2005, Volume: 84, Issue:12

    Topics: Aged; Anticonvulsants; Blood Cell Count; Epilepsy; Female; Hemorrhage; Humans; Primary Myelofibrosis

2005
[Determination of sodium valproate in serum by gas chromatography].
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2004, Volume: 29, Issue:5

    Topics: Anticonvulsants; Chromatography, High Pressure Liquid; Epilepsy; Humans; Valproic Acid

2004
Valproate-induced bleeding: report of two cases and review of literature.
    Indian pediatrics, 2005, Volume: 42, Issue:8

    Topics: Adolescent; Anticonvulsants; Child; Epilepsy; Epilepsy, Absence; Factor XII Deficiency; Female; Hemo

2005
Preclinical profiling and safety studies of ABT-769: a compound with potential for broad-spectrum antiepileptic activity.
    Epilepsia, 2005, Volume: 46, Issue:9

    Topics: Abnormalities, Drug-Induced; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Disease Models, A

2005
Safety and tolerability of the ketogenic diet in pediatric epilepsy: effects of valproate combination therapy.
    Epilepsia, 2005, Volume: 46, Issue:9

    Topics: Acidosis; Anticonvulsants; Child; Child, Preschool; Combined Modality Therapy; Dietary Fats; Epileps

2005
Lamotrigine associated with exacerbation or de novo myoclonus in idiopathic generalized epilepsies.
    Neurology, 2005, Sep-13, Volume: 65, Issue:5

    Topics: Adult; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Epilepsie

2005
Dysmorphic features: an important clue to the diagnosis and severity of fetal anticonvulsant syndromes.
    Archives of disease in childhood. Fetal and neonatal edition, 2006, Volume: 91, Issue:2

    Topics: Abnormalities, Drug-Induced; Adolescent; Anthropometry; Anticonvulsants; Carbamazepine; Child; Child

2006
Epilepsy and medication effects on the pattern visual evoked potential.
    Documenta ophthalmologica. Advances in ophthalmology, 2005, Volume: 110, Issue:1

    Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Evoked Potentials, Visual; Female; Follow-Up Studie

2005
[Effect of carbamazepine and valproate on bone metabolism in children with epilepsy].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2005, Volume: 43, Issue:10

    Topics: Amino Acids; Anticonvulsants; Bone and Bones; Bone Density; Calcium, Dietary; Carbamazepine; Child;

2005
Improvement of oligoasthenozoospermia in epileptic patients on switching anti-epilepsy medication from sodium valproate to phenytoin.
    Scandinavian journal of urology and nephrology, 2005, Volume: 39, Issue:5

    Topics: Adult; Anticonvulsants; Epilepsy; Follow-Up Studies; Humans; Male; Oligospermia; Phenytoin; Sperm Co

2005
[Anticonvulsive pharmacotherapy may aggravate epilepsy course].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2005, Volume: 105, Issue:10

    Topics: Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Electroencephalography; Epilepsy;

2005
Acute hyperammonemic coma with chronic valproic acid therapy.
    The Annals of pharmacotherapy, 2005, Volume: 39, Issue:12

    Topics: Anticonvulsants; Coma; Electroencephalography; Epilepsy; Female; Humans; Hyperammonemia; Middle Aged

2005
[The efficacy of topiramate (topamax) in the treatment of resistant epilepsy in children].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2005, Volume: 105, Issue:11

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Resistance; Drug Therapy,

2005
The use of lamotrigine and other antiepileptic drugs in paediatric patients at a Malaysian hospital.
    Pharmacy world & science : PWS, 2005, Volume: 27, Issue:5

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cost-Benefit Analysis; D

2005
Leptin, ghrelin, and adiponectin in epileptic patients treated with valproic acid.
    Neurology, 2005, Dec-13, Volume: 65, Issue:11

    Topics: Adiponectin; Adipose Tissue; Adolescent; Adult; Anticonvulsants; Appetite Regulation; Body Weight; B

2005
Valproate-induced insulin resistance in prepubertal girls with epilepsy.
    Journal of pediatric endocrinology & metabolism : JPEM, 2005, Volume: 18, Issue:10

    Topics: Adolescent; Androstenedione; Anticonvulsants; Blood Glucose; Body Mass Index; Child; Cross-Sectional

2005
Possible precipitation of myoclonic seizures with oxcarbazepine.
    Epilepsy & behavior : E&B, 2006, Volume: 8, Issue:1

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsy; Female; Humans; Infant

2006
Management of epilepsy in adults. Diagnosis guidelines.
    Postgraduate medicine, 2005, Volume: 118, Issue:6

    Topics: Adolescent; Adult; Algorithms; Anticonvulsants; Child; Diagnosis, Differential; Electroencephalograp

2005
Frequency of epileptiform EEG abnormalities in a sequential screening of autistic patients with no known clinical epilepsy from 1996 to 2005.
    Epilepsy & behavior : E&B, 2006, Volume: 8, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Autistic Disorder; Child; Child, Preschool; Electroencephalograp

2006
Effects of common anti-epileptic drug monotherapy on serum levels of homocysteine, vitamin B12, folic acid and vitamin B6.
    Seizure, 2006, Volume: 15, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Epilepsy; Female; Folic Aci

2006
Parkinsonism and/or cognitive impairment with valproic acid therapy: a report of ten cases.
    Pharmacopsychiatry, 2006, Volume: 39, Issue:1

    Topics: Aged; Anticonvulsants; Cognition Disorders; Epilepsy; Female; Humans; Male; Middle Aged; Parkinsonia

2006
Chrono impact versus enteric coated valproate in Thai epileptic patients.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2005, Volume: 88, Issue:11

    Topics: Adult; Aged; Anticonvulsants; Delayed-Action Preparations; Epilepsy; Female; Humans; Male; Middle Ag

2005
Screening for bipolar disorder in women with polycystic ovary syndrome: a pilot study.
    Journal of affective disorders, 2006, Volume: 91, Issue:2-3

    Topics: Adolescent; Adult; Anticonvulsants; Bipolar Disorder; Epilepsy; Female; Humans; Mass Screening; Midd

2006
Lack of association between the C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment.
    Epilepsia, 2006, Volume: 47, Issue:2

    Topics: Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug Interactions; Drug Th

2006
Detecting vigabatrin toxicity by imaging of the retinal nerve fiber layer.
    Investigative ophthalmology & visual science, 2006, Volume: 47, Issue:3

    Topics: Adult; Anticonvulsants; Carbamazepine; Cross-Sectional Studies; Epilepsy; Female; Humans; Male; Nerv

2006
[Ergenyl chronospheres in juvenile and senile epilepsies].
    Krankenpflege Journal, 2005, Volume: 43, Issue:7-10

    Topics: Adolescent; Age Factors; Aged; Child; Chronotherapy; Controlled Clinical Trials as Topic; Delayed-Ac

2005
CACNA1A mutation in a EA-2 patient responsive to acetazolamide and valproic acid.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2006, Volume: 33, Issue:1

    Topics: Acetazolamide; Adult; Amino Acid Sequence; Animals; Anticonvulsants; Calcium Channels; Diagnosis, Di

2006
Insulin-related metabolic changes during treatment with valproate in patients with epilepsy.
    Epilepsy & behavior : E&B, 2006, Volume: 8, Issue:3

    Topics: Adult; Anticonvulsants; Body Mass Index; Epilepsy; Female; Humans; Hyperinsulinism; Insulin; Lipopro

2006
Effect of intracerebroventricular continuous infusion of valproic acid versus single i.p. and i.c.v. injections in the amygdala kindling epilepsy model.
    Epilepsy research, 2006, Volume: 70, Issue:1

    Topics: Amygdala; Animals; Anticonvulsants; Cerebral Ventricles; Disease Models, Animal; Dose-Response Relat

2006
Retinal nerve fiber layer and macular thickness in adolescents with epilepsy treated with valproate and carbamazepine.
    Epilepsia, 2006, Volume: 47, Issue:4

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Color Vision Defects; Epilepsy; Female; Follow-Up

2006
Predicted plasma valproic acid concentrations in patients missing and replacing a full daily dose of extended-release divalproex sodium.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2006, May-15, Volume: 63, Issue:10

    Topics: Anticonvulsants; Delayed-Action Preparations; Epilepsy; Forecasting; Humans; Patient Compliance; Val

2006
A case of fetal anticonvulsant syndrome with severe bilateral upper limb defect.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2006, Volume: 19, Issue:2

    Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fetal Diseases

2006
[Polycystic ovary syndrome and hepatocellular adenoma related to long-term use of sodium valproate in a young woman].
    No to hattatsu = Brain and development, 2006, Volume: 38, Issue:3

    Topics: Adenoma, Liver Cell; Adult; Epilepsy; Female; Humans; Hyperandrogenism; Liver Neoplasms; Polycystic

2006
Serum total amylase, pancreatic amylase and lipase activities in epileptic children treated with sodium valproate monotherapy.
    Brain & development, 2006, Volume: 28, Issue:9

    Topics: Adolescent; Amylases; Anticonvulsants; Child; Child, Preschool; Clinical Enzyme Tests; Epilepsy; Fem

2006
The influence of old age and enzyme inducing comedication on the pharmacokinetics of valproic acid at steady-state: A case-matched evaluation based on therapeutic drug monitoring data.
    Epilepsy research, 2006, Volume: 70, Issue:2-3

    Topics: Adult; Aged; Aging; Anticonvulsants; Case-Control Studies; Dose-Response Relationship, Drug; Drug In

2006
Antiepileptic drug use and birth rate in patients with epilepsy--a population-based cohort study in Finland.
    Human reproduction (Oxford, England), 2006, Volume: 21, Issue:9

    Topics: Adolescent; Adult; Anticonvulsants; Birth Rate; Carbamazepine; Cohort Studies; Epilepsy; Female; Fin

2006
[Investigation of efficacy of convulex-retard in epilepsy treatment].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2006, Volume: 106, Issue:5

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Delayed-Action Preparations; Dose-Response Relationship, D

2006
Excitability of the human epileptic cortex after chronic valproate: a reappraisal.
    Brain research, 2006, Jul-12, Volume: 1099, Issue:1

    Topics: Adolescent; Adult; Analysis of Variance; Anticonvulsants; Cerebral Cortex; Drug Administration Sched

2006
Does it really matter when a blood sample for valproic acid concentration is taken following once-daily administration of divalproex-ER?
    Therapeutic drug monitoring, 2006, Volume: 28, Issue:3

    Topics: Anticonvulsants; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Administration

2006
Valproic acid, an antiepileptic drug with histone deacetylase inhibitory activity, potentiates the cytotoxic effect of Apo2L/TRAIL on cultured thoracic cancer cells through mitochondria-dependent caspase activation.
    Neoplasia (New York, N.Y.), 2006, Volume: 8, Issue:6

    Topics: Apoptosis; Apoptosis Regulatory Proteins; Carcinoma, Non-Small-Cell Lung; Caspases; Cell Line, Tumor

2006
Protein C, protein S and other pro- and anticoagulant activities among epileptic children using sodium valproate.
    Brain & development, 2006, Volume: 28, Issue:9

    Topics: Adolescent; Anticoagulants; Anticonvulsants; Blood Cell Count; Case-Control Studies; Child; Child, P

2006
Effect of delayed and/or missed enteric-coated divalproex doses on valproic acid concentrations: simulation and dose replacement recommendations for the clinician.
    Journal of clinical pharmacy and therapeutics, 2006, Volume: 31, Issue:4

    Topics: Adult; Anticonvulsants; Computer Simulation; Delayed-Action Preparations; Drug Administration Schedu

2006
Epileptic seizures caused by low valproic acid levels from an interaction with meropenem.
    Journal of clinical pharmacy and therapeutics, 2006, Volume: 31, Issue:4

    Topics: Anticonvulsants; Drug Interactions; Epilepsy; Female; Humans; Meropenem; Middle Aged; Pneumonia; Thi

2006
Valproate-associated coagulopathies are frequent and variable in children.
    Epilepsia, 2006, Volume: 47, Issue:7

    Topics: Age Factors; Anticonvulsants; Blood Coagulation Tests; Child; Coagulation Protein Disorders; Epileps

2006
Early effect of sodium valproate and carbamazepine monotherapy on homocysteine metabolism in children with epilepsy.
    Epilepsy research, 2006, Volume: 71, Issue:2-3

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Folic Acid; H

2006
Adverse effects of antiepileptic drugs on bone mineral density.
    Pediatric neurology, 2006, Volume: 35, Issue:3

    Topics: Adolescent; Anticonvulsants; Bone Density; Calcification, Physiologic; Carbamazepine; Case-Control S

2006
Characterization of insulin secretion in Valproate-treated patients with epilepsy.
    Epilepsia, 2006, Volume: 47, Issue:9

    Topics: Adult; Anticonvulsants; Blood Glucose; C-Peptide; Epilepsy; Fasting; Female; Humans; Hyperinsulinism

2006
Increased apparent oral clearance of valproic acid during intake of combined contraceptive steroids in women with epilepsy.
    Epilepsia, 2006, Volume: 47, Issue:9

    Topics: Administration, Oral; Adolescent; Adult; Anticonvulsants; Contraceptives, Oral, Combined; Contracept

2006
Idiopathic hypereosinophilic syndrome complicated by central sinovenous thrombosis.
    Brain & development, 2007, Volume: 29, Issue:3

    Topics: Anticoagulants; Anticonvulsants; Cerebral Hemorrhage; Child; DNA Mutational Analysis; Epilepsy; Huma

2007
Capillary microscopy and hemorheology in children during antiepileptic monotherapy with carbamazepine and valproate.
    Seizure, 2006, Volume: 15, Issue:8

    Topics: Adolescent; Anticonvulsants; Blood Flow Velocity; Capillaries; Carbamazepine; Cerebellar Cortex; Chi

2006
Movement disorders in patients taking anticonvulsants.
    Journal of neurology, neurosurgery, and psychiatry, 2007, Volume: 78, Issue:2

    Topics: Adult; Aged; Anticonvulsants; Cross-Sectional Studies; Epilepsy; Female; Humans; Male; Middle Aged;

2007
The effects of valproate exposure in utero on behavior and the need for educational support in school-aged children.
    Epilepsy & behavior : E&B, 2006, Volume: 9, Issue:4

    Topics: Anticonvulsants; Carbamazepine; Child; Cognition; Education, Special; Epilepsy; Female; Humans; Ment

2006
Autonomic headache with autonomic seizures: a case report.
    The journal of headache and pain, 2006, Volume: 7, Issue:5

    Topics: Anticonvulsants; Autonomic Nervous System; Diagnosis, Differential; Electroencephalography; Epilepsy

2006
Oral rapid loading of valproic acid--an alternative to the usual saturation scheme?
    Seizure, 2006, Volume: 15, Issue:8

    Topics: Administration, Oral; Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; T

2006
Oxidative stress in children receiving valproic acid.
    The Journal of pediatrics, 2006, Volume: 149, Issue:5

    Topics: Adolescent; Age Factors; Anticonvulsants; Benzodiazepines; Biomarkers; Canada; Carbamazepine; Case-C

2006
Reproductive endocrine function in women with epilepsy: the role of epilepsy type and medication.
    Epilepsy & behavior : E&B, 2007, Volume: 10, Issue:1

    Topics: Adolescent; Adult; Analysis of Variance; Anticonvulsants; Epilepsy; Female; Humans; Hyperandrogenism

2007
Brain pseudoatrophy and mental regression on valproate and a mitochondrial DNA mutation.
    Neurology, 2006, Nov-14, Volume: 67, Issue:9

    Topics: Adult; Aged; Anticonvulsants; Atrophy; Brain; Child; Cognition Disorders; Developmental Disabilities

2006
Valproate-induced Parkinsonism in epilepsy patients.
    Movement disorders : official journal of the Movement Disorder Society, 2007, Volume: 22, Issue:1

    Topics: Adult; Anticonvulsants; Chi-Square Distribution; Epilepsy; Female; Humans; Male; Middle Aged; Parkin

2007
The evaluation of thyroid functions, thyroid antibodies, and thyroid volumes in children with epilepsy during short-term administration of oxcarbazepine and valproate.
    Epilepsia, 2006, Volume: 47, Issue:11

    Topics: Antibodies; Anticonvulsants; Carbamazepine; Child; Drug Administration Schedule; Epilepsy; Humans; I

2006
How to replace lamotrigine with valproate.
    Epilepsia, 2006, Volume: 47, Issue:11

    Topics: Adolescent; Adult; Anticonvulsants; Cost-Benefit Analysis; Dose-Response Relationship, Drug; Drug Ad

2006
Plasma vitamin values and antiepileptic therapy: case reports of pregnancy outcomes affected by a neural tube defect.
    Birth defects research. Part A, Clinical and molecular teratology, 2007, Volume: 79, Issue:1

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Folic Acid; Genetic Predisposition to Disease; Homocystein

2007
Serum lipid profile in children receiving anti-epileptic drug monotherapy: is it atherogenic?
    Journal of pediatric endocrinology & metabolism : JPEM, 2006, Volume: 19, Issue:9

    Topics: Adolescent; Anticonvulsants; Apolipoproteins; Atherosclerosis; Carbamazepine; Child; Cholesterol, HD

2006
The effects of carbamazepine, valproic acid and phenobarbital on the oxidative and antioxidative balance in epileptic children.
    European neurology, 2007, Volume: 57, Issue:2

    Topics: Anticonvulsants; Antioxidants; Bilirubin; Carbamazepine; Child; Child, Preschool; Epilepsy; Female;

2007
[Determination of serum valproic acid drugs by capillary electrophoresis].
    Klinicheskaia laboratornaia diagnostika, 2006, Issue:11

    Topics: Anticonvulsants; Electrophoresis, Capillary; Epilepsy; Humans; Sensitivity and Specificity; Valproic

2006
The challenges of psychopharmacological management of children with severe developmental disabilities.
    Journal of child and adolescent psychopharmacology, 2006, Volume: 16, Issue:6

    Topics: Anticonvulsants; Antipsychotic Agents; Autistic Disorder; Caregivers; Child; Developmental Disabilit

2006
Valproic acid-induced hepatopathy: nine new fatalities in Germany from 1994 to 2003.
    Epilepsia, 2006, Volume: 47, Issue:12

    Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Chemical and Drug Induced Liver Injury; Child; Chil

2006
The frequency of reversible parkinsonism and cognitive decline associated with valproate treatment: a study of 364 patients with different types of epilepsy.
    Epilepsia, 2006, Volume: 47, Issue:12

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Cognition Disorders; Drug Administration Schedule; Drug Th

2006
Distinct absorption characteristics of oral formulations of valproic acid/divalproex available in the United States.
    Epilepsy research, 2007, Volume: 73, Issue:3

    Topics: Absorption; Administration, Oral; Anticonvulsants; Area Under Curve; Drug Combinations; Drug Compoun

2007
Valproate, weight gain and carbohydrate craving: a gender study.
    Seizure, 2007, Volume: 16, Issue:3

    Topics: Adult; Anticonvulsants; Appetite; Body Mass Index; Dietary Carbohydrates; Epilepsy; Female; Glucose;

2007
A 6-month longitudinal study of bone mineral density with antiepileptic drug monotherapy.
    Epilepsy & behavior : E&B, 2007, Volume: 10, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Biomarkers; Bone Density; Bone Diseases, Metabolic; Calcitriol;

2007
Valproic acid aggravates epilepsy due to MELAS in a patient with an A3243G mutation of mitochondrial DNA.
    Metabolic brain disease, 2007, Volume: 22, Issue:1

    Topics: Adult; Anticonvulsants; DNA, Mitochondrial; Electroencephalography; Epilepsy; Humans; Magnetic Reson

2007
[Valproate sodium and zonisamide associated interstitial pneumonitis in an infant].
    No to hattatsu = Brain and development, 2007, Volume: 39, Issue:1

    Topics: Anticonvulsants; Epilepsy; Female; Humans; Infant; Isoxazoles; Lung Diseases, Interstitial; Respirat

2007
Effects of valproate on acylcarnitines in children with epilepsy using ESI-MS/MS.
    Epilepsia, 2007, Volume: 48, Issue:1

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Carnitine; Chemical and Drug Induced Liver Injury; Child

2007
Valproate-associated coagulopathies are frequent and variable in children.
    Epilepsia, 2007, Volume: 48, Issue:1

    Topics: Age Factors; Ambulatory Care; Anticonvulsants; Blood Coagulation Disorders; Child; Epilepsy; Female;

2007
Effects of valproic acid on hearing in epileptic patients.
    International journal of pediatric otorhinolaryngology, 2007, Volume: 71, Issue:4

    Topics: Adolescent; Anticonvulsants; Audiometry; Auditory Threshold; Case-Control Studies; Child; Drug Admin

2007
Population estimation of the effects of cytochrome P450 2C9 and 2C19 polymorphisms on phenobarbital clearance in Japanese.
    Therapeutic drug monitoring, 2007, Volume: 29, Issue:1

    Topics: Adult; Algorithms; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Asian People; Cytochrome P-450 CY

2007
A peculiar form of epilepsy induced by crying in infancy.
    Brain & development, 2007, Volume: 29, Issue:8

    Topics: Anticonvulsants; Crying; Electroencephalography; Epilepsy; Humans; Infant; Respiration; Valproic Aci

2007
[An association between the FABP2 gene polymorphism and efficacy of valproates].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2007, Volume: 107, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alleles; Anticonvulsants; Biological Transport, Active;

2007
Endocrine effects of valproate in adolescent girls with epilepsy.
    Epilepsia, 2007, Volume: 48, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Body Height; Body Mass Index; Child; Comorbidity; Epilepsy; Fema

2007
Is valproate encephalopathy under-recognised in older people? A case series.
    Age and ageing, 2007, Volume: 36, Issue:3

    Topics: Aged; Aged, 80 and over; Anticonvulsants; Diagnosis, Differential; Electroencephalography; Epilepsy;

2007
A survey of antiepileptic prescribing to women of childbearing potential in psychiatry.
    Archives of women's mental health, 2007, Volume: 10, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Prescriptions; England; Epilepsy; Female; Ho

2007
Antiepileptic drugs prevent changes induced by pilocarpine model of epilepsy in brain ecto-nucleotidases.
    Neurochemical research, 2007, Volume: 32, Issue:6

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphatases; Adenosine Triphosphate; A

2007
Different clinical manifestations of hyperammonemic encephalopathy.
    Epilepsy & behavior : E&B, 2007, Volume: 10, Issue:4

    Topics: Adult; Anticonvulsants; Brain Diseases, Metabolic; Drug Therapy, Combination; Electroencephalography

2007
Valproate is an effective, well-tolerated drug for treatment of status epilepticus/serial attacks in adults.
    Acta neurologica Scandinavica. Supplementum, 2007, Volume: 187

    Topics: Adult; Aged; Aged, 80 and over; Anesthetics, General; Anticonvulsants; Dose-Response Relationship, D

2007
Stevens-Johnson syndrome due to concomitant use of lamotrigine and valproic acid.
    American journal of clinical dermatology, 2007, Volume: 8, Issue:2

    Topics: Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Lamotrig

2007
Sodium valproate, hyperandrogenism and altered ovarian function in Indian women with epilepsy: a prospective study.
    Epilepsia, 2007, Volume: 48, Issue:7

    Topics: Body Mass Index; Epilepsy; Female; Follow-Up Studies; Hirsutism; Humans; Hyperandrogenism; Indians,

2007
The effect of sodium valproate on proton MRS visible neurochemical concentrations.
    Epilepsy research, 2007, Volume: 74, Issue:2-3

    Topics: Adolescent; Adult; Algorithms; Anticonvulsants; Brain Chemistry; Dipeptides; Epilepsy; Female; Gluta

2007
[Long latency auditory evoked potentials in schoolchildren and adolescents with epilepsy].
    Przeglad lekarski, 2006, Volume: 63 Suppl 1

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Case-Control Studies; Child; Cognition; Epilepsy; Event-

2006
[Nocturnal epilepsy associated with sleep apnea syndrome].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2007, Apr-10, Volume: 96, Issue:4

    Topics: Circadian Rhythm; Epilepsy; Humans; Intermittent Positive-Pressure Ventilation; Male; Middle Aged; P

2007
Temporal lobe epilepsy is a disease of faulty neuronal resonators rather than oscillators, and all seizures are provoked, usually by stress.
    Medical hypotheses, 2007, Volume: 69, Issue:6

    Topics: Anticonvulsants; Epilepsy; Epilepsy, Temporal Lobe; Ethosuximide; Hippocampus; Humans; Models, Neuro

2007
[Clinical observation of valproate sodium-induced nocturnal enuresis].
    No to hattatsu = Brain and development, 2007, Volume: 39, Issue:3

    Topics: Adult; Anticonvulsants; Child; Epilepsy; Female; Humans; Male; Nocturnal Enuresis; Valproic Acid

2007
Video-EEG in syncopal attack due to ocular compression in an adolescent mistreated for epilepsy.
    Epileptic disorders : international epilepsy journal with videotape, 2007, Volume: 9, Issue:2

    Topics: Adolescent; Cerebral Cortex; Diagnosis, Differential; Diagnostic Errors; Electroencephalography; Epi

2007
Phenytoin but not valproate directly affected in vitro trophoblast differentiation.
    European journal of obstetrics, gynecology, and reproductive biology, 2008, Volume: 137, Issue:1

    Topics: Anticonvulsants; Cell Differentiation; Cells, Cultured; Dose-Response Relationship, Drug; Epilepsy;

2008
Metabolic and hormonal disturbances in women with epilepsy on antiepileptic drug monotherapy.
    Epilepsia, 2007, Volume: 48, Issue:7

    Topics: Adolescent; Adult; Anticonvulsants; Blood Glucose; Body Mass Index; Carbamazepine; Comorbidity; Epil

2007
Motor correlates of models of secondary bilateral synchrony and multiple epileptic foci.
    Seizure, 2007, Volume: 16, Issue:7

    Topics: Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Convulsants; Data Interpretation, Statistic

2007
Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshock.
    Epilepsy & behavior : E&B, 2007, Volume: 11, Issue:1

    Topics: Acetamides; Algorithms; Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease

2007
Severe bleeding complications during antiepileptic treatment with valproic acid in children.
    Neuropediatrics, 2007, Volume: 38, Issue:1

    Topics: Adolescent; Anticonvulsants; Blood Platelet Disorders; Child, Preschool; Epilepsy; Humans; Infant; I

2007
Risk factors for development of subclinical hypothyroidism during valproic acid therapy.
    The Journal of pediatrics, 2007, Volume: 151, Issue:2

    Topics: Adolescent; Age Distribution; Case-Control Studies; Child; Child, Preschool; Cohort Studies; Dose-Re

2007
Visual field defect during therapy with valproic-acid.
    European journal of neurology, 2007, Volume: 14, Issue:8

    Topics: Adult; Epilepsy; Female; GABA Agents; gamma-Aminobutyric Acid; Humans; Retina; Retinal Degeneration;

2007
Old versus new antiepileptic drugs: the SANAD study.
    Lancet (London, England), 2007, Jul-28, Volume: 370, Issue:9584

    Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Lamotrigine; Triazines; Valproic Acid

2007
Early intervention for the ocular and neurodevelopmental sequelae of Fetal Valproate Syndrome.
    Journal of paediatrics and child health, 2007, Volume: 43, Issue:9

    Topics: Abnormalities, Drug-Induced; Amblyopia; Anticonvulsants; Autistic Disorder; Child, Preschool; Cranio

2007
Multiple system atrophy due to prolonged valproic acid treatment.
    International psychogeriatrics, 2007, Volume: 19, Issue:4

    Topics: Anticonvulsants; Brain; Epilepsy; Female; Humans; Magnetic Resonance Imaging; Middle Aged; Multiple

2007
Conversion to lamotrigine monotherapy from valproate monotherapy in older adolescent patients with epilepsy.
    Current medical research and opinion, 2007, Volume: 23, Issue:10

    Topics: Adolescent; Adult; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Lamo

2007
Population pharmacokinetics of valproate in Chinese children with epilepsy.
    Acta pharmacologica Sinica, 2007, Volume: 28, Issue:10

    Topics: Adolescent; Anticonvulsants; Bayes Theorem; Child; Child, Preschool; China; Epilepsy; Female; Humans

2007
Population pharmacokinetics of valproic acid concentrations in elderly nursing home residents.
    Therapeutic drug monitoring, 2007, Volume: 29, Issue:5

    Topics: Aged; Aged, 80 and over; Anticonvulsants; Drug Monitoring; Epilepsy; Female; Health Services for the

2007
Prescribing patterns of antiepileptic drugs in Italy: a nationwide population-based study in the years 2000-2005.
    European journal of neurology, 2007, Volume: 14, Issue:12

    Topics: Adolescent; Adult; Age Distribution; Aged; Amines; Anticonvulsants; Carbamazepine; Catchment Area, H

2007
[Effect of UGT1A6 genetic polymorphisms on the metabolism of sodium valproate].
    Zhonghua yi xue za zhi, 2007, Aug-07, Volume: 87, Issue:29

    Topics: Adolescent; Adult; Base Sequence; Child; Child, Preschool; Epilepsy; Gene Frequency; Genotype; Glucu

2007
Which patients become seizure free with antiepileptic drugs? An observational study in 821 patients with epilepsy.
    Acta neurologica Scandinavica, 2008, Volume: 117, Issue:1

    Topics: Adult; Anticonvulsants; Carbamazepine; Cohort Studies; Drug Resistance; Drug Therapy, Combination; E

2008
Can prolonged administration of valproic acid put patients with epilepsy at higher risk for development of Alzheimer's disease?
    Epilepsy & behavior : E&B, 2008, Volume: 12, Issue:1

    Topics: Alzheimer Disease; Anticonvulsants; Epilepsy; Humans; Valproic Acid

2008
The Australian Register of Antiepileptic Drugs in Pregnancy: the first 1002 pregnancies.
    The Australian & New Zealand journal of obstetrics & gynaecology, 2007, Volume: 47, Issue:6

    Topics: Anticonvulsants; Australia; Birth Weight; Epilepsy; Female; Fetus; Humans; Pregnancy; Pregnancy Comp

2007
Serum sodium valproate testing: is it appropriate?
    The Medical journal of Australia, 2007, Nov-19, Volume: 187, Issue:10

    Topics: Epilepsy; Evidence-Based Medicine; Female; Humans; Male; Medical Audit; Retrospective Studies; Valpr

2007
Adiponectin and visfatin concentrations in children treated with valproic acid.
    Epilepsia, 2008, Volume: 49, Issue:2

    Topics: Adiponectin; Adipose Tissue; Age Factors; Anticonvulsants; Blood Glucose; Child; Epilepsy; Female; H

2008
Encephalopathy induced by levetiracetam added to valproate.
    Acta neurologica Scandinavica, 2008, Volume: 117, Issue:5

    Topics: Adult; Anticonvulsants; Brain Diseases; Electroencephalography; Epilepsy; Humans; Levetiracetam; Mal

2008
Massive valproic acid overdose, a misleading case.
    The American journal of emergency medicine, 2008, Volume: 26, Issue:1

    Topics: Adult; Ammonia; Anticonvulsants; Antidotes; Charcoal; Coma; Drug Overdose; Epilepsy; Humans; Male; P

2008
[Seven cases of decreased serum valproic acid concentration during concomitant use of carbapenem antibiotics].
    The Korean journal of laboratory medicine, 2007, Volume: 27, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anticonvulsants; Carbapenems; Drug Interactio

2007
Treatment of refractory seizures due to a benign mass present in the corpus callosum with an ion magnetic inductor: case report.
    Brain tumor pathology, 2005, Volume: 22, Issue:2

    Topics: Adult; Agenesis of Corpus Callosum; Anticonvulsants; Colchicine; Combined Modality Therapy; Corpus C

2005
Glutathione-S-transferase (GST) M1 null genotype and combined GSTM1 and GSTT1 null genotypes are risk factors for increased serum gamma-glutamyltransferase in valproic acid-treated patients.
    Clinica chimica acta; international journal of clinical chemistry, 2008, Volume: 389, Issue:1-2

    Topics: Adolescent; Adult; Anticonvulsants; Child; Epilepsy; Female; gamma-Glutamyltransferase; Genotype; Gl

2008
The measurement of ammonia blood levels in patients taking valproic acid: looking for problems where they do not exist?
    Epilepsy & behavior : E&B, 2008, Volume: 12, Issue:3

    Topics: Ammonia; Anticonvulsants; Epilepsy; Humans; Valproic Acid

2008
Mixed models for ordinal data: a pharmacokinetic study on the effectiveness of drug for the reduction of epileptic seizures.
    Statistics in medicine, 2008, Aug-15, Volume: 27, Issue:18

    Topics: Anticonvulsants; Epilepsy; Humans; Models, Statistical; Monte Carlo Method; Treatment Outcome; Valpr

2008
Homocysteine levels in epileptic children receiving antiepileptic drugs.
    Journal of child neurology, 2007, Volume: 22, Issue:12

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Folic Acid; Homocysteine; Human

2007
Pharmacokinetic modeling of valproate from clinical data in Serbian epileptic patients.
    Methods and findings in experimental and clinical pharmacology, 2007, Volume: 29, Issue:10

    Topics: Adolescent; Adult; Age Factors; Algorithms; Anticonvulsants; Biological Availability; Carbamazepine;

2007
Reversible valproate hepatotoxicity due to mutations in mitochondrial DNA polymerase gamma (POLG1).
    Archives of disease in childhood, 2008, Volume: 93, Issue:2

    Topics: Anticonvulsants; Child, Preschool; DNA Polymerase gamma; DNA-Directed DNA Polymerase; DNA, Mitochond

2008
Characterization of non-linear relationship between total and unbound serum concentrations of valproic acid in epileptic children.
    Journal of clinical pharmacy and therapeutics, 2008, Volume: 33, Issue:1

    Topics: Adolescent; Anticonvulsants; Binding Sites; Child; Child, Preschool; Drug Interactions; Drug Monitor

2008
Evaluation of the relationship between C677T variants of methylenetetrahydrofolate reductase gene and hyperhomocysteinemia in children receiving antiepileptic drug therapy.
    Progress in neuro-psychopharmacology & biological psychiatry, 2008, Apr-01, Volume: 32, Issue:3

    Topics: Adolescent; Analysis of Variance; Anticonvulsants; Carbamazepine; Child; Chromatography, High Pressu

2008
Contraindications to phenytoin in emergency department patients with seizures.
    The Journal of emergency medicine, 2009, Volume: 37, Issue:4

    Topics: Anticonvulsants; Contraindications; Emergency Service, Hospital; Epilepsy; Female; Humans; Levetirac

2009
Simultaneous toxicities in a child on multiple anticonvulsants.
    Journal of child neurology, 2008, Volume: 23, Issue:9

    Topics: Anticonvulsants; Bone Marrow; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Child, P

2008
Treatment of newly diagnosed epilepsies: the shortcomings of SANAD.
    Developmental medicine and child neurology, 2008, Volume: 50, Issue:4

    Topics: Anticonvulsants; Carbamazepine; Child; Epilepsy; Follow-Up Studies; Humans; Lamotrigine; Randomized

2008
Loss of astrocytic domain organization in the epileptic brain.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, Mar-26, Volume: 28, Issue:13

    Topics: Amino Acids; Amyloid beta-Protein Precursor; Animals; Anticonvulsants; Astrocytes; Basic Helix-Loop-

2008
[Study of oro-dental injuries during seizures in Senegalese children with epilepsy].
    Odonto-stomatologie tropicale = Tropical dental journal, 2007, Volume: 30, Issue:120

    Topics: Accidental Falls; Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Ma

2007
[Depakine in the therapy of epilepsy in children and adolescents].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2007, Volume: 107, Issue:8

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Drug; Electroencep

2007
[Visual auras in idiopathic generalized epilepsy].
    Revue neurologique, 2008, Volume: 164, Issue:3

    Topics: Adolescent; Anticonvulsants; Behavior; Electroencephalography; Epilepsy; Epilepsy, Generalized; Epil

2008
Neuronal peroxisome proliferator-activated receptor gamma signaling: regulation by mood-stabilizer valproate.
    Journal of molecular neuroscience : MN, 2008, Volume: 35, Issue:2

    Topics: Acyl-CoA Oxidase; Animals; Antimanic Agents; Bipolar Disorder; Catalase; Epilepsy; Gene Expression;

2008
Bone health in young women with epilepsy after one year of antiepileptic drug monotherapy.
    Neurology, 2008, Apr-29, Volume: 70, Issue:18

    Topics: Adolescent; Adult; Alkaline Phosphatase; Anticonvulsants; Biomarkers; Bone Density; Bone Diseases, M

2008
Fish liver oil and propolis as protective natural products against the effect of the anti-epileptic drug valproate on immunological markers of bone formation in rats.
    Epilepsy research, 2008, Volume: 80, Issue:1

    Topics: Alkaline Phosphatase; Animals; Anticonvulsants; Atropine; Biomarkers; Bone Resorption; Disease Model

2008
[The use of generic valparin xr in the treatment of epilepsy.].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2007, Volume: 107, Issue:10

    Topics: Anticonvulsants; Drug Therapy, Combination; Epilepsy; Humans; Seizures; Treatment Outcome; Valproic

2007
Risk of hypospadias in newborn infants exposed to valproic acid during the first trimester of pregnancy: a case-control study in Spain.
    Drug safety, 2008, Volume: 31, Issue:6

    Topics: Anticonvulsants; Case-Control Studies; Epilepsy; Female; Humans; Hypospadias; Infant, Newborn; Logis

2008
Our work is still cut out for us...
    Epileptic disorders : international epilepsy journal with videotape, 2008, Volume: 10, Issue:1

    Topics: Anticonvulsants; Carbamazepine; Child; Data Collection; Epilepsy; Expert Testimony; Guidelines as To

2008
Inverse correlation of valproic acid serum concentrations and quality of life in adolescents with epilepsy.
    Epilepsy research, 2008, Volume: 80, Issue:2-3

    Topics: Adolescent; Adult; Anticonvulsants; Child; Epilepsy; Female; Humans; Male; Quality of Life; Statisti

2008
Valproic acid during pregnancy.
    Lancet (London, England), 1980, Apr-19, Volume: 1, Issue:8173

    Topics: Epilepsy; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complications; Valproic Acid

1980
Secondary hyperammonaemia: a possible mechanism for valproate encephalopathy.
    Lancet (London, England), 1980, Jun-14, Volume: 1, Issue:8181

    Topics: Ammonia; Brain; Brain Diseases; Child, Preschool; Epilepsy; Female; Humans; Propionates; Valproic Ac

1980
Psychiatric implications of anticonvulsant drugs.
    The Journal of clinical psychiatry, 1980, Volume: 41, Issue:9

    Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Dose-Response Relationship, Dr

1980
Acute liver disease associated with sodium valproate.
    Lancet (London, England), 1980, Nov-22, Volume: 2, Issue:8204

    Topics: Acute Disease; Adult; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Epilepsy; Fat

1980
Sodium valproate and the liver.
    Lancet (London, England), 1980, Nov-22, Volume: 2, Issue:8204

    Topics: Chemical and Drug Induced Liver Injury; Child; Epilepsy; Humans; Liver; Liver Diseases; Valproic Aci

1980
Diurnal fluctuation of serum level of sodium valproate and interaction with neuroleptics.
    Folia psychiatrica et neurologica japonica, 1980, Volume: 34, Issue:3

    Topics: Adolescent; Adult; Antipsychotic Agents; Circadian Rhythm; Drug Interactions; Epilepsy; Female; Huma

1980
Drug safety in porphyria: risks of valproate and metoclopramide.
    Lancet (London, England), 1981, Jul-11, Volume: 2, Issue:8237

    Topics: Adolescent; Epilepsy; Female; Humans; Metoclopramide; Porphyrias; Valproic Acid

1981
Choice of anticonvulsants in epilepsy.
    Indian pediatrics, 1981, Volume: 18, Issue:5

    Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Child, Preschool

1981
New anticonvulsant drugs.
    Monographs in neural sciences, 1980, Volume: 5

    Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Epilepsy; gamma-Aminobutyric A

1980
Co-trimoxazole prophylaxis in leukaemia.
    Lancet (London, England), 1982, Feb-20, Volume: 1, Issue:8269

    Topics: Child; Drug Combinations; Drug Synergism; Epilepsy; Humans; Leukemia, Lymphoid; Sulfamethoxazole; Tr

1982
Valproate levels in children with epilepsy.
    Lancet (London, England), 1982, Mar-20, Volume: 1, Issue:8273

    Topics: Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Valproic Acid

1982
Maternal valproic acid and congenital neural tube defects.
    Lancet (London, England), 1982, Oct-23, Volume: 2, Issue:8304

    Topics: Epilepsy; Female; Humans; Maternal-Fetal Exchange; Neural Tube Defects; Pregnancy; Valproic Acid

1982
Valproic acid and spina bifida.
    Lancet (London, England), 1982, Nov-13, Volume: 2, Issue:8307

    Topics: Epilepsy; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; Pregn

1982
Valproate and malformations.
    Lancet (London, England), 1982, Dec-11, Volume: 2, Issue:8311

    Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pre

1982
[The effect of valproate monotherapy on the activities of liver enzymes in epileptic children and adolescents].
    Der Nervenarzt, 1982, Volume: 53, Issue:12

    Topics: Adolescent; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Child; Enzymes;

1982
The influence of antiepileptic drugs on the electroencephalogram: a review of controlled clinical studies.
    Electroencephalography and clinical neurophysiology. Supplement, 1982, Volume: 36

    Topics: Anti-Anxiety Agents; Anticonvulsants; Brain; Carbamazepine; Clonazepam; Electroencephalography; Epil

1982
[Rise in gamma-GT during anticonvulsive therapy].
    Wiener klinische Wochenschrift, 1982, Nov-12, Volume: 94, Issue:21

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combinatio

1982
Valproic acid and spina bifida.
    Lancet (London, England), 1983, Sep-17, Volume: 2, Issue:8351

    Topics: Adult; Anencephaly; Epilepsy; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complications; S

1983
Possible hazard of valpromide-carbamazepine combination therapy in epilepsy.
    Lancet (London, England), 1984, Apr-07, Volume: 1, Issue:8380

    Topics: Anticonvulsants; Carbamazepine; Drug Synergism; Drug Therapy, Combination; Epilepsy; Humans; Valproi

1984
Pharmacokinetics of antiepileptic drugs.
    Acta neurologica Scandinavica. Supplementum, 1983, Volume: 97

    Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Child, Preschool

1983
Hepatitis A in three patients taking sodium valproate.
    Lancet (London, England), 1984, Apr-28, Volume: 1, Issue:8383

    Topics: Adult; Child; Epilepsy; Female; Hepatitis A; Humans; Liver; Valproic Acid

1984
Pharmacodynamic factors in the occurrence of psychiatric symptoms among patients with epilepsy.
    Folia psychiatrica et neurologica japonica, 1983, Volume: 37, Issue:3

    Topics: Anticonvulsants; Barbiturates; Carbamazepine; Epilepsy; Folic Acid; Humans; Kinetics; Mental Disorde

1983
Valproic acid increases gamma-aminobutyric acid in CSF of epileptic children.
    Lancet (London, England), 1984, Jul-28, Volume: 2, Issue:8396

    Topics: Animals; Brain; Child; Epilepsy; gamma-Aminobutyric Acid; Humans; Valproic Acid

1984
Spina bifida and in-utero exposure to valproate.
    Lancet (London, England), 1984, Aug-18, Volume: 2, Issue:8399

    Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complications; Spina Bif

1984
Valproate and spina bifida.
    Lancet (London, England), 1984, Dec-15, Volume: 2, Issue:8416

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Epilepsy; Female; Humans; Middle Aged; Pregnancy; Pr

1984
Electroencephalographic and behavioural effects of sodium valproate in patients with photosensitive epilepsy. A single dose trial.
    Journal of neurology, 1980, Volume: 224, Issue:2

    Topics: Adolescent; Adult; Child; Epilepsy; Evoked Potentials; Female; Humans; Light; Male; Valproic Acid

1980
Plasma concentrations of valproate during maintenance therapy in epileptic children.
    Journal of neurology, 1982, Volume: 228, Issue:2

    Topics: Adolescent; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Epilepsy, A

1982
[Monotherapy with sodium valproate in generalized primary epilepsy. 2d phase: Study of long-term efficacy and tolerance].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1983, Apr-21, Volume: 59, Issue:16

    Topics: Adult; Amylases; Body Weight; Drug Tolerance; Epilepsy; Female; Humans; Male; Middle Aged; Pregnancy

1983
Plasma arginine vasopressin concentrations in epileptics under monotherapy.
    Journal of neurology, 1983, Volume: 230, Issue:3

    Topics: Adult; Anticonvulsants; Arginine Vasopressin; Carbamazepine; Epilepsy; Humans; Phenytoin; Primidone;

1983
Pattern-reversal visual evoked potentials in photosensitive epilepsy.
    Electroencephalography and clinical neurophysiology, 1984, Volume: 59, Issue:2

    Topics: Adolescent; Adult; Epilepsy; Evoked Potentials, Visual; Female; Form Perception; Humans; Light; Male

1984
Sodium valproate and corticotropin suppression in the child treated for seizures.
    The Journal of pediatrics, 1983, Volume: 102, Issue:1

    Topics: Adrenocorticotropic Hormone; Adult; Child; Epilepsy; Humans; Hydrocortisone; Valproic Acid

1983
Valproic acid and fetal abnormality.
    British medical journal (Clinical research ed.), 1983, Jan-15, Volume: 286, Issue:6360

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Epilepsy; Female; Humans; Infant, Newbo

1983
[Biochemical aspects of pathophysiology and treatment of intractable epilepsy in children].
    No to hattatsu = Brain and development, 1983, Volume: 15, Issue:2

    Topics: Adrenocorticotropic Hormone; Animals; Child; Child, Preschool; Epilepsy; Humans; Indoles; Male; Pyri

1983
The treatable epilepsies.
    The New England journal of medicine, 1983, Dec-08, Volume: 309, Issue:23

    Topics: Adrenocorticotropic Hormone; Child; Epilepsy; Humans; Phenytoin; Spasms, Infantile; Valproic Acid

1983
Valproic acid and metabolites: pharmacological and toxicological studies.
    Epilepsia, 1984, Volume: 25 Suppl 1

    Topics: Abnormalities, Drug-Induced; Animals; Brain; Chemical and Drug Induced Liver Injury; Chemical Phenom

1984
Valproate: recent findings and perspectives.
    Epilepsia, 1984, Volume: 25 Suppl 1

    Topics: Chemical Phenomena; Chemistry; Epilepsy; gamma-Aminobutyric Acid; Humans; Ion Channels; Membrane Pot

1984
Valproic acid: update on its mechanisms of action.
    Epilepsia, 1984, Volume: 25 Suppl 1

    Topics: Brain; Drug Synergism; Epilepsy; gamma-Aminobutyric Acid; Humans; Ion Channels; Membrane Potentials;

1984
Valproic acid and intractable seizures in severely brain-damaged patients.
    Neurology, 1983, Volume: 33, Issue:1

    Topics: Adolescent; Adult; Brain Damage, Chronic; Child; Epilepsy; Female; Humans; Male; Middle Aged; Valpro

1983
Hazard of video games in patients with light-sensitive epilepsy.
    JAMA, 1983, Feb-11, Volume: 249, Issue:6

    Topics: Adolescent; Electroencephalography; Epilepsy; Humans; Light; Male; Photic Stimulation; Play and Play

1983
[Sodium valproate: a hyperammonemic drug. Study in the epileptic and healthy volunteer].
    Journal of the neurological sciences, 1983, Volume: 58, Issue:2

    Topics: Ammonia; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination;

1983
Spina bifida and sodium valproate.
    The Medical journal of Australia, 1983, Apr-30, Volume: 1, Issue:9

    Topics: Epilepsy; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complications; Spina Bifida Occulta;

1983
The effect of chronic anticonvulsant therapy on serum lipids and lipoproteins in epileptic children.
    Neurology, 1983, Volume: 33, Issue:4

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cholesterol; Epilepsy; Humans;

1983
[Spina bifida caused by valproic acid?].
    Nederlands tijdschrift voor geneeskunde, 1983, Mar-12, Volume: 127, Issue:11

    Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complic

1983
Carbamazepine and valproic acid.
    Research publications - Association for Research in Nervous and Mental Disease, 1983, Volume: 61

    Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug In

1983
Transplacental passage and half-life of sodium valproate in infants born to epileptic mothers.
    British journal of clinical pharmacology, 1983, Volume: 15, Issue:4

    Topics: Epilepsy; Female; Fetal Blood; Half-Life; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pregnanc

1983
Serum thyroid hormones and blood folic acid during monotherapy with carbamazepine or valproate. A controlled study.
    Acta neurologica Scandinavica, 1983, Volume: 67, Issue:4

    Topics: Adolescent; Adult; Aged; Carbamazepine; Epilepsy; Folic Acid; Humans; Middle Aged; Thyroid Hormones;

1983
Free and bound valproic acid separated by two methods of ultrafiltration.
    Clinical chemistry, 1983, Volume: 29, Issue:7

    Topics: Epilepsy; Humans; Immunoenzyme Techniques; Ultrafiltration; Valproic Acid

1983
The effects of peritoneal dialysis on the single dose and steady state pharmacokinetics of valproic acid in a uremic epileptic child.
    European journal of clinical pharmacology, 1983, Volume: 24, Issue:3

    Topics: Child; Epilepsy; Half-Life; Humans; Kinetics; Peritoneal Dialysis; Uremia; Valproic Acid

1983
[Ataractic treatment in psychiatry and general medicine. 2. Tranquillant = tranquilizers = daytime sedatives].
    Fortschritte der Medizin, 1983, Jun-02, Volume: 101, Issue:21

    Topics: Anticonvulsants; Antidepressive Agents; Benzodiazepines; Carbamazepine; Chemistry, Pharmaceutical; C

1983
Oral state of children with epilepsy on treatment with sodium valproate.
    Scandinavian journal of dental research, 1983, Volume: 91, Issue:3

    Topics: Adolescent; Child; Dental Plaque; Epilepsy; Gingivitis; Humans; Mouth Diseases; Oral Hygiene; Valpro

1983
Diurnal fluctuations in free and total plasma concentrations of valproic acid at steady state in epileptic patients.
    Therapeutic drug monitoring, 1983, Volume: 5, Issue:2

    Topics: Adolescent; Adult; Child; Circadian Rhythm; Dose-Response Relationship, Drug; Drug Therapy, Combinat

1983
Valproic acid free fraction in epileptic children under chronic monotherapy.
    Therapeutic drug monitoring, 1983, Volume: 5, Issue:2

    Topics: Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Time Factors; Valproic Acid

1983
Treatment of epilepsy in women of child-bearing age: patients' opinion of teratogenic potential of valproate.
    Acta neurologica Scandinavica. Supplementum, 1983, Volume: 94

    Topics: Adolescent; Adult; Attitude; Drug Therapy, Combination; Epilepsy; Female; Humans; Infant, Newborn; M

1983
Antiepileptic drugs and teratogenesis. How should patients, doctors and health authorities be counselled?
    Acta neurologica Scandinavica. Supplementum, 1983, Volume: 94

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant, Newbo

1983
Active metabolites in antiepileptic therapy. Reflections on a pharmacological joker.
    Acta neurologica Scandinavica. Supplementum, 1983, Volume: 94

    Topics: Anticonvulsants; Biotransformation; Carbamazepine; Diazepam; Epilepsy; Humans; Kinetics; Primidone;

1983
Intoxication with sodium valproate. A case report.
    Acta medica Scandinavica, 1983, Volume: 213, Issue:5

    Topics: Adolescent; Bilirubin; Epilepsy; Female; Humans; Valproic Acid

1983
[Case of congenital anomalies born to an epileptic woman treated with valproic acid and phenobarbital].
    No to hattatsu = Brain and development, 1983, Volume: 15, Issue:3

    Topics: Abnormalities, Drug-Induced; Ear, External; Epilepsy; Esotropia; Female; Humans; Infant; Phenobarbit

1983
Drugs for epilepsy.
    The Medical letter on drugs and therapeutics, 1983, Sep-02, Volume: 25, Issue:643

    Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy; Humans; Phenobarbital; Phenytoin; Statu

1983
Chronic valproate administration reduces fasting ketonemia in children.
    Neurology, 1983, Volume: 33, Issue:10

    Topics: Child; Child, Preschool; Epilepsy; Fasting; Humans; Hydroxybutyrates; Ketone Bodies; Liver Glycogen;

1983
[Is valproic acid teratogenic?].
    Revue neurologique, 1983, Volume: 139, Issue:6-7

    Topics: Abnormalities, Drug-Induced; Adult; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Infa

1983
Twice-daily dosing of valproate with divalproex.
    Clinical pharmacology and therapeutics, 1983, Volume: 34, Issue:4

    Topics: Absorption; Adolescent; Adult; Child; Delayed-Action Preparations; Drug Evaluation; Epilepsy; Female

1983
Value of Mongolian gerbils in antiepileptic drug evaluation.
    Epilepsia, 1983, Volume: 24, Issue:5

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation; Epilepsy; Gerbillinae; Seizures;

1983
Sodium valproate associated with phenobarbital: effects on ammonia metabolism in humans.
    Epilepsia, 1983, Volume: 24, Issue:5

    Topics: Adult; Ammonia; Epilepsy; Female; Humans; Kidney; Liver; Male; Middle Aged; Phenobarbital; Valproic

1983
Treatment of the nonconvulsive epilepsies.
    Epilepsia, 1983, Volume: 24 Suppl 1

    Topics: Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Humans; Phenobarbi

1983
Intra-daily oscillations in dipropylacetic acid plasma levels with two or three daily doses of dipropylacetamide in epileptic patients.
    Italian journal of neurological sciences, 1983, Volume: 4, Issue:2

    Topics: Adolescent; Adult; Child; Circadian Rhythm; Drug Administration Schedule; Epilepsy; Female; Humans;

1983
Possible teratogenic effect of valproate during pregnancy.
    The Journal of pediatrics, 1983, Volume: 103, Issue:6

    Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pre

1983
Valproate-induced hyperammonemia in asymptomatic children.
    Cleveland Clinic quarterly, 1983,Fall, Volume: 50, Issue:3

    Topics: Adolescent; Adult; Ammonia; Child; Child, Preschool; Epilepsy; Humans; Infant; Liver; Valproic Acid

1983
[Pharmacotherapy of epilepsy--current problems and controversies].
    Fortschritte der Neurologie-Psychiatrie, 1983, Volume: 51, Issue:11

    Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; Epilepsy,

1983
Treatment of epileptic patients with valproic acid does not modify plasma and urine short-chain-fatty acids.
    Acta neurologica Scandinavica, 1983, Volume: 68, Issue:4

    Topics: Adolescent; Adult; Ammonia; Brain Diseases; Butyrates; Epilepsy; Fatty Acids; Female; Hemiterpenes;

1983
[Correlation among sodium valproate concentrations in the total blood, plasma ultrafiltrate, and cerebrospinal fluid].
    No to hattatsu = Brain and development, 1983, Volume: 15, Issue:5

    Topics: Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Valproic Acid

1983
Should we routinely measure free plasma phenytoin concentration?
    British journal of clinical pharmacology, 1984, Volume: 17, Issue:1

    Topics: Adolescent; Adult; Aged; Blood Proteins; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Pro

1984
Sodium valproate re epilepsy.
    The Journal of pediatrics, 1984, Volume: 104, Issue:2

    Topics: Child; Epilepsy; Humans; Hydrocortisone; Valproic Acid

1984
[Role of hyperammonemia in stuporous states induced by sodium valproate].
    Revue neurologique, 1983, Volume: 139, Issue:12

    Topics: Adult; Ammonia; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Female; Glutamine; Humans; U

1983
Unnecessary polypharmacy in patients with frequent seizures.
    Acta neurologica Scandinavica, 1984, Volume: 69, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Drug Therapy, Combination; Epi

1984
Intensive follow-up monitoring in patients with once daily evening administration of sodium valproate.
    Epilepsia, 1984, Volume: 25, Issue:2

    Topics: Adolescent; Adult; Child; Drug Administration Schedule; Electroencephalography; Epilepsy; Female; Hu

1984
Protein binding of valproic acid in maternal and umbilical cord serum.
    Epilepsia, 1984, Volume: 25, Issue:2

    Topics: Adolescent; Adult; Blood Proteins; Epilepsy; Female; Fetal Blood; Humans; Pregnancy; Pregnancy Compl

1984
Valproic acid in the perinatal period: decreased maternal serum protein binding results in fetal accumulation and neonatal displacement of the drug and some metabolites.
    The Journal of pediatrics, 1984, Volume: 104, Issue:4

    Topics: Blood Proteins; Epilepsy; Fatty Acids, Nonesterified; Female; Fetal Blood; Fetus; Humans; Infant, Ne

1984
Pharmacokinetics of enteric-coated valproic acid.
    Therapeutic drug monitoring, 1984, Volume: 6, Issue:1

    Topics: Adult; Biological Availability; Capsules; Epilepsy; Female; Humans; Kinetics; Male; Tablets, Enteric

1984
Side effects of carbamazepine, valproate and clonazepam during long-term treatment of epilepsy.
    Acta neurologica Scandinavica. Supplementum, 1983, Volume: 97

    Topics: Abnormalities, Drug-Induced; Arousal; Benzodiazepinones; Carbamazepine; Chemical and Drug Induced Li

1983
Hepatic toxicity of antiepileptic drugs: a review.
    Acta neurologica Scandinavica. Supplementum, 1983, Volume: 97

    Topics: Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury; Energy Metabolism; Epilepsy;

1983
[Platelet dysfunction in children during treatment with sodium valproate].
    No to hattatsu = Brain and development, 1984, Volume: 16, Issue:1

    Topics: Adolescent; Age Factors; Blood Platelets; Child; Child, Preschool; Epilepsy; Female; Humans; Male; P

1984
Open trials with valproate in epilepsy.
    Epilepsia, 1984, Volume: 25 Suppl 1

    Topics: Drug Therapy; Epilepsies, Myoclonic; Epilepsy; Epilepsy, Temporal Lobe; Humans; Valproic Acid

1984
Non-dose-related side effects of valproate.
    Epilepsia, 1984, Volume: 25 Suppl 1

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Aged; Child; Child, Preschool; Epilepsy; Fat Necrosi

1984
Sodium valproate and cognitive function.
    Epilepsia, 1984, Volume: 25 Suppl 1

    Topics: Adolescent; Adult; Child; Cognition; Epilepsy; Humans; Psychological Tests; Valproic Acid

1984
Rational use of valproate: indications and drug regimen in epilepsy.
    Epilepsia, 1984, Volume: 25 Suppl 1

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Child,

1984
Valproate monotherapy.
    Epilepsia, 1984, Volume: 25 Suppl 1

    Topics: Anticonvulsants; Drug Therapy; Epilepsy; Humans; Valproic Acid

1984
Valproic acid and congenital malformations. A case report.
    Clinical pediatrics, 1984, Volume: 23, Issue:6

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Epilepsy; Female; Humans; Infant, Newbo

1984
Carbamazepine/valproic acid interaction in man and rhesus monkey.
    Epilepsia, 1984, Volume: 25, Issue:3

    Topics: Adolescent; Adult; Animals; Carbamazepine; Child; Dose-Response Relationship, Drug; Drug Interaction

1984
Hyperammonemia and valproate-induced alterations of the state of consciousness. A report of 8 cases.
    European neurology, 1984, Volume: 23, Issue:2

    Topics: Adult; Ammonia; Epilepsy; Female; Humans; Male; Unconsciousness; Valproic Acid

1984
Effect of anticonvulsant drugs on thalamo-cortical and hippocampo-cortical self-sustained after-discharges in the rat.
    Physiologia Bohemoslovaca, 1984, Volume: 33, Issue:2

    Topics: Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Electric Stimulation; Electroencephalograp

1984
Comparative evaluation of anticonvulsant and toxic potencies of valproic acid and 2-en-valproic acid in different animal models of epilepsy.
    European journal of pharmacology, 1984, Mar-23, Volume: 99, Issue:2-3

    Topics: Animals; Anticonvulsants; Electroshock; Epilepsy; Fatty Acids, Monounsaturated; Fatty Acids, Unsatur

1984
Five doubly unsaturated metabolites of valproic acid in urine and plasma of patients on valproic acid therapy.
    Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie, 1984, Volume: 22, Issue:4

    Topics: Epilepsy; Fatty Acids, Unsaturated; Gas Chromatography-Mass Spectrometry; Humans; Valproic Acid

1984
Lack of significant correlation between circadian profiles of valproic acid serum levels and epileptiform electroencephalographic activity.
    Therapeutic drug monitoring, 1984, Volume: 6, Issue:2

    Topics: Adolescent; Adult; Circadian Rhythm; Electroencephalography; Epilepsy; Female; Humans; Male; Middle

1984
The effects of carbamazepine and valproate on folate metabolism in man.
    Acta neurologica Scandinavica, 1984, Volume: 69, Issue:4

    Topics: Adolescent; Adult; Carbamazepine; Epilepsy; Female; Folic Acid; gamma-Glutamyl Hydrolase; Humans; In

1984
Potentiation of the anticonvulsant effects of antiepileptic drugs by "nootropics"; a potential new therapeutic approach.
    Acta neurologica Scandinavica. Supplementum, 1984, Volume: 99

    Topics: Animals; Anticonvulsants; Carbamazepine; Clonazepam; Dose-Response Relationship, Drug; Drug Synergis

1984
Summing up of the success so far gained through choice of drugs or combinations of drugs.
    Acta neurologica Scandinavica. Supplementum, 1984, Volume: 99

    Topics: Adult; Anticonvulsants; Carbamazepine; Cognition Disorders; Drug Therapy, Combination; Epilepsy; Hum

1984
Effect of valproate on free plasma phenytoin concentrations.
    British journal of clinical pharmacology, 1984, Volume: 18, Issue:1

    Topics: Adult; Binding, Competitive; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Protein Binding

1984
[The incidence of postoperative epilepsy and prophylactic anticonvulsants in patients with intracranial aneurysm].
    No shinkei geka. Neurological surgery, 1984, Volume: 12, Issue:3 Suppl

    Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; In

1984
Valproate treatment and carnitine deficiency.
    Neurology, 1984, Volume: 34, Issue:8

    Topics: Animals; Carnitine; Epilepsy; Liver; Muridae; Valproic Acid

1984
Rectal administration of sodium valproate in children.
    Italian journal of neurological sciences, 1984, Volume: 5, Issue:2

    Topics: Administration, Oral; Age Factors; Catheterization; Child; Child, Preschool; Epilepsy; Half-Life; Hu

1984
Nonsedative regimens in the treatment of epilepsy.
    Archives of internal medicine, 1983, Volume: 143, Issue:5

    Topics: Carbamazepine; Epilepsy; Ethosuximide; Humans; Phenytoin; Seizures; Valproic Acid

1983
Weight gain during treatment with valproate.
    Acta neurologica Scandinavica, 1984, Volume: 70, Issue:2

    Topics: Adult; Aged; Body Weight; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Middle Aged; Va

1984
Sodium valproate and routine liver function tests.
    Archives of disease in childhood, 1984, Volume: 59, Issue:9

    Topics: Chemical and Drug Induced Liver Injury; Child; Epilepsy; Humans; Liver Diseases; Liver Function Test

1984
A comparative study of the relative enzyme inducing properties of anticonvulsant drugs in epileptic patients.
    British journal of clinical pharmacology, 1984, Volume: 18, Issue:3

    Topics: Anticonvulsants; Antipyrine; Carbamazepine; Enzyme Induction; Epilepsy; Female; Glucaric Acid; Half-

1984
Acute changes of blood ammonia may predict short-term adverse effects of valproic acid.
    Neurology, 1984, Volume: 34, Issue:11

    Topics: Adolescent; Adult; Ammonia; Child; Consciousness Disorders; Epilepsy; Female; Humans; Male; Middle A

1984
[Plasma levels of antiepileptic agents in the treatment of epilepsy].
    Arquivos de neuro-psiquiatria, 1984, Volume: 42, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Drug Interac

1984
[Combination therapy with carbamazepine and valproic acid in problem cases at an outpatient epilepsy clinic].
    Arzneimittel-Forschung, 1984, Volume: 34, Issue:8

    Topics: Adult; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsy; Female;

1984
Electrically elicited seizures from the inferior colliculus: a potential site for the genesis of epilepsy?
    Experimental neurology, 1984, Volume: 86, Issue:3

    Topics: Animals; Chlordiazepoxide; Electric Stimulation; Electrophysiology; Epilepsy; Inferior Colliculi; Ma

1984
The fetal valproate syndrome.
    American journal of medical genetics, 1984, Volume: 19, Issue:3

    Topics: Epilepsy; Face; Female; Heart Defects, Congenital; Humans; Infant, Low Birth Weight; Infant, Newborn

1984
Steady-state valproate pharmacokinetics during long term therapy.
    Clinical and experimental neurology, 1983, Volume: 19

    Topics: Adolescent; Adult; Biological Availability; Child; Epilepsy; Half-Life; Humans; Kinetics; Metabolic

1983
Anticonvulsant effects on the memory performance of epileptics.
    Clinical and experimental neurology, 1984, Volume: 20

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Intelligence; Memory; Memory Di

1984
Anticonvulsants, folic acid and memory dysfunction in epileptics.
    Clinical and experimental neurology, 1984, Volume: 20

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Erythrocytes; Folic Acid; Humans; Memor

1984
Sodium valproate in the treatment of childhood epilepsies.
    Indian pediatrics, 1984, Volume: 21, Issue:6

    Topics: Child; Child, Preschool; Electroencephalography; Epilepsy; Humans; Infant; Infant, Newborn; Spasms,

1984
Clinical implications of serum protein binding in epileptic children during sodium valproate maintenance therapy.
    Therapeutic drug monitoring, 1984, Volume: 6, Issue:4

    Topics: Adult; Blood Proteins; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Kinetics; Male; Pr

1984
Free valproic acid: steady-state pharmacokinetics in patients with intractable epilepsy.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1984, Volume: 11, Issue:4

    Topics: Adolescent; Adult; Child; Child, Preschool; Epilepsy; Female; Humans; Kinetics; Male; Metabolic Clea

1984
Altered ratio of carbamazepine-10,11-epoxide/carbamazepine in plasma of children: evidence of anticonvulsant drug interaction.
    Developmental medicine and child neurology, 1984, Volume: 26, Issue:6

    Topics: Anticonvulsants; Carbamazepine; Child; Chromatography, Gas; Chromatography, High Pressure Liquid; Dr

1984
Correlation between plasma carbamazepine-10,11-epoxide concentration and drug side-effects in children with epilepsy.
    Developmental medicine and child neurology, 1984, Volume: 26, Issue:6

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Epil

1984
[Use of valproic acid in pregnancy: an indication for prenatal diagnosis of spina bifida].
    Nederlands tijdschrift voor geneeskunde, 1984, Dec-29, Volume: 128, Issue:52

    Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complic

1984
[Use of valproic acid by pregnant women with epilepsy and the risk of congenital abnormalities in the child].
    Nederlands tijdschrift voor geneeskunde, 1984, Dec-29, Volume: 128, Issue:52

    Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complic

1984
Venous blood ammonia concentrations in adult epileptic patients are increased by treatment with valproic acid.
    Acta neurologica, 1984, Volume: 6, Issue:6

    Topics: Adult; Ammonia; Epilepsy; Female; Humans; Male; Middle Aged; Valproic Acid

1984
Sodium valproate and platelet counts.
    British medical journal, 1980, Jan-19, Volume: 280, Issue:6208

    Topics: Epilepsy; Humans; Platelet Count; Thrombocytopenia; Valproic Acid

1980
Dipropylacetate and aminoaciduria.
    Journal of the neurological sciences, 1980, Volume: 45, Issue:1

    Topics: Adolescent; Adult; Amino Acids; Child; Child, Preschool; Epilepsy; Humans; Middle Aged; Renal Aminoa

1980
[Anticonvulsive combined therapy (author's transl)].
    Wiener klinische Wochenschrift, 1980, Jan-04, Volume: 92, Issue:1

    Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epileps

1980
Once-daily sodium valproate in the treatment of epilepsy.
    Developmental medicine and child neurology, 1980, Volume: 22, Issue:2

    Topics: Adolescent; Adult; Child; Drug Administration Schedule; Epilepsy; Humans; Valproic Acid

1980
Prophylaxis against febrile convulsions.
    British medical journal, 1980, Apr-19, Volume: 280, Issue:6221

    Topics: Child, Preschool; Diagnosis, Differential; Epilepsy; Humans; Infant; Phenobarbital; Seizures; Seizur

1980
The effect of chronic N-dipropylacetamide ("depamide") treatment on plasmatic immunoglobulins of epileptic patients.
    Acta neurologica, 1980, Volume: 2, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Child; Epilepsy; Female; Humans; Immunoglobulin A; Immunoglobuli

1980
[Autoallergic drug exanthemas].
    Fortschritte der Medizin, 1980, May-22, Volume: 98, Issue:19

    Topics: Autoimmune Diseases; Child; Epilepsy; Female; Humans; Lupus Erythematosus, Systemic; Male; Pemphigus

1980
Clinical experience with sodium valproate in children.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1980, May-24, Volume: 57, Issue:21

    Topics: Adolescent; Child; Child, Preschool; Drug Evaluation; Epilepsies, Myoclonic; Epilepsy; Epilepsy, Abs

1980
Sodium valproate and acute hepatic failure.
    Developmental medicine and child neurology, 1980, Volume: 22, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Child; Drug Therapy, Combination; Epilepsy; Humans; Valproic

1980
A rapid and simple gas-liquid chromatographic determination of valproic acid (alpha-propyl-valeric acid) in serum.
    Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie, 1980, Volume: 18, Issue:8

    Topics: Epilepsy; Flame Ionization; Humans; Valproic Acid

1980
[Severe liver damage following administration of valproic acid (Depakine)].
    Nederlands tijdschrift voor geneeskunde, 1980, Aug-23, Volume: 124, Issue:34

    Topics: Anticonvulsants; Chemical and Drug Induced Liver Injury; Child; Epilepsy; Female; Humans; Liver; Val

1980
Variable in vivo binding of valproic acid in epilepsy patients being medicated with other anticonvulsants.
    Clinical chemistry, 1980, Volume: 26, Issue:11

    Topics: Binding, Competitive; Epilepsy; Humans; Phenytoin; Serum Albumin; Valproic Acid

1980
Therapeutic alternatives in phenytoin-induced gingival hyperplasia. A case report and discussion.
    Journal of periodontology, 1980, Volume: 51, Issue:9

    Topics: Adolescent; Epilepsy; Female; Gingival Hyperplasia; Humans; Phenytoin; Primidone; Valproic Acid

1980
Binding of drugs to human serum albumin. XIV. The theoretical basis for the interaction between phenytoin and valproate.
    Molecular pharmacology, 1980, Volume: 18, Issue:2

    Topics: Adolescent; Binding, Competitive; Blood Proteins; Child; Epilepsy; Humans; Phenytoin; Protein Bindin

1980
Simplified simultaneous determination of valproic acid and ethosuximide in serum by gas-liquid chromatography.
    Clinical chemistry, 1980, Volume: 26, Issue:12

    Topics: Chromatography, Gas; Epilepsy; Ethosuximide; Humans; Valproic Acid

1980
Interaction between phenytoin and valproate.
    The Medical journal of Australia, 1980, Aug-23, Volume: 2, Issue:4

    Topics: Blood Proteins; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Phenytoin; Protein B

1980
[Problems of therapeutic service in valproate therapy].
    Zeitschrift fur arztliche Fortbildung, 1980, Aug-01, Volume: 74, Issue:15

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsy; Humans

1980
Determination of valproic acid kinetics in patients during maintenance therapy using a tetradeuterated form of the drug.
    Biomedical mass spectrometry, 1980, Volume: 7, Issue:4

    Topics: Epilepsy; Gas Chromatography-Mass Spectrometry; Half-Life; Humans; Valproic Acid

1980
Pharmacokinetics of anticonvulsant drugs.
    Acta neurologica Scandinavica. Supplementum, 1980, Volume: 80

    Topics: Anticonvulsants; Binding, Competitive; Brain; Carbamazepine; Drug Interactions; Drug Tolerance; Epil

1980
Prophylaxis and febrile convulsions.
    Archives of disease in childhood, 1981, Volume: 56, Issue:2

    Topics: Child; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Phenobarbital; Recurrence; Seizures; Se

1981
Drug interactions in epilepsy.
    Arquivos de neuro-psiquiatria, 1980, Volume: 38, Issue:4

    Topics: Anticonvulsants; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Humans; Isoniazid; P

1980
Mechanism of valproate-phenobarbital interaction in epileptic patients.
    Clinical pharmacology and therapeutics, 1981, Volume: 29, Issue:4

    Topics: Adolescent; Adult; Child; Drug Interactions; Epilepsy; Female; Humans; Kinetics; Male; Phenobarbital

1981
Concentration of metabolites of valproic acid in plasma of epileptic patients.
    Epilepsia, 1981, Volume: 22, Issue:2

    Topics: Adolescent; Adult; Biotransformation; Chromatography, Gas; Epilepsy; Female; Humans; Male; Middle Ag

1981
Effects of sodium valproate administered acutely I.V. on human and experimental EEG epileptic foci.
    Il Farmaco; edizione pratica, 1980, Volume: 35, Issue:12

    Topics: Animals; Brain; Electroencephalography; Epilepsy; Humans; Rabbits; Seizures; Valproic Acid

1980
Valproic acid in childhood epilepsy: anticonvulsive efficacy in relation to its plasma levels.
    International journal of clinical pharmacology, therapy, and toxicology, 1980, Volume: 18, Issue:10

    Topics: Adolescent; Child; Drug Therapy, Combination; Epilepsy; Humans; Phenobarbital; Valproic Acid

1980
Valproate-induced stomatitis.
    Neurology, 1981, Volume: 31, Issue:3

    Topics: Adult; Epilepsy; Female; Humans; Nicotinic Acids; Stomatitis; Valproic Acid

1981
[Results of treatment of epilepsy with Convulex].
    Sbornik vedeckych praci Lekarske fakulty Karlovy univerzity v Hradci Kralove. Supplementum, 1980, Volume: 23, Issue:4

    Topics: Adolescent; Adult; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Middle Aged; Valproic Ac

1980
Drug treatment of epilepsy.
    Comprehensive therapy, 1981, Volume: 7, Issue:4

    Topics: Anticonvulsants; Carbamazepine; Clonazepam; Electroencephalography; Epilepsy; Ethosuximide; Female;

1981
Valproic acid disposition in epileptic patients during combined antiepileptic maintenance therapy.
    European journal of clinical pharmacology, 1981, Volume: 19, Issue:5

    Topics: Adolescent; Adult; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Metabolic Clearance Ra

1981
[Daily fluctuations of plasma diphenylhydantoin in patients treated with diphenylhydantoin and sodium valproate].
    Acta neurologica, 1981, Volume: 3, Issue:1

    Topics: Adult; Circadian Rhythm; Drug Therapy, Combination; Epilepsy; Humans; Phenytoin; Valproic Acid

1981
[A neuro-immunological hypothesis for some forms of epilepsy].
    Acta neurologica, 1981, Volume: 3, Issue:1

    Topics: Adolescent; Adult; Carbamazepine; Epilepsy; Humans; Hydantoins; Immunoglobulins; Immunologic Deficie

1981
[The use of dipropylacetamide in antiepileptic therapy. Pharmacological and clinical aspects].
    Acta neurologica, 1981, Volume: 3, Issue:1

    Topics: Epilepsy; Humans; Valproic Acid

1981
Valproic acid fails to displace phenobarbitone and carbamazepine from plasma protein binding sites in epileptic patients.
    British journal of clinical pharmacology, 1981, Volume: 12, Issue:1

    Topics: Adolescent; Adult; Binding, Competitive; Blood Proteins; Carbamazepine; Epilepsy; Female; Humans; Ma

1981
The effect of concurrent administration of valproate sodium on phenobarbital plasma concentration/dosage ratio in pediatric patients.
    The Journal of pediatrics, 1981, Volume: 99, Issue:2

    Topics: Adolescent; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Inf

1981
Plasma GABA levels in neurological patients under treatment with valproic acid.
    Life sciences, 1981, May-21, Volume: 28, Issue:21

    Topics: Adult; Aged; Epilepsy; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Time Factors; Valproic Ac

1981
Lack of effect of valproate on paracetamol (acetaminophen) disposition in epileptic patients.
    British journal of clinical pharmacology, 1981, Volume: 11, Issue:4

    Topics: Acetaminophen; Adult; Drug Interactions; Epilepsy; Humans; Kinetics; Male; Valproic Acid

1981
Effects of sodium valproate in 100 children with special reference to weight.
    British medical journal (Clinical research ed.), 1981, Aug-29, Volume: 283, Issue:6291

    Topics: Adolescent; Appetite; Body Weight; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male;

1981
Pharmacology of valproic acid in children with severe epilepsy: clearance and hepatotoxicity.
    Neurology, 1981, Volume: 31, Issue:8

    Topics: Adolescent; Adult; Aspartate Aminotransferases; Child; Child, Preschool; Epilepsy; Humans; Liver Fun

1981
[Mg valproate plasma levels in epileptic patients, measured by gas-liquid chromatography (author's transl)].
    Revista medica de Chile, 1981, Volume: 109, Issue:1

    Topics: Chromatography, Gas; Epilepsy; Humans; Valproic Acid

1981
[Daily plasma fluctuations of diphenylhydantoin in patients treated with diphenylhydantoin and sodium valproate].
    Acta neurologica. Quaderni, 1981, Volume: 42

    Topics: Adult; Epilepsy; Humans; Phenytoin; Time Factors; Valproic Acid

1981
[The use of dipropylacetamide in anti-epileptic therapy. Pharmacological and clinical aspects].
    Acta neurologica. Quaderni, 1981, Volume: 42

    Topics: Epilepsy; Humans; Valproic Acid

1981
Recent advances in the treatment of epilepsy.
    Acta neurologica Scandinavica. Supplementum, 1980, Volume: 78

    Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Huma

1980
Sodium valproate reassessed.
    Drug and therapeutics bulletin, 1981, Nov-20, Volume: 19, Issue:24

    Topics: Adult; Epilepsy; Humans; Liver; Valproic Acid

1981
Serum protein binding of diazepam and its displacement by valproic acid in vitro.
    British journal of clinical pharmacology, 1981, Volume: 12, Issue:4

    Topics: Binding, Competitive; Diazepam; Epilepsy; Humans; In Vitro Techniques; Serum Albumin; Valproic Acid

1981
Rapid gas chromatographic determination of valproic acid in serum.
    Journal of chromatography, 1981, Oct-09, Volume: 225, Issue:2

    Topics: Chromatography, Gas; Epilepsy; Humans; Valproic Acid

1981
Valproic acid and its metabolites: placental transfer, neonatal pharmacokinetics, transfer via mother's milk and clinical status in neonates of epileptic mothers.
    The Journal of pharmacology and experimental therapeutics, 1981, Volume: 219, Issue:3

    Topics: Abnormalities, Drug-Induced; Aminopyrine; Breath Tests; Epilepsy; Female; Fetal Blood; Half-Life; Hu

1981
[Complications of valproic acid therapy: an overview (author's transl)].
    Der Nervenarzt, 1981, Volume: 52, Issue:10

    Topics: Adult; Alcohol Withdrawal Delirium; Chemical and Drug Induced Liver Injury; Child; Coma; Electroence

1981
Sodium valproate in pregnancy.
    The New Zealand medical journal, 1981, Sep-23, Volume: 94, Issue:692

    Topics: Adult; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complications; Valproic Acid

1981
[Tremor in the course of sodium valproate treatment].
    La Nouvelle presse medicale, 1981, Sep-26, Volume: 10, Issue:34

    Topics: Age Factors; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Tremor; Valproic Acid

1981
Phenytoin-valproate interaction: importance of saliva monitoring in epilepsy.
    British medical journal (Clinical research ed.), 1982, Jan-02, Volume: 284, Issue:6308

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Drug Interactions; Drug Therapy, Combination; Epil

1982
Valproic acid and several metabolites: quantitative determination in serum, urine, breast milk and tissues by gas chromatography-mass spectrometry using selected ion monitoring.
    Journal of chromatography, 1981, Nov-13, Volume: 226, Issue:1

    Topics: Adult; Animals; Epilepsy; Female; Gas Chromatography-Mass Spectrometry; Humans; Infant, Newborn; Mic

1981
Depamide: a preliminary report on its therapeutic efficacy in epilepsy.
    Monographs in neural sciences, 1980, Volume: 5

    Topics: Adolescent; Adult; Anticonvulsants; Behavior; Child; Drug Evaluation; Drug Interactions; Electroence

1980
Sodium dipropylacetate (Vupral Polfa) in therapy of resistant epilepsy.
    Monographs in neural sciences, 1980, Volume: 5

    Topics: Adolescent; Adult; Drug Resistance; Electroencephalography; Epilepsy; Female; Humans; Male; Middle A

1980
Daily fluctuations of dipropylacetate (DPA) serum level in epileptic patients.
    Monographs in neural sciences, 1980, Volume: 5

    Topics: Adolescent; Adult; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Middle

1980
A computer analysis of specific and aspecific interictal epileptic activity in man.
    Monographs in neural sciences, 1980, Volume: 5

    Topics: Computers; Electroencephalography; Epilepsy; Humans; Phenobarbital; Valproic Acid

1980
[Sodium valproate, platelet dysfunction and bleeding (author's transl)].
    La Nouvelle presse medicale, 1981, Dec-19, Volume: 10, Issue:46

    Topics: Blood Platelet Disorders; Epilepsy; Humans; Thrombocytopenia; Valproic Acid

1981
Serial free and plasma valproic acid and phenytoin monitoring and drug interactions.
    Therapeutic drug monitoring, 1981, Volume: 3, Issue:3

    Topics: Adolescent; Adult; Circadian Rhythm; Drug Interactions; Epilepsy; Female; Humans; Male; Phenytoin; V

1981
Dipropylacetic acid plasma levels; diurnal fluctuations during chronic treatment with dipropylacetamide.
    Therapeutic drug monitoring, 1981, Volume: 3, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Child; Circadian Rhythm; Epilepsy; Humans; Valproic Acid

1981
[Relation between plasma levels of valproic acid alone and its efficacy and toxicity in pediatric patients under chronic treatment].
    Archivos de farmacologia y toxicologia, 1981, Volume: 7, Issue:1

    Topics: Child; Child, Preschool; Drug Evaluation; Epilepsy; Humans; Infant; Seizures; Seizures, Febrile; Val

1981
The free fraction of valproic acid in tears, saliva, and cerebrospinal fluid.
    Epilepsia, 1982, Volume: 23, Issue:1

    Topics: Adult; Child; Epilepsy; Humans; Immunoenzyme Techniques; Protein Binding; Saliva; Tears; Valproic Ac

1982
Plasma levels and pharmacokinetics of antipileptic drugs in children.
    Folia psychiatrica et neurologica japonica, 1981, Volume: 35, Issue:3

    Topics: Adolescent; Age Factors; Anticonvulsants; Biological Availability; Biotransformation; Carbamazepine;

1981
Rapid and simple GLC determination of valproic acid and ethosuximide in plasma of epileptic patients.
    Journal of pharmaceutical sciences, 1982, Volume: 71, Issue:1

    Topics: Chromatography, Gas; Epilepsy; Ethosuximide; Humans; Valproic Acid

1982
Free sodium valproate monitoring.
    British journal of clinical pharmacology, 1982, Volume: 13, Issue:3

    Topics: Adolescent; Adult; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Middle Aged; Time Factor

1982
Increased serum phospholipids in epileptic children treated with phenobarbitone.
    Journal of neurology, neurosurgery, and psychiatry, 1982, Volume: 45, Issue:1

    Topics: Child; Child, Preschool; Epilepsy; Female; Humans; Male; Phenobarbital; Phospholipids; Valproic Acid

1982
Saliva and serum valproic acid levels in epileptic children.
    The Journal of pediatrics, 1982, Volume: 100, Issue:3

    Topics: Child; Epilepsy; Female; Humans; Male; Saliva; Valproic Acid

1982
Differentiating between organic and functional seizures: a common diagnostic problem.
    Australian family physician, 1981, Volume: 10, Issue:12

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Diagnosis, Differential; Dose-Response Relationsh

1981
[Clinical irrelevance of the hematologic side effects of sodium valproate (Depakine)].
    Revista de medicina de la Universidad de Navarra, 1981, Volume: 25, Issue:3

    Topics: Adult; Age Factors; Anticonvulsants; Autoantibodies; Blood Coagulation Disorders; Blood Platelets; C

1981
Interaction between valproic acid and aspirin in epileptic children: serum protein binding and metabolic effects.
    Clinical pharmacology and therapeutics, 1982, Volume: 31, Issue:5

    Topics: Aspirin; Blood Proteins; Child; Child, Preschool; Drug Interactions; Epilepsy; Female; Humans; Kinet

1982
Side effects of sodium valproate in monotherapy controlled by plasma levels: a study in 88 pediatric patients.
    Epilepsia, 1982, Volume: 23, Issue:2

    Topics: Child; Child Behavior Disorders; Child, Preschool; Digestive System Diseases; Epilepsy; Female; Hair

1982
Diurnal oscillations in plasma protein binding of valproic acid.
    Epilepsia, 1982, Volume: 23, Issue:3

    Topics: Adolescent; Adult; Blood Proteins; Circadian Rhythm; Epilepsy; Fatty Acids, Nonesterified; Female; H

1982
Stuporous episodes during treatment with sodium valproate: report of seven cases.
    Epilepsia, 1982, Volume: 23, Issue:3

    Topics: Anticonvulsants; Cognition Disorders; Consciousness Disorders; Electroencephalography; Epilepsy; Fem

1982
Valproate-induced hyperammonemia.
    Annals of neurology, 1982, Volume: 11, Issue:3

    Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Ammonia; Anticonvulsants; Carbamoyl-Phosphate Synt

1982
American Academy of Pediatrics Committee on Drugs: Valproic acid: benefits and risks.
    Pediatrics, 1982, Volume: 70, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Drug Interactions; Epilepsy; Humans; Valproic Acid

1982
Monitoring free valproic acid in epilepsy patients medicated with coanticonvulsants.
    Therapeutic drug monitoring, 1982, Volume: 4, Issue:2

    Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Phenytoin; Valpro

1982
Treatment of primary reading epilepsy with valproic acid.
    Archives of neurology, 1982, Volume: 39, Issue:7

    Topics: Adult; Electroencephalography; Epilepsy; Female; Humans; Reading; Valproic Acid

1982
The effects of anticonvulsants on memory function in epileptic patients: preliminary findings.
    Clinical and experimental neurology, 1981, Volume: 17

    Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Memory; Memory, Short-Term; Mental Recall; Phenyto

1981
["Fever convulsions" in children. Current viewpoints on diagnosis, therapy and prognosis].
    Fortschritte der Medizin, 1982, Jun-24, Volume: 100, Issue:24

    Topics: Child, Preschool; Diagnosis, Differential; Diazepam; Epilepsy; Humans; Infant; Parents; Phenobarbita

1982
[Clinical evaluation of certain modern antiepileptic preparations].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1982, Volume: 82, Issue:6

    Topics: Anticonvulsants; Automatism; Carbamazepine; Child; Clonazepam; Diencephalon; Epilepsy; Epilepsy, Abs

1982
Clinical and pharmacokinetic observations on sodium valproate - a 5-year follow-up study in 100 children with epilepsy.
    Acta neurologica Scandinavica, 1982, Volume: 65, Issue:5

    Topics: Adolescent; Child; Child, Preschool; Dose-Response Relationship, Drug; Electroencephalography; Epile

1982
Sodium valproate in the treatment of the intractable childhood epileptic.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1982, Volume: 9, Issue:3

    Topics: Adolescent; Adult; Child; Child, Preschool; Chronic Disease; Drug Therapy, Combination; Education of

1982
Valproic acid and immune thrombocytopenia.
    Archives of disease in childhood, 1982, Volume: 57, Issue:9

    Topics: Adolescent; Adult; Anticonvulsants; Blood Platelets; Child; Child, Preschool; Drug Therapy, Combinat

1982
Intra-dose variation in plasma protein binding of sodium valproate in epileptic patients.
    British journal of clinical pharmacology, 1982, Volume: 14, Issue:3

    Topics: Adolescent; Adult; Blood Proteins; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Male;

1982
[Dipropyl-N-acetate (Convulex) in the treatment of epileptic seizures in childhood (5-year clinical experience)].
    Ceskoslovenska neurologie a neurochirurgie, 1982, Volume: 45, Issue:4

    Topics: Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Valproic Acid

1982
Valproic acid and spina bifida: a preliminary report--France.
    MMWR. Morbidity and mortality weekly report, 1982, Oct-29, Volume: 31, Issue:42

    Topics: Epilepsy; Female; France; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pregnancy; Spina Bifida

1982
Antipyrine disposition in relation to lowered anticonvulsant plasma level during pregnancy.
    Obstetrics and gynecology, 1982, Volume: 60, Issue:5

    Topics: Adult; Anticonvulsants; Antipyrine; Delivery, Obstetric; Dose-Response Relationship, Drug; Epilepsy;

1982
[Inhibition by dipropyl acetate and its structural analogs of the glycine synthase system in liver and brain mitochondria].
    Revista espanola de fisiologia, 1982, Volume: 38 Suppl

    Topics: Amino Acid Oxidoreductases; Animals; Anticonvulsants; Brain; Carrier Proteins; Epilepsy; Glycine; Ma

1982
Plasma levels of sodium valproate in childhood epilepsy.
    Scottish medical journal, 1982, Volume: 27, Issue:4

    Topics: Adolescent; Age Factors; Body Weight; Child; Child, Preschool; Dose-Response Relationship, Drug; Dru

1982
Sodium valproate: monotherapy and polytherapy.
    Epilepsia, 1982, Volume: 23, Issue:6

    Topics: Adolescent; Adult; Carbamazepine; Drug Therapy, Combination; Epilepsies, Myoclonic; Epilepsies, Part

1982
[Laboratory parameters in valproate therapy].
    Der Nervenarzt, 1982, Volume: 53, Issue:12

    Topics: Adolescent; Adult; Blood Coagulation Tests; Child; Child, Preschool; Drug Therapy, Combination; Enzy

1982
Determination of unbound valproic acid concentration in plasma by equilibrium dialysis and gas--liquid chromatography: methodological aspects and observations in epileptic patients.
    Therapeutic drug monitoring, 1982, Volume: 4, Issue:4

    Topics: Blood Preservation; Blood Proteins; Chromatography, Gas; Dialysis; Epilepsy; Fatty Acids, Nonesterif

1982
Therapeutic concentration of antiepileptic drugs and the severity of epileptogenesis.
    Electroencephalography and clinical neurophysiology. Supplement, 1982, Volume: 36

    Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Isoxazoles; Phenytoin; Valproic Acid; Zonisamide

1982
The use of the inter-ictal EEG in the study of antiepileptic drugs.
    Electroencephalography and clinical neurophysiology. Supplement, 1982, Volume: 36

    Topics: Adolescent; Adult; Anticonvulsants; Brain; Electroencephalography; Epilepsy; Female; Humans; Light;

1982
Stuporous states or coma induced by the rapid administration of high doses of sodium valproate.
    Italian journal of neurological sciences, 1982, Volume: 3, Issue:3

    Topics: Adult; Anticonvulsants; Barbiturates; Coma; Drug Therapy, Combination; Electroencephalography; Epile

1982
Comparison of the effectiveness of several formulations of sodium valproate: tablets, enteric-coated capsules, solutions and rectal capsules.
    Italian journal of neurological sciences, 1982, Volume: 3, Issue:3

    Topics: Adolescent; Adult; Capsules; Child; Child, Preschool; Drug Evaluation; Epilepsy; Humans; Infant; Rec

1982
Quantitative determination of n-dipropylacetamide in the plasma of epileptic patients by gas--liquid chromatography with nitrogen-selective detection.
    Journal of chromatography, 1982, Dec-10, Volume: 233

    Topics: Anticonvulsants; Chromatography, Gas; Epilepsy; Humans; Nitrogen; Valproic Acid

1982
[Human teratogenicity of valproic acid containing antiepileptic drugs].
    Orvosi hetilap, 1982, Dec-19, Volume: 123, Issue:51

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complic

1982
[The effect of anticonvulsive therapy on the psychological achievements in epileptic children].
    Arztliche Jugendkunde, 1982, Volume: 73, Issue:5

    Topics: Achievement; Adolescent; Carbamazepine; Child; Epilepsy; Female; Humans; Male; Valproic Acid

1982
Effect of valproic acid on hepatic functions.
    The Journal of the Association of Physicians of India, 1982, Volume: 30, Issue:8

    Topics: Adolescent; Adult; Child; Epilepsy; Female; Follow-Up Studies; Humans; Liver; Liver Function Tests;

1982
A multivariable evoked potential measure applied to human epilepsy.
    Neuroscience letters, 1980, Volume: 18, Issue:3

    Topics: Adult; Brain; Epilepsy; Evoked Potentials; Humans; Male; Models, Neurological; Photic Stimulation; V

1980
[A study on cerebrospinal fluid and saliva to serum concentration ratios of anticonvulsants--Phenytoin, Phenobarbital, Valproic Acid and Primidone in epileptic patients].
    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 1982, Volume: 84, Issue:9

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsy; Humans; Middle Aged; Phenobar

1982
[Indication of tele-electroencephalography coupled to videoscopy in the study of higher functions in the epileptic child].
    Revue d'electroencephalographie et de neurophysiologie clinique, 1982, Volume: 12, Issue:4

    Topics: Adolescent; Child; Child, Preschool; Double-Blind Method; Electroencephalography; Epilepsy; Evoked P

1982
[Readjustment of anticonvulsive therapy in children. Monitoring of the effects of sodium valproate after barbiturate withdrawal by electrophysiologic sleep studies].
    L'Encephale, 1982, Volume: 8, Issue:5

    Topics: Adolescent; Adult; Barbiturates; Child; Electroencephalography; Electromyography; Electrooculography

1982
Sodium valproate: pharmacokinetics and effectivensss in treating intractable seizures.
    Neurology, 1980, Volume: 30, Issue:1

    Topics: Adolescent; Adult; Child; Child, Preschool; Drug Interactions; Epilepsy; Female; Half-Life; Humans;

1980
Valproic acid and plasma levels of phenobarbital.
    Neurology, 1980, Volume: 30, Issue:1

    Topics: Adult; Animals; Cats; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Male; Phenobar

1980
Effect of single doses of sodium valproate on serum phenytoin levels and protein binding in epileptic patients.
    Clinical pharmacology and therapeutics, 1980, Volume: 27, Issue:1

    Topics: Adult; Blood Proteins; Epilepsy; Humans; Kinetics; Male; Phenytoin; Protein Binding; Valproic Acid

1980
Valproic acid in epilepsy.
    JAMA, 1980, Feb-01, Volume: 243, Issue:5

    Topics: Adolescent; Adult; Child; Child, Preschool; Drug Tolerance; Epilepsy; Humans; Middle Aged; Valproic

1980
Practical considerations in anticonvulsant therapy--Part 2.
    American pharmacy, 1995, Volume: NS35, Issue:9

    Topics: Anticonvulsants; Benzodiazepines; Cost Control; Epilepsy; Ethosuximide; Humans; Monitoring, Physiolo

1995
Erythrocyte antioxidant enzyme activities in children with myelomeningocele.
    Developmental medicine and child neurology, 1995, Volume: 37, Issue:10

    Topics: Adolescent; Adult; Child; Child, Preschool; Epilepsy; Erythrocytes; Female; Glutathione Peroxidase;

1995
Fetal valproate syndrome: clinical and neuro-developmental features in two sibling pairs.
    Developmental medicine and child neurology, 1994, Volume: 36, Issue:4

    Topics: Adult; Autistic Disorder; Child, Preschool; Clonazepam; Developmental Disabilities; Epilepsy; Family

1994
Increased fetal hemoglobin production in patients receiving valproic acid for epilepsy.
    Blood, 1994, Sep-01, Volume: 84, Issue:5

    Topics: Adult; Amides; Arginine; Butyrates; Epilepsy; Fetal Hemoglobin; Humans; Phenylacetates; Phenylbutyra

1994
Negative myoclonus during valproate-related stupor. Neurophysiological evidence of a cortical non-epileptic origin.
    Electroencephalography and clinical neurophysiology, 1995, Volume: 94, Issue:2

    Topics: Adult; Age of Onset; Cerebral Cortex; Electroencephalography; Epilepsies, Partial; Epilepsy; Female;

1995
Dose-dependent anticonvulsant and proconvulsant effects of nitric oxide synthase inhibitors on seizure threshold in a cortical stimulation model in rats.
    European journal of pharmacology, 1995, Feb-14, Volume: 274, Issue:1-3

    Topics: Amino Acid Oxidoreductases; Analysis of Variance; Animals; Arginine; Cerebral Cortex; Disease Models

1995
Plasma trace element, plasma glutathione peroxidase, and superoxide dismutase levels in epileptic children receiving antiepileptic drug therapy.
    Epilepsia, 1995, Volume: 36, Issue:6

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Erythrocytes; Female;

1995
Neurological deterioration in patients with urea cycle disorders under valproate therapy--a cause for concern.
    European journal of pediatrics, 1995, Volume: 154, Issue:7

    Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Ammonia; Arginine; Child; Epilepsy; Female; Humans

1995
Reversible dementia and apparent brain atrophy during valproate therapy.
    Annals of neurology, 1995, Volume: 38, Issue:4

    Topics: Atrophy; Brain Diseases; Child; Child, Preschool; Dementia; Epilepsy; Female; Humans; Magnetic Reson

1995
Stimulation of fetal hemoglobin production by short chain fatty acids.
    Blood, 1995, Oct-15, Volume: 86, Issue:8

    Topics: Adult; Anemia, Sickle Cell; Animals; Anticonvulsants; Butyrates; Butyric Acid; Cells, Cultured; Epil

1995
Bradycardia, an epileptic ictal manifestation.
    Seizure, 1995, Volume: 4, Issue:3

    Topics: Adult; Anticonvulsants; Bradycardia; Electrocardiography; Electroencephalography; Epilepsy; Epilepsy

1995
Effects of carbamazepine and valproate on brainstem auditory evoked potentials in epileptic children.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 1995, Volume: 11, Issue:8

    Topics: Anticonvulsants; Auditory Pathways; Brain Stem; Carbamazepine; Child; Child, Preschool; Epilepsies,

1995
Valproate-associated pancreatitis and cholecystitis in six mentally retarded adults.
    The Journal of clinical psychiatry, 1995, Volume: 56, Issue:11

    Topics: Adult; Anticonvulsants; Bipolar Disorder; Cholecystitis; Comorbidity; Epilepsy; Humans; Intellectual

1995
Psychotropic medications and their effects on sexual function.
    The Journal of clinical psychiatry, 1995, Volume: 56, Issue:11

    Topics: Bupropion; Epilepsy; Female; Humans; Male; Psychotropic Drugs; Selective Serotonin Reuptake Inhibito

1995
Cytokine production in blood mononuclear cells from epileptic patients.
    Epilepsia, 1995, Volume: 36, Issue:4

    Topics: Adolescent; Adult; Carbamazepine; Cytokines; Epilepsy; Female; Humans; Interleukin-1; Interleukin-2;

1995
Extracellular magnesium and anticonvulsant effects of valproate in young rat hippocampus.
    Epilepsia, 1995, Volume: 36, Issue:4

    Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Epilepsy; gamma-Aminobutyric Acid; Hippocampu

1995
Valproic acid-carbamazepine interaction: is valproic acid a selective inhibitor of epoxide hydrolase?
    Therapeutic drug monitoring, 1995, Volume: 17, Issue:3

    Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Drug Interactions; Epilepsy; Epoxide Hydr

1995
Eosinophilic pleural effusion associated with valproic acid administration.
    Southern medical journal, 1995, Volume: 88, Issue:8

    Topics: Adult; Epilepsy; Humans; Male; Pleural Effusion; Pulmonary Eosinophilia; Valproic Acid

1995
Distribution of unsaturated metabolites of valproate in human and rat brain--pharmacologic relevance?
    Epilepsia, 1995, Volume: 36, Issue:8

    Topics: Adolescent; Adult; Aged; Animals; Biological Transport; Blood-Brain Barrier; Brain; Brain Chemistry;

1995
Effect of carbamazepine and valproate on bone mineral density.
    The Journal of pediatrics, 1995, Volume: 127, Issue:2

    Topics: Absorptiometry, Photon; Adolescent; Bone Density; Calcium, Dietary; Carbamazepine; Case-Control Stud

1995
Anticonvulsant effect of intraventricular antiepileptic drugs. Experimental study.
    Neurological research, 1995, Volume: 17, Issue:3

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Epilepsy; Injections, Intraventricul

1995
Predicting unbound phenytoin concentrations in patients receiving valproic acid: a comparison of two prediction methods.
    The Annals of pharmacotherapy, 1995, Volume: 29, Issue:5

    Topics: Adult; Bias; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Pred

1995
Determination of urinary valproylcarnitine by gas chromatography-mass spectrometry with selected-ion monitoring.
    Journal of chromatography. B, Biomedical applications, 1995, Jan-06, Volume: 663, Issue:1

    Topics: Calibration; Carbon Tetrachloride; Carnitine; Dimethylformamide; Drug Stability; Epilepsy; Gas Chrom

1995
Drugs for epilepsy.
    The Medical letter on drugs and therapeutics, 1995, Apr-28, Volume: 37, Issue:947

    Topics: Adult; Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Epilepsy; Humans; Phenytoin

1995
Self-esteem and behavioural adjustment in children with epilepsy and children with diabetes.
    Journal of psychosomatic research, 1994, Volume: 38, Issue:8

    Topics: Adolescent; Carbamazepine; Child; Child Behavior Disorders; Cross-Sectional Studies; Diabetes Mellit

1994
Reduced carnitine and antiepileptic drugs: cause relationship or co-existence?
    Acta paediatrica (Oslo, Norway : 1992), 1995, Volume: 84, Issue:1

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Carnitine; Child; Child, Preschool; Epilepsy; Female; Hu

1995
A possible anti-emetic role for sodium valproate in cytotoxic chemotherapy.
    British journal of haematology, 1995, Volume: 89, Issue:4

    Topics: Antiemetics; Antineoplastic Agents; Drug Resistance; Epilepsy; Humans; Leukemia, Myeloid; Male; Midd

1995
[Sensitive physiologic perceptual tests for ocular side effects of drugs exemplified by various anticonvulsants].
    Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 1995, Volume: 92, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Color Perception; Contrast Sensitivity; Da

1995
Effects of antiepileptic drugs on EEG background activity in children with epilepsy: initial phase of therapy.
    Clinical EEG (electroencephalography), 1995, Volume: 26, Issue:2

    Topics: Alpha Rhythm; Anticonvulsants; Carbamazepine; Child; Delta Rhythm; Electroencephalography; Epilepsie

1995
[Changes in drug therapy and in seizure frequency in an institution for epilepsy patients between 1971 and 1986].
    Die Rehabilitation, 1994, Volume: 33, Issue:4

    Topics: Aged; Aged, 80 and over; Anticonvulsants; Barbiturates; Carbamazepine; Drug Therapy, Combination; Dr

1994
Neurologic factors predict a favorable valproate response in bipolar and schizoaffective disorders.
    Journal of clinical psychopharmacology, 1994, Volume: 14, Issue:5

    Topics: Bipolar Disorder; Brain Damage, Chronic; Cohort Studies; Double-Blind Method; Electroencephalography

1994
[Valproate related syndrome of inappropriate secretion of antidiuretic hormone (SIADH)--a case report].
    Rinsho shinkeigaku = Clinical neurology, 1994, Volume: 34, Issue:9

    Topics: Aged; Aged, 80 and over; Epilepsy; Humans; Inappropriate ADH Syndrome; Male; Valproic Acid

1994
Valproic acid-induced hyperammonemic encephalopathy: MR appearance.
    AJNR. American journal of neuroradiology, 1994, Volume: 15, Issue:9

    Topics: Adult; Ammonia; Atrophy; Brain Diseases, Metabolic; Cerebral Cortex; Diagnosis, Differential; Epilep

1994
Neonatal fibrinogen depletion caused by sodium valproate.
    The Annals of pharmacotherapy, 1994, Volume: 28, Issue:11

    Topics: Afibrinogenemia; Epilepsy; Female; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Pregnancy

1994
A comparative study of serum F protein and other liver function tests as an index of hepatocellular damage in epileptic patients.
    Acta neurologica Scandinavica, 1994, Volume: 89, Issue:4

    Topics: Adult; Alkaline Phosphatase; Anticonvulsants; Aspartate Aminotransferases; Carbamazepine; Chemical a

1994
Antiepileptics in the elderly. Pharmacoepidemiology and pharmacokinetics.
    Archives of family medicine, 1994, Volume: 3, Issue:7

    Topics: Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy; H

1994
[25 years of valproate in Switzerland].
    Praxis, 1994, Oct-04, Volume: 83, Issue:40

    Topics: Epilepsy; History, 20th Century; Humans; Switzerland; Valproic Acid

1994
[Sodium valproate and cognitive function].
    Praxis, 1994, Oct-04, Volume: 83, Issue:40

    Topics: Adolescent; Adult; Child; Epilepsy; Humans; Mental Processes; Neuropsychological Tests; Valproic Aci

1994
Bone marrow suppression induced by high dose valproic acid.
    Archives of disease in childhood, 1994, Volume: 71, Issue:2

    Topics: Anemia; Bone Marrow; Cells, Cultured; Colony-Forming Units Assay; Depression, Chemical; Epilepsy; Fe

1994
Aplasia cutis congenita of the scalp in an infant exposed to valproic acid in utero.
    Acta paediatrica (Oslo, Norway : 1992), 1994, Volume: 83, Issue:7

    Topics: Abnormalities, Drug-Induced; Adult; Causality; Epilepsy; Female; Humans; Infant, Newborn; Male; Preg

1994
Changes of thyroid hormone levels in epileptic patients.
    Journal of Tongji Medical University = Tong ji yi ke da xue xue bao, 1994, Volume: 14, Issue:2

    Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Male; Phenytoin; Thyrotropin; Thyro

1994
Epilepsy treatment in The Netherlands. Comparison of matched groups of two medical centres.
    Acta neurologica Scandinavica, 1994, Volume: 89, Issue:6

    Topics: Adolescent; Adult; Carbamazepine; Diazepam; Epilepsy; Ethosuximide; Female; gamma-Aminobutyric Acid;

1994
Impairment of consciousness induced by valproate treatment following neurosurgical operation.
    Acta neurochirurgica, 1993, Volume: 125, Issue:1-4

    Topics: Adolescent; Adult; Arousal; Brain Neoplasms; Cerebral Hemorrhage; Coma; Consciousness Disorders; Del

1993
The influence of polytherapy on the relationships between serum carbamazepine and its metabolites in epileptic children.
    Epilepsy research, 1994, Volume: 17, Issue:3

    Topics: Aging; Anticonvulsants; Body Weight; Carbamazepine; Child; Chromatography, High Pressure Liquid; Dru

1994
Choreiform movements associated with the use of valproate.
    Archives of neurology, 1994, Volume: 51, Issue:7

    Topics: Adolescent; Adult; Brain Injuries; Child; Chorea; Epilepsy; Female; Humans; Male; Valproic Acid

1994
Antiepileptic drug hypersensitivity syndrome: in vitro and clinical observations.
    Pediatric neurology, 1994, Volume: 10, Issue:2

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cross Reactions; Drug Hypersens

1994
A retrospective study of 113 epileptic patients treated with sustained-release valproate.
    Epilepsia, 1994, Volume: 35 Suppl 5

    Topics: Anticonvulsants; Carbamazepine; Delayed-Action Preparations; Drug Administration Schedule; Drug Ther

1994
[The efficacy of depakin in treatment-resistant epilepsy].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 1993, Volume: 93, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Chronic Disease; Drug Evaluation; Drug

1993
[Anticonvulsant activity of sodium valproate and various calcium antagonists during their combined use in mice].
    Biulleten' eksperimental'noi biologii i meditsiny, 1993, Volume: 115, Issue:3

    Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Drug Therapy, Combi

1993
Plasma amino acid alterations in idiopathic generalized epilepsy: an investigation in probands and their first-degree relatives.
    Italian journal of neurological sciences, 1994, Volume: 15, Issue:3

    Topics: Adult; Amino Acids; Aspartic Acid; Epilepsy; Family; Female; Glutamates; Glycine; Humans; Male; Taur

1994
Valproate-mediated disturbances of hemostasis: relationship to dose and plasma concentration.
    Neurology, 1994, Volume: 44, Issue:8

    Topics: Adult; Bleeding Time; Epilepsy; Female; Hemostasis; Humans; In Vitro Techniques; Male; Platelet Aggr

1994
[Hepatotoxicity induced by valproic acid in adults. Report of 3 cases].
    Revista medica de Chile, 1993, Volume: 121, Issue:12

    Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Epilepsy; Female; Humans; Male; Valproic

1993
Autism: electroencephalogram abnormalities and clinical improvement with valproic acid.
    Archives of pediatrics & adolescent medicine, 1994, Volume: 148, Issue:2

    Topics: Autistic Disorder; Brain; Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Humans;

1994
Pharmacodynamic interactions between phenytoin and valproate: individual and combined antiepileptic and neurotoxic actions in mice.
    Clinical neuropharmacology, 1994, Volume: 17, Issue:1

    Topics: Animals; Brain; Brain Diseases; Drug Interactions; Drug Synergism; Electroshock; Epilepsy; Female; M

1994
Pregnancy, epilepsy, management and outcome: a 10-year perspective.
    Seizure, 1993, Volume: 2, Issue:4

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Birth Weight; Carbamazepine; Cohort Studies; Drug Ther

1993
[Valproic acid: a simple method for the estimation of free serum concentration].
    Annales de biologie clinique, 1993, Volume: 51, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Albumins; Epilepsy; Female; Humans; Male; Middle Aged; V

1993
Psoriasiform eruption induced by anticonvulsants.
    Israel journal of medical sciences, 1994, Volume: 30, Issue:4

    Topics: Adult; Carbamazepine; Drug Eruptions; Epilepsy; Female; Humans; Male; Middle Aged; Psoriasis; Valpro

1994
Analysis of the transport of valproic acid into saliva from serum.
    Biological & pharmaceutical bulletin, 1994, Volume: 17, Issue:2

    Topics: Adolescent; Adult; Aged; Child; Diffusion; Epilepsy; Female; Humans; Male; Mathematics; Microvilli;

1994
Malformations, withdrawal manifestations, and hypoglycaemia after exposure to valproate in utero.
    Archives of disease in childhood, 1993, Volume: 69, Issue:3 Spec No

    Topics: Drug Administration Schedule; Epilepsy; Female; Heart Defects, Congenital; Humans; Infant, Newborn;

1993
The use of antiepileptic drug levels in children: a survey of Canadian pediatric neurologists.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1993, Volume: 20, Issue:3

    Topics: Adolescent; Anticonvulsants; Attitude of Health Personnel; Carbamazepine; Child; Epilepsy; Ethosuxim

1993
The rapid change to monotherapy with valproic acid in children.
    Journal of child neurology, 1993, Volume: 8, Issue:4

    Topics: Adolescent; Anticonvulsants; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Epilep

1993
Ammonia-independent modifications of the background EEG signal and paradoxical enhancement of epileptic abnormalities in EEG after acute administration of valproate to epileptic patients.
    Neuropharmacology, 1993, Volume: 32, Issue:9

    Topics: Adolescent; Adult; Ammonia; Arousal; Blood Glucose; Blood Pressure; Electroencephalography; Epilepsy

1993
Impaired fatty acid oxidation in children on valproic acid and the effect of L-carnitine.
    Neurology, 1993, Volume: 43, Issue:11

    Topics: Adolescent; Adult; Breath Tests; Carnitine; Child; Child, Preschool; Chromatography, High Pressure L

1993
Valproate and palmitate binding to serum albumin in valproate-treated patients. Relation to obesity.
    Epilepsy research, 1993, Volume: 16, Issue:1

    Topics: Adult; Body Mass Index; Epilepsy; Fatty Acids, Nonesterified; Female; Humans; Male; Middle Aged; Mod

1993
Nutritional factors and anticonvulsant therapies: effect on growth in children with epilepsy.
    The American journal of clinical nutrition, 1993, Volume: 58, Issue:6

    Topics: Carbamazepine; Child; Child Nutritional Physiological Phenomena; Child, Preschool; Cross-Sectional S

1993
Relationship of carnitine and carnitine precursors lysine, epsilon-N-trimethyllysine, and gamma-butyrobetaine in drug-induced carnitine depletion.
    Pediatric research, 1993, Volume: 34, Issue:4

    Topics: Adolescent; Bacteriuria; Betaine; Carnitine; Child; Child, Preschool; Creatinine; Epilepsy; Female;

1993
Changes in red blood cells with valproate therapy.
    Acta neurologica Scandinavica, 1993, Volume: 88, Issue:3

    Topics: Anemia, Macrocytic; Blood Platelets; Epilepsy; Erythrocyte Indices; Erythrocyte Volume; Erythrocytes

1993
Valproate retard granule: efficacy and side effects.
    The Japanese journal of psychiatry and neurology, 1993, Volume: 47, Issue:2

    Topics: Adolescent; Child; Child, Preschool; Delayed-Action Preparations; Dose-Response Relationship, Drug;

1993
Teratogenicity of antiepileptic drugs and drug specific malformations.
    The Japanese journal of psychiatry and neurology, 1993, Volume: 47, Issue:2

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug

1993
[Three cases of hypofibrinogenemia induced by chemotherapy with a combination of synthetic ACTH and valproic acid].
    No to hattatsu = Brain and development, 1994, Volume: 26, Issue:1

    Topics: Adrenocorticotropic Hormone; Afibrinogenemia; Child, Preschool; Drug Therapy, Combination; Epilepsy;

1994
Vitamins to prevent neural-tube defects.
    The New England journal of medicine, 1993, Jun-03, Volume: 328, Issue:22

    Topics: Epilepsy; Female; Humans; Neural Tube Defects; Pantothenic Acid; Pregnancy; Pregnancy Complications;

1993
Magnetic stimulation of the brain in generalized epilepsy: reversal of cortical hyperexcitability by anticonvulsants.
    Annals of neurology, 1993, Volume: 34, Issue:3

    Topics: Adolescent; Adult; Analysis of Variance; Brain; Child; Epilepsy; Female; Humans; Magnetics; Male; Mi

1993
Treating epilepsy--when, with what and by whom?
    The Ceylon medical journal, 1993, Volume: 38, Issue:2

    Topics: Adult; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complications; Seizures; Valproic Acid

1993
[Acute reversible liver necrosis after valproate therapy (immunologic hypersensitivity)].
    Padiatrie und Padologie, 1993, Volume: 28, Issue:2

    Topics: Child; Drug Hypersensitivity; Epilepsy; Humans; Liver; Liver Cirrhosis; Male; Necrosis; Transaminase

1993
Five years of anticonvulsant monitoring on site at the epilepsy clinic.
    Therapeutic drug monitoring, 1993, Volume: 15, Issue:2

    Topics: Anticonvulsants; Carbamazepine; Drug Monitoring; Epilepsy; Humans; Outpatient Clinics, Hospital; Phe

1993
An audit of therapeutic drug monitoring of anticonvulsants.
    The Ulster medical journal, 1995, Volume: 64, Issue:2

    Topics: Adult; Anticonvulsants; Carbamazepine; Child; Drug Monitoring; Epilepsy; Humans; Medical Audit; Nort

1995
Fetal valproate syndrome.
    Journal of medical genetics, 1995, Volume: 32, Issue:9

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Epilepsy; Face; Female; Human

1995
A model for estimating individualized valproate clearance values in children.
    Journal of clinical pharmacology, 1995, Volume: 35, Issue:10

    Topics: Administration, Oral; Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Ther

1995
Pharmacology of cortical epileptic afterdischarges in rats.
    Epilepsia, 1996, Volume: 37, Issue:4

    Topics: Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Dimethyl Sulfoxide; Disease Models, Animal

1996
Valproic acid hepatic fatalities. III. U.S. experience since 1986.
    Neurology, 1996, Volume: 46, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Child; Child, Preschool;

1996
Obesity and endocrine disorders in women taking valproate for epilepsy.
    Annals of neurology, 1996, Volume: 39, Issue:5

    Topics: Adult; Body Weight; Carbamazepine; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Endocrine

1996
Effect of valproate on cerebral metabolism and blood flow: an 18F-2-deoxyglucose and 15O water positron emission tomography study.
    Epilepsia, 1996, Volume: 37, Issue:6

    Topics: Adult; Brain; Carbamazepine; Cerebrovascular Circulation; Deoxyglucose; Dose-Response Relationship,

1996
Valproate-induced systemic lupus erythematosus in a patient with partial trisomy of chromosome 9 and epilepsy.
    Epilepsia, 1996, Volume: 37, Issue:6

    Topics: Adult; Chromosomes, Human, Pair 9; Comorbidity; Epilepsy; Female; HLA-DR4 Antigen; Humans; Intellect

1996
Weight loss in patients taking felbamate.
    Clinical neuropharmacology, 1995, Volume: 18, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Body Weight; Child; Epilepsy; Felbamate; Humans; Middle Aged; Ph

1995
[Study of the influence of anticonvulsant treatment on thyroid function].
    Anales de medicina interna (Madrid, Spain : 1984), 1995, Volume: 12, Issue:12

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Enzyme-Linked Immunosorbent Assay; E

1995
Effect of L-carnitine supplementation on acute valproate intoxication.
    Epilepsia, 1996, Volume: 37, Issue:7

    Topics: Ammonia; Carnitine; Coma; Drug Overdose; Epilepsy; Humans; Infant; Male; Oxidation-Reduction; Valpro

1996
Catamenial epilepsy: gynecological and hormonal implications. Five case reports.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 1996, Volume: 10, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Estradiol; Female; Humans; Premenstrual

1996
Valproate induced encephalopathy treated with carnitine in an adult.
    Journal of neurology, neurosurgery, and psychiatry, 1996, Volume: 61, Issue:2

    Topics: Adult; Anticonvulsants; Carnitine; Epilepsy; Female; Hepatic Encephalopathy; Humans; Liver; Valproic

1996
[Subependymal nodular heterotopia and epilepsy].
    Neurologia (Barcelona, Spain), 1996, Volume: 11, Issue:1

    Topics: Age of Onset; Anticonvulsants; Brain; Choristoma; Epilepsy; Female; Humans; Middle Aged; Pedigree; P

1996
Pharmacokinetics of slow-release preparations of sodium valproate.
    Psychiatry and clinical neurosciences, 1995, Volume: 49, Issue:5-6

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Delayed-Action Preparations; Dose-Respo

1995
Comparing antiepileptic drugs.
    Current opinion in neurology, 1996, Volume: 9, Issue:2

    Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Phenobarbital; Valproic Acid

1996
Clearance of phenytoin and valproic acid is affected by a small body weight reduction in an epileptic obese patient: a case study.
    Journal of clinical pharmacy and therapeutics, 1996, Volume: 21, Issue:2

    Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Half-Life; Humans; Metabolic Clearance Rate

1996
[The effects of phenobarbital, valproic acid and carbamazepine on the serum lipids and lipoproteins in a pediatric population].
    Anales espanoles de pediatria, 1996, Volume: 44, Issue:2

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Infan

1996
Fluctuations of 10-hydroxy-carbazepine during the day in epileptic patients.
    Acta neurologica Scandinavica, 1996, Volume: 93, Issue:6

    Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Huma

1996
The effects of antiepileptic drugs on serum zinc and copper levels in children.
    Journal of basic and clinical physiology and pharmacology, 1995, Volume: 6, Issue:3-4

    Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Copper; Drug Therapy, Combination; Epilepsy

1995
Radiological case of the month. In utero ultrasonographic demonstration of a lymphangioma.
    Archives of pediatrics & adolescent medicine, 1996, Volume: 150, Issue:10

    Topics: Adult; Epilepsy; Female; Fetal Diseases; Humans; Infant, Newborn; Liver Neoplasms; Lymphangioma, Cys

1996
The necessity of adjusting the dosage of zonisamide when coadministered with other anti-epileptic drugs.
    Biological & pharmaceutical bulletin, 1996, Volume: 19, Issue:8

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combinatio

1996
Detection of carbamazepine drug interaction by multiple peak approach screening using routine clinical pharmacokinetic data.
    Journal of clinical pharmacology, 1996, Volume: 36, Issue:8

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Interactions;

1996
Volvular epilepsy associated with line-of-migration abnormality: a case report.
    Journal of child neurology, 1996, Volume: 11, Issue:2

    Topics: Anticonvulsants; Cell Movement; Child; Electroencephalography; Epilepsy; Female; Frontal Lobe; Human

1996
Metabolite profiles in patients on high-dose valproate monotherapy.
    Epilepsy research, 1996, Volume: 25, Issue:2

    Topics: Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Liver; Male; Valproic Acid

1996
Salivary protein composition in epileptic patients on different medications.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 1996, Volume: 25, Issue:7

    Topics: Adult; Aged; Albumins; Amylases; Anticonvulsants; Carbamazepine; Cystatin C; Cystatins; Cysteine Pro

1996
Plasma tryptophan levels in children with epilepsy before and after antiepileptic treatment.
    Advances in experimental medicine and biology, 1996, Volume: 398

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Humans; Male; Tryptophan; Valpr

1996
The platelet aggregation in children with epilepsy receiving valproic acid.
    Thrombosis research, 1996, Feb-15, Volume: 81, Issue:4

    Topics: Adolescent; Anticonvulsants; Blood Coagulation Tests; Child; Child, Preschool; Epilepsy; Female; Hum

1996
New antiepileptic drugs: from discovery to practical use. Clinical directions for the future. Proceedings of the 3rd International Merritt-Putnam Symposium. Sydney, Australia, September 6, 1995.
    Epilepsia, 1996, Volume: 37 Suppl 6

    Topics: Anticonvulsants; Epilepsy; Humans; Valproic Acid

1996
[Embryofetopathy due to valproate: a pathology only little known. Apropos of 4 cases].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 1996, Volume: 3, Issue:9

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child, Preschool; Cleft Lip; Epilepsy; Face; Female; F

1996
Comparison of two binding equations for prediction of the concentration of unbound valproic acid in the serum of adult epileptic polytherapy patients.
    The Journal of pharmacy and pharmacology, 1996, Volume: 48, Issue:10

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Blood Proteins; Epilepsy; Female; Humans; Male; Middle Age

1996
Valproate metabolites in high-dose valproate plus phenytoin therapy.
    Epilepsia, 1996, Volume: 37, Issue:12

    Topics: Adolescent; Alanine Transaminase; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injur

1996
Suppression of cortical epileptic afterdischarges in developing rats by anticonvulsants increasing GABAergic inhibition.
    Epilepsy research, 1996, Volume: 25, Issue:3

    Topics: Animals; Anticonvulsants; Cerebral Cortex; Depression, Chemical; Drug Evaluation, Preclinical; Elect

1996
Effects of various valproic acid derivatives on low-calcium spontaneous epileptiform activity in hippocampal slices.
    Epilepsy research, 1995, Volume: 22, Issue:3

    Topics: Animals; Anticonvulsants; Calcium; Carbohydrates; Electroshock; Epilepsy; Hippocampus; In Vitro Tech

1995
Reduction in blood free carnitine levels in association with changes in sodium valproate (VPA) disposition in epileptic patients treated with VPA and other anti-epileptic drugs.
    Biological & pharmaceutical bulletin, 1997, Volume: 20, Issue:1

    Topics: Adult; Aged; Anticonvulsants; Carnitine; Epilepsy; Female; Humans; Male; Middle Aged; Valproic Acid

1997
Effect of topiramate on the pharmacokinetics of an oral contraceptive containing norethindrone and ethinyl estradiol in patients with epilepsy.
    Epilepsia, 1997, Volume: 38, Issue:3

    Topics: Adult; Anticonvulsants; Contraception; Contraceptives, Oral, Combined; Contraceptives, Oral, Synthet

1997
Mechanism for reduction of serum folate by antiepileptic drugs during prolonged therapy.
    Journal of the neurological sciences, 1997, Volume: 145, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Demography; Epilepsy; Fe

1997
Clinical pharmacokinetics of carbamazepine and valproate in children and adolescents with epilepsy.
    Neurologia i neurochirurgia polska, 1996, Volume: 30 Suppl 2

    Topics: Adolescent; Antidepressive Agents; Brain; Carbamazepine; Child; Child, Preschool; Epilepsy; Female;

1996
Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice.
    European journal of pharmacology, 1997, Mar-26, Volume: 323, Issue:1

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e

1997
Fetal valproate embryopathy in twins: genetic modification of the response to a teratogen.
    Birth defects original article series, 1996, Volume: 30, Issue:1

    Topics: Abnormalities, Multiple; Adult; Anticonvulsants; Diseases in Twins; Epilepsy; Female; Humans; Infant

1996
Interactions of clobazam with conventional antiepileptics in children.
    Journal of child neurology, 1997, Volume: 12, Issue:3

    Topics: Adolescent; Age Factors; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; C

1997
Color vision tests for early detection of antiepileptic drug toxicity.
    Neurology, 1997, Volume: 48, Issue:5

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Color Perception; Epilepsy; Humans; Osmolar Conce

1997
[Sturge-Weber syndrome: experience with 14 cases].
    Anales espanoles de pediatria, 1997, Volume: 46, Issue:2

    Topics: Anticonvulsants; Brain; Carbamazepine; Epilepsy; Female; Humans; Infant; Magnetic Resonance Imaging;

1997
Topiramate for epilepsy.
    The Medical letter on drugs and therapeutics, 1997, May-23, Volume: 39, Issue:1001

    Topics: Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Int

1997
Differential effect of carbamazepine and valproate monotherapy on plasma levels of oestrone sulphate and dehydroepiandrosterone sulphate in male epileptic patients.
    The Journal of endocrinology, 1997, Volume: 153, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Dehydroepiandrosterone; Dehydroepiandrosterone Su

1997
Effects of valproate, phenytoin, and MK-801 in a novel model of epileptogenesis.
    Epilepsia, 1997, Volume: 38, Issue:6

    Topics: Animals; Anticonvulsants; Behavior, Animal; Brain Stem; Disease Models, Animal; Dizocilpine Maleate;

1997
Persistence of photosensitivity.
    Epilepsia, 1997, Volume: 38, Issue:6

    Topics: Adolescent; Adult; Age Factors; Age of Onset; Anticonvulsants; Electroencephalography; Epilepsy; Fam

1997
[Acute hepatic failure associated with valproic acid in children. Report of 3 cases].
    Arquivos de neuro-psiquiatria, 1996, Volume: 54, Issue:4

    Topics: Anticonvulsants; Child, Preschool; Epilepsy; Female; Humans; Liver Failure, Acute; Male; Risk Factor

1996
Thrombocytopenic purpura and anemia in a breast-fed infant whose mother was treated with valproic acid.
    The Journal of pediatrics, 1997, Volume: 130, Issue:6

    Topics: Anemia; Anticonvulsants; Breast Feeding; Epilepsy; Female; Humans; Infant; Infant, Newborn; Maternal

1997
[Current knowledge on epilepsy, schizophrenia and spastic conditions. Neuro-Forum, Dresden, 5 April 1997].
    Fortschritte der Neurologie-Psychiatrie, 1997, Volume: 65, Issue:5 Suppl Fo

    Topics: Anticonvulsants; Carbamazepine; Chronic Disease; Epilepsies, Partial; Epilepsy; Humans; Remission In

1997
[Current knowledge on epilepsy, schizophrenia and spastic conditions. Neuro-Forum, Dresden, 5 April 1997].
    Psychiatrische Praxis, 1997, Volume: 24, Issue:3 Suppl

    Topics: Anticonvulsants; Carbamazepine; Chronic Disease; Epilepsies, Partial; Epilepsy; Humans; Remission In

1997
The effects of long-term anticonvulsive treatment on serum lipid profile.
    Acta paediatrica Japonica : Overseas edition, 1997, Volume: 39, Issue:3

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Fluorescence

1997
Serum lipids in epileptic children treated with carbamazepine and valproate.
    European journal of pediatrics, 1997, Volume: 156, Issue:7

    Topics: Adolescent; Analysis of Variance; Anticonvulsants; Apolipoproteins; Carbamazepine; Case-Control Stud

1997
Absence of bleeding complications in patients undergoing cortical surgery while receiving valproate treatment.
    Journal of neurosurgery, 1997, Volume: 87, Issue:2

    Topics: Adult; Cerebral Cortex; Epilepsy; Female; Hemorrhage; Humans; Male; Prognosis; Retrospective Studies

1997
AWD 140-190: a new anticonvulsant with a very good margin of safety.
    Epilepsy research, 1997, Volume: 28, Issue:1

    Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; E

1997
Diet- and valproate-induced transient hyperammonemia: effect of L-carnitine.
    Pediatric neurology, 1997, Volume: 16, Issue:4

    Topics: Administration, Oral; Adolescent; Ammonia; Anticonvulsants; Carnitine; Child; Diet; Epilepsy; Female

1997
Changes in serum lipids and lipoproteins in epileptic children treated with anticonvulsants.
    Journal of paediatrics and child health, 1997, Volume: 33, Issue:3

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Humans; Hyperlipidemias; Lipids

1997
Auditory event related potentials in patients with epilepsy on sodium valproate monotherapy.
    Acta neurologica Scandinavica, 1997, Volume: 96, Issue:1

    Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Evoked Potentials, Auditory; Female; Humans; Male;

1997
Clinical and economic impact of replacing divalproex sodium with valproic acid.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1997, Aug-01, Volume: 54, Issue:15

    Topics: Adult; Anticonvulsants; Costs and Cost Analysis; Epilepsy; Female; Hospitals, Psychiatric; Humans; I

1997
[Evaluation of the effect of long term valproic acid treatment on plasma levels of carnitine, ammonia and amino acids related to the urea cycle in pediatric epileptic patients].
    Revista de neurologia, 1997, Volume: 25, Issue:143

    Topics: Adolescent; Amino Acids; Ammonia; Anticonvulsants; Carnitine; Child; Child, Preschool; Epilepsy; Glu

1997
[The effect of enkorat on the course of epilepsy in children].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 1996, Volume: 96, Issue:4

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Evaluation; Epilepsy; Female; Humans; Mal

1996
Asymptomatic hyperammonemia in children treated with valproic acid.
    Journal of child neurology, 1997, Volume: 12, Issue:7

    Topics: Adolescent; Adult; Ammonia; Anticonvulsants; Carnitine; Child; Child, Preschool; Epilepsy; Female; H

1997
Detection of carbamazepine-induced changes in valproic acid relative clearance in man by simple pharmacokinetic screening.
    The Journal of pharmacy and pharmacology, 1997, Volume: 49, Issue:8

    Topics: Adolescent; Adult; Aging; Anticonvulsants; Body Weight; Carbamazepine; Child; Child, Preschool; Drug

1997
Menstrual cycle and ovary alterations in women with epilepsy on antiepileptic therapy.
    Journal of endocrinological investigation, 1997, Volume: 20, Issue:9

    Topics: Adolescent; Adult; Anovulation; Anticonvulsants; Corpus Luteum; Epilepsy; Female; Humans; Menstruati

1997
Polycystic ovary syndrome associated with treatment with the anticonvulsant sodium valproate.
    Current opinion in obstetrics & gynecology, 1997, Volume: 9, Issue:6

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Polycystic Ovary Syndrome; Pregnancy; Valproic Aci

1997
Oxcarbazepine in the treatment of early childhood epilepsy.
    Journal of child neurology, 1997, Volume: 12, Issue:8

    Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Resistance; Drug Therapy, Combination;

1997
[Lamotrigine (Lamictal)].
    Revue medicale de Liege, 1997, Volume: 52, Issue:11

    Topics: Anticonvulsants; Brain; Child; Child, Preschool; Drug Combinations; Drug Eruptions; Epilepsies, Part

1997
Hyponatremia due to sodium valproate.
    Annals of neurology, 1998, Volume: 43, Issue:2

    Topics: Anticonvulsants; Epilepsy; Humans; Hyponatremia; Male; Middle Aged; Valproic Acid

1998
Population-based investigation of valproic acid relative clearance using nonlinear mixed effects modeling: influence of drug-drug interaction and patient characteristics.
    Journal of clinical pharmacology, 1997, Volume: 37, Issue:12

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Interactions; Epile

1997
Studies of drugs in epilepsy cited by author are not evidence based.
    BMJ (Clinical research ed.), 1998, Feb-28, Volume: 316, Issue:7132

    Topics: Anticonvulsants; Carbamazepine; Drug Combinations; Epilepsy; Evidence-Based Medicine; GABA Agents; g

1998
[Experts take a position: Valproate--standard therapy in all forms of epilepsy].
    Der Nervenarzt, 1996, Volume: 67, Issue:6 Suppl Va

    Topics: Anticonvulsants; Epilepsy; Humans; Valproic Acid

1996
Treatment of the epileptic patient in the dental office.
    The New York state dental journal, 1998, Volume: 64, Issue:2

    Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Child; Dental Care for Chronically Ill; Emergencies; Ep

1998
To what extent do premenstrual and interictal dysphoric disorder overlap? Significance for therapy.
    Journal of affective disorders, 1998, Volume: 48, Issue:2-3

    Topics: Adult; Anticonvulsants; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepress

1998
Valproate, lamotrigine, and insulin-mediated risks in women with epilepsy.
    Annals of neurology, 1998, Volume: 43, Issue:4

    Topics: Analysis of Variance; Anticonvulsants; Cholesterol, HDL; Epilepsy; Female; Follow-Up Studies; Humans

1998
Side effect of ibuprofen and valproic acid.
    Orthopedics, 1998, Volume: 21, Issue:3

    Topics: Adolescent; Ankle Injuries; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Drug Interacti

1998
Urinary metabolites of valproic acid in epileptic patients.
    Biological & pharmaceutical bulletin, 1998, Volume: 21, Issue:3

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Epilepsy; Female; Gas Chromatography-Mass Spectrometry; Hu

1998
Valproate therapy does not deplete carnitine levels in otherwise healthy children.
    Pediatrics, 1998, Volume: 101, Issue:5

    Topics: Adolescent; Adult; Ammonia; Carnitine; Case-Control Studies; Child; Epilepsy; Female; Humans; Male;

1998
[Acquired aphasic epilepsy (Landau-Kleffner syndrome). Report of 10 cases].
    Anales espanoles de pediatria, 1997, Volume: 47, Issue:6

    Topics: Adrenocorticotropic Hormone; Anticonvulsants; Aphasia; Brain; Carbamazepine; Child; Child, Preschool

1997
Reversible pseudoatrophy of the brain and mental deterioration associated with valproate treatment.
    Epilepsia, 1998, Volume: 39, Issue:1

    Topics: Atrophy; Brain; Brain Diseases; Child; Cognition Disorders; Diagnosis, Differential; Electroencephal

1998
Interictal cardiovascular autonomic responses in patients with epilepsy.
    Epilepsia, 1998, Volume: 39, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Autonomic Nervous System; Blood Pressure; Epilepsy; Female; Hear

1998
Comparison of effects of valproate and trans-2-en-valproate on different forms of epileptiform activity in rat hippocampal and temporal cortex slices.
    Epilepsia, 1998, Volume: 39, Issue:3

    Topics: Action Potentials; Animals; Anticonvulsants; Electroencephalography; Entorhinal Cortex; Epilepsy; Ex

1998
Teratogenic effects of antiepileptic drugs: what do we advise patients?
    Epilepsia, 1997, Volume: 38, Issue:9

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Patient Advoc

1997
Migraine with visual aura and photosensitive epileptic seizures.
    Epilepsia, 1997, Volume: 38, Issue:9

    Topics: Adult; Comorbidity; Cortical Spreading Depression; Dopamine; Electroencephalography; Epilepsy; Human

1997
Detection of a drug-drug interaction on population-based phenobarbitone clearance using nonlinear mixed-effects modeling.
    European journal of clinical pharmacology, 1998, Volume: 54, Issue:1

    Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Body Weight; Carbamazepine; Child; Child, Preschool

1998
Veratridine-treated brain slices: a cellular model for epileptiform activity.
    Brain research, 1998, Apr-06, Volume: 789, Issue:1

    Topics: Action Potentials; Animals; Anticonvulsants; Brain; Electrophysiology; Epilepsy; In Vitro Techniques

1998
Does antiepileptic therapy affect immune response?
    Journal of chemotherapy (Florence, Italy), 1998, Volume: 10, Issue:2

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbama

1998
Replacement of divalproex sodium with valproic acid not clear-cut.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1998, May-15, Volume: 55, Issue:10

    Topics: Anticonvulsants; Epilepsy; Humans; Valproic Acid

1998
Complications of the ketogenic diet.
    Epilepsia, 1998, Volume: 39, Issue:7

    Topics: Adolescent; Carnitine; Child; Child, Preschool; Combined Modality Therapy; Epilepsy; Follow-Up Studi

1998
[Prenatal ultrasonographic diagnosis in the epileptic mother on valproic acid. Retrospective study of 161 cases in the central eastern France register of congenital malformations].
    Journal de gynecologie, obstetrique et biologie de la reproduction, 1998, Volume: 27, Issue:4

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; France; Humans; Population Surveilla

1998
Panipenem-betamipron and decreases in serum valproic acid concentration.
    Therapeutic drug monitoring, 1998, Volume: 20, Issue:4

    Topics: Adult; Anticonvulsants; beta-Alanine; Child, Preschool; Drug Interactions; Drug Therapy, Combination

1998
Peripheral benzodiazepine receptor expression on leukocytes and neutrophil function during anticonvulsant monotherapy.
    Pharmacology, 1998, Volume: 57, Issue:4

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Leukocytes; Lymph

1998
Reading epilepsy: report of five new cases and further considerations on the pathophysiology.
    Seizure, 1998, Volume: 7, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Electroencephalography; Epilepsy; Female; Humans; Kindling, Neur

1998
Antiepileptic drug treatment of West syndrome.
    Epilepsia, 1998, Volume: 39 Suppl 5

    Topics: Adrenocorticotropic Hormone; Anticonvulsants; Child; Drug Administration Schedule; Drug Therapy, Com

1998
Evaluation of bone mineral density in children receiving antiepileptic drugs.
    Pediatric neurology, 1998, Volume: 19, Issue:2

    Topics: Absorptiometry, Photon; Alkaline Phosphatase; Anticonvulsants; Bone Density; Calcium; Carbamazepine;

1998
Valproate therapy: predisposition to bone fracture?
    Pediatric neurology, 1998, Volume: 19, Issue:2

    Topics: Adolescent; Bone and Bones; Disease Susceptibility; Epilepsy; Female; Femoral Fractures; Foot; Fract

1998
Valproate selectively reduces the persistent fraction of Na+ current in neocortical neurons.
    Epilepsy research, 1998, Volume: 32, Issue:1-2

    Topics: Animals; Anticonvulsants; Cells, Cultured; Epilepsy; Humans; In Vitro Techniques; Membrane Potential

1998
Valproate and carbamazepine comedication changes hepatic enzyme activities in sera of epileptic children.
    Clinica chimica acta; international journal of clinical chemistry, 1998, Aug-28, Volume: 276, Issue:2

    Topics: Adolescent; Alanine Transaminase; Anticonvulsants; Aspartate Aminotransferases; Carbamazepine; Catal

1998
Changes of the EEG paroxysmal pattern during felbamate therapy in Lennox-Gastaut syndrome: a case report.
    The International journal of neuroscience, 1998, Volume: 95, Issue:3-4

    Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Clobazam; Drug Therapy,

1998
Valproate and polycystic ovaries.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1998, Volume: 37, Issue:10

    Topics: Adolescent; Adult; Anticonvulsants; Child; Epilepsy; Female; Humans; Hyperandrogenism; Polycystic Ov

1998
Quantifying the costs of serious adverse drug reactions to antiepileptic drugs.
    Epilepsia, 1998, Volume: 39 Suppl 7

    Topics: Adolescent; Adult; Anticonvulsants; Direct Service Costs; Drug Costs; Drug Hypersensitivity; Epileps

1998
L-carnitine supplementation in childhood epilepsy: current perspectives.
    Epilepsia, 1998, Volume: 39, Issue:11

    Topics: Age Factors; Ammonia; Anticonvulsants; Carnitine; Chemical and Drug Induced Liver Injury; Child; Chi

1998
Effects of new valproate derivatives on epileptiform discharges induced by pentylenetetrazole or low Mg2+ in rat entorhinal cortex-hippocampus slices.
    Epilepsy research, 1998, Volume: 32, Issue:3

    Topics: Animals; Anticonvulsants; Convulsants; Entorhinal Cortex; Epilepsy; Female; Glucose; Hippocampus; In

1998
[Serum lipids. lipoproteins, and apolipoproteins in adult epileptics treated with carbamazepine, valproic acid, or phenytoin].
    Revista de neurologia, 1998, Volume: 27, Issue:159

    Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Apolipoproteins; Carbamazepine; Cholesterol; Choles

1998
Lamotrigine and therapeutic drug monitoring: retrospective survey following the introduction of a routine service.
    British journal of clinical pharmacology, 1998, Volume: 46, Issue:6

    Topics: Anticonvulsants; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Epilepsy; Health Car

1998
Serum lipids and lipoproteins in patients treated with antiepileptic drugs.
    Pediatric neurology, 1998, Volume: 19, Issue:5

    Topics: Adolescent; Adult; Anticonvulsants; Apolipoprotein A-I; Apolipoproteins B; Carbamazepine; Cholestero

1998
Influence of valproate monotherapy on platelet activation and hematologic values.
    Epilepsia, 1999, Volume: 40, Issue:2

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Flow Cytometry; Fluorescent Antibody Technique; Hematologi

1999
N-acetyl-beta-glucosaminidase and beta-galactosidase activity in children receiving antiepileptic drugs.
    Pediatric neurology, 1999, Volume: 20, Issue:1

    Topics: Acetylglucosaminidase; Anticonvulsants; beta-Galactosidase; Biomarkers; Carbamazepine; Case-Control

1999
The effects of valproate, carbamazepine, and oxcarbazepine on growth and sexual maturation in girls with epilepsy.
    Pediatrics, 1999, Volume: 103, Issue:3

    Topics: Adolescent; Anthropometry; Anticonvulsants; Carbamazepine; Child; Cross-Sectional Studies; Epilepsy;

1999
[Encephalopathies caused by valproate].
    Fortschritte der Neurologie-Psychiatrie, 1999, Volume: 67, Issue:1

    Topics: Adult; Ammonia; Anticonvulsants; Brain Diseases; Drug Interactions; Epilepsy; Humans; Middle Aged; V

1999
Valproate treatment and platelet function: the role of arachidonate metabolites.
    Epilepsia, 1999, Volume: 40, Issue:3

    Topics: Adult; Arachidonic Acids; Blood Coagulation Tests; Blood Platelets; Epilepsy; Fasting; Hemorrhagic D

1999
Elevated plasma concentrations of homocysteine in antiepileptic drug treatment.
    Epilepsia, 1999, Volume: 40, Issue:3

    Topics: Age Factors; Ambulatory Care; Anticonvulsants; Carbamazepine; Convulsants; Depression, Chemical; Epi

1999
More on valproate and polycystic ovaries.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1999, Volume: 38, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Humans; Obesity; Polycystic Ovary Syndrome; Va

1999
Valproate-induced hyperandrogenism during pubertal maturation in girls with epilepsy.
    Annals of neurology, 1999, Volume: 45, Issue:4

    Topics: Adolescent; Child; Epilepsy; Female; Humans; Hyperandrogenism; Insulin; Insulin-Like Growth Factor B

1999
Intractable epilepsy.
    Lancet (London, England), 1999, Apr-10, Volume: 353, Issue:9160

    Topics: Abdominal Pain; Anticonvulsants; Carnitine; Child, Preschool; Epilepsy; Humans; Male; Valproic Acid

1999
Characterization of seizures in the flathead rat: a new genetic model of epilepsy in early postnatal development.
    Epilepsia, 1999, Volume: 40, Issue:4

    Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Cerebral Cortex; Disease Models, Animal; Electroe

1999
Valproate-induced biochemical abnormalities in pregnancy corrected by vitamins: a case report.
    Epilepsia, 1999, Volume: 40, Issue:4

    Topics: Adult; Anticonvulsants; Epilepsy; Ethosuximide; Female; Humans; Metabolic Diseases; Pantothenic Acid

1999
Male infertility: possible association with valproate exposure.
    Epilepsia, 1999, Volume: 40, Issue:4

    Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Felbamate; Female; Humans; Infertility,

1999
Valproate population pharmacokinetics in children.
    Journal of clinical pharmacy and therapeutics, 1999, Volume: 24, Issue:1

    Topics: Adolescent; Anticonvulsants; Biological Availability; Child; Child, Preschool; Drug Administration S

1999
Carnitine deficiency and hyperammonemia in children receiving valproic acid with and without other anticonvulsant drugs.
    International journal of clinical & laboratory research, 1999, Volume: 29, Issue:1

    Topics: Adolescent; Adult; Ammonia; Anticonvulsants; Carnitine; Child; Child, Preschool; Epilepsy; Female; H

1999
Safety of rapid intravenous infusion of valproate loading doses in epilepsy patients.
    Epilepsy research, 1999, Volume: 35, Issue:2

    Topics: Adolescent; Adult; Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Humans; Infusi

1999
Safe use of valproic acid during pregnancy.
    Canadian family physician Medecin de famille canadien, 1999, Volume: 45

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Neural Tube Defects; Pregnancy; Pregnancy Complica

1999
Fatal liver failure associated with valproate therapy in a patient with Friedreich's disease: review of valproate hepatotoxicity in adults.
    Epilepsia, 1999, Volume: 40, Issue:7

    Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Comorbidity; Epilepsy; Fatal Outcome; Fem

1999
Serum leptin changes in epileptic patients who gain weight after therapy with valproic acid.
    Neurology, 1999, Jul-13, Volume: 53, Issue:1

    Topics: Adolescent; Androgens; Anticonvulsants; Blood Glucose; Body Mass Index; Epilepsy; Female; Follicle S

1999
[Parenteral valproate optimizes emergency- and substitution therapy].
    Der Nervenarzt, 1999, Volume: 70, Issue:7 Suppl Pa

    Topics: Emergencies; Epilepsy; First Aid; Humans; Injections; Valproic Acid

1999
Valproic acid elimination rate and urinary excretion of its glucuronide conjugate in patients with epilepsy.
    Biological & pharmaceutical bulletin, 1999, Volume: 22, Issue:7

    Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Glucuronates; Humans; Kidney; Metabolic Clearance Rate

1999
Risk of excessive weight gain in epileptic children treated with valproate.
    Journal of child neurology, 1999, Volume: 14, Issue:8

    Topics: Adolescent; Adult; Anticonvulsants; Body Mass Index; Child; Child, Preschool; Dose-Response Relation

1999
Malformations in offspring of women with epilepsy: a prospective study.
    Epilepsia, 1999, Volume: 40, Issue:9

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Comorbidity; Congenital Abnormalities;

1999
Photo Quiz.
    Cutis, 1999, Volume: 64, Issue:3

    Topics: Aged; Anticonvulsants; Drug Interactions; Epilepsy; Female; Humans; Lamotrigine; Skin; Stevens-Johns

1999
Stevens-Johnson syndrome and antiepileptics.
    Lancet (London, England), 1999, Sep-18, Volume: 354, Issue:9183

    Topics: Adult; Anticonvulsants; Child; Drug Therapy, Combination; Epilepsy; Humans; Lamotrigine; Stevens-Joh

1999
Migraine polypharmacy and the tolerability of sumatriptan: a large-scale, prospective study.
    Cephalalgia : an international journal of headache, 1999, Volume: 19, Issue:7

    Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Anti-As

1999
Clinical experience with new antiepileptic drugs: antiepileptic drugs in Europe.
    Epilepsia, 1999, Volume: 40 Suppl 6

    Topics: Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Cross-Cultural Comparison; Drug Approval;

1999
Factors influencing the incidence of lamotrigine-related skin rash.
    The Annals of pharmacotherapy, 1999, Volume: 33, Issue:10

    Topics: Adolescent; Adult; Anticonvulsants; Child; Dose-Response Relationship, Drug; Drug Therapy, Combinati

1999
[Rett's syndrome: pathophysiology and anesthesiological implications].
    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 1999, Volume: 34, Issue:9

    Topics: Adult; Anesthesia; Anticonvulsants; Blood Coagulation Disorders; Epilepsy; Female; Humans; Kidney Ca

1999
[Recurrence of herpes simplex encephalitis].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 1999, Volume: 6, Issue:10

    Topics: Acyclovir; Anti-Anxiety Agents; Anti-Inflammatory Agents; Anticonvulsants; Antiviral Agents; Benzodi

1999
Modulation of sodium currents in rat CA1 neurons by carbamazepine and valproate after kindling epileptogenesis.
    Epilepsia, 1999, Volume: 40, Issue:11

    Topics: Animals; Anticonvulsants; Carbamazepine; Epilepsy; Hippocampus; Kindling, Neurologic; Male; Neurons;

1999
Valproate-induced hyperandrogenism during pubertal maturation in girls with epilepsy.
    Clinical pediatrics, 1999, Volume: 38, Issue:11

    Topics: Adolescent; Epilepsy; Female; Humans; Hyperandrogenism; Puberty; Sexual Maturation; Valproic Acid

1999
The effect of carbamazepine and sodium valproate on the blood and serum values of children from a third-world environment.
    Journal of child neurology, 1999, Volume: 14, Issue:11

    Topics: Adolescent; Anemia; Anticonvulsants; Black People; Carbamazepine; Child; Child, Preschool; Developin

1999
Long-term treatment of children with epilepsy with valproate or carbamazepine may cause subclinical hypothyroidism.
    Epilepsia, 1999, Volume: 40, Issue:12

    Topics: Adolescent; Age Factors; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Hypothyro

1999
Valproic acid intensifies epileptiform activity in the hippocampal pyramidal neurons.
    Neuroscience research, 1999, Dec-30, Volume: 35, Issue:4

    Topics: Action Potentials; Animals; Bicuculline; Disease Models, Animal; Epilepsy; GABA Antagonists; Hippoca

1999
Valproate-induced hyperammonemic encephalopathy in the presence of topiramate.
    Neurology, 2000, Jan-11, Volume: 54, Issue:1

    Topics: Adult; Ammonia; Anticonvulsants; Brain Diseases; Drug Therapy, Combination; Electroencephalography;

2000
Postoperative anticonvulsant prophylaxis for patients treated for cerebral aneurysms.
    Neurologia medico-chirurgica, 1999, Volume: 39, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Craniotomy; Drug Administration Schedule; Epilepsy;

1999
[A case report of valproate encephalopathy].
    Rinsho shinkeigaku = Clinical neurology, 1999, Volume: 39, Issue:10

    Topics: Adult; Ammonia; Anticonvulsants; Biomarkers; Brain; Brain Diseases; Carnitine; Epilepsy; Female; Hum

1999
Orthotopic liver transplantation with poor neurologic outcome in valproate-associated liver failure: a need for critical risk-benefit appraisal in the use of valproate.
    Transplantation proceedings, 2000, Volume: 32, Issue:1

    Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Fatal Outcome; Female; Humans; Infant; Liver Fai

2000
Valproic acid dosing recommendations questioned.
    Geriatrics, 2000, Volume: 55, Issue:2

    Topics: Adult; Age Factors; Anticonvulsants; Drug Combinations; Drug Interactions; Epilepsy; Half-Life; Huma

2000
Adverse response to methylphenidate in combination with valproic acid.
    Journal of child and adolescent psychopharmacology, 2000,Spring, Volume: 10, Issue:1

    Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Bruxism; Central Nervous System Stim

2000
Valproate for girls with epilepsy.
    Annals of neurology, 2000, Volume: 47, Issue:4

    Topics: Adolescent; Anticonvulsants; Child; Epilepsy; Female; Humans; Valproic Acid

2000
[Therapeutic antiepileptic drug monitoring: thirteen years of experience in the Laboratory of Clinical Neuropharmacology in the Chair and Department of Developmental neurology].
    Neurologia i neurochirurgia polska, 2000, Volume: 34 Suppl 1

    Topics: Academic Medical Centers; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy

2000
[Bimodal evoked potentials during long-term therapy with conventional or slow release preparations of carbamazepine and valproic acid in children and adolescents with epilepsy].
    Neurologia i neurochirurgia polska, 2000, Volume: 34 Suppl 1

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Evoked Potentials; Evoked Potentials, A

2000
[Effectiveness and tolerance of adjunctive treatment of lamotrigine and conversion to monotherapy in pediatric patients with epilepsy. Preliminary studies].
    Neurologia i neurochirurgia polska, 2000, Volume: 34 Suppl 1

    Topics: Adolescent; Adult; Anticonvulsants; Child; Drug Tolerance; Electroencephalography; Epilepsy; Female;

2000
Homocysteine concentrations and methionine loading in patients on antiepileptic drugs.
    Acta neurologica Scandinavica, 2000, Volume: 101, Issue:4

    Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Case-Control Studies; Cytochrome P-450 Enzyme System; E

2000
[Drug resistant epilepsy in Senegal: therapeutic, clinical and socioeconomic factors].
    Dakar medical, 1999, Volume: 44, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Resistance; Epilepsy; Female; Humans;

1999
Repeated acute testing of anticonvulsant drugs in amygdala kindled rats: increase in anticonvulsant but decrease in adverse effect potential.
    Epilepsia, 2000, Volume: 41, Issue:5

    Topics: Amygdala; Animals; Anticonvulsants; Ataxia; Behavior, Animal; Carbamazepine; Disease Models, Animal;

2000
Appropriate clinical management of women taking valproate.
    The Journal of clinical psychiatry, 2000, Volume: 61, Issue:3

    Topics: Adult; Age Factors; Anticonvulsants; Body Weight; Epilepsy; Female; Humans; Hyperandrogenism; Insuli

2000
Gas chromatography/negative ion chemical ionization mass spectrometry and liquid chromatography/electrospray ionization tandem mass spectrometry quantitative profiling of N-acetylcysteine conjugates of valproic acid in urine: application in drug metabolis
    Journal of mass spectrometry : JMS, 2000, Volume: 35, Issue:6

    Topics: Acetylcysteine; Adolescent; Analysis of Variance; Animals; Anticonvulsants; Child; Child, Preschool;

2000
N(6)-2-(4-aminophenyl)ethyl-adenosine enhances the anticonvulsive action of conventional antiepileptic drugs in the kindling model of epilepsy in rats.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2000, Volume: 10, Issue:4

    Topics: Adenosine; Amygdala; Animals; Anticonvulsants; Avoidance Learning; Carbamazepine; Disease Models, An

2000
A clinical study of 57 children with fetal anticonvulsant syndromes.
    Journal of medical genetics, 2000, Volume: 37, Issue:7

    Topics: Abnormalities, Drug-Induced; Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Ep

2000
Valproate, hyperandrogenism, and polycystic ovaries: a report of 3 cases.
    Archives of neurology, 2000, Volume: 57, Issue:7

    Topics: Adolescent; Adult; Anticonvulsants; Body Weight; Electroencephalography; Epilepsy; Female; Humans; H

2000
Sleep and epilepsy: A key role for nitric oxide?
    Epilepsia, 2000, Volume: 41, Issue:7

    Topics: Animals; Anticonvulsants; Brain; Cerebral Cortex; Circadian Rhythm; Disease Models, Animal; Electroe

2000
[Antiepileptic drugs and carnitine].
    Revista de neurologia, 2000, Volume: 30 Suppl 1

    Topics: Adolescent; Anticonvulsants; Carnitine; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; M

2000
Prognosis of seizures occurring in the first year.
    Pediatric neurology, 2000, Volume: 22, Issue:5

    Topics: Anticonvulsants; Brain; Child, Preschool; Developmental Disabilities; Diagnosis, Differential; Elect

2000
The effects on lipid and apolipoprotein serum levels of long-term carbamazepine, valproic acid and phenobarbital therapy in children with epilepsy.
    Epilepsy research, 2000, Volume: 41, Issue:1

    Topics: Anticonvulsants; Apolipoprotein A-I; Apolipoproteins; Apolipoproteins B; Carbamazepine; Child; Chole

2000
Liver transplantation: to do or not to do?
    Pediatric transplantation, 2000, Volume: 4, Issue:3

    Topics: Anticonvulsants; Child; Contraindications; Diffuse Cerebral Sclerosis of Schilder; Epilepsy; Female;

2000
Fatal deterioration of neurological disease after orthotopic liver transplantation for valproic acid-induced liver damage.
    Pediatric transplantation, 2000, Volume: 4, Issue:3

    Topics: Adolescent; Anticonvulsants; Diffuse Cerebral Sclerosis of Schilder; Electroencephalography; Epileps

2000
[A case with symptomatic epilepsy and mirror movement due to unilateral schizencephaly].
    No to shinkei = Brain and nerve, 2000, Volume: 52, Issue:7

    Topics: Anticonvulsants; Brain; Epilepsy; Functional Laterality; Humans; Male; Middle Aged; Movement Disorde

2000
Pathomorphological changes in mouse liver and kidney during prolonged valproate administration.
    International journal of tissue reactions, 2000, Volume: 22, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Epilepsy; Kidney; Kid

2000
Polycystic ovary syndrome in patients with focal epilepsy: a study in 93 women.
    Epilepsy research, 2000, Volume: 41, Issue:2

    Topics: Adult; Amenorrhea; Anticonvulsants; Carbamazepine; Cohort Studies; Drug Therapy, Combination; Epilep

2000
Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 294, Issue:3

    Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Enzyme Inhibitors; Epilepsy

2000
Decrease of valproic acid concentration in the blood when coprescribed with fluoxetine.
    Journal of clinical psychopharmacology, 1997, Volume: 17, Issue:2

    Topics: Aged; Aged, 80 and over; Anticonvulsants; Antidepressive Agents, Second-Generation; Depressive Disor

1997
Neonatal hypoglycaemia and withdrawal symptoms after exposure in utero to valproate.
    Archives of disease in childhood. Fetal and neonatal edition, 2000, Volume: 83, Issue:2

    Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Hypoglycemia; I

2000
Molecular regulation of glutamate and GABA transporter proteins by valproic acid in rat hippocampus during epileptogenesis.
    Experimental brain research, 2000, Volume: 133, Issue:3

    Topics: Amino Acid Transport System X-AG; Animals; Anticonvulsants; ATP-Binding Cassette Transporters; Carri

2000
Population based, prospective study of the care of women with epilepsy in pregnancy.
    BMJ (Clinical research ed.), 2000, Sep-16, Volume: 321, Issue:7262

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fetal Death; Guidelin

2000
Inhibition of neuronal hypersynchrony in vitro differentiates levetiracetam from classical antiepileptic drugs.
    Pharmacological research, 2000, Volume: 42, Issue:4

    Topics: Animals; Anticonvulsants; Calcium; Carbamazepine; Clonazepam; Electrophysiology; Epilepsy; Evoked Po

2000
Treatment of comorbid bipolar disorder and epilepsy with valproate.
    The Journal of neuropsychiatry and clinical neurosciences, 2000,Spring, Volume: 12, Issue:2

    Topics: Anticonvulsants; Bipolar Disorder; Epilepsy; Humans; Valproic Acid

2000
Carbamazepine and valproic acid: effects on the serum lipids and liver functions in children.
    Pediatric neurology, 2000, Volume: 23, Issue:2

    Topics: Adolescent; Analysis of Variance; Anticonvulsants; Carbamazepine; Chi-Square Distribution; Child; Ch

2000
Current perception thresholds of epileptic patients treated with valproate.
    Seizure, 2000, Volume: 9, Issue:7

    Topics: Adolescent; Adult; Anticonvulsants; Case-Control Studies; Epilepsy; Epilepsy, Post-Traumatic; Humans

2000
Effects of combined administration of zonisamide and valproic acid or phenytoin to nitric oxide production, monoamines and zonisamide concentrations in the brain of seizure-susceptible EL mice.
    Brain research bulletin, 2000, Sep-15, Volume: 53, Issue:2

    Topics: Animals; Anticonvulsants; Biogenic Monoamines; Brain; Disease Models, Animal; Drug Interactions; Dru

2000
The role of tiagabine in the treatment of intractable epilepsy of childhood with multifocal independent spikes: a case report.
    Clinical EEG (electroencephalography), 2000, Volume: 31, Issue:4

    Topics: Anticonvulsants; Brain; Child; Drug Therapy, Combination; Electroencephalography; Epilepsy; Humans;

2000
Renal tubular function in patients receiving anticonvulsant therapy: a long-term study.
    Epilepsia, 2000, Volume: 41, Issue:11

    Topics: Adolescent; Age Factors; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Follow-Up Studies;

2000
Serum sex hormone levels in young male patients with epilepsy receiving carbamazepine and valproic acid and after their withdrawal.
    European journal of pediatrics, 2000, Volume: 159, Issue:11

    Topics: Adolescent; Antidepressive Agents; Carbamazepine; Epilepsy; Gonadal Steroid Hormones; Humans; Male;

2000
Probenecid-inhibitable efflux transport of valproic acid in the brain parenchymal cells of rabbits: a microdialysis study.
    Brain research, 2000, Nov-24, Volume: 884, Issue:1--2

    Topics: Animals; Biological Transport, Active; Blood-Brain Barrier; Brain; Carrier Proteins; Cell Membrane;

2000
Valproate prevents epileptiform activity after trauma in an in vitro model in neocortical slices.
    Epilepsia, 2000, Volume: 41, Issue:12

    Topics: Animals; Anticonvulsants; Brain Injuries; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid;

2000
Effects of antiepileptic drugs on evoked potentials in epileptic children.
    Pediatric neurology, 2000, Volume: 23, Issue:5

    Topics: Adolescent; Adult; Analysis of Variance; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Ep

2000
Assessment of drug concentrations in tears in therapeutic drug monitoring: I. Determination of valproic acid in tears by gas chromatography/mass spectrometry with EC/NCI mode.
    Therapeutic drug monitoring, 2000, Volume: 22, Issue:6

    Topics: Anticonvulsants; Calibration; Drug Monitoring; Epilepsy; Gas Chromatography-Mass Spectrometry; Human

2000
Independent short-term variability of spike-like (600 Hz) and postsynaptic (N20) cerebral SEP components.
    Neuroreport, 2001, Feb-12, Volume: 12, Issue:2

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Arousal; Carbamazepine; Cerebral Cortex; Epilepsy; Evoked

2001
[Febrile pleuropericarditis during valproic acid treatment].
    Presse medicale (Paris, France : 1983), 2001, Jan-20, Volume: 30, Issue:2

    Topics: Anticonvulsants; Epilepsy; Female; Fever; Humans; Middle Aged; Pericarditis; Pleural Effusion; Valpr

2001
Valproate treatment and the risk of hyperandrogenism and polycystic ovaries.
    Bipolar disorders, 2000, Volume: 2, Issue:1

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Hyperandrogenism; Polycystic Ovary Syndrome; Risk

2000
Comparison the cognitive effect of anti-epileptic drugs in seizure-free children with epilepsy before and after drug withdrawal.
    Epilepsy research, 2001, Volume: 44, Issue:1

    Topics: Anticonvulsants; Carbamazepine; Child; Cognition; Epilepsy; Event-Related Potentials, P300; Female;

2001
Fetal valproate syndrome and autism: additional evidence of an association.
    Developmental medicine and child neurology, 2001, Volume: 43, Issue:3

    Topics: Autistic Disorder; Child; Child, Preschool; Developmental Disabilities; Epilepsy; Female; Follow-Up

2001
Increased urinary excretion of tubular enzymes and proteins in children with epilepsy.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2000, Volume: 4, Issue:6

    Topics: Acetylglucosaminidase; Adolescent; Alpha-Globulins; Anticonvulsants; Carbamazepine; Child; Child, Pr

2000
The teratogenicity of anticonvulsant drugs.
    The New England journal of medicine, 2001, Apr-12, Volume: 344, Issue:15

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Case-Control Studies; Congenital Abnorm

2001
Nitroso-urea-cisplatin-based chemotherapy associated with valproate: increase of haematologic toxicity.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2001, Volume: 12, Issue:2

    Topics: Adult; Aged; Anticonvulsants; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cispl

2001
Pharmacokinetic interactions among phenobarbital, carbamazepine, and valproic acid in pediatric Japanese patients: clinical considerations on steady-state serum concentration-dose ratios.
    American journal of therapeutics, 2000, Volume: 7, Issue:5

    Topics: Adolescent; Anticonvulsants; Biological Availability; Carbamazepine; Child; Dose-Response Relationsh

2000
Antiepileptic drug therapy and its management in sudden unexpected death in epilepsy: a case-control study.
    Epilepsia, 2001, Volume: 42, Issue:5

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Cohort Studies; Death, Sudd

2001
Latent coeliac disease in a child with epilepsy, cerebral calcifications, drug-induced systemic lupus erythematosus and intestinal folic acid malabsorption associated with impairment of folic acid transport across the blood-brain barrier.
    European journal of pediatrics, 2001, Volume: 160, Issue:5

    Topics: Adolescent; Anticonvulsants; Biological Transport; Blood-Brain Barrier; Brain; Brain Diseases; Calci

2001
Effect of Antiepileptic drugs on plasma lipoprotein (a) and other lipid levels in childhood.
    Journal of child neurology, 2001, Volume: 16, Issue:5

    Topics: Adolescent; Analysis of Variance; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cholester

2001
Repeated neural tube defects and valproate monotherapy suggest a pharmacogenetic abnormality.
    Epilepsia, 2001, Volume: 42, Issue:6

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Genetic Predisposition to Disease; Gravidity; Humans; Neur

2001
Case reports.
    Seizure, 2001, Volume: 10, Issue:3

    Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Anticonvulsants; Child; Diagnosis, Differential; Epileps

2001
Gender- or age-related binding characteristics of valproic acid to serum proteins in adult patients with epilepsy.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2001, Volume: 52, Issue:1

    Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Blood Proteins; Epilepsy; Female; Humans; Mal

2001
Valproate and the polycystic ovarian syndrome: final thoughts.
    Epilepsia, 2001, Volume: 42, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Comorbidity; Epilepsy; Female; Humans; Middle Aged; Polycystic O

2001
Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy.
    Epilepsia, 2001, Volume: 42, Issue:3

    Topics: Allosteric Regulation; Animals; Anticonvulsants; Benzodiazepinones; Desoxycorticosterone; Diazepam;

2001
Absence epilepsy with fast rhythmic discharges during sleep: an intermediary form of generalized epilepsy?
    Epilepsia, 2001, Volume: 42, Issue:3

    Topics: Adult; Age of Onset; Anticonvulsants; Cerebral Cortex; Child; Child, Preschool; Diagnosis, Different

2001
Severe, isolated thrombocytopenia under polytherapy with carbamazepine and valproate.
    Psychiatry and clinical neurosciences, 2001, Volume: 55, Issue:4

    Topics: Aged; Anticonvulsants; Blood Platelets; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female;

2001
Characterization of reproductive endocrine disorders in women with epilepsy.
    The Journal of clinical endocrinology and metabolism, 2001, Volume: 86, Issue:7

    Topics: Adolescent; Adult; Amenorrhea; Anticonvulsants; Endocrine System Diseases; Epilepsy; Female; Humans;

2001
Thyroid hormones in epileptic children receiving carbamazepine and valproic acid.
    Pediatric neurology, 2001, Volume: 25, Issue:1

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Case-Control Studies; Child; Drug Interactions; Drug The

2001
Thyroid function in men taking carbamazepine, oxcarbazepine, or valproate for epilepsy.
    Epilepsia, 2001, Volume: 42, Issue:7

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Enzyme Induction; Epilepsy; gamma-Glutamyltransfe

2001
Epilepsy.
    The New England journal of medicine, 2001, Aug-09, Volume: 345, Issue:6

    Topics: Anticonvulsants; Automobile Driving; Epilepsy; Female; Guidelines as Topic; Humans; Phenytoin; Valpr

2001
Early hormonal changes during valproate or carbamazepine treatment: a 3-month study.
    Neurology, 2001, Aug-14, Volume: 57, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Hormones; Humans; Male; Time Fa

2001
Decreased bone mass and increased bone turnover with valproate therapy in adults with epilepsy.
    Neurology, 2001, Aug-14, Volume: 57, Issue:3

    Topics: Adult; Anticonvulsants; Bone and Bones; Bone Density; Epilepsy; Female; Humans; Male; Middle Aged; V

2001
Weight change associated with valproate and lamotrigine monotherapy in patients with epilepsy.
    Neurology, 2001, Aug-14, Volume: 57, Issue:3

    Topics: Anticonvulsants; Body Weight; Epilepsy; Humans; Triazines; Valproic Acid

2001
[Depakene (sodium valproate) in the treatment of epilepsy in children and adolescents: efficiency and safety].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2001, Volume: 101, Issue:6

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Administration Schedule; Epilepsy;

2001
[The dangers of valproate in women].
    Duodecim; laaketieteellinen aikakauskirja, 1998, Volume: 114, Issue:9

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cholesterol, HDL; Epilepsy; Female; Humans; Hyperandro

1998
Hormone profiles in young adults with epilepsy treated with sodium valproate or lamotrigine monotherapy.
    Epilepsia, 2001, Volume: 42, Issue:8

    Topics: Adult; Anticonvulsants; Blood Glucose; Body Mass Index; Comorbidity; Dehydroepiandrosterone; Epileps

2001
Are serum anticonvulsant levels in people with epilepsy appropriately monitored?
    Journal of evaluation in clinical practice, 2001, Volume: 7, Issue:3

    Topics: Anticonvulsants; Drug Monitoring; Epilepsy; Humans; Logistic Models; Phenytoin; Valproic Acid

2001
Altered ovarian function and cardiovascular risk factors in valproate-treated women.
    The American journal of medicine, 2001, Volume: 111, Issue:4

    Topics: Adult; Analysis of Variance; Anticonvulsants; Carbamazepine; Cardiovascular Diseases; Case-Control S

2001
Long-term valproate and lamotrigine treatment may be a marker for reduced growth and bone mass in children with epilepsy.
    Epilepsia, 2001, Volume: 42, Issue:9

    Topics: Adolescent; Anticonvulsants; Bone and Bones; Bone Density; Bone Diseases, Developmental; Bone Diseas

2001
[Fatal necro-hemorrhagic pancreatitis related to sodium valproate: case report].
    Arquivos de neuro-psiquiatria, 2001, Volume: 59, Issue:3-B

    Topics: Acute Disease; Anticonvulsants; Child; Epilepsy; Fatal Outcome; Humans; Male; Necrosis; Pancreatitis

2001
Craniosynostosis and fetal exposure to sodium valproate.
    Journal of neurosurgery, 2001, Volume: 95, Issue:5

    Topics: Anticonvulsants; Child; Child, Preschool; Craniosynostoses; Epilepsy; Female; Fetus; Humans; Infant;

2001
[Analogs of generic preparations for the treatment of epilepsy: is their use safe?].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2001, Volume: 101, Issue:10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Child; Child, Preschool;

2001
Analysis of the musculoskeletal system in children and adolescents receiving anticonvulsant monotherapy with valproic acid or carbamazepine.
    Pediatrics, 2001, Volume: 108, Issue:6

    Topics: Adolescent; Alkaline Phosphatase; Amino Acids; Anticonvulsants; Biomarkers; Bone Density; Bone Resor

2001
Effectiveness of first antiepileptic drug.
    Epilepsia, 2001, Volume: 42, Issue:10

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Dose-Response Relationship, Drug; Electroe

2001
Fatal cardiac malformation in fetal valproate syndrome.
    Indian journal of pediatrics, 2001, Volume: 68, Issue:10

    Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Epilepsy; Fatal Outcome; Female; Heart Defects,

2001
[The pharmacological and hormonal effects of carbamazepine and valproic acid in the treatment of reproductive age women with epilepsy].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2001, Volume: 101, Issue:11

    Topics: Adult; Anticonvulsants; Carbamazepine; Endocrine System Diseases; Epilepsy; Estradiol; Female; Folli

2001
Methsuximide reduces valproic acid serum levels.
    Therapeutic drug monitoring, 2001, Volume: 23, Issue:6

    Topics: Adolescent; Adult; Anticonvulsants; Child; Drug Interactions; Epilepsy; Female; Humans; Male; Succin

2001
Serum copper, zinc, selenium, glutathione peroxidase and superoxide dismutase levels in epileptic children before and after 1 year of sodium valproate and carbamazepine therapy.
    Epilepsy research, 2002, Volume: 48, Issue:1-2

    Topics: Adolescent; Analysis of Variance; Anticonvulsants; Carbamazepine; Copper; Epilepsy; Female; Glutathi

2002
Hyperandrogenism, postprandial hyperinsulinism and the risk of PCOS in a cross sectional study of women with epilepsy treated with valproate.
    Epilepsy research, 2002, Volume: 48, Issue:1-2

    Topics: Adult; Anticonvulsants; Body Mass Index; Body Weight; Confidence Intervals; Cross-Sectional Studies;

2002
Effect of anticonvulsant drugs on interleukins-1, -2 and -6 and monocyte chemoattractant protein-1.
    Clinical and experimental medicine, 2001, Volume: 1, Issue:3

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Chemokine CCL2; Child; Epilepsy; Female; Humans; Interle

2001
Effect of L-carnitine treatment for valproate-induced hepatotoxicity.
    Neurology, 2002, Feb-12, Volume: 58, Issue:3

    Topics: Anticonvulsants; Carnitine; Chemical and Drug Induced Liver Injury; Epilepsy; Humans; Liver Diseases

2002
Tricarboxylic acid cycle of glia in the in vivo human brain.
    NMR in biomedicine, 2002, Volume: 15, Issue:1

    Topics: Acetates; Adult; Bicarbonates; Brain; Carbon Isotopes; Citric Acid Cycle; Epilepsy; Female; Glutamic

2002
[Pharmacokinetic aspects of carbamazepine and valproic acid using in reproductive-age women with epilepsy].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2002, Volume: 102, Issue:1

    Topics: Adult; Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Epilepsy; Female; Ferti

2002
Serum lipid changes during anticonvulsive treatment serum lipids in epileptic children.
    Acta neurologica Belgica, 2001, Volume: 101, Issue:4

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cholesterol; Cholesterol, HDL;

2001
[Monitoring of renal function in epileptic children and teenagers treated with valproic acid or carbamazepine in concomitant therapy with tiagabine].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2001, Volume: 11, Issue:66

    Topics: Acetylglucosaminidase; Adolescent; Adult; Anticonvulsants; beta 2-Microglobulin; Carbamazepine; Case

2001
Coagulation abnormalities and acquired von Willebrand's disease type 1 in children receiving valproic acid.
    Journal of child neurology, 2002, Volume: 17, Issue:1

    Topics: Adolescent; Anticonvulsants; Antigens; Blood Coagulation Tests; Child; Child, Preschool; Dose-Respon

2002
[Treatment of newly diagnosed epileptic crises. A French experience].
    Revue neurologique, 2001, Volume: 157, Issue:12

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Child; Child, Preschool;

2001
[Treatment of epileptic seizures resistant to phenobarbital in children during the first year of life].
    Likars'ka sprava, 2002, Issue:1

    Topics: Anticonvulsants; Drug Resistance; Epilepsy; Humans; Infant; Phenobarbital; Prospective Studies; Seiz

2002
Coma probably induced by lorazepam-valproate interaction.
    Seizure, 2002, Volume: 11, Issue:2

    Topics: Adult; Anticonvulsants; Coma; Drug Interactions; Epilepsy; Female; Humans; Lorazepam; Valproic Acid

2002
Topiramate enhances the risk of valproate-associated side effects in three children.
    Epilepsia, 2002, Volume: 43, Issue:4

    Topics: Affective Symptoms; Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Therapy, Combinati

2002
Pancreatitis complicating treatment with intravenous valproic acid.
    Journal of neurology, 2002, Volume: 249, Issue:4

    Topics: Adult; Aged; Epilepsy; Female; Humans; Injections, Intravenous; Male; Middle Aged; Pancreatitis; Val

2002
Bone mineral status in ambulatory pediatric patients on long-term anti-epileptic drug therapy.
    Pediatrics international : official journal of the Japan Pediatric Society, 2002, Volume: 44, Issue:3

    Topics: Absorptiometry, Photon; Adolescent; Anticonvulsants; Biomarkers; Bone Density; Bone Diseases, Metabo

2002
[Visual field defect in a patient given sodium valporate then carbamazepine: possible effect of aminotransferase inhibition].
    Revue neurologique, 2002, Volume: 158, Issue:4

    Topics: Adult; Amino Acid Metabolism, Inborn Errors; Anticonvulsants; Carbamazepine; Drug Therapy, Combinati

2002
Ophthalmic findings in fetal anticonvulsant syndrome(s).
    Ophthalmology, 2002, Volume: 109, Issue:5

    Topics: Abnormalities, Drug-Induced; Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Ep

2002
Reversible valproate-induced choreiform movements.
    Seizure, 2002, Volume: 11, Issue:3

    Topics: Adult; Anticonvulsants; Chorea; Craniocerebral Trauma; Epilepsy; Humans; Male; Time Factors; Valproi

2002
Do structural properties explain the anticonvulsant activity of valproate metabolites? A QSAR analysis.
    Epilepsia, 2002, Volume: 43, Issue:5

    Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Epilepsy; Humans; Isomerism; Male; Mice; Quantitative

2002
Serum insulin and leptin levels in valproate-associated obesity.
    Epilepsia, 2002, Volume: 43, Issue:5

    Topics: Adult; Body Mass Index; Body Weight; Epilepsy; Female; Humans; Insulin; Insulin Resistance; Leptin;

2002
Valproic acid and risperidone.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2002, Volume: 41, Issue:6

    Topics: Adolescent; Anticonvulsants; Antipsychotic Agents; Drug Interactions; Epilepsy; Female; Humans; Psyc

2002
Insulin resistance in epileptic girls who gain weight after therapy with valproic acid.
    Journal of child neurology, 2002, Volume: 17, Issue:4

    Topics: Androgens; Anticonvulsants; Blood Glucose; Body Mass Index; Child; Epilepsy; Female; Follicle Stimul

2002
Visual functions in epilepsy patients on valproate monotherapy.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2002, Volume: 9, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Electroretinography; Epilepsy; Female; Humans; Male; Reference V

2002
Deepening coma in an epileptic patient: the missing link to the urea cycle. Hyperammonaemic metabolic encephalopathy.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2002, Volume: 17, Issue:7

    Topics: Anticonvulsants; Atrophy; Cerebellum; Coma; Epilepsy; Female; Humans; Hyperammonemia; Middle Aged; T

2002
[Adverse effects of anti-epileptic drugs].
    Deutsche medizinische Wochenschrift (1946), 1975, Sep-19, Volume: 100, Issue:38

    Topics: Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Carbamazepine; Diazepam; Epilepsy; Ethos

1975
Prognosis and therapy of complex partial seizures with barbiturates, hydantoins, and other drugs.
    Advances in neurology, 1975, Volume: 11

    Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Drug Therapy, Combination; Epilepsy; Epilepsy, Tempo

1975
Use of anticonvulsant drugs.
    JAMA, 1979, Feb-09, Volume: 241, Issue:6

    Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Epilepsy; Ethosuximide; Humans; Phenobarbital

1979
Proceedings: Sodium valproate (Epilim) and photosensitivity. A preliminary report.
    Electroencephalography and clinical neurophysiology, 1975, Volume: 39, Issue:4

    Topics: Electroencephalography; Epilepsy; Humans; Valerates; Valproic Acid

1975
Proceedings: Sodium valproate (Epilim) in the treatment of intractable epilepsy, including some observations on blood levels.
    Electroencephalography and clinical neurophysiology, 1975, Volume: 39, Issue:4

    Topics: Epilepsy; Humans; Valerates; Valproic Acid

1975
Proceedings: The effect of sodium valproate (Epilim) on the EEG.
    Electroencephalography and clinical neurophysiology, 1975, Volume: 39, Issue:4

    Topics: Electroencephalography; Epilepsy; Humans; Valerates; Valproic Acid

1975
Letter: Valproate in the U.S.A.
    Lancet (London, England), 1976, Jun-19, Volume: 1, Issue:7973

    Topics: Drug and Narcotic Control; Drug Industry; Epilepsy; Humans; United States; Valerates; Valproic Acid

1976
Valproate may lower serum-phenytoin.
    Lancet (London, England), 1976, Dec-11, Volume: 2, Issue:7998

    Topics: Drug Interactions; Epilepsy; Humans; Phenytoin; Valerates; Valproic Acid

1976
Dipropylacetate (valproate) and glycine metabolism.
    Lancet (London, England), 1977, Sep-17, Volume: 2, Issue:8038

    Topics: Epilepsy; Glycine; Humans; Infant; Valerates; Valproic Acid

1977
Sodium valproate in epilepsy.
    Lancet (London, England), 1977, Oct-22, Volume: 2, Issue:8043

    Topics: Drug Evaluation; Epilepsy; Humans; Valerates; Valproic Acid

1977
Sodium valproate and platelet-count.
    Lancet (London, England), 1978, Mar-25, Volume: 1, Issue:8065

    Topics: Child; Epilepsy; Female; Humans; Male; Thrombocytopenia; Valerates; Valproic Acid

1978
Effects of anticonvulsant drugs on thyroid hormones in epileptic children.
    Epilepsia, 1978, Volume: 19, Issue:4

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Cholesterol; Dose-Response Relationship, Drug; Dr

1978
Lowered erythrocyte-sedimentation rate with sodium valproate.
    Lancet (London, England), 1978, Dec-16, Volume: 2, Issue:8103

    Topics: Afibrinogenemia; Blood Sedimentation; Epilepsy; Humans; Valproic Acid

1978
Treatment of childhood epilepsy with dipropylacetic acid (DPA).
    Archiv fur Psychiatrie und Nervenkrankheiten, 1978, Oct-09, Volume: 226, Issue:1

    Topics: Adolescent; Adult; Child; Child, Preschool; Electroencephalography; Epilepsies, Myoclonic; Epilepsy;

1978
Sodium valproate (Epilim) in epilepsy: a trial.
    The New Zealand medical journal, 1978, Dec-27, Volume: 88, Issue:626

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Cloni

1978
Clinical efficacy of valproic acid in relation to plasma levels.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1978, Volume: 5, Issue:4

    Topics: Adolescent; Adult; Epilepsies, Myoclonic; Epilepsy; Epilepsy, Absence; Female; Humans; Male; Valproi

1978
Pattern sensitive epilepsy: a case report.
    Journal of neurology, neurosurgery, and psychiatry, 1979, Volume: 42, Issue:7

    Topics: Child; Electroencephalography; Epilepsy; Epilepsy, Absence; Female; Form Perception; Humans; Light;

1979
Macaca fascicularis: alternative epileptic model.
    Life sciences, 1979, Jul-16, Volume: 25, Issue:3

    Topics: Animals; Brain; Disease Models, Animal; Electroencephalography; Epilepsy; Haplorhini; Macaca; Macaca

1979
Sodium valproate.
    The New Zealand medical journal, 1979, Oct-10, Volume: 90, Issue:645

    Topics: Adult; Animals; Brain; Child; Epilepsy; Epilepsy, Absence; Female; Hemostasis; Humans; Pregnancy; Va

1979
Sodium valproate and hepatotoxicity in epileptics.
    The Medical journal of Australia, 1979, Dec-01, Volume: 2, Issue:11

    Topics: Adolescent; Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Child; Drug Therapy, Com

1979
Acute intoxication with sodium valproate.
    Annals of neurology, 1979, Volume: 6, Issue:6

    Topics: Acute Disease; Adolescent; Adult; Brain Diseases; Epilepsy; Female; Humans; Male; Valproic Acid

1979
Sodium valproate, pregnancy, and neonatal hyperglycinaemia.
    Archives of disease in childhood, 1979, Volume: 54, Issue:12

    Topics: Adult; Epilepsy; Female; Glycine; Humans; Infant, Newborn; Infant, Newborn, Diseases; Pregnancy; Pre

1979
Comparative steady state serum levels of valproic acid administered as two different formulations--Deprakine and Orfiril.
    Acta neurologica Scandinavica, 1979, Volume: 60, Issue:6

    Topics: Absorption; Adolescent; Adult; Biological Availability; Epilepsy; Female; Gastric Mucosa; Humans; Ma

1979
Some aspects of the clinical use of clonazepam in refractory epilepsy.
    Clinical and experimental neurology, 1979, Volume: 16

    Topics: Adolescent; Adult; Ataxia; Benzodiazepinones; Child; Clonazepam; Depression; Drug Therapy, Combinati

1979
[Domestically produced sodium n-dipropylacetate in treating epilepsy (author's transl)].
    Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry, 1979, Volume: 12, Issue:4

    Topics: Adolescent; Adult; Brain Chemistry; Child; Child, Preschool; Epilepsy; Female; gamma-Aminobutyric Ac

1979
Valproic acid-phenytoin interaction.
    Therapeutic drug monitoring, 1979, Volume: 1, Issue:2

    Topics: Adult; Chromatography, Gas; Drug Interactions; Epilepsy; Humans; Monitoring, Physiologic; Phenytoin;

1979
[Antiepileptic therapy with valproinic acid. Correlations of side effects and serum levels of valproinic acid].
    Fortschritte der Medizin, 1979, Sep-13, Volume: 97, Issue:34

    Topics: Acne Vulgaris; Anemia, Aplastic; Epilepsy; Fatigue; Gastrointestinal Diseases; Humans; Leukopenia; T

1979
[Drug therapy of epilepsy].
    Der Internist, 1977, Volume: 18, Issue:2

    Topics: Age Factors; Anticonvulsants; Barbiturates; Benzodiazepines; Bromides; Carbamazepine; Chlormethiazol

1977
Drug interactions during anticonvulsant therapy in childhood: diphenylhydantoin, primidone, phenobarbitone, clonazepam, nitrazepam, carbamazepin and dipropylacetate.
    Neuropadiatrie, 1977, Volume: 8, Issue:1

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Drug Interactions;

1977
Early experience with sodium valproate.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1977, Feb-26, Volume: 51, Issue:9

    Topics: Epilepsy; Humans; Valerates; Valproic Acid

1977
Management of childhood epilepsy.
    British medical journal, 1977, Apr-16, Volume: 1, Issue:6067

    Topics: Child; Epilepsy; Humans; Phenobarbital; Phenytoin; Valproic Acid

1977
Implications of measuring anticonvulsant blood levels in epilepsy.
    Developmental medicine and child neurology, 1977, Volume: 19, Issue:2

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Epilepsy; Humans; Middle Aged; Patient Compliance;

1977
[Study of the immunosuppressive effect of some anticonvulsants in children].
    Minerva pediatrica, 1977, Apr-07, Volume: 29, Issue:12

    Topics: Adolescent; Anticonvulsants; B-Lymphocytes; Child; Child, Preschool; Epilepsy; Female; Humans; Immun

1977
Preliminary observations on valproic acid kinetics in patients with epilepsy.
    Arzneimittel-Forschung, 1977, Volume: 27, Issue:5

    Topics: Adult; Child; Chromatography, Gas; Epilepsy; Humans; Phenobarbital; Phenytoin; Valerates; Valproic A

1977
Pharmacokinetic studies with valproic acid in man.
    Arzneimittel-Forschung, 1977, Volume: 27, Issue:5

    Topics: Adult; Child; Child, Preschool; Chromatography, Gas; Epilepsy; Extracellular Space; Half-Life; Human

1977
[Studies on the urinary excretion of metabolites of valproic acid (dipropylacetic acid) in rats and humans (author's transl)].
    Arzneimittel-Forschung, 1977, Volume: 27, Issue:5

    Topics: Adipates; Animals; Epilepsy; Glutarates; Humans; Kidney; Malonates; Rats; Succinates; Valerates; Val

1977
[Thrombocyte values in adults during the treatment with DPA (Ergenyl)].
    Die Medizinische Welt, 1977, Jun-17, Volume: 28, Issue:24

    Topics: Adolescent; Adult; Blood Platelets; Dose-Response Relationship, Drug; Epilepsy; Humans; Middle Aged;

1977
Plasma levels of di-no-propylacetate and clonazepam in epileptic patients.
    International journal of clinical pharmacology and biopharmacy, 1977, Volume: 15, Issue:9

    Topics: Adolescent; Adult; Benzodiazepinones; Child; Clonazepam; Epilepsy; Female; Humans; Male; Valerates;

1977
Epilepsy and IgA deficiency--the effect of sodium valproate.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1977, Oct-08, Volume: 52, Issue:16

    Topics: Adult; Agammaglobulinemia; Carbamazepine; Epilepsy; Female; Humans; Immunoglobulin A; Male; Phenobar

1977
Choice of drug therapy in epilepsy.
    The Practitioner, 1977, Volume: 219, Issue:1312

    Topics: Acetazolamide; Anticonvulsants; Benzodiazepines; Carbamazepine; Clonazepam; Epilepsy; Ethosuximide;

1977
[Plasma levels of anticonvulsants. Experiences with routine plasma level determination of 6 different anticonvulsants].
    Fortschritte der Medizin, 1978, Jan-05, Volume: 96, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Epilepsy; Ethos

1978
[Study of the therapeutic action and side-effects of a new preparation of dipropylacetic acid].
    La Clinica terapeutica, 1977, Nov-15, Volume: 83, Issue:3

    Topics: Adolescent; Adult; Child; Epilepsy; Female; Gastrointestinal Diseases; Humans; Male; Valerates; Valp

1977
Serum protein binding of diphenylhydantoin in man. I. Interaction with sodium valproate.
    Il Farmaco; edizione pratica, 1978, Volume: 33, Issue:2

    Topics: Drug Interactions; Epilepsy; Humans; In Vitro Techniques; Phenytoin; Protein Binding; Valerates; Val

1978
Sodium valproate (Epilim) in the treatment of refractory epilepsy.
    The New Zealand medical journal, 1978, Jan-11, Volume: 87, Issue:603

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Interactions; Epilepsy; Female; Humans; M

1978
Steady-state kinetics of valproic acid in epileptic patients.
    Clinical pharmacology and therapeutics, 1978, Volume: 24, Issue:3

    Topics: Adolescent; Adult; Epilepsy; Female; Half-Life; Humans; Kinetics; Male; Models, Biological; Valproic

1978
A brief review of valproate. A new anticonvulsant.
    The Journal of the Maine Medical Association, 1978, Volume: 69, Issue:8

    Topics: Adolescent; Adult; Anticonvulsants; Child; Drug Evaluation; Epilepsy; Female; Humans; Male; Valproic

1978
Effect of valproic acid on hepatic function.
    Neurology, 1978, Volume: 28, Issue:9 Pt 1

    Topics: Adolescent; Adult; Alanine Transaminase; Aspartate Aminotransferases; Epilepsy; Female; Humans; Live

1978
Plasma sodium valproate levels and clinical response in epilepsy.
    Clinical and experimental neurology, 1977, Volume: 14

    Topics: Anticonvulsants; Drug Therapy, Combination; Epilepsy; Humans; Valproic Acid

1977
Long-term use of the major anticonvulsant drugs.
    American family physician, 1978, Volume: 18, Issue:4

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy; Ethosuximi

1978
Valproic acid: a brief review.
    The Ohio State medical journal, 1978, Volume: 74, Issue:10

    Topics: Dose-Response Relationship, Drug; Drug Evaluation; Epilepsy; Humans; Valproic Acid

1978
[Studies on the therapeutic scope of valproic acid].
    Die Medizinische Welt, 1979, Jan-12, Volume: 30, Issue:2

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Male; M

1979
Concomitant use of clonazepam and valproic acid in treatment of epileptic seizures.
    American journal of hospital pharmacy, 1979, Volume: 36, Issue:1

    Topics: Benzodiazepinones; Child; Clonazepam; Drug Therapy, Combination; Epilepsy; Humans; Male; Valproic Ac

1979
[Dipropylacetate (sodium valproate) and carbamazepine : a suspicious anticonvulsant combination].
    La Nouvelle presse medicale, 1978, Nov-25, Volume: 7, Issue:41

    Topics: Carbamazepine; Cognition Disorders; Confusion; Drug Therapy, Combination; Epilepsy; Humans; Male; Mi

1978
Valproic acid: a new antiepileptic agent.
    American family physician, 1979, Volume: 19, Issue:2

    Topics: Drug Interactions; Epilepsy; Humans; Valproic Acid

1979
A controlled study of the effect of sodium valproate on photosensitive epilepsy and its prognosis.
    Epilepsia, 1978, Volume: 19, Issue:6

    Topics: Adolescent; Adult; Child; Electroencephalography; Epilepsy; Evoked Potentials; Female; Follow-Up Stu

1978
Consensus on valproic acid: a versatile anticonvulsant.
    Hospital practice, 1978, Volume: 13, Issue:11

    Topics: Adolescent; Adult; Epilepsy; Humans; Middle Aged; Valproic Acid

1978
Drugs for epilepsy.
    The Medical letter on drugs and therapeutics, 1979, Mar-23, Volume: 21, Issue:6

    Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Epilepsy; Ethosuximide; Humans; Phenobarbital;

1979
Effects of valproate and ethosuximide on thalamocortical excitability.
    Neurology, 1979, Volume: 29, Issue:1

    Topics: Animals; Cats; Cerebral Cortex; Epilepsy; Ethosuximide; Thalamus; Valproic Acid

1979
Recent advances in drug therapy for epilepsy.
    Canadian Medical Association journal, 1979, Apr-07, Volume: 120, Issue:7

    Topics: Anticonvulsants; Carbamazepine; Clonazepam; Drug Interactions; Epilepsy; Humans; Phenobarbital; Phen

1979
Valproic acid in epilepsy.
    JAMA, 1979, May-04, Volume: 241, Issue:18

    Topics: Child; Epilepsy; Humans; Valproic Acid

1979
Acute hepatic failure associated with the use of sodium valproate.
    The New England journal of medicine, 1979, Apr-26, Volume: 300, Issue:17

    Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Epilepsy; Humans; Li

1979
Sodium valproate and pregnancy.
    Archives of disease in childhood, 1979, Volume: 54, Issue:3

    Topics: Adult; Breast Feeding; Epilepsy; Female; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Mil

1979
Epilepsy and learning.
    British medical journal, 1979, Mar-17, Volume: 1, Issue:6165

    Topics: Adolescent; Child; Epilepsy; Humans; Learning; Valproic Acid

1979
Side effects of sodium valproate (sodium di-N-propylacetate) on malonyldialdehyde-production and other platelet function tests.
    Minerva pediatrica, 1978, Sep-15, Volume: 30, Issue:17

    Topics: Adult; Blood Platelet Disorders; Blood Platelets; Child; Epilepsy; Factor IX; Factor VIII; Fibrinoge

1978
The use of antiepileptic drugs.
    Annals of internal medicine, 1979, Volume: 90, Issue:2

    Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Drug Interactions; Epilepsy; Ethosuximide; Humans;

1979
Comparative trial of valproate sodium and clonazepam in chronic epilepsy.
    Archives of neurology, 1979, Volume: 36, Issue:5

    Topics: Adult; Ataxia; Benzodiazepinones; Chronic Disease; Clonazepam; Drug Therapy, Combination; Epilepsy;

1979
"Epilim" in intractable epilepsy of childhood.
    The Central African journal of medicine, 1979, Volume: 25, Issue:3

    Topics: Child; Epilepsy; Humans; Valproic Acid

1979
[Valproate (dipropyl acetate)--a new-series antiepileptic drug].
    Ceskoslovenska pediatrie, 1979, Volume: 34, Issue:5

    Topics: Anticonvulsants; Chemical Phenomena; Chemistry; Drug Interactions; Epilepsy; Humans; Valproic Acid

1979
Serum protein binding of diphenylhydantoin in man. II. Interaction with sodium valproate in epileptic patients.
    Il Farmaco; edizione pratica, 1979, Volume: 34, Issue:1

    Topics: Adult; Binding, Competitive; Drug Interactions; Epilepsy; Female; Humans; Male; Middle Aged; Phenyto

1979
[Transitory medullary hypoplasia induced by sodium dipropylacetate (author's transl)].
    La Nouvelle presse medicale, 1979, Feb-17, Volume: 8, Issue:8

    Topics: Bone Marrow; Child; Epilepsy; Humans; Male; Pancytopenia; Purpura, Thrombocytopenic; Remission, Spon

1979
Combination of clonazepam and sodium valproate in the treatment of refractory epileptic seizures in 12 children.
    American journal of hospital pharmacy, 1979, Volume: 36, Issue:6

    Topics: Benzodiazepinones; Child; Clonazepam; Drug Therapy, Combination; Epilepsy; Humans; Seizures; Valproi

1979
A direct hepatotoxic effect of valproic acid.
    JAMA, 1979, Sep-14, Volume: 242, Issue:11

    Topics: Adolescent; Adult; Alkaline Phosphatase; Blood Coagulation Tests; Child; Dose-Response Relationship,

1979
Reye-like syndrome associated with valproic acid therapy.
    The Journal of pediatrics, 1979, Volume: 95, Issue:1

    Topics: Chemical and Drug Induced Liver Injury; Child; Epilepsy; Female; Humans; Reye Syndrome; Valproic Aci

1979
Lack of hepatic enzyme inducing effect of sodium valproate.
    British journal of clinical pharmacology, 1979, Volume: 8, Issue:2

    Topics: Adult; Antipyrine; Enzyme Induction; Epilepsy; Female; Glucaric Acid; Half-Life; Humans; Liver; Male

1979
Dipropylacetate and hyperglycinemia.
    Neuropadiatrie, 1979, Volume: 10, Issue:2

    Topics: Adolescent; Child; Epilepsy; Glycine; Humans; Valproic Acid

1979
Recent advances in drug therapy of some forms of childhood epilepsy.
    Paediatrician, 1979, Volume: 8 Suppl 1

    Topics: Anticonvulsants; Carbamazepine; Child; Clonazepam; Diazepam; Drug Therapy, Combination; Epilepsy; Hu

1979
Sodium valproate: dose-plasma level relationships and interdose fluctuations.
    Clinical and experimental neurology, 1978, Volume: 15

    Topics: Adolescent; Adult; Anticonvulsants; Child; Drug Therapy, Combination; Epilepsy; Female; Humans; Male

1978
Side effects of sodium valproate during long-term treatment in epilepsy.
    Acta neurologica Scandinavica, 1979, Volume: 60, Issue:2

    Topics: Adolescent; Adult; Aggression; Brain; Epilepsy; Female; Humans; Male; Middle Aged; Time Factors; Val

1979
Single and chronic dose pharmacokinetic studies of sodium valproate in epileptic patients.
    European journal of clinical pharmacology, 1979, Volume: 16, Issue:1

    Topics: Adult; Drug Interactions; Epilepsy; Half-Life; Humans; Kinetics; Male; Middle Aged; Time Factors; Va

1979
Simple gas-chromatographic measurement of valproic acid in psychiatric patients: effect on levels of other simultaneously administered anticonvulsants.
    Neuroscience letters, 1979, Volume: 11, Issue:3

    Topics: Adult; Anticonvulsants; Chromatography, Gas; Drug Therapy, Combination; Epilepsy; Humans; Middle Age

1979
Decreased plasma protein binding of phenytoin in patients on valproic acid.
    British journal of clinical pharmacology, 1979, Volume: 8, Issue:6

    Topics: Adolescent; Adult; Blood Proteins; Child; Creatinine; Depression, Chemical; Epilepsy; Humans; Phenyt

1979
Sodium valproate and clonazepam in the treatment of intractable epilepsy.
    Archives of neurology, 1977, Volume: 34, Issue:1

    Topics: Adolescent; Adult; Benzodiazepinones; Child; Clonazepam; Drug Evaluation; Epilepsy; Epilepsy, Absenc

1977
Treatment of generalized epilepsies of childhood and adolescence with sodium valproate ("epilim").
    Developmental medicine and child neurology, 1977, Volume: 19, Issue:1

    Topics: Adolescent; Automatism; Child; Drug Evaluation; Electroencephalography; Epilepsies, Myoclonic; Epile

1977
[The treatment of primary generalized epilepsies with dipropyl acetate (DPA)].
    Fortschritte der Medizin, 1977, Apr-07, Volume: 95, Issue:13

    Topics: Adolescent; Child; Child, Preschool; Drug Evaluation; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-C

1977
Sodium valproate for the treatment of childhood epilepsies.
    The Medical journal of Australia, 1977, Jan-22, Volume: 1, Issue:4

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Interactions; Epilepsies, Myoclonic; Epil

1977
The anticonvulsant action of sodium valproate (Epilim) in 100 patients with various forms of epilepsy.
    The Medical journal of Australia, 1977, Jun-18, Volume: 1, Issue:25

    Topics: Adolescent; Adult; Child; Epilepsies, Myoclonic; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lob

1977
[Clinical study of serum level of dipropylacetic acid sodium (Depakene) by gaschromatography (author's transl)].
    No to shinkei = Brain and nerve, 1977, Volume: 29, Issue:8

    Topics: Adolescent; Adult; Child; Child, Preschool; Chromatography, Gas; Drug Therapy, Combination; Epilepsi

1977
Sodium valproate in the treatment of intractable seizure disorders: a clinical and electroencephalographic study.
    Neurology, 1978, Volume: 28, Issue:2

    Topics: Adult; Drug Evaluation; Electroencephalography; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic;

1978
[Measurement of the blood concentration of antiepileptic drugs. II Special cases].
    La Nouvelle presse medicale, 1975, May-24, Volume: 4, Issue:21

    Topics: Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Epilepsy; Ethosuximide; Humans; Phenobarbi

1975
[Myoclonic cerebellar dyssynergia with epilepsy (Ramsey-Hunt syndrome). Electro-clinical study in a patient of the black race].
    Bulletin de la Societe medicale d'Afrique noire de langue francaise, 1975, Volume: 20, Issue:2

    Topics: Adult; Black People; Cerebellar Ataxia; Electroencephalography; Epilepsy; Female; Humans; Phenobarbi

1975
The use of sodium valproate in a case of status epilepticus.
    Developmental medicine and child neurology, 1976, Volume: 18, Issue:2

    Topics: Child; Epilepsy; Female; Humans; Intubation, Gastrointestinal; Nose; Valerates; Valproic Acid

1976
Pharmacokinetics of di-n-propylacetate in epileptic patients.
    European journal of clinical pharmacology, 1975, Feb-28, Volume: 8, Issue:2

    Topics: Administration, Oral; Aged; Body Weight; Child; Child, Preschool; Dose-Response Relationship, Drug;

1975
[Changes in hemostasis during epilespy treatment using dipropyl acetate. Extended study].
    Fortschritte der Medizin, 1976, Mar-11, Volume: 94, Issue:8

    Topics: Adolescent; Blood Cell Count; Blood Platelets; Child; Child, Preschool; Epilepsy; Factor IX; Female;

1976
Proposals on antiepileptic pharmacotherapy for use in developing countries.
    Epilepsia, 1976, Volume: 17, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Developing Countries; Diazepam

1976
The anticonvulsant effect of sodium valproate and clonazepam in the management of intractable epilepsy.
    Transactions of the American Neurological Association, 1976, Volume: 101

    Topics: Benzodiazepinones; Clonazepam; Drug Evaluation; Epilepsy; Humans; Valerates; Valproic Acid

1976
The treatment of childhood epilepsy with sodium valproate.
    Developmental medicine and child neurology, 1975, Volume: 17, Issue:6

    Topics: Adolescent; Child; Child, Preschool; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy,

1975
[Austrian complex-study on dipropylacetate. Pediatric experiences].
    Padiatrie und Padologie, 1976, Volume: 11, Issue:1

    Topics: Austria; Child; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Humans

1976
Sodium valproate in the management of intractable epilepsy: comparison with clonazepam.
    Proceedings of the Australian Association of Neurologists, 1975, Volume: 12

    Topics: Adolescent; Adult; Benzodiazepinones; Child; Clonazepam; Epilepsy; Epilepsy, Tonic-Clonic; Female; H

1975
Sodium valproate in the treatment of resistant epilepsy.
    Acta neurologica Scandinavica, 1976, Volume: 54, Issue:3

    Topics: Adolescent; Adult; Alopecia; Anticonvulsants; Body Weight; Diarrhea; Drug Interactions; Epilepsies,

1976
Early experience with sodium valproate.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1976, Nov-20, Volume: 50, Issue:50

    Topics: Adolescent; Adult; Child; Child, Preschool; Chronic Disease; Epilepsies, Partial; Epilepsy; Humans;

1976
[The effect of dipropyl acetic acid (Convules) in epileptic adults with a high frequency of seizures].
    Wiener klinische Wochenschrift, 1976, Dec-10, Volume: 88, Issue:23

    Topics: Adult; Aged; Barbiturates; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Epilepsy, Tonic-C

1976
Sodium valproate in the treatment of intractable childhood epilepsy.
    Developmental medicine and child neurology, 1975, Volume: 17, Issue:2

    Topics: Adolescent; Brain; Child; Child, Preschool; Drug Evaluation; Electroencephalography; Epilepsy; Human

1975
Letter: Preliminary experience with sodium valproate.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1975, Jun-28, Volume: 49, Issue:27

    Topics: Adolescent; Adult; Anticonvulsants; Child; Drug Therapy, Combination; Epilepsy; Female; Humans; Male

1975
[Thrombocyte values during ergenyl treatment].
    Bibliotheca psychiatrica, 1975, Issue:151

    Topics: Anticonvulsants; Blood Cell Count; Blood Platelets; Child; Child, Preschool; Epilepsy; Humans; Throm

1975
Letter: Sodium valproate in the treatment of intractable childhood epilepsy.
    Developmental medicine and child neurology, 1975, Volume: 17, Issue:4

    Topics: Diazepam; Drug Therapy, Combination; Epilepsy; Phenobarbital; Phenytoin; Primidone; Pyridoxine; Vale

1975
Elevation of diphenylhydantoin and primidone serum concentration by addition of dipropylacetate, a new anticonvulsant drug.
    Acta paediatrica Scandinavica, 1975, Volume: 64, Issue:5

    Topics: Child; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Phenytoin; Primidone; Valerat

1975
Sodium valproate and clonazepam for epilepsy.
    Drug and therapeutics bulletin, 1975, Dec-05, Volume: 13, Issue:25

    Topics: Adult; Benzodiazepinones; Child; Clonazepam; Epilepsy; Humans; Valproic Acid

1975
Concentration of dipropylacetate in plasma.
    Epilepsia, 1975, Volume: 16, Issue:4

    Topics: Administration, Oral; Dose-Response Relationship, Drug; Epilepsy; Humans; Time Factors; Valerates; V

1975
Influence of phenobarbital on ECoG phenomena induced by metrazol in rats during ontogenesis.
    Physiological research, 1992, Volume: 41, Issue:2

    Topics: Aging; Animals; Cerebral Cortex; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Dru

1992
Treatment of epilepsy.
    The Practitioner, 1992, Volume: 236, Issue:1519

    Topics: Adult; Carbamazepine; Epilepsy; Female; Humans; Male; Phenytoin; Valproic Acid

1992
Detection by HPLC-ICP of metallothionein in serum of an epileptic child with valproate-associated hepatotoxicity.
    Journal of trace elements and electrolytes in health and disease, 1992, Volume: 6, Issue:4

    Topics: Blood Proteins; Child; Chromatography, High Pressure Liquid; Copper; Epilepsy; Hepatic Encephalopath

1992
Cognitive functions, epileptic syndromes and antiepileptic drugs.
    Arquivos de neuro-psiquiatria, 1992, Volume: 50, Issue:1

    Topics: Adolescent; Adult; Carbamazepine; Child; Cognition; Epilepsy; Female; Humans; Male; Middle Aged; Phe

1992
Involvement of GABA-dependent chloride channel in the action of anticonvulsant and convulsant drugs.
    Epilepsy research. Supplement, 1992, Volume: 8

    Topics: Animals; Anticonvulsants; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebr

1992
What to do when the first anticonvulsant does not work.
    Seizure, 1992, Volume: 1, Issue:1

    Topics: Aminocaproates; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Lamotrigine; Phenytoin; Treatment

1992
Therapeutic drug monitoring improves seizure control and reduces anticonvulsant side-effects in patients with refractory epilepsy.
    Seizure, 1992, Volume: 1, Issue:4

    Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Monitoring; Electroencephalog

1992
Increased cortical excitability in generalised epilepsy demonstrated with transcranial magnetic stimulation.
    Lancet (London, England), 1992, Feb-08, Volume: 339, Issue:8789

    Topics: Cerebral Cortex; Electric Stimulation; Epilepsy; Humans; Seizures; Transcranial Magnetic Stimulation

1992
Sister-chromatid exchanges are increased in epileptics, but not by sodium valproate.
    Mutation research, 1992, Volume: 283, Issue:4

    Topics: Adolescent; Adult; Aged; Analysis of Variance; Child; Epilepsy; Humans; Leukocytes; Middle Aged; Mut

1992
Variability and clinical relevance of the interaction between sodium valproate and carbamazepine in epileptic patients.
    Epilepsy research, 1992, Volume: 11, Issue:3

    Topics: Adolescent; Adult; Carbamazepine; Cognition; Drug Interactions; Epilepsy; Female; Humans; Male; Midd

1992
Valproate acute administration, EEG epileptic abnormalities, and ammonemia.
    Neurology, 1992, Volume: 42, Issue:10

    Topics: Adolescent; Adult; Ammonia; Electroencephalography; Epilepsy; Female; Humans; Male; Valproic Acid

1992
The effect of anticonvulsants on EEG background activity in epileptic children with monopharmacy.
    The Japanese journal of psychiatry and neurology, 1992, Volume: 46, Issue:2

    Topics: Adolescent; Analysis of Variance; Carbamazepine; Child; Electroencephalography; Epilepsy; Humans; Va

1992
Increased aspartate release from brain slices of epileptic experimental animals and effect of valproate on it.
    The Japanese journal of psychiatry and neurology, 1992, Volume: 46, Issue:2

    Topics: Animals; Aspartic Acid; Brain; Disease Models, Animal; Epilepsy; In Vitro Techniques; Mice; Mice, Ne

1992
Changes in unbound and total valproic acid concentrations after replacement of carbamazepine with oxcarbazepine.
    Therapeutic drug monitoring, 1992, Volume: 14, Issue:5

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combinat

1992
Relationship between serum concentration and dose of valproic acid during monotherapy in adult outpatients.
    Therapeutic drug monitoring, 1992, Volume: 14, Issue:5

    Topics: Adult; Aged; Dose-Response Relationship, Drug; Epilepsy; Female; Genetic Variation; Humans; Male; Mi

1992
The disposition of valproate and its metabolites in the late first trimester and early second trimester of pregnancy in maternal serum, urine, and amniotic fluid: effect of dose, co-medication, and the presence of spina bifida.
    European journal of clinical pharmacology, 1992, Volume: 43, Issue:4

    Topics: Amniocentesis; Amniotic Fluid; Drug Therapy, Combination; Epilepsy; Female; Gas Chromatography-Mass

1992
Chromosome fragility in the Lennox-Gastaut epilepsy syndrome.
    Journal of intellectual disability research : JIDR, 1992, Volume: 36 ( Pt 5)

    Topics: Adolescent; Adult; Chromosome Aberrations; Chromosome Banding; Chromosome Fragile Sites; Chromosome

1992
Cerebral cavernous angioma: a potentially benign condition? Successful treatment in 16 cases.
    Journal of neurology, neurosurgery, and psychiatry, 1992, Volume: 55, Issue:11

    Topics: Adolescent; Adult; Angiography; Brain Neoplasms; Carbamazepine; Cerebral Hemorrhage; Child; Epilepsy

1992
Psychological effects of sodium valproate and carbamazepine in epilepsy.
    Archives of disease in childhood, 1992, Volume: 67, Issue:11

    Topics: Carbamazepine; Child; Child Behavior; Child, Preschool; Cognition; Epilepsy; Female; Humans; Intelli

1992
The effect of carnitine on the metabolism of valproic acid in epileptic patients.
    The Tohoku journal of experimental medicine, 1992, Volume: 167, Issue:2

    Topics: Adolescent; Adult; Carnitine; Child; Epilepsy; Female; Half-Life; Humans; Male; Valproic Acid

1992
Cognitive effects of antiepileptic drug discontinuation.
    Epilepsia, 1992, Volume: 33 Suppl 6

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Cognition; Cognition Disorders; Epilepsy; Humans;

1992
Neural tube defects in association with epilepsy and its treatment.
    Pharmaceutisch weekblad. Scientific edition, 1992, Jun-19, Volume: 14, Issue:3A

    Topics: Epilepsy; Female; Humans; Neural Tube Defects; Pregnancy; Pregnancy Complications; Valproic Acid

1992
Fatal pancytopenia during high-dose valproate monotherapy.
    European journal of pediatrics, 1992, Volume: 151, Issue:8

    Topics: Child, Preschool; Epilepsy; Female; Humans; Pancytopenia; Valproic Acid

1992
Changes in cognitive functions in epileptics on sodium valproate monotherapy.
    Indian journal of physiology and pharmacology, 1992, Volume: 36, Issue:2

    Topics: Adolescent; Adult; Cognition; Epilepsy; Female; Humans; Male; Valproic Acid

1992
Interactions between clobazam and standard antiepileptic drugs in patients with epilepsy.
    Therapeutic drug monitoring, 1992, Volume: 14, Issue:4

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbama

1992
[Disseminated intravascular coagulation in an epileptic infant under the treatment with sodium valproate].
    No to hattatsu = Brain and development, 1992, Volume: 24, Issue:3

    Topics: Disseminated Intravascular Coagulation; Drug Eruptions; Epilepsy; Female; Humans; Infant; Valproic A

1992
Pharmacokinetics, anticonvulsant efficacy, and adverse effects of trans-2-en-valproate after acute and chronic administration in amygdala-kindled rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 1992, Volume: 345, Issue:2

    Topics: Amygdala; Animals; Epilepsy; Female; Injections, Intraperitoneal; Kindling, Neurologic; Muscle Relax

1992
Spectrum of neural-tube defects in 34 infants prenatally exposed to antiepileptic drugs.
    Neurology, 1992, Volume: 42, Issue:4 Suppl 5

    Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Infant; Infant,

1992
The risk of spina bifida aperta after first-trimester exposure to valproate in a prenatal cohort.
    Neurology, 1992, Volume: 42, Issue:4 Suppl 5

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Fetal Diseases; Humans; Infant; Infant, Newborn; Male; Pre

1992
Antiepileptics and the development of congenital anomalies.
    Neurology, 1992, Volume: 42, Issue:4 Suppl 5

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Apgar Score; Birth Weight; Carbamazepine; Epilepsy; Fe

1992
Epilepsy, antiepileptic drugs, and malformations in children of women with epilepsy: a French prospective cohort study.
    Neurology, 1992, Volume: 42, Issue:4 Suppl 5

    Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Cohort Studies; Epilepsy; Female; Humans; Odds

1992
Antiepileptic drugs and teratogenesis in two consecutive cohorts: changes in prescription policy paralleled by changes in pattern of malformations.
    Neurology, 1992, Volume: 42, Issue:4 Suppl 5

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Cohort Studies; Drug Prescriptions; Epi

1992
Clinical utility of unbound antiepileptic drug blood levels in the management of epilepsy.
    Neurology, 1992, Volume: 42, Issue:5

    Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Humans; Phenytoin; Valproic Aci

1992
Anticonvulsant-induced chronic pancreatitis. A case report.
    The Italian journal of gastroenterology, 1992, Volume: 24, Issue:5

    Topics: Adult; Anticonvulsants; Carbamazepine; Chronic Disease; Cytochrome P-450 Enzyme System; Epilepsy; Fr

1992
Flunarizine--effective add-on therapy in reading epilepsy.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1992, Volume: 82, Issue:1

    Topics: Adult; Drug Therapy, Combination; Electroencephalography; Epilepsy; Flunarizine; Humans; Male; Readi

1992
Valproic-acid-induced pancytopenia and Coombs test positivity.
    Lancet (London, England), 1991, May-18, Volume: 337, Issue:8751

    Topics: Adolescent; Coombs Test; Epilepsy; Female; Humans; Pancytopenia; Valproic Acid

1991
Influence of antiepileptic drugs on sleep patterns.
    Epilepsy research. Supplement, 1991, Volume: 2

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Brain; Carbamazepine; Chil

1991
Antiepileptic activity of 1,3-dihexadecanoylamino-2-valproyl-propan-2-ol, a prodrug of valproic acid endowed with a tropism for the central nervous system.
    The Journal of pharmacy and pharmacology, 1991, Volume: 43, Issue:11

    Topics: Administration, Oral; Animals; Anticonvulsants; Central Nervous System; Drug Design; Electroshock; E

1991
Anticonvulsant activity of di-n-propylacetate and brain monoamine metabolism in the rat.
    Clinical and experimental pharmacology & physiology, 1990, Volume: 17, Issue:1

    Topics: Animals; Biogenic Monoamines; Brain; Catecholamines; Epilepsy; Female; gamma-Aminobutyric Acid; Homo

1990
Guanidino compound levels in the serum of healthy adults and epileptic patients.
    Epilepsy research, 1991, Volume: 8, Issue:2

    Topics: Adult; Arginine; Creatinine; Epilepsy; Female; Glycine; Guanidines; Homoarginine; Humans; Male; Phen

1991
Pattern- and age-dependency of the antiepileptic effects induced by valproic acid in the rat hippocampus.
    Canadian journal of physiology and pharmacology, 1991, Volume: 69, Issue:9

    Topics: 4-Aminopyridine; Age Factors; Animals; Epilepsy; Hippocampus; Rats; Rats, Inbred Strains; Valproic A

1991
Influence of concurrent administration of sodium valproate on the plasma concentrations of carbamazepine and its epoxide and diol metabolites.
    The Japanese journal of psychiatry and neurology, 1991, Volume: 45, Issue:2

    Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Fema

1991
Valproate-induced lethal hyperammonaemic coma in a carrier of ornithine carbamoyltransferase deficiency.
    Journal of inherited metabolic disease, 1991, Volume: 14, Issue:5

    Topics: Ammonia; Child, Preschool; Coma; Epilepsy; Female; Heterozygote; Humans; Ornithine Carbamoyltransfer

1991
[Evaluation of the effectiveness of monotherapy in the treatment of epilepsy].
    Minerva medica, 1991, Volume: 82, Issue:12

    Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Drug Evaluation; Epilepsy; Humans; Middle Aged; Pheno

1991
Single dose and steady state pharmacokinetics of valproic acid in adult epileptic patients.
    International journal of clinical pharmacology research, 1991, Volume: 11, Issue:3

    Topics: Administration, Oral; Adult; Anticonvulsants; Epilepsy; Female; Humans; Male; Middle Aged; Valproic

1991
Intrathecal antiepileptic drugs in experimental epilepsy.
    Stereotactic and functional neurosurgery, 1991, Volume: 57, Issue:3

    Topics: Animals; Anticonvulsants; Catheters, Indwelling; Disease Models, Animal; Dose-Response Relationship,

1991
[The problems of valproate therapy in severely handicapped children--valproate induced hyperammonemia and hypocarnitinemia].
    No to hattatsu = Brain and development, 1991, Volume: 23, Issue:1

    Topics: Adolescent; Adult; Ammonia; Carnitine; Child; Child, Preschool; Disabled Persons; Enteral Nutrition;

1991
Common epileptic syndromes in children.
    Pediatric annals, 1991, Volume: 20, Issue:1

    Topics: Adolescent; Adrenocorticotropic Hormone; Carbamazepine; Child; Child, Preschool; Electroencephalogra

1991
Sodium valproate in pregnancy.
    BMJ (Clinical research ed.), 1991, Jul-06, Volume: 303, Issue:6793

    Topics: Epilepsy; Female; Fetal Diseases; Humans; Neural Tube Defects; Pregnancy; Pregnancy Complications; V

1991
[Appropriate dosage for maintaining effective serum level at night after taking one dose of magnesium valproate with separate measurements of serum Mg++ concentration].
    Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry, 1991, Volume: 24, Issue:1

    Topics: Anticonvulsants; Drug Administration Schedule; Epilepsy; Humans; Magnesium; Valproic Acid

1991
Plasma uric acid in patients receiving anticonvulsant monotherapy.
    Epilepsy research, 1991, Volume: 8, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Phenobarbital; Phenytoin; Prosp

1991
The effect of valproic acid on plasma carnitine levels.
    American journal of diseases of children (1960), 1991, Volume: 145, Issue:9

    Topics: Adolescent; Anticonvulsants; Carnitine; Child; Child, Preschool; Dose-Response Relationship, Drug; D

1991
[Effects of antiepileptic drugs on delivery and early childhood--comparison among mono-therapies of valproic acid, phenytoin, carbamazepine and phenobarbital].
    Rinsho shinkeigaku = Clinical neurology, 1991, Volume: 31, Issue:3

    Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Birth Weight; Carbamazepine; Embryonic and Feta

1991
[Sialadenosis caused by long-term valproate medication].
    Laryngo- rhino- otologie, 1991, Volume: 70, Issue:7

    Topics: Adult; Dose-Response Relationship, Drug; Epilepsy; Humans; Male; Parotid Diseases; Parotid Gland; Sa

1991
Sodium valproate-induced menstrual disturbance in young women.
    Hormone research, 1991, Volume: 35, Issue:2

    Topics: Adolescent; Amenorrhea; Epilepsy; Female; Gonadotropin-Releasing Hormone; Humans; Luteinizing Hormon

1991
Antiepileptogenic effects of conventional anticonvulsants in the kindling model of epilespy.
    Annals of neurology, 1991, Volume: 29, Issue:4

    Topics: Action Potentials; Analysis of Variance; Animals; Anticonvulsants; Carbamazepine; Epilepsy; Kindling

1991
Ammonia and carnitine concentrations in children treated with sodium valproate compared with other anticonvulsant drugs.
    Developmental medicine and child neurology, 1991, Volume: 33, Issue:9

    Topics: Adolescent; Ammonia; Anticonvulsants; Carnitine; Child; Child, Preschool; Epilepsy; Erythrocytes; Fe

1991
Pharmacokinetics of total and free valproic acid during monotherapy in infants.
    Journal of neurology, 1991, Volume: 238, Issue:6

    Topics: Blood Proteins; Epilepsy; Female; Half-Life; Humans; Infant; Male; Valproic Acid

1991
Use of antiepileptic drugs in childhood epilepsy.
    Archives of disease in childhood, 1991, Volume: 66, Issue:10

    Topics: Adult; Aminocaproates; Anticonvulsants; Chemical and Drug Induced Liver Injury; Child; Child, Presch

1991
Epileptic patients refractory to drug therapy.
    Italian journal of neurological sciences, 1991, Volume: 12, Issue:5

    Topics: Adult; Carbamazepine; Epilepsy; Female; Humans; Immunoglobulin G; Immunoglobulins; Male; Middle Aged

1991
Late low magnesium-induced epileptiform activity in rat entorhinal cortex slices becomes insensitive to the anticonvulsant valproic acid.
    Neuroscience letters, 1990, Oct-30, Volume: 119, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Electrophysiology; Epilepsy; Hippocampus; In

1990
Seizures: introduction and commentary.
    Pediatric annals, 1991, Volume: 20, Issue:1

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Humans; Phenobarbital; Phenytoin; Valpr

1991
Muscle carnitine deficiency in patients using valproic acid.
    The Journal of pediatrics, 1991, Volume: 118, Issue:4 Pt 1

    Topics: Carnitine; Child, Preschool; Epilepsy; Humans; Infant; Muscles; Valproic Acid

1991
Effects of carbamazepine and valproate on immunological assessment in young epileptic patients.
    Italian journal of neurological sciences, 1991, Volume: 12, Issue:1

    Topics: Adolescent; Carbamazepine; Epilepsy; Female; Humans; Immunoglobulins; Lymphocyte Subsets; Male; Refe

1991
Nomogram for the prediction of unbound phenytoin concentrations in patients on a combined treatment of phenytoin and valproic acid.
    European neurology, 1991, Volume: 31, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Chromatography, Gas; Chromatogr

1991
PIVKA-II (protein induced by vitamin K absence-II) status in newborns exposed to anticonvulsant drugs in utero.
    Nihon Sanka Fujinka Gakkai zasshi, 1991, Volume: 43, Issue:3

    Topics: Adult; Anticonvulsants; Biomarkers; Diazepam; Epilepsy; Factor VII; Factor X; Female; Humans; Infant

1991
Serum lipids, lipoproteins and apolipoproteins A and B in epileptic patients treated with valproic acid, carbamazepine or phenobarbital.
    Acta neurologica Scandinavica, 1991, Volume: 83, Issue:4

    Topics: Adolescent; Adult; Analysis of Variance; Apolipoproteins A; Apolipoproteins B; Carbamazepine; Child;

1991
Total and free valproic acid: plasma level/dose ratio in monotherapy.
    Methods and findings in experimental and clinical pharmacology, 1991, Volume: 13, Issue:3

    Topics: Adolescent; Adult; Aged; Aging; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsy;

1991
Effects of acute valproic acid administration on carnitine plasma concentrations in epileptic patients.
    Epilepsy research, 1991, Volume: 8, Issue:2

    Topics: Adult; Ammonia; Carnitine; Epilepsy; Humans; Phenobarbital; Phenytoin; Valproic Acid

1991
[Pellagra in anticonvulsive therapy].
    Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde, 1990, Volume: 138, Issue:12

    Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Ethosuximide; Female; Humans; Intellect

1990
Hyperaminoacidemia in epileptic children treated with valproic acid.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 1990, Volume: 6, Issue:8

    Topics: Adolescent; Amino Acids; Ammonia; Child; Child, Preschool; Epilepsy; Humans; Infant; Valproic Acid

1990
The effects of phenytoin and carbamazepine on serum concentrations of mono-unsaturated metabolites of valproic acid.
    British journal of clinical pharmacology, 1990, Volume: 29, Issue:1

    Topics: Adult; Aged; Biotransformation; Carbamazepine; Drug Interactions; Epilepsy; Female; Humans; Male; Mi

1990
The effect of valproic acid on SCE and chromosome aberrations in epileptic children.
    Mutation research, 1990, Volume: 243, Issue:1

    Topics: Adolescent; Child; Child, Preschool; Chromosome Aberrations; Dose-Response Relationship, Drug; Epile

1990
L-carnitine replacement therapy in chronic valproate treatment.
    Neuropediatrics, 1990, Volume: 21, Issue:1

    Topics: Adolescent; Carnitine; Child; Chronic Disease; Epilepsy; Female; Humans; Ketone Bodies; Lipid Metabo

1990
Fluctuations of unbound and total phenytoin concentrations during the day in epileptic patients on valproic acid comedication.
    Therapeutic drug monitoring, 1990, Volume: 12, Issue:2

    Topics: Adolescent; Adult; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Middle Aged; Phen

1990
Anticonvulsant therapy increases fentanyl requirements during anaesthesia for craniotomy.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1990, Volume: 37, Issue:3

    Topics: Adolescent; Adult; Anesthesia, Intravenous; Anticonvulsants; Carbamazepine; Craniotomy; Drug Interac

1990
Pilot study to determine the interaction of oxiracetam with antiepileptic drugs.
    Clinical pharmacokinetics, 1990, Volume: 18, Issue:4

    Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbamazepine; Clob

1990
Eyelid twitching seizures and generalized tonic-clonic convulsions: a syndrome of idiopathic generalized epilepsy.
    Annals of neurology, 1990, Volume: 27, Issue:3

    Topics: Acetazolamide; Adult; Epilepsy; Eyelid Diseases; Female; Humans; Phenytoin; Spasm; Valproic Acid

1990
Cognitive effects of valproate.
    Epilepsy research, 1990, Volume: 5, Issue:2

    Topics: Adult; Anticonvulsants; Cognition; Epilepsy; Female; Humans; Male; Neuropsychological Tests; Psychom

1990
[Incidence of pathologic ammonia concentrations in the plasma in children with seizure disorders treated with Convulsofin/Convulex and other anticonvulsants in comparison with children with brain damage and healthy children].
    Kinderarztliche Praxis, 1990, Volume: 58, Issue:1

    Topics: Adolescent; Ammonia; Anticonvulsants; Brain Damage, Chronic; Chemical and Drug Induced Liver Injury;

1990
Valproic acid-induced carbamazepine-10,11-epoxide toxicity in children and adolescents.
    European neurology, 1990, Volume: 30, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Interactions; Epile

1990
Carbamazepine metabolism in humans: effect of concurrent anticonvulsant therapy.
    Therapeutic drug monitoring, 1990, Volume: 12, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Carbamazepine; Chromatography, High Pressure Liquid; Drug I

1990
Inhibition of epoxide hydrolase by valproic acid in epileptic patients receiving carbamazepine.
    British journal of clinical pharmacology, 1990, Volume: 29, Issue:6

    Topics: Adolescent; Blood Proteins; Carbamazepine; Child; Epilepsy; Epoxide Hydrolases; Female; Humans; Male

1990
The effect of valproic acid on sister chromatid exchange aberration frequency in epileptic children.
    Chinese medical journal, 1990, Volume: 103, Issue:5

    Topics: Adolescent; Child; Child, Preschool; Epilepsy; Humans; Infant; Sister Chromatid Exchange; Valproic A

1990
Valproate-induced hepatoxicity: protective effect of L-carnitine supplementation.
    The Japanese journal of psychiatry and neurology, 1990, Volume: 44, Issue:2

    Topics: Anticonvulsants; Carnitine; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Dose-Re

1990
Treatment of epilepsy in people with multiple handicap.
    Archives of disease in childhood, 1990, Volume: 65, Issue:4

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Disabled Persons; Epilepsy; Hum

1990
Antiepileptic medications.
    Compendium (Newtown, Pa.). Supplement, 1990, Mar-06, Issue:14

    Topics: Anticonvulsants; Barbiturates; Carbamazepine; Dental Care for Disabled; Epilepsy; Humans; Hydantoins

1990
Neocerebellar hypoplasia in a neonate following intra-uterine exposure to anticonvulsants.
    Developmental medicine and child neurology, 1990, Volume: 32, Issue:8

    Topics: Abnormalities, Drug-Induced; Cerebellum; Drug Therapy, Combination; Epilepsy; Female; Humans; Nerve

1990
[Blood level profile of valproate administration under therapeutic conditions in children].
    Padiatrie und Grenzgebiete, 1990, Volume: 29, Issue:4

    Topics: Adolescent; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ep

1990
Valproic acid-associated encephalopathy.
    The Western journal of medicine, 1990, Volume: 153, Issue:2

    Topics: Epilepsy; Female; Humans; Middle Aged; Valproic Acid

1990
Cognitive effects of long-term treatment with phenobarbital and valproic acid in school children.
    Acta neurologica Scandinavica, 1990, Volume: 81, Issue:6

    Topics: Child; Epilepsy; Female; Follow-Up Studies; Humans; Intelligence; Learning Disabilities; Male; Pheno

1990
[Inequality of bioavailability in commercial tablets of valproic acid].
    No to hattatsu = Brain and development, 1990, Volume: 22, Issue:5

    Topics: Adolescent; Adult; Biological Availability; Child; Circadian Rhythm; Epilepsy; Female; Humans; Male;

1990
Pattern-reversal visual evoked potentials recorded in children with generalized epilepsy.
    Clinical EEG (electroencephalography), 1990, Volume: 21, Issue:4

    Topics: Adolescent; Analysis of Variance; Anticonvulsants; Carbamazepine; Child; Epilepsy; Evoked Potentials

1990
Rapid anti-epileptic drug assay.
    Developmental medicine and child neurology, 1990, Volume: 32, Issue:9

    Topics: Anticonvulsants; Carbamazepine; Child; Dose-Response Relationship, Drug; Epilepsy; Ethosuximide; Hum

1990
[Computerized analysis of EEG background activity in mono-therapeutic patients with epilepsy--relationships between antiepileptic drugs and types of seizures].
    No to shinkei = Brain and nerve, 1990, Volume: 42, Issue:9

    Topics: Adult; Anticonvulsants; Brain Mapping; Carbamazepine; Electroencephalography; Epilepsy; Female; Huma

1990
Effects of age and antiepileptic drugs on plasma levels and kinetics of clobazam and N-desmethylclobazam.
    Pharmacology & toxicology, 1990, Volume: 67, Issue:2

    Topics: Adolescent; Adult; Age Factors; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepin

1990
Postmortem serum protein binding and brain concentrations of antiepileptic drugs in autoptic specimens from 45 epileptic patients.
    Therapeutic drug monitoring, 1990, Volume: 12, Issue:6

    Topics: Anticonvulsants; Blood Proteins; Brain; Carbamazepine; Epilepsy; Female; Humans; Male; Phenobarbital

1990
[A clinicopharmacological study of serum sodium valproate free level in children with epilepsy].
    Nihon Ika Daigaku zasshi, 1990, Volume: 57, Issue:6

    Topics: Adolescent; Adult; Age Factors; Blood Proteins; Child; Child, Preschool; Circadian Rhythm; Epilepsy;

1990
Comparative experimental study of antiepileptics--regional specificity of antiepileptic action of carbamazepine, phenobarbital and valproate sodium.
    Brain & development, 1990, Volume: 12, Issue:5

    Topics: Animals; Anticonvulsants; Carbamazepine; Epilepsy; Hippocampus; Male; Motor Cortex; Phenobarbital; R

1990
Cognitive function in adult epileptic patients established on anticonvulsant monotherapy.
    Epilepsy research, 1990, Volume: 7, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Cognition; Epilepsy; Female; Humans; Intelligence

1990
[Case of epilepsy in an infant with fatal outcome during the 1st year of unknown etiology].
    Revue d'electroencephalographie et de neurophysiologie clinique, 1985, Volume: 14, Issue:4

    Topics: Developmental Disabilities; Drug Resistance; Electroencephalography; Epilepsy; Humans; Infant; Infan

1985
Valproic acid and phenytoin effects on serum proteins and immunoglobulins of epileptic patients.
    General pharmacology, 1985, Volume: 16, Issue:4

    Topics: Adolescent; Adult; Aged; Alpha-Globulins; Beta-Globulins; Blood Proteins; Child; Child, Preschool; E

1985
EEG characteristics of epileptic pattern sensitivity and their relation to the nature of pattern stimulation and the effects of sodium valproate.
    Electroencephalography and clinical neurophysiology, 1986, Volume: 63, Issue:6

    Topics: Adolescent; Adult; Child; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Female

1986
Side-effects of sodium valproate, mainly related to its hepatic and pancreatic toxicity.
    International journal of clinical pharmacology research, 1986, Volume: 6, Issue:3

    Topics: Adolescent; Adult; Aged; Amylases; Body Weight; Chemical and Drug Induced Liver Injury; Child; Child

1986
The action of valproate on spontaneous epileptiform activity in the absence of synaptic transmission and on evoked changes in [Ca2+]o and [K+]o in the hippocampal slice.
    Brain research, 1986, Oct-29, Volume: 386, Issue:1-2

    Topics: Animals; Calcium; Cell Membrane Permeability; Electric Stimulation; Epilepsy; Hippocampus; In Vitro

1986
The effects of carbamazepine and sodium valproate on SEPs and BAEPs.
    Electroencephalography and clinical neurophysiology, 1987, Volume: 68, Issue:6

    Topics: Adult; Aged; Brain Stem; Carbamazepine; Epilepsy; Evoked Potentials, Auditory; Evoked Potentials, So

1987
Drugs for epilepsy.
    The Medical letter on drugs and therapeutics, 1989, Jan-13, Volume: 31, Issue:783

    Topics: Adult; Anticonvulsants; Carbamazepine; Child; Drug Interactions; Epilepsy; Humans; Phenytoin; Valpro

1989
Pharmacokinetics of valproate in adults after a single loading dose.
    Archives of neurology, 1989, Volume: 46, Issue:1

    Topics: Administration, Oral; Administration, Rectal; Adult; Epilepsy; Humans; Valproic Acid

1989
[The first case of a child born with fetal valproic acid syndrome in Hungary].
    Orvosi hetilap, 1989, Jan-29, Volume: 130, Issue:5

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Maternal-Fe

1989
Serum aspirin-esterase activity in epileptic patients receiving treatment with phenobarbital, phenytoin, carbamazepine and valproic acid.
    International journal of clinical pharmacology research, 1989, Volume: 9, Issue:1

    Topics: Adult; Anticonvulsants; Aspirin; Carbamazepine; Epilepsy; Esterases; Female; Humans; Male; Phenobarb

1989
Urinary excretion of valproate and some metabolites in chronically treated patients.
    Therapeutic drug monitoring, 1989, Volume: 11, Issue:2

    Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Epilepsy; Female; Humans; Hydroxylation; Male; Mid

1989
Derivation and evaluation of an equation for prediction of free phenytoin concentration in patients co-medicated with valproic acid.
    Therapeutic drug monitoring, 1989, Volume: 11, Issue:2

    Topics: Adult; Aged; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Mathematics; Middle Aged; Ph

1989
The prevalence of adverse reactions to anticonvulsants in children with epilepsy.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1989, Jun-03, Volume: 75, Issue:11

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Drug Therapy, Combi

1989
Valproic acid disposition and protein binding in pregnancy.
    Therapeutic drug monitoring, 1989, Volume: 11, Issue:3

    Topics: Adult; Epilepsy; Female; Fetal Blood; Gestational Age; Humans; Pregnancy; Protein Binding; Valproic

1989
[Medical treatment of epilepsy].
    Nordisk medicin, 1989, Volume: 104, Issue:5

    Topics: Aminocaproates; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Oxcarbazepine; Valproic Acid; Viga

1989
Protoporphyrinaemia and decreased activities of 5-aminolevulinic acid dehydrase and uroporphyrinogen I synthetase in erythrocytes of a Vitamin B6-deficient epileptic boy given valproic acid and carbamazepine.
    Clinical biochemistry, 1989, Volume: 22, Issue:3

    Topics: Ammonia-Lyases; Carbamazepine; Chromatography, Ion Exchange; Epilepsy; Erythrocytes; Folic Acid; Hum

1989
Effect of phenytoin, carbamazepine, and valproic acid on caffeine metabolism.
    European journal of clinical pharmacology, 1989, Volume: 36, Issue:4

    Topics: Adolescent; Adult; Aged; Antipyrine; Caffeine; Carbamazepine; Cytochrome P-450 Enzyme System; Enzyme

1989
[Reye syndrome treated with valproic acid in association with varicella infection].
    Der Nervenarzt, 1989, Volume: 60, Issue:5

    Topics: Adult; Aspirin; Carbamazepine; Chickenpox; Drug Therapy, Combination; Epilepsy; Humans; Male; Reye S

1989
Thyroid hormone concentrations in epileptic patients.
    European journal of clinical pharmacology, 1989, Volume: 36, Issue:3

    Topics: Anticonvulsants; Carbamazepine; Drug Combinations; Epilepsy; Humans; Phenytoin; Thyrotropin; Thyroxi

1989
[Transient Parkinson syndrome and tremor caused by the use of sodium valproate].
    Nederlands tijdschrift voor geneeskunde, 1989, Jun-17, Volume: 133, Issue:24

    Topics: Aged; Epilepsy; Female; Humans; Male; Middle Aged; Parkinson Disease, Secondary; Valproic Acid

1989
[Advantages of a single daily dose of sodium valproate in the child].
    Archives francaises de pediatrie, 1989, Volume: 46, Issue:4

    Topics: Adolescent; Child; Child, Preschool; Drug Administration Schedule; Epilepsies, Myoclonic; Epilepsy;

1989
Valproate for epilepsy in renal transplant recipients receiving cyclosporine.
    Transplantation, 1989, Volume: 48, Issue:3

    Topics: Adult; Chemical and Drug Induced Liver Injury; Cyclosporins; Epilepsy; Female; Humans; Kidney Transp

1989
Valproate prevents the recurrence of absence status.
    Neurology, 1989, Volume: 39, Issue:10

    Topics: Adolescent; Adult; Aged; Epilepsy; Epilepsy, Absence; Female; Follow-Up Studies; Humans; Male; Middl

1989
The effect of concurrent administration of sodium valproate on serum levels of primidone and its metabolite phenobarbital.
    Journal of clinical pharmacy and therapeutics, 1989, Volume: 14, Issue:5

    Topics: Adolescent; Adult; Child; Child, Preschool; Drug Interactions; Drug Therapy, Combination; Epilepsy;

1989
Improvement in cognitive functioning and mood state after conversion to valproate monotherapy.
    Neurology, 1989, Volume: 39, Issue:12

    Topics: Affect; Anticonvulsants; Cognition; Epilepsy; Humans; Neuropsychological Tests; Valproic Acid

1989
Epilepsy in women of childbearing age.
    BMJ (Clinical research ed.), 1989, Nov-04, Volume: 299, Issue:6708

    Topics: Abnormalities, Drug-Induced; Adult; Carbamazepine; Epilepsy; Female; Humans; Pregnancy; Pregnancy Co

1989
[Valproate induced fetopathy and somatic and psychomotor development].
    Archives francaises de pediatrie, 1989, Volume: 46, Issue:8

    Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Fetal Diseases; Humans; Maternal-Fetal Exchange; Preg

1989
Valproate and spina bifida.
    The Practitioner, 1989, Sep-08, Volume: 233, Issue:1474

    Topics: Adult; Epilepsy; Female; Humans; Maternal-Fetal Exchange; Pregnancy; Pregnancy Complications; Spina

1989
Serum free levels and evaluation anticonvulsant drug interactions.
    Wisconsin medical journal, 1989, Volume: 88, Issue:12

    Topics: Adult; Anticonvulsants; Drug Interactions; Epilepsy; Humans; Male; Phenobarbital; Phenytoin; Valproi

1989
[Factors influencing the effectiveness of preventive treatment of febrile convulsions].
    Anales espanoles de pediatria, 1989, Volume: 31, Issue:2

    Topics: Anticonvulsants; Child; Drug Evaluation; Epilepsy; Female; Fever; Humans; Male; Phenobarbital; Primi

1989
Probable pseudocholinesterase induction by valproic acid, carbamazepine and phenytoin leading to increased serum aspirin-esterase activity in epileptics.
    International journal of clinical pharmacology research, 1989, Volume: 9, Issue:5

    Topics: Adolescent; Adult; Analysis of Variance; Carbamazepine; Carboxylic Ester Hydrolases; Cholinesterases

1989
Sustained attention during the interictal period of mentally normal children with epilepsy or febrile convulsions, and the influence of anticonvulsants and seizures on attention.
    The Japanese journal of psychiatry and neurology, 1989, Volume: 43, Issue:3

    Topics: Anticonvulsants; Attention; Carbamazepine; Child; Drug Therapy, Combination; Epilepsies, Partial; Ep

1989
Cardiazol-induced seizures and the concentration of lipid peroxides in the brain of rats under the influence of valproic acid and vitamin E.
    Neuropatologia polska, 1989, Volume: 27, Issue:2

    Topics: Animals; Anticonvulsants; Antioxidants; Cerebral Cortex; Convulsants; Drug Therapy, Combination; Epi

1989
Effects of anticonvulsants on spontaneous epileptiform activity which develops in the absence of chemical synaptic transmission in hippocampal slices.
    Brain research, 1985, Jan-28, Volume: 325, Issue:1-2

    Topics: Animals; Anticonvulsants; Benzodiazepines; Carbamazepine; Cell Membrane Permeability; Epilepsy; Hipp

1985
Dynamic aspects in transient hyperphosphatasaemia of infancy.
    Acta paediatrica Scandinavica, 1988, Volume: 77, Issue:3

    Topics: Adenoviridae Infections; Alkaline Phosphatase; Epilepsy; Half-Life; Humans; Infant; Male; Valproic A

1988
Neuroendocrine effects of chronic administration of sodium valproate in epileptic patients.
    Acta endocrinologica, 1988, Volume: 118, Issue:3

    Topics: Adolescent; Adrenocorticotropic Hormone; Child; Epilepsy; Female; Growth Hormone; Growth Hormone-Rel

1988
Paradoxical enhancement of seizures in the gerbil after chronic treatment with sodium valproate.
    Neuropharmacology, 1988, Volume: 27, Issue:6

    Topics: Animals; Epilepsy; Gerbillinae; Receptors, GABA-A; Valproic Acid

1988
Valpromide/carbamazepine and risk of teratogenicity.
    Lancet (London, England), 1985, Feb-16, Volume: 1, Issue:8425

    Topics: Abnormalities, Drug-Induced; Animals; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Hu

1985
In-utero exposure to valproate and neural tube defects.
    Lancet (London, England), 1986, Jun-14, Volume: 1, Issue:8494

    Topics: Anticonvulsants; Epilepsy; Female; Fetus; Humans; Infant, Newborn; Maternal-Fetal Exchange; Neural T

1986
Fatal liver failure in children on valproate.
    Lancet (London, England), 1986, Aug-30, Volume: 2, Issue:8505

    Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Epilepsy; German

1986
Isoniazid-induced valproic-acid toxicity, or vice versa.
    Lancet (London, England), 1987, Jul-18, Volume: 2, Issue:8551

    Topics: Adolescent; Drug Interactions; Epilepsy; Female; Humans; Isoniazid; Tuberculosis; Valproic Acid

1987
Sodium valproate, pregnancy, and infantile fatal liver failure.
    Lancet (London, England), 1987, Dec-26, Volume: 2, Issue:8574

    Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Epilepsy; Female; Humans; Infant; Infant, New

1987
Gastritis with valproate therapy.
    Archives of neurology, 1988, Volume: 45, Issue:8

    Topics: Adolescent; Antacids; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy;

1988
Valproate, spina bifida, and birth defect registries.
    Lancet (London, England), 1988, Dec-17, Volume: 2, Issue:8625

    Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complications; Registrie

1988
Influence of valproate and carbamazepine on symmetrical cortical penicillin foci in the rat.
    Physiologia Bohemoslovaca, 1985, Volume: 34, Issue:6

    Topics: Animals; Carbamazepine; Dose-Response Relationship, Drug; Electrocardiography; Epilepsy; Male; Penic

1985
Valproate-associated hyperammonemia and DL-carnitine supplement.
    The Kobe journal of medical sciences, 1987, Volume: 33, Issue:3

    Topics: Adolescent; Adult; Ammonia; Carbamazepine; Carnitine; Child; Child, Preschool; Disabled Persons; Dru

1987
[Treatment of epilepsy. Superiority of a single daily dose of sodium valproate over fractionated doses].
    Presse medicale (Paris, France : 1983), 1988, Sep-10, Volume: 17, Issue:30

    Topics: Adolescent; Adult; Child; Drug Administration Schedule; Epilepsy; Humans; Valproic Acid

1988
[Sudden death in epileptics treated with valproic acid].
    Acta medicinae legalis et socialis, 1985, Volume: 35, Issue:1

    Topics: Adult; Autopsy; Death, Sudden; Drug Overdose; Epilepsy; Female; Humans; Male; Valproic Acid

1985
Prenatal detection of a neural tube defect after fetal exposure to valproic acid.
    Obstetrics and gynecology, 1986, Volume: 67, Issue:3 Suppl

    Topics: Abortion, Therapeutic; Adolescent; Epilepsy; Female; Fetal Diseases; Humans; Hydrocephalus; Meningom

1986
Valproic acid in the treatment of epilepsy during the pediatric age.
    Clinical EEG (electroencephalography), 1986, Volume: 17, Issue:1

    Topics: Adolescent; Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Follow-Up Studies; Hu

1986
Carbamazepine, phenytoin and sodium valproate monotherapy.
    Journal of neurology, neurosurgery, and psychiatry, 1986, Volume: 49, Issue:3

    Topics: Carbamazepine; Epilepsy; Humans; Phenytoin; Valproic Acid

1986
Sodium valproate monotherapy in childhood epilepsy.
    Brain & development, 1986, Volume: 8, Issue:1

    Topics: Adolescent; Adult; Body Weight; Child; Child, Preschool; Electroencephalography; Epilepsies, Myoclon

1986
[Visual evoked potentials in photosensitive epilepsy--effect of valproic acid therapy].
    No to hattatsu = Brain and development, 1986, Volume: 18, Issue:3

    Topics: Adolescent; Epilepsy; Female; Humans; Light; Valproic Acid

1986
Fetal growth, major malformations, and minor anomalies in infants born to women receiving valproic acid.
    The Journal of pediatrics, 1986, Volume: 108, Issue:6

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Epilepsy; Female; Fetus; Growth; Humans; Infant, New

1986
Sodium valproate in epilepsy treatment.
    The Practitioner, 1986, Volume: 230, Issue:1413

    Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy; Humans; Valproic Acid

1986
Development of tolerance to the anticonvulsant effect of GABAmimetic drugs in genetically epilepsy-prone gerbils.
    Pharmacology, biochemistry, and behavior, 1986, Volume: 24, Issue:4

    Topics: Acetates; Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Diazepam; D

1986
[Possible uses of Convulsofin liquid in the treatment of pediatric epilepsies].
    Psychiatrie, Neurologie, und medizinische Psychologie, 1986, Volume: 38, Issue:3

    Topics: Administration, Oral; Adolescent; Child; Child, Preschool; Epilepsies, Myoclonic; Epilepsies, Partia

1986
Renal handling of carnitine in children with carnitine deficiency and hyperammonemia associated with valproate therapy.
    The Journal of pediatrics, 1986, Volume: 109, Issue:1

    Topics: Ammonia; Carnitine; Epilepsy; Humans; Infant; Intellectual Disability; Kidney; Metabolic Clearance R

1986
Behavioral toxicity of chronic ethosuximide and sodium valproate treatment in the epileptic baboon, Papio papio.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 238, Issue:1

    Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Epilepsy; Ethosuximide; Female; Ma

1986
[Hyperammonemia in valproate therapy in children and adolescents].
    Der Nervenarzt, 1986, Volume: 57, Issue:5

    Topics: Adolescent; Ammonia; Anticonvulsants; Child; Drug Therapy, Combination; Epilepsy; Female; Humans; Ma

1986
Phenylethylmalonamide serum levels in patients treated with primidone and the effects of other antiepileptic drugs.
    Therapeutic drug monitoring, 1986, Volume: 8, Issue:2

    Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Humans; Malonates; Phenobarbita

1986
[Hyperammonemia during sodium valproate therapy: clinically relevant or accidental finding?].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1986, Jul-15, Volume: 75, Issue:29

    Topics: Adult; Aged; Ammonia; Epilepsy; Female; Humans; Male; Middle Aged; Valproic Acid

1986
[Valproic acid, curly hair and weight gain].
    Arquivos de neuro-psiquiatria, 1986, Volume: 44, Issue:1

    Topics: Adult; Body Weight; Epilepsy; Female; Hair; Humans; Valproic Acid

1986
Drugs for epilepsy.
    The Medical letter on drugs and therapeutics, 1986, Sep-26, Volume: 28, Issue:723

    Topics: Adult; Anticonvulsants; Carbamazepine; Child; Drug Interactions; Epilepsy; Humans; Phenytoin; Status

1986
A comparative study of the relative influence of different anticonvulsant drugs, UV exposure and diet on vitamin D and calcium metabolism in out-patients with epilepsy.
    The Quarterly journal of medicine, 1986, Volume: 59, Issue:230

    Topics: Adult; Calcium; Carbamazepine; Diet; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin; Ultra

1986
[Various matters concerning the improvement of therapeutic tactics in epilepsy].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1986, Volume: 86, Issue:6

    Topics: Adolescent; Adult; Anticonvulsants; Barbiturates; Benzodiazepines; Carbamazepine; Drug Therapy, Comb

1986
[Abnormal 13C-palmitate breath test in epileptic patients treated with valproic acid].
    No to hattatsu = Brain and development, 1986, Volume: 18, Issue:5

    Topics: Adolescent; Age Factors; Breath Tests; Carbon Isotopes; Child; Epilepsy; Fatty Acids; Female; Humans

1986
[Determination of N-Dipropylacetamide serum concentration and its clinical significance in epileptic children].
    Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry, 1986, Volume: 19, Issue:4

    Topics: Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Valproic Acid

1986
Memory disturbances in epileptic patients.
    Acta neurologica Scandinavica. Supplementum, 1986, Volume: 109

    Topics: Carbamazepine; Drug Therapy, Combination; Epilepsy; Humans; Memory Disorders; Phenytoin; Valproic Ac

1986
Synergistic effects of oxiracetam and piracetam in combination with antiepileptic drugs.
    Acta neurologica Scandinavica. Supplementum, 1986, Volume: 109

    Topics: Animals; Anticonvulsants; Carbamazepine; Clonazepam; Drug Synergism; Drug Therapy, Combination; Epil

1986
Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy.
    Clinical neuropharmacology, 1987, Volume: 10, Issue:1

    Topics: Adolescent; Adult; Child; Child, Preschool; Copper; Epilepsy; Erythrocytes; Female; Humans; Male; Mi

1987
Effects of coadministered antiepileptic drugs on free fractions of phenobarbital and valproic acid in epileptic children.
    The Kobe journal of medical sciences, 1986, Volume: 32, Issue:5

    Topics: Anticonvulsants; Child; Drug Therapy, Combination; Epilepsy; Humans; Phenobarbital; Serum Albumin; V

1986
[Epilepsy with continuous discharges during slow-wave sleep. Treatment with clobazam].
    Revue d'electroencephalographie et de neurophysiologie clinique, 1986, Volume: 16, Issue:4

    Topics: Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Carbamazepine; Child; Child, Preschool; Clo

1986
Forced normalization. Acute psychosis after seizure control in seven patients.
    Archives of neurology, 1987, Volume: 44, Issue:3

    Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Haloperidol; Humans; Male; Psychotic Disord

1987
Clinically significant danazol-carbamazepine interaction.
    Therapeutic drug monitoring, 1987, Volume: 9, Issue:1

    Topics: Adult; Carbamazepine; Danazol; Drug Interactions; Epilepsy; Female; Fibrocystic Breast Disease; Huma

1987
Long-term treatment with sodium valproate: monitoring of venous ammonia concentrations and adverse effects.
    Therapeutic drug monitoring, 1987, Volume: 9, Issue:1

    Topics: Adolescent; Adult; Alopecia; Ammonia; Body Weight; Child; Epilepsy; Female; Gastrointestinal Disease

1987
[Modification of psychophysical performance of the human by anticonvulsants].
    Psychiatrie, Neurologie, und medizinische Psychologie, 1987, Volume: 39, Issue:1

    Topics: Anticonvulsants; Arousal; Carbamazepine; Diazepam; Epilepsy; Ethosuximide; Humans; Mental Processes;

1987
Valproate for epilepsy in renal transplant recipients receiving cyclosporine.
    Transplantation, 1987, Volume: 43, Issue:6

    Topics: Adult; Cyclosporins; Drug Interactions; Epilepsy; Female; Humans; Kidney Transplantation; Valproic A

1987
Barbiturate-refractory epilepsy: safe schedule for therapeutic substitution.
    Arquivos de neuro-psiquiatria, 1986, Volume: 44, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Barbiturates; Carbamazepine; Drug Tolerance; Epilepsy; Female; H

1986
Valproic acid loading during intensive monitoring.
    Archives of neurology, 1987, Volume: 44, Issue:7

    Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Humans; Male; Monitoring, Physiologic; Substan

1987
Prescribing in pregnancy.
    British medical journal (Clinical research ed.), 1987, Jan-17, Volume: 294, Issue:6565

    Topics: Epilepsy; Female; Humans; Neural Tube Defects; Pregnancy; Pregnancy Complications; Valproic Acid

1987
Status epilepticus within the Lennox-Gastaut syndrome: clinical characteristics and management.
    Clinical EEG (electroencephalography), 1987, Volume: 18, Issue:2

    Topics: Child; Clonazepam; Electroencephalography; Epilepsy; Humans; Male; Status Epilepticus; Syndrome; Val

1987
Blood ammonia level during valproic acid therapy.
    The Japanese journal of psychiatry and neurology, 1986, Volume: 40, Issue:4

    Topics: Adolescent; Adult; Ammonia; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Female; Hu

1986
[Side effects of valproate in epileptic children].
    Kinderarztliche Praxis, 1987, Volume: 55, Issue:4

    Topics: Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Long-Term Care; Male; Valproi

1987
A suspected case of late-onset sodium-valproate-induced hepatic failure.
    Neuropediatrics, 1987, Volume: 18, Issue:2

    Topics: Adolescent; Drug Therapy, Combination; Epilepsy; Hepatic Encephalopathy; Humans; Liver; Male; Valpro

1987
Anticonvulsant drugs in monotherapy. Effect on the fetus.
    European journal of epidemiology, 1987, Volume: 3, Issue:2

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fe

1987
[Significance of the determination of valproate levels in the blood].
    Ceskoslovenska neurologie a neurochirurgie, 1987, Volume: 50, Issue:3

    Topics: Adult; Epilepsy; Female; Humans; Male; Valproic Acid

1987
Bioavailability of sodium valproate suppositories during repeated administration at steady state in epileptic children.
    European journal of pediatrics, 1987, Volume: 146, Issue:4

    Topics: Administration, Oral; Adolescent; Biological Availability; Child; Child, Preschool; Epilepsy; Female

1987
Determination of valproic acid and its metabolites by gas chromatography-mass spectrometry with selected ion monitoring.
    Journal of chromatography, 1987, Jul-24, Volume: 399

    Topics: Adolescent; Adult; Biotransformation; Child; Child, Preschool; Drug Stability; Epilepsy; Female; Gas

1987
[Cognitive effects of antiepileptic drugs].
    Revue neurologique, 1987, Volume: 143, Issue:5

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cognition Disorders; Epilepsy;

1987
Serum valproate concentrations in epileptic children with favourable responses.
    Brain & development, 1987, Volume: 9, Issue:3

    Topics: Adolescent; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsies, Partial; Epilepsy

1987
[Study, in mice, of the influence of intestinal parasitic disease on the antiepileptic effects of sodium valproate].
    Annales pharmaceutiques francaises, 1987, Volume: 45, Issue:1

    Topics: Animals; Anticonvulsants; Epilepsy; Male; Mice; Oxyuriasis; Pyrantel Pamoate; Valproic Acid

1987
The management of epilepsy in women of child-bearing age and the Australian experience of valproate in pregnancy.
    Clinical and experimental neurology, 1987, Volume: 23

    Topics: Abnormalities, Drug-Induced; Australia; Epilepsy; Female; Humans; Infant, Newborn; Pregnancy; Pregna

1987
Bidirectional effects of beta-carbolines in reflex epilepsy.
    Brain research bulletin, 1987, Volume: 19, Issue:3

    Topics: Animals; Anticonvulsants; Brain; Carbolines; Epilepsy; Female; gamma-Aminobutyric Acid; Male; Mice;

1987
[Valproic acid monotherapy in epilepsies in childhood and adolescence].
    Padiatrie und Padologie, 1987, Volume: 22, Issue:3

    Topics: Adolescent; Child; Child, Preschool; Electroencephalography; Epilepsies, Partial; Epilepsy; Evoked P

1987
[Effects of sodium valproate on amino acid concentrations in serum and urine].
    No to hattatsu = Brain and development, 1987, Volume: 19, Issue:6

    Topics: Adolescent; Adult; Amino Acids; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Val

1987
Divalproex/valproate monotherapy: an international perspective. Proceedings of a symposium held in conjunction with the 1986 American Epilepsy Society meeting, Seattle, Washington.
    Epilepsia, 1987, Volume: 28 Suppl 2

    Topics: Epilepsy; Humans; Valproic Acid

1987
Effect of chronic valproic acid treatment on plasma and urine carnitine levels in children: decreased urinary excretion.
    Acta paediatrica Hungarica, 1987, Volume: 28, Issue:2

    Topics: Adolescent; Carnitine; Child; Epilepsy; Humans; Male; Valproic Acid

1987
[Side effects of valproic acid therapy in adulthood].
    Der Nervenarzt, 1988, Volume: 59, Issue:1

    Topics: alpha-Amylases; Drug Therapy, Combination; Epilepsy; Female; Humans; Leukopenia; Liver Function Test

1988
Treatment of childhood epilepsy with rectal valproate: case reports and pharmacokinetic study.
    Brain & development, 1987, Volume: 9, Issue:6

    Topics: Administration, Rectal; Epilepsy; Female; Humans; Infant; Male; Valproic Acid

1987
An interaction between cytostatic and anticonvulsant drugs.
    Clinical pharmacology and therapeutics, 1988, Volume: 43, Issue:4

    Topics: Adenocarcinoma, Papillary; Adult; Altretamine; Antineoplastic Combined Chemotherapy Protocols; Carba

1988
The effective evaluation of thyroid status in patients on phenytoin, carbamazepine or sodium valproate attending an epilepsy clinic.
    Postgraduate medical journal, 1987, Volume: 63, Issue:744

    Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Male; Midd

1987
Plasma concentrations of unbound valproate and the management of epilepsy.
    Australian and New Zealand journal of medicine, 1987, Volume: 17, Issue:6

    Topics: Adolescent; Adult; Epilepsy; Female; Humans; Male; Middle Aged; Protein Binding; Valproic Acid

1987
Is valproate monotherapy a practical possibility in chronically uncontrolled epilepsy?
    Journal of clinical pharmacy and therapeutics, 1988, Volume: 13, Issue:1

    Topics: Anticonvulsants; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Valproic Acid

1988
Mono-unsaturated metabolites of valproic acid in epileptic women and their neonates.
    The Japanese journal of psychiatry and neurology, 1987, Volume: 41, Issue:3

    Topics: Adult; Epilepsy; Female; Fetus; Humans; Infant, Newborn; Maternal-Fetal Exchange; Placenta; Pregnanc

1987
Computerized EEG analysis of penicillin induced seizure threshold in developing rats.
    The Indian journal of medical research, 1987, Volume: 86

    Topics: Aging; Animals; Computers; Disease Models, Animal; Electroencephalography; Epilepsy; Penicillins; Ra

1987
[Etiologic factors in epilepsy as a predictor of response to anticonvulsive drug therapy].
    Der Nervenarzt, 1988, Volume: 59, Issue:3

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Elec

1988
Delayed bone development in epileptic children assessed by microdensitometer.
    Developmental pharmacology and therapeutics, 1988, Volume: 11, Issue:1

    Topics: Adolescent; Anticonvulsants; Bone Development; Calcifediol; Calcitriol; Child; Child, Preschool; Den

1988
Zinc concentrations in leucocytes of patients receiving antiepileptic drugs.
    Journal of clinical pathology, 1988, Volume: 41, Issue:5

    Topics: Adult; Carbamazepine; Epilepsy; Female; Humans; Male; Neutrophils; Valproic Acid; Zinc

1988
Effect of food on the serum concentration profile of enteric-coated valproic acid.
    Neurology, 1988, Volume: 38, Issue:8

    Topics: Adult; Eating; Epilepsy; Female; Humans; Male; Middle Aged; Tablets, Enteric-Coated; Valproic Acid

1988
[Effectiveness and tolerance of valproic acid monotherapy in patients with epilepsy].
    Der Nervenarzt, 1988, Volume: 59, Issue:5

    Topics: Adolescent; Adult; Anticonvulsants; Child; Drug Therapy, Combination; Epilepsy; Female; Follow-Up St

1988
Kawasaki-like syndrome caused by carbamazepine.
    The Pediatric infectious disease journal, 1988, Volume: 7, Issue:7

    Topics: Carbamazepine; Child, Preschool; Drug Hypersensitivity; Epilepsy; Humans; Male; Mucocutaneous Lymph

1988
A comparative study of the relative effects of anticonvulsant drugs and dietary folate on the red cell folate status of patients with epilepsy.
    The Quarterly journal of medicine, 1987, Volume: 65, Issue:247

    Topics: Adult; Anticonvulsants; Carbamazepine; Diet; Drug Therapy, Combination; Epilepsy; Erythrocytes; Fema

1987
Abnormal 13C-fatty acid breath tests in patients treated with valproic acid.
    Journal of child neurology, 1988, Volume: 3, Issue:4

    Topics: Adolescent; Caprylates; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsy; Fatty A

1988
Combination of valproate and ethosuximide: antiepileptic and neurotoxic interaction.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:3

    Topics: Animals; Brain; Drug Synergism; Drug Therapy, Combination; Epilepsy; Ethosuximide; Female; Mice; Mic

1988
Pharmacokinetics of free and total sodium valproate in adolescents and young adults during maintenance therapy.
    Journal of neurology, 1988, Volume: 235, Issue:8

    Topics: Adolescent; Adult; Anticonvulsants; Blood Proteins; Dose-Response Relationship, Drug; Epilepsy; Fema

1988
Hyperamino-acidaemia and hyperammonaemia in epileptic children treated with valproic acid.
    European journal of pediatrics, 1988, Volume: 148, Issue:3

    Topics: Adolescent; Amino Acids; Ammonia; Child; Child, Preschool; Epilepsy; Humans; Infant; Valproic Acid

1988
Valproate monotherapy in the treatment of epilepsy.
    The American journal of medicine, 1988, Jan-25, Volume: 84, Issue:1A

    Topics: Epilepsy; Humans; Valproic Acid

1988
Valproate monotherapy in children.
    The American journal of medicine, 1988, Jan-25, Volume: 84, Issue:1A

    Topics: Anticonvulsants; Child; Drug Therapy, Combination; Epilepsies, Myoclonic; Epilepsy; Epilepsy, Absenc

1988
Crossover from polytherapy to monotherapy in primary generalized epilepsy.
    The American journal of medicine, 1988, Jan-25, Volume: 84, Issue:1A

    Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Female; Humans; Valproic Acid

1988
Congenital abnormalities in two sibs exposed to valproic acid in utero.
    American journal of medical genetics, 1988, Volume: 31, Issue:2

    Topics: Abnormalities, Drug-Induced; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Infan

1988
Sodium valproate.
    Australian family physician, 1988, Volume: 17, Issue:10

    Topics: Australia; Drug Prescriptions; Epilepsy; Humans; Valproic Acid

1988
Predictability of unbound antiepileptic drug concentrations in children treated with valproic acid and phenytoin.
    Clinical pharmacy, 1988, Volume: 7, Issue:9

    Topics: Adolescent; Adult; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Phenytoin; Prote

1988
Variability of phenytoin, carbamazepine and valproate concentrations in a clinic population.
    Epilepsy research. Supplement, 1988, Volume: 1

    Topics: Carbamazepine; Epilepsy; Female; Humans; Male; Minnesota; Outpatient Clinics, Hospital; Patient Comp

1988
[Clinical treatment of resistant epilepsy].
    Arquivos de neuro-psiquiatria, 1988, Volume: 46, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Resistance; Electroencephalography; E

1988
Plasma concentrations of unbound valproate in the management of epilepsy.
    Australian and New Zealand journal of medicine, 1988, Volume: 18, Issue:5

    Topics: Adult; Epilepsy; Humans; Male; Valproic Acid

1988
Changes in clearance of sodium valproate with changes in dose.
    Clinical and experimental neurology, 1987, Volume: 24

    Topics: Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; M

1987
Fluorescence polarization immunoassay and enzyme immunoassay compared for free valproic acid in serum ultrafiltrates from epileptic patients.
    Clinical chemistry, 1985, Volume: 31, Issue:1

    Topics: Adult; Autoanalysis; Epilepsy; Female; Fluorescence Polarization; Humans; Immunoassay; Immunoenzyme

1985
Possible valproate teratogenicity.
    Archives of neurology, 1985, Volume: 42, Issue:3

    Topics: Abnormalities, Multiple; Epilepsy; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Neural

1985
Comparison of steady-state pharmacokinetics of valproic acid in children between monotherapy and multiple antiepileptic drug treatment.
    The Journal of pediatrics, 1985, Volume: 106, Issue:4

    Topics: Adolescent; Age Factors; Anticonvulsants; Child; Drug Therapy, Combination; Epilepsy; Female; Half-L

1985
Time-dependent interaction between phenytoin and valproic acid.
    Neurology, 1985, Volume: 35, Issue:4

    Topics: Adolescent; Adult; Child; Child, Preschool; Circadian Rhythm; Drug Interactions; Drug Therapy, Combi

1985
[Acute liver necrosis caused by valproate].
    Deutsche medizinische Wochenschrift (1946), 1985, Jun-14, Volume: 110, Issue:24

    Topics: Adult; Creatine Kinase; Epilepsy; Female; Humans; Liver Cirrhosis; Phenytoin; Transaminases; Valproi

1985
Effects of pregnancy on antiepileptic drug utilization.
    Epilepsia, 1985, Volume: 26 Suppl 1

    Topics: Anticonvulsants; Biological Availability; Carbamazepine; Epilepsy; Female; Humans; Kinetics; Metabol

1985
Adaptation of hepatic ammonia metabolism after chronic valproate administration in epileptics treated with phenytoin.
    European neurology, 1985, Volume: 24, Issue:3

    Topics: Adaptation, Physiological; Adult; Ammonia; Drug Interactions; Drug Therapy, Combination; Epilepsy; H

1985
Sodium valproate "encephalopathy": report of three cases with generalised epilepsy.
    Italian journal of neurological sciences, 1985, Volume: 6, Issue:1

    Topics: Adult; Arousal; Brain Diseases; Child; Confusion; Electroencephalography; Epilepsy; Female; Humans;

1985
Anticonvulsant drugs and the genetically epilepsy-prone rat.
    Federation proceedings, 1985, Volume: 44, Issue:10

    Topics: Acoustic Stimulation; Amitriptyline; Animals; Anticonvulsants; Carbamazepine; Desipramine; Disease M

1985
Valproic acid toxicity.
    American journal of diseases of children (1960), 1985, Volume: 139, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Epilepsy; Humans; Infant; Pancreati

1985
The effects of phenytoin and sodium valproate on the periodontal health of adult epileptic patients.
    Journal of clinical periodontology, 1985, Volume: 12, Issue:6

    Topics: Adolescent; Adult; Aged; Alveolar Process; Bone Resorption; Cross-Sectional Studies; Dental Plaque I

1985
Pharmacological evaluation of various metabolites and analogues of valproic acid. Anticonvulsant and toxic potencies in mice.
    Neuropharmacology, 1985, Volume: 24, Issue:5

    Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Disease Models, Animal; Epilepsy; Ethosuxim

1985
Drug compliance and seizure control in epileptic children.
    Postgraduate medical journal, 1985, Volume: 61, Issue:715

    Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Infan

1985
Monotherapy and polytherapy for intractable epilepsies.
    Italian journal of neurological sciences, 1985, Volume: 6, Issue:2

    Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbamazepine; Clobazam; D

1985
Sub-normal serum thyroxine levels associated with carbamazepine and valproic acid treatment.
    The Nebraska medical journal, 1985, Volume: 70, Issue:7

    Topics: Carbamazepine; Child; Diabetes Complications; Drug Therapy, Combination; Epilepsy; Humans; Male; Thy

1985
Spectral analysis of the EEG in children during the introduction of antiepileptic therapy with valproic acid.
    Neuropsychobiology, 1985, Volume: 13, Issue:1-2

    Topics: Adolescent; Child; Child, Preschool; Electroencephalography; Epilepsy; Epilepsy, Absence; Epilepsy,

1985
Interictal EEG prediction of response to antiepileptic drug monotherapy.
    Clinical EEG (electroencephalography), 1985, Volume: 16, Issue:3

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Electroencephalogr

1985
Improved direct injection method and extractive methylation method for determination of valproic acid in serum by gas chromatography.
    Journal of chromatography, 1985, Jul-12, Volume: 342, Issue:1

    Topics: Chromatography, Gas; Epilepsy; Humans; Methylation; Valproic Acid

1985
Longterm follow-up of childhood epilepsy with absences. I. Epilepsy with absences at onset.
    Neuropediatrics, 1985, Volume: 16, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsy; Epilepsy, Absence; Ethosuximi

1985
Evaluation of the effects of antiepileptic drugs on sleep-wakefulness patterns following 1 night total sleep deprivation in epileptic patients.
    Neuropsychobiology, 1985, Volume: 13, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Epilepsy; Human

1985
[Use of sodium valproate in children].
    Pediatriia, 1985, Issue:7

    Topics: Epilepsy; Humans; Infant; Seizures, Febrile; Valproic Acid

1985
Chronic valproic acid therapy and incidence of increases in venous plasma ammonia.
    Therapeutic drug monitoring, 1985, Volume: 7, Issue:3

    Topics: Adolescent; Adult; Aged; Ammonia; Carbamazepine; Child; Child, Preschool; Drug Interactions; Epileps

1985
[Clinical and electroencephalographic study of the effects of valpramide in treating epilepsy].
    Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry, 1985, Volume: 18, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Child; Electroencephalography; Epilepsy; Female; Humans; Male; M

1985
Valproic acid pharmacokinetics in children. II. Discontinuation of concomitant antiepileptic drug therapy.
    Neurology, 1985, Volume: 35, Issue:11

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Interactions; Epilepsy; Female; Humans; M

1985
The optimum use of anticonvulsants.
    The Practitioner, 1985, Volume: 229, Issue:1408

    Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Phen

1985
Effect of serum albumin on free fractions of phenobarbital and valproic acid in patients with convulsive seizures.
    Brain & development, 1985, Volume: 7, Issue:4

    Topics: Adolescent; Adult; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Female; Humans; Inf

1985
Alterations in transient visual-evoked potentials induced by clonazepam and sodium valproate.
    Neuropsychobiology, 1985, Volume: 14, Issue:1

    Topics: Adolescent; Adult; Benzodiazepinones; Brain; Child; Clonazepam; Epilepsy; Evoked Potentials, Visual;

1985
Where, why, and what type of therapy.
    Pediatric annals, 1985, Volume: 14, Issue:11

    Topics: Carbamazepine; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Hum

1985
Monitoring: the most important role of the pediatrician.
    Pediatric annals, 1985, Volume: 14, Issue:11

    Topics: Activities of Daily Living; Anticonvulsants; Carbamazepine; Child, Preschool; Environmental Monitori

1985
Serum concentrations of valproic acid: influence of dose and comedication.
    Therapeutic drug monitoring, 1985, Volume: 7, Issue:4

    Topics: Adolescent; Adult; Body Weight; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epileps

1985
Concentration of valproate during pregnancy, in the newborn and in breast milk.
    Acta neurologica Scandinavica, 1985, Volume: 72, Issue:5

    Topics: Adult; Body Weight; Epilepsy; Female; Fetal Blood; Humans; Kinetics; Maternal-Fetal Exchange; Milk,

1985
[Effects of valproate on mitochondrial function in epileptic patients].
    No to hattatsu = Brain and development, 1985, Volume: 17, Issue:6

    Topics: Adolescent; Ammonia; Carnitine; Child; Child, Preschool; Epilepsy; Humans; Lactates; Lactic Acid; Mi

1985
An improved gas liquid chromatographic assay for plasma valproic acid concentrations in mentally handicapped epileptic children.
    Methods and findings in experimental and clinical pharmacology, 1985, Volume: 7, Issue:11

    Topics: Child; Chromatography, Gas; Epilepsy; Humans; Neurocognitive Disorders; Valproic Acid

1985
Maternal epilepsy and birth defects: a case-control study in the Italian Multicentric Registry of Birth Defects (IPIMC).
    European journal of epidemiology, 1985, Volume: 1, Issue:1

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Chromosome Aberrations; Chromosome Disorders; Chromoso

1985
Use of total and free anticonvulsant serum levels in clinical practice.
    Clinical and experimental neurology, 1985, Volume: 21

    Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Immunoenzyme Techniques; Phenobarbital; Phenytoin;

1985
Valproate hepatotoxicity: a review and report of two instances in adults.
    Clinical and experimental neurology, 1985, Volume: 21

    Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Electroencephalography; Epilepsy; Humans;

1985
Progressive myoclonic epilepsy. The response to sodium di -- n -- propylacetate.
    Proceedings of the Australian Association of Neurologists, 1974, Volume: 11

    Topics: Adult; Epilepsy; Humans; Male; Myoclonus; Syndrome; Valerates; Valproic Acid

1974