valproic acid and Aura
valproic acid has been researched along with Aura in 2662 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Participants with focal epilepsy were randomised to receive lamotrigine, levetiracetam or zonisamide." | 9.41 | Lamotrigine versus levetiracetam or zonisamide for focal epilepsy and valproate versus levetiracetam for generalised and unclassified epilepsy: two SANAD II non-inferiority RCTs. ( Appleton, R; Baker, G; Balabanova, S; Brown, R; Burnside, G; Hindley, D; Howell, S; Hughes, DA; Leach, JP; Maguire, M; Marson, AG; Mohanraj, R; Plumpton, CO; Sills, G; Smith, D; Smith, PE; Taylor, C; Tudur-Smith, C; Williamson, PR, 2021) |
| "Hyperammonemia can occur after acute overdose or chronic use of valproic acid (VPA)." | 9.41 | Risk factors of hyperammonemia in epilepsy patients with valproic acid therapy. ( Kim, DW; Kwack, DW, 2023) |
| "This trial evaluated the effect of cannabidiol on steady-state pharmacokinetics of stiripentol or valproate in patients with epilepsy, and the safety and tolerability of cannabidiol." | 9.34 | A Phase II Randomized Trial to Explore the Potential for Pharmacokinetic Drug-Drug Interactions with Stiripentol or Valproate when Combined with Cannabidiol in Patients with Epilepsy. ( Arenas Cabrera, CM; Ben-Menachem, E; Critchley, D; Crockett, J; Gunning, B; Morrison, G; Tayo, B; Toledo, M; VanLandingham, K; Wray, L, 2020) |
| "To estimate the safety and efficacy of sodium valproate combined with levetiracetam in paediatric patients with epilepsy based on randomized controlled trials (RCTs)." | 9.22 | Combined effects of levetiracetam and sodium valproate on paediatric patients with epilepsy: a systematic review and meta-analysis. ( Yang, J; Zhu, X; Zhu, Y, 2022) |
| "A literature search was performed in the PubMed, Embase, and OVID-Medline databases to identify articles related to epilepsy and lamotrigine that were published from the establishment of the database to April 2021." | 9.22 | The efficacy of lamotrigine after failure of the first administration of valproate in treating epilepsy: a systematic review and meta-analysis. ( He, J; Wu, X; Zhou, D, 2022) |
| "This post-hoc subgroup analysis of data from an unblinded, randomized, 52-week superiority study (KOMET) compared the effectiveness of levetiracetam (LEV) with extended-release sodium valproate (VPA-ER) and controlled-release carbamazepine (CBZ-CR) as monotherapy in patients aged ≥ 60 years with newly diagnosed epilepsy." | 9.22 | Comparative effectiveness of levetiracetam, valproate and carbamazepine among elderly patients with newly diagnosed epilepsy: subgroup analysis of the randomized, unblinded KOMET study. ( Marson, AG; Noack-Rink, M; Pohlmann-Eden, B; Ramirez, F; Tofighy, A; Trinka, E; Werhahn, KJ; Wild, I, 2016) |
| "This Phase I, open-label, dose-escalation study investigated the effects of steady-state brivaracetam on the pharmacokinetics of carbamazepine in patients with epilepsy, with and without valproate co-administration." | 9.22 | Pharmacokinetic interaction of brivaracetam on carbamazepine in adult patients with epilepsy, with and without valproate co-administration. ( Brodie, MJ; Sargentini-Maier, ML; Stockis, A, 2016) |
| "Eighty-one patients participated in the study: 51 patients with chronic epilepsy (G1) treated with carbamazepine (CBZ) or valproic acid (VPA), and 30 patients with newly diagnosed epilepsy (G2)." | 9.16 | The effect of vitamin B supplementation on homocysteine metabolism and clinical state of patients with chronic epilepsy treated with carbamazepine and valproic acid. ( Bochyńska, A; Graban, A; Gugała-Iwaniuk, M; Lechowicz, W; Lipczyńska-Łojkowska, W; Lipska, B; Restel, M; Ryglewicz, D, 2012) |
| "This study aimed to evaluate the effects of monotherapy with valproate or oxcarbazepine on the linear growth of children with idiopathic epilepsy." | 9.16 | The effects of oxcarbazepine and valproate therapies on growth in children with epilepsy. ( Bideci, A; Camurdan, O; Cansu, A; Cinaz, P; Hirfanoglu, TL; Karaoglu, A; Serdaroglu, A; Yesilkaya, E, 2012) |
| "Two broad spectrum AEDs, the traditional drug of sustained-release formulation of valproate (SRVPA) and the new-generation drug of topiramate, were compared in patients with epilepsy as monotherapy in this multi-centre, observational cohort study from 2000 to 2011." | 9.16 | Outcomes of sustained-release formulation of valproate and topiramate monotherapy in patients with epilepsy: a multi-centre, cohort study. ( Cao, Q; Chen, G; Ding, M; Hu, X; Hu, Y; Huang, X; Li, H; Liu, J; Lu, Y; Peng, B; Shen, D; Sun, H; Wang, X; Wu, M; Xi, Z; Zeng, K; Zhang, Y; Zhou, Y, 2012) |
| "To investigate the effect of topiramate on bone mass and metabolism in premenopausal women with epilepsy." | 9.15 | The effect of topiramate monotherapy on bone mineral density and markers of bone and mineral metabolism in premenopausal women with epilepsy. ( Heo, K; Kim, WJ; Lee, BI; Lee, HW; Lee, SA; Rhee, Y; Shin, DJ; Song, HK; Song, K, 2011) |
| "This open label study suggests that the combination of valproate, lamotrigine, and a benzodiazepine can markedly reduce the frequency of epileptic drop attacks in patients with generalized or multifocal epilepsies." | 9.15 | Long-term control of epileptic drop attacks with the combination of valproate, lamotrigine, and a benzodiazepine: a 'proof of concept,' open label study. ( Bastos, FA; Machado, VH; Palmini, A; Rotert, R, 2011) |
| "To explore efficacy and tolerability outcomes of topiramate (TPM) in patients with epilepsy transitioning from valproic acid (VPA) because of insufficient efficacy and/or tolerability onto TPM." | 9.14 | Conversion from valproic acid onto topiramate in adolescents and adults with epilepsy. ( Bogdanow, M; Lüer, W; Ossig, W; Schauble, B; Schreiner, A; Stollhoff, K; Unkelbach, S, 2009) |
| " We evaluated the reproductive endocrine and insulin-related metabolic parameters in men and women with untreated epilepsy randomized to valproate (n=44) or lamotrigine (n=37) monotherapy for 12 months." | 9.14 | Effects of valproate or lamotrigine monotherapy on the reproductive endocrine and insulin-related metabolic profile in Chinese adults with epilepsy: a prospective randomized study. ( Chan, IH; Chan, MH; Hui, AC; Hui, KF; Kwan, P; Lam, CW; Leung, H; Ng, PW; Yip, FP, 2009) |
| "Valproate (VPA) administration may be associated with adverse metabolic effects, among is hyperammonemia, which could suggest metabolic abnormalities as carnitine deficiency." | 9.14 | The risk of asymptomatic hyperammonemia in children with idiopathic epilepsy treated with valproate: relationship to blood carnitine status. ( Abdella, MM; Hamed, SA, 2009) |
| "For a retrospective observational investigation based on real clinical practice of relative efficacy of valpoic acid (VPA), carbamazepine (CBZ) and topiramate (TPM) we have selected 106 patients with age of seizure onset before 17 years with a undoubted diagnosis of symptomatic or cryptogenic occipital lobe epilepsy (OLE), who had received treatment according to ILAE recommendations, and observation time since the last treatment change was from 2 to 10 years." | 9.14 | [Comparative efficacy of carbamazepine, valproic acid and topiramate in symptomatic and cryptogenic occipital lobe epilepsy in children]. ( , 2010) |
| "To evaluate development of components of polycystic ovary syndrome (PCOS) and PCOS in women with epilepsy initiating valproate or lamotrigine therapy." | 9.13 | Hyperandrogenism, ovulatory dysfunction, and polycystic ovary syndrome with valproate versus lamotrigine. ( Adams, JM; Bhatt, M; Hayes, FJ; Isojärvi, J; Morrell, MJ; Ozkara, C; Sluss, PM; Warnock, CR, 2008) |
| "To evaluate the efficacy and tolerability of the treatment with valproic acid (VPA) in patients with status epilepticus (SE) or acute repetitive seizures (ARS) comparing it with phenytoin (PHT) treatment." | 9.13 | Treatment of status epilepticus and acute repetitive seizures with i.v. valproic acid vs phenytoin. ( Dabby, R; Gilad, R; Izkovitz, N; Lampl, Y; Rapoport, A; Sadeh, M; Weller, B, 2008) |
| "The present study was designed to reveal changes of cognitive processes in epilepsy (EP) patients with Topiramate (TPM) or Valproate (VPA) treatment using Wechsler Adult Intelligence Scale (WAIS-CR) and event-related potential (ERP)." | 9.13 | Attention changes in epilepsy patients following 3-month topiramate or valproate treatment revealed by event-related potential. ( Sun, W; Wang, W; Wang, Y; Wu, X, 2008) |
| " This paper aims to undertake a comprehensive review regarding the possible risks of four classical (phenytoin, carbamazepine, phenobarbital, and valproate) and two newer (lamotrigine and levetiracetam) AEDs during pregnancy." | 9.12 | Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications. ( Demir, O; Kaplan, YC, 2021) |
| "This study was performed to evaluate carnitine deficiency in a large series of epilepsy children and adolescents treated with old and new antiepileptic drugs with or without ketogenic diet." | 9.12 | Plasma free carnitine in epilepsy children, adolescents and young adults treated with old and new antiepileptic drugs with or without ketogenic diet. ( Auricchio, G; Coppola, G; Epifanio, G; Federico, RR; Pascotto, A; Resicato, G, 2006) |
| "In eight women treated with lamotrigine monotherapy, the lamotrigine dose/plasma concentration (D/C) ratio increased by 295% from baseline outside pregnancy to midgestation, whereas in six women treated with lamotrigine in combination with valproate, the increase was only 60%." | 9.12 | Valproate effects on kinetics of lamotrigine in pregnancy and treatment with oral contraceptives. ( Luef, G; Ohman, I; Pittschieler, S; Sabers, A; Tomson, T, 2006) |
| "We have performed a randomised, prospective study to compare the efficacy and tolerability of sodium valproate (VPA) and lamotrigine (LTG) monotherapy, and their effects on circulating androgenic hormones, in newly diagnosed epilepsy." | 9.12 | Sodium valproate versus lamotrigine: a randomised comparison of efficacy, tolerability and effects on circulating androgenic hormones in newly diagnosed epilepsy. ( Brodie, MJ; Butler, E; Hitiris, N; Leach, JP; Leach, VM; Parker, P; Sills, GJ; Stephen, LJ; Wilson, EA, 2007) |
| "To determine whether levetiracetam (LEV) affects plasma concentrations of carbamazepine, valproic acid, topiramate, and lamotrigine in children with epilepsy." | 9.12 | Lack of pharmacokinetic interaction of levetiracetam on carbamazepine, valproic acid, topiramate, and lamotrigine in children with epilepsy. ( De Smedt, H; Otoul, C; Stockis, A, 2007) |
| " The aim of this study was to evaluate thyroid function in 78 girls taking carbamazepine (CBZ), oxcarbazepine (OXC), or valproate (VPA) monotherapy for epilepsy and after withdrawal of the treatment." | 9.11 | Thyroid function in girls with epilepsy with carbamazepine, oxcarbazepine, or valproate monotherapy and after withdrawal of medication. ( Isojärvi, JI; Knip, M; Mikkonen, K; Myllylä, VV; Pakarinen, AJ; Rättyä, J; Vainionpää, LK, 2004) |
| "In a novel double-blind trial, topiramate was compared with the investigator's choice of carbamazepine or valproate as first-line therapy in patients as young as 6 years of age with newly diagnosed epilepsy." | 9.11 | Topiramate, carbamazepine, and valproate monotherapy: double-blind comparison in children with newly diagnosed epilepsy. ( Neto, W; Wang, S; Wheless, JW, 2004) |
| "This randomized, open-label study was designed to compare the efficacy and tolerability of lamotrigine monotherapy with those of valproate and carbamazepine monotherapy in patients with epilepsy whose seizures were uncontrolled on their prestudy antiepileptic drug monotherapy." | 9.11 | Efficacy and tolerability of conversion to monotherapy with lamotrigine compared with valproate and carbamazepine in patients with epilepsy. ( Fakhoury, TA; Hammer, AE; Messenheimer, JA; Vuong, A, 2004) |
| "A dosing algorithm was used to guide the conversion of 77 patients with epilepsy (16 years of age) from valproate monotherapy through lamotrigine adjunctive therapy at 200mg daily to lamotrigine monotherapy at 500 mg daily in an open-label study comprising a lamotrigine escalation phase (8 weeks), a valproate withdrawal phase (6 weeks), and a lamotrigine monotherapy phase (4 weeks)." | 9.11 | A dosing algorithm for converting from valproate monotherapy to lamotrigine monotherapy in patients with epilepsy. ( Biton, V; Blum, D; Hammer, AE; Messenheimer, JA; Natarajan, S; Sale, ME; Vuong, A, 2005) |
| "To compare topiramate (TPM) with investigator's choice of carbamazepine (CBZ) or valproate (VPA) for initial treatment in patients with newly diagnosed epilepsy." | 9.10 | Topiramate, carbamazepine and valproate monotherapy: double-blind comparison in newly diagnosed epilepsy. ( Brodie, MJ; Chadwick, DW; Mattson, RH; Neto, W; Privitera, MD; Wang, S, 2003) |
| "The authors assessed the effect of concomitant antiepileptic therapy on steady-state plasma concentrations of the new antiepileptic drug (AED) topiramate and the potential relation between topiramate plasma levels and side effects in a cohort of 116 patients with epilepsy." | 9.10 | Topiramate therapeutic monitoring in patients with epilepsy: effect of concomitant antiepileptic drugs. ( Albani, F; Avoni, P; Baruzzi, A; Contin, M; Riva, R, 2002) |
| "We studied the efficacy of felbamate (FBM) in combination with valproic acid (VPA) in 13 patients with the Lennox-Gastaut syndrome and evaluated the contribution of each drug." | 9.09 | The efficacy of felbamate as add-on therapy to valproic acid in the Lennox-Gastaut syndrome. ( Flamini, R; Gaillard, WD; Kelley, K; Ko, D; Malow, B; Reeves-Tyer, P; Siegel, H; Stertz, B; Theodore, WH, 1999) |
| "5-18 yrs with intractable epilepsy and comedicated with carbamazepine or valproate." | 9.09 | Plasma and urinary serotonin and 5-HIAA in children treated with lamotrigine for intractable epilepsy. ( Jović, NJ; Majkić-Singh, N; Milovanović, DD; Mirković, D, 1999) |
| "to describe the population pharmacokinetics of lamotrigine (LTG) in developmentally disabled (DD) patients with epilepsy and (2) to determine if there is an effect of valproate (VPA) concentration on the extent of the pharmacokinetic interaction between VPA and LTG." | 9.09 | Lack of an effect of valproate concentration on lamotrigine pharmacokinetics in developmentally disabled patients with epilepsy. ( Anderson, GD; Gidal, BE; Lanning, A; Rutecki, PR; Shaw, R, 2000) |
| " The primary aim of the study was to evaluate lamotrigine add-on therapy and consecutive monotherapy in patients with epilepsy whose seizures were not controlled by carbamazepine or valproate." | 9.09 | Open study evaluating lamotrigine efficacy and safety in add-on treatment and consecutive monotherapy in patients with carbamazepine- or valproate-resistant epilepsy. ( Jozwiak, S; Terczynski, A, 2000) |
| "Lamotrigine (LTG) is one of the newer antiepileptic drugs which has been shown to have a spectrum of drug interactions (including with other epilepsy drugs) that can have a pronounced effect on LTG kinetics." | 9.09 | Clinical study of lamotrigine and valproic acid in patients with epilepsy: using a drug interaction to advantage? ( Black, AB; Lam, E; Morris, RG; Westley, IS, 2000) |
| "To compare the incidence and magnitude of change in body weight associated with lamotrigine or divalproex sodium monotherapy in patients with epilepsy." | 9.09 | Weight change associated with valproate and lamotrigine monotherapy in patients with epilepsy. ( Barrett, PS; Biton, V; Hammer, AE; Mirza, W; Montouris, G; Vuong, A, 2001) |
| "We retrospectively evaluated the ability of Scatchard binding equation method to predict the unbound serum valproic acid (VPA) concentration in 37 pediatric patients with epilepsy receiving VPA monotherapy." | 9.08 | Evaluation of binding equation method for prediction of unbound serum valproic acid concentration in pediatric patients with epilepsy. ( Fujii, I; Kodama, H; Kodama, Y; Koike, Y; Kuranari, M; Takeyama, M; Yasunaga, F, 1995) |
| "To assess the effects of carbamazepine vs valproate sodium on cognitive functioning in patients with epilepsy compared with normal control subjects." | 9.08 | Effect of valproate on cognitive functioning. Comparison with carbamazepine. The Department of Veterans Affairs Epilepsy Cooperative Study 264 Group. ( Cattanach, L; Collins, JF; Cramer, JA; Delaney, RC; Mattson, RH; Prevey, ML, 1996) |
| " This paper presents an analysis of body weight data gathered during a randomized trial comparing valproate with carbamazepine in 260 children aged 4-15 years with newly-diagnosed epilepsy." | 9.08 | Weight gain with valproate or carbamazepine--a reappraisal. ( Easter, D; O'Bryan-Tear, CG; Verity, C, 1997) |
| "We have analyzed the records retrospectively and interviewed 70 adult patients attending an epilepsy clinic on VPA mono- or polytherapy followed over a median of 27 months (range 3-189), as well as 20 patients on carbamazepine (CBZ) monotherapy." | 9.08 | Weight gain in epileptic patients during treatment with valproic acid: a retrospective study. ( Corman, CL; Guberman, AH; Leung, NM, 1997) |
| "We report the results of an open trial with lamotrigine (LTG) as add-on drug in children and adolescents with refractory epilepsy and mental delay." | 9.08 | Lamotrigine as add-on drug in children and adolescents with refractory epilepsy and mental delay: an open trial. ( Coppola, G; Pascotto, A, 1997) |
| "To evaluate population pharmacokinetics and the relationship between plasma concentration and daily dose of valproic acid (VPA) in a homogeneous group of children with epilepsy." | 9.08 | Valproic acid clearance in children with epilepsy. ( López, E; Quintana, MB; Rodríguez, I; Sánchez-Alcaraz, A, 1998) |
| "Sixty-four new cases of childhood epilepsy were randomly assigned to either carbamazepine, phenytoin or sodium valproate, and were assessed with behavioural measures before medication and after one and six months of treatment." | 9.07 | Psychiatric aspects of epilepsy in childhood treated with carbamazepine, phenytoin or sodium valproate: a random trial. ( Berg, I; Butler, A; Ellis, M; Foster, J, 1993) |
| "Thirteen children with intractable epilepsy were treated by means of three-times-daily administration of a conventional preparation of valproic acid (C-VPA) and twice-daily administration of a new slow-release preparation of VPA (SR-VPA) with the cross-over technique." | 9.07 | A comparative clinical and pharmacokinetic study of a new slow-release versus conventional preparations of valproic acid in children with intractable epilepsy. ( Fukuyama, Y; Imaizumi, T; Izumi, T, 1992) |
| "The effects of adding vigabatrin (GVG) to the antiepileptic regimens of 16 children with refractory epilepsy have been studied." | 9.07 | Coadministration of vigabatrin and valproate in children with refractory epilepsy. ( Armijo, JA; Arteaga, R; Herranz, JL; Valdizán, EM, 1992) |
| "Sixty-four new cases of childhood epilepsy were randomly assigned to either carbamazepine, phenytoin or sodium valproate, and were assessed with cognitive tests before medication and three subsequent times over a year." | 9.07 | Cognitive impairment in new cases of epilepsy randomly assigned to carbamazepine, phenytoin and sodium valproate. ( Berg, I; Butler, R; Forsythe, I; McGuire, R, 1991) |
| "Taltrimide was compared with valproate and placebo in 17 patients with intractable epilepsy being on carbamazepine monotherapy." | 9.06 | A controlled study with taltrimide and sodium valproate: valproate effective in partial epilepsy. ( Allonen, H; Iivanainen, M; Neuvonen, PJ; Parantainen, J; Tamminen, M; Tokola, O; Waltimo, O, 1990) |
| "Long-term use of valproic acid in treating children with epilepsy can lead to a reduction in 25-OH-VitD and BMD." | 9.05 | Effects of valproic acid on skeletal metabolism in children with epilepsy: a systematic evaluation and meta-analysis based on 14 studies. ( Biaoxue, R; Chunyan, W; Min, L, 2020) |
| "We evaluated valproic acid (VPA) for 6 months as therapy for uncontrolled seizures in 100 children, 38 with partial and 62 with generalized epilepsy." | 9.05 | Treatment of childhood epilepsy with valproic acid: results of the first 100 patients in a 6-month trial. ( Couri, D; Sherard, ES; Steiman, GS, 1980) |
| "Valproic acid (VPA) as a widely used primary medication in the treatment of epilepsy is associated with reversible or irreversible hepatotoxicity." | 9.01 | Valproic Acid and the Liver Injury in Patients with Epilepsy: An Update. ( Chen, F; Guo, HL; Hu, YH; Jing, X; Lu, XP; Ni, MM; Qiu, JC; Sun, JY; Wang, T; Xu, ZJ, 2019) |
| "We systematically reviewed studies to provide current evidence about the incidence and risk of alopecia in patients undergoing valproic acid (VPA) therapy." | 9.01 | Risk of valproic acid-related alopecia: A systematic review and meta-analysis. ( Liu, L; Wang, H; Wang, X; Xu, D; Zhu, L, 2019) |
| "Valproic acid (VPA) is frequently used in the treatment of epilepsy." | 9.01 | CPS1 T1405N polymorphism, HDL cholesterol, homocysteine and renal function are risk factors of VPA induced hyperammonemia among epilepsy patients. ( Chen, D; Chen, L; Chen, P; Gao, X; Li, C; Li, H; Li, Y; Tian, Q; Tian, X; Wen, J; Yang, H; Zhang, M, 2019) |
| "Lamotrigine is used in pregnancy to control epilepsy and mood disorders." | 8.95 | Pregnancy Outcomes Following In Utero Exposure to Lamotrigine: A Systematic Review and Meta-Analysis. ( Adams-Webber, T; Barzilay, E; Leibson, T; Nulman, I; Pariente, G; Shulman, T, 2017) |
| "To determine whether valproate (VPA) monotherapy influences homocysteine metabolism in patients with epilepsy." | 8.90 | Increased homocysteine levels in valproate-treated patients with epilepsy: a meta-analysis. ( Chen, Y; Chen, Z; Fang, Z; Ni, G; Qin, J; Zhou, J; Zhou, L, 2014) |
| "In the last years, a growing body of literature indicates an association between valproic acid therapy and weight gain." | 8.87 | Weight gain following treatment with valproic acid: pathogenetic mechanisms and clinical implications. ( Chiarelli, F; Coppola, G; D'Egidio, C; Mohn, A; Verrotti, A, 2011) |
| " The present study aims to determine the distribution pattern of UGT1A6 and UGT2B7 gene polymorphism and its possible impact on the metabolism of valproic acid (VPA) and carbamazepine (CBZ) in patients with epilepsy from Khyber Pakhtunkhwa region of Pakistan." | 8.84 | Distribution pattern of UGT1A6 and UGT2B7 gene polymorphism and its impact on the pharmacokinetics of valproic acid and carbamazepine: Prospective genetic association study conducted in Pakistani patients with epilepsy. ( Ali, N; Almarshad, F; Alshahrani, AM; Jamil, A; Saleh Faisal, M, 2024) |
| "The author reports one case of pseudocyst of the pancreas, an uncommon disorder in children, secondary to pancreatitis in a 9-year-old girl treated with valproic acid for epilepsy." | 8.82 | Pancreatic pseudocyst caused by valproic acid: case report and review of the literature. ( Hernández, F; Queizán, A; Rivas, S, 2003) |
| "Valproic acid (VPA) is a commonly prescribed medication approved for use in the United States for epilepsy, migraine, and bipolar disorder." | 8.82 | Acute pancreatitis in children from Valproic acid: case series and review. ( Feldman-Winter, LB; Goldfarb, O; Grauso-Eby, NL; McAbee, GN, 2003) |
| " However, a particular association of valproate and carbamazepine with neural tube defects (NTDs)--specifically, with spina bifida aperta (SB)--has been identified." | 8.82 | Management issues for women with epilepsy: neural tube defects and folic acid supplementation. ( Yerby, MS, 2003) |
| "To correlate lamotrigine (LTG) serum concentrations (levels) with tolerability in patients with epilepsy." | 8.82 | Correlating lamotrigine serum concentrations with tolerability in patients with epilepsy. ( Adams, DJ; Bazil, CW; Buchsbaum, R; Du, Y; Hager, M; Hirsch, LJ; Morrell, MJ; Resor, SR; Spencer, HT; Straka, T; Weintraub, D, 2004) |
| "A 12-year-old boy developed pancreatitis, complicated by a pancreatic pseudocyst, as an adverse reaction to valproic acid (VPA) treatment for epilepsy." | 8.82 | Pancreatitis, complicated by a pancreatic pseudocyst associated with the use of valproic acid. ( Houben, ML; Stroink, H; van Dijken, PJ; Wilting, I, 2005) |
| "To provide an overview of the evidence comparing carbamazepine (CBZ) and valproate (VPA) monotherapy for epilepsy, investigating whether existing data support the current practice of preferring CBZ for partial-onset and VPA for generalized-onset seizures." | 8.81 | Carbamazepine versus valproate monotherapy for epilepsy: a meta-analysis. ( Chadwick, DW; Clough, H; Hutton, JL; Marson, AG; Williamson, PR, 2002) |
| "Carbamazepine and valproate are drugs of first choice for epilepsy." | 8.80 | Carbamazepine versus valproate monotherapy for epilepsy. ( Chadwick, DW; Clough, HE; Hutton, JL; Marson, AG; Williamson, PR, 2000) |
| "We reported a case of acute pancreatitis occurring during administration of valproic acid for epilepsy." | 8.78 | [A case of acute pancreatitis during administration of valproic acid]. ( Ito, S; Kobayashi, K; Kuniya, T; Mimasu, S; Momota, T, 1993) |
| "An 11 year-old epileptic boy, treated with valproic acid developed after 11 months on therapy a severe acute pancreatitis." | 8.78 | [Acute pancreatitis and valproic acid]. ( Bovier Lapierre, M; Jalaguier, E; Kayemba Kay's Kabangu, S, 1991) |
| "Resistance to valproic acid (VPA) is a major challenge for epilepsy treatment." | 8.31 | Overexpression of Homer1b/c induces valproic acid resistance in epilepsy. ( Li, Y; Li, Z; Lu, J; Wang, G; Wang, Y, 2023) |
| "Valproic acid (VPA)-induced hyperammonemia (HA) is a rare adverse effect reported even at therapeutic VPA levels." | 8.31 | Valproic acid-induced hyperammonemia in neuropsychiatric disorders: a 2-year clinical survey. ( Aghamollaii, V; Ghayyem, H; Hassani, M; Hosseini, H; Mayeli, M; Shafie, M; Shakiba, A, 2023) |
| "To investigate the efficacy and mechanisms of Dingxian pill combined with valproic acid (VPA) on pentylenetetrazol-induced chronical epilepsy in rats." | 8.31 | Efficacy and mechanisms of Dingxian pill combined with valproic acid on pentylenetetrazol-induced chronic epilepsy in rats. ( Dongxiao, QU; Guoyi, LI; Jie, T; Jiwei, C; Liji, C; Limin, Z; Qian, X; Yiqin, GE; Yonghua, X; Yudan, Z, 2023) |
| "To investigate the antiseizure medication (ASM) doses required to achieve seizure freedom and their correlation with the World Health Organization's defined daily doses (DDDs) in patients aged 16 years or older with newly diagnosed epilepsy." | 8.31 | Prescribed antiseizure medication doses and their relation to defined daily doses for achieving seizure freedom in newly diagnosed patients with epilepsy. ( Hersi, H; Peltola, J; Raitanen, J; Saarinen, JT, 2023) |
| "Valproic acid (VPA) is a relatively safe drug widely used for the treatment of epileptic seizures and mania in bipolar disorder, as well as the prevention of migraine headaches." | 8.31 | Acute pancreatitis during valproic acid administration in a patient with vascular dementia, epileptic seizures, and psychiatric symptoms: a case report. ( Harada, M; Hashimoto, R; Igata, R; Ikenouchi, A; Isomoto, N; Konishi, Y; Okamoto, N; Shinkai, T; Yanaga, M; Yoshimura, R, 2023) |
| "A prospective longitudinal study was conducted to assess the Apo B100/A1 ratio as a marker of cardiovascular risk in children with epilepsy aged 5-14 years on long-term anti-seizure medication monotherapy with either sodium valproate, oxcarbazepine, or levetiracetam." | 8.31 | Change in Apo B100/A1 Ratio in Children With Epilepsy on Monotherapy With Sodium Valproate, Oxcarbazepine or Levetiracetam. ( Dhama, A; Kaushik, JS; Lekhwani, S, 2023) |
| "Dose-adjusted lamotrigine troughs in epilepsy patients with variant UGT2B7 -161C > T or UGT1A4*3 c." | 8.31 | Bearing variant alleles at uridine glucuronosyltransferase polymorphisms UGT2B7 -161C > T (rs7668258) or UGT1A4*3 c.142 T > G (rs2011425) has no relevant consequences for lamotrigine troughs in adults with epilepsy. ( Božina, N; Domjanović, IK; Gadže, ŽP; Ganoci, L; Lovrić, M; Romić, ZČ; Šimičević, L; Sporiš, IŠ; Trkulja, V, 2023) |
| " The aim of this study was to explore the association of SCN1A polymorphisms with efficacy and adverse drug reactions (ADRs) related to valproic acid (VPA) among Chinese children with epilepsy." | 8.31 | SCN1A Polymorphisms and Haplotypes Are Associated With Valproic Acid Treatment Outcomes in Chinese Children With Epilepsy. ( Fan, X; Guo, H; He, Y; Li, W; Lu, J; Shen, X; Xia, H; Zhang, J; Zhu, J, 2023) |
| "Valproic acid (VPA) and levetiracetam (LEV) are used in epilepsy treatment." | 8.12 | Successful Treatment of Symptomatic Epilepsy with Oral Valproic Acid and Levetiracetam in a Patient with Short-bowel Syndrome. ( Hayashi, M; Iijima, A; Isozaki, R; Kurishima, A; Shimozato, R; Shioda, T, 2022) |
| "Valproic acid (VPA) is used for the treatment of epilepsy and bipolar disorder (BD)." | 8.12 | Long-term use of valproic acid reduced mortality in bipolar disorder patients in a Taiwanese population: An association analysis using the national health insurance research database (NHIRD). ( Hsieh, TC; Lin, CC; Wu, LS, 2022) |
| "In a nation-wide population-based longitudinal register linkage study for the first time 1) to investigate long-term response to lithium in patients with bipolar disorder with and without comorbid epilepsy, and 2) within patients with bipolar disorder and comorbid epilepsy to compare differences in responses between lithium, valproate and lamotrigine." | 8.12 | Response to lithium and anticonvulsants among patients with bipolar disorder with and without comorbid epilepsy - A nation-wide population-based longitudinal study. ( Budtz-Jørgensen, E; Gerds, T; Kessing, LV; Ziersen, SC, 2022) |
| " Here we examine the effects of valproic acid (VA) plus 4-phenylbutyric acid (4-PBA) on abnormal electrical brain activity, ER stress and apoptosis in acute seizures induced by pentylenetetrazole (PTZ)." | 8.12 | 4-Phenylbutyric Acid Plus Valproic Acid Exhibits the Therapeutic and Neuroprotective Effects in Acute Seizures Induced by Pentylenetetrazole. ( Amanvermez, R; Arslan, G; Gün, S; Rzayev, E; Tiryaki, ES, 2022) |
| "AbstractThe aim of this study was to explore the effect of lamotrigine (LTG) on blood ammonia level in patients with epilepsy and identify risk factors affecting blood ammonia level." | 8.12 | Risk factors of elevated blood ammonia level in epilepsy patients treated with lamotrigine. ( Chen, J; Chen, X; Chen, Y; Miao, J; Wang, R; Zeng, J; Zhuang, X, 2022) |
| " Consecutive adolescent patients with epilepsy aged 11-17 years with partial or generalized seizures, treated with either levetiracetam or valproic acid for at least 6 months, and healthy controls were recruited." | 8.12 | Irritability and its relationship with psychosocial symptoms and quality of life in adolescents with epilepsy receiving levetiracetam therapy: A case-control study. ( Tekin, E; Tekin, U; Uçar, HN, 2022) |
| "To compare the hazard for all-cause mortality and mortality due to heart failure (HF) between valproate (VPA) and levetiracetam (LEV)/lamotrigine (LTG) users in patients aged ≥ 65 with comorbidities of epilepsy and HF." | 8.12 | The Relationship Between Valproate and Lamotrigine/Levetiracetam Use and Prognosis in Patients With Epilepsy and Heart Failure: A Danish Register-Based Study. ( Gardella, E; Kragholm, K; Liang, D; Polcwiartek, C; Sessa, M, 2022) |
| "To study the association between CYP2C19*2 (681 G > A) and UGT1A6*2 (552A > C) polymorphisms on Valproic acid (VPA)-induced weight gain in People with epilepsy (PWE)." | 8.02 | CYP2C19 & UGT1A6 genetic polymorphisms and the impact on Valproic acid-induced weight gain in people with epilepsy: Prospective genetic association study. ( Kamalanathan, S; Kesavan, R; Mani, B; Nair, PP; Narayan, SK; Sekhar, A, 2021) |
| "A retrospective chart review conducted at King Abdulaziz University Hospital, Jeddah, Kingdome of Saudi Arabia, for children below 2 years of age diagnosed with epilepsy and treated with valproic acid from January 2016 to January 2020." | 8.02 | Valproic acid for children below 2 years of age with epilepsy. ( Alfawaz, NS; Almahmudi, SM; Alrabghi, MO; Bin Mahfouz, MM; Muthaffar, OY, 2021) |
| "Children aged 1 to 12 years, diagnosed with epilepsy (generalized or focal seizures), treated with valproate (n = 40) and valproate with add-on levetiracetam (n = 40) were included." | 8.02 | Effect of valproate and add-on levetiracetam on inflammatory biomarkers in children with epilepsy. ( Gupta, R; Halder, S; Kar, R; Labh, R; Narang, M, 2021) |
| "The purpose of this study was to establish a protein binding model of unbound valproic acid (VPA) based on Chinese pediatric patients with epilepsy and provide a reference for clinical medication." | 8.02 | Population pharmacokinetics of unbound valproic acid in pediatric epilepsy patients in China: a protein binding model. ( Gu, X; Hu, Y; Jiao, Z; Li, Z; Ma, M; Peng, Q; Sheng, C; Yu, S; Zhou, B; Zhu, M, 2021) |
| " In the pharmacodynamic interaction study, seizures were induced using pentylenetetrazole (PTZ) (60 mg/kg, i." | 8.02 | Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats. ( Agarwal, A; Arora, R; Ganeshan N, S; Gupta, YK; Kaleekal, T; Kumar, R; Sarangi, SC, 2021) |
| "We measured carnitine levels before and after pivalate-conjugated antibiotic (PCA) use in six patients with epilepsy who were prescribed valproate (VPA)." | 8.02 | Carnitine supplementation prevents carnitine deficiency caused by pivalate-conjugated antibiotics in patients with epilepsy prescribed valproate. ( Azuma, Y; Iwayama, H; Kurahashi, H; Numoto, S; Okumura, A, 2021) |
| "Overall, serum free carnitine levels showed significant negative correlations with epilepsy duration, VPA treatment duration, daily VPA dose, and blood VPA concentration." | 8.02 | Factors associated with blood carnitine levels in adult epilepsy patients with chronic valproic acid therapy. ( Miyaoka, H; Saito, M; Takizawa, T, 2021) |
| "Although several studies have indicated that valproate (VPA) and oxcarbazepine (OXC) cause reproductive endocrine disorders and sexual dysfunction, there remains some controversy regarding these issues in males with epilepsy." | 8.02 | A Comparative Study of the Effects of Valproate and Oxcarbazepine on Sexual Function, Sperm Quality, and Sex Hormones in Males with Epilepsy. ( Chen, L; Guo, Y; Sun, H; Wu, D; Yu, L; Zhu, Q, 2021) |
| "We measured the serum-free carnitine (FC), VPA, aspartate aminotransferase, alanine aminotransferase, amylase, and ammonia levels, and the platelet count, in 69 patients with childhood-onset epilepsy treated with VPA." | 8.02 | Effects of l-carnitine supplementation in patients with childhood-onset epilepsy prescribed valproate. ( Azuma, Y; Iwayama, H; Kurahashi, H; Numoto, S; Okumura, A; Takagi, M, 2021) |
| "The aim of the study was to investigate the risk of subclinical atherosclerosis independent from obesity and high blood lipid levels in pediatric patients with idiopathic epilepsy receiving valproic acid or levetiracetam monotherapy by evaluating carotid intima-media thickness (CIMT) and Epicardial adipose tissue thickness (EATT)." | 7.96 | Effects of valproic acid and levetiracetam monotherapy on carotid intima-media and epicardial adipose tissue thickness in non-obese children with epilepsy. ( Karatoprak, E; Tosun, O, 2020) |
| "We sought to explore the effects of sodium valproate combined with lamotrigine on quality of life and serum inflammatory factors in patients with poststroke secondary epilepsy." | 7.96 | Effects of Sodium Valproate Combined with Lamotrigine on Quality of Life and Serum Inflammatory Factors in Patients with Poststroke Secondary Epilepsy. ( Guo, D; Hao, F; Li, X; Liu, X; Sun, J; Tang, W; Tao, S, 2020) |
| "The aim of the study was to investigate how age and genetic polymorphisms of UGT1A6 and UGT2B7 contribute to the concentrations of valproic acid (VPA) and its hepatotoxic metabolites in Chinese pediatric patients with epilepsy." | 7.96 | Impact of Age and Genotype on Serum Concentrations of Valproic Acid and Its Hepatotoxic Metabolites in Chinese Pediatric Patients With Epilepsy. ( Chen, Y; Li, G; Wang, M; Zhao, L; Zhao, M, 2020) |
| "Here, we present a multicenter series of patients with developmental and epileptic encephalopathies (DEE) and related electroclinical patterns (REP) other than Lennox-Gastaut syndrome (LGS) who were treated with rufinamide as add-on therapy." | 7.96 | Rufinamide as add-on therapy in children with epileptic encephalopathies other than Lennox-Gastaut syndrome: A study of 34 patients. ( Caraballo, RH; Espeche, A; Fasulo, L; Galichio, S; Pociecha, J; Reyes, G; Semprino, M, 2020) |
| "These findings suggest that carnitine deficiency is associated with the VPA dose and the serum VPA level in patients with bipolar disorder." | 7.96 | Association Between the Serum Carnitine Level and Ammonia and Valproic Acid Levels in Patients with Bipolar Disorder. ( Ishioka, M; Kubo, K; Miyazaki, K; Nakagami, T; Shimoda, K; Sugawara, N; Tarakita, N; Yasui-Furukori, N; Yokoyama, S, 2020) |
| "Dose individualization is essential in epilepsy treatment, especially in antiepileptic drugs that present high interindividual variability such as lamotrigine." | 7.96 | Dosing Recommendations Based on Population Pharmacokinetics of Lamotrigine in Mexican Adult Patients With Epilepsy. ( Chávez-Castillo, CE; Medellín-Garibay, SE; Milán-Segovia, RDC; Rodríguez-Leyva, I; Romano-Moreno, S, 2020) |
| "In January 2019, a new plant-derived purified cannabidiol preparation, approved by the US Food and Drug Administration, became commercially available for patients ≥2 years old with Lennox-Gastaut syndrome or Dravet syndrome." | 7.96 | Thrombocytopenia in pediatric patients on concurrent cannabidiol and valproic acid. ( Carlson, M; Dang, LT; Fedak Romanowski, EM; Joshi, SM; Leber, SM; McNamara, NA; Robertson, P; Shellhaas, RA; Smith, GC; Sturza, J; Ziobro, JM, 2020) |
| "To evaluate the changes of epileptiform activity index (EAI) as a measure of the efficacy and tolerability of treatment with valproic acid (VA) in patients with newly-diagnosed generalized and focal epilepsy." | 7.96 | [Dynamics of epileptiform activity, efficacy and tolerability of valproic acid in adults and adolescents with newly-diagnosed epilepsy]. ( Karlov, VA; Kozhokaru, AB; Orlova, AS; Pushkar, TN; Vlasov, PN, 2020) |
| "Due to the narrow therapeutic window of valproic acid (VPA), grievous adverse reactions such as hepatotoxicity, nephrotoxicity may occur in patients with epilepsy for a long time." | 7.96 | Valproic acid concentration and biochemical indexes in epilepsy outpatients during monotherapy or combination therapy. ( Luo, J; Ma, H; Pan, J; Wang, C; Wang, P; Yang, X, 2020) |
| "The aim of this study was to evaluate the effects of valproate (VPA), lamotrigine (LTG), and levetiracetam (LEV) on bone turnover and bone mineral density (BMD) in newly diagnosed adult patients with epilepsy." | 7.96 | Effects of valproate, lamotrigine, and levetiracetam monotherapy on bone health in newly diagnosed adult patients with epilepsy. ( Guo, Y; Huang, Y; Lin, Z; Yu, L, 2020) |
| "Phenobarbital and sodium valproate are broad spectrum and inexpensive antiepileptic drugs that are used to treat convulsive epilepsy." | 7.91 | Efficacy of phenobarbital and sodium valproate in treating convulsive epilepsy in rural northeast China. ( Li, J; Li, N; Lin, W; Yang, D; Zhao, D, 2019) |
| " A 13-year-old girl with genetically confirmed Pitt-Hopkins syndrome with uncontrolled seizures, while on treatment with levetiracetam and valproic acid, was started on perampanel, reaching seizure control." | 7.91 | Perampanel-induced hair curling in a patient with epilepsy associated with Pitt Hopkins syndrome. ( Calle-Lopez, Y; Knight, EP; Kotagal, P, 2019) |
| "The objective of this study was to evaluate the long-term safety, tolerability, and efficacy of cannabidiol in children with epilepsy." | 7.91 | Long-Term Safety, Tolerability, and Efficacy of Cannabidiol in Children with Refractory Epilepsy: Results from an Expanded Access Program in the US. ( Caminha Nunes, E; Cilio, MR; Oldham, MS; Rahdari, S; Sands, TT; Tilton, N, 2019) |
| "The aims of this study were to identify the influencing factors such as gender, age, dose and combinations of other antiepileptic drugs (AEDs), especially in triple combinations on the pharmacokinetic of Lamotrigine (LTG) in epilepsy patients of Northwest Chinese Han population." | 7.91 | The influence of concomitant antiepileptic drugs on lamotrigine serum concentrations in Northwest Chinese Han population with epilepsy. ( Han, X; Huang, J; Lv, J; Ma, L; Nie, X; Peng, L; Wang, J; Xia, L; Zan, X, 2019) |
| "Irritability has been described as a frequent adverse event in patients affected by epilepsy and treated with perampanel (PER), levetiracetam (LEV), and less frequently with valproic acid (VPA)." | 7.91 | Preliminary evidence about irritability in patients with epilepsy treated by perampanel as first add-on therapy compared to levetiracetam and valproic acid. ( Assogna, M; Canevini, MP; Izzi, F; Liguori, C; Mercuri, NB; Placidi, F; Turner, K, 2019) |
| "There is a large inter-individual variation in the efficacy of valproic acid (VPA) against epilepsy." | 7.91 | SCN1A and SCN2A polymorphisms are associated with response to valproic acid in Chinese epilepsy patients. ( Chen, X; Li, H; Lin, C; Luo, J; Shi, L; Wen, Z; Zhang, Z; Zhu, M, 2019) |
| "This study measured the serum carnitine levels in patients with epilepsy and determined the factors contributing to low carnitine levels." | 7.91 | Serum carnitine levels of children with epilepsy: Related factors including valproate. ( Iwayama, H; Kurahashi, H; Numoto, S; Okumura, A, 2019) |
| "Valproic acid (VPA) is used as one of the first-line antiepileptic drugs to control seizure in epilepsy patients." | 7.91 | Correlation of MCT1 and ABCC2 gene polymorphisms with valproic acid resistance in patients with epilepsy on valproic acid monotherapy. ( Chen, J; Chen, Z; Huang, M; Li, H; Qin, J; Ruan, H; Su, Q; Wang, X; Zhou, L; Zhou, S; Zhou, Y, 2019) |
| "The aim of this study is to evaluate if valproate (VPA) and levetiracetam (LEV) as monotherapy are associated with vitamin D deficiency among children with epilepsy." | 7.88 | Vitamin D deficiency in children with epilepsy taking valproate and levetiracetam as monotherapy. ( Aguilera-Albesa, S; Durá-Travé, T; Gallinas-Victoriano, F; Malumbres-Chacón, M; Moreno-Gónzalez, P; Yoldi-Petri, ME, 2018) |
| "To assess the effect of monotherapy with Carbamazepine (CBZ) and Sodium valproate (VPA) on serum 25-OH Vitamin D levels in children with epilepsy compared to controls." | 7.88 | Vitamin D Deficiency in Ambulant Children on Carbamazepine or Sodium Valproate Monotherapy. ( Devadathan, K; Mohammed Kunju, PA; Muthubeevi, S; Pillai, JP; Sasidharan, B; Sreedharan, M; Vasumathy Amma, MA, 2018) |
| "To explore the incidence and independent risk-factors of secondary carnitine deficiency in Chinese children with epilepsy on valproate monotherapy." | 7.88 | Carnitine Deficiency in Chinese Children with Epilepsy on Valproate Monotherapy. ( Hong, J; Qiliang, L; Wenqi, S, 2018) |
| "In the study, the effect of valproic acid on serum free/acylcarnitine levels and left ventricular systolic function in pediatric patients with idiopathic epilepsy receiving valproic acid was investigated." | 7.88 | Evaluation ofserum free carnitine/acylcarnitine levels and left ventricular systolic functions in children with idiopathic epilepsy receiving valproic acid. ( Celik, H; Ince, H; Kulhas Celik, I; Sungur, M; Tasdemir, HA, 2018) |
| "Adults with epilepsy on lamotrigine monotherapy (n = 131) or lamotrigine + valproate treatment (n = 74) were genotyped and steady-state lamotrigine and valproate morning troughs were determined as a part of routine therapeutic drug monitoring." | 7.88 | Interaction between ABCG2 421C>A polymorphism and valproate in their effects on steady-state disposition of lamotrigine in adults with epilepsy. ( Božina, N; Čajić, I; Ganoci, L; Klarica Domjanović, I; Lovrić, M; Petelin-Gadže, Ž; Trkulja, V, 2018) |
| "This study was aimed at identifying genetic and non-genetic risk factors for valproic acid (VPA)-induced hyperammonaemia in Chinese paediatric patients with epilepsy." | 7.88 | Risk Factors for Valproic Acid-induced Hyperammonaemia in Chinese Paediatric Patients with Epilepsy. ( Li, X; Zhang, T; Zhao, L; Zhu, X, 2018) |
| "Evaluation of biochemical derangements related to metabolic syndrome in epileptic patients on treatment with Valproic acid." | 7.88 | Biochemical derangements related to metabolic syndrome in epileptic patients on treatment with valproic acid. ( Bobby, Z; Nisha, Y; Wadwekar, V, 2018) |
| "Valproic acid (VPA) provides a common treatment for both epilepsy and bipolar disorder; however, common cellular mechanisms relating to both disorders have yet to be proposed." | 7.88 | Diacylglycerol kinase (DGKA) regulates the effect of the epilepsy and bipolar disorder treatment valproic acid in ( Kelly, E; Sharma, D; Wilkinson, CJ; Williams, RSB, 2018) |
| "Because the pharmacokinetic evaluation of valproic acid (VPA) based on total drug concentration may be misleading in patients with hypoalbuminemia as a result of saturable protein binding and saturable metabolism, we sought to investigate the usefulness of therapeutic drug monitoring of unbound VPA concentration in a real-world clinical context, with a focus on clinically significant neurologic adverse outcomes." | 7.85 | Clinical Importance of Monitoring Unbound Valproic Acid Concentration in Patients with Hypoalbuminemia. ( Doré, M; Frenette, AJ; San Juan, AE; Williamson, D, 2017) |
| "The aim of the study is to evaluate the association between genetic polymorphisms and valproic acid (VPA) concentration to dose ratio in children with epilepsy on VPA monotherapy." | 7.85 | Genetic polymorphisms and valproic acid plasma concentration in children with epilepsy on valproic acid monotherapy. ( Fang, F; Feng, W; Gao, B; Mei, S; Wu, X; Yang, W; Yu, Y; Zhao, Z; Zhu, L, 2017) |
| "This retrospective longitudinal study included 85 VPA-treated and 93 carbamazepine (CBZ)-treated (as a reference) young patients with epilepsy." | 7.83 | Cytochrome P450 2C19 polymorphisms and valproic acid-induced weight gain. ( Ishitsu, T; Kajiwara, A; Nakagawa, K; Noai, M; Oniki, K; Saruwatari, J; Soraoka, H; Tanamachi, Y, 2016) |
| "Valproic acid (VPA) is widely used in the treatment of children with epilepsy." | 7.83 | Effects of UGT2B7 Genetic Polymorphisms on Serum Concentrations of Valproic Acid in Chinese Children With Epilepsy Comedicated With Lamotrigine. ( Dong, Y; Guo, Y; Liang, M; Meng, H; Qiu, F; Wang, Q; Yun, W; Zhao, L, 2016) |
| "To confirm the hypothesis suggested above, a combined analysis of survival association of antiepileptic drug use at the start of chemoradiotherapy with temozolomide was performed in the pooled patient cohort (n = 1,869) of four contemporary randomized clinical trials in newly diagnosed glioblastoma: AVAGlio (Avastin in Glioblastoma; NCT00943826), CENTRIC (Cilengitide, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma and Methylated Gene Promoter Status; NCT00689221), CORE (Cilengitide, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma and Unmethylated Gene Promoter Status; NCT00813943), and Radiation Therapy Oncology Group 0825 (NCT00884741)." | 7.83 | Does Valproic Acid or Levetiracetam Improve Survival in Glioblastoma? A Pooled Analysis of Prospective Clinical Trials in Newly Diagnosed Glioblastoma. ( Chinot, O; Cloughesy, T; Gilbert, MR; Gorlia, T; Happold, C; Hegi, M; Mehta, MP; Nabors, LB; Perry, JR; Pugh, SL; Reardon, DA; Roth, P; Stupp, R; Weller, M; Wick, W, 2016) |
| "To identify the factors influencing topiramate pharmacokinetics (PK) in a large population of adult patients with epilepsy using population PK analysis." | 7.83 | Factors influencing topiramate clearance in adult patients with epilepsy: A population pharmacokinetic analysis. ( Bae, EK; Jang, IJ; Kim, TJ; Lee, J; Lee, KJ; Lee, SK; Moon, J; Shin, D; Shin, JW; Shin, YW, 2016) |
| "Studies of the effect of oxcarbazepine (OXC) on body growth of children with epilepsy are rare and their results are controversial." | 7.83 | Weight gain in children on oxcarbazepine monotherapy. ( Attilakos, A; Garoufi, A; Katsarou, E; Koemtzidou, E; Kossiva, L; Soldatou, A; Tsentidis, C; Vartzelis, G, 2016) |
| "Although it has been reported that some antiepileptic drugs have inducing or inhibiting effects on lamotrigine (LTG) clearance, whether they have the same effects in Asian epilepsy patients as in those in other countries has not been clarified, especially in children." | 7.83 | The effects of co-medications on lamotrigine clearance in Japanese children with epilepsy. ( Abe, S; Azuma, Y; Ishihara, N; Ito, Y; Itomi, K; Kidokoro, H; Kojima, S; Kurahashi, H; Kurahashi, N; Maruyama, K; Natsume, J; Negoro, T; Okumura, A; Suzuki, M; Takeuchi, T; Tsuji, T; Watanabe, K; Yamada, K; Yamamoto, H, 2016) |
| "The aim of this study was to compare the risk of metabolic syndrome (MS) and evaluate related factors for MS among people with epilepsy treated with valproate (VPA) or carbamazepine (CBZ)." | 7.83 | Metabolic syndrome and anticonvulsants: A comparative study of valproic acid and carbamazepine. ( Haldre, S; Kõks, S; Rakitin, A, 2016) |
| "To identify potential risk factors for the development of subclinical hypothyroidism following long-term valproic acid monotherapy in children with epilepsy." | 7.83 | Duration of valproic acid monotherapy correlates with subclinical thyroid dysfunction in children with epilepsy. ( Bogićević, D; Ilić, V; Ješić, M; Kovačević, M; Kovačević, SV; Miljković, B; Prostran, M, 2016) |
| "Based on data from the EURAP observational International registry of antiepileptic drugs (AEDs) and pregnancy, we assessed changes in seizure control and subsequent AED changes in women who underwent attempts to withdraw valproic acid (VPA) during the first trimester of pregnancy." | 7.83 | Withdrawal of valproic acid treatment during pregnancy and seizure outcome: Observations from EURAP. ( Battino, D; Bonizzoni, E; Craig, J; Lindhout, D; Perucca, E; Sabers, A; Thomas, SV; Tomson, T; Vajda, F, 2016) |
| " Here, we suggest that triggering limbic seizures with low doses of PTZ in pilocarpine-treated marmosets might provide a more effective basis for the development of AED." | 7.83 | Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. ( Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM, 2016) |
| "Valproic acid (VPA) is a widely used antiepileptic drug with acceptable safety and efficacy in treating pediatric patients with various kinds of seizures." | 7.83 | Effects of UGT1A6 and GABRA1 on Standardized Valproic Acid Plasma Concentrations and Treatment Effect in Children With Epilepsy in China. ( Fang, F; Feng, W; Gao, B; Mei, S; Wu, X; Yang, W; Yu, Y; Zhao, Z; Zhu, L, 2016) |
| "Lamotrigine (LTG) is a widely used antiepileptic-drug (AED) for the treatment of epilepsy." | 7.81 | Effect of comedication on lamotrigine clearance in Korean epilepsy patients. ( Hong, SB; Joo, EY; Kim, HJ; Kim, TE; Lee, SY; Seo, DW, 2015) |
| "Stiripentol is an antiepileptic drug (AED) approved by the European Medicines Agency for the treatment of Dravet Syndrome (DS) as adjunct treatment with valproate and clobazam." | 7.81 | Extending the use of stiripentol to other epileptic syndromes: a case of PCDH19-related epilepsy. ( Specchio, N; Trivisano, M; Vigevano, F, 2015) |
| "Carnitine deficiency is relatively common in epilepsy; risk factors reportedly include combination antiepileptic drug (AED) therapy with valproic acid (VPA), young age, intellectual disability, diet and enteral or parenteral feeding." | 7.81 | Carnitine deficiency: Risk factors and incidence in children with epilepsy. ( Fukuda, M; Ishii, E; Iwano, S; Kawabe, M; Kikuchi, C; Kuwabara, K; Morimoto, T; Suzuki, Y; Takehara, M; Wakamoto, H, 2015) |
| "Weight gain is the most frequent adverse effect of valproic acid (VPA) treatment, resulting in poor compliance and many endocrine disturbances." | 7.81 | Association of LEPR and ANKK1 Gene Polymorphisms with Weight Gain in Epilepsy Patients Receiving Valproic Acid. ( Chen, X; Chen, Z; Hou, X; Huang, M; Li, H; Li, J; Ni, G; Su, Q; Wang, X; Xie, W; Xin, S; Zhou, L; Zhou, Y, 2015) |
| "To prospectively evaluate the long-term impact of valproate (VPA) versus carbamazepine (CBZ) on anthropometric, hormonal, and metabolic parameters in young male patients treated for epilepsy." | 7.81 | Endocrine Effects of Valproate versus Carbamazepine in Males with Epilepsy: A Prospective Study. ( de Vries, L; Goldberg-Stern, H; Itzhaki, T; Landau, Z, 2015) |
| "Lamotrigine (LTG) is widely used in the treatment of children with epilepsy." | 7.81 | Effects of UGT1A4 genetic polymorphisms on serum lamotrigine concentrations in Chinese children with epilepsy. ( Dong, Y; Guo, Y; Liang, M; Qiu, F; Wang, Q; Yun, W; Zhao, L, 2015) |
| "The study was conducted on children aged 8-16 years who were undergoing valproic acid monotherapy for epilepsy." | 7.81 | An Evaluation of Peripapillary Retinal Nerve Fiber Layer Thickness in Children With Epilepsy Receiving Treatment of Valproic Acid. ( Akçam, M; Dereci, S; Koca, T; Türkyilmaz, K, 2015) |
| "The aim of this study was to investigate the distribution and frequency of genetic polymorphisms in uridine diphosphate glucuronosyltransferase-2B7 (UGT2B7) in epilepsy patients and to evaluate the effect of these on the metabolism of valproic acid (VPA)." | 7.81 | The influence of UGT2B7 genotype on valproic acid pharmacokinetics in Chinese epilepsy patients. ( Huang, HW; Lin, H; Luo, YH; Peng, ZK; Sun, YX; Tang, FQ; Wang, HM; Zhuo, WY, 2015) |
| "Valproic acid (VPA) is a useful antiepileptic drug for controlling different types of epilepsy." | 7.81 | [The prevalence of obesity and metabolic syndrome in paediatric patients with epilepsy treated in monotherapy with valproic acid]. ( Carmona-Vazquez, CR; Diaz-Garcia, L; Greenawalt, SR; Pena-Landin, DM; Ruiz-Garcia, M, 2015) |
| "To examine the effects of cytochrome P450 3A4 (CYP3A4), cytochrome P450 3A5 (CYP3A5) and ATP-binding cassette sub-family B member 1 (ABCB1) genetic polymorphisms on carbamazepine (CBZ) plasma concentrations in Chinese patients with epilepsy using CBZ as monotherapy and bitherapy with phenytoin (PHT), phenobarbital (PB), or valproic acid (VPA)." | 7.81 | Effects of CYP3A4/5 and ABCB1 genetic polymorphisms on carbamazepine metabolism and transport in Chinese patients with epilepsy treated with carbamazepine in monotherapy and bitherapy. ( Liu, DQ; Ma, HY; Sheng, YH; Wang, C; Wang, P; Yin, T; Zhou, BT, 2015) |
| "Valproic acid (VPA), which is widely used to treat epilepsy, migraine, and bipolar disorder, can causes severe hyperammonemia." | 7.81 | Influence of glutamine synthetase gene polymorphisms on the development of hyperammonemia during valproic acid-based therapy. ( Hirai, K; Imai, K; Inoue, K; Inoue, Y; Itoh, K; Suzuki, E; Takahashi, T; Takahashi, Y; Tsuji, D; Yamamoto, Y, 2015) |
| "Valproic acid (VPA) is widely used to treat various types of epilepsy." | 7.80 | Influence of uridine diphosphate glucuronosyltransferase 2B7 -161C>T polymorphism on the concentration of valproic acid in pediatric epilepsy patients. ( Hayashi, H; Imai, K; Inoue, K; Inoue, Y; Itoh, K; Koyama, S; Suzuki, E; Takahashi, T; Takahashi, Y; Tsuji, D; Yamamoto, Y; Yazawa, R, 2014) |
| "A 12-year-old patient with refractory epilepsy syndrome presented with phenytoin toxicity, following a concomitant treatment with phenytoin, valproic acid, and lamotrigine." | 7.80 | Drug interaction between phenytoin and valproic acid in a child with refractory epilepsy: a case report. ( Carnevale, RC; Carvalho, IV; de Fátima Lopes Ambrósio, R; de Queiroz, RA; dos Reis, MC; Mazzola, PG; Moriel, P; Visacri, MB, 2014) |
| "Lacosamide (LCM), a new antiepileptic drug (AED) approved as adjunctive therapy for the treatment of patients with partial-onset seizures, has limited pharmacokinetic and drug interaction data." | 7.80 | Lacosamide serum concentrations in adult patients with epilepsy: the influence of gender, age, dose, and concomitant antiepileptic drugs. ( Duncan, JS; Markoula, S; Patsalos, PN; Ratnaraj, N; Sander, JW; Teotonio, R, 2014) |
| "The aims of this study were to characterize a lamotrigine-resistant kindled model of epilepsy in mice, to study the anticonvulsant effect of carbamazepine (CBZ) and valproic acid (VPA), and to probe into the mechanism for resistance." | 7.80 | Characterization of a lamotrigine-resistant kindled model of epilepsy in mice: evaluation of drug resistance mechanisms. ( Mehndiratta, M; Pillai, KK; Singh, E, 2014) |
| "Valproic acid, a branched short-chain fatty acid, has numerous action mechanisms which turn it into a broad spectrum anticonvulsant drug and make its use possible in some other pathologies such as bipolar disorder." | 7.80 | Hyperammonemia associated with valproic acid concentrations. ( Alvariza, S; Fagiolino, P; Guevara, N; Ibarra, M; Magallanes, L; Maldonado, C; Olano, I; Olmos, I; Vázquez, M, 2014) |
| "Valproic acid, which is widely used to treat various types of epilepsy, may cause severe hyperammonemia." | 7.80 | 4217C>A polymorphism in carbamoyl-phosphate synthase 1 gene may not associate with hyperammonemia development during valproic acid-based therapy. ( Hayashi, H; Imai, K; Inoue, K; Inoue, Y; Itoh, K; Miyakawa, K; Suzuki, E; Takahashi, T; Takahashi, Y; Tsuji, D; Yamamoto, Y; Yazawa, R, 2014) |
| "To investigate biochemical cardiovascular risk factors and vascular endothelial function and structure in children with epilepsy on antiepileptic drugs (AEDs), particularly sodium valproate (VPA) and carbamazepine (CBZ)." | 7.80 | Vascular function and risk factors in children with epilepsy: associations with sodium valproate and carbamazepine. ( Keenan, N; Sadlier, LG; Wiltshire, E, 2014) |
| "Hyperammonemia has been reported to be associated with patients who receive valproic acid (VPA) therapy." | 7.80 | Risk factors of hyperammonemia in patients with epilepsy under valproic acid therapy. ( Chang, CC; Chang, WN; Chen, NC; Chuang, YC; Huang, CR; Lin, CH; Lu, CH; Lu, YT; Tseng, YL, 2014) |
| "To facilitate therapeutic monitoring of antiepileptic drugs (AEDs) by healthcare professionals for patients with epilepsy (PWE), we applied a GC-MS assay to measure three AEDs: carbamazepine (CBZ), phenytoin (PHT) and valproic acid (VPA) levels concurrently in one dried blood spot (DBS), and validated the DBS-measured levels to their plasma levels." | 7.80 | Clinical validation and implications of dried blood spot sampling of carbamazepine, valproic acid and phenytoin in patients with epilepsy. ( Ho, PC; Kong, ST; Kumar, PK; Lee, WB; Lim, SH; Ng, YL; Wang, HY; Wong, PS, 2014) |
| "The combination of lamotrigine and valproate/divalproex sodium has been shown to be effective in the treatment of refractory epilepsy." | 7.79 | Valproate and lamotrigine in pediatric patients with refractory epilepsy: after the first year. ( Thome-Souza, S; Valente, KD, 2013) |
| "Our findings suggest that the UGT1A6 (552A>C) genetic polymorphism plays a significant role in the steady state concentration of valproic acid, and it thereby has an impact on the toxicity of the valproic acid used in the patients with epilepsy." | 7.79 | The effect of uridine diphosphate glucuronosyltransferase (UGT)1A6 genetic polymorphism on valproic acid pharmacokinetics in Indian patients with epilepsy: a pharmacogenetic approach. ( Arumugam, K; Behari, M; Jain, DC; Mallayasamy, SR; Munisamy, M; Raghavan, S; Rajakannan, T; Ramanujam, B; Subbiah, V; Tripathi, M, 2013) |
| " We investigated the effects of valproic acid and topiramate on the levels of insulin, c-peptide and adipocytokines in pre-pubertal patients with idiopathic partial and generalized epilepsy." | 7.79 | The effects of topiramate and valproate therapy on insulin, c-peptide, leptin, neuropeptide Y, adiponectin, visfatin, and resistin levels in children with epilepsy. ( Aksoy, A; Aliyazicioglu, R; Deger, O; Fazlioglu, K; Karaguzel, G; Sonmez, FM; Zaman, D, 2013) |
| " (MQ) in maximal electroshock (MES) and pentylenetetrazole (PTZ) induced rat models of epilepsy." | 7.79 | Evaluation of anti-epileptic property of Marsilea quadrifolia Linn. in maximal electroshock and pentylenetetrazole-induced rat models of epilepsy. ( Avinash, H; Chandrashekar, BR; Mukunda, N; Naduvil Narayanan, S; Nayak, BS; Raghavendra Rao, K; Sadhana, N; Satish Kumar, MC; Snehunsu, A; Vijay Kapgal, K, 2013) |
| "We studied 107 patients with epilepsy who received monotherapy with valproic acid drugs (58) and carbamazepine (49)." | 7.79 | [Season fluctuations of carbamazepine and valproate concentration in patients with epilepsy]. ( Avakian, GG; Avakian, GN; Bogomazova, MA; Delger, AB; Khromykh, EA; Lagutin, IuV; Oleĭnikova, OM, 2013) |
| "The participants included 53 epilepsy patients who received either valproic acid (VPA, n=26) or oxcarbazepine (OXC, n=27)." | 7.79 | Assessment of atherosclerosis risk due to the homocysteine-asymmetric dimethylarginine-nitric oxide cascade in children taking antiepileptic drugs. ( Arga, M; Arhan, E; Biberoglu, G; Cansu, A; Emeksiz, HC; Gulbahar, O; Hasanoglu, A; Serdaroglu, A, 2013) |
| "Valproic acid (VPA) is a well-established anticonvulsant drug that has been increasingly used in the treatment of many forms of generalized epilepsy." | 7.78 | Simultaneous determination of valproic acid and 2-propyl-4-pentenoic acid for the prediction of clinical adverse effects in Chinese patients with epilepsy. ( Chen, SD; Chen, ZJ; Fang, ZY; Huang, M; Li, JL; Shu, WY; Wang, HS; Wang, XD; Zhang, Y; Zhou, JQ; Zhou, LM, 2012) |
| "The aim of this study was to investigate the genetic polymorphisms of UGT1A3, UGT1A6, and UGT2B7 in Chinese epilepsy patients and their potential influence on the pharmacokinetics of valproic acid (VPA)." | 7.78 | Influence of UDP-glucuronosyltransferase polymorphisms on valproic acid pharmacokinetics in Chinese epilepsy patients. ( Chu, XM; Hao, HP; Wang, GJ; Zhang, LF; Zhang, SN; Zhou, JH, 2012) |
| "Hyperammonemia is one of the side effects of treatment with valproic acid (VPA), but the risk factors and mechanisms involved remain obscure." | 7.78 | Risk factors for hyperammonemia associated with valproic acid therapy in adult epilepsy patients. ( Inoue, K; Inoue, Y; Itoh, K; Kagawa, Y; Mishima, N; Suzuki, E; Takahashi, Y; Yamamoto, Y, 2012) |
| "The aim of this study was to evaluate the incidence of thyroid dysfunction during valproic acid (VPA) therapy in children and adolescents with epilepsy." | 7.78 | Subclinical hypothyroidism during valproic acid therapy in children and adolescents with epilepsy. ( Chae, JH; Chung, HR; Hwang, H; Hwang, YS; Kim, H; Kim, KJ; Kim, SH; Lim, BC, 2012) |
| "We report 2 children with a history of epilepsy in whom valproic acid (VPA) withdrawal was identified as a potential cause of hallucinations." | 7.78 | Hallucinations after withdrawal of valproic acid. ( Braun, KP; de Graeff-Meeder, ER; de Laat, SA; Hillegers, MH; Jansen, FE, 2012) |
| "We examined the influence of age and type of concomitant antiepileptic drugs (AEDs) on the pharmacokinetics of rufinamide (RUF) as well as its efficacy and safety in 51 children with refractory epilepsy." | 7.78 | Rufinamide in children with refractory epilepsy: pharmacokinetics, efficacy, and safety. ( Dahlin, MG; Ohman, I, 2012) |
| "Valproic acid (VPA) is one of the most commonly prescribed drugs for the treatment of epilepsy." | 7.78 | Effects of UGT1A6, UGT2B7, and CYP2C9 genotypes on plasma concentrations of valproic acid in Chinese children with epilepsy. ( Guo, Y; He, X; Hu, C; Qiu, F; Zhao, L, 2012) |
| "An open pilot study to evaluate the effect of pregabalin (PGB) as add-on therapy on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy (BTRE)." | 7.78 | Effect of pregabalin add-on treatment on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy: a pilot study. ( Carapella, CM; Dinapoli, L; Fabi, A; Maschio, M; Pace, A; Pompili, A; Sperati, F; Vidiri, A, 2012) |
| "Weight gain is a well-known unwanted effect of valproic acid (VPA) therapy." | 7.77 | Circulating levels of allopregnanolone, a neuroactive steroid, and leptin during treatment with valproic acid in children with epilepsy. ( Balestri, P; Barlocco, EG; Casarosa, E; Grosso, S; Luisi, S; Matera, M; Mostardini, R; Petraglia, F, 2011) |
| "Patients treated with valproic acid (VPA) present a high incidence of non-alcoholic fatty liver disease (NAFLD) (around 61%)." | 7.77 | A preliminary investigation on the possible association between diminished copper availability and non-alcoholic fatty liver disease in epileptic patients treated with valproic acid. ( Lampon, N; Tutor, JC, 2011) |
| "This study aims to investigate the alteration of iron homeostasis and oxidative stress status in epilepsy patients treated with valproic acid (VPA) monotherapy." | 7.77 | Increase in non-transferrin bound iron and the oxidative stress status in epilepsy patients treated using valproic acid monotherapy. ( Atroshi, F; Fucharoen, S; Kaipainen, P; Kaski, M; Ounjaijean, S; Partinen, M; Plonka-Poltorak, E; Srichairatanakool, S; Westermarck, T, 2011) |
| "Lamotrigine (LTG) which has a widespread use in epilepsy treatment as an antiepileptic agent is metabolized by UDP-glucuronosyl transferase (UGT) enzymes." | 7.77 | The relationship between UGT1A4 polymorphism and serum concentration of lamotrigine in patients with epilepsy. ( Aker, RG; Goren, MZ; Gulcebi, MI; Onat, FY; Ozkara, C; Ozkaynakcı, A, 2011) |
| "The aim of this study was to establish the population protein binding parameters of valproic acid (VPA) in patients with epilepsy receiving VPA monotherapy and those receiving VPA combined with other antiepileptic drugs." | 7.77 | No effect of co-administered antiepileptic drugs on in-vivo protein binding parameters of valproic acid in patients with epilepsy. ( Abe, T; Itoh, H; Nishimura, F; Sato, Y; Suzuki, Y; Takeyama, M, 2011) |
| "We investigated the effect of lamotrigine (LTG) add-on therapy in 50 patients with childhood-onset refractory epilepsy (25 males and 25 females): 15 with localization-related epilepsy, 33 with generalized epilepsy, and 2 with undetermined epilepsy." | 7.77 | [Lamotrigine add-on therapy for childhood-onset refractory epilepsy: comparison of the efficacy between 3 months and 6 months after initiation]. ( Endoh, F; Kobayashi, K; Ohtsuka, Y; Watanabe, K; Yoshinaga, H, 2011) |
| " Patients with clinically stable partial or generalized epilepsy, already receiving lamotrigine or valproic acid on monotherapy, were assessed in two visits: baseline and at 6 months." | 7.76 | Quality of life and treatment satisfaction in Spanish epilepsy patients on monotherapy with lamotrigine or valproic acid. ( Barriga, J; Cobaleda, S; Codina, M; Lahuerta, J; Morales, MD; Viteri, C, 2010) |
| "Lamotrigine (LTG) is increasingly being prescribed in pregnancy for women with epilepsy in place of valproate (VPA), because of the teratogenic risks associated with the latter." | 7.76 | Is lamotrigine a significant human teratogen? Observations from the Australian Pregnancy Register. ( Eadie, MJ; Graham, JE; Hitchcock, AA; Lander, CM; O'Brien, TJ; Vajda, FJ, 2010) |
| " In utero, exposure to valproic acid (VPA) and phenytoin (PH) may cause congenital malformations and also withdrawal symptoms such as irritability, jitteriness and symptoms of hypoglycemia." | 7.76 | Neonatal episodic hypoglycemia: a finding of valproic acid withdrawal. ( Akçakuş, M; Akın, MA; Çoban, D; Güneş, T; Kurtoğlu, S, 2010) |
| "We evaluated the serum leptin and insulin as predictors of weight gain in children receiving long-term treatment with valproate (VPA), carbamazepine (CBZ), lamotrigine (LTG)." | 7.75 | States of serum leptin and insulin in children with epilepsy: risk predictors of weight gain. ( Fida, NM; Hamed, EA; Hamed, SA, 2009) |
| "Valproic acid-associated weight gain may occur in young children." | 7.75 | Body mass index and serum lipid changes during treatment with valproic acid in children with epilepsy. ( Balestri, P; Grosso, S; Mostardini, R; Piccini, B, 2009) |
| "The long-term effects of valproic acid (VPA) on reproductive endocrine functions in women with epilepsy (WWE) were studied." | 7.75 | Long-term effects of valproic acid on reproductive endocrine functions in Turkish women with epilepsy. ( Dogan, EA; Genc, BO; Genc, E; Gorkemli, H; Ozdemir, S, 2009) |
| "The aim of this study is to evaluate the erythrocyte lipid peroxidation and antioxidant enzyme levels in patients with newly diagnosed idiopathic epilepsy before treatment and in patients treated with valproic acid for idiopathic epilepsy." | 7.75 | Effects of epilepsy and valproic acid on oxidant status in children with idiopathic epilepsy. ( Dirik, E; Kuralay, F; Kurul, SH; Seçkin, E; Yiş, U, 2009) |
| " This retrospective study of children with epilepsy, aged <12 years at enrollment, examined weight gain associated with valproic acid or carbamazepine monotherapy." | 7.74 | Lack of valproic acid-associated weight gain in prepubertal children. ( Baumann, RJ; Espinosa, PS; Mendiondo, MS; Robertson, WC; Salazar, JC; Yu, L, 2008) |
| "To determine the influence of valproate (VPA) treatment on acylcarnitines in children with epilepsy." | 7.74 | Effects of valproate on acylcarnitines in children with epilepsy using ESI-MS/MS. ( Gerstner, T; Koenig, SA; Kohlmueller, D; Longin, E; Mehlem, P; Schulze, A; Teich, M; Treiss, I; Werner, T, 2007) |
| "Ecto-nucleotidases, one of the main mechanisms involved in the control of adenosine levels in the synaptic cleft, have shown increased activities after the pilocarpine model of epilepsy." | 7.74 | Antiepileptic drugs prevent changes induced by pilocarpine model of epilepsy in brain ecto-nucleotidases. ( Bogo, MR; Bonan, CD; Bruno, AN; Cognato, Gde P; da Silva, RS; Sarkis, JJ, 2007) |
| "Hypospadias is one of the most frequently occurring genital anomalies described in infants prenatally exposed to valproic acid (VA)." | 7.74 | Risk of hypospadias in newborn infants exposed to valproic acid during the first trimester of pregnancy: a case-control study in Spain. ( Fernández, P; Martínez-Frías, ML; Mejías, C; Prieto-Merino, D; Rodríguez-Pinilla, E, 2008) |
| "The aim of our study was to investigate whether a correlation exists between steady-state serum concentration of valproic acid and quality of life in adolescent patients with epilepsy." | 7.74 | Inverse correlation of valproic acid serum concentrations and quality of life in adolescents with epilepsy. ( Jakovljevic, MB; Jankovic, SM; Jankovic, SV; Todorovic, N, 2008) |
| " The combination of AGLD (5 mg/kg) with phenobarbital (PB, applied at its subeffective dose of 15 mg/kg) significantly shortened motor seizure and afterdischarge duration in amygdala-kindled seizures." | 7.73 | Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats. ( Borowicz, KK; Czuczwar, SJ, 2005) |
| "To report a probable interaction between meropenem and valproic acid that resulted in the development of epileptic seizures." | 7.73 | Acute seizures due to a probable interaction between valproic acid and meropenem. ( Borrás-Blasco, J; Coves-Orts, FJ; Murcia-López, A; Navarro-Ruiz, A; Palacios-Ortega, F, 2005) |
| " However, he was found to have hyperammonemia within 2 weeks after the addition of low-dose topiramate to valproate." | 7.73 | Topiramate-valproate-induced hyperammonemic encephalopathy syndrome: case report. ( Cheung, E; Fung, CW; Wong, V, 2005) |
| "This study evaluated the effect of the addition of zonisamide on valproic acid (valproate sodium) pharmacokinetics under steady-state conditions in patients with epilepsy." | 7.73 | Lack of pharmacokinetic interactions between steady-state zonisamide and valproic acid in patients with epilepsy. ( Brodie, M; Grundy, JS; Levy, RH; Ragueneau-Majlessi, I; Shah, J; Smith, D, 2005) |
| "To evaluate whether the administration of lamotrigine (LTG) or valproate (VPA) changes concentrations of plasma total homocysteine (tHcy), plasma and red-cell folate and plasma Vitamin B-12, we measured these indices in a total of 20 patients with epilepsy before and after a 32-week period of monotherapy of LTG or VPA." | 7.73 | Blood homocysteine, folate and vitamin B-12 concentrations in patients with epilepsy receiving lamotrigine or sodium valproate for initial monotherapy. ( Gidal, BE; Hammer, A; Tamura, T; Vuong, A, 2005) |
| "Valproic acid has been widely used for the treatment of epilepsy." | 7.73 | [Hyperammonemia secondary to the use of valproic acid: case report]. ( Fernandes, RM; Funayama, CA; Turcato, Mde F; Wichert-Ana, L, 2005) |
| "The aim of the study was to obtain pharmacokinetic data for carbamazepine (CBZ) and its fractions not bound with proteins in bitherapy with lamotrigine (LTG), topiramate (TPM), vigabatrin (VGB) or valproic acid (VPA) in children and adolescents treated for epilepsy." | 7.73 | Pharmacokinetic interactions of carbamazepine with some antiepileptic drugs during epilepsy treatment in children and adolescents. ( Steinborn, B, 2005) |
| "Authors presented the data on the efficacy and tolerability of the new anticonvulsant drug topiramate (topamax) in the treatment of 110 children aged from 6 months to 16 years with pharmacoresistant types of epilepsy including 42 patients with tuberous sclerosis." | 7.73 | [The efficacy of topiramate (topamax) in the treatment of resistant epilepsy in children]. ( Belousova, ED; Dorofeeva, MIu; Ermakov, AIu, 2005) |
| ") continuous valproic acid (VPA) infusion, as compared with acute injections in the kindling epilepsy model." | 7.73 | Effect of intracerebroventricular continuous infusion of valproic acid versus single i.p. and i.c.v. injections in the amygdala kindling epilepsy model. ( Alós, M; Barcia, JA; Durán, C; Hernández, ME; Ortiz, P; Serralta, A, 2006) |
| " The mother had been treated with valproic acid (1800mg per day) and lamotrigine (100mg per day) throughout pregnancy." | 7.72 | Valproic acid and lamotrigine treatment during pregnancy. The risk of chromosomal abnormality. ( Cogulu, O; Gunduz, C; Kultursay, N; Ozkinay, F; Yilmaz, D, 2003) |
| "This open-label, cross-sectional study compared (1) endocrine and lipid measures during the early follicular phase of the menstrual cycle; (2) prevalence of menstrual disorders (from patient diaries recorded over three cycles); and (3) body weight of women with epilepsy on lamotrigine monotherapy (n=119) with those on valproate monotherapy (n=103) for <5 years." | 7.72 | Higher androgens and weight gain with valproate compared with lamotrigine for epilepsy. ( Ayala, R; Dam, M; Gomez, G; Isojärvi, J; Messenheimer, J; Morrell, MJ; O'Neill, F; Taylor, AE; Tennis, P, 2003) |
| "A 5-year-old female developed alteration of consciousness during 3 days of long-term treatment with valproic acid for localization-related epilepsy." | 7.72 | Reversible altered consciousness with brain atrophy caused by valproic acid. ( Eguchi, M; Imataka, G; Nakagawa, E; Ota, T; Yamanouchi, H, 2003) |
| "Two months-old girl with psychomotor retardation had aminophylline-resistant apnea attacks and was investigated by video-EEG recording." | 7.72 | [A case of infantile epileptic apnea with congenital brain anomaly]. ( Hamano, K; Iwasaki, N; Matsui, A; Ohto, T; Takahashi, M; Tanaka, R, 2003) |
| "A 70-year-old woman under anticonvulsive therapy with carbamazepine and valproate was diagnosed as polymyalgia rheumatica." | 7.72 | [A case of polymyalgia rheumatica with improved steroid-responsibility after discontinuing carbamazepine]. ( Katada, S; Kobayashi, H; Sato, A; Sato, M, 2004) |
| "To investigate the possible role of valproic acid therapy in the development of the weight gain and hyperinsulinemia of epileptic patients." | 7.72 | [Insulin resistance in epileptic patients during treatment of valproic acid]. ( Bao, YY; Chen, Z; Ding, MP; Liu, ZR; Xu, LL, 2004) |
| "In the past 6 years, 11 children on valproic acid have developed pancreatitis in our children's hospital." | 7.72 | Valproic acid-induced pancreatitis in childhood epilepsy: case series and review. ( Berg, M; Breault, R; Sinclair, DB, 2004) |
| "In order to investigate the possible role of valproic acid therapy in the development of obesity, hyperinsulinism and polycystic ovaries (PCOs), we have studied metabolic parameters and ovarian morphology in epileptic women." | 7.71 | Polycystic ovaries, obesity and insulin resistance in women with epilepsy. A comparative study of carbamazepine and valproic acid in 105 women. ( Abraham, I; Alge, A; Bauer, G; Haslinger, M; Lechleitner, M; Luef, G; Seppi, K; Trinka, E; Unterberger, I; Windisch, J, 2002) |
| "A 15-year-old boy with epilepsy and cerebral calcifications, treated with valproic acid, ethyl phenylbarbiturate and ethosuximide, was referred for drug induced systemic lupus erythematosus." | 7.71 | Latent coeliac disease in a child with epilepsy, cerebral calcifications, drug-induced systemic lupus erythematosus and intestinal folic acid malabsorption associated with impairment of folic acid transport across the blood-brain barrier. ( Calvani, M; Guaitolini, C; Paolone, G; Parisi, G; Parisi, P, 2001) |
| "It is not known whether polytherapy with carbamazepine (CBZ) and valproate (VPA) increases the risk of thrombocytopenia." | 7.71 | Severe, isolated thrombocytopenia under polytherapy with carbamazepine and valproate. ( Finsterer, J; Hess, B; Pelzl, G, 2001) |
| " This study aimed to evaluate thyroid function in men taking carbamazepine (CBZ), oxcarbazepine (OCBZ), or valproate (VPA) for epilepsy." | 7.71 | Thyroid function in men taking carbamazepine, oxcarbazepine, or valproate for epilepsy. ( Isojärvi, JI; Kotila, M; Myllylä, VV; Pakarinen, AJ; Rättyä, J; Turkka, J, 2001) |
| "To determine whether long-term treatment with valproate (VPA) and/or lamotrigine (LTG) in children with epilepsy is associated with altered growth and/or bone metabolism." | 7.71 | Long-term valproate and lamotrigine treatment may be a marker for reduced growth and bone mass in children with epilepsy. ( Atkinson, SA; Guo, CY; Ronen, GM, 2001) |
| "Dynamics of carbamazepine and valproic acid concentrations in the middle of follicular and lutein menstrual cycle phases has been studied in women with epilepsy, aged 21-30 years." | 7.71 | [Pharmacokinetic aspects of carbamazepine and valproic acid using in reproductive-age women with epilepsy]. ( Karlov, VA; Sokolov, AV; Tishchenkova, IF; Vlasov, PN, 2002) |
| " Leptin is considered a signaling factor regulating body weight and energy metabolism." | 7.71 | Serum insulin and leptin levels in valproate-associated obesity. ( Isojärvi, JI; Knip, M; Kotila, M; Pakarinen, A; Pylvänen, V; Turkka, J, 2002) |
| "Valproic acid is effective for treatment of many types of epilepsy, but its use in epileptic patients can be associated with an increase in body weight that could interfere with treatment compliance." | 7.71 | Insulin resistance in epileptic girls who gain weight after therapy with valproic acid. ( Basciani, F; Chiarelli, F; De Simone, M; Morgese, G; Trotta, D; Verrotti, A, 2002) |
| "In November 1996, a panel of pediatric neurologists met to update the consensus statement issued in 1989 by a panel of neurologists and metabolic experts on L-carnitine supplementation in childhood epilepsy." | 7.70 | L-carnitine supplementation in childhood epilepsy: current perspectives. ( Bohan, TP; Coulter, DL; De Vivo, DC; Dreifuss, FE; Greenwood, RS; Nordli, DR; Shields, WD; Stafstrom, CE; Tein, I, 1998) |
| "Forty girls taking valproate (VPA), 19 girls taking carbamazepine (CBZ), and 18 girls taking oxcarbazepine (OXC) for epilepsy and 49 healthy control girls participated in the study, which included a cross-sectional clinical examination when the girls were 8 to 18 years old and a longitudinal growth analysis from the age of 1 year." | 7.70 | The effects of valproate, carbamazepine, and oxcarbazepine on growth and sexual maturation in girls with epilepsy. ( Isojärvi, JI; Knip, M; Lanning, P; Rättyä, J; Vainionpää, L, 1999) |
| "Neural tube defects (NTDs) are the most common of the major anomalies associated with in utero exposure to valproic acid." | 7.70 | Safe use of valproic acid during pregnancy. ( Kennedy, D; Koren, G, 1999) |
| "We previously encountered a patient with epilepsy who exhibited rapid elimination of sustained-release valproic acid (VPA) administered at the dose of 2." | 7.70 | Valproic acid elimination rate and urinary excretion of its glucuronide conjugate in patients with epilepsy. ( Akiyama, T; Hayashi, T; Hirozane, K; Kamiya, A; Katayama, H; Kimoto, H; Watanabe, M; Yoshida, H; Yoshitomi, H, 1999) |
| "We determined serum levels of triiodothyronine (T3), thyroxine (T4), free thyroxine (FT4), thyroxine-binding globulin (TBG), and thyroid-stimulating hormone (TSH) in 148 healthy children and 141 children with epilepsy who had been receiving CBZ (61 patients), VPA (51 patients), or PB (29 patients) for 12-161 months." | 7.70 | Long-term treatment of children with epilepsy with valproate or carbamazepine may cause subclinical hypothyroidism. ( Castro-Gago, M; Del Río-Garma, M; Del Río-Garma, MC; Eirís-Puñal, J; Lojo-Rocamonde, S; Novo-Rodríguez, I, 1999) |
| "Perimenstrual catamenial epilepsy, the exacerbation of seizures in association with menstruation, may in part be due to withdrawal of the progesterone metabolite allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one), an endogenous anticonvulsant neurosteroid that is a positive allosteric modulator of gamma-aminobutyric acid(A) receptors." | 7.70 | Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy. ( Reddy, DS; Rogawski, MA, 2000) |
| "The interaction between clearance of phenytoin, valproic acid, phenobarbital and carbamazepine, and changes in body weight was determined in a 19-year-old obese woman with epilepsy (body weight 93 kg, BMI 36." | 7.69 | Clearance of phenytoin and valproic acid is affected by a small body weight reduction in an epileptic obese patient: a case study. ( Ashikari, Y; Chiba, S; Kodama, Y; Kuranari, M; Sakata, T; Takeyama, M, 1996) |
| "This study was performed to evaluate the aggregation changes in the whole blood samples of children with epilepsy receiving valproic acid." | 7.69 | The platelet aggregation in children with epilepsy receiving valproic acid. ( Akin, R; Gokcay, E; Koseoglu, V; Kurekci, AE; Ozcan, O; Tanindi, S, 1996) |
| "Twelve women receiving stable valproic acid (VPA) monotherapy for epilepsy received a combination norethindrone 1." | 7.69 | Effect of topiramate on the pharmacokinetics of an oral contraceptive containing norethindrone and ethinyl estradiol in patients with epilepsy. ( Doose, DR; Nayak, RK; Rosenfeld, WE; Walker, SA, 1997) |
| "Very little data are available on the usefulness of oxcarbazepine in young children with epilepsy." | 7.69 | Oxcarbazepine in the treatment of early childhood epilepsy. ( Gaily, E; Granström, ML; Liukkonen, E, 1997) |
| "Information from standardised tests of intelligence, school attainments, attention, memory and visuomotor function, together with parent and teacher questionnaire information about various aspects of behaviour, was obtained for 63 schoolchildren with newly diagnosed epilepsy before treatment with sodium valproate or carbamazepine, and again at intervals for a total period of 12 months." | 7.68 | Psychological effects of sodium valproate and carbamazepine in epilepsy. ( Stores, G; Styles, E; Williams, PL; Zaiwalla, Z, 1992) |
| "We retrospectively collected plasma level assessments performed in 96 adult patients with epilepsy on stable monotherapy, including 9 patients on clobazam (CLB), 34 on carbamazepine (CBZ), 24 on phenobarbital (PB), 9 on phenytoin (PHT), and 20 on valproate (VPA); these results were compared to those obtained in 54 adult patients on stable bitherapy with the association of CLB with either CBZ (n = 17), PB (n = 17), PHT (n = 5), or VPA (n = 15)." | 7.68 | Interactions between clobazam and standard antiepileptic drugs in patients with epilepsy. ( Bonneton, J; Dravet, C; Genton, P; Mesdjian, E; Roger, J; Sennoune, S, 1992) |
| "The anticonvulsant potency of 2-propyl-2-pentenoic acid (2-en-VPA; trans isomer), a major metabolite of the antiepileptic valproic acid (VPA), was evaluated in different animal models of epilepsy and compared with the respective data for VPA." | 7.67 | Comparative evaluation of anticonvulsant and toxic potencies of valproic acid and 2-en-valproic acid in different animal models of epilepsy. ( Löscher, W; Marescaux, C; Nau, H; Vergnes, M, 1984) |
| "A total of 64 problem patients with epilepsy (42 retrospective evaluations, 22 prospective cases) was treated with the combination of carbamazepine and valproic acid." | 7.67 | [Combination therapy with carbamazepine and valproic acid in problem cases at an outpatient epilepsy clinic]. ( Fröscher, W; Hoffmann, F; Stoll, KD, 1984) |
| "Ninety children with epilepsy were treated with carbamazepine (CBZ) alone or with other anticonvulsant drugs." | 7.67 | Correlation between plasma carbamazepine-10,11-epoxide concentration and drug side-effects in children with epilepsy. ( Brett, EM; Elyas, AA; Lascelles, PT; Schoeman, JF, 1984) |
| "We studied 85 pediatric patients with different types of epilepsy treated with valproic acid." | 7.67 | Valproic acid in the treatment of epilepsy during the pediatric age. ( Olmos-Garcia de Alba, G; Valdez, JM, 1986) |
| "To assess the most efficient means of monitoring thyroid status in an epilepsy clinic, total thyroxine (T4), free thyroxine stimulating hormone (TSH) were measured in 71 adult patients treated long-term with either phenytoin (DPH), carbamazepine (CBZ) or sodium valproate (VAL)." | 7.67 | The effective evaluation of thyroid status in patients on phenytoin, carbamazepine or sodium valproate attending an epilepsy clinic. ( Borsey, DQ; Browning, MC; Connacher, AA; Davidson, DL; Jung, RT, 1987) |
| "The problem of phenytoin-induced gingival hyperplasia is dicussed within the context of consultative planning between oral care practitioners and the physician managing the epilepsy." | 7.66 | Therapeutic alternatives in phenytoin-induced gingival hyperplasia. A case report and discussion. ( Kirkham, DB; Reynolds, NC, 1980) |
| "Sodium valproate is often used with phenytoin when epilepsy cannot be controlled by a single drug." | 7.66 | Phenytoin-valproate interaction: importance of saliva monitoring in epilepsy. ( Hamshaw-Thomas, A; Knott, C; Reynolds, F, 1982) |
| "During the course of a prospective serial study over a period of one year, findings compatible with immune-mediated thrombocytolysis accompanied the administration of valproic acid in about half of 45 children with epilepsy." | 7.66 | Valproic acid and immune thrombocytopenia. ( Barr, RD; Copeland, SA; Kelton, JC; Morris, N; Stockwell, ML, 1982) |
| "The authors studied antipyrine disposition before and after delivery in 4 epileptic women whose anticonvulsant plasma level per dosage ratio was lowered during pregnancy, and compared the results to those found in nonpregnant women undergoing antiepileptic treatment (N = 6) and healthy women (N = 6)." | 7.66 | Antipyrine disposition in relation to lowered anticonvulsant plasma level during pregnancy. ( Chiba, K; Ishizaki, T; Nakazawa, Y; Tabuchi, T; Wagatsuma, T, 1982) |
| "Of 88 patients with intractable epilepsy, 60 have been treated with clonazepam for up to three years and 60 have been treated with sodium valproate for up to 18 months." | 7.65 | Sodium valproate and clonazepam in the treatment of intractable epilepsy. ( Anthony, M; Lance, JW, 1977) |
| "This study reviewed all published valproic acid (VPA) population pharmacokinetic (PPK) models in adult patients and assessed them using external validation methods to determine predictive performance." | 6.82 | Published population pharmacokinetic models of valproic acid in adult patients: a systematic review and external validation in a Chinese sample of inpatients with bipolar disorder. ( de Leon, J; Dong, F; Guo, W; Li, AN; Ruan, CJ; Zang, YN, 2022) |
| "Although generalized convulsive status epilepticus (GCSE) is a life-threatening emergency, evidence-based data to guide initial drug treatment choices are lacking in the Chinese population." | 6.82 | Phenobarbital Versus Valproate for Generalized Convulsive Status Epilepticus in Adults: A Prospective Randomized Controlled Trial in China. ( Chen, W; Chun, B; Gao, D; Jiang, M; Liu, G; Ren, G; Su, Y; Tian, F; Ye, H; Zhang, Y, 2016) |
| " The validity of this approach remains uncertain and could be improved by understanding sources of pharmacokinetic variability." | 6.77 | Population pharmacokinetics of valproic acid in pediatric patients with epilepsy: considerations for dosing spinal muscular atrophy patients. ( Barrett, JS; Jayaraman, B; Swoboda, KJ; Williams, JH, 2012) |
| "No patient in the VPA group developed respiratory depression, hypotension, or hepatic dysfunction, whereas in the DZP group, 5." | 6.76 | Valproate versus diazepam for generalized convulsive status epilepticus: a pilot study. ( Chen, WB; Fan, CQ; Gao, R; Ren, Y; Su, YY; Wang, L; Zhang, YZ; Zhao, JW, 2011) |
| "Valproic acid is a widely used anticonvulsant drug with a broad therapeutic spectrum." | 6.73 | Inhibitory effect of valproic acid on cytochrome P450 2C9 activity in epilepsy patients. ( Babaoglu, MO; Bilir, E; Bozkurt, A; Gunes, A; Yasar, U; Zengil, H, 2007) |
| " The DFL for divalproex-ER dosed as a q12h regimen was 22% less than that for once-daily divalproex-ER (P=0." | 6.72 | Every-12-hour administration of extended-release divalproex in patients with epilepsy: impact on plasma valproic acid concentrations. ( Cavanaugh, JH; Dutta, S; Granneman, GR; Locke, C; Reed, RC, 2006) |
| " Patients were converted during an | 6.71 | Lamotrigine monotherapy compared with carbamazepine, phenytoin, or valproate monotherapy in patients with epilepsy. ( Hammer, AE; Kaminow, L; Schimschock, JR; Vuong, A, 2003) |
| " Pharmacokinetic parameters were determined by a noncompartmental method." | 6.71 | Topiramate pharmacokinetics in children with epilepsy aged from 6 months to 4 years. ( Bouhours, P; Chiron, C; d'Athis, P; Dulac, O; Echenne, B; Grinspan, A; Mikaeloff, Y; Pons, G; Rey, E; Soufflet, C; Vallée, L, 2004) |
| " The peak concentration (Cmax) of CZP and the time intervals from dosing to Cmax (Tmax) were 20." | 6.70 | Pharmacokinetic and pharmacodynamic effects of clonazepam in children with epilepsy treated with valproate: a preliminary study. ( Wang, L; Wang, XD, 2002) |
| "Lamotrigine was effective in all seizure types examined, particularly for typical and atypical absence seizures." | 6.68 | Lamotrigine for the treatment of epilepsy in childhood. ( Alving, J; Besag, FM; Dulac, O; Hosking, G; Spencer, SC; Wallace, SJ, 1995) |
| " Furthermore, we sought to evaluate whether a relationship existed between VPA dosage and plasma clearance for both total and unbound or free drug." | 6.68 | Relationship between valproic acid dosage, plasma concentration and clearance in adult monotherapy patients with epilepsy. ( Gidal, BE; Maly, MM; Pitterle, ME; Spencer, NW, 1995) |
| " The median elimination half-life (t1/2) in patients receiving concomitant valproate (VPA) was 43." | 6.68 | Pharmacokinetic interactions between lamotrigine and other antiepileptic drugs in children with intractable epilepsy. ( Boreus, L; Eriksson, AS; Hoppu, K; Nergårdh, A, 1996) |
| "The steady-state pharmacokinetics of valproate (VPA) and topiramate (TPM) were compared during VPA monotherapy, concomitant VPA and TPM therapy, and TPM monotherapy to evaluate pharmacokinetic interactions." | 6.68 | Comparison of the steady-state pharmacokinetics of topiramate and valproate in patients with epilepsy during monotherapy and concomitant therapy. ( Anderson, G; Kramer, LD; Levy, RH; Liao, S; Nayak, RK; Palmer, M; Rosenfeld, WE, 1997) |
| " In the dosage used, l-tryptophan was tolerated well by these children, and seizure frequency, as a whole, remained unaltered." | 6.65 | l-Tryptophan in hyperactive child syndrome associated with epilepsy: a controlled study. ( Ghose, K, 1983) |
| "Phenytoin has been widely prescribed alone; our results indicate that sodium valproate may also be used as a single drug in the treatment of several types of epilepsy." | 6.65 | Comparison of sodium valproate and phenytoin as single drug treatment in epilepsy. ( Johnson, RH; Lambie, DG; Melville, ID; Nanda, RN; Shakir, RA, 1981) |
| "Valproic acid (VPA) is a commonly used antiepileptic drug (AED)." | 6.61 | Valproic acid and Stevens-Johnson syndrome: a systematic review of descriptive studies. ( Kashyap, A; Rashid, M; Undela, K, 2019) |
| "Phenobarbital was associated with a higher rate of drug withdrawal although there was no evidence to suggest that phenobarbital caused more adverse events compared to carbamazepine, valproic acid or phenytoin." | 6.47 | Side effects of phenobarbital in epilepsy: a systematic review. ( Li, YP; Zeng, LN; Zhang, LL, 2011) |
| "When treatment with valproic acid is the most appropriate treatment to achieve optimal seizure control, a number of measures can be implemented to minimise risk to the fetus." | 6.43 | Valproic acid in epilepsy : pregnancy-related issues. ( Genton, P; Semah, F; Trinka, E, 2006) |
| "Epilepsy is a common medical problem and many studies have demonstrated that infants of women with epilepsy (WWE) have a two to threefold higher risk of congenital malformations compared with the background population." | 6.43 | Recent advances on neural tube defects with special reference to Valproic Acid. ( Chiarelli, F; Latini, G; Pelliccia, P; Tana, M; Verrotti, A, 2006) |
| "Valproic acid is a branched-chained fatty acid, structurally unrelated to any other antiepileptic drug." | 6.39 | Valproic acid. A reappraisal of its pharmacological properties and clinical efficacy in epilepsy. ( Davis, R; McTavish, D; Peters, DH, 1994) |
| "Carnitine treatment does not always prevent the emergence of serious hepatotoxicity, but it does alleviate valproate-induced hyperammonemia." | 6.39 | Carnitine deficiency in epilepsy: Risk factors and treatment. ( Coulter, DL, 1995) |
| "Valproic acid has become a regular component of antiepileptic therapy." | 6.36 | [Valproic acid in the treatment of epilepsy with special emphasis on serum level determination (author's transl)]. ( Fröscher, W; Gugler, R; Schulz, HU, 1978) |
| " Other topics were: psychotropic effect of antiepileptic drugs, folic acid and vitamin D administration in epilepsy, and EEG investigations." | 6.15 | Controlled trials in epilepsy: a review. ( Bentsen, KD; Flachs, H; Gram, L; Parnas, J, 1982) |
| "Epilepsy is a chronic neurological disorder that is characterized by episodes of seizure." | 5.72 | Clinical Evaluation of Levetiracetam in the Treatment of Epilepsy. ( Guan, S; Liu, J; Qian, F; Wang, Y; Wu, H; Yang, J, 2022) |
| "Results: Mild cognitive impairment - MCI was diagnosed in 4 patients (28." | 5.72 | HYPERAMMONAEMIA AND COGNITIVE IMPAIRMENT IN EPILEPSY PATIENTS TREATED WITH VALPROIC ACID - PRELIMINARY STUDY. ( Dutkiewicz, J; Pilut, D; Szczygieł-Pilut, EE; Zajączkowska-Dutkiewicz, A, 2022) |
| "Valproic acid (VPA) is an antiepileptic drug, used for focal and generalized seizure." | 5.72 | The impact of valproic acid treatment on weight gain in pediatric patients with epilepsy. ( Battaglia, D; Blasi, V; DI Ruscio, F; Ferrara, P; Gatto, A, 2022) |
| "The study intended to analyze the effects of a group nursing intervention on quality of life (QoL) of patients with epilepsy (EP) after treatment with sodium valproate combined with lamotrigine." | 5.69 | Value of Group Intervention on Prognosis of Quality of Life in Epileptic Patients Treated With Sodium Valproate and Lamotrigine. ( Fan, X; Li, X; Li, Y; Wang, D; Wang, M; Xie, Z; Yin, J; Yu, J; Yu, M, 2023) |
| "Phospholipid-valproic acid (DP-VPA)is a prodrug for treating epilepsy." | 5.69 | Population pharmacokinetics and exposure-safety of lipophilic conjugates prodrug DP-VPA in healthy Chinese subjects for dose regime exploring. ( Cao, G; Chen, Y; Fan, Y; Guo, B; Hu, J; Li, X; Li, Y; Liu, X; Wang, Y; Wu, H; Wu, J; Wu, X; Xu, X; Yu, J; Yu, P; Zhan, H; Zhang, J, 2023) |
| "Epilepsy is one of the most frequent neurological disorders characterized by an enduring predisposition to generate epileptic seizures." | 5.62 | Histopathological and Biochemical Assessment of Neuroprotective Effects of Sodium Valproate and Lutein on the Pilocarpine Albino Rat Model of Epilepsy. ( Al-Rafiah, AR; Mehdar, KM, 2021) |
| "Carbamazepine was ineffective, and seizures were exacerbated with levetiracetam (LEV)." | 5.56 | Improvement of epilepsy with lacosamide in a patient with ring chromosome 20 syndrome. ( Goji, A; Kagami, S; Mori, T; Tayama, T; Toda, Y, 2020) |
| "Valproic acid (VPA) was a classic antiepileptic drug for fifty years." | 5.56 | Influence of age and co-medication on the concentration and efficacy of valproic acid in Chinese epilepsy children. ( Hu, W; Li, Z; Wang, Y, 2020) |
| " This study investigated the effect of delayed or missed doses on the pharmacokinetics (PK) of valproic acid (VPA) in patients with epilepsy and established remedial dosing recommendations for nonadherent patients." | 5.56 | Remedial dosing recommendations for delayed or missed doses of valproic acid in patients with epilepsy based on Monte Carlo simulations. ( Ding, JJ; Jiao, Z; Wang, CY; Yu, EQ; Zhu, GX, 2020) |
| "Epileptic seizures are frequent in patients with glioblastoma, and anticonvulsive treatment is often necessary." | 5.51 | AMPA receptor antagonist perampanel affects glioblastoma cell growth and glutamate release in vitro. ( Bergner, C; Hörnschemeyer, J; Kirschstein, T; Köhling, R; Krause, BJ; Lange, F; Linnebacher, M; Mullins, CS; Porath, K; Weßlau, K, 2019) |
| "Focal epilepsy was diagnosed in 244 (69." | 5.51 | Why do some women with epilepsy use valproic acid despite current guidelines? A single-center cohort study. ( Bosak, M; Słowik, A; Turaj, W, 2019) |
| "Curcumin is a phytochemical with promising effects on epilepsy treatment." | 5.48 | Micronization potentiates curcumin's anti-seizure effect and brings an important advance in epilepsy treatment. ( Aguiar, GPS; Bertoncello, KT; Oliveira, JV; Siebel, AM, 2018) |
| " Therefore, this study aimed to establish a population pharmacokinetic (PPK) model of LTG in Chinese children with epilepsy and to comprehensively evaluate the effects of genetic variations in drug-metabolizing enzymes, transporters, and a transcriptional regulator on LTG pharmacokinetics." | 5.48 | A Population Pharmacokinetic-Pharmacogenetic Model of Lamotrigine in Chinese Children With Epilepsy. ( Chen, Y; Lu, T; Wang, H; Wang, Z; Xu, S; Zhao, L; Zhao, M, 2018) |
| " While the concentration of 4-ene-VPA was not suitable as an early warning index, the results provide clear theoretical guidance for the rational and safe clinical use of VPA." | 5.46 | Association of CYP2C9, CYP2A6, ACSM2A, and CPT1A gene polymorphisms with adverse effects of valproic acid in Chinese patients with epilepsy. ( Ma, HY; Pan, J; Wang, C; Wang, P; Yang, LP; Yang, X, 2017) |
| "Valproic acid (VPA) is a widely prescribed broad-spectrum antiepileptic drug." | 5.46 | Influence of age and co-medication on the steady-state pharmacokinetics of valproic acid in Tunisian patients with epilepsy. ( Atheymen, R; Ben Mahmoud, L; Ghozzi, H; Hakim, A; Sahnoun, Z; Zeghal, K, 2017) |
| " The aim of the study was to conduct an in vivo evaluation of the relationship between treatments with synthetic cannabinoid arachidonyl-2'-chloroethylamide (ACEA) alone or in combination with valproic acid (VPA) and hippocampal neurogenesis in a mouse pilocarpine model of epilepsy." | 5.46 | A Long-Term Treatment with Arachidonyl-2'-Chloroethylamide Combined with Valproate Increases Neurogenesis in a Mouse Pilocarpine Model of Epilepsy. ( Andres-Mach, M; Dudra-Jastrzębska, M; Haratym, J; Haratym-Maj, A; Maj, M; Rola, R; Zagaja, M; Łuszczki, JJ, 2017) |
| "• Valproic acid has a cumulative effect on inhibiting brain activity in epileptogenic regions." | 5.46 | Resting-state fMRI revealed different brain activities responding to valproic acid and levetiracetam in benign epilepsy with central-temporal spikes. ( Dante, M; Hu, Z; Li, K; Li, Q; Li, Z; Lu, G; Wu, H; Xu, Q; Yang, F; Zhang, Q; Zhang, Z, 2017) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 5.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| " The correlation with dose may be a spurious finding related to the fact that physicians, in adjusting dosage according to clinical response, are more likely to use larger doses in patients with high clearance values." | 5.43 | An investigation of the influence of patient-related factors and comedications on lamotrigine clearance in patients with epilepsy. ( Alexandre, V; Baldoni, AO; de Santi Ferreira, FI; Freitas-Lima, P; Martinez, EZ; Pereira, LR; Perucca, E; Queiroz, RH; Sakamoto, AC, 2016) |
| "Valproic acid (VPA) follows a non-linear pharmacokinetic profile in terms of protein-binding saturation." | 5.42 | A population pharmacokinetic model of valproic acid in pediatric patients with epilepsy: a non-linear pharmacokinetic model based on protein-binding saturation. ( Ding, J; Jiao, Z; Li, X; Lin, W; Miao, L; Wang, C; Wang, Y; Zhao, L; Zhao, Z, 2015) |
| "Valproic acid treated animals were treated from 5 days preceding behavioral testing in the Morris water maze at a clinically relevant concentration." | 5.42 | Standard dose valproic acid does not cause additional cognitive impact in a rodent model of intractable epilepsy. ( Jellett, AP; Jenks, K; Lucas, M; Scott, RC, 2015) |
| " In this study, we developed a population-based pharmacokinetic (PK)-pharmacodynamic (PD) model to determine the optimal concentration of VPA according to the clinical characteristics of each patient." | 5.42 | Determination of the Optimal Concentration of Valproic Acid in Patients with Epilepsy: A Population Pharmacokinetic-Pharmacodynamic Analysis. ( Ishitsu, T; Matsuda, K; Nakagawa, K; Nakashima, H; Nishimura, M; Ogusu, N; Oniki, K; Ono, T; Saruwatari, J; Shimomasuda, M; Yasui-Furukori, N, 2015) |
| "Participants with focal epilepsy were randomised to receive lamotrigine, levetiracetam or zonisamide." | 5.41 | Lamotrigine versus levetiracetam or zonisamide for focal epilepsy and valproate versus levetiracetam for generalised and unclassified epilepsy: two SANAD II non-inferiority RCTs. ( Appleton, R; Baker, G; Balabanova, S; Brown, R; Burnside, G; Hindley, D; Howell, S; Hughes, DA; Leach, JP; Maguire, M; Marson, AG; Mohanraj, R; Plumpton, CO; Sills, G; Smith, D; Smith, PE; Taylor, C; Tudur-Smith, C; Williamson, PR, 2021) |
| "Valproic acid is prescribed for epilepsy and as prophylaxis for bipolar disorder and migraine headaches." | 5.41 | Kidney tubular injury induced by valproic acid: systematic literature review. ( Anguissola, G; Bianchetti, MG; Lava, SAG; Leu, D; Milani, GP; Scoglio, M; Simonetti, BG; Simonetti, GD, 2023) |
| "Hyperammonemia can occur after acute overdose or chronic use of valproic acid (VPA)." | 5.41 | Risk factors of hyperammonemia in epilepsy patients with valproic acid therapy. ( Kim, DW; Kwack, DW, 2023) |
| " In parallel, adenosine deficit is increasingly recognized in epilepsy pathophysiology." | 5.41 | Bipolar mania and epilepsy pathophysiology and treatment may converge in purine metabolism: A new perspective on available evidence. ( Boison, D; Daniels, SD, 2023) |
| "To establish using dried blood spot (DBS) as a surrogate to plasma for therapeutic drug monitoring (TDM) of carbamazepine (CBZ), we compared the population pharmacokinetic (PPK) estimates from concurrent DBS and plasma levels." | 5.40 | Estimation and comparison of carbamazepine population pharmacokinetics using dried blood spot and plasma concentrations from people with epilepsy: the clinical implication. ( Chan, E; Ho, PC; Kong, ST; Lim, SH, 2014) |
| "This retrospective study included 237 and 169 VPA-treated Japanese patients with epilepsy for population pharmacokinetic and pharmacokinetic-pharmacodynamic analyses, respectively." | 5.40 | Impact of the superoxide dismutase 2 Val16Ala polymorphism on the relationship between valproic acid exposure and elevation of γ-glutamyltransferase in patients with epilepsy: a population pharmacokinetic-pharmacodynamic analysis. ( Deguchi, M; Ishitsu, T; Kaneko, S; Nakagaswa, K; Nakashima, H; Nishimura, M; Noai, M; Ogusu, N; Oniki, K; Saruwatari, J; Yasui-Furukori, N, 2014) |
| "Epilepsy was induced by i." | 5.38 | Evaluation of the antiepileptic effect of curcumin and Nigella sativa oil in the pilocarpine model of epilepsy in comparison with valproate. ( Aboul Ezz, HS; Faraag, AR; Khadrawy, YA; Noor, NA, 2012) |
| "He had been on a lamotrigine treatment due to epilepsy, and after cessation of lamotrigine, his cardiac enzyme levels returned to normal." | 5.38 | Lamotrigine related myocarditis: case report. ( Bayhan, T; Karagöz, T; Sahin, M; Yıldırım, I, 2012) |
| "Curcumin was co-administered with sub-therapeutic dose of valproate 60min before PTZ injection." | 5.37 | Pharmacokinetic and pharmacodynamic interactions of valproate, phenytoin, phenobarbitone and carbamazepine with curcumin in experimental models of epilepsy in rats. ( Gupta, YK; Mehla, J; Pahuja, M; Reeta, KH, 2011) |
| "Valproic acid (VPA) is an anticonvulsant and mood-stabilizing drug for the long-term treatment." | 5.37 | Valproic Acid related metabolic syndrome in patients with epilepsy. ( Kasradze, S; Mania, M; Okujava, N, 2011) |
| " Plasma concentrations (pc), interactions between drugs in the ICU context, adverse effects and seizure occurrences were observed and recorded." | 5.37 | Levetiracetam compared to valproic acid: plasma concentration levels, adverse effects and interactions in aneurysmal subarachnoid hemorrhage. ( Bjeljac, M; Keller, E; Mink, S; Muroi, C; Seule, M, 2011) |
| "Treatment with curcumin, NSO or valproate ameliorated most of the changes induced by pilocarpine and restored Na⁺, K⁺-ATPase activity in the hippocampus to control levels." | 5.37 | The neuroprotective effect of curcumin and Nigella sativa oil against oxidative stress in the pilocarpine model of epilepsy: a comparison with valproate. ( Ezz, HS; Khadrawy, YA; Noor, NA, 2011) |
| "Valproic acid (VPA) is a widely used and well-tolerable antiepileptic drug in epileptic patients." | 5.35 | The effects of biotin supplementation on serum and liver tissue biotinidase enzyme activity and alopecia in rats which were administrated to valproic acid. ( Akin, R; Arslan, M; Balamtekin, N; Kurt, I; Ozcan, O; Unay, B; Vurucu, S, 2009) |
| "This trial evaluated the effect of cannabidiol on steady-state pharmacokinetics of stiripentol or valproate in patients with epilepsy, and the safety and tolerability of cannabidiol." | 5.34 | A Phase II Randomized Trial to Explore the Potential for Pharmacokinetic Drug-Drug Interactions with Stiripentol or Valproate when Combined with Cannabidiol in Patients with Epilepsy. ( Arenas Cabrera, CM; Ben-Menachem, E; Critchley, D; Crockett, J; Gunning, B; Morrison, G; Tayo, B; Toledo, M; VanLandingham, K; Wray, L, 2020) |
| "The aim of this study was to investigate the effects of sodium valproate (SV) and carbamazepine (CBZ) on neuromuscular transmission using single-fibre electromyography (SFEMG) in patients with epilepsy." | 5.34 | An investigation on the effects of carbamazepine and sodium valproate on neuromuscular transmission. ( Ay, H; Ethemoğlu, Ö, 2020) |
| "Epilepsy is one of the most common presentations of patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS)." | 5.34 | Valproic acid aggravates epilepsy due to MELAS in a patient with an A3243G mutation of mitochondrial DNA. ( Lin, CM; Thajeb, P, 2007) |
| "Lamotrigine was escalated according to a target dose of 200 mg/day over 8-weeks." | 5.34 | Conversion to lamotrigine monotherapy from valproate monotherapy in older adolescent patients with epilepsy. ( Baumann, RJ; Fakhoury, TA; Hammer, AE; Kustra, RP; Messenheimer, JA; Vuong, A, 2007) |
| "Valproic acid has been previously associated with hematologic toxicity, including a reversible myelodysplasia-like syndrome without chromosomal abnormalities." | 5.33 | Acute leukemia associated with valproic acid treatment: a novel mechanism for leukemogenesis? ( Bair, AK; Coyle, TE; Mehdi, S; Stein, C; Vajpayee, N; Wright, J, 2005) |
| " VPA was not found to have any clinically significant influence on TPM pharmacokinetic and metabolic profiles." | 5.33 | A comparative study of the effect of carbamazepine and valproic acid on the pharmacokinetics and metabolic profile of topiramate at steady state in patients with epilepsy. ( Bialer, M; Britzi, M; Doose, DR; Gatti, G; La Neve, A; Levy, RH; Maryanoff, BE; Mimrod, D; Perucca, E; Soback, S; Specchio, LM; Specchio, N, 2005) |
| "A 56-year-old woman with poorly controlled epilepsy, receiving valproate at subtherapeutic levels for 6 years, developed a life-threatening hyperammonemic coma following a moderate dosage increase." | 5.33 | Acute hyperammonemic coma with chronic valproic acid therapy. ( Abramson, RK; Cuturic, M, 2005) |
| "Valproic acid (VPA) is an antiepileptic drug (AED) used for generalized and absence seizures." | 5.32 | Effects of age and polytherapy, risk factors of valproic acid (VPA) hepatotoxicity, on the excretion of thiol conjugates of (E)-2,4-diene VPA in people with epilepsy taking VPA. ( Abbott, F; Farrell, K; Gopaul, S, 2003) |
| "Men with epilepsy are known to have reduced fertility." | 5.32 | Alterations in semen parameters in men with epilepsy treated with valproate or carbamazepine monotherapy. ( Bjørnenak, T; Gjerstad, L; Haugen, TB; Røste, LS; Saetre, ER; Taubøll, E, 2003) |
| "Pregnancy was otherwise uneventful." | 5.32 | Multiple congenital malformations including generalized hypertrichosis with gum hypertrophy in a child exposed to valproic acid in utero. ( Audeoud, F; Bernardin, A; Gaugler, C; Messer, J; Stoll, C, 2003) |
| " The severity of the cognitive side effects of TPM may be related to dosing to a certain extent, but this relationship may be disclosed only with larger sample sizes." | 5.32 | Cognitive profile of topiramate as compared with lamotrigine in epilepsy patients on antiepileptic drug polytherapy: relationships to blood serum levels and comedication. ( Elger, CE; Helmstaedter, C; Kockelmann, E, 2004) |
| " Everyone received a drug dosage which gave an adequate therapeutic plasma concentration and satisfactory seizure control." | 5.31 | [Bimodal evoked potentials during long-term therapy with conventional or slow release preparations of carbamazepine and valproic acid in children and adolescents with epilepsy]. ( Zgorzalewicz, M, 2000) |
| "Carbamazepine and depakine treatment during at least 6 months does not predispose to ovary polycystosis syndrome." | 5.31 | [The pharmacological and hormonal effects of carbamazepine and valproic acid in the treatment of reproductive age women with epilepsy]. ( Karlov, VA; Kushlinskiĭ, NE; Vlasov, PN, 2001) |
| "Valproic acid is an antiepileptic drug in widespread use." | 5.30 | Thrombocytopenic purpura and anemia in a breast-fed infant whose mother was treated with valproic acid. ( Neiderud, J; Stahl, MM; Vinge, E, 1997) |
| "To investigate the development of reproductive endocrine changes in Indian women with epilepsy initiating on either Valproate (VPA) or Lamotrigine (LTG) monotherapy." | 5.27 | Evaluate the effects of antiepileptic drugs on reproductive endocrine system in newly diagnosed female epileptic patients receiving either Valproate or Lamotrigine monotherapy: A prospective study. ( Sadhotra, A; Sidhu, HS; Srinivasa, R, 2018) |
| "Side effects of carbamazepine (CBZ), valproate (VPA) and clonazepam (CZP) are rare during long-term use but rather common and usually transient during the early phases of treatment." | 5.27 | Side effects of carbamazepine, valproate and clonazepam during long-term treatment of epilepsy. ( Keränen, T; Sivenius, J, 1983) |
| "Free and total valproic acid (VPA) pharmacokinetic evaluation was carried out at steady state in six young epileptics who were also receiving other anticonvulsants." | 5.27 | Free valproic acid: steady-state pharmacokinetics in patients with intractable epilepsy. ( Budnik, D; Hall, K; Irvine-Meek, J; Leroux, M; Otten, N; Seshia, S, 1984) |
| " Reducing the dosage by 19 mg/kg (A to B) decreased VPA plasma levels by 6." | 5.26 | Monitoring free valproic acid in epilepsy patients medicated with coanticonvulsants. ( Haidukewych, D; Rodin, EA, 1982) |
| " Valproic acid appears to be use cautionally in obese females with epilepsy." | 5.24 | Evaluate the effects of long-term valproic acid treatment on metabolic profiles in newly diagnosed or untreated female epileptic patients: A prospective study. ( Sadhotra, A; Sidhu, HS; Srinivas, R, 2017) |
| " This case describes a 38 year-old female with a past medical history of epilepsy effectively treated with meropenem to rapidly and safely lower toxic VPA levels after an acute ingestion." | 5.22 | Treatment of valproic acid overdose with meropenem in an epileptic patient. ( Clark, K; Cunningham, D; Lord, K, 2022) |
| "To estimate the safety and efficacy of sodium valproate combined with levetiracetam in paediatric patients with epilepsy based on randomized controlled trials (RCTs)." | 5.22 | Combined effects of levetiracetam and sodium valproate on paediatric patients with epilepsy: a systematic review and meta-analysis. ( Yang, J; Zhu, X; Zhu, Y, 2022) |
| "A literature search was performed in the PubMed, Embase, and OVID-Medline databases to identify articles related to epilepsy and lamotrigine that were published from the establishment of the database to April 2021." | 5.22 | The efficacy of lamotrigine after failure of the first administration of valproate in treating epilepsy: a systematic review and meta-analysis. ( He, J; Wu, X; Zhou, D, 2022) |
| "Valproic acid (VPA) is a widely used antiepileptic drug not recommended in pregnancy because it is teratogenic." | 5.22 | Transcriptome meta-analysis of valproic acid exposure in human embryonic stem cells. ( Gomes, JDA; Kowalski, TW; Lord, VO; Mariath, LM; Recamonde-Mendoza, M; Sgarioni, E; Vianna, FSL, 2022) |
| " Potential add-on AEDs in case of uncontrolled seizures include lacosamide, perampanel, and valproic acid." | 5.22 | Management of epilepsy in brain tumor patients. ( Koekkoek, JAF; Taphoorn, MJB; van der Meer, PB, 2022) |
| "This article will review the different therapeutic options for status, from early treatment at home to the different first-line (benzodiazepines), second-line (phenobarbital, valproic acid, phenytoin, levetiracetam and lacosamide) or third-line treatments, which include both pharmacological (anaesthetics, propofol, ketamine, lidocaine, topiramate, brivaracetam or perampanel) and non-pharmacological (ketogenic diet, immunomodulatory treatments or epilepsy surgery) therapies." | 5.22 | [Paediatric status epilepticus]. ( García-Peñas, JJ; González-Alguacil, E; Soto-Insuga, V, 2022) |
| " Participants had "failed" initial monotherapy for partial epilepsy and were randomized to substitution monotherapy with levetiracetam or an older AED (carbamazepine or valproate sodium)." | 5.22 | Monotherapy with Levetiracetam Versus Older AEDs: A Randomized Comparative Trial of Effects on Bone Health. ( Christie, J; Gorelik, A; Hakami, T; Kantor, S; O'Brien, TJ; Petty, SJ; Sakellarides, M; Seibel, MJ; Todaro, M; Wark, JD; Yerra, R, 2016) |
| " Three groups of patients were studied: (A) epileptic under phenytoin monotherapy (n = 31); (B) with bipolar disorder under valproic acid treatment (n = 28); (C) elderly (n = 41)." | 5.22 | Carnitine and/or Acetylcarnitine Deficiency as a Cause of Higher Levels of Ammonia. ( Fagiolino, P; González, R; Guevara, N; Maldonado, C; Queijo, C; Vázquez, M, 2016) |
| "This post-hoc subgroup analysis of data from an unblinded, randomized, 52-week superiority study (KOMET) compared the effectiveness of levetiracetam (LEV) with extended-release sodium valproate (VPA-ER) and controlled-release carbamazepine (CBZ-CR) as monotherapy in patients aged ≥ 60 years with newly diagnosed epilepsy." | 5.22 | Comparative effectiveness of levetiracetam, valproate and carbamazepine among elderly patients with newly diagnosed epilepsy: subgroup analysis of the randomized, unblinded KOMET study. ( Marson, AG; Noack-Rink, M; Pohlmann-Eden, B; Ramirez, F; Tofighy, A; Trinka, E; Werhahn, KJ; Wild, I, 2016) |
| "This Phase I, open-label, dose-escalation study investigated the effects of steady-state brivaracetam on the pharmacokinetics of carbamazepine in patients with epilepsy, with and without valproate co-administration." | 5.22 | Pharmacokinetic interaction of brivaracetam on carbamazepine in adult patients with epilepsy, with and without valproate co-administration. ( Brodie, MJ; Sargentini-Maier, ML; Stockis, A, 2016) |
| "Eighty-one patients participated in the study: 51 patients with chronic epilepsy (G1) treated with carbamazepine (CBZ) or valproic acid (VPA), and 30 patients with newly diagnosed epilepsy (G2)." | 5.16 | The effect of vitamin B supplementation on homocysteine metabolism and clinical state of patients with chronic epilepsy treated with carbamazepine and valproic acid. ( Bochyńska, A; Graban, A; Gugała-Iwaniuk, M; Lechowicz, W; Lipczyńska-Łojkowska, W; Lipska, B; Restel, M; Ryglewicz, D, 2012) |
| "The extent of lamotrigine interactions was investigated dependent on age, gender, weight and dose of concomitant carbamazepine and/or valproic acid in 65 patients with epilepsy." | 5.16 | Impact of age, weight and concomitant treatment on lamotrigine pharmacokinetics. ( Brzaković, BB; Martinović, ZJ; Miljković, BR; Pokrajac, MV; Prostran, MŠ; Vezmar Kovačević, SD; Vučićević, KM, 2012) |
| "This study aimed to evaluate the effects of monotherapy with valproate or oxcarbazepine on the linear growth of children with idiopathic epilepsy." | 5.16 | The effects of oxcarbazepine and valproate therapies on growth in children with epilepsy. ( Bideci, A; Camurdan, O; Cansu, A; Cinaz, P; Hirfanoglu, TL; Karaoglu, A; Serdaroglu, A; Yesilkaya, E, 2012) |
| "To explore the efficacy and safety of the combined therapy of valproic acid (VPA) and lamotrigine (LTG) for various types of epilepsy." | 5.16 | [Efficacy and safety of the combined therapy of valproic acid and lamotrigine for epileptics]. ( Hu, Q; Kang, HC; Li, X; Liu, XY; Liu, ZG; Wang, M; Xu, F; Zeng, Z; Zhu, SQ, 2012) |
| "Two broad spectrum AEDs, the traditional drug of sustained-release formulation of valproate (SRVPA) and the new-generation drug of topiramate, were compared in patients with epilepsy as monotherapy in this multi-centre, observational cohort study from 2000 to 2011." | 5.16 | Outcomes of sustained-release formulation of valproate and topiramate monotherapy in patients with epilepsy: a multi-centre, cohort study. ( Cao, Q; Chen, G; Ding, M; Hu, X; Hu, Y; Huang, X; Li, H; Liu, J; Lu, Y; Peng, B; Shen, D; Sun, H; Wang, X; Wu, M; Xi, Z; Zeng, K; Zhang, Y; Zhou, Y, 2012) |
| "The aim of this study is to investigate the effects of epilepsy, valproic acid and oxcarbazepine on nitric oxide levels, lipid peroxidation and xanthine oxidase levels in newly diagnosed epileptic children and healthy controls." | 5.15 | Effects of epilepsy and antiepileptic drugs on nitric oxide, lipid peroxidation and xanthine oxidase system in children with idiopathic epilepsy. ( Arhan, E; Kurt, N; Kutsal, E; Ozcelik, A; Ozturk, B; Ozturk, HS; Serdaroglu, A; Sevinc, N, 2011) |
| "To investigate the effect of topiramate on bone mass and metabolism in premenopausal women with epilepsy." | 5.15 | The effect of topiramate monotherapy on bone mineral density and markers of bone and mineral metabolism in premenopausal women with epilepsy. ( Heo, K; Kim, WJ; Lee, BI; Lee, HW; Lee, SA; Rhee, Y; Shin, DJ; Song, HK; Song, K, 2011) |
| "This open label study suggests that the combination of valproate, lamotrigine, and a benzodiazepine can markedly reduce the frequency of epileptic drop attacks in patients with generalized or multifocal epilepsies." | 5.15 | Long-term control of epileptic drop attacks with the combination of valproate, lamotrigine, and a benzodiazepine: a 'proof of concept,' open label study. ( Bastos, FA; Machado, VH; Palmini, A; Rotert, R, 2011) |
| "To explore efficacy and tolerability outcomes of topiramate (TPM) in patients with epilepsy transitioning from valproic acid (VPA) because of insufficient efficacy and/or tolerability onto TPM." | 5.14 | Conversion from valproic acid onto topiramate in adolescents and adults with epilepsy. ( Bogdanow, M; Lüer, W; Ossig, W; Schauble, B; Schreiner, A; Stollhoff, K; Unkelbach, S, 2009) |
| "The purpose of this study was to determine whether children with epilepsy undergoing valproate therapy and who are otherwise healthy have lower levels of serum and muscle carnitine." | 5.14 | Serum and muscle carnitine levels in epileptic children receiving sodium valproate. ( Anil, AB; Anil, M; Dilek, M; Helvaci, M; Kalenderer, O; Ozbal, E, 2009) |
| "Valproic acid (VPA) has been associated with hyperammonemia with and without encephalopathy." | 5.14 | Hyperammonemia following intravenous valproate loading. ( Beasley, MT; Cofield, S; DeWolfe, JL; Faught, E; Knowlton, RC; Limdi, NA, 2009) |
| " We evaluated the reproductive endocrine and insulin-related metabolic parameters in men and women with untreated epilepsy randomized to valproate (n=44) or lamotrigine (n=37) monotherapy for 12 months." | 5.14 | Effects of valproate or lamotrigine monotherapy on the reproductive endocrine and insulin-related metabolic profile in Chinese adults with epilepsy: a prospective randomized study. ( Chan, IH; Chan, MH; Hui, AC; Hui, KF; Kwan, P; Lam, CW; Leung, H; Ng, PW; Yip, FP, 2009) |
| "Valproate (VPA) administration may be associated with adverse metabolic effects, among is hyperammonemia, which could suggest metabolic abnormalities as carnitine deficiency." | 5.14 | The risk of asymptomatic hyperammonemia in children with idiopathic epilepsy treated with valproate: relationship to blood carnitine status. ( Abdella, MM; Hamed, SA, 2009) |
| "For a retrospective observational investigation based on real clinical practice of relative efficacy of valpoic acid (VPA), carbamazepine (CBZ) and topiramate (TPM) we have selected 106 patients with age of seizure onset before 17 years with a undoubted diagnosis of symptomatic or cryptogenic occipital lobe epilepsy (OLE), who had received treatment according to ILAE recommendations, and observation time since the last treatment change was from 2 to 10 years." | 5.14 | [Comparative efficacy of carbamazepine, valproic acid and topiramate in symptomatic and cryptogenic occipital lobe epilepsy in children]. ( , 2010) |
| "To evaluate development of components of polycystic ovary syndrome (PCOS) and PCOS in women with epilepsy initiating valproate or lamotrigine therapy." | 5.13 | Hyperandrogenism, ovulatory dysfunction, and polycystic ovary syndrome with valproate versus lamotrigine. ( Adams, JM; Bhatt, M; Hayes, FJ; Isojärvi, J; Morrell, MJ; Ozkara, C; Sluss, PM; Warnock, CR, 2008) |
| "To evaluate the efficacy and tolerability of the treatment with valproic acid (VPA) in patients with status epilepticus (SE) or acute repetitive seizures (ARS) comparing it with phenytoin (PHT) treatment." | 5.13 | Treatment of status epilepticus and acute repetitive seizures with i.v. valproic acid vs phenytoin. ( Dabby, R; Gilad, R; Izkovitz, N; Lampl, Y; Rapoport, A; Sadeh, M; Weller, B, 2008) |
| "The present study was designed to reveal changes of cognitive processes in epilepsy (EP) patients with Topiramate (TPM) or Valproate (VPA) treatment using Wechsler Adult Intelligence Scale (WAIS-CR) and event-related potential (ERP)." | 5.13 | Attention changes in epilepsy patients following 3-month topiramate or valproate treatment revealed by event-related potential. ( Sun, W; Wang, W; Wang, Y; Wu, X, 2008) |
| "Valproic acid (VPA) is a well-established anticonvulsant drug discovered serendipitously and marketed for the treatment of epilepsy, migraine, bipolar disorder and neuropathic pain." | 5.12 | Insights into Structural Modifications of Valproic Acid and Their Pharmacological Profile. ( Bora, S; Hasija, Y; Kukal, S; Kukreti, R; Kukreti, S; Mishra, MK; Muthusamy, K; Paul, PR; Saso, L; Singh, A, 2021) |
| " This paper aims to undertake a comprehensive review regarding the possible risks of four classical (phenytoin, carbamazepine, phenobarbital, and valproate) and two newer (lamotrigine and levetiracetam) AEDs during pregnancy." | 5.12 | Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications. ( Demir, O; Kaplan, YC, 2021) |
| "This study was performed to evaluate carnitine deficiency in a large series of epilepsy children and adolescents treated with old and new antiepileptic drugs with or without ketogenic diet." | 5.12 | Plasma free carnitine in epilepsy children, adolescents and young adults treated with old and new antiepileptic drugs with or without ketogenic diet. ( Auricchio, G; Coppola, G; Epifanio, G; Federico, RR; Pascotto, A; Resicato, G, 2006) |
| "We conducted a study to assess the effect of phenobarbital, carbamazepine, and valproate on serum lipid profiles and lipoprotein (a) in 64 children with epilepsy (aged between 1 and 15 years) admitted to the child neurology outpatient clinic between July 2000 and July 2002." | 5.12 | Effect of antiepileptic drugs on plasma lipids, lipoprotein (a), and liver enzymes. ( Aslan, A; Demir, E; Orem, A; Orhan, F; Sonmez, FM; Topbas, M; Yildirmis, S, 2006) |
| "Quantitative EEG (QEEG) effects of therapeutic doses of carbamazepine (CBZ), oxcarbazepine (OXC), valproate (VA) and lamotrigine (LA) monotherapy were investigated in patients with beginning epilepsy." | 5.12 | Quantitative EEG effects of carbamazepine, oxcarbazepine, valproate, lamotrigine, and possible clinical relevance of the findings. ( Altmann, A; Bessenyei, M; Clemens, B; Hollódy, K; Jerney, J; Kollár, K; Ménes, A; Piros, P; Rosdy, B; Rózsavölgyi, M; Steinecker, K, 2006) |
| "In eight women treated with lamotrigine monotherapy, the lamotrigine dose/plasma concentration (D/C) ratio increased by 295% from baseline outside pregnancy to midgestation, whereas in six women treated with lamotrigine in combination with valproate, the increase was only 60%." | 5.12 | Valproate effects on kinetics of lamotrigine in pregnancy and treatment with oral contraceptives. ( Luef, G; Ohman, I; Pittschieler, S; Sabers, A; Tomson, T, 2006) |
| "We have performed a randomised, prospective study to compare the efficacy and tolerability of sodium valproate (VPA) and lamotrigine (LTG) monotherapy, and their effects on circulating androgenic hormones, in newly diagnosed epilepsy." | 5.12 | Sodium valproate versus lamotrigine: a randomised comparison of efficacy, tolerability and effects on circulating androgenic hormones in newly diagnosed epilepsy. ( Brodie, MJ; Butler, E; Hitiris, N; Leach, JP; Leach, VM; Parker, P; Sills, GJ; Stephen, LJ; Wilson, EA, 2007) |
| "To determine whether levetiracetam (LEV) affects plasma concentrations of carbamazepine, valproic acid, topiramate, and lamotrigine in children with epilepsy." | 5.12 | Lack of pharmacokinetic interaction of levetiracetam on carbamazepine, valproic acid, topiramate, and lamotrigine in children with epilepsy. ( De Smedt, H; Otoul, C; Stockis, A, 2007) |
| "To compare clinicians' choice of one of the standard epilepsy drug treatments (carbamazepine or valproate) versus appropriate comparator new drugs." | 5.12 | A randomised controlled trial examining the longer-term outcomes of standard versus new antiepileptic drugs. The SANAD trial. ( Appleton, R; Baker, GA; Chadwick, DW; Doughty, J; Eaton, B; Gamble, C; Jacoby, A; Marson, AG; Shackley, P; Smith, DF; Tudur-Smith, C; Vanoli, A; Williamson, PR, 2007) |
| " Weight gain is a significant side effect of valproic acid, which has not been clearly identified pathogenetically." | 5.12 | The role of ghrelin in weight gain and growth in epileptic children using valproate. ( Akinci, A; Gungor, S; Ozerol, IH; Tabel, Y; Yologlu, S; Yücel, G, 2007) |
| " The aim of this study was to evaluate thyroid function in 78 girls taking carbamazepine (CBZ), oxcarbazepine (OXC), or valproate (VPA) monotherapy for epilepsy and after withdrawal of the treatment." | 5.11 | Thyroid function in girls with epilepsy with carbamazepine, oxcarbazepine, or valproate monotherapy and after withdrawal of medication. ( Isojärvi, JI; Knip, M; Mikkonen, K; Myllylä, VV; Pakarinen, AJ; Rättyä, J; Vainionpää, LK, 2004) |
| "In a novel double-blind trial, topiramate was compared with the investigator's choice of carbamazepine or valproate as first-line therapy in patients as young as 6 years of age with newly diagnosed epilepsy." | 5.11 | Topiramate, carbamazepine, and valproate monotherapy: double-blind comparison in children with newly diagnosed epilepsy. ( Neto, W; Wang, S; Wheless, JW, 2004) |
| "This randomized, open-label study was designed to compare the efficacy and tolerability of lamotrigine monotherapy with those of valproate and carbamazepine monotherapy in patients with epilepsy whose seizures were uncontrolled on their prestudy antiepileptic drug monotherapy." | 5.11 | Efficacy and tolerability of conversion to monotherapy with lamotrigine compared with valproate and carbamazepine in patients with epilepsy. ( Fakhoury, TA; Hammer, AE; Messenheimer, JA; Vuong, A, 2004) |
| "A dosing algorithm was used to guide the conversion of 77 patients with epilepsy (16 years of age) from valproate monotherapy through lamotrigine adjunctive therapy at 200mg daily to lamotrigine monotherapy at 500 mg daily in an open-label study comprising a lamotrigine escalation phase (8 weeks), a valproate withdrawal phase (6 weeks), and a lamotrigine monotherapy phase (4 weeks)." | 5.11 | A dosing algorithm for converting from valproate monotherapy to lamotrigine monotherapy in patients with epilepsy. ( Biton, V; Blum, D; Hammer, AE; Messenheimer, JA; Natarajan, S; Sale, ME; Vuong, A, 2005) |
| "To determine whether valproic acid [divalproex (DVP)] extended-release, administered at a higher proportionate once-daily dosage, can be safely substituted for delayed-release or sprinkle in pediatric patients with epilepsy." | 5.11 | Extended-release divalproex in child and adolescent outpatients with epilepsy. ( Jiang, P; Kernitsky, L; O'Hara, KA; Pellock, JM, 2005) |
| "Evaluation of the effectiveness of lamotrigine in a population-based cohort of epilepsy patients." | 5.11 | Effectiveness of lamotrigine in clinical practice: results of a retrospective population-based study. ( Deckers, CL; Egberts, AC; Hekster, YA; Keyser, A; Knoester, PD; Renier, WO, 2005) |
| "A significant weight gain and increase in serum leptin levels in the course of antiepileptic treatment with valproic acid (VPA) has been described in several clinical studies." | 5.10 | Increase in postprandial serum insulin levels in epileptic patients with valproic acid therapy. ( Abraham, I; Bauer, G; Hoppichler, F; Lechleitner, M; Luef, G; Trinka, E; Unterberger, I, 2002) |
| "Body mass index (BMI) and fasting serum concentrations of insulin and lipids were measured in 102 men with epilepsy who were treated with VPA, carbamazepine (CBZ), or oxcarbazepine (OXC) monotherapy." | 5.10 | Fasting serum insulin and lipid levels in men with epilepsy. ( Isojärvi, JI; Knip, M; Kotila, M; Myllylä, VV; Pakarinen, AJ; Pylvänen, V; Rättyä, J; Turkka, J, 2003) |
| "To compare topiramate (TPM) with investigator's choice of carbamazepine (CBZ) or valproate (VPA) for initial treatment in patients with newly diagnosed epilepsy." | 5.10 | Topiramate, carbamazepine and valproate monotherapy: double-blind comparison in newly diagnosed epilepsy. ( Brodie, MJ; Chadwick, DW; Mattson, RH; Neto, W; Privitera, MD; Wang, S, 2003) |
| "The authors assessed the effect of concomitant antiepileptic therapy on steady-state plasma concentrations of the new antiepileptic drug (AED) topiramate and the potential relation between topiramate plasma levels and side effects in a cohort of 116 patients with epilepsy." | 5.10 | Topiramate therapeutic monitoring in patients with epilepsy: effect of concomitant antiepileptic drugs. ( Albani, F; Avoni, P; Baruzzi, A; Contin, M; Riva, R, 2002) |
| "We studied the efficacy of felbamate (FBM) in combination with valproic acid (VPA) in 13 patients with the Lennox-Gastaut syndrome and evaluated the contribution of each drug." | 5.09 | The efficacy of felbamate as add-on therapy to valproic acid in the Lennox-Gastaut syndrome. ( Flamini, R; Gaillard, WD; Kelley, K; Ko, D; Malow, B; Reeves-Tyer, P; Siegel, H; Stertz, B; Theodore, WH, 1999) |
| "One-hundred eighty patients with partial or idiopathic generalized nonabsence epilepsy, aged 6 to 65 years, requiring initiation of treatment with carbamazepine (CBZ), valproate (VPA), phenytoin (PHT), phenobarbital (PB), or primidone (PRM) were randomly allocated to two groups according to an open, prospective parallel-group design." | 5.09 | A multicenter randomized controlled trial on the clinical impact of therapeutic drug monitoring in patients with newly diagnosed epilepsy. The Italian TDM Study Group in Epilepsy. ( Bartoli, A; Cian, P; Fattore, C; Gatti, G; Jannuzzi, G; Monaco, F; Perucca, E, 2000) |
| "5-18 yrs with intractable epilepsy and comedicated with carbamazepine or valproate." | 5.09 | Plasma and urinary serotonin and 5-HIAA in children treated with lamotrigine for intractable epilepsy. ( Jović, NJ; Majkić-Singh, N; Milovanović, DD; Mirković, D, 1999) |
| "to describe the population pharmacokinetics of lamotrigine (LTG) in developmentally disabled (DD) patients with epilepsy and (2) to determine if there is an effect of valproate (VPA) concentration on the extent of the pharmacokinetic interaction between VPA and LTG." | 5.09 | Lack of an effect of valproate concentration on lamotrigine pharmacokinetics in developmentally disabled patients with epilepsy. ( Anderson, GD; Gidal, BE; Lanning, A; Rutecki, PR; Shaw, R, 2000) |
| " The primary aim of the study was to evaluate lamotrigine add-on therapy and consecutive monotherapy in patients with epilepsy whose seizures were not controlled by carbamazepine or valproate." | 5.09 | Open study evaluating lamotrigine efficacy and safety in add-on treatment and consecutive monotherapy in patients with carbamazepine- or valproate-resistant epilepsy. ( Jozwiak, S; Terczynski, A, 2000) |
| "Lamotrigine (LTG) is one of the newer antiepileptic drugs which has been shown to have a spectrum of drug interactions (including with other epilepsy drugs) that can have a pronounced effect on LTG kinetics." | 5.09 | Clinical study of lamotrigine and valproic acid in patients with epilepsy: using a drug interaction to advantage? ( Black, AB; Lam, E; Morris, RG; Westley, IS, 2000) |
| "To compare the incidence and magnitude of change in body weight associated with lamotrigine or divalproex sodium monotherapy in patients with epilepsy." | 5.09 | Weight change associated with valproate and lamotrigine monotherapy in patients with epilepsy. ( Barrett, PS; Biton, V; Hammer, AE; Mirza, W; Montouris, G; Vuong, A, 2001) |
| "To investigate the effects of valproic acid (VPA) on renal tubular function, we examined 15 ambulatory children with epilepsy who received VPA for at least 6 months." | 5.09 | Renal tubular dysfunction in epileptic children on valproic acid therapy. ( Altunbaşak, S; Anarat, A; Burgut, HR; Yildizaş, D, 2001) |
| "We retrospectively evaluated the ability of Scatchard binding equation method to predict the unbound serum valproic acid (VPA) concentration in 37 pediatric patients with epilepsy receiving VPA monotherapy." | 5.08 | Evaluation of binding equation method for prediction of unbound serum valproic acid concentration in pediatric patients with epilepsy. ( Fujii, I; Kodama, H; Kodama, Y; Koike, Y; Kuranari, M; Takeyama, M; Yasunaga, F, 1995) |
| "We determined serum levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), and triglycerides (TGs) in 125 healthy children and in 119 children with epilepsy who had been receiving carbamazepine (58 children), phenobarbital (22 children), or valproic acid (39 children) for 7 months to 10." | 5.08 | Effects of long-term treatment with antiepileptic drugs on serum lipid levels in children with epilepsy. ( Bravo, M; Castro-Gago, M; Del Río, MC; Eirís, JM; Lojo, S; Novo, I; Pavón, P, 1995) |
| "Using a randomized parallel group study design, we compared the cognit ive effects of carbamazepine (CBZ), phenobarbital (PB), and valproate (VPA) in children with epilepsy." | 5.08 | Comparison of antiepileptic drugs on cognitive function in newly diagnosed epileptic children: a psychometric and neurophysiological study. ( Chen, YJ; Kang, WM; So, WC, 1996) |
| "This report describes the first experiences with monitoring of valproic acid pharmacokinetics in patients with epilepsy by subcutaneous microdialysis." | 5.08 | Monitoring free extracellular valproic acid by microdialysis in epileptic patients. ( Alm, C; Ekquist, B; Lundquist, B; Ståhle, L; Tomson, T, 1996) |
| "To assess the effects of carbamazepine vs valproate sodium on cognitive functioning in patients with epilepsy compared with normal control subjects." | 5.08 | Effect of valproate on cognitive functioning. Comparison with carbamazepine. The Department of Veterans Affairs Epilepsy Cooperative Study 264 Group. ( Cattanach, L; Collins, JF; Cramer, JA; Delaney, RC; Mattson, RH; Prevey, ML, 1996) |
| "Three hundred and forty seven patients with epilepsy from 54 centres across Europe not fully controlled with sodium valproate (VPA, n = 117), carbamazepine (CBZ, n = 129), phenytoin (PHT, n = 92) or phenobarbital (PB, n = 9) monotherapy were recruited into a lamotrigine (LTG) substitution study." | 5.08 | Lamotrigine substitution study: evidence for synergism with sodium valproate? 105 Study Group. ( Brodie, MJ; Yuen, AW, 1997) |
| " This paper presents an analysis of body weight data gathered during a randomized trial comparing valproate with carbamazepine in 260 children aged 4-15 years with newly-diagnosed epilepsy." | 5.08 | Weight gain with valproate or carbamazepine--a reappraisal. ( Easter, D; O'Bryan-Tear, CG; Verity, C, 1997) |
| "We have analyzed the records retrospectively and interviewed 70 adult patients attending an epilepsy clinic on VPA mono- or polytherapy followed over a median of 27 months (range 3-189), as well as 20 patients on carbamazepine (CBZ) monotherapy." | 5.08 | Weight gain in epileptic patients during treatment with valproic acid: a retrospective study. ( Corman, CL; Guberman, AH; Leung, NM, 1997) |
| "We report the results of an open trial with lamotrigine (LTG) as add-on drug in children and adolescents with refractory epilepsy and mental delay." | 5.08 | Lamotrigine as add-on drug in children and adolescents with refractory epilepsy and mental delay: an open trial. ( Coppola, G; Pascotto, A, 1997) |
| "To evaluate population pharmacokinetics and the relationship between plasma concentration and daily dose of valproic acid (VPA) in a homogeneous group of children with epilepsy." | 5.08 | Valproic acid clearance in children with epilepsy. ( López, E; Quintana, MB; Rodríguez, I; Sánchez-Alcaraz, A, 1998) |
| "The drug encorat, an analogue of valproic acid (Sun, India) was given to 16 children aged from 4 month to 5 years suffering from resistant forms of early infantile epilepsy." | 5.07 | [The enkorat treatment of infantile spasms and the Lennox-Gastaut syndrome]. ( Badalian, LO; Iskander, MB; Kharlamov, DA; Medvedev, MI; Mukhin, KIu; Temin, PA; Veselov, NK, 1994) |
| "Subjects with epilepsy (three men and seven women; age range, 20 to 39 years; weight range, 53 to 88 kg) who were previously stabilized with valproic acid, 9." | 5.07 | The effect of felbamate on valproic acid disposition. ( Graves, NM; Leppik, IE; Perhach, JL; Remmel, RP; Shumaker, RC; Wagner, ML; Ward, DL, 1994) |
| "Sixty-four new cases of childhood epilepsy were randomly assigned to either carbamazepine, phenytoin or sodium valproate, and were assessed with behavioural measures before medication and after one and six months of treatment." | 5.07 | Psychiatric aspects of epilepsy in childhood treated with carbamazepine, phenytoin or sodium valproate: a random trial. ( Berg, I; Butler, A; Ellis, M; Foster, J, 1993) |
| "Thirteen children with intractable epilepsy were treated by means of three-times-daily administration of a conventional preparation of valproic acid (C-VPA) and twice-daily administration of a new slow-release preparation of VPA (SR-VPA) with the cross-over technique." | 5.07 | A comparative clinical and pharmacokinetic study of a new slow-release versus conventional preparations of valproic acid in children with intractable epilepsy. ( Fukuyama, Y; Imaizumi, T; Izumi, T, 1992) |
| "The effects of adding vigabatrin (GVG) to the antiepileptic regimens of 16 children with refractory epilepsy have been studied." | 5.07 | Coadministration of vigabatrin and valproate in children with refractory epilepsy. ( Armijo, JA; Arteaga, R; Herranz, JL; Valdizán, EM, 1992) |
| "Sixty-four new cases of childhood epilepsy were randomly assigned to either carbamazepine, phenytoin or sodium valproate, and were assessed with cognitive tests before medication and three subsequent times over a year." | 5.07 | Cognitive impairment in new cases of epilepsy randomly assigned to carbamazepine, phenytoin and sodium valproate. ( Berg, I; Butler, R; Forsythe, I; McGuire, R, 1991) |
| "Taltrimide was compared with valproate and placebo in 17 patients with intractable epilepsy being on carbamazepine monotherapy." | 5.06 | A controlled study with taltrimide and sodium valproate: valproate effective in partial epilepsy. ( Allonen, H; Iivanainen, M; Neuvonen, PJ; Parantainen, J; Tamminen, M; Tokola, O; Waltimo, O, 1990) |
| " All the patients had epilepsy that had previously been untreated, and had been randomly assigned to receive carbamazepine, phenytoin, or sodium valproate." | 5.06 | Withdrawal of anticonvulsant drugs in patients free of seizures for two years. A prospective study. ( Callaghan, N; Garrett, A; Goggin, T, 1988) |
| "A prospective, double-blind, placebo-controlled investigation of possible withdrawal symptoms from phenytoin, carbamazepine and sodium valproate is reported in patients with active epilepsy, on combination therapy." | 5.06 | Withdrawal symptoms from phenytoin, carbamazepine and sodium valproate. ( Duncan, JS; Shorvon, SD; Trimble, MR, 1988) |
| "Long-term use of valproic acid in treating children with epilepsy can lead to a reduction in 25-OH-VitD and BMD." | 5.05 | Effects of valproic acid on skeletal metabolism in children with epilepsy: a systematic evaluation and meta-analysis based on 14 studies. ( Biaoxue, R; Chunyan, W; Min, L, 2020) |
| "The discovery of the anticonvulsant properties of valproic acid and the development of valproic acid/valproate to market authorization for specific epilepsy types and syndromes, as well as their repurposing for other indications, are illustrative examples of both the strengths and weaknesses of drug development strategies." | 5.05 | Lessons learned from the discovery of sodium valproate and what has this meant to future drug discovery efforts? ( Janković, SM; Janković, SV, 2020) |
| " The study included a total of 183 pediatric epilepsy patients, aged 15 months-16 years, comprising 114 patients treated with valproic acid, 69 patients treated with phenobarbital, and 151 age-matched healthy volunteers as the control group." | 5.05 | The effect of antiepileptic drugs on thyroid hormonal function: valproic acid and phenobarbital. ( Güngör, O; Özkaya, AK; Temiz, F, 2020) |
| "Eighty-eight patients with the onset of epilepsy in adult life were randomly allocated to treatment with sodium valproate (600 mg/day), or phenytoin (300 mg/day), and followed up for at least 12 months." | 5.05 | A comparison of phenytoin and valproate in previously untreated adult epileptic patients. ( Chadwick, DW; Rawlins, MD; Turnbull, DM; Weightman, D, 1982) |
| "We evaluated valproic acid (VPA) for 6 months as therapy for uncontrolled seizures in 100 children, 38 with partial and 62 with generalized epilepsy." | 5.05 | Treatment of childhood epilepsy with valproic acid: results of the first 100 patients in a 6-month trial. ( Couri, D; Sherard, ES; Steiman, GS, 1980) |
| "Valproic acid, a new anticonvulsant, is most effective in absence seizures (simple and complex), but it has produced improvement in tonicclonic seizures, mixed absence with tonic-clonic seizures, and myoclonic epilepsy." | 5.04 | Valproic acid (Depakene). A new anticonvulsant agent. ( Lewis, JR, 1978) |
| "We conducted this meta-analysis to evaluate effects of second-generation anti-epileptic drugs (AEDs; levetiracetam, lamotrigine) compared to first-generation AEDs (valproic acid, carbamazepine) on bone metabolism in epilepsy patients." | 5.01 | Effects of Second-Generation Antiepileptic Drugs Compared to First-Generation Antiepileptic Drugs on Bone Metabolism in Patients with Epilepsy: A Meta-Analysis. ( Chen, Y; Fu, J; Li, J; Peng, L; Tao, T, 2019) |
| "Valproic acid (VPA) as a widely used primary medication in the treatment of epilepsy is associated with reversible or irreversible hepatotoxicity." | 5.01 | Valproic Acid and the Liver Injury in Patients with Epilepsy: An Update. ( Chen, F; Guo, HL; Hu, YH; Jing, X; Lu, XP; Ni, MM; Qiu, JC; Sun, JY; Wang, T; Xu, ZJ, 2019) |
| "We systematically reviewed studies to provide current evidence about the incidence and risk of alopecia in patients undergoing valproic acid (VPA) therapy." | 5.01 | Risk of valproic acid-related alopecia: A systematic review and meta-analysis. ( Liu, L; Wang, H; Wang, X; Xu, D; Zhu, L, 2019) |
| "Valproic acid (VPA) is frequently used in the treatment of epilepsy." | 5.01 | CPS1 T1405N polymorphism, HDL cholesterol, homocysteine and renal function are risk factors of VPA induced hyperammonemia among epilepsy patients. ( Chen, D; Chen, L; Chen, P; Gao, X; Li, C; Li, H; Li, Y; Tian, Q; Tian, X; Wen, J; Yang, H; Zhang, M, 2019) |
| " The point estimates of carbamazepine and lamotrigine efficacy showed their superiority with respect to all comparator antiepileptic drugs for the treatment of newly diagnosed focal epilepsy." | 4.98 | Comparative efficacy of antiepileptic drugs in children and adolescents: A network meta-analysis. ( Crescioli, G; De Masi, S; Guerrini, R; Ilvento, L; Lucenteforte, E; McGreevy, KS; Mugelli, A; Pugi, A; Rosati, A; Virgili, G, 2018) |
| "Lamotrigine is used in pregnancy to control epilepsy and mood disorders." | 4.95 | Pregnancy Outcomes Following In Utero Exposure to Lamotrigine: A Systematic Review and Meta-Analysis. ( Adams-Webber, T; Barzilay, E; Leibson, T; Nulman, I; Pariente, G; Shulman, T, 2017) |
| " Oxcarbazepine and lamotrigine were associated with increased occurrence of autism." | 4.95 | Comparative safety of antiepileptic drugs for neurological development in children exposed during pregnancy and breast feeding: a systematic review and network meta-analysis. ( Cogo, E; D'Souza, J; Finkelstein, Y; Hemmelgarn, BR; Hutton, B; Kealey, R; MacDonald, H; Reynen, E; Rios, P; Soobiah, C; Straus, SE; Thavorn, K; Tricco, AC; Veroniki, AA; Yazdi, F, 2017) |
| "Valproic acid is an anticonvulsant and mood-stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder." | 4.95 | The pharmacogenomics of valproic acid. ( Chen, XP; Li, HL; Luo, J; Shi, LH; Zhang, ZL; Zhu, MM, 2017) |
| " Antiepileptic drugs (AED) such as phenytoin are often used in clinical practice with the hopes of preventing post-traumatic epilepsy." | 4.91 | Pharmacological treatments for preventing epilepsy following traumatic head injury. ( Abel, H; Campbell, LA; Pohlmann-Eden, B; Thompson, K, 2015) |
| "To determine whether valproate (VPA) monotherapy influences homocysteine metabolism in patients with epilepsy." | 4.90 | Increased homocysteine levels in valproate-treated patients with epilepsy: a meta-analysis. ( Chen, Y; Chen, Z; Fang, Z; Ni, G; Qin, J; Zhou, J; Zhou, L, 2014) |
| "Valproic acid is an effective first line drug for the treatment of epilepsy." | 4.90 | Valproic acid and fatalities in children: a review of individual case safety reports in VigiBase. ( Choonara, I; Edwards, IR; Star, K, 2014) |
| "The developmental quotient (DQ) was lower in children exposed to carbamazepine (CBZ) (n = 50) than in children born to women without epilepsy (n = 79); mean difference (MD) of -5." | 4.90 | Treatment for epilepsy in pregnancy: neurodevelopmental outcomes in the child. ( Adab, N; Bromley, R; Greenhalgh, J; Marson, AG; McKay, AJ; Sanniti, A; Tudur Smith, C; Weston, J, 2014) |
| "Valproic acid is a widely-used first-generation antiepileptic drug, prescribed predominantly in epilepsy and psychiatric disorders." | 4.89 | Adverse drug reactions induced by valproic acid. ( Nanau, RM; Neuman, MG, 2013) |
| " VPA-induced weight gain seems to be associated with many metabolic disturbances; the most frequent are hyperinsulinemia and insulin resistance, hyperleptinemia and leptin resistance." | 4.89 | Metabolic and endocrine effects of valproic acid chronic treatment. ( Belcastro, V; D'Egidio, C; Striano, P; Verrotti, A, 2013) |
| "In this systematic review we present information relating to the effectiveness and safety of the following interventions: monotherapy using carbamazepine, gabapentin, lamotrigine, levetiracetam, phenobarbital, phenytoin, sodium valproate, or topiramate; addition of second-line drugs (lamotrigine or levetiracetam) for drug-resistant epilepsy; and hemispherectomy for drug-resistant epilepsy." | 4.88 | Epilepsy (generalised). ( Maguire, M; Marson, AG; Ramaratnam, S, 2012) |
| "In the last years, a growing body of literature indicates an association between valproic acid therapy and weight gain." | 4.87 | Weight gain following treatment with valproic acid: pathogenetic mechanisms and clinical implications. ( Chiarelli, F; Coppola, G; D'Egidio, C; Mohn, A; Verrotti, A, 2011) |
| "In this systematic review we present information relating to the effectiveness and safety of the following interventions: monotherapy using carbamazepine, gabapentin, lamotrigine, levetiracetam, phenobarbital, phenytoin, sodium valproate, or topiramate; addition of second-line drugs (lamotrigine or levetiracetam) for drug-resistant epilepsy; and hemispherectomy for drug-resistant epilepsy." | 4.86 | Epilepsy (generalised). ( Maguire, M; Marson, AG; Ramaratnam, S, 2010) |
| "Valproic acid (VPA), a widely used antiepileptic drug, has broad-spectrum activity against both generalized and partial epilepsy." | 4.85 | Valproate-induced insulin resistance and obesity in children. ( Chiarelli, F; la Torre, R; Mohn, A; Trotta, D; Verrotti, A, 2009) |
| " The present study aims to determine the distribution pattern of UGT1A6 and UGT2B7 gene polymorphism and its possible impact on the metabolism of valproic acid (VPA) and carbamazepine (CBZ) in patients with epilepsy from Khyber Pakhtunkhwa region of Pakistan." | 4.84 | Distribution pattern of UGT1A6 and UGT2B7 gene polymorphism and its impact on the pharmacokinetics of valproic acid and carbamazepine: Prospective genetic association study conducted in Pakistani patients with epilepsy. ( Ali, N; Almarshad, F; Alshahrani, AM; Jamil, A; Saleh Faisal, M, 2024) |
| "This review analyses the concept of extended-release (ER) formulations in epilepsy and evaluates ER formulations of carbamazepine, valproic acid and a modified-release (MR) formulation of oxcarbazepine." | 4.84 | Extended-release formulations for the treatment of epilepsy. ( Bialer, M, 2007) |
| "Valproic acid (2-n-propylpentanoic acid, VPA) is well-established as a mood-stabilizer for bipolar disorder, in addition to its application as a treatment in neurological disorders such as epilepsy, migraine headaches, and chronic neuropathic pain." | 4.84 | Valproate and neuroendocrine changes in relation to women treated for epilepsy and bipolar disorder: a review. ( Rasgon, NL; Reynolds, MF; Sisk, EC, 2007) |
| "At present there are three compounds in clinical trials in patients with epilepsy that can be regarded as second-generation VPA: valproyl glycinamide, 3-methylbutanamide or isovaleramide and SPD421 (DP-VPA)." | 4.82 | New CNS-active drugs which are second-generation valproic acid: can they lead to the development of a magic bullet? ( Bialer, M; Isoherranen, N; Yagen, B, 2003) |
| "The author reports one case of pseudocyst of the pancreas, an uncommon disorder in children, secondary to pancreatitis in a 9-year-old girl treated with valproic acid for epilepsy." | 4.82 | Pancreatic pseudocyst caused by valproic acid: case report and review of the literature. ( Hernández, F; Queizán, A; Rivas, S, 2003) |
| "Valproic acid (VPA) is a commonly prescribed medication approved for use in the United States for epilepsy, migraine, and bipolar disorder." | 4.82 | Acute pancreatitis in children from Valproic acid: case series and review. ( Feldman-Winter, LB; Goldfarb, O; Grauso-Eby, NL; McAbee, GN, 2003) |
| " However, a particular association of valproate and carbamazepine with neural tube defects (NTDs)--specifically, with spina bifida aperta (SB)--has been identified." | 4.82 | Management issues for women with epilepsy: neural tube defects and folic acid supplementation. ( Yerby, MS, 2003) |
| "Valproic acid, a branched chain carboxylic acid, has a broad spectrum of action as an antiepilepsy drug." | 4.82 | Divalproex and epilepsy. ( Willmore, LJ, 2003) |
| "To correlate lamotrigine (LTG) serum concentrations (levels) with tolerability in patients with epilepsy." | 4.82 | Correlating lamotrigine serum concentrations with tolerability in patients with epilepsy. ( Adams, DJ; Bazil, CW; Buchsbaum, R; Du, Y; Hager, M; Hirsch, LJ; Morrell, MJ; Resor, SR; Spencer, HT; Straka, T; Weintraub, D, 2004) |
| "A 12-year-old boy developed pancreatitis, complicated by a pancreatic pseudocyst, as an adverse reaction to valproic acid (VPA) treatment for epilepsy." | 4.82 | Pancreatitis, complicated by a pancreatic pseudocyst associated with the use of valproic acid. ( Houben, ML; Stroink, H; van Dijken, PJ; Wilting, I, 2005) |
| "Shire is developing DP-VPA, a prodrug of valproic acid (VPA) licensed from D-Pharm, for the potential treatment of severe forms of epilepsy, including status epilepticus, acute repetitive seizures in children and possibly manic depression and migraine [242649], [385958]; the drug is also being developed for bipolar disorder and migraine prophylaxis [385862]." | 4.81 | DP-VPA D-Pharm. ( Labiner, DM, 2002) |
| " Intermittent diazepam prophylaxis at times of fever may or may not reduce the recurrence rate significantly, but there is no data to suggest that it improves the long-term outcome, as compared with short-term seizure control, in terms of IQ, cognition, academic progress, motor control, and subsequent epilepsy." | 4.81 | [Febrile convulsions, Treatment and prognosis]. ( Knudsen, FU, 2001) |
| "To provide an overview of the evidence comparing carbamazepine (CBZ) and valproate (VPA) monotherapy for epilepsy, investigating whether existing data support the current practice of preferring CBZ for partial-onset and VPA for generalized-onset seizures." | 4.81 | Carbamazepine versus valproate monotherapy for epilepsy: a meta-analysis. ( Chadwick, DW; Clough, H; Hutton, JL; Marson, AG; Williamson, PR, 2002) |
| "We systematically reviewed and analyzed published and unpublished cases of Stevens-Johnson syndrome (SJS), or toxic epidermal necrolysis (TEN) associated with lamotrigine (LTG) therapy to identify characteristics of these reactions." | 4.80 | Lamotrigine-induced severe cutaneous adverse reactions. ( Schlienger, RG; Shapiro, LE; Shear, NH, 1998) |
| "Carbamazepine and valproate are drugs of first choice for epilepsy." | 4.80 | Carbamazepine versus valproate monotherapy for epilepsy. ( Chadwick, DW; Clough, HE; Hutton, JL; Marson, AG; Williamson, PR, 2000) |
| "The major established drugs used in the management of epilepsy are carbamazepine, valproic acid, phenytoin, phenobarbital, primidone, ethosuximide and benzodiazepine drugs." | 4.79 | Established antiepileptic drugs. ( Perucca, E, 1996) |
| "Trial reports on carbamazepine or valproate monotherapy (Medline-search), and data from the Nijmegen Epilepsy Research Group were analyzed." | 4.79 | Adverse effects in epilepsy therapy. Wait and see or go for it? ( Deckers, CL; Hekster, YA; Keyser, A; Lammers, MW; Meinardi, H; Renier, WO, 1997) |
| "This article provides an analysis of the degree of agreement between in vivo interaction studies performed in patients with epilepsy and healthy individuals, and in vitro studies which identified the cytochromes P450 (CYP) inhibited by felbamate and those involved in its metabolism." | 4.79 | Pharmacokinetic interactions with felbamate. In vitro-in vivo correlation. ( Banfield, CR; Glue, P; Levy, RH; Mather, GG; Perhach, JL; Racha, JK, 1997) |
| "We reported a case of acute pancreatitis occurring during administration of valproic acid for epilepsy." | 4.78 | [A case of acute pancreatitis during administration of valproic acid]. ( Ito, S; Kobayashi, K; Kuniya, T; Mimasu, S; Momota, T, 1993) |
| "An 11 year-old epileptic boy, treated with valproic acid developed after 11 months on therapy a severe acute pancreatitis." | 4.78 | [Acute pancreatitis and valproic acid]. ( Bovier Lapierre, M; Jalaguier, E; Kayemba Kay's Kabangu, S, 1991) |
| " Ethosuximide, valproic acid and clonazepam are used primarily in absence epilepsy." | 4.77 | Mechanisms of anticonvulsant drug action. II. Drugs primarily used for absence epilepsy. ( Browning, RA; Faingold, CL, 1987) |
| "Valproic acid use during pregnancy results in an absolute risk for spina bifida of 1-2%." | 4.77 | Teratogen update: valproic acid. ( Lammer, EJ; Oakley, GP; Sever, LE, 1987) |
| "Valproic acid, a new type of antiepileptic drug, has developed into one of the drugs of first choice in all types of epilepsy with the exception of infantile spasms and partial seizures." | 4.76 | Therapeutic monitoring of valproic acid. ( Schobben, F; van der Kleijn, E; Vree, TB, 1980) |
| "Resistance to valproic acid (VPA) is a major challenge for epilepsy treatment." | 4.31 | Overexpression of Homer1b/c induces valproic acid resistance in epilepsy. ( Li, Y; Li, Z; Lu, J; Wang, G; Wang, Y, 2023) |
| "Valproic acid (VPA)-induced hyperammonemia (HA) is a rare adverse effect reported even at therapeutic VPA levels." | 4.31 | Valproic acid-induced hyperammonemia in neuropsychiatric disorders: a 2-year clinical survey. ( Aghamollaii, V; Ghayyem, H; Hassani, M; Hosseini, H; Mayeli, M; Shafie, M; Shakiba, A, 2023) |
| "Valproic acid (VPA) is a classic medication for several types of epilepsy and mood disorders, and some of its effectiveness and toxicity is associated with metabolites." | 4.31 | Determination of valproic acid and its six metabolites in human serum using LC-MS/MS and application to interaction with carbapenems in epileptic patients. ( Chen, R; Dong, L; Hu, N; Jiang, Y; Jiang, Z; Ling, J; Yang, X; Zou, S, 2023) |
| "Valproic acid is an effective mood stabilizer, registered for the treatment of bipolar disorder and epilepsy." | 4.31 | [A severe, reversible encephalopathy after prolonged use of valproic acid]. ( Bloemkolk, D; Gerritse, FL; Rundervoort, RS; van Haaren, PCF, 2023) |
| "To investigate the efficacy and mechanisms of Dingxian pill combined with valproic acid (VPA) on pentylenetetrazol-induced chronical epilepsy in rats." | 4.31 | Efficacy and mechanisms of Dingxian pill combined with valproic acid on pentylenetetrazol-induced chronic epilepsy in rats. ( Dongxiao, QU; Guoyi, LI; Jie, T; Jiwei, C; Liji, C; Limin, Z; Qian, X; Yiqin, GE; Yonghua, X; Yudan, Z, 2023) |
| "To investigate the antiseizure medication (ASM) doses required to achieve seizure freedom and their correlation with the World Health Organization's defined daily doses (DDDs) in patients aged 16 years or older with newly diagnosed epilepsy." | 4.31 | Prescribed antiseizure medication doses and their relation to defined daily doses for achieving seizure freedom in newly diagnosed patients with epilepsy. ( Hersi, H; Peltola, J; Raitanen, J; Saarinen, JT, 2023) |
| "Findings from this explorative study strengthen the evidence for the warning against the use of valproate in pregnancy and raise concern of risks of specific psychiatric disorders associated with topiramate and levetiracetam." | 4.31 | Prenatal Exposure to Antiseizure Medication and Incidence of Childhood- and Adolescence-Onset Psychiatric Disorders. ( Alvestad, S; Bjørk, MH; Christensen, J; Cohen, JM; Dreier, JW; Furu, K; Gissler, M; Igland, J; Leinonen, MK; Sun, Y; Tomson, T; Zoega, H, 2023) |
| "We present a case of a 29-year-old female with a history of epilepsy who was admitted for convulsive status epilepticus (CSE), which was controlled by intravenous VPA, as well as oral VPA and phenytoin." | 4.31 | Valproate-related hyperammonemic encephalopathy with generalized suppression EEG: a case report. ( Liu, X; Peng, X, 2023) |
| "Valproic acid (VPA) is a relatively safe drug widely used for the treatment of epileptic seizures and mania in bipolar disorder, as well as the prevention of migraine headaches." | 4.31 | Acute pancreatitis during valproic acid administration in a patient with vascular dementia, epileptic seizures, and psychiatric symptoms: a case report. ( Harada, M; Hashimoto, R; Igata, R; Ikenouchi, A; Isomoto, N; Konishi, Y; Okamoto, N; Shinkai, T; Yanaga, M; Yoshimura, R, 2023) |
| "A prospective longitudinal study was conducted to assess the Apo B100/A1 ratio as a marker of cardiovascular risk in children with epilepsy aged 5-14 years on long-term anti-seizure medication monotherapy with either sodium valproate, oxcarbazepine, or levetiracetam." | 4.31 | Change in Apo B100/A1 Ratio in Children With Epilepsy on Monotherapy With Sodium Valproate, Oxcarbazepine or Levetiracetam. ( Dhama, A; Kaushik, JS; Lekhwani, S, 2023) |
| "Dose-adjusted lamotrigine troughs in epilepsy patients with variant UGT2B7 -161C > T or UGT1A4*3 c." | 4.31 | Bearing variant alleles at uridine glucuronosyltransferase polymorphisms UGT2B7 -161C > T (rs7668258) or UGT1A4*3 c.142 T > G (rs2011425) has no relevant consequences for lamotrigine troughs in adults with epilepsy. ( Božina, N; Domjanović, IK; Gadže, ŽP; Ganoci, L; Lovrić, M; Romić, ZČ; Šimičević, L; Sporiš, IŠ; Trkulja, V, 2023) |
| " The aim of this study was to explore the association of SCN1A polymorphisms with efficacy and adverse drug reactions (ADRs) related to valproic acid (VPA) among Chinese children with epilepsy." | 4.31 | SCN1A Polymorphisms and Haplotypes Are Associated With Valproic Acid Treatment Outcomes in Chinese Children With Epilepsy. ( Fan, X; Guo, H; He, Y; Li, W; Lu, J; Shen, X; Xia, H; Zhang, J; Zhu, J, 2023) |
| "Valproic acid (VPA) has long been the most widely used antiepileptic drug (AED) for the treatment of epilepsy, bipolar psychiatric disorders, and migraine." | 4.31 | Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo. ( Chalmel, F; Costet, N; Desdoits-Lethimonier, C; Evrard, B; Hug, E; Jégou, B; Kugathas, I; Lavoué, V; Lesné, L; Mazaud-Guittot, S; Raffenne, L; Toupin, M, 2023) |
| "This study revealed the higher risk of cardiac arrhythmias persists long term in people with epilepsy, especially among those using carbamazepine and valproic acid." | 4.31 | Epilepsy and long-term risk of arrhythmias. ( Cai, J; Feng, Z; Huang, P; Liu, P; Lu, J; Lu, Y; Tang, H; Wang, J; Yang, G; Yang, Y; Yu, Q; Yuan, H, 2023) |
| "Use of valproate and carbamazepine decreased progressively, use of lamotrigine remained relatively static, and the use of levetiracetam increased progressively, whereas the use of topiramate first increased and then fell again, associated with a temporary increase in malformation-associated pregnancy rate." | 4.31 | Changes over 24 years in a pregnancy register - Teratogenicity and epileptic seizure control. ( Eadie, M; Graham, J; Hitchcock, A; Lander, C; O'Brien, T; Perucca, P; Vajda, F, 2023) |
| " In our case series, lamotrigine proved to be less effective and less controllable than other drugs during pregnancy." | 4.12 | [Women with epilepsy before and during pregnancy: a case series of outpatient counseling in a tertiary epilepsy center]. ( Bien, CG; Hagemann, A; Knaak, N; Müffelmann, B, 2022) |
| "Valproic acid (VPA) and levetiracetam (LEV) are used in epilepsy treatment." | 4.12 | Successful Treatment of Symptomatic Epilepsy with Oral Valproic Acid and Levetiracetam in a Patient with Short-bowel Syndrome. ( Hayashi, M; Iijima, A; Isozaki, R; Kurishima, A; Shimozato, R; Shioda, T, 2022) |
| "Valproic acid (VPA) is used for the treatment of epilepsy and bipolar disorder (BD)." | 4.12 | Long-term use of valproic acid reduced mortality in bipolar disorder patients in a Taiwanese population: An association analysis using the national health insurance research database (NHIRD). ( Hsieh, TC; Lin, CC; Wu, LS, 2022) |
| "To assess knowledge among neurologists in Sweden and Norway on the restrictions issued by the European Medicines Agency (EMA) regarding use of valproic acid (VPA) to female patients of childbearing potential, their use of the pregnancy prevention programme and their VPA prescription habits." | 4.12 | Valproate Restrictions in Sweden and Norway: Online survey suggests implementation deficit. ( Sveberg, L; Taubøll, E; Tomson, T; Zelano, J, 2022) |
| " In most Australian women starting therapy for epilepsy initiating treatment with levetiracetam monotherapy may offer the best chance of such a desirable outcome to a future pregnancy, yet to be confirmed." | 4.12 | Achieving neurologically desirable outcomes to pregnancy in women with epilepsy. ( Eadie, MJ; Graham, JE; Hitchcock, AE; Lander, CM; O'Brien, TJ; Perucca, P; Vajda, FJE, 2022) |
| "In a nation-wide population-based longitudinal register linkage study for the first time 1) to investigate long-term response to lithium in patients with bipolar disorder with and without comorbid epilepsy, and 2) within patients with bipolar disorder and comorbid epilepsy to compare differences in responses between lithium, valproate and lamotrigine." | 4.12 | Response to lithium and anticonvulsants among patients with bipolar disorder with and without comorbid epilepsy - A nation-wide population-based longitudinal study. ( Budtz-Jørgensen, E; Gerds, T; Kessing, LV; Ziersen, SC, 2022) |
| " Here we examine the effects of valproic acid (VA) plus 4-phenylbutyric acid (4-PBA) on abnormal electrical brain activity, ER stress and apoptosis in acute seizures induced by pentylenetetrazole (PTZ)." | 4.12 | 4-Phenylbutyric Acid Plus Valproic Acid Exhibits the Therapeutic and Neuroprotective Effects in Acute Seizures Induced by Pentylenetetrazole. ( Amanvermez, R; Arslan, G; Gün, S; Rzayev, E; Tiryaki, ES, 2022) |
| "AbstractThe aim of this study was to explore the effect of lamotrigine (LTG) on blood ammonia level in patients with epilepsy and identify risk factors affecting blood ammonia level." | 4.12 | Risk factors of elevated blood ammonia level in epilepsy patients treated with lamotrigine. ( Chen, J; Chen, X; Chen, Y; Miao, J; Wang, R; Zeng, J; Zhuang, X, 2022) |
| " Consecutive adolescent patients with epilepsy aged 11-17 years with partial or generalized seizures, treated with either levetiracetam or valproic acid for at least 6 months, and healthy controls were recruited." | 4.12 | Irritability and its relationship with psychosocial symptoms and quality of life in adolescents with epilepsy receiving levetiracetam therapy: A case-control study. ( Tekin, E; Tekin, U; Uçar, HN, 2022) |
| "The present study identifies a significant positive association between ASM and LUTI incidence and antibiotic prescriptions in patients with epilepsy treated with pregabalin, whereas a protective effect was found for carbamazepine in women only." | 4.12 | Association between anti-seizure medication and the risk of lower urinary tract infection in patients with epilepsy. ( Ehrenberg, C; Gremke, N; Kalder, M; Kostev, K; Möller, L; Printz, M, 2022) |
| "This study aimed to explore the effect of concomitant use of Furosemide (FRS) and Valproic acid (VPA), demonstrating anti-inflammation efficacy, on epilepsy, and its underlying mechanism." | 4.12 | The effect of valproic acid and furosemide on the regulation of the inflammasome complex (NLRP1 and NLRP3 mRNA) in the brain of epileptic animal model. ( Abdolmaleki, Z; Faedmaleki, F; Samadianzakaria, A, 2022) |
| "To compare the hazard for all-cause mortality and mortality due to heart failure (HF) between valproate (VPA) and levetiracetam (LEV)/lamotrigine (LTG) users in patients aged ≥ 65 with comorbidities of epilepsy and HF." | 4.12 | The Relationship Between Valproate and Lamotrigine/Levetiracetam Use and Prognosis in Patients With Epilepsy and Heart Failure: A Danish Register-Based Study. ( Gardella, E; Kragholm, K; Liang, D; Polcwiartek, C; Sessa, M, 2022) |
| "To study the association between CYP2C19*2 (681 G > A) and UGT1A6*2 (552A > C) polymorphisms on Valproic acid (VPA)-induced weight gain in People with epilepsy (PWE)." | 4.02 | CYP2C19 & UGT1A6 genetic polymorphisms and the impact on Valproic acid-induced weight gain in people with epilepsy: Prospective genetic association study. ( Kamalanathan, S; Kesavan, R; Mani, B; Nair, PP; Narayan, SK; Sekhar, A, 2021) |
| "A retrospective chart review conducted at King Abdulaziz University Hospital, Jeddah, Kingdome of Saudi Arabia, for children below 2 years of age diagnosed with epilepsy and treated with valproic acid from January 2016 to January 2020." | 4.02 | Valproic acid for children below 2 years of age with epilepsy. ( Alfawaz, NS; Almahmudi, SM; Alrabghi, MO; Bin Mahfouz, MM; Muthaffar, OY, 2021) |
| "Children aged 1 to 12 years, diagnosed with epilepsy (generalized or focal seizures), treated with valproate (n = 40) and valproate with add-on levetiracetam (n = 40) were included." | 4.02 | Effect of valproate and add-on levetiracetam on inflammatory biomarkers in children with epilepsy. ( Gupta, R; Halder, S; Kar, R; Labh, R; Narang, M, 2021) |
| "Prenatal uptake of valproic acid (VPA) was associated with increased risk of fetal cardiac anomalies and autism spectrum disorder (ASD), but uptake of VPA is considered the only effective treatment for epilepsy and other neurological disorders." | 4.02 | Effect of Valproic Acid on Maternal - Fetal Heart Rates and Coupling in Mice on Embryonic day 15.5 (E15.5). ( Fukase, M; Kasahara, Y; Khandoker, A; Kimura, Y; Nakanishi, K; Saito, M; Suzuki, A; Widatalla, N; Yoshida, C, 2021) |
| " The aim of our study was to investigate the effects of valproic acid and carbamazepine monotherapy used in the treatment of epilepsy patients on serum adiponectin and carnitine levels." | 4.02 | The correlation between carbamazepine and valproic acid monotherapy with serum adiponectin and carnitine. ( Ceylan, M; İyigün, İ; Kızıltunç, A; Şimşek, F, 2021) |
| "The purpose of this study was to establish a protein binding model of unbound valproic acid (VPA) based on Chinese pediatric patients with epilepsy and provide a reference for clinical medication." | 4.02 | Population pharmacokinetics of unbound valproic acid in pediatric epilepsy patients in China: a protein binding model. ( Gu, X; Hu, Y; Jiao, Z; Li, Z; Ma, M; Peng, Q; Sheng, C; Yu, S; Zhou, B; Zhu, M, 2021) |
| " In the pharmacodynamic interaction study, seizures were induced using pentylenetetrazole (PTZ) (60 mg/kg, i." | 4.02 | Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats. ( Agarwal, A; Arora, R; Ganeshan N, S; Gupta, YK; Kaleekal, T; Kumar, R; Sarangi, SC, 2021) |
| " In this study, we examined the effect of both acute and chronic treatment with moclobemide on seizures and the action of first-generation antiepileptic drugs: valproate, carbamazepine, phenobarbital and phenytoin." | 4.02 | Acute and chronic treatment with moclobemide, a reversible MAO-inhibitor, potentiates the antielectroshock activity of conventional antiepileptic drugs in mice. ( Banach, M; Borowicz-Reutt, KK, 2021) |
| "Prenatal exposure to the antiepileptic drug (AED) valproic acid (VPA) is associated with an increased risk of impaired postnatal neurodevelopment, including autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD)." | 4.02 | Prenatal valproate exposure and adverse neurodevelopmental outcomes: Does sex matter? ( Anderson, A; Graham, J; Hitchcock, A; Honybun, E; Malpas, CB; O'Brien, TJ; Perucca, P; Rayner, G; Thwaites, R; Vajda, FJE, 2021) |
| " Exanthema as especially clinically relevant adverse drug event was rightly chosen for carbamazepine by 18 (8%) and for lamotrigine by 12 (5%) participants." | 4.02 | Knowledge of epilepsy among German pharmacists. ( Bertsche, A; Bertsche, T; Herziger, B; Jeschke, S; Müller, RM; Neininger, MP, 2021) |
| "We measured carnitine levels before and after pivalate-conjugated antibiotic (PCA) use in six patients with epilepsy who were prescribed valproate (VPA)." | 4.02 | Carnitine supplementation prevents carnitine deficiency caused by pivalate-conjugated antibiotics in patients with epilepsy prescribed valproate. ( Azuma, Y; Iwayama, H; Kurahashi, H; Numoto, S; Okumura, A, 2021) |
| "39 years) with epilepsy, well controlled by monotherapy with levetiracetam, valproic acid, ethosuximide, oxcarbazepine or carbamazepine and 45 age/sex-matched controls." | 4.02 | Effects of antiseizure monotherapy on visuospatial memory in pediatric age. ( Coppola, G; Di Bonaventura, C; Donadio, S; Operto, FF; Padovano, C; Pastorino, GMG; Scuoppo, C; Vivenzio, V, 2021) |
| "We explored the potential effects of genetic variations on the concentration to dose ratio (CDR) of valproic acid (VPA) in paediatric epilepsy patients." | 4.02 | Influence of ( Du, Z; Liu, M; Wang, J; Xu, H; Xu, Q; Zhao, P, 2021) |
| "Overall, serum free carnitine levels showed significant negative correlations with epilepsy duration, VPA treatment duration, daily VPA dose, and blood VPA concentration." | 4.02 | Factors associated with blood carnitine levels in adult epilepsy patients with chronic valproic acid therapy. ( Miyaoka, H; Saito, M; Takizawa, T, 2021) |
| "Although several studies have indicated that valproate (VPA) and oxcarbazepine (OXC) cause reproductive endocrine disorders and sexual dysfunction, there remains some controversy regarding these issues in males with epilepsy." | 4.02 | A Comparative Study of the Effects of Valproate and Oxcarbazepine on Sexual Function, Sperm Quality, and Sex Hormones in Males with Epilepsy. ( Chen, L; Guo, Y; Sun, H; Wu, D; Yu, L; Zhu, Q, 2021) |
| "Epilepsy patients were followed up at the Antalya Training and Research Hospital Department of Neurology, Epilepsy Outpatient Clinic who were at high risk for osteoporosis (use of valproic acid [VPA] and enzyme-inducing drugs, using any AED for over 5 years, and postmenopausal women) and were evaluated using a screening protocol." | 4.02 | Management of bone metabolism in epilepsy. ( Abidin, E; Fatma, G; Uçan Tokuç, FE; Yasemin, GB, 2021) |
| "We measured the serum-free carnitine (FC), VPA, aspartate aminotransferase, alanine aminotransferase, amylase, and ammonia levels, and the platelet count, in 69 patients with childhood-onset epilepsy treated with VPA." | 4.02 | Effects of l-carnitine supplementation in patients with childhood-onset epilepsy prescribed valproate. ( Azuma, Y; Iwayama, H; Kurahashi, H; Numoto, S; Okumura, A; Takagi, M, 2021) |
| " Importantly, the isobolographic analysis showed that a combination of AS-1 and valproic acid (VPA) at the fixed ratio of 1:1 displayed a supra-additive (synergistic) interaction against PTZ-induced seizures in mice." | 3.96 | N-Benzyl-(2,5-dioxopyrrolidin-1-yl)propanamide (AS-1) with Hybrid Structure as a Candidate for a Broad-Spectrum Antiepileptic Drug. ( Abram, M; Andres-Mach, M; Esguerra, CV; Gawel, K; Jakubiec, M; Kamiński, K; Latacz, G; Lubelska, A; Nieoczym, D; Pieróg, M; Rapacz, A; Socała, K; Szewczyk, A; Szulczyk, B; Wlaź, P; Zagaja, M; Łuszczki, JJ, 2020) |
| "The aim of the study was to investigate the risk of subclinical atherosclerosis independent from obesity and high blood lipid levels in pediatric patients with idiopathic epilepsy receiving valproic acid or levetiracetam monotherapy by evaluating carotid intima-media thickness (CIMT) and Epicardial adipose tissue thickness (EATT)." | 3.96 | Effects of valproic acid and levetiracetam monotherapy on carotid intima-media and epicardial adipose tissue thickness in non-obese children with epilepsy. ( Karatoprak, E; Tosun, O, 2020) |
| " Epilepsy-associated comorbid depression was evaluated by tail suspension test, sucrose preference test, and plasma corticosterone levels, whereas epilepsy-associated memory deficit condition was assessed by step-through paradigm, Morris water maze, and nitrite levels." | 3.96 | Exploring the ameliorative role of α7 neuronal nicotinic acetylcholine receptor modulation in epilepsy and associated comorbidities in post-PTZ-kindled mice. ( Goel, RK; Kaur, S; Sharma, NK, 2020) |
| "We sought to explore the effects of sodium valproate combined with lamotrigine on quality of life and serum inflammatory factors in patients with poststroke secondary epilepsy." | 3.96 | Effects of Sodium Valproate Combined with Lamotrigine on Quality of Life and Serum Inflammatory Factors in Patients with Poststroke Secondary Epilepsy. ( Guo, D; Hao, F; Li, X; Liu, X; Sun, J; Tang, W; Tao, S, 2020) |
| "The aim of the study was to investigate how age and genetic polymorphisms of UGT1A6 and UGT2B7 contribute to the concentrations of valproic acid (VPA) and its hepatotoxic metabolites in Chinese pediatric patients with epilepsy." | 3.96 | Impact of Age and Genotype on Serum Concentrations of Valproic Acid and Its Hepatotoxic Metabolites in Chinese Pediatric Patients With Epilepsy. ( Chen, Y; Li, G; Wang, M; Zhao, L; Zhao, M, 2020) |
| "Here, we present a multicenter series of patients with developmental and epileptic encephalopathies (DEE) and related electroclinical patterns (REP) other than Lennox-Gastaut syndrome (LGS) who were treated with rufinamide as add-on therapy." | 3.96 | Rufinamide as add-on therapy in children with epileptic encephalopathies other than Lennox-Gastaut syndrome: A study of 34 patients. ( Caraballo, RH; Espeche, A; Fasulo, L; Galichio, S; Pociecha, J; Reyes, G; Semprino, M, 2020) |
| "These findings suggest that carnitine deficiency is associated with the VPA dose and the serum VPA level in patients with bipolar disorder." | 3.96 | Association Between the Serum Carnitine Level and Ammonia and Valproic Acid Levels in Patients with Bipolar Disorder. ( Ishioka, M; Kubo, K; Miyazaki, K; Nakagami, T; Shimoda, K; Sugawara, N; Tarakita, N; Yasui-Furukori, N; Yokoyama, S, 2020) |
| "Dose individualization is essential in epilepsy treatment, especially in antiepileptic drugs that present high interindividual variability such as lamotrigine." | 3.96 | Dosing Recommendations Based on Population Pharmacokinetics of Lamotrigine in Mexican Adult Patients With Epilepsy. ( Chávez-Castillo, CE; Medellín-Garibay, SE; Milán-Segovia, RDC; Rodríguez-Leyva, I; Romano-Moreno, S, 2020) |
| "Female sex, refractoriness, and clonazepam use may be risk factors for depression after epilepsy diagnosis." | 3.96 | Factors associated with depression in people with epilepsy: a retrospective case-control analysis. ( Chang, RSK; Ho, PH; Leung, IYH; Leung, WCY, 2020) |
| "In January 2019, a new plant-derived purified cannabidiol preparation, approved by the US Food and Drug Administration, became commercially available for patients ≥2 years old with Lennox-Gastaut syndrome or Dravet syndrome." | 3.96 | Thrombocytopenia in pediatric patients on concurrent cannabidiol and valproic acid. ( Carlson, M; Dang, LT; Fedak Romanowski, EM; Joshi, SM; Leber, SM; McNamara, NA; Robertson, P; Shellhaas, RA; Smith, GC; Sturza, J; Ziobro, JM, 2020) |
| "Nocturnal enuresis is one of the side effects of valproic acid treatment, and generally underdiagnosed by clinicians." | 3.96 | Sleep Architecture in Valproate-Induced Nocturnal Enuresis in Primary School and Preschool Children. ( Abdelsalam, M; Bendary, L; Egila, H; Elsherief, M; Esmael, A, 2020) |
| "To evaluate the changes of epileptiform activity index (EAI) as a measure of the efficacy and tolerability of treatment with valproic acid (VA) in patients with newly-diagnosed generalized and focal epilepsy." | 3.96 | [Dynamics of epileptiform activity, efficacy and tolerability of valproic acid in adults and adolescents with newly-diagnosed epilepsy]. ( Karlov, VA; Kozhokaru, AB; Orlova, AS; Pushkar, TN; Vlasov, PN, 2020) |
| "Due to the narrow therapeutic window of valproic acid (VPA), grievous adverse reactions such as hepatotoxicity, nephrotoxicity may occur in patients with epilepsy for a long time." | 3.96 | Valproic acid concentration and biochemical indexes in epilepsy outpatients during monotherapy or combination therapy. ( Luo, J; Ma, H; Pan, J; Wang, C; Wang, P; Yang, X, 2020) |
| "This study was conducted to explore the influence of genetic variations on responsiveness to valproic acid (VPA) monotherapy among Chinese children with epilepsy." | 3.96 | Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children. ( Du, Z; Liu, M; Mao, J; Wang, J; Xu, H; Xu, Q; Zhao, P, 2020) |
| "The aim of this study was to evaluate the effects of valproate (VPA), lamotrigine (LTG), and levetiracetam (LEV) on bone turnover and bone mineral density (BMD) in newly diagnosed adult patients with epilepsy." | 3.96 | Effects of valproate, lamotrigine, and levetiracetam monotherapy on bone health in newly diagnosed adult patients with epilepsy. ( Guo, Y; Huang, Y; Lin, Z; Yu, L, 2020) |
| "The aim of the study was to assess whether, male patients with epilepsy, switching from valproic acid (VPA) to levetiracetam (LEV) or lamotrigine (LMG) critically improves sperm counts and parameters, increasing chance of patients' female partners to spontaneously conceive." | 3.96 | An open study of valproate in subfertile men with epilepsy. ( Georgiou, I; Kostoulas, C; Markoula, S; Siarava, E; Zikopoulos, A, 2020) |
| "Phenobarbital and sodium valproate are broad spectrum and inexpensive antiepileptic drugs that are used to treat convulsive epilepsy." | 3.91 | Efficacy of phenobarbital and sodium valproate in treating convulsive epilepsy in rural northeast China. ( Li, J; Li, N; Lin, W; Yang, D; Zhao, D, 2019) |
| " The agents tested were: alpha-lactoalbumin (ALAC), a whey protein rich in tryptophan, effective in some animal models of epilepsy and on colon/intestine inflammation, valproic acid (VPA), an effective antiepileptic drug in this seizure model, mesalazine (MSZ) an effective aminosalicylate anti-inflammatory treatment against ulcerative colitis and sodium butyrate (NaB), a short chain fatty acid (SCFA) normally produced in the intestine by gut microbiota, important in maintaining gut health and reducing gut inflammation and oxidative stress." | 3.91 | Intestinal inflammation increases convulsant activity and reduces antiepileptic drug efficacy in a mouse model of epilepsy. ( Avagliano, C; Calignano, A; Citraro, R; Constanti, A; De Caro, C; De Sarro, G; di Cesare Mannelli, L; Ghelardini, C; Leo, A; Mainardi, P; Nesci, V; Russo, E; Striano, P, 2019) |
| " A 13-year-old girl with genetically confirmed Pitt-Hopkins syndrome with uncontrolled seizures, while on treatment with levetiracetam and valproic acid, was started on perampanel, reaching seizure control." | 3.91 | Perampanel-induced hair curling in a patient with epilepsy associated with Pitt Hopkins syndrome. ( Calle-Lopez, Y; Knight, EP; Kotagal, P, 2019) |
| "A 24-year-old woman with a long-standing history of polio and a 2-year history of epilepsy developed a serious ADR after repeated exposure to oral clonazepam combined with sodium valproate that manifested as myotoxicity and elevated levels of creatine phosphokinase." | 3.91 | A serious adverse drug reaction probably induced by clonazepam: a case report of myotoxicity. ( Han, X; Wang, J, 2019) |
| " This study evaluated the efficacy of sodium valproate encapsulated in nanoparticles in pentylenetetrazole (PTZ) induced acute and kindling models of seizures in male Wistar rats." | 3.91 | Evaluation of sodium valproate loaded nanoparticles in acute and chronic pentylenetetrazole induced seizure models. ( Dinda, AK; Gupta, YK; Kottarath, SK; Meenu, M; Reeta, KH, 2019) |
| "The objective of this study was to evaluate the long-term safety, tolerability, and efficacy of cannabidiol in children with epilepsy." | 3.91 | Long-Term Safety, Tolerability, and Efficacy of Cannabidiol in Children with Refractory Epilepsy: Results from an Expanded Access Program in the US. ( Caminha Nunes, E; Cilio, MR; Oldham, MS; Rahdari, S; Sands, TT; Tilton, N, 2019) |
| "The aims of this study were to identify the influencing factors such as gender, age, dose and combinations of other antiepileptic drugs (AEDs), especially in triple combinations on the pharmacokinetic of Lamotrigine (LTG) in epilepsy patients of Northwest Chinese Han population." | 3.91 | The influence of concomitant antiepileptic drugs on lamotrigine serum concentrations in Northwest Chinese Han population with epilepsy. ( Han, X; Huang, J; Lv, J; Ma, L; Nie, X; Peng, L; Wang, J; Xia, L; Zan, X, 2019) |
| "Irritability has been described as a frequent adverse event in patients affected by epilepsy and treated with perampanel (PER), levetiracetam (LEV), and less frequently with valproic acid (VPA)." | 3.91 | Preliminary evidence about irritability in patients with epilepsy treated by perampanel as first add-on therapy compared to levetiracetam and valproic acid. ( Assogna, M; Canevini, MP; Izzi, F; Liguori, C; Mercuri, NB; Placidi, F; Turner, K, 2019) |
| "There is a large inter-individual variation in the efficacy of valproic acid (VPA) against epilepsy." | 3.91 | SCN1A and SCN2A polymorphisms are associated with response to valproic acid in Chinese epilepsy patients. ( Chen, X; Li, H; Lin, C; Luo, J; Shi, L; Wen, Z; Zhang, Z; Zhu, M, 2019) |
| "This study measured the serum carnitine levels in patients with epilepsy and determined the factors contributing to low carnitine levels." | 3.91 | Serum carnitine levels of children with epilepsy: Related factors including valproate. ( Iwayama, H; Kurahashi, H; Numoto, S; Okumura, A, 2019) |
| "Valproic acid (VPA) is used as one of the first-line antiepileptic drugs to control seizure in epilepsy patients." | 3.91 | Correlation of MCT1 and ABCC2 gene polymorphisms with valproic acid resistance in patients with epilepsy on valproic acid monotherapy. ( Chen, J; Chen, Z; Huang, M; Li, H; Qin, J; Ruan, H; Su, Q; Wang, X; Zhou, L; Zhou, S; Zhou, Y, 2019) |
| "Valproic acid (VPA) is currently one of the four most often prescribed antiepileptic drugs (AEDs) in pregnancy." | 3.91 | Valproic acid concentrations in nursing mothers, mature milk, and breastfed infants in monotherapy and combination therapy. ( Brozmanova, H; Grundmann, M; Kacirova, I, 2019) |
| " Pentylenetetrazole- (PTZ) and pilocarpine-induced seizures are well-established models of human epilepsy." | 3.91 | The effect of co-administration of pentylenetetrazole with pilocarpine: New modified PTZ models of kindling and seizure. ( Jand, A; Mousavi-Hasanzadeh, M; Palizvan, MR; Rezaeian-Varmaziar, H; Shafaat, O, 2019) |
| "Valproic acid has a long-standing reputation of effectively treating the symptoms of not only epilepsy but also psychiatric conditions." | 3.91 | Valproic acid potently inhibits interictal-like epileptiform activity in prefrontal cortex pyramidal neurons. ( Nurowska, E; Pasierski, M; Szulczyk, B, 2019) |
| "Our aim was to investigate any adverse effects of long-term valproic acid (VPA) therapy on bone biochemical markers in ambulatory children and adolescents with epilepsy, and the possible benefits of vitamin D supplementation on the same markers." | 3.91 | Vitamin D supplementation and bone markers in ambulatory children on long-term valproic acid therapy. A prospective interventional study. ( Challa, A; Cholevas, V; Nakou, I; Papassava, M; Siomou, E; Tzoufi, M, 2019) |
| " Reported is a 16-year-old man with intractable epilepsy and an 11-year history of chronic hyponatraemia (126-135 mEq/L) due to valproic acid induced syndrome of inappropriate antidiuresis who sustained low-impact fragility fractures and had evidence of osteopaenia on both X-ray and dual energy X-ray absorptiometry (DEXA)." | 3.91 | Fragility fractures and reversible osteopaenia due to chronic hyponatraemia in an adolescent male. ( Ayus, JC; Moritz, ML; Patel, M, 2019) |
| "The aim of this study is to evaluate if valproate (VPA) and levetiracetam (LEV) as monotherapy are associated with vitamin D deficiency among children with epilepsy." | 3.88 | Vitamin D deficiency in children with epilepsy taking valproate and levetiracetam as monotherapy. ( Aguilera-Albesa, S; Durá-Travé, T; Gallinas-Victoriano, F; Malumbres-Chacón, M; Moreno-Gónzalez, P; Yoldi-Petri, ME, 2018) |
| "The aim of this study was to investigate the effect of carbamazepine (CBZ) and sodium valproate (VPA) monotherapy on sexual functions, sex hormones, and semen analysis and quality in male patients with epilepsy." | 3.88 | Evaluation of sex hormones and sperm parameters in male epileptic patients. ( Colak, A; Köse, C; Ocek, L; Sarıteke, A; Tarhan, H; Uludağ, FI; Zorlu, F; Zorlu, Y, 2018) |
| "To assess the effect of monotherapy with Carbamazepine (CBZ) and Sodium valproate (VPA) on serum 25-OH Vitamin D levels in children with epilepsy compared to controls." | 3.88 | Vitamin D Deficiency in Ambulant Children on Carbamazepine or Sodium Valproate Monotherapy. ( Devadathan, K; Mohammed Kunju, PA; Muthubeevi, S; Pillai, JP; Sasidharan, B; Sreedharan, M; Vasumathy Amma, MA, 2018) |
| "A total of 304 patients with epilepsy, aged 18-70 years, were divided into a lamotrigine monotherapy group and groups receiving lamotrigine with AEDs that act as enzyme inducers, enzyme inhibitors, or both." | 3.88 | Effect of antiepileptic drug comedication on lamotrigine concentrations. ( Božina, N; Čajić, I; Klarica Domjanović, I; Lovrić, M; Petelin Gadže, Ž, 2018) |
| "To explore the incidence and independent risk-factors of secondary carnitine deficiency in Chinese children with epilepsy on valproate monotherapy." | 3.88 | Carnitine Deficiency in Chinese Children with Epilepsy on Valproate Monotherapy. ( Hong, J; Qiliang, L; Wenqi, S, 2018) |
| " The frequency of number of seizures/week was higher in the carbamazepine cohort compared to valproic acid cohort." | 3.88 | Carbamazepine Verses Valproic Acid as Monotherapy in Epileptic Patients. ( Ali, N; Nazish, H; Shakir, S, 2018) |
| "In the study, the effect of valproic acid on serum free/acylcarnitine levels and left ventricular systolic function in pediatric patients with idiopathic epilepsy receiving valproic acid was investigated." | 3.88 | Evaluation ofserum free carnitine/acylcarnitine levels and left ventricular systolic functions in children with idiopathic epilepsy receiving valproic acid. ( Celik, H; Ince, H; Kulhas Celik, I; Sungur, M; Tasdemir, HA, 2018) |
| "Adults with epilepsy on lamotrigine monotherapy (n = 131) or lamotrigine + valproate treatment (n = 74) were genotyped and steady-state lamotrigine and valproate morning troughs were determined as a part of routine therapeutic drug monitoring." | 3.88 | Interaction between ABCG2 421C>A polymorphism and valproate in their effects on steady-state disposition of lamotrigine in adults with epilepsy. ( Božina, N; Čajić, I; Ganoci, L; Klarica Domjanović, I; Lovrić, M; Petelin-Gadže, Ž; Trkulja, V, 2018) |
| "This study was aimed at identifying genetic and non-genetic risk factors for valproic acid (VPA)-induced hyperammonaemia in Chinese paediatric patients with epilepsy." | 3.88 | Risk Factors for Valproic Acid-induced Hyperammonaemia in Chinese Paediatric Patients with Epilepsy. ( Li, X; Zhang, T; Zhao, L; Zhu, X, 2018) |
| "Evaluation of biochemical derangements related to metabolic syndrome in epileptic patients on treatment with Valproic acid." | 3.88 | Biochemical derangements related to metabolic syndrome in epileptic patients on treatment with valproic acid. ( Bobby, Z; Nisha, Y; Wadwekar, V, 2018) |
| "The purpose of this study was to determine the effect of lamotrigine (LTG) and levetiracetam (LEV) as mono- and polytherapy on biochemical markers of bone turnover and bone mineral density in Egyptian adult patients with epilepsy." | 3.88 | Levetiracetam and lamotrigine effects as mono- and polytherapy on bone mineral density in epileptic patients. ( Akef, GH; Allah, HMS; El-Haggar, SM; Mostafa, TM, 2018) |
| "Valproic acid (VPA) provides a common treatment for both epilepsy and bipolar disorder; however, common cellular mechanisms relating to both disorders have yet to be proposed." | 3.88 | Diacylglycerol kinase (DGKA) regulates the effect of the epilepsy and bipolar disorder treatment valproic acid in ( Kelly, E; Sharma, D; Wilkinson, CJ; Williams, RSB, 2018) |
| "This 13-year-old girl with autism and intractable epilepsy experienced increased seizures; her valproic acid dose was increased and other antiepileptic drugs were administered." | 3.85 | Burst Suppression Pattern on Electroencephalogram Secondary to Valproic Acid-Induced Hyperammonemic Encephalopathy. ( Cherian, KA; Legatt, AD, 2017) |
| "Because the pharmacokinetic evaluation of valproic acid (VPA) based on total drug concentration may be misleading in patients with hypoalbuminemia as a result of saturable protein binding and saturable metabolism, we sought to investigate the usefulness of therapeutic drug monitoring of unbound VPA concentration in a real-world clinical context, with a focus on clinically significant neurologic adverse outcomes." | 3.85 | Clinical Importance of Monitoring Unbound Valproic Acid Concentration in Patients with Hypoalbuminemia. ( Doré, M; Frenette, AJ; San Juan, AE; Williamson, D, 2017) |
| "Levetiracetam, a widely used antiepileptic drug in children, has been associated with psychosocial and behavioral problems, which are also influenced by epilepsy variables, including duration or seizure frequency." | 3.85 | The influence of levetiracetam on psychosocial and behavioral functioning in children: A case-control and follow-up study. ( Aydınlı, N; Bektaş, G; Çalışkan, M; Özkan, MU; Özmen, M; Tekin, U; Yıldız, EP, 2017) |
| "A limited number of anti-epileptic drugs accounted for the treatment of a majority of new patients with epilepsy (carbamazepine, lamotrigine and valproate accounted for more than 70%)." | 3.85 | Patterns of antiepileptic drug prescription in Sweden: A register-based approach. ( Berggren, F; Berling, P; Bolin, K; Gauffin, H; Landtblom, AM; Morberg, S, 2017) |
| "The aim of the study is to evaluate the association between genetic polymorphisms and valproic acid (VPA) concentration to dose ratio in children with epilepsy on VPA monotherapy." | 3.85 | Genetic polymorphisms and valproic acid plasma concentration in children with epilepsy on valproic acid monotherapy. ( Fang, F; Feng, W; Gao, B; Mei, S; Wu, X; Yang, W; Yu, Y; Zhao, Z; Zhu, L, 2017) |
| "An adolescent male with difficult to control epilepsy was admitted for impaired hepatic function while on valproic acid therapy." | 3.85 | Thrombotic microangiopathy associated with Valproic acid toxicity. ( Bohan, TP; Erikson, CL; Hebert, SA; Swinford, RD, 2017) |
| " He was found to have high anion gap metabolic acidosis with significantly elevated lactate along with an elevated osmolal gap and calcium oxalate crystals in his urine." | 3.85 | Two gaps too many, three clues too few? Do elevated osmolal and anion gaps with crystalluria always mean ethylene glycol poisoning? ( Abu Sitta, E; Gaddam, M; Kanzy, A; Velagapudi, RK, 2017) |
| "Sotalol as a drug blocking β-receptors and potassium KCNH2 channels may interact with different substances that affect seizures." | 3.85 | Sotalol enhances the anticonvulsant action of valproate and diphenylhydantoin in the mouse maximal electroshock model. ( Banach, M; Borowicz-Reutt, KK; Popławska, M, 2017) |
| "There have been several reports of congenital malformations in the offspring of mothers who took valproic acid (VPA) during pregnancy as a treatment for epilepsy." | 3.85 | Fetal Valproate Syndrome. ( Bulut, C; Çaksen, H; Mutlu-Albayrak, H, 2017) |
| " Owing to the major role of neuronal nitric oxide synthase (nNOS) in brain and ineffectiveness of antiepileptic drugs (AEDs) in restoring nitrosative stress, the present study was envisaged to evaluate the adjuvant nNOS inhibitor, 7-nitroindazole (7-NI) with valproic acid for combined treatment of epilepsy and associated depression." | 3.85 | Adjuvant neuronal nitric oxide synthase inhibition for combined treatment of epilepsy and comorbid depression. ( Goel, RK; Singh, T, 2017) |
| "This retrospective longitudinal study included 85 VPA-treated and 93 carbamazepine (CBZ)-treated (as a reference) young patients with epilepsy." | 3.83 | Cytochrome P450 2C19 polymorphisms and valproic acid-induced weight gain. ( Ishitsu, T; Kajiwara, A; Nakagawa, K; Noai, M; Oniki, K; Saruwatari, J; Soraoka, H; Tanamachi, Y, 2016) |
| "Valproic acid (VPA) is widely used in the treatment of children with epilepsy." | 3.83 | Effects of UGT2B7 Genetic Polymorphisms on Serum Concentrations of Valproic Acid in Chinese Children With Epilepsy Comedicated With Lamotrigine. ( Dong, Y; Guo, Y; Liang, M; Meng, H; Qiu, F; Wang, Q; Yun, W; Zhao, L, 2016) |
| "To confirm the hypothesis suggested above, a combined analysis of survival association of antiepileptic drug use at the start of chemoradiotherapy with temozolomide was performed in the pooled patient cohort (n = 1,869) of four contemporary randomized clinical trials in newly diagnosed glioblastoma: AVAGlio (Avastin in Glioblastoma; NCT00943826), CENTRIC (Cilengitide, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma and Methylated Gene Promoter Status; NCT00689221), CORE (Cilengitide, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma and Unmethylated Gene Promoter Status; NCT00813943), and Radiation Therapy Oncology Group 0825 (NCT00884741)." | 3.83 | Does Valproic Acid or Levetiracetam Improve Survival in Glioblastoma? A Pooled Analysis of Prospective Clinical Trials in Newly Diagnosed Glioblastoma. ( Chinot, O; Cloughesy, T; Gilbert, MR; Gorlia, T; Happold, C; Hegi, M; Mehta, MP; Nabors, LB; Perry, JR; Pugh, SL; Reardon, DA; Roth, P; Stupp, R; Weller, M; Wick, W, 2016) |
| "To identify the factors influencing topiramate pharmacokinetics (PK) in a large population of adult patients with epilepsy using population PK analysis." | 3.83 | Factors influencing topiramate clearance in adult patients with epilepsy: A population pharmacokinetic analysis. ( Bae, EK; Jang, IJ; Kim, TJ; Lee, J; Lee, KJ; Lee, SK; Moon, J; Shin, D; Shin, JW; Shin, YW, 2016) |
| "Carbamazepine is one of the three most frequently prescribed antiepileptic drugs in pregnancy." | 3.83 | Concentrations of carbamazepine and carbamazepine-10,11-epoxide in maternal and umbilical cord blood at birth: Influence of co-administration of valproic acid or enzyme-inducing antiepileptic drugs. ( Brozmanova, H; Grundmann, M; Kacirova, I, 2016) |
| "Studies of the effect of oxcarbazepine (OXC) on body growth of children with epilepsy are rare and their results are controversial." | 3.83 | Weight gain in children on oxcarbazepine monotherapy. ( Attilakos, A; Garoufi, A; Katsarou, E; Koemtzidou, E; Kossiva, L; Soldatou, A; Tsentidis, C; Vartzelis, G, 2016) |
| "Although it has been reported that some antiepileptic drugs have inducing or inhibiting effects on lamotrigine (LTG) clearance, whether they have the same effects in Asian epilepsy patients as in those in other countries has not been clarified, especially in children." | 3.83 | The effects of co-medications on lamotrigine clearance in Japanese children with epilepsy. ( Abe, S; Azuma, Y; Ishihara, N; Ito, Y; Itomi, K; Kidokoro, H; Kojima, S; Kurahashi, H; Kurahashi, N; Maruyama, K; Natsume, J; Negoro, T; Okumura, A; Suzuki, M; Takeuchi, T; Tsuji, T; Watanabe, K; Yamada, K; Yamamoto, H, 2016) |
| "The aim of this study was to compare the risk of metabolic syndrome (MS) and evaluate related factors for MS among people with epilepsy treated with valproate (VPA) or carbamazepine (CBZ)." | 3.83 | Metabolic syndrome and anticonvulsants: A comparative study of valproic acid and carbamazepine. ( Haldre, S; Kõks, S; Rakitin, A, 2016) |
| "To identify potential risk factors for the development of subclinical hypothyroidism following long-term valproic acid monotherapy in children with epilepsy." | 3.83 | Duration of valproic acid monotherapy correlates with subclinical thyroid dysfunction in children with epilepsy. ( Bogićević, D; Ilić, V; Ješić, M; Kovačević, M; Kovačević, SV; Miljković, B; Prostran, M, 2016) |
| "The alterations observed in body composition with valproic acid in contrast to other AEDs like levetiracetam, carbamazepine and phenytoin could affect treatment response in epilepsy especially in subjects with already altered body composition status like obese and thin frail patients, which needs to be established by prospective studies (CTRI/2013/05/003701)." | 3.83 | Comparison of body composition in persons with epilepsy on conventional & new antiepileptic drugs. ( Gupta, YK; Kakkar, AK; Sarangi, SC; Tripathi, M, 2016) |
| "Based on data from the EURAP observational International registry of antiepileptic drugs (AEDs) and pregnancy, we assessed changes in seizure control and subsequent AED changes in women who underwent attempts to withdraw valproic acid (VPA) during the first trimester of pregnancy." | 3.83 | Withdrawal of valproic acid treatment during pregnancy and seizure outcome: Observations from EURAP. ( Battino, D; Bonizzoni, E; Craig, J; Lindhout, D; Perucca, E; Sabers, A; Thomas, SV; Tomson, T; Vajda, F, 2016) |
| " Here, we suggest that triggering limbic seizures with low doses of PTZ in pilocarpine-treated marmosets might provide a more effective basis for the development of AED." | 3.83 | Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. ( Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM, 2016) |
| "The present study aimed to develop a neurochemistry-based single or adjuvant therapy approach for comprehensive management of epilepsy and associated depression employing pentylenetetrazole-kindled animals." | 3.83 | Evidence in support of using a neurochemistry approach to identify therapy for both epilepsy and associated depression. ( Goel, RK; Singh, T, 2016) |
| "The patients in Group I presented with adolescent-onset and related to photosensitive idiopathic generalized epilepsy (IGE), were responsive to valproic acid (VPA) or magnesium valproate (VPA-Mg) therapy, and presented a major seizure-precipitating factor in response to electronic games." | 3.83 | Clinical features of patients with game-induced seizures in the Chinese population. ( Chen, Y; Fu, Y; Huang, S; Liu, C; Long, H; Long, L; Xiao, B; Yang, X; Zhan, Q; Zhou, L; Zhou, P, 2016) |
| " Children exposed to monotherapy levetiracetam (n = 42), topiramate (n = 27), or valproate (n = 47) and a group of children born to women who had untreated epilepsy (n = 55) were enrolled retrospectively from the UK Epilepsy and Pregnancy Register." | 3.83 | Cognition in school-age children exposed to levetiracetam, topiramate, or sodium valproate. ( Baker, GA; Bromley, RL; Calderbank, R; Cheyne, CP; Clayton-Smith, J; García-Fiñana, M; Irwin, B; Morrow, JI; Rooney, C; Shallcross, R; Trayner, P, 2016) |
| "We compared persistence of antiepileptic drugs (AEDs) including carbamazepine, oxcarbazepine, gabapentin, lamotrigine, topiramate, valproic acid, and phenytoin in an Asian population with epilepsy." | 3.83 | Comparative persistence of antiepileptic drugs in patients with epilepsy: A STROBE-compliant retrospective cohort study. ( Hsieh, CY; Huang, CW; Lai, EC; Lin, SJ; Setoguchi, S; Su, CC; Yang, YK, 2016) |
| "Valproic acid (VPA) is a widely used antiepileptic drug with acceptable safety and efficacy in treating pediatric patients with various kinds of seizures." | 3.83 | Effects of UGT1A6 and GABRA1 on Standardized Valproic Acid Plasma Concentrations and Treatment Effect in Children With Epilepsy in China. ( Fang, F; Feng, W; Gao, B; Mei, S; Wu, X; Yang, W; Yu, Y; Zhao, Z; Zhu, L, 2016) |
| " This compound was effective in delaying onset of PTZ-evoked seizures at the dose of 5mg/kg in kindled animals and significantly reduced oxidative stress better than standard drug phenobarbital (PB)." | 3.81 | Design, synthesis and pharmacological evaluation of N-[4-(4-(alkyl/aryl/heteroaryl)-piperazin-1-yl)-phenyl]-carbamic acid ethyl ester derivatives as novel anticonvulsant agents. ( Kumari, S; Mishra, CB; Tiwari, M, 2015) |
| "Lamotrigine (LTG) is a widely used antiepileptic-drug (AED) for the treatment of epilepsy." | 3.81 | Effect of comedication on lamotrigine clearance in Korean epilepsy patients. ( Hong, SB; Joo, EY; Kim, HJ; Kim, TE; Lee, SY; Seo, DW, 2015) |
| "Pentylenetetrazol (PTZ)-induced chronic kindling model and lithium-pilocarpine-induced status epilepticus (SE) model were used in this study." | 3.81 | Degeneration and regeneration of GABAergic interneurons in the dentate gyrus of adult mice in experimental models of epilepsy. ( Jiang, W; Wang, Y; Wei, D; Wu, C; Wu, SX; Yang, F, 2015) |
| "Stiripentol is an antiepileptic drug (AED) approved by the European Medicines Agency for the treatment of Dravet Syndrome (DS) as adjunct treatment with valproate and clobazam." | 3.81 | Extending the use of stiripentol to other epileptic syndromes: a case of PCDH19-related epilepsy. ( Specchio, N; Trivisano, M; Vigevano, F, 2015) |
| "Carnitine deficiency is relatively common in epilepsy; risk factors reportedly include combination antiepileptic drug (AED) therapy with valproic acid (VPA), young age, intellectual disability, diet and enteral or parenteral feeding." | 3.81 | Carnitine deficiency: Risk factors and incidence in children with epilepsy. ( Fukuda, M; Ishii, E; Iwano, S; Kawabe, M; Kikuchi, C; Kuwabara, K; Morimoto, T; Suzuki, Y; Takehara, M; Wakamoto, H, 2015) |
| "This case suggests that rufinamide may induce the potentially serious adverse effect of agranulocytosis." | 3.81 | A granulocytosis associated with rufinamide: A case report. ( Awaya, T; Heike, T; Ide, M; Kato, T; Nakata, M; Saito, K; Yoshida, T, 2015) |
| "Weight gain is the most frequent adverse effect of valproic acid (VPA) treatment, resulting in poor compliance and many endocrine disturbances." | 3.81 | Association of LEPR and ANKK1 Gene Polymorphisms with Weight Gain in Epilepsy Patients Receiving Valproic Acid. ( Chen, X; Chen, Z; Hou, X; Huang, M; Li, H; Li, J; Ni, G; Su, Q; Wang, X; Xie, W; Xin, S; Zhou, L; Zhou, Y, 2015) |
| "To prospectively evaluate the long-term impact of valproate (VPA) versus carbamazepine (CBZ) on anthropometric, hormonal, and metabolic parameters in young male patients treated for epilepsy." | 3.81 | Endocrine Effects of Valproate versus Carbamazepine in Males with Epilepsy: A Prospective Study. ( de Vries, L; Goldberg-Stern, H; Itzhaki, T; Landau, Z, 2015) |
| " VPA and CBZ proved to be equally effective in Rett patients who presented seizures within the typical age range (4-5 years), while Lamotrigine (LTG) was effective for patients in whom epilepsy started later." | 3.81 | Antiepileptic drugs in Rett Syndrome. ( Baglietto, MG; Calevo, MG; Canevini, M; Giacomini, T; Giordano, L; Hayek, Y; Pintaudi, M; Renieri, A; Russo, S; Traverso, M; Veneselli, E; Vignoli, A, 2015) |
| "Valproic acid is often used in psychiatry to treat schizophrenia and other conditions outside of indication ("off-label")." | 3.81 | [Use of valproic acid in long stay units of psychiatry]. ( Chillerón-Cuenca, R; Esplá-González, S; Hernández-Pérez, P; Herraiz-Robles, P; Martínez-Lazcano, MT; Pol-Yanguas, E, 2015) |
| "In this cross-sectional study, 60 patients with epilepsy who were receiving valproate (VPA) (n = 30) or lamotrigine (LTG) (n = 30) monotherapy were enrolled." | 3.81 | Effects of antiepileptic drug monotherapy on one-carbon metabolism and DNA methylation in patients with epilepsy. ( Chen, Y; Chen, Z; Fang, Z; Huang, M; Li, H; Ni, G; Qin, J; Zhou, J; Zhou, L; Zhou, Y, 2015) |
| "Lamotrigine (LTG) is widely used in the treatment of children with epilepsy." | 3.81 | Effects of UGT1A4 genetic polymorphisms on serum lamotrigine concentrations in Chinese children with epilepsy. ( Dong, Y; Guo, Y; Liang, M; Qiu, F; Wang, Q; Yun, W; Zhao, L, 2015) |
| "The study was conducted on children aged 8-16 years who were undergoing valproic acid monotherapy for epilepsy." | 3.81 | An Evaluation of Peripapillary Retinal Nerve Fiber Layer Thickness in Children With Epilepsy Receiving Treatment of Valproic Acid. ( Akçam, M; Dereci, S; Koca, T; Türkyilmaz, K, 2015) |
| " We evaluated influence of DHA on anticonvulsant activity of AEDs phenytoin, valproate, and lamotrigine in maximal electroshock (MES), pentylenetetrazole (PTZ), and kindling models of epilepsy." | 3.81 | Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models. ( Babapour, V; Gavzan, H; Sardari, S; Sayyah, M, 2015) |
| "The aim of this study was to investigate the distribution and frequency of genetic polymorphisms in uridine diphosphate glucuronosyltransferase-2B7 (UGT2B7) in epilepsy patients and to evaluate the effect of these on the metabolism of valproic acid (VPA)." | 3.81 | The influence of UGT2B7 genotype on valproic acid pharmacokinetics in Chinese epilepsy patients. ( Huang, HW; Lin, H; Luo, YH; Peng, ZK; Sun, YX; Tang, FQ; Wang, HM; Zhuo, WY, 2015) |
| "Valproic acid (VPA) is a useful antiepileptic drug for controlling different types of epilepsy." | 3.81 | [The prevalence of obesity and metabolic syndrome in paediatric patients with epilepsy treated in monotherapy with valproic acid]. ( Carmona-Vazquez, CR; Diaz-Garcia, L; Greenawalt, SR; Pena-Landin, DM; Ruiz-Garcia, M, 2015) |
| "The purpose of the present study was to examine the relationship between the incidence of hyperammonemia and changes in the prescribing of concomitant antiepileptic drugs (AEDs) in patients receiving valproic acid." | 3.81 | Changing incidence of hyperammonemia in Japan from 2006 to 2013: expansion of new antiepileptic drugs reduces the risk of hyperammonemia. ( Imai, K; Inoue, Y; Kagawa, Y; Mishima, N; Takahashi, Y; Yamamoto, Y, 2015) |
| "To examine the effects of cytochrome P450 3A4 (CYP3A4), cytochrome P450 3A5 (CYP3A5) and ATP-binding cassette sub-family B member 1 (ABCB1) genetic polymorphisms on carbamazepine (CBZ) plasma concentrations in Chinese patients with epilepsy using CBZ as monotherapy and bitherapy with phenytoin (PHT), phenobarbital (PB), or valproic acid (VPA)." | 3.81 | Effects of CYP3A4/5 and ABCB1 genetic polymorphisms on carbamazepine metabolism and transport in Chinese patients with epilepsy treated with carbamazepine in monotherapy and bitherapy. ( Liu, DQ; Ma, HY; Sheng, YH; Wang, C; Wang, P; Yin, T; Zhou, BT, 2015) |
| "Valproic acid (VPA), which is widely used to treat epilepsy, migraine, and bipolar disorder, can causes severe hyperammonemia." | 3.81 | Influence of glutamine synthetase gene polymorphisms on the development of hyperammonemia during valproic acid-based therapy. ( Hirai, K; Imai, K; Inoue, K; Inoue, Y; Itoh, K; Suzuki, E; Takahashi, T; Takahashi, Y; Tsuji, D; Yamamoto, Y, 2015) |
| "Valproic acid (VPA) is widely used to treat various types of epilepsy." | 3.80 | Influence of uridine diphosphate glucuronosyltransferase 2B7 -161C>T polymorphism on the concentration of valproic acid in pediatric epilepsy patients. ( Hayashi, H; Imai, K; Inoue, K; Inoue, Y; Itoh, K; Koyama, S; Suzuki, E; Takahashi, T; Takahashi, Y; Tsuji, D; Yamamoto, Y; Yazawa, R, 2014) |
| "A 12-year-old patient with refractory epilepsy syndrome presented with phenytoin toxicity, following a concomitant treatment with phenytoin, valproic acid, and lamotrigine." | 3.80 | Drug interaction between phenytoin and valproic acid in a child with refractory epilepsy: a case report. ( Carnevale, RC; Carvalho, IV; de Fátima Lopes Ambrósio, R; de Queiroz, RA; dos Reis, MC; Mazzola, PG; Moriel, P; Visacri, MB, 2014) |
| "To compare the cognitive and language development of children born to women with epilepsy (WWE) exposed in utero to levetiracetam (LEV) or sodium valproate (VPA) and control children born to women without epilepsy not taking medication during pregnancy." | 3.80 | In utero exposure to levetiracetam vs valproate: development and language at 3 years of age. ( Baker, GA; Bromley, RL; Cheyne, CP; García-Fiñana, M; Irwin, B; Morrow, J; Shallcross, R, 2014) |
| " Therefore, this multicenter cross-sectional study aimed to evaluate the prevalence of reproductive endocrine dysfunctions in pubertal females with epilepsy receiving VPA, lamotrigine (LTG), or levetiracetam (LEV) monotherapy." | 3.80 | Reproductive endocrine health in pubertal females with epilepsy on antiepileptic drugs: time to screen? ( Agostinelli, S; Baumann, M; Haberlandt, E; Luef, G; Pizzolorusso, A; Prieschl, M; Rauchenzauner, M; Roscia, S; Rostasy, K; Verrotti, A; Wildt, L, 2014) |
| " Here we provide updated results from the UK Epilepsy and Pregnancy Register of the risk of MCMs after monotherapy exposure to valproate, carbamazepine and lamotrigine." | 3.80 | Malformation risks of antiepileptic drug monotherapies in pregnancy: updated results from the UK and Ireland Epilepsy and Pregnancy Registers. ( Campbell, E; Craig, J; Delanty, N; Hunt, SJ; Irwin, B; Kennedy, F; Liggan, B; Morrison, PJ; Morrow, J; Parsons, L; Russell, A; Smithson, WH, 2014) |
| "Lacosamide (LCM), a new antiepileptic drug (AED) approved as adjunctive therapy for the treatment of patients with partial-onset seizures, has limited pharmacokinetic and drug interaction data." | 3.80 | Lacosamide serum concentrations in adult patients with epilepsy: the influence of gender, age, dose, and concomitant antiepileptic drugs. ( Duncan, JS; Markoula, S; Patsalos, PN; Ratnaraj, N; Sander, JW; Teotonio, R, 2014) |
| "The aims of this study were to characterize a lamotrigine-resistant kindled model of epilepsy in mice, to study the anticonvulsant effect of carbamazepine (CBZ) and valproic acid (VPA), and to probe into the mechanism for resistance." | 3.80 | Characterization of a lamotrigine-resistant kindled model of epilepsy in mice: evaluation of drug resistance mechanisms. ( Mehndiratta, M; Pillai, KK; Singh, E, 2014) |
| "Valproic acid, a branched short-chain fatty acid, has numerous action mechanisms which turn it into a broad spectrum anticonvulsant drug and make its use possible in some other pathologies such as bipolar disorder." | 3.80 | Hyperammonemia associated with valproic acid concentrations. ( Alvariza, S; Fagiolino, P; Guevara, N; Ibarra, M; Magallanes, L; Maldonado, C; Olano, I; Olmos, I; Vázquez, M, 2014) |
| "Valproic acid, which is widely used to treat various types of epilepsy, may cause severe hyperammonemia." | 3.80 | 4217C>A polymorphism in carbamoyl-phosphate synthase 1 gene may not associate with hyperammonemia development during valproic acid-based therapy. ( Hayashi, H; Imai, K; Inoue, K; Inoue, Y; Itoh, K; Miyakawa, K; Suzuki, E; Takahashi, T; Takahashi, Y; Tsuji, D; Yamamoto, Y; Yazawa, R, 2014) |
| "To investigate biochemical cardiovascular risk factors and vascular endothelial function and structure in children with epilepsy on antiepileptic drugs (AEDs), particularly sodium valproate (VPA) and carbamazepine (CBZ)." | 3.80 | Vascular function and risk factors in children with epilepsy: associations with sodium valproate and carbamazepine. ( Keenan, N; Sadlier, LG; Wiltshire, E, 2014) |
| "Evidence from this and other studies suggests that lamotrigine and levetiracetam have low risk for teratogenesis, but that topiramate exposure early in pregnancy may be associated with dose-related anatomical teratogenesis, as valproate is already known to be." | 3.80 | The teratogenicity of the newer antiepileptic drugs - an update. ( Eadie, MJ; Graham, J; Lander, CM; O'Brien, TJ; Vajda, FJ, 2014) |
| "Hyperammonemia has been reported to be associated with patients who receive valproic acid (VPA) therapy." | 3.80 | Risk factors of hyperammonemia in patients with epilepsy under valproic acid therapy. ( Chang, CC; Chang, WN; Chen, NC; Chuang, YC; Huang, CR; Lin, CH; Lu, CH; Lu, YT; Tseng, YL, 2014) |
| "To facilitate therapeutic monitoring of antiepileptic drugs (AEDs) by healthcare professionals for patients with epilepsy (PWE), we applied a GC-MS assay to measure three AEDs: carbamazepine (CBZ), phenytoin (PHT) and valproic acid (VPA) levels concurrently in one dried blood spot (DBS), and validated the DBS-measured levels to their plasma levels." | 3.80 | Clinical validation and implications of dried blood spot sampling of carbamazepine, valproic acid and phenytoin in patients with epilepsy. ( Ho, PC; Kong, ST; Kumar, PK; Lee, WB; Lim, SH; Ng, YL; Wang, HY; Wong, PS, 2014) |
| "A 54-year-old woman with known epilepsy developed convulsions after using rifampicin and flucloxacillin, despite the use of maintenance treatment in the form of carbamazepine, valproic acid and clonazepam." | 3.80 | [Convulsions due to an interaction between anti-epileptic drugs and rifampicin]. ( Hanrath, MA; Swart, EL, 2014) |
| "The combination of lamotrigine and valproate/divalproex sodium has been shown to be effective in the treatment of refractory epilepsy." | 3.79 | Valproate and lamotrigine in pediatric patients with refractory epilepsy: after the first year. ( Thome-Souza, S; Valente, KD, 2013) |
| "Our findings suggest that the UGT1A6 (552A>C) genetic polymorphism plays a significant role in the steady state concentration of valproic acid, and it thereby has an impact on the toxicity of the valproic acid used in the patients with epilepsy." | 3.79 | The effect of uridine diphosphate glucuronosyltransferase (UGT)1A6 genetic polymorphism on valproic acid pharmacokinetics in Indian patients with epilepsy: a pharmacogenetic approach. ( Arumugam, K; Behari, M; Jain, DC; Mallayasamy, SR; Munisamy, M; Raghavan, S; Rajakannan, T; Ramanujam, B; Subbiah, V; Tripathi, M, 2013) |
| " Ten patients on valproic acid therapy of any age group with idiopathic or secondary epilepsy, who presented with encephalopathic symptoms, were registered and followed up during the study." | 3.79 | Valproic acid induced hyperammonaemic encephalopathy. ( Amanat, S; Hassan, Y; Shahbaz, N, 2013) |
| " We investigated the effects of valproic acid and topiramate on the levels of insulin, c-peptide and adipocytokines in pre-pubertal patients with idiopathic partial and generalized epilepsy." | 3.79 | The effects of topiramate and valproate therapy on insulin, c-peptide, leptin, neuropeptide Y, adiponectin, visfatin, and resistin levels in children with epilepsy. ( Aksoy, A; Aliyazicioglu, R; Deger, O; Fazlioglu, K; Karaguzel, G; Sonmez, FM; Zaman, D, 2013) |
| "The effects of the antiepileptic drugs sodium valproate (VPA) and levetiracetam (LEV) on reproductive endocrine function, sexual function, and spermatozoa were explored, together with their possible etiological mechanisms, in Chinese Han men with epilepsy." | 3.79 | Effects of antiepileptic drugs on reproductive endocrine function, sexual function and sperm parameters in Chinese Han men with epilepsy. ( Daoliang, X; Hengzhong, Z; Xiaotian, X; Yao, X; Yumei, W; Zhipan, Z, 2013) |
| " We describe the effects of focally applied valproate (VPA) in a newly emerging rat model of neocortical epilepsy induced by tetanus toxin (TeT) plus cobalt chloride (CoCl₂)." | 3.79 | Locally applied valproate enhances survival in rats after neocortical treatment with tetanus toxin and cobalt chloride. ( Altenmüller, DM; Feuerstein, TJ; Freiman, TM; Hebel, JM; Rassner, MP; Volz, S; Zentner, J, 2013) |
| " (MQ) in maximal electroshock (MES) and pentylenetetrazole (PTZ) induced rat models of epilepsy." | 3.79 | Evaluation of anti-epileptic property of Marsilea quadrifolia Linn. in maximal electroshock and pentylenetetrazole-induced rat models of epilepsy. ( Avinash, H; Chandrashekar, BR; Mukunda, N; Naduvil Narayanan, S; Nayak, BS; Raghavendra Rao, K; Sadhana, N; Satish Kumar, MC; Snehunsu, A; Vijay Kapgal, K, 2013) |
| "We studied 107 patients with epilepsy who received monotherapy with valproic acid drugs (58) and carbamazepine (49)." | 3.79 | [Season fluctuations of carbamazepine and valproate concentration in patients with epilepsy]. ( Avakian, GG; Avakian, GN; Bogomazova, MA; Delger, AB; Khromykh, EA; Lagutin, IuV; Oleĭnikova, OM, 2013) |
| "The participants included 53 epilepsy patients who received either valproic acid (VPA, n=26) or oxcarbazepine (OXC, n=27)." | 3.79 | Assessment of atherosclerosis risk due to the homocysteine-asymmetric dimethylarginine-nitric oxide cascade in children taking antiepileptic drugs. ( Arga, M; Arhan, E; Biberoglu, G; Cansu, A; Emeksiz, HC; Gulbahar, O; Hasanoglu, A; Serdaroglu, A, 2013) |
| "Valproic acid (VPA) is the most widely prescribed epilepsy treatment worldwide, but its mechanism of action remains unclear." | 3.78 | The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium. ( Bialer, M; Chang, P; Deranieh, RM; Dham, M; Greenberg, ML; Hoeller, O; Orabi, B; Shimshoni, JA; Walker, MC; Williams, RS; Yagen, B, 2012) |
| "Valproic acid (VPA) is a well-established anticonvulsant drug that has been increasingly used in the treatment of many forms of generalized epilepsy." | 3.78 | Simultaneous determination of valproic acid and 2-propyl-4-pentenoic acid for the prediction of clinical adverse effects in Chinese patients with epilepsy. ( Chen, SD; Chen, ZJ; Fang, ZY; Huang, M; Li, JL; Shu, WY; Wang, HS; Wang, XD; Zhang, Y; Zhou, JQ; Zhou, LM, 2012) |
| "The association between the superoxide dismutase 2 (SOD2) Val16Ala polymorphism and the serum aminotransferase levels was retrospectively investigated in 207 valproic acid-treated patients with epilepsy." | 3.78 | Superoxide dismutase 2 Val16Ala polymorphism is a risk factor for the valproic acid-related elevation of serum aminotransferases. ( Deguchi, M; Ishitsu, T; Kaneko, S; Nakagawa, K; Noai, M; Ogusu, N; Oniki, K; Saruwatari, J; Yasui-Furukori, N; Yoshida, S; Yoshimori, Y, 2012) |
| "The aim of this study was to investigate the genetic polymorphisms of UGT1A3, UGT1A6, and UGT2B7 in Chinese epilepsy patients and their potential influence on the pharmacokinetics of valproic acid (VPA)." | 3.78 | Influence of UDP-glucuronosyltransferase polymorphisms on valproic acid pharmacokinetics in Chinese epilepsy patients. ( Chu, XM; Hao, HP; Wang, GJ; Zhang, LF; Zhang, SN; Zhou, JH, 2012) |
| "We recruited 98 patients with epilepsy (45 taking phenytoin, 27 taking valproate, and 26 not taking any AED)." | 3.78 | Characterization of glucose homeostasis and lipid profile in adult, seizure-free, epileptic patients in Asian population. ( Geater, A; Limapichat, K; Phabphal, K; Sathirapanya, P; Setthawatcharawanich, S, 2012) |
| "Based on epidemiological data it is advised to whenever possible avoid valproic acid during pregnancy." | 3.78 | Economic evaluation of anti-epileptic drug therapies with specific focus on teratogenic outcomes. ( Boersma, C; de Jong-van den Berg, LT; Jentink, J; Postma, MJ, 2012) |
| "Hyperammonemia is one of the side effects of treatment with valproic acid (VPA), but the risk factors and mechanisms involved remain obscure." | 3.78 | Risk factors for hyperammonemia associated with valproic acid therapy in adult epilepsy patients. ( Inoue, K; Inoue, Y; Itoh, K; Kagawa, Y; Mishima, N; Suzuki, E; Takahashi, Y; Yamamoto, Y, 2012) |
| "The aim of this study was to evaluate the incidence of thyroid dysfunction during valproic acid (VPA) therapy in children and adolescents with epilepsy." | 3.78 | Subclinical hypothyroidism during valproic acid therapy in children and adolescents with epilepsy. ( Chae, JH; Chung, HR; Hwang, H; Hwang, YS; Kim, H; Kim, KJ; Kim, SH; Lim, BC, 2012) |
| " The aim of the present study was to evaluate plasma insulin, leptin, neuropeptide Y (NPY), ghrelin, and adiponectin levels in children with epilepsy treated with VPA and to evaluate these parameters for early atherosclerosis." | 3.78 | Plasma leptin, neuropeptide Y, ghrelin, and adiponectin levels and carotid artery intima media thickness in epileptic children treated with valproate. ( Aydin, K; Kiyici, A; Oran, B; Tokgoz, H, 2012) |
| "We report 2 children with a history of epilepsy in whom valproic acid (VPA) withdrawal was identified as a potential cause of hallucinations." | 3.78 | Hallucinations after withdrawal of valproic acid. ( Braun, KP; de Graeff-Meeder, ER; de Laat, SA; Hillegers, MH; Jansen, FE, 2012) |
| " We conducted a pilot study to assess the feasibility, efficacy and side-effects of VPA in the treatment of convulsive epilepsy in primary care settings in rural China as an alternative to phenobarbital." | 3.78 | Sodium valproate for epilepsy in rural China: an efficacy and safety assessment in primary care. ( Li, S; Ru, X; Sander, JW; Wang, W; Wu, J; Zheng, J; Zhu, S, 2012) |
| "We examined the influence of age and type of concomitant antiepileptic drugs (AEDs) on the pharmacokinetics of rufinamide (RUF) as well as its efficacy and safety in 51 children with refractory epilepsy." | 3.78 | Rufinamide in children with refractory epilepsy: pharmacokinetics, efficacy, and safety. ( Dahlin, MG; Ohman, I, 2012) |
| "Valproic acid (VPA) is one of the most commonly prescribed drugs for the treatment of epilepsy." | 3.78 | Effects of UGT1A6, UGT2B7, and CYP2C9 genotypes on plasma concentrations of valproic acid in Chinese children with epilepsy. ( Guo, Y; He, X; Hu, C; Qiu, F; Zhao, L, 2012) |
| "An open pilot study to evaluate the effect of pregabalin (PGB) as add-on therapy on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy (BTRE)." | 3.78 | Effect of pregabalin add-on treatment on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy: a pilot study. ( Carapella, CM; Dinapoli, L; Fabi, A; Maschio, M; Pace, A; Pompili, A; Sperati, F; Vidiri, A, 2012) |
| "Children with refractory epilepsy who suffered from severe liver function impairment during valproic acid (VPA) treatment at routine dosage were studied." | 3.78 | [Valproic acid-induced idiosyncratic liver injury in 4 cases]. ( Bao, XH; Jiang, YW; Liu, CT; Qin, J; Wu, XP; Xiong, H; Zhang, YH; Zhao, H, 2012) |
| "Weight gain is a well-known unwanted effect of valproic acid (VPA) therapy." | 3.77 | Circulating levels of allopregnanolone, a neuroactive steroid, and leptin during treatment with valproic acid in children with epilepsy. ( Balestri, P; Barlocco, EG; Casarosa, E; Grosso, S; Luisi, S; Matera, M; Mostardini, R; Petraglia, F, 2011) |
| "Many investigators agree that appropriate rational utilization of therapeutic drug monitoring (TDM) with Bayesian feedback dosage adjustment facilitates epilepsy treatment with carbamazepine (CBZ) and/or valproate (VPA) by increasing the seizure control and safety, as well as by reducing treatment costs." | 3.77 | Predictability of individualized dosage regimens of carbamazepine and valproate mono- and combination therapy. ( Andreeva, OV; Bondareva, IB; Bondareva, KI; Jelliffe, RW, 2011) |
| "Patients treated with valproic acid (VPA) present a high incidence of non-alcoholic fatty liver disease (NAFLD) (around 61%)." | 3.77 | A preliminary investigation on the possible association between diminished copper availability and non-alcoholic fatty liver disease in epileptic patients treated with valproic acid. ( Lampon, N; Tutor, JC, 2011) |
| "Pre-morning-dose serum valproic acid concentrations were measured in 76 subjects with epilepsy (48 M, 28 F, age range 6-20 years, mean age 14 years) in whom lamotrigine was added while the dose of valproate and other medication remained unchanged." | 3.77 | The effect of lamotrigine on valproic acid concentrations. ( Berry, DJ; Besag, FM; Besag, FP; Martin, AC, 2011) |
| "Valproic acid monotherapy is associated with NAFLD in a high percentage of adolescents with epilepsy who have typical VPA-related metabolic disturbances." | 3.77 | Nonalcoholic fatty liver disease in adolescents receiving valproic acid. ( Agostinelli, S; Chiarelli, F; Coppola, G; Parisi, P; Verrotti, A, 2011) |
| "Children born to women with epilepsy (WWE), exposed in utero to levetiracetam (LEV, n = 51), were assessed for early cognitive development and compared to children exposed to sodium valproate in utero (VPA, n = 44) and a group of children representative of the general population (n = 97)." | 3.77 | Child development following in utero exposure: levetiracetam vs sodium valproate. ( Baker, GA; Bonnett, LJ; Bromley, RL; Irwin, B; Morrow, J; Shallcross, R, 2011) |
| "Extractive electrospray ionization mass spectrometry is shown to allow real-time, in vivo drug monitoring and pharmacokinetic measurement in a non-invasive, pain-free manner as demonstrated by the mass spectral measurement of a novel exhaled breath biomarker for valproic acid, a medication used to control epilepsy." | 3.77 | Real-time, in vivo monitoring and pharmacokinetics of valproic acid via a novel biomarker in exhaled breath. ( Azov, V; Chen, H; Chingin, K; Disko, A; Gamez, G; Krämer, G; Zenobi, R; Zhu, L, 2011) |
| "This study aims to investigate the alteration of iron homeostasis and oxidative stress status in epilepsy patients treated with valproic acid (VPA) monotherapy." | 3.77 | Increase in non-transferrin bound iron and the oxidative stress status in epilepsy patients treated using valproic acid monotherapy. ( Atroshi, F; Fucharoen, S; Kaipainen, P; Kaski, M; Ounjaijean, S; Partinen, M; Plonka-Poltorak, E; Srichairatanakool, S; Westermarck, T, 2011) |
| "Lamotrigine (LTG) which has a widespread use in epilepsy treatment as an antiepileptic agent is metabolized by UDP-glucuronosyl transferase (UGT) enzymes." | 3.77 | The relationship between UGT1A4 polymorphism and serum concentration of lamotrigine in patients with epilepsy. ( Aker, RG; Goren, MZ; Gulcebi, MI; Onat, FY; Ozkara, C; Ozkaynakcı, A, 2011) |
| "The aim of this study was to establish the population protein binding parameters of valproic acid (VPA) in patients with epilepsy receiving VPA monotherapy and those receiving VPA combined with other antiepileptic drugs." | 3.77 | No effect of co-administered antiepileptic drugs on in-vivo protein binding parameters of valproic acid in patients with epilepsy. ( Abe, T; Itoh, H; Nishimura, F; Sato, Y; Suzuki, Y; Takeyama, M, 2011) |
| "Increased serum levels of leptin, NPY and galanin play an important role in VPA-associated weight gain in children." | 3.77 | Serum insulin, cortisol, leptin, neuropeptide Y, galanin and ghrelin levels in epileptic children receiving valproate. ( Camurdan, O; Cansu, A; Cinaz, P; Hırfanoğlu, T; Serdaroglu, A, 2011) |
| "Our study underscores the importance of considering drugs as a cause and a contributor to pancreatitis in children, particularly valproic acid in young children." | 3.77 | Novel characterization of drug-associated pancreatitis in children. ( Bai, HX; Bhandari, V; Husain, SZ; Latif, SU; Ma, MH; Orabi, AI; Park, A, 2011) |
| "A retrospective cohort study using a large health insurance plan claims database comparing patients with epilepsy who switched from brand to generic equivalent phenytoin, lamotrigine, or divalproex after 6 months (switch cohorts) to matched patients who remained on the brand (nonswitch cohorts)." | 3.77 | Clinical and pharmacy utilization outcomes with brand to generic antiepileptic switches in patients with epilepsy. ( Curtis, B; Erickson, SC; Harada, AS; Le, L; Ramsey, SD; Solow, BK; Stockl, KM; Zakharyan, A, 2011) |
| "Valproic acid, which current guidelines suggest should be avoided in pregnancy, was most notable in terms of strength and breadth of its associations." | 3.77 | Use of antiepileptic medications in pregnancy in relation to risks of birth defects. ( Ahrens, KA; Anderka, MT; Bosco, JL; Gilboa, SM; Holmes, LB; Mitchell, AA; Werler, MM, 2011) |
| "Our study was carried out to ascertain the role of valproic acid for inducing metabolic disorders like hyperinsulinemia, insulin resistance and metabolic syndrome." | 3.77 | Fasting insulin and HOMA-index changes in patients treated with valproic acid. ( Javashvili, L; Kasradze, S; Mania, M; Okujava, N, 2011) |
| "We investigated the effect of lamotrigine (LTG) add-on therapy in 50 patients with childhood-onset refractory epilepsy (25 males and 25 females): 15 with localization-related epilepsy, 33 with generalized epilepsy, and 2 with undetermined epilepsy." | 3.77 | [Lamotrigine add-on therapy for childhood-onset refractory epilepsy: comparison of the efficacy between 3 months and 6 months after initiation]. ( Endoh, F; Kobayashi, K; Ohtsuka, Y; Watanabe, K; Yoshinaga, H, 2011) |
| "This prospective study was designed to investigate whether or not monotherapy with sodium valproate (VPA) or oxcarbazepine (OXC) affects plasma levels of fatty acylcarnitine esters in children with epilepsy." | 3.77 | Analysis of acylcarnitine levels by tandem mass spectrometry in epileptic children receiving valproate and oxcarbazepine. ( Biberoglu, G; Cansu, A; Ezgu, FS; Hasanoglu, A; Hirfanoglu, TL; Serdaroglu, A; Tumer, L, 2011) |
| " We previously showed that tolerance to levetiracetam (LEV) developed within 4 days after the start of the treatment in a rat model for spontaneous seizures after electrically induced status epilepticus." | 3.76 | Improved seizure control by alternating therapy of levetiracetam and valproate in epileptic rats. ( Edelbroek, PM; Gorter, JA; van Vliet, EA, 2010) |
| "Valproic acid (VPA) is widely used clinically in epilepsy, bipolar disorder, and migraine." | 3.76 | Inhibition of long-term potentiation by valproic acid through modulation of cyclic AMP. ( Chandler, KE; Chang, P; Walker, MC; Williams, RS, 2010) |
| "Young adult outpatients with epilepsy on monotherapy for no less than 6 months with carbamazepine (CBZ), valproic acid (VPA), oxcarbazepine (OXC) and topiramate (TPM) were examined." | 3.76 | Effects of the antiepileptic drugs on peripheral nerve function. ( Boylu, E; Domaç, FM; Misirli, H; Saraçoğlu, M; Senol, MG, 2010) |
| "Levetiracetam (LEV, 2S-(oxo-1-pyrrolidinyl)butanamide, Keppra, UCB Pharma) is a new anti-epileptic drug used to treat certain types of seizures in epilepsy patients." | 3.76 | Levetiracetam inhibits interleukin-1 beta inflammatory responses in the hippocampus and piriform cortex of epileptic rats. ( Choi, HC; Choi, SY; Jo, SM; Kang, TC; Kim, DS; Kim, JE; Kim, YI; Song, HK, 2010) |
| "Valproic acid (VPA) has been used for epilepsy treatment since the 1970s." | 3.76 | Valproic acid in the complex therapy of malignant tumors. ( Eckschlager, T; Hrabeta, J; Hrebackova, J, 2010) |
| "The study comprised 40 children and adolescents with idiopathic epilepsy on either valproate or carbamazepine." | 3.76 | Growth hormone levels in children and adolescents with epilepsy. ( Al-Badani, AK; Aly, GS; El-Khayat, HA; Mamdouh, RM; Mohamed, EI; Tomoum, HY, 2010) |
| "Two severely disabled children with epilepsy, a 6-year-old boy and a 15-year-old girl, had been treated with valproic acid from the ages of 5 and 6 months, respectively, and developed Fanconi syndrome." | 3.76 | Fanconi syndrome caused by valproic acid. ( Endo, A; Fuchigami, T; Fujita, Y; Mugishima, H; Takahashi, S, 2010) |
| "In order to clarify the factors causing hyperammonemia and to predict occurrences during treatment with valproic acid (VPA), we investigated the effect of the genetic polymorphism of carbamoyl-phosphate synthase 1 (CPS14217C>A) on susceptibility of hyperammonemia, together with the effect of coadministration of other anticonvulsants." | 3.76 | Effect of CPS14217C>A genotype on valproic-acid-induced hyperammonemia. ( Kawasaki, Y; Matsuo, M; Nakamura, T; Okamura, N; Okizuka, Y; Okumura, K; Oyazato, Y; Sakaeda, T; Tsuneishi, S; Yagi, M, 2010) |
| " Patients with clinically stable partial or generalized epilepsy, already receiving lamotrigine or valproic acid on monotherapy, were assessed in two visits: baseline and at 6 months." | 3.76 | Quality of life and treatment satisfaction in Spanish epilepsy patients on monotherapy with lamotrigine or valproic acid. ( Barriga, J; Cobaleda, S; Codina, M; Lahuerta, J; Morales, MD; Viteri, C, 2010) |
| "Lamotrigine (LTG) is increasingly being prescribed in pregnancy for women with epilepsy in place of valproate (VPA), because of the teratogenic risks associated with the latter." | 3.76 | Is lamotrigine a significant human teratogen? Observations from the Australian Pregnancy Register. ( Eadie, MJ; Graham, JE; Hitchcock, AA; Lander, CM; O'Brien, TJ; Vajda, FJ, 2010) |
| " The influence of age and concomitant medications on the dose/concentration ratio of levetiracetam was examined in 103 children with epilepsy." | 3.76 | Age and comedications influence levetiracetam pharmacokinetics in children. ( Dahlin, MG; Ohman, I; Wide, K, 2010) |
| " Between 1999 and 2004, we enrolled pregnant women with epilepsy who were taking a single AED (carbamazepine, lamotrigine, phenytoin, or valproate)." | 3.76 | Effects of breastfeeding in children of women taking antiepileptic drugs. ( Baker, GA; Browning, N; Clayton-Smith, J; Cohen, M; Combs-Cantrell, DT; Kalayjian, LA; Kanner, A; Liporace, JD; Loring, DW; Meador, KJ; Pennell, PB; Privitera, M, 2010) |
| " In utero, exposure to valproic acid (VPA) and phenytoin (PH) may cause congenital malformations and also withdrawal symptoms such as irritability, jitteriness and symptoms of hypoglycemia." | 3.76 | Neonatal episodic hypoglycemia: a finding of valproic acid withdrawal. ( Akçakuş, M; Akın, MA; Çoban, D; Güneş, T; Kurtoğlu, S, 2010) |
| "We evaluated the serum leptin and insulin as predictors of weight gain in children receiving long-term treatment with valproate (VPA), carbamazepine (CBZ), lamotrigine (LTG)." | 3.75 | States of serum leptin and insulin in children with epilepsy: risk predictors of weight gain. ( Fida, NM; Hamed, EA; Hamed, SA, 2009) |
| "Valproic acid-associated weight gain may occur in young children." | 3.75 | Body mass index and serum lipid changes during treatment with valproic acid in children with epilepsy. ( Balestri, P; Grosso, S; Mostardini, R; Piccini, B, 2009) |
| "There are few reports on valproic acid related to thrombophilia." | 3.75 | Thrombophilic risk factors in epileptic children treated with valproic Acid. ( Akar, N; Deda, G; Ertem, M; Teber, S; Unal, O, 2009) |
| "Valproic acid (VPA) is effective for the treatment of many types of epilepsy, but its use can be associated with an increase in body weight." | 3.75 | Nonalcoholic fatty liver disease during valproate therapy. ( Chiarelli, F; Di Marco, G; la Torre, R; Pelliccia, P; Verrotti, A, 2009) |
| "The long-term effects of valproic acid (VPA) on reproductive endocrine functions in women with epilepsy (WWE) were studied." | 3.75 | Long-term effects of valproic acid on reproductive endocrine functions in Turkish women with epilepsy. ( Dogan, EA; Genc, BO; Genc, E; Gorkemli, H; Ozdemir, S, 2009) |
| "The aim of this study is to evaluate the erythrocyte lipid peroxidation and antioxidant enzyme levels in patients with newly diagnosed idiopathic epilepsy before treatment and in patients treated with valproic acid for idiopathic epilepsy." | 3.75 | Effects of epilepsy and valproic acid on oxidant status in children with idiopathic epilepsy. ( Dirik, E; Kuralay, F; Kurul, SH; Seçkin, E; Yiş, U, 2009) |
| "Between 1999 and 2004, we enrolled pregnant women with epilepsy who were taking a single antiepileptic agent (carbamazepine, lamotrigine, phenytoin, or valproate) in a prospective, observational, multicenter study in the United States and the United Kingdom." | 3.75 | Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs. ( Baker, GA; Browning, N; Clayton-Smith, J; Cohen, M; Combs-Cantrell, DT; Kalayjian, LA; Kanner, A; Liporace, JD; Loring, DW; Meador, KJ; Pennell, PB; Privitera, M, 2009) |
| " We point out that during the pregnancy 4 of these 5 women with epilepsy had taken valproates, and the other one--carbamazepine." | 3.75 | [Fetal malformations in women with epilepsy]. ( Bozhinov, P; Bozhinova, C; Markova, C, 2009) |
| "This substudy of the Neurodevelopmental Effects of Antiepileptic Drugs investigation enrolled pregnant women with epilepsy on AED monotherapy (carbamazepine, lamotrigine, and valproate)." | 3.75 | A prospective study of cognitive fluency and originality in children exposed in utero to carbamazepine, lamotrigine, or valproate monotherapy. ( Gaillard, WD; McVearry, KM; Meador, KJ; VanMeter, J, 2009) |
| "(1) Numerous follow-up studies of pregnancies in women with epilepsy show that valproic acid is more teratogenic than other antiepileptics." | 3.75 | Valproic acid: long-term effects on children exposed in utero. ( , 2009) |
| " Hyperhomocysteinemia was defined as fasting total Hcy above 12 micromol/L and/or post-methionine load concentrations above 38 micromol/L." | 3.74 | Drug-induced pertubation of the aminothiol redox-status in patients with epilepsy: improvement by B-vitamins. ( Apeland, T; Frøyland, ES; Kristensen, O; Mansoor, MA; Strandjord, RE, 2008) |
| "Although valproic acid (VPA) is used extensively for treating various kinds of epilepsy, it causes hepatotoxicity and teratogenicity." | 3.74 | Tetramethylcyclopropyl analogue of the leading antiepileptic drug, valproic acid: evaluation of the teratogenic effects of its amide derivatives in NMRI mice. ( Bialer, M; Fujiwara, M; Kaufmann, D; Okada, A; Onishi, Y; Shimshoni, JA; Yagen, B, 2008) |
| " In 5 pediatric patients with severe myoclonic epilepsy and valproic acid-induced liver failure, we identified 1 novel and 4 previously described pathogenic mutations in the linker region of this enzyme." | 3.74 | Clonally expanded mitochondrial DNA mutations in epileptic individuals with mutated DNA polymerase gamma. ( Baron, M; Bös, M; Chinnery, PF; Elger, CE; Kornblum, C; Kunz, WS; Sassen, R; Stewart, JD; Taylor, RW; Zsurka, G, 2008) |
| " This retrospective study of children with epilepsy, aged <12 years at enrollment, examined weight gain associated with valproic acid or carbamazepine monotherapy." | 3.74 | Lack of valproic acid-associated weight gain in prepubertal children. ( Baumann, RJ; Espinosa, PS; Mendiondo, MS; Robertson, WC; Salazar, JC; Yu, L, 2008) |
| "Folic acid supplementation reduces the occurrence of neural tube defects (NTDs); however, it is not clear whether it protects against teratogenic effects of antiepileptic drugs." | 3.74 | Plasma vitamin values and antiepileptic therapy: case reports of pregnancy outcomes affected by a neural tube defect. ( Boisson, C; Candito, M; Gaucherand, P; Guéant, JL; Luton, D; Naimi, M; Rudigoz, JC; Van Obberghen, E, 2007) |
| "Five oral formulations of valproic acid (VPA)/divalproex sodium are approved and commonly used in the US for treatment of epilepsy, mania/bipolar disorder and migraine prophylaxis." | 3.74 | Distinct absorption characteristics of oral formulations of valproic acid/divalproex available in the United States. ( Dutta, S; Reed, RC, 2007) |
| "To compare the incidence and magnitude of weight gain associated with valproic acid (VPA) monotherapy in male and female epilepsy patients and to determine possible gender-specific differences in frequency of carbohydrate craving, body-composition, glucose homeostasis and lipid metabolism." | 3.74 | Valproate, weight gain and carbohydrate craving: a gender study. ( Bauer, G; El-Khatib, F; Hoppichler, F; Lechleitner, M; Luef, GJ; Naser, A; Rauchenzauner, M; Trinka, E; Unterberger, I; Waldmann, M, 2007) |
| "To determine the influence of valproate (VPA) treatment on acylcarnitines in children with epilepsy." | 3.74 | Effects of valproate on acylcarnitines in children with epilepsy using ESI-MS/MS. ( Gerstner, T; Koenig, SA; Kohlmueller, D; Longin, E; Mehlem, P; Schulze, A; Teich, M; Treiss, I; Werner, T, 2007) |
| "To search for association between the 163G>A polymorphism of the fatty acid binding protein 2 (FABP2) gene and intracellular transport of the valproic acid in the small intestines, 168 patients with different forms of epilepsy, aged from 1 to 89 years, and different illness duration have been studied." | 3.74 | [An association between the FABP2 gene polymorphism and efficacy of valproates]. ( Aksenova, MG; Avakian, GN; Badalian, OL; Belousova, ED; Burd, SG; Dorofeeva, MIu; Gusev, EI; Kachalin, EIu; Savenkov, AA; Tertyshnik, OIu, 2007) |
| "Ecto-nucleotidases, one of the main mechanisms involved in the control of adenosine levels in the synaptic cleft, have shown increased activities after the pilocarpine model of epilepsy." | 3.74 | Antiepileptic drugs prevent changes induced by pilocarpine model of epilepsy in brain ecto-nucleotidases. ( Bogo, MR; Bonan, CD; Bruno, AN; Cognato, Gde P; da Silva, RS; Sarkis, JJ, 2007) |
| "Using the mouse maximal electroshock-induced seizure model, indicative of tonic-clonic seizures in humans, the present study was aimed at characterizing the interaction between remacemide and valproate, carbamazepine, phenytoin, and phenobarbital." | 3.74 | Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshock. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ; Malek, R; Patsalos, PN; Ratnaraj, N, 2007) |
| "Chronic antiepileptic therapy with valproic acid (VPA) is associated with increased body weight and insulin resistance in adults and children." | 3.74 | Adiponectin and visfatin concentrations in children treated with valproic acid. ( Ebenbichler, CF; Ernst, B; Haberlandt, E; Hoppichler, F; Karall, D; Luef, G; Rauchenzauner, M; Rostasy, K; Scholl-Bürgi, S, 2008) |
| "Valproic acid (VPA) is a commonly prescribed anticonvulsant drug for the treatment of various forms of epilepsy." | 3.74 | [Seven cases of decreased serum valproic acid concentration during concomitant use of carbapenem antibiotics]. ( Joo, JY; Kim, JH; Kwon, OH; Lee, SG, 2007) |
| " A total of 25 children with idiopathic epilepsy (8 valproate, 11 carbamazepine, and 6 oxcarbazepine) and 10 healthy children were included in the study." | 3.74 | Homocysteine levels in epileptic children receiving antiepileptic drugs. ( Kurul, S; Unalp, A; Yiş, U, 2007) |
| " We previously reported biochemical evidence of increased bone turnover in premenopausal women with epilepsy on phenytoin monotherapy compared with those on carbamazepine, lamotrigine, and valproate." | 3.74 | Bone health in young women with epilepsy after one year of antiepileptic drug monotherapy. ( McMahon, DJ; Morrell, MJ; Pack, AM; Randall, A; Shane, E, 2008) |
| "Therapeutic efficacy of valparin xr, a new form of valproic acid (VPA) generic drugs, manufactured by "Torrent Pharmaceuticals Ltd", India, has been studied in 25 patients with epilepsy of different types and frequency of seizures." | 3.74 | [The use of generic valparin xr in the treatment of epilepsy.]. ( Gromov, SA; Lipatova, LV, 2007) |
| "Hypospadias is one of the most frequently occurring genital anomalies described in infants prenatally exposed to valproic acid (VA)." | 3.74 | Risk of hypospadias in newborn infants exposed to valproic acid during the first trimester of pregnancy: a case-control study in Spain. ( Fernández, P; Martínez-Frías, ML; Mejías, C; Prieto-Merino, D; Rodríguez-Pinilla, E, 2008) |
| "The aim of our study was to investigate whether a correlation exists between steady-state serum concentration of valproic acid and quality of life in adolescent patients with epilepsy." | 3.74 | Inverse correlation of valproic acid serum concentrations and quality of life in adolescents with epilepsy. ( Jakovljevic, MB; Jankovic, SM; Jankovic, SV; Todorovic, N, 2008) |
| " The combination of AGLD (5 mg/kg) with phenobarbital (PB, applied at its subeffective dose of 15 mg/kg) significantly shortened motor seizure and afterdischarge duration in amygdala-kindled seizures." | 3.73 | Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats. ( Borowicz, KK; Czuczwar, SJ, 2005) |
| " We studied premenopausal women with epilepsy receiving antiepileptic drug monotherapy (phenytoin, carbamazepine, valproate, and lamotrigine)." | 3.73 | Bone mass and turnover in women with epilepsy on antiepileptic drug monotherapy. ( Doñe, S; Flaster, E; Holloway, L; Marcus, R; Morrell, MJ; Pack, AM; Randall, A; Seale, C; Shane, E, 2005) |
| "To report a probable interaction between meropenem and valproic acid that resulted in the development of epileptic seizures." | 3.73 | Acute seizures due to a probable interaction between valproic acid and meropenem. ( Borrás-Blasco, J; Coves-Orts, FJ; Murcia-López, A; Navarro-Ruiz, A; Palacios-Ortega, F, 2005) |
| "To determine the rate of occurrence of major malformations in infants whose mothers had taken the drug valproic acid (VPA) as monotherapy during the first trimester of pregnancy and had enrolled in the North American Antiepileptic Drug Pregnancy Registry." | 3.73 | Increased rate of major malformations in offspring exposed to valproate during pregnancy. ( Alsdorf, RM; Holmes, LB; Nambisan, M; Smith, CR; Surve, T; Wyszynski, DF, 2005) |
| " Serum interleukin-5 levels were measured with enzyme-linked immunosorbent assay technique in 68 children with epilepsy receiving sodium valproate monotherapy and compared with the levels of 60 healthy controls and 14 children with epilepsy receiving carbamazepine." | 3.73 | Valproate-induced eosinophilia in children with epilepsy: role of interleukin-5. ( Bourantas, KL; Kateri, MD; Makis, AC; Papadopoulou, ZL; Tzoufi, M, 2005) |
| " However, he was found to have hyperammonemia within 2 weeks after the addition of low-dose topiramate to valproate." | 3.73 | Topiramate-valproate-induced hyperammonemic encephalopathy syndrome: case report. ( Cheung, E; Fung, CW; Wong, V, 2005) |
| "Across a range of assumptions used, the risk of hospitalization for Stevens-Johnson syndrome or toxic epidermal necrolysis in new users is low for carbamazepine, lamotrigine, phenytoin, phenobarbital, and valproic acid." | 3.73 | Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptics. ( Messenheimer, J; Mockenhaupt, M; Schlingmann, J; Tennis, P, 2005) |
| "This study evaluated the effect of the addition of zonisamide on valproic acid (valproate sodium) pharmacokinetics under steady-state conditions in patients with epilepsy." | 3.73 | Lack of pharmacokinetic interactions between steady-state zonisamide and valproic acid in patients with epilepsy. ( Brodie, M; Grundy, JS; Levy, RH; Ragueneau-Majlessi, I; Shah, J; Smith, D, 2005) |
| "To evaluate whether the administration of lamotrigine (LTG) or valproate (VPA) changes concentrations of plasma total homocysteine (tHcy), plasma and red-cell folate and plasma Vitamin B-12, we measured these indices in a total of 20 patients with epilepsy before and after a 32-week period of monotherapy of LTG or VPA." | 3.73 | Blood homocysteine, folate and vitamin B-12 concentrations in patients with epilepsy receiving lamotrigine or sodium valproate for initial monotherapy. ( Gidal, BE; Hammer, A; Tamura, T; Vuong, A, 2005) |
| "Serum concentrations of valproate were reduced and seizures were exacerbated by concomitant meropenem therapy in a child with a neurodegenerative disorder and epilepsy." | 3.73 | Seizure worsening caused by decreased serum valproate during meropenem therapy. ( Parmeggiani, A; Riva, R; Santucci, M, 2005) |
| " Replacement of phenytoin by valproic acid resulted in a 100-lb weight gain, exacerbation of sleep apnea, and right heart failure." | 3.73 | Lethal obesity associated with sodium valproate in a brain-injured patient. ( Althoff, RR; Black, DN; Daye, K; Pelletier, CA, 2005) |
| "Valproic acid has been widely used for the treatment of epilepsy." | 3.73 | [Hyperammonemia secondary to the use of valproic acid: case report]. ( Fernandes, RM; Funayama, CA; Turcato, Mde F; Wichert-Ana, L, 2005) |
| "The aim of the study was to obtain pharmacokinetic data for carbamazepine (CBZ) and its fractions not bound with proteins in bitherapy with lamotrigine (LTG), topiramate (TPM), vigabatrin (VGB) or valproic acid (VPA) in children and adolescents treated for epilepsy." | 3.73 | Pharmacokinetic interactions of carbamazepine with some antiepileptic drugs during epilepsy treatment in children and adolescents. ( Steinborn, B, 2005) |
| "Five patients with idiopathic generalized epilepsies (IGE) treated with lamotrigine (LTG) experienced exacerbation or de novo appearance of myoclonic jerks (MJ)." | 3.73 | Lamotrigine associated with exacerbation or de novo myoclonus in idiopathic generalized epilepsies. ( Baldy-Moulinier, M; Berramdane, M; Coubes, P; Crespel, A; Gelisse, P; Genton, P; Monicard, C, 2005) |
| "Authors presented the data on the efficacy and tolerability of the new anticonvulsant drug topiramate (topamax) in the treatment of 110 children aged from 6 months to 16 years with pharmacoresistant types of epilepsy including 42 patients with tuberous sclerosis." | 3.73 | [The efficacy of topiramate (topamax) in the treatment of resistant epilepsy in children]. ( Belousova, ED; Dorofeeva, MIu; Ermakov, AIu, 2005) |
| " We identified a patient with a positive family history for episodic ataxia, who was originally diagnosed with epilepsy and treated with valproic acid." | 3.73 | CACNA1A mutation in a EA-2 patient responsive to acetazolamide and valproic acid. ( Bulman, DE; Friedman, JH; Scoggan, KA, 2006) |
| ") continuous valproic acid (VPA) infusion, as compared with acute injections in the kindling epilepsy model." | 3.73 | Effect of intracerebroventricular continuous infusion of valproic acid versus single i.p. and i.c.v. injections in the amygdala kindling epilepsy model. ( Alós, M; Barcia, JA; Durán, C; Hernández, ME; Ortiz, P; Serralta, A, 2006) |
| "To evaluate the influence of aging on the pharmacokinetics of valproic acid (VPA) at steady-state and on the susceptibility of VPA metabolism to enzyme induction by antiepileptic comedication." | 3.73 | The influence of old age and enzyme inducing comedication on the pharmacokinetics of valproic acid at steady-state: A case-matched evaluation based on therapeutic drug monitoring data. ( Battino, D; Croci, D; Fattore, C; Mamoli, D; Messina, S; Perucca, E, 2006) |
| "A 55-year-old woman was diagnosed with pneumonia and was treated with meropenem; 5 days later she developed epileptic seizures." | 3.73 | Epileptic seizures caused by low valproic acid levels from an interaction with meropenem. ( Carcas, A; Fudio, S; Ortega, R; Piñana, E, 2006) |
| "Morning urine samples were collected from children with epilepsy receiving VPA (n = 25), carbamazepine (n = 16), or clobazam (n = 12) for > or = 4 weeks and from age-matched control subjects (n = 39)." | 3.73 | Oxidative stress in children receiving valproic acid. ( Abbott, FS; Chang, TK; Farrell, K; Michoulas, A; Teng, XW; Tong, V, 2006) |
| "In order to evaluate the results of epilepsy treatment in children and adolescents the influence of two antiepileptic drugs (AED) carbamazepine (CBZ) and valproates (VPA) on cognitive functions of epileptic children and adolescents was analyzed." | 3.73 | [Long latency auditory evoked potentials in schoolchildren and adolescents with epilepsy]. ( Zgorzalewicz, M, 2006) |
| " The mother had been treated with valproic acid (1800mg per day) and lamotrigine (100mg per day) throughout pregnancy." | 3.72 | Valproic acid and lamotrigine treatment during pregnancy. The risk of chromosomal abnormality. ( Cogulu, O; Gunduz, C; Kultursay, N; Ozkinay, F; Yilmaz, D, 2003) |
| "This open-label, cross-sectional study compared (1) endocrine and lipid measures during the early follicular phase of the menstrual cycle; (2) prevalence of menstrual disorders (from patient diaries recorded over three cycles); and (3) body weight of women with epilepsy on lamotrigine monotherapy (n=119) with those on valproate monotherapy (n=103) for <5 years." | 3.72 | Higher androgens and weight gain with valproate compared with lamotrigine for epilepsy. ( Ayala, R; Dam, M; Gomez, G; Isojärvi, J; Messenheimer, J; Morrell, MJ; O'Neill, F; Taylor, AE; Tennis, P, 2003) |
| "This study aimed to assess the risks and benefits of the co-administration of lamotrigine and valproate in a pediatric population with refractory epilepsy." | 3.72 | Lamotrigine and valproate: efficacy of co-administration in a pediatric population. ( Fiore, LA; Freitas, A; Thomé-Souza, S; Valente, KD, 2003) |
| "A 5-year-old female developed alteration of consciousness during 3 days of long-term treatment with valproic acid for localization-related epilepsy." | 3.72 | Reversible altered consciousness with brain atrophy caused by valproic acid. ( Eguchi, M; Imataka, G; Nakagawa, E; Ota, T; Yamanouchi, H, 2003) |
| "A group of 105 women (54 of whom were, and had only ever been, taking valproate for at least a year, and 51 who had only ever taken either lamotrigine or carbamazepine, for at least a year) were compared with a group of 50 women who did not have epilepsy: any oral contraceptive taken at the time of testing was recorded and blood levels of follicle stimulating hormone (FSH), luteinising hormone (LH), testosterone and prolactin were estimated from days 2 to 6 of the menstrual cycle (day 1 being the first day of bleeding) and an MRI scan made of their pelvis." | 3.72 | A study of anticonvulsant medication on ovarian function in a group of women with epilepsy who have only ever taken one anticonvulsant compared with a group of women without epilepsy. ( Betts, T; Dutton, N; Greenhill, L; Rolfe, T; Yarrow, H, 2003) |
| "Two months-old girl with psychomotor retardation had aminophylline-resistant apnea attacks and was investigated by video-EEG recording." | 3.72 | [A case of infantile epileptic apnea with congenital brain anomaly]. ( Hamano, K; Iwasaki, N; Matsui, A; Ohto, T; Takahashi, M; Tanaka, R, 2003) |
| "0803 * INDI, in which CBZ indicates co-administration of carbamazepine, VPADD the daily dose of VPA and INDI uncontrolled epilepsy." | 3.72 | Pharmacokinetic modelling of valproic acid from routine clinical data in Egyptian epileptic patients. ( Cosson, V; EL Desoky, ES; EL Din Amry, S; Fuseau, E, 2004) |
| "To investigate the effect of antiepileptic drugs, especially carbamazepine and valproate, on intelligence in prenatally exposed children of mothers with epilepsy." | 3.72 | Normal intelligence in children with prenatal exposure to carbamazepine. ( Bardy, A; Gaily, E; Granström, ML; Hiilesmaa, V; Isoaho, M; Kaaja, E; Kantola-Sorsa, E; Kotila, M; Matila, R; Nylund, T, 2004) |
| "A 70-year-old woman under anticonvulsive therapy with carbamazepine and valproate was diagnosed as polymyalgia rheumatica." | 3.72 | [A case of polymyalgia rheumatica with improved steroid-responsibility after discontinuing carbamazepine]. ( Katada, S; Kobayashi, H; Sato, A; Sato, M, 2004) |
| "Dizocilpine inhibits the seizure of the amygdala kindling and improve the antiepileptic activity of phenobarbital, valproate and nicardipine, indicating that these combination may provide a new approach for treating epilepsy." | 3.72 | Effect of combination of dizocilpine with general antiepileptic drugs on amygdala kindling models in rats. ( Gao, GM; Yang, ZH; Yue, W; Zhao, YJ; Zhong, WZ, 2004) |
| "To investigate the possible role of valproic acid therapy in the development of the weight gain and hyperinsulinemia of epileptic patients." | 3.72 | [Insulin resistance in epileptic patients during treatment of valproic acid]. ( Bao, YY; Chen, Z; Ding, MP; Liu, ZR; Xu, LL, 2004) |
| " Twenty-eight patients were taking carbamazepine (CBZ); five, lamotrigine (LTG); 12, oxcarbazepine (OXC); and 25, valproate (VPA) as monotherapy for epilepsy." | 3.72 | Serum androgen levels and testicular structure during pubertal maturation in male subjects with epilepsy. ( Isojärvi, JI; Mikkonen, K; Päivänsalo, M; Pakarinen, AJ; Tapanainen, P; Vainionpää, LK, 2004) |
| " Anthropometric measurements, staging of pubertal maturation, and clinical manifestations of hyperandrogenism were assessed, as well as measurement of serum levels of testosterone, dehydroepiandrosterone sulfate (DHEAS), sex hormone-binding globulin (SHBG), and free androgen index (FAI)." | 3.72 | Physical growth and endocrinal disorders during pubertal maturation in girls with epilepsy. ( Abd El-Basset, FZ; El Barbary, NS; El-Khayat, HA; Hakky, SM; Mohamed, MS; Nassef, NM; Tohamy, SM; Tomoum, HY; Zaky, AA, 2004) |
| "The nootropic drug piracetam was investigated in various experimental models of epilepsy." | 3.72 | Effects of piracetam alone and in combination with antiepileptic drugs in rodent seizure models. ( De Sarro, G; Fischer, W; Kittner, H; Regenthal, R; Russo, E, 2004) |
| " In five multiple-dose studies in healthy subjects (n=82) and epilepsy patients (n=86) the estimates of divalproex-ER/divalproex ratios for steady-state 24 h valproic acid area under the curve (AUC) central values, maximum concentration (C(max)) central values and minimum concentration (C(min)) means had ranges of 0." | 3.72 | Bioavailability of divalproex extended-release formulation relative to the divalproex delayed-release formulation. ( Dutta, S; Zhang, Y, 2004) |
| " After adjustment for prior fracture, use (ever) of corticosteroids, comorbidity, social variables, and diagnosis of epilepsy, carbamazepine [CBZ; odds ratio (OR), 1." | 3.72 | Fracture risk associated with use of antiepileptic drugs. ( Mosekilde, L; Rejnmark, L; Vestergaard, P, 2004) |
| "In the past 6 years, 11 children on valproic acid have developed pancreatitis in our children's hospital." | 3.72 | Valproic acid-induced pancreatitis in childhood epilepsy: case series and review. ( Berg, M; Breault, R; Sinclair, DB, 2004) |
| "The study aimed at a comparative analysis of safety and efficacy of valproic acid (valproate) and barbiturates in the treatment of epilepsy in children." | 3.72 | [Efficacy and safety of antiepileptic therapy in children (a comparative analysis of valproates and barbiturates)]. ( Petrukhin, AS; Pylaeva, OA; Voronkova, KV, 2004) |
| " Valproic acid (VPA) is a very effective anticonvulsant agent widely used in the management of various forms of epilepsy." | 3.72 | Effect of long-term therapy with sodium valproate on nail and serum trace element status in epileptic children. ( Akyol, O; Armutcu, F; Gurel, A; Kanter, M; Ozerol, E; Vural, H; Yakinci, C, 2004) |
| "Valproic acid is increasingly used in the treatment of epilepsy, and also prescribed for bipolar affective disorders, schizoaffective disorders, schizophrenia and migraine prophylaxis." | 3.72 | Valproic acid intoxication: sense and non-sense of haemodialysis. ( Boerma, EC; Broekroelofs, J; Egbers, PH; Meek, MF; van der Voort, PH; Yska, JP, 2004) |
| "In order to investigate the possible role of valproic acid therapy in the development of obesity, hyperinsulinism and polycystic ovaries (PCOs), we have studied metabolic parameters and ovarian morphology in epileptic women." | 3.71 | Polycystic ovaries, obesity and insulin resistance in women with epilepsy. A comparative study of carbamazepine and valproic acid in 105 women. ( Abraham, I; Alge, A; Bauer, G; Haslinger, M; Lechleitner, M; Luef, G; Seppi, K; Trinka, E; Unterberger, I; Windisch, J, 2002) |
| "The aim of this study was to obtain a pharmacokinetic calculation for valproic acid (VPA) and its free fraction in 50 children and adolescents (4-18 years) treated for epilepsy in VPA monotherapy and bitherapy with carbamazepine (CBZ)." | 3.71 | Studies on the pharmacokinetics of total and free valproate in mono- and bitherapy with carbamazepine in epileptic children and adolescents. ( Galas-Zgorzalewicz, B; Steinborn, B, 2002) |
| "In this study, serum triglyceride, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), vitamin B12 and folic acid levels were studied in children with epilepsy who had been receiving long-term valproate (VPA) therapy." | 3.71 | Serum lipids, vitamin B12 and folic acid levels in children receiving long-term valproate therapy. ( Caksen, H; Geda, G; Içağasioğlu, D, 2002) |
| " A cohort study comparing life expectancy of males and females with cerebral palsy and a systematic review of five trials comparing two anti-epileptic drugs, carbamazepine and sodium valproate, are used for illustration." | 3.71 | Aggregate data meta-analysis with time-to-event outcomes. ( Hutton, JL; Marson, AG; Smith, CT; Williamson, PR, 2002) |
| "In this experiment, we studied the effect of valproate (VPA) on weight gain, and serum leptin levels in prepubertal epileptic children receiving VPA." | 3.71 | Does long-term use of valproate cause weight gain in prepubertal epileptic children? ( Berberoğlu, M; Caksen, H; Deda, G, 2002) |
| "In this study, we studied serum calcium, phosphorus, alkaline phosphatase, thyroid hormones (total thyroxine, free thyroxine, thyroid-stimulating hormone), parathyroid hormone, and osteocalcine levels in children with epilepsy who had been receiving long-term valproate (VPA) therapy in order to determine whether there was any effect of VPA therapy on these hormones." | 3.71 | No effect of long-term valproate therapy on thyroid and parathyroid functions in children. ( Ataş, B; Caksen, H; Cesur, Y; Dülger, H; Odabaş, D; Tuncer, O, 2002) |
| " Patients with high-grade gliomas were treated with up-front chemotherapy regimen consisting of fotemustine (d3: 100 mg/m2), cisplatin (d1-3: 33 mg/m2) and etoposide (d1-3: 75 mg/m2) followed by whole brain radiotherapy at progression." | 3.71 | Nitroso-urea-cisplatin-based chemotherapy associated with valproate: increase of haematologic toxicity. ( Bourg, V; Chichmanian, RM; Frenay, M; Lebrun, C; Thomas, P, 2001) |
| "A 15-year-old boy with epilepsy and cerebral calcifications, treated with valproic acid, ethyl phenylbarbiturate and ethosuximide, was referred for drug induced systemic lupus erythematosus." | 3.71 | Latent coeliac disease in a child with epilepsy, cerebral calcifications, drug-induced systemic lupus erythematosus and intestinal folic acid malabsorption associated with impairment of folic acid transport across the blood-brain barrier. ( Calvani, M; Guaitolini, C; Paolone, G; Parisi, G; Parisi, P, 2001) |
| "Perimenstrual catamenial epilepsy may in part be due to withdrawal of the endogenous progesterone-derived neurosteroid allopregnanolone that potentiates gamma-aminobutyric acidA (GABA(A)) receptor-mediated inhibition." | 3.71 | Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy. ( Reddy, DS; Rogawski, MA, 2001) |
| "It is not known whether polytherapy with carbamazepine (CBZ) and valproate (VPA) increases the risk of thrombocytopenia." | 3.71 | Severe, isolated thrombocytopenia under polytherapy with carbamazepine and valproate. ( Finsterer, J; Hess, B; Pelzl, G, 2001) |
| "Carbamazepine and valproic acid are effective antiepileptic drugs for treating many types of epilepsy." | 3.71 | Thyroid hormones in epileptic children receiving carbamazepine and valproic acid. ( Basciani, F; Chiarelli, F; Morgese, G; Morresi, S; Verrotti, A, 2001) |
| " This study aimed to evaluate thyroid function in men taking carbamazepine (CBZ), oxcarbazepine (OCBZ), or valproate (VPA) for epilepsy." | 3.71 | Thyroid function in men taking carbamazepine, oxcarbazepine, or valproate for epilepsy. ( Isojärvi, JI; Kotila, M; Myllylä, VV; Pakarinen, AJ; Rättyä, J; Turkka, J, 2001) |
| "Long-term treatment with valproate (VPA) or carbamazepine (CBZ) may induce reproductive endocrine disorders in patients with epilepsy." | 3.71 | Early hormonal changes during valproate or carbamazepine treatment: a 3-month study. ( Isojärvi, JI; Knip, M; Myllylä, VV; Pakarinen, AJ; Rättyä, J; Repo-Outakoski, M, 2001) |
| "To determine whether long-term treatment with valproate (VPA) and/or lamotrigine (LTG) in children with epilepsy is associated with altered growth and/or bone metabolism." | 3.71 | Long-term valproate and lamotrigine treatment may be a marker for reduced growth and bone mass in children with epilepsy. ( Atkinson, SA; Guo, CY; Ronen, GM, 2001) |
| "To examine bone development in children and adolescents who have uncomplicated idiopathic epilepsy and had received monotherapy with carbamazepine or valproic acid for at least 1 year." | 3.71 | Analysis of the musculoskeletal system in children and adolescents receiving anticonvulsant monotherapy with valproic acid or carbamazepine. ( Herkenrath, P; Rauch, F; Rieger-Wettengl, G; Schauseil-Zipf, U; Schoenau, E; Stabrey, A; Tutlewski, B, 2001) |
| "Dynamics of carbamazepine and valproic acid concentrations in the middle of follicular and lutein menstrual cycle phases has been studied in women with epilepsy, aged 21-30 years." | 3.71 | [Pharmacokinetic aspects of carbamazepine and valproic acid using in reproductive-age women with epilepsy]. ( Karlov, VA; Sokolov, AV; Tishchenkova, IF; Vlasov, PN, 2002) |
| "Valproic acid is commonly used in the management of childhood epilepsy." | 3.71 | Coagulation abnormalities and acquired von Willebrand's disease type 1 in children receiving valproic acid. ( Kavakli, K; Serdaroglu, G; Tekgül, H; Tütüncüoglu, S, 2002) |
| "We present three children with severe therapy-refractory epilepsy who tolerated valproate (VPA) well in various combinations with other antiepileptic drugs (AEDs) but developed typical VPA side effects in combination with topiramate (TPM)." | 3.71 | Topiramate enhances the risk of valproate-associated side effects in three children. ( Koelfen, W; König, S; Longin, E; Teich, M, 2002) |
| " Leptin is considered a signaling factor regulating body weight and energy metabolism." | 3.71 | Serum insulin and leptin levels in valproate-associated obesity. ( Isojärvi, JI; Knip, M; Kotila, M; Pakarinen, A; Pylvänen, V; Turkka, J, 2002) |
| "Valproic acid is effective for treatment of many types of epilepsy, but its use in epileptic patients can be associated with an increase in body weight that could interfere with treatment compliance." | 3.71 | Insulin resistance in epileptic girls who gain weight after therapy with valproic acid. ( Basciani, F; Chiarelli, F; De Simone, M; Morgese, G; Trotta, D; Verrotti, A, 2002) |
| "To determine whether children with epilepsy undergoing valproate (VPA) antiepileptic therapy and who are otherwise healthy have a lower serum level of carnitine (CAR) and a higher plasma level of plasma ammonia than do normal children." | 3.70 | Valproate therapy does not deplete carnitine levels in otherwise healthy children. ( Hirose, S; Mitsudome, A; Muta, Y; Ogawa, A; Tomoda, Y; Yasumoto, S, 1998) |
| "To evaluate the interictal autonomic nervous system function in 84 patients with epilepsy: 37 with newly diagnosed, previously untreated epilepsy, and 47 patients receiving long-term carbamazepine (CBZ), phenytoin (PHT), or valproate (VPA) monotherapy, or CBZ plus PHT, or CBZ plus VPA for their seizure disorder." | 3.70 | Interictal cardiovascular autonomic responses in patients with epilepsy. ( Ansakorpi, H; Isojärvi, JI; Myllylä, VV; Repo, M; Suominen, K; Tolonen, U, 1998) |
| "In November 1996, a panel of pediatric neurologists met to update the consensus statement issued in 1989 by a panel of neurologists and metabolic experts on L-carnitine supplementation in childhood epilepsy." | 3.70 | L-carnitine supplementation in childhood epilepsy: current perspectives. ( Bohan, TP; Coulter, DL; De Vivo, DC; Dreifuss, FE; Greenwood, RS; Nordli, DR; Shields, WD; Stafstrom, CE; Tein, I, 1998) |
| "To review (retrospectively) the relationships between lamotrigine (LTG) dosage and plasma concentrations based on data generated in a routine therapeutic drug monitoring laboratory from a heterogeneous sample of patients with epilepsy." | 3.70 | Lamotrigine and therapeutic drug monitoring: retrospective survey following the introduction of a routine service. ( Batty, AB; Black, AB; Harris, AL; Morris, RG; Sallustio, BC, 1998) |
| "Forty girls taking valproate (VPA), 19 girls taking carbamazepine (CBZ), and 18 girls taking oxcarbazepine (OXC) for epilepsy and 49 healthy control girls participated in the study, which included a cross-sectional clinical examination when the girls were 8 to 18 years old and a longitudinal growth analysis from the age of 1 year." | 3.70 | The effects of valproate, carbamazepine, and oxcarbazepine on growth and sexual maturation in girls with epilepsy. ( Isojärvi, JI; Knip, M; Lanning, P; Rättyä, J; Vainionpää, L, 1999) |
| "A pregnant woman with epilepsy receiving VPA and ethosuximide (ESM) was given high-dose multivitamins from 13 to 28 weeks' gestation." | 3.70 | Valproate-induced biochemical abnormalities in pregnancy corrected by vitamins: a case report. ( Baggot, PJ; Kalamarides, JA; Shoemaker, JD, 1999) |
| "A population analysis of the kinetics of valproic acid (VPA) in children with epilepsy was performed in order to characterize the covariates which influence VPA clearance (CL)." | 3.70 | Valproate population pharmacokinetics in children. ( Buelga, DS; Domínguez-Gil, A; García Sánchez, MJ; Otero, MJ; Serrano, BB; Serrano, J, 1999) |
| "Neural tube defects (NTDs) are the most common of the major anomalies associated with in utero exposure to valproic acid." | 3.70 | Safe use of valproic acid during pregnancy. ( Kennedy, D; Koren, G, 1999) |
| "Weight gain has been recognized as an adverse effect of valproic acid therapy, but there are are no data about serum leptin levels in patients receiving this drug." | 3.70 | Serum leptin changes in epileptic patients who gain weight after therapy with valproic acid. ( Basciani, F; Chiarelli, F; de Martino, M; Morgese, G; Morresi, S; Verrotti, A, 1999) |
| "We previously encountered a patient with epilepsy who exhibited rapid elimination of sustained-release valproic acid (VPA) administered at the dose of 2." | 3.70 | Valproic acid elimination rate and urinary excretion of its glucuronide conjugate in patients with epilepsy. ( Akiyama, T; Hayashi, T; Hirozane, K; Kamiya, A; Katayama, H; Kimoto, H; Watanabe, M; Yoshida, H; Yoshitomi, H, 1999) |
| "We determined serum levels of triiodothyronine (T3), thyroxine (T4), free thyroxine (FT4), thyroxine-binding globulin (TBG), and thyroid-stimulating hormone (TSH) in 148 healthy children and 141 children with epilepsy who had been receiving CBZ (61 patients), VPA (51 patients), or PB (29 patients) for 12-161 months." | 3.70 | Long-term treatment of children with epilepsy with valproate or carbamazepine may cause subclinical hypothyroidism. ( Castro-Gago, M; Del Río-Garma, M; Del Río-Garma, MC; Eirís-Puñal, J; Lojo-Rocamonde, S; Novo-Rodríguez, I, 1999) |
| "Two adult patients with focal epilepsy who tolerated valproate (VPA) well in different combinations of anticonvulsants developed hyperammonemic encephalopathy when treated with VPA in combination with topiramate (TPM)." | 3.70 | Valproate-induced hyperammonemic encephalopathy in the presence of topiramate. ( Hamer, HM; Knake, S; Rosenow, F; Schomburg, U, 2000) |
| "A 24-years-old woman with epilepsy treated with valproic acid developed disorientation, acalculia, perseveration, slow responsiveness and loss of memory." | 3.70 | [A case report of valproate encephalopathy]. ( Hirata, K; Katayama, S; Miyamoto, M; Miyamoto, T, 1999) |
| " We report two cases of an adverse effect of dyskinesia and bruxism when MPH was given to children maintained on valproic acid." | 3.70 | Adverse response to methylphenidate in combination with valproic acid. ( Gara, L; Roberts, W, 2000) |
| "Our data indicate that not only fasting but also 6h-PML tHcy levels should be determined in order to identify hyperhomocysteinemia among patients on AEDs." | 3.70 | Homocysteine concentrations and methionine loading in patients on antiepileptic drugs. ( Apeland, T; Kristensen, O; Mansoor, MA; Strandjord, RE, 2000) |
| "Perimenstrual catamenial epilepsy, the exacerbation of seizures in association with menstruation, may in part be due to withdrawal of the progesterone metabolite allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one), an endogenous anticonvulsant neurosteroid that is a positive allosteric modulator of gamma-aminobutyric acid(A) receptors." | 3.70 | Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy. ( Reddy, DS; Rogawski, MA, 2000) |
| "Twenty epileptic women were treated with valproate only during pregnancy and two were treated with valproate and carbamazepine." | 3.70 | Neonatal hypoglycaemia and withdrawal symptoms after exposure in utero to valproate. ( Ebbesen, F; Holsteen, V; Hoseth, E; Joergensen, A; Kaad, PH; Moeller, M; Rix, M, 2000) |
| " The fact that valproic acid, a derivative of pentanoic acid, also induces gamma-globin expression suggests that short-chain fatty acid derivatives that are already approved for human use may possess the property of gamma-globin inducibility and may be of therapeutic relevance to the beta-chain hemoglobinopathies." | 3.69 | Stimulation of fetal hemoglobin production by short chain fatty acids. ( Blau, CA; Dover, G; Fournarakis, B; Josephson, B; Li, Q; Liakopoulou, E; Papayannopoulou, T; Raisys, V; Stamatoyannopoulos, G; Wolf, JA, 1995) |
| "Axial (second, third, and fourth lumbar vertebrae) and appendicular (distal third of radius) bone mineral density was measured by dual-energy x-ray absorptiometry in 27 healthy children and 26 children with uncomplicated idiopathic epilepsy treated with either carbamazepine (n = 13) or valproate (n = 13) for more than 18 months." | 3.69 | Effect of carbamazepine and valproate on bone mineral density. ( Bodensteiner, JB; Hobbs, GR; Jacob, JC; Penney, S; Riggs, JE; Sheth, RD; Wesolowski, CA, 1995) |
| "A girl with intractable epilepsy who received high dose valproic acid showed bone marrow suppression, which improved after the end of valproic acid treatment and the administration of supportive treatments." | 3.69 | Bone marrow suppression induced by high dose valproic acid. ( Fujita, N; Ishimae, M; Kawaguchi, H; Kishi, T; Tanaka, T; Watanabe, K, 1994) |
| "We report a newborn with isolated aplasia cutis congenita of the scalp whose mother was treated with valproic acid during pregnancy." | 3.69 | Aplasia cutis congenita of the scalp in an infant exposed to valproic acid in utero. ( Berthier, M; Bonneau, D; Couet, D; Hubert, A; Larrègue, M; Oriot, D, 1994) |
| "Three patients who developed chorea during long-term treatment with valproic acid." | 3.69 | Choreiform movements associated with the use of valproate. ( Asconapé, JJ; Lancman, ME; Penry, JK, 1994) |
| "Chemotherapy with a combination of synthetic ACTH (ACTH-Zn) and valproic acid (VPA) induced remarkable hypofibrinogenemia in three children (5 months, 8 months, and 5 years and 10 months old) with intractable epilepsy." | 3.69 | [Three cases of hypofibrinogenemia induced by chemotherapy with a combination of synthetic ACTH and valproic acid]. ( Kodani, N; Ogino, T; Tokuda, K, 1994) |
| "To evaluate the population pharmacokinetics of valproic acid in children, 97 steady-state serum valproate concentration measurements were gathered during normal, routine, outpatient care of 52 children with epilepsy (1." | 3.69 | A model for estimating individualized valproate clearance values in children. ( Botha, JH; Gray, AL; Miller, R, 1995) |
| "The interaction between clearance of phenytoin, valproic acid, phenobarbital and carbamazepine, and changes in body weight was determined in a 19-year-old obese woman with epilepsy (body weight 93 kg, BMI 36." | 3.69 | Clearance of phenytoin and valproic acid is affected by a small body weight reduction in an epileptic obese patient: a case study. ( Ashikari, Y; Chiba, S; Kodama, Y; Kuranari, M; Sakata, T; Takeyama, M, 1996) |
| "This study was performed to evaluate the aggregation changes in the whole blood samples of children with epilepsy receiving valproic acid." | 3.69 | The platelet aggregation in children with epilepsy receiving valproic acid. ( Akin, R; Gokcay, E; Koseoglu, V; Kurekci, AE; Ozcan, O; Tanindi, S, 1996) |
| "Because binding of valproic acid to plasma proteins affects the efficacy of the drug in the treatment of epilepsy (only the unbound fraction of the drug is effective) we have compared two methods which use different binding parameters to predict the in-vivo concentration of unbound valproic acid in serum." | 3.69 | Comparison of two binding equations for prediction of the concentration of unbound valproic acid in the serum of adult epileptic polytherapy patients. ( Fujii, I; Kodama, H; Kodama, Y; Kuranari, M; Takeyama, M; Yukawa, E; Zaizen, T, 1996) |
| "Twelve women receiving stable valproic acid (VPA) monotherapy for epilepsy received a combination norethindrone 1." | 3.69 | Effect of topiramate on the pharmacokinetics of an oral contraceptive containing norethindrone and ethinyl estradiol in patients with epilepsy. ( Doose, DR; Nayak, RK; Rosenfeld, WE; Walker, SA, 1997) |
| "We report the effects of two new dihydropyridine derivatives, isradipine (4-(4'-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedic arboxylic acid methylisopropylester) and niguldipine (1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid 3-(4,4-diphenyl-1-piperidinyl)-propyl methyl ester hydrochloride), and of dantrolene (1-[(5-[p-nitrophenyl]furfurylidene)-amino]hydantoin sodium, an inhibitor of Ca2+ release from intracellular stores) on the protective efficacy of antiepileptic drugs against maximal electroshock-induced seizures." | 3.69 | Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice. ( Borowicz, KK; Czuczwar, SJ; Gasior, M; Kleinrok, Z, 1997) |
| " Eighty patients presenting with epilepsy received monotherapies of valproic acid, phenytoin, or carbamazepine; 18 patients did not receive antiepileptic drug therapy." | 3.69 | Color vision tests for early detection of antiepileptic drug toxicity. ( Bayer, AU; Dichgans, J; Kuehn, M; Paulus, W; Ried, S; Schmidt, D; Thiel, HJ; Zrenner, E, 1997) |
| "Serum lipids were determined in 10 untreated patients with recently diagnosed epilepsy, 21 patients treated with carbamazepine (CBZ), 10 patients treated with valproate (VPA) and in 15 healthy children." | 3.69 | The effects of long-term anticonvulsive treatment on serum lipid profile. ( Hassanzadeh, A; Mawlud, K; Yalçin, E, 1997) |
| "Serum total cholesterol (TC), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C) and very low-density lipoprotein cholesterol, triglyceride, apolipoproteins A1 and B levels were studied in 57 healthy children and in 39 children with epilepsy who had been receiving carbamazepine (CBZ) (23 children) for 1." | 3.69 | Serum lipids in epileptic children treated with carbamazepine and valproate. ( Arpaci, B; Atakil, D; Baybas, S; Dogu, O; Sözüer, DT, 1997) |
| "Auditory event related potentials were recorded in 40 patients with idiopathic generalized epilepsy, 20 on monotherapy with sodium valproate (VPA), 20 on monotherapy with carbamazepine and 20 age and sex matched controls." | 3.69 | Auditory event related potentials in patients with epilepsy on sodium valproate monotherapy. ( Karageorgiou, CL; Panagopoulos, GR; Tagaris, G; Thomaides, T, 1997) |
| " The multiple peak approach has been used to evaluate the effect of age, total body weight, dose, gender and comedication (carbamazepine-induced change) on population estimates of valproic acid relative clearance." | 3.69 | Detection of carbamazepine-induced changes in valproic acid relative clearance in man by simple pharmacokinetic screening. ( Aoyama, T; Higuchi, S; Honda, T; Ohdo, S; Yukawa, E, 1997) |
| "Very little data are available on the usefulness of oxcarbazepine in young children with epilepsy." | 3.69 | Oxcarbazepine in the treatment of early childhood epilepsy. ( Gaily, E; Granström, ML; Liukkonen, E, 1997) |
| "Nonlinear mixed effects modeling (NONMEM) was used to estimate the effects of drug-drug interaction on valproic acid relative clearance values using 792 serum levels gathered from 400 pediatric and adult patients with epilepsy (age range, 0." | 3.69 | Population-based investigation of valproic acid relative clearance using nonlinear mixed effects modeling: influence of drug-drug interaction and patient characteristics. ( Aoyama, T; Higuchi, S; Ohdo, S; To, H; Yukawa, E, 1997) |
| "Information from standardised tests of intelligence, school attainments, attention, memory and visuomotor function, together with parent and teacher questionnaire information about various aspects of behaviour, was obtained for 63 schoolchildren with newly diagnosed epilepsy before treatment with sodium valproate or carbamazepine, and again at intervals for a total period of 12 months." | 3.68 | Psychological effects of sodium valproate and carbamazepine in epilepsy. ( Stores, G; Styles, E; Williams, PL; Zaiwalla, Z, 1992) |
| "We retrospectively collected plasma level assessments performed in 96 adult patients with epilepsy on stable monotherapy, including 9 patients on clobazam (CLB), 34 on carbamazepine (CBZ), 24 on phenobarbital (PB), 9 on phenytoin (PHT), and 20 on valproate (VPA); these results were compared to those obtained in 54 adult patients on stable bitherapy with the association of CLB with either CBZ (n = 17), PB (n = 17), PHT (n = 5), or VPA (n = 15)." | 3.68 | Interactions between clobazam and standard antiepileptic drugs in patients with epilepsy. ( Bonneton, J; Dravet, C; Genton, P; Mesdjian, E; Roger, J; Sennoune, S, 1992) |
| " Spina bifida aperta has been linked specifically to valproic acid (VPA) (estimated risk, 1 to 2%)." | 3.68 | The risk of spina bifida aperta after first-trimester exposure to valproate in a prenatal cohort. ( Brandenburg, H; Gaillard, HL; Grobbee, DE; Jahoda, MG; Los, FJ; Omtzigt, JG; Pijpers, L; Sachs, ES; Stewart, PA; Wladimiroff, JW, 1992) |
| "We report the case of a young man suffering from epilepsy who developed chronic calcified pancreatitis after ten years of therapy with the anticonvulsant drugs carbamazepine and phenytoin." | 3.68 | Anticonvulsant-induced chronic pancreatitis. A case report. ( Billi, P; Broccoli, PL; Fontana, G; Melandri, R; Pezzilli, R, 1992) |
| "In newly diagnosed adult patients with epilepsy followed prospectively on monotherapy, carbamazepine and phenytoin were associated with a fall in plasma uric acid, but sodium valproate and phenobarbitone were associated with a rise in plasma uric acid." | 3.68 | Plasma uric acid in patients receiving anticonvulsant monotherapy. ( Heller, AJ; Johnson, AL; Marshall, WJ; Reynolds, EH; Ring, HA, 1991) |
| "The effects of antiepileptic drugs (AED) on infants during pregnancy and delivery were studied in a total of 82 epileptic mothers on various monotherapies; 29 cases receiving valproic acid (VPA), 20 receiving phenytoin (PHT), 18 on carbamazepine (CBZ) and 15 on phenobarbital (PB)." | 3.68 | [Effects of antiepileptic drugs on delivery and early childhood--comparison among mono-therapies of valproic acid, phenytoin, carbamazepine and phenobarbital]. ( Ishikawa, S; Izumi, M; Okada, H; Takeda, A; Tanaka, H, 1991) |
| "The case of a mentally handicapped female patient is presented who developed typical pellagra with dermatitis, diarrhoea and mental alteration following a long-term antiepileptic treatment with phenytoin, ethosuximide and valproic acid." | 3.68 | [Pellagra in anticonvulsive therapy]. ( Bartels, H; Hebestreit, H; Mingers, AM; Pannenbecker, J, 1990) |
| "Oxiracetam, a nootropic drug, could be of potential use in the treatment of memory disturbances in patients with epilepsy who are using antiepileptic drugs." | 3.68 | Pilot study to determine the interaction of oxiracetam with antiepileptic drugs. ( Meijer, JW; van Emde Boas, W; van Wieringen, A; Vermeij, TA, 1990) |
| " This is a syndrome of idiopathic generalized epilepsy that responds to treatment with valproic acid." | 3.68 | Eyelid twitching seizures and generalized tonic-clonic convulsions: a syndrome of idiopathic generalized epilepsy. ( Ferrendelli, JA; Miller, JW, 1990) |
| "Free and total carbamazepine (CBZ) and carbamazepine-epoxide (CBZ-EP) plasma levels were obtained on 113 patients with epilepsy (18-61 years old) controlled on either monotherapy or coadministration with either phenobarbital (PB), phenytoin (PHT), valproic acid (VPA), or all three." | 3.68 | Carbamazepine metabolism in humans: effect of concurrent anticonvulsant therapy. ( Briggle, TV; Guterman, A; McManus, DQ; Perchalski, R; Ramsay, RE; Vazquez, D; Wong, P; Yost, RA, 1990) |
| "An infant with dysmorphic features was born to an epileptic mother who had taken phenytoin and sodium valproate throughout pregnancy." | 3.68 | Neocerebellar hypoplasia in a neonate following intra-uterine exposure to anticonvulsants. ( Hope, PL; Lindenbaum, RH; Squier, W, 1990) |
| "The anticonvulsant potency of 2-propyl-2-pentenoic acid (2-en-VPA; trans isomer), a major metabolite of the antiepileptic valproic acid (VPA), was evaluated in different animal models of epilepsy and compared with the respective data for VPA." | 3.67 | Comparative evaluation of anticonvulsant and toxic potencies of valproic acid and 2-en-valproic acid in different animal models of epilepsy. ( Löscher, W; Marescaux, C; Nau, H; Vergnes, M, 1984) |
| "Using mobile long-term electroencephalographic (EEG) monitoring in 7 absence epilepsy patients, the course of spike-wave discharge rate before and during valproate monotherapy was measured and compared to the profile of valproic acid serum level." | 3.67 | Lack of significant correlation between circadian profiles of valproic acid serum levels and epileptiform electroencephalographic activity. ( Burr, W; Froescher, W; Hoffmann, F; Stefan, H, 1984) |
| "A total of 64 problem patients with epilepsy (42 retrospective evaluations, 22 prospective cases) was treated with the combination of carbamazepine and valproic acid." | 3.67 | [Combination therapy with carbamazepine and valproic acid in problem cases at an outpatient epilepsy clinic]. ( Fröscher, W; Hoffmann, F; Stoll, KD, 1984) |
| "A method of measuring carbamazepine-10,11-epoxide (CBZ-10,11-EPOX) has been developed and used to monitor plasma concentrations in children suffering from various forms of epilepsy." | 3.67 | Altered ratio of carbamazepine-10,11-epoxide/carbamazepine in plasma of children: evidence of anticonvulsant drug interaction. ( Brett, EM; Elyas, AA; Lascelles, PT; Schoeman, JF, 1984) |
| "Ninety children with epilepsy were treated with carbamazepine (CBZ) alone or with other anticonvulsant drugs." | 3.67 | Correlation between plasma carbamazepine-10,11-epoxide concentration and drug side-effects in children with epilepsy. ( Brett, EM; Elyas, AA; Lascelles, PT; Schoeman, JF, 1984) |
| "A 20-month-old boy with absence epilepsy was found to have a strikingly elevated serum alkaline phosphatase (AP) at start of treatment with valproic acid." | 3.67 | Dynamic aspects in transient hyperphosphatasaemia of infancy. ( Carstensen, H; Rasmussen, KT, 1988) |
| "We have identified ten children who developed gastritis after prolonged anticonvulsant therapy that included either valproic acid or divalproex sodium." | 3.67 | Gastritis with valproate therapy. ( Bobele, GB; Bodensteiner, JB; Grunow, JE; Hille, MR; Marks, WA; Morris, MP; Tuggle, D, 1988) |
| "Fetal exposure to valproic acid has recently been associated with an increased incidence of neural tube defects." | 3.67 | Prenatal detection of a neural tube defect after fetal exposure to valproic acid. ( Campbell, WA; Cassidy, SB; Ciarleglio, L; Nochimson, DJ; Vintzileos, AM; Weinbaum, PJ, 1986) |
| "We studied 85 pediatric patients with different types of epilepsy treated with valproic acid." | 3.67 | Valproic acid in the treatment of epilepsy during the pediatric age. ( Olmos-Garcia de Alba, G; Valdez, JM, 1986) |
| "The association of fetal and neonatal distress, birth measurements, major malformations, and minor anomalies was studied prospectively in 14 infants of women with epilepsy who were receiving valproic acid (VPA) monotherapy and in 12 infants of women with epilepsy who were receiving VPA in combination with other anticonvulsant drugs." | 3.67 | Fetal growth, major malformations, and minor anomalies in infants born to women receiving valproic acid. ( Deichl, A; Hartmann, AM; Helge, H; Jäger-Roman, E; Jakob, S; Koch, S; Nau, H; Rating, D; Steldinger, R, 1986) |
| "Three drugs which increase GABA-mediated inhibitory neurotransmission in the brain, namely the GABA degradation inhibitors aminooxyacetic acid (AOAA) and gamma-acetylenic GABA (GAG), and the GABA receptor agonist THIP (gaboxadol), were administered to epilepsy-prone gerbils via subcutaneously implanted osmotic minipumps for 2 weeks." | 3.67 | Development of tolerance to the anticonvulsant effect of GABAmimetic drugs in genetically epilepsy-prone gerbils. ( Löscher, W, 1986) |
| "In six patients with epilepsy and fibrocystic breast disease the concentration in serum of antiepileptic drugs was obtained before, during, and after danazol therapy." | 3.67 | Clinically significant danazol-carbamazepine interaction. ( Haidukewych, D; Lichten, EM; Zielinski, JJ, 1987) |
| "To assess the most efficient means of monitoring thyroid status in an epilepsy clinic, total thyroxine (T4), free thyroxine stimulating hormone (TSH) were measured in 71 adult patients treated long-term with either phenytoin (DPH), carbamazepine (CBZ) or sodium valproate (VAL)." | 3.67 | The effective evaluation of thyroid status in patients on phenytoin, carbamazepine or sodium valproate attending an epilepsy clinic. ( Borsey, DQ; Browning, MC; Connacher, AA; Davidson, DL; Jung, RT, 1987) |
| "In a survey of the red cell folate status of 200 patients with epilepsy, compared to 72 controls, we found that median red cell folate levels were reduced significantly in patients treated with phenytoin (p less than 0." | 3.67 | A comparative study of the relative effects of anticonvulsant drugs and dietary folate on the red cell folate status of patients with epilepsy. ( Baker, M; Bissessar, A; Callaghan, N; Crowley, M; Goggin, T; Gough, H, 1987) |
| "Neural tube, craniofacial, and other congenital abnormalities have been described in infants born to mothers with epilepsy who were treated with valproic acid (VPA) during pregnancy." | 3.67 | Congenital abnormalities in two sibs exposed to valproic acid in utero. ( Anderson, L; Chitayat, D; Farrell, K; Hall, JG, 1988) |
| "The Comprehensive Epilepsy Program of Minnesota database was searched for patients who had no dose change of carbamazepine (CBZ), phenytoin (PHT) or valproate (VPA) for 3 consecutive visits." | 3.67 | Variability of phenytoin, carbamazepine and valproate concentrations in a clinic population. ( Leppik, IE, 1988) |
| "After treatment with valproic acid a 19-year-old female patient with Friedreich's ataxia and generalised epilepsy died following acute hepatic failure with massive lactacidosis." | 3.67 | [Acute liver necrosis caused by valproate]. ( Hackenberg, K; Rengeling, M; Rühl, G; Zäh, W, 1985) |
| "The EEGs of 16 newly diagnosed children with primary generalized epilepsy were examined before and during up to 3 years of antiepileptic therapy with valproic acid." | 3.67 | Spectral analysis of the EEG in children during the introduction of antiepileptic therapy with valproic acid. ( Benninger, C; Matthis, P; Scheffner, D, 1985) |
| "The purpose of the follow-up study was to determine whether modern therapy with ethosuximide and/or valproate with/without phenobarbitone and its derivatives improves the longterm prognosis of absence epilepsy as compared to formerly used treatments." | 3.67 | Longterm follow-up of childhood epilepsy with absences. I. Epilepsy with absences at onset. ( Baier, WK; Dieterich, E; Doose, H; Fichsel, H; Tuxhorn, I, 1985) |
| "A total of 20 children with various types of epilepsy were treated with valproate, 11 with monotherapy and 9 with valproate in combination with phenobarbitone, phenytoin, or carbamazepine." | 3.66 | Plasma concentrations of valproate during maintenance therapy in epileptic children. ( Boréus, LO; Lundberg, B; Nergårdh, A, 1982) |
| " The present study comprised 31 patients with newly diagnosed epilepsy, commencing treatment with either carbamazepine or valproate." | 3.66 | Serum thyroid hormones and blood folic acid during monotherapy with carbamazepine or valproate. A controlled study. ( Bentsen, KD; Gram, L; Veje, A, 1983) |
| "The problem of phenytoin-induced gingival hyperplasia is dicussed within the context of consultative planning between oral care practitioners and the physician managing the epilepsy." | 3.66 | Therapeutic alternatives in phenytoin-induced gingival hyperplasia. A case report and discussion. ( Kirkham, DB; Reynolds, NC, 1980) |
| "Two patients treated with valproic acid developed stomatitis, which was not dose-related and cleared promptly after the drug was stopped." | 3.66 | Valproate-induced stomatitis. ( Russo, LS, 1981) |
| "Sodium valproate is often used with phenytoin when epilepsy cannot be controlled by a single drug." | 3.66 | Phenytoin-valproate interaction: importance of saliva monitoring in epilepsy. ( Hamshaw-Thomas, A; Knott, C; Reynolds, F, 1982) |
| "In 12 institutionalized epilepsy patients who had been treated 19 months (SD +/- 5) with valproic acid, 27." | 3.66 | Serial free and plasma valproic acid and phenytoin monitoring and drug interactions. ( Haidukewych, D; Rodin, EA, 1981) |
| "Valproic acid (VPA) was determined by EMIT assay in plasma, tears, saliva, and cerebrospinal fluid (CSF) of patients with epilepsy." | 3.66 | The free fraction of valproic acid in tears, saliva, and cerebrospinal fluid. ( Mastropaolo, C; Monaco, F; Mutani, R; Piredda, S; Tondi, M, 1982) |
| "During the course of a prospective serial study over a period of one year, findings compatible with immune-mediated thrombocytolysis accompanied the administration of valproic acid in about half of 45 children with epilepsy." | 3.66 | Valproic acid and immune thrombocytopenia. ( Barr, RD; Copeland, SA; Kelton, JC; Morris, N; Stockwell, ML, 1982) |
| "The authors studied antipyrine disposition before and after delivery in 4 epileptic women whose anticonvulsant plasma level per dosage ratio was lowered during pregnancy, and compared the results to those found in nonpregnant women undergoing antiepileptic treatment (N = 6) and healthy women (N = 6)." | 3.66 | Antipyrine disposition in relation to lowered anticonvulsant plasma level during pregnancy. ( Chiba, K; Ishizaki, T; Nakazawa, Y; Tabuchi, T; Wagatsuma, T, 1982) |
| "The side effects and possible side effects of the therapy with valproic acid were documented in 66 outpatients with epilepsy over a period of one year." | 3.66 | [Antiepileptic therapy with valproinic acid. Correlations of side effects and serum levels of valproinic acid]. ( Fröscher, W; Gugler, R; Schulz, HU, 1979) |
| "Sodium valproate and ethosuximide are anticonvulsants employed in the treatment of petit mal epilepsy; both drugs are considered to be thalamically active." | 3.66 | Effects of valproate and ethosuximide on thalamocortical excitability. ( Englander, RN; Hanna, GR; Johnson, RN; Nowack, WJ, 1979) |
| "Of 88 patients with intractable epilepsy, 60 have been treated with clonazepam for up to three years and 60 have been treated with sodium valproate for up to 18 months." | 3.65 | Sodium valproate and clonazepam in the treatment of intractable epilepsy. ( Anthony, M; Lance, JW, 1977) |
| " VPM summary of product characteristics and pharmacokinetic studies revealed a lower bioavailability (80% vs." | 3.01 | Valproate, divalproex, valpromide: Are the differences in indications justified? ( Besson, VC; Blaise, N; Bloch, V; Chouchana, M; Delage, C; Etain, B; Hagenimana, M; Palayer, M; Smati, J, 2023) |
| "Epilepsy is the most common symptom in patients with brain tumors." | 3.01 | Epilepsy and brain tumors: Two sides of the same coin. ( Aronica, E; Ciusani, E; Coppola, A; Costa, C; Maschio, M; Perversi, F; Russo, E; Salmaggi, A, 2023) |
| "The classification of seizure types and epilepsies should be examined before selecting the ASMs for each patient with epilepsy." | 3.01 | [Medical Treatment of Epilepsy]. ( Jin, K, 2023) |
| "Epilepsy is a group of neurological diseases characterized by susceptibility to recurrent seizures." | 3.01 | Management of epilepsy during pregnancy and lactation. ( Harris, KM; Hope, OA, 2023) |
| "The aims of the study were to develop a population pharmacokinetic model of orally administered brivaracetam in paediatric patients and to provide dosing suggestions." | 2.84 | Brivaracetam population pharmacokinetics in children with epilepsy aged 1 month to 16 years. ( Schoemaker, R; Stockis, A; Wade, JR, 2017) |
| "This study reviewed all published valproic acid (VPA) population pharmacokinetic (PPK) models in adult patients and assessed them using external validation methods to determine predictive performance." | 2.82 | Published population pharmacokinetic models of valproic acid in adult patients: a systematic review and external validation in a Chinese sample of inpatients with bipolar disorder. ( de Leon, J; Dong, F; Guo, W; Li, AN; Ruan, CJ; Zang, YN, 2022) |
| "Carbamazepine and phenytoin were the drugs most strongly associated with decreases in T4 and T3 levels while topiramate had the greatest elevating effect on TSH." | 2.82 | Side effects of long-term oral anti-seizure drugs on thyroid hormones in patients with epilepsy: a systematic review and network meta-analysis. ( Cai, M; Guo, X; Han, Y; Lin, W; Yang, J; Zhong, R, 2022) |
| "The phenytoin treatment causes cerebellar defect and anemia." | 2.82 | The interplay of epilepsy with impaired mitophagy and autophagy linked dementia (MAD): A review of therapeutic approaches. ( Agrawal, M; Dhurandhar, Y; Panda, SP, 2022) |
| "Although generalized convulsive status epilepticus (GCSE) is a life-threatening emergency, evidence-based data to guide initial drug treatment choices are lacking in the Chinese population." | 2.82 | Phenobarbital Versus Valproate for Generalized Convulsive Status Epilepticus in Adults: A Prospective Randomized Controlled Trial in China. ( Chen, W; Chun, B; Gao, D; Jiang, M; Liu, G; Ren, G; Su, Y; Tian, F; Ye, H; Zhang, Y, 2016) |
| "The LTG population pharmacokinetic model developed in this study may be a reliable method for individualising the LTG dosing regimen in paediatric and young adult patients on combination therapy during therapeutic drug monitoring." | 2.79 | Pharmacokinetics of lamotrigine in paediatric and young adult epileptic patients--nonlinear mixed effects modelling approach. ( Brzaković, B; Kovačević, SV; Martinović, Ž; Miljković, B; Pokrajac, M; Prostran, M; Vučićević, K, 2014) |
| " The validity of this approach remains uncertain and could be improved by understanding sources of pharmacokinetic variability." | 2.77 | Population pharmacokinetics of valproic acid in pediatric patients with epilepsy: considerations for dosing spinal muscular atrophy patients. ( Barrett, JS; Jayaraman, B; Swoboda, KJ; Williams, JH, 2012) |
| "Carbamazepine is a widely used anticonvulsive agent." | 2.76 | Effects of carbamazepine and metabolites on IL-2, IL-5, IL-6, IL-10 and IFN-γ secretion in epileptic patients: the influence of co-medication. ( Breton, H; Demoly, P; Gelisse, P; Hillaire-Buys, D; Mathieu, O; Picot, MC, 2011) |
| "No patient in the VPA group developed respiratory depression, hypotension, or hepatic dysfunction, whereas in the DZP group, 5." | 2.76 | Valproate versus diazepam for generalized convulsive status epilepticus: a pilot study. ( Chen, WB; Fan, CQ; Gao, R; Ren, Y; Su, YY; Wang, L; Zhang, YZ; Zhao, JW, 2011) |
| "Fifty-two patients with epilepsy of generalized seizures type were randomly divided into an ACCWM group (n=30) and a WM group (n=22)." | 2.76 | [Observation on therapeutic effect of acupoint catgut-embedding combined western medicine for epilepsy of generalized seizures type]. ( Gao, ZG; Mao, ZN; Wang, SB; Zhang, GW, 2011) |
| "To assess changes in seizure frequency, medication side-effects (especially tremor) and formulation preference after switching patients overnight from immediate-release to extended-release divalproex sodium." | 2.74 | Seizure control and side-effect profile after switching adult epileptic patients from standard to extended-release divalproex sodium. ( Brannegan, RT; Evans, AT; Pierre-Louis, SJ, 2009) |
| " Only one adverse event was reported; a 9-year-old male experienced burning at the infusion site while receiving 660 mg intravenous valproate at 6 mg/kg per minute." | 2.73 | Safety of rapid intravenous valproate infusion in pediatric patients. ( Coots, BP; Morton, LD; O'Hara, KA; Pellock, JM, 2007) |
| "Rapid administration of undiluted valproate is safe and well tolerated at infusion rate up to 10 mg/kg/min and doses of up to 30 mg/kg." | 2.73 | Safety of rapid intravenous loading of valproate. ( Cofield, SS; Dutta, S; Faught, E; Knowlton, RK; Limdi, NA; Paige, AL; Ver Hoef, LW, 2007) |
| "Valproic acid is a widely used anticonvulsant drug with a broad therapeutic spectrum." | 2.73 | Inhibitory effect of valproic acid on cytochrome P450 2C9 activity in epilepsy patients. ( Babaoglu, MO; Bilir, E; Bozkurt, A; Gunes, A; Yasar, U; Zengil, H, 2007) |
| "The onset of epilepsy is most prevalent between 1 and 3 years of age; however, approximately 25% of patients developed epilepsy before one year of age." | 2.72 | Epilepsy in Angelman syndrome: A scoping review. ( Samanta, D, 2021) |
| "We systematically reviewed the existing literature on the cosmetic adverse effects of antiseizure medications (ASMs) in order to depict a clear picture of these unwanted side effects of ASMs with a particular attention to hair loss, hirsutism, acne, and gingival hyperplasia." | 2.72 | Cosmetic adverse effects of antiseizure medications; A systematic review. ( Asadi-Pooya, AA; Mirzaei Damabi, N; Rostaminejad, M; Zeraatpisheh, Z, 2021) |
| " The DFL for divalproex-ER dosed as a q12h regimen was 22% less than that for once-daily divalproex-ER (P=0." | 2.72 | Every-12-hour administration of extended-release divalproex in patients with epilepsy: impact on plasma valproic acid concentrations. ( Cavanaugh, JH; Dutta, S; Granneman, GR; Locke, C; Reed, RC, 2006) |
| "The goal of our study was to evaluate clinical and serum valproic acid concentration changes in patients following overnight conversion from delayed-release sodium valproate (VPA-DR) to the same daily dosage of extended-release sodium valproate (VPA-ER)." | 2.72 | Conversion from delayed-release sodium valproate to extended-release sodium valproate: initial results and long-term follow-up. ( Lehman, EB; McCabe, PH; McNew, CD; Michel, NC, 2006) |
| " The aims of our study were to evaluate whether color vision and macular function are impaired in epileptic adolescents, to study if the monotherapy with valproic acid (VPA) and carbamazepine (CBZ) can affect color vision and macular function and to determine the possible relationship between color vision, retinal function and antiepileptic drugs (AEDs) dosage and their serum concentrations." | 2.72 | Color vision and macular recovery time in epileptic adolescents treated with valproate and carbamazepine. ( Chiarelli, F; Gallenga, PE; Iannetti, P; Lobefalo, L; Spalice, A; Tocco, AM; Verrotti, A, 2006) |
| " Similar proportions of subjects in the two groups reported adverse events during or within 6 h following the first infusion." | 2.71 | Safety and tolerance of rapidly infused Depacon. A randomized trial in subjects with epilepsy. ( Cantrell, D; Cloyd, JC; Collins, SD; Naritoku, DK; Ramsay, RE; Sommerville, K; Walch, JK, 2003) |
| "The availability of an intravenous formulation now makes possible rapid administration of valproate (VPA) loading doses, but estimates of key VPA pharmacokinetic parameters in patients have limited the use of this approach." | 2.71 | Valproate unbound fraction and distribution volume following rapid infusions in patients with epilepsy. ( Cao, G; Cloyd, JC; Collins, SD; Dutta, S; Granneman, GR; Walch, JK, 2003) |
| " Patients were converted during an | 2.71 | Lamotrigine monotherapy compared with carbamazepine, phenytoin, or valproate monotherapy in patients with epilepsy. ( Hammer, AE; Kaminow, L; Schimschock, JR; Vuong, A, 2003) |
| " Reduction in VPA dosage in the third patient produced no improvement." | 2.71 | Reversible parkinsonism with normal beta-CIT-SPECT in patients exposed to sodium valproate. ( Clough, P; Duncan, S; Easterford, K; Fallon, K; Kellett, M, 2004) |
| " Pharmacokinetic parameters were determined by a noncompartmental method." | 2.71 | Topiramate pharmacokinetics in children with epilepsy aged from 6 months to 4 years. ( Bouhours, P; Chiron, C; d'Athis, P; Dulac, O; Echenne, B; Grinspan, A; Mikaeloff, Y; Pons, G; Rey, E; Soufflet, C; Vallée, L, 2004) |
| "The use of VPA in the treatment of epilepsy is not associated with visual field defects similar to vigabatrin, but may induce abnormalities in colour vision." | 2.71 | Visual function in epilepsy patients treated with initial valproate monotherapy. ( Kälviäinen, R; Mäntyjärvi, M; Rissanen, E; Sorri, I, 2005) |
| " We developed a simple dosing scheme using valproate sodium injection (VPA-IV) and divalproex sodium extended-release (VPA-ER) tablets to minimize the time required for initiation of therapy, without increasing the likelihood of seizures and adverse effects." | 2.71 | Successful initiation of combined therapy with valproate sodium injection and divalproex sodium extended-release tablets in the epilepsy monitoring unit. ( Boggs, JG; Preis, K, 2005) |
| "In an observational study under routine clinical setting data after administration of once daily evening dosing of valproate sustained release minitablets were recorded in 359 patients with epilepsy aged between 12 and 86 years." | 2.71 | [Valproate sustained release in the treatment of epilepsy]. ( Fraunberger, B; Stefan, H, 2005) |
| "Weight gain is a common side effect of valproate treatment." | 2.71 | Serum insulin, leptin, and neuropeptide y levels in epileptic children treated with valproate. ( Aydin, K; Bideci, A; Gucuyener, K; Okuyaz, C; Serdaroglu, A, 2005) |
| " The peak concentration (Cmax) of CZP and the time intervals from dosing to Cmax (Tmax) were 20." | 2.70 | Pharmacokinetic and pharmacodynamic effects of clonazepam in children with epilepsy treated with valproate: a preliminary study. ( Wang, L; Wang, XD, 2002) |
| "Valproic acid (VPA) is an effective antiepileptic drug (AED), which is associated with dose-related adverse reactions such as skin rash, hair loss (alopecia), etc." | 2.70 | Low serum biotinidase activity in children with valproic acid monotherapy. ( Karikas, GA; Regoutas, S; Schulpis, KH; Tjamouranis, J; Tsakiris, S, 2001) |
| "The present study evaluates effect of pharmacokinetic interaction between caffeine (300 mg) in three divided doses with sodium valproate (400 mg) and carbamazepine (200 mg) given as single doses, in normal human volunteers, using a open cross over design." | 2.69 | Influence of caffeine on pharmacokinetic profile of sodium valproate and carbamazepine in normal human volunteers. ( David, J; Joseph, T; Kulkarni, C; Vaz, J, 1998) |
| "The most important factor determining seizure recurrence was continued therapy, which was the case for barbiturates, phenytoin and valproate." | 2.69 | Does withdrawal of different antiepileptic drugs have different effects on seizure recurrence? Further results from the MRC Antiepileptic Drug Withdrawal Study. ( Chadwick, D, 1999) |
| " Two analyses of adverse events are presented: tolerability and safety." | 2.69 | Safety and tolerability of gabapentin as adjunctive therapy in a large, multicenter study. ( Bernstein, P; Faught, RE; Holmes, GL; Magnus-Miller, L; McLean, MJ; Morrell, MJ; Privitera, MD; Rose-Legatt, A; Willmore, LJ, 1999) |
| "To evaluate plasma homocysteine (Hcy) concentrations in children receiving sodium valproate (VPA) and carbamazepine (CBZ), monotherapy, in comparison with healthy control subjects and to determine the possible relationship between Hcy levels and dosage and plasma concentrations of the antiepileptic drugs." | 2.69 | Hyperhomocysteinemia in children treated with sodium valproate and carbamazepine. ( Chiarelli, F; Giuva, T; Morgese, G; Pascarella, R; Trotta, D; Verrotti, A, 2000) |
| " Adverse events, laboratory studies performed, and seizure activity were documented on case report forms." | 2.68 | Safety of intravenous valproate. ( Dean, C; Devinsky, O; Gates, J; Leppik, I; Pellock, JM; Ramsay, RE; Willmore, LJ, 1995) |
| "Lamotrigine was effective in all seizure types examined, particularly for typical and atypical absence seizures." | 2.68 | Lamotrigine for the treatment of epilepsy in childhood. ( Alving, J; Besag, FM; Dulac, O; Hosking, G; Spencer, SC; Wallace, SJ, 1995) |
| " Furthermore, we sought to evaluate whether a relationship existed between VPA dosage and plasma clearance for both total and unbound or free drug." | 2.68 | Relationship between valproic acid dosage, plasma concentration and clearance in adult monotherapy patients with epilepsy. ( Gidal, BE; Maly, MM; Pitterle, ME; Spencer, NW, 1995) |
| " The median elimination half-life (t1/2) in patients receiving concomitant valproate (VPA) was 43." | 2.68 | Pharmacokinetic interactions between lamotrigine and other antiepileptic drugs in children with intractable epilepsy. ( Boreus, L; Eriksson, AS; Hoppu, K; Nergårdh, A, 1996) |
| "Lamotrigine (LTG) is a new antiepileptic drug (AED), chemically unrelated to the drugs in current use." | 2.68 | Serum concentrations of lamotrigine in epileptic patients: the influence of dose and comedication. ( Jürgens, U; May, TW; Rambeck, B, 1996) |
| "The steady-state pharmacokinetics of valproate (VPA) and topiramate (TPM) were compared during VPA monotherapy, concomitant VPA and TPM therapy, and TPM monotherapy to evaluate pharmacokinetic interactions." | 2.68 | Comparison of the steady-state pharmacokinetics of topiramate and valproate in patients with epilepsy during monotherapy and concomitant therapy. ( Anderson, G; Kramer, LD; Levy, RH; Liao, S; Nayak, RK; Palmer, M; Rosenfeld, WE, 1997) |
| " The mean area under the concentration-time curve, peak concentration and pre-dose concentration of VPA were unchanged by remacemide hydrochloride in three patients on the higher and in 10 patients on the lower dose of remacemide." | 2.68 | Lack of pharmacokinetic interaction between remacemide hydrochloride and sodium valproate in epileptic patients. ( Brodie, MJ; Girvan, J; Jamieson, V; Jones, T; Leach, JP; Richens, A, 1997) |
| "On treatment with carbamazepine (n = 27) and phenytoin (n = 8), the excretion of alpha 1-microglobulin was significantly increased, as compared with the healthy controls." | 2.67 | Renal tubular dysfunction following treatment with anti-epileptic drugs. ( Korinthenberg, R; Wehrle, L; Zimmerhackl, LB, 1994) |
| " Median AUCs of CBZ, VPA and PHT during a dosage interval did not differ significantly after treatment with OXC and placebo." | 2.67 | A double-blind, placebo-controlled interaction study between oxcarbazepine and carbamazepine, sodium valproate and phenytoin in epileptic patients. ( Blacklaw, J; Brodie, MJ; Connelly, D; Forrest, G; Gillham, RA; McKee, PJ; Walker, SM, 1994) |
| " The Cmax and Tmax values of the test formulation were significantly different from the values of the reference in single-(Tmax: 158." | 2.67 | Pharmacokinetic comparison of two valproic acid formulations--a plain and a controlled release enteric-coated tablets. ( Chong, WS; Jang, IJ; Lee, KH; Lee, N; Myung, HJ; Rha, JH; Shin, SG, 1993) |
| " Valproate plasma levels and performances in attention and vigilance tasks were monitored during a 12-h period (daytime), both during monotherapy of conventional valproate (VPA) and 4 weeks after switching to a similar dosage of VPA-CR taken once daily." | 2.67 | Conventional and controlled release valproate in children with epilepsy: a cross-over study comparing plasma levels and cognitive performances. ( Bakker, AM; Brouwer, OF; Edelbroek, PM; Jennekens-Schinkel, A; Lanser, JB; Peters, AC; Pieters, MS; Stijnen, T; van Geel, AA, 1992) |
| " The extent of absorption from sprinkle equaled that from syrup (relative bioavailability = 1." | 2.67 | Comparison of sprinkle versus syrup formulations of valproate for bioavailability, tolerance, and preference. ( Cloyd, JC; Jancik, JT; Jones-Saete, CM; Kriel, RL; Ong, BY; Remmel, RP, 1992) |
| "3." | 2.67 | Differential effects of valproic acid and enzyme-inducing anticonvulsants on nimodipine pharmacokinetics in epileptic patients. ( Baasch, H; Barzaghi, N; Caresia, L; Galimberti, CA; Gatti, G; Manni, R; Mück, W; Parietti, L; Tartara, A; Zucca, C, 1991) |
| " In 2009, a review was published providing guidance for the dosing and therapeutic drug monitoring of antiepileptic drugs during pregnancy." | 2.66 | Therapeutic Drug Monitoring of Antiepileptic Drugs in Women with Epilepsy Before, During, and After Pregnancy. ( Arfman, IJ; Lambrechts, DA; Ter Horst, PGJ; Touw, DJ; Wammes-van der Heijden, EA; Wegner, I, 2020) |
| "This narrative review aimed to provide critical findings of the available literature about the role of pharmacodynamic AEDs' interactions in patients whose epilepsies were treated with polytherapy." | 2.66 | Pharmacodynamic interactions of antiepileptic drugs: From bench to clinical practice. ( Brigo, F; Lattanzi, S; Verrotti, A; Zaccara, G, 2020) |
| "Valproic acid (VPA) is a remarkably safe and effective antiepileptic drug." | 2.66 | The changes of serum zinc, copper, and selenium levels in epileptic patients: a systematic review and meta-analysis. ( Boczek, T; Guo, F; He, Z; Hu, H; Jia, W; Kong, J; Shao, D; Song, Y; Tang, H; Wang, Y; Xia, L; Xu, X; Yang, L; Zhang, X, 2020) |
| "Epilepsy is one of the most common neurological complications in pregnancy; some women continue to use antiepileptic drugs (AEDs) to control seizures." | 2.66 | [Transfer Mechanisms of Compounds between Mother and Fetus/Infant Aimed for Optimized Medication during Pregnancy and Breastfeeding]. ( Furugen, A, 2020) |
| "Valproic acid (VPA) was the first recognized AED to cause disturbances potentially due to metabolic changes and increasing weight." | 2.66 | Reproductive health in patients with epilepsy. ( Chatzistefanidis, D; Georgiou, I; Keramida, A; Kyritsis, AP; Markoula, S; Siarava, E; Zikopoulos, A, 2020) |
| " At a mean daily dosage of less than 20 mg/kg, 83% of the patients became seizure-free." | 2.66 | Monotherapy with valproate in primary generalized epilepsies. ( Beaumanoir, A; Blajev, B; Bourgeois, B; de la Cruz, N; Despland, PA; Egli, M; Geudelin, B; Kaspar, U; Ketz, E; Kronauer, C, 1987) |
| " In the dosage used, l-tryptophan was tolerated well by these children, and seizure frequency, as a whole, remained unaltered." | 2.65 | l-Tryptophan in hyperactive child syndrome associated with epilepsy: a controlled study. ( Ghose, K, 1983) |
| "Phenytoin has been widely prescribed alone; our results indicate that sodium valproate may also be used as a single drug in the treatment of several types of epilepsy." | 2.65 | Comparison of sodium valproate and phenytoin as single drug treatment in epilepsy. ( Johnson, RH; Lambie, DG; Melville, ID; Nanda, RN; Shakir, RA, 1981) |
| " The early knowledge of pediatric patients' CYP2C9-status facilitates the optimization of valproate dosing which contributes to the avoidance of misdosing induced adverse reactions, such as abnormal blood levels of ammonia and alkaline phosphatase, and improves the safety of children's anticonvulsant therapy." | 2.61 | Relevance of CYP2C9 Function in Valproate Therapy. ( Bűdi, T; Csukly, G; Déri, M; Kiss, Á; Monostory, K; Nagy, A; Tóth, K, 2019) |
| "Valproic acid (VPA) is a commonly used antiepileptic drug (AED)." | 2.61 | Valproic acid and Stevens-Johnson syndrome: a systematic review of descriptive studies. ( Kashyap, A; Rashid, M; Undela, K, 2019) |
| "Carbamazepine (CBZ) was found to be effective in most cases." | 2.61 | Epilepsy in patients with EAST syndrome caused by mutation in the KCNJ10. ( Albaradie, R; Alhazmi, R; Alkhaldi, H; Chaudhary, M; Housawi, Y; Mir, A, 2019) |
| "Therefore, in children with a seizure disorder on long-term valproate therapy, 25-OH-Vit D levels should be monitored and appropriate supplementation implemented if levels are deficient." | 2.61 | Valproate decreases vitamin D levels in pediatric patients with epilepsy. ( Chen, F; Guo, H; Hu, Y; Jing, X; Li, G; Lu, XP; Sun, F; Sun, J; Wang, T; Wen, X; Xu, Z, 2019) |
| "Epilepsy is a common neurological condition with a worldwide prevalence of around 1%." | 2.55 | Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. ( Marson, AG; Nevitt, SJ; Sudell, M; Tudur Smith, C; Weston, J, 2017) |
| "Epilepsy is a common neurological condition with a worldwide prevalence of around 1%." | 2.55 | Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. ( Marson, AG; Nevitt, SJ; Sudell, M; Tudur Smith, C; Weston, J, 2017) |
| " If only valproate therapy owns the ability to obtain seizure freedom, then stopping its administration is not suggested, but a low dosage has to be aimed (500-600 mg/day, but not more than 1000 mg/day): according to some studies, most idiopathic generalized epilepsies can be controlled by low valproate dosage." | 2.55 | [Valproate in the treatment of epilepsy and status epilepticus]. ( Bóné, B; Janszky, J; Tényi, D, 2017) |
| "Reflex epileptic seizures can often be prevented by avoidance or modification of triggers or by prophylactic benzodiazepine administration." | 2.53 | Reflex epileptic mechanisms in ictogenesis and therapeutic consequences. ( Guaranha, M; Lin, K; Wolf, P, 2016) |
| "Individually, childhood epilepsy and migraine are two of the most common conditions seen in pediatric neurology." | 2.50 | Migraine and epilepsy in the pediatric population. ( Kossoff, EH; Oakley, CB, 2014) |
| "For patients with migraine, the pregnancy labeling of VPA will be changed from Category "D" to "X." | 2.50 | Risks of neurobehavioral teratogenicity associated with prenatal exposure to valproate monotherapy: a systematic review with regulatory repercussions. ( Gentile, S, 2014) |
| "Full seizure control in the pre-pregnancy year, and adjusting antiepileptic drug doses to maintain plasma drug concentrations throughout pregnancy at values associated with seizure control before pregnancy, have major influences in preserving seizure control during pregnancy." | 2.50 | Treating epilepsy in pregnant women. ( Eadie, MJ, 2014) |
| "Epilepsy is one of the commonest chronic neurological disorders in developing countries." | 2.50 | [Epilepsy, antiepileptic drugs and disorders of reproductive functions of women]. ( Gregoraszczuk, EL; Grzyb, E; Kwiecińska, P, 2014) |
| "Seizures and intracranial hemorrhage are possible medical diseases that any obstetrician may encounter." | 2.49 | Seizures and intracranial hemorrhage. ( Alexander, JM; Wilson, KL, 2013) |
| "Drug-resistant epilepsy has remained a problem since the inception of antiepileptic drug development, despite the large variety of antiepileptic drugs available today." | 2.49 | The search for better epilepsy treatments: from slime mould to coconuts. ( Walker, MC; Williams, RS, 2013) |
| " Consequences of these pharmacokinetic (PK) properties may include adverse events (AEs) and breakthrough seizures, potentially leading to poor adherence." | 2.49 | Extended-release antiepileptic drugs: a comparison of pharmacokinetic parameters relative to original immediate-release formulations. ( Hovinga, CA; Leppik, IE, 2013) |
| " They responded well to the reduction in dosage or to withdrawal of the apparent causing agent." | 2.49 | [Medication-related oculogyric crises: a description of four cases and a review of the literature]. ( Campistol, J; Darling, A; Perez-Duenas, B; Poo, P, 2013) |
| "We report a case of Takotsubo syndrome after epilepsy, and review the literature." | 2.48 | Takotsubo syndrome (TKS): a possible mechanism of sudden unexplained death in epilepsy (SUDEP). ( Dubuisson, N; Dupuis, F; Dupuis, M; Evrard, F; van Rijckevorsel, K; Van Robays, P, 2012) |
| "Acute seizure and status epilepticus constitute one of the major medical emergencies in children." | 2.48 | Management of acute seizure and status epilepticus in pediatric emergency. ( Sasidaran, K; Singhi, P; Singhi, S, 2012) |
| "54; strength of evidence: low) or adverse events (RR 0." | 2.48 | Efficacy and safety of innovator versus generic drugs in patients with epilepsy: a systematic review. ( Ashaye, A; Baker, EL; Baker, WL; Coleman, CI; Kluger, J; Phung, OP; Scholle, JM; Talati, R; White, CM, 2012) |
| "Phenobarbital was associated with a higher rate of drug withdrawal although there was no evidence to suggest that phenobarbital caused more adverse events compared to carbamazepine, valproic acid or phenytoin." | 2.47 | Side effects of phenobarbital in epilepsy: a systematic review. ( Li, YP; Zeng, LN; Zhang, LL, 2011) |
| "Pediatric epilepsy is a common, chronic, and challenging physical illness for children and their families." | 2.46 | Psychiatric concerns in pediatric epilepsy. ( Bujoreanu, IS; DeMaso, DR; Ibeziako, P, 2010) |
| "Studies on mechanisms of seizure generation and propagation have identified new potential targets for AEDs." | 2.45 | New antiepileptic drugs: molecular targets. ( Mula, M, 2009) |
| "Women with untreated epilepsy are more likely to have irregular menstrual cycles than are nonepileptic controls, indicating that the disease itself plays a role in the etiology of these reproductive abnormalities." | 2.44 | Menstrual cycle dysfunction associated with neurologic and psychiatric disorders: their treatment in adolescents. ( Hayes, FJ; Joffe, H, 2008) |
| " Measuring antiepileptic drug levels in body fluids (therapeutic drug monitoring) is frequently used to optimise drug dosage for individual patients." | 2.44 | Therapeutic monitoring of antiepileptic drugs for epilepsy. ( Dahl, ML; Kimland, E; Tomson, T, 2007) |
| "A rationale for their use in migraine prophylaxis is the hypothesis that migraine and epilepsy share several common pathogenetic mechanisms." | 2.44 | Antiepileptic drugs in migraine: from clinical aspects to cellular mechanisms. ( Calabresi, P; Cupini, LM; Galletti, F; Rossi, C; Sarchielli, P, 2007) |
| "Angelman syndrome is a neurogenetic disorder caused by lack of UBE3A gene expression from the maternally inherited chromosome 15 due to various 15q11-q13 abnormalities." | 2.44 | Epilepsy in Angelman syndrome. ( Boyd, SG; Cheron, G; Dan, B; Pelc, K, 2008) |
| "Phenytoin has been causally implicated in three human cancers: lymphoma, myeloma and neuroblastoma, the latter specifically in the setting of foetal hydantoin syndrome." | 2.43 | Cancer risk in people with epilepsy: the role of antiepileptic drugs. ( Driever, PH; Sander, JW; Singh, G, 2005) |
| "We report a 66-year-old man with hepatic encephalopathy due to a non-cirrhotic porto-systemic shunt during the course of treatment for epilepsy with sodium valproate." | 2.43 | [Successful balloon-occluded retrograde transvenous obliteration (B-RTO) in a case of symptomatic epilepsy with hepatic encephalopathy due to non-cirrhotic porto-systemic shunt]. ( Hayashi, S; Noguchi, M; Shibata, A, 2005) |
| "Successful long-term treatment of patients with epilepsy requires selection of an appropriate antiepileptic regimen, optimal dosing and patient compliance." | 2.43 | Progress in pharmaceutical development presentation with improved pharmacokinetics: a new formulation for valproate. ( Genton, P, 2005) |
| "When treatment with valproic acid is the most appropriate treatment to achieve optimal seizure control, a number of measures can be implemented to minimise risk to the fetus." | 2.43 | Valproic acid in epilepsy : pregnancy-related issues. ( Genton, P; Semah, F; Trinka, E, 2006) |
| " Oral forms are almost completely bioavailable but the rate of absorption varies between formulations." | 2.43 | Valproate as a mainstay of therapy for pediatric epilepsy. ( Guerrini, R, 2006) |
| "Epilepsy is a common medical problem and many studies have demonstrated that infants of women with epilepsy (WWE) have a two to threefold higher risk of congenital malformations compared with the background population." | 2.43 | Recent advances on neural tube defects with special reference to Valproic Acid. ( Chiarelli, F; Latini, G; Pelliccia, P; Tana, M; Verrotti, A, 2006) |
| "Agents introduced for the treatment of epilepsy have also been usedsimultaneously for psychiatric indications." | 2.43 | [Anticonvulsants treatment of psychiatric disorder in elderly patients]. ( Bidzan, L, 2006) |
| "Epilepsy was controlled with valproate at the age of 6 years." | 2.42 | A study of EEG and epilepsy profile in Wolf-Hirschhorn syndrome and considerations regarding its correlation with other chromosomal disorders. ( Fiore, LA; Freitas, A; Kim, CA; Valente, KD, 2003) |
| " If a dosage of AEDs in pregnant women with epilepsy is reduced to a reasonable minimum and the monotherapy is preferred, the risk of congenital malformations in their offspring can be minimized." | 2.42 | [Effect of anti-epileptic drugs on human placenta and the fetus]. ( Semczuk, M; Semczuk-Sikora, A, 2004) |
| " Valproate is available in different dosage forms for parenteral and oral use." | 2.41 | Pharmacological and therapeutic properties of valproate: a summary after 35 years of clinical experience. ( Perucca, E, 2002) |
| " The concepts of bioavailability and bioequivalence require further consideration." | 2.41 | Is generic prescribing acceptable in epilepsy? ( Besag, FM, 2000) |
| " However, on rare occasions, they can progress to more severe cutaneous disorders, including Stevens-Johnson syndrome and toxic epidermal necrolysis." | 2.41 | Therapeutic safety monitoring: what to look for and when to look for it. ( Harden, CL, 2000) |
| "Epilepsy affects 1." | 2.41 | New antiepileptic drugs and preparations. ( Jagoda, A; Yoon, Y, 2000) |
| "Neural tube defects were seen in 3% of the sample." | 2.41 | Valproic acid embryopathy: report of two siblings with further expansion of the phenotypic abnormalities and a review of the literature. ( Kozma, C, 2001) |
| "Minimal requirements: seizure-prevention outcome given as fraction of cases; AED or control assigned by random or quasi-random mechanism." | 2.41 | Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials. ( Temkin, NR, 2001) |
| " Rates of metabolism in children may be much faster than in nonelderly adults, requiring dosing adjustments to ensure enough medication is used to control seizures." | 2.41 | Treatment of epilepsy in 3 specialized populations. ( Leppik, IE, 2001) |
| "Fosphenytoin has recently been approved as a substitute for parenteral phenytoin." | 2.40 | New drug therapy for acute seizure management. ( Morton, LD; Pellock, JM; Rizkallah, E, 1997) |
| "Felbamate, however, has been linked with substantially increased incidence of aplastic anemia, and the other new AEDs have been studied for relatively short periods of time." | 2.40 | Pharmacologic and dietary therapies in epilepsy: conventional treatments and recent advances. ( Chapman, DP; Giles, WH, 1997) |
| "Lamotrigine is a phenyltriazine derivative with anticonvulsant properties that initially was tested in adults with partial seizures." | 2.40 | Adult experience with lamotrigine. ( Messenheimer, JA; Willmore, LJ, 1997) |
| " Because dosing is often modest, cost should rarely be the overriding factor in choosing a drug for a patient with newly diagnosed epilepsy in the developed world." | 2.40 | Monostars: an aid to choosing an antiepileptic drug as monotherapy. ( Brodie, MJ, 1999) |
| "Valproic acid is a branched-chained fatty acid, structurally unrelated to any other antiepileptic drug." | 2.39 | Valproic acid. A reappraisal of its pharmacological properties and clinical efficacy in epilepsy. ( Davis, R; McTavish, D; Peters, DH, 1994) |
| "Once epilepsy is diagnosed, long-term treatment with AEDs is recommended, beginning with monotherapy." | 2.39 | Standard approach to antiepileptic drug treatment in the United States. ( Pellock, JM, 1994) |
| " Particular attention has been paid to the role of age in determining the variability of pharmacokinetic parameters, but the effect of other factors, such as different formulations and routes of administration, concomitant treatments, gender and pathological conditions other than epilepsy, have also been considered." | 2.39 | Clinical pharmacokinetics of antiepileptic drugs in paediatric patients. Part I: Phenobarbital, primidone, valproic acid, ethosuximide and mesuximide. ( Avanzini, G; Battino, D; Estienne, M, 1995) |
| "Carnitine treatment does not always prevent the emergence of serious hepatotoxicity, but it does alleviate valproate-induced hyperammonemia." | 2.39 | Carnitine deficiency in epilepsy: Risk factors and treatment. ( Coulter, DL, 1995) |
| " TPM was added to the baseline antiepileptic drug (AED) at a dosage of up to 800 mg/day, after which the baseline drug was discontinued, when possible." | 2.39 | Drug interaction profile of topiramate. ( Bourgeois, BF, 1996) |
| " The usual phenytoin (PHT) dosage in adults is 4-6 mg/kg per day, but children may need a dosage three to five times higher." | 2.38 | Metabolism of antiepileptic medication: newborn to elderly. ( Leppik, IE, 1992) |
| "Epilepsy is a chronic disease that requires long term therapy, and most of the established antiepileptic drugs (the exception is phenobarbital) must be administered several times daily." | 2.38 | Pharmacokinetic evaluation of sustained release formulations of antiepileptic drugs. Clinical implications. ( Bialer, M, 1992) |
| "Rare, serious adverse effects of antiepileptic drugs (AEDs) include hepatotoxicity and bone marrow suppression." | 2.38 | Routine laboratory monitoring for serious adverse effects of antiepileptic medications: the controversy. ( Wyllie, E; Wyllie, R, 1991) |
| "Carnitine is an important nutrient that is present in the diet (particularly in meat and dairy products) and is synthesized from dietary amino acids." | 2.38 | Carnitine, valproate, and toxicity. ( Coulter, DL, 1991) |
| " Increasing the dosage raises the peak serum level and also increases the duration of time during which a minimum effective serum concentration is obtained." | 2.38 | The scope and use of valproate in epilepsy. ( Dean, JC; Penry, JK, 1989) |
| "Starting from Valproat dosage recommendations and serum levels and patient risk from acute hepatic failure, the results of our therapeutic service are set forth." | 2.38 | [Valproate dosage]. ( Meyer, FP; Walther, H, 1989) |
| "Valproic acid has probable teratogenic potential in humans but the number of reported cases is few and the spectrum of anomalies is broad so it is not possible to delineate a definite fetal valproate syndrome." | 2.37 | Congenital malformations associated with maternal use of valproic acid. ( Gauthier, M; Huot, C; Larbrisseau, A; Lebel, M, 1987) |
| "Among psychiatric disorders the acute symptoms of schizophrenia are exacerbated by enhanced GABA-ergic function." | 2.36 | Pharmacology of GABA. ( Meldrum, B, 1982) |
| " New antiepileptic drugs have improved medical management, and technical and theoretical advances in pharmacokinetics have permitted physicians to design balanced dosing for individual patients." | 2.36 | Recent developments in the diagnosis and therapy of epilepsy. ( Crandall, PH; Engel, J; Sterman, MB; Troupin, AS; Wasterlain, CG, 1982) |
| "Valproic acid is a new antiepileptic drug." | 2.36 | Valproic acid. Review of a new antiepileptic drug. ( Bruni, J; Wilder, BJ, 1979) |
| "Valproic acid has become a regular component of antiepileptic therapy." | 2.36 | [Valproic acid in the treatment of epilepsy with special emphasis on serum level determination (author's transl)]. ( Fröscher, W; Gugler, R; Schulz, HU, 1978) |
| " Using this fact we aimed to develop an MHD population pharmacokinetic (PPK) model in Chinese adult epileptic patients to facilitate the clinical implementation of model-guided individualised drug therapy." | 1.91 | Population pharmacokinetics of oxcarbazepine 10-monohydroxy derivative in Chinese adult epileptic patients. ( Dai, H; Hu, Y; Li, X; Yang, Q; Zhang, X, 2023) |
| "Forty patients (39." | 1.91 | Epilepsy and pregnancy. Factors associated with epileptic seizures during pregnancy. ( Barambio, S; Becerra, JL; Chíes, E; Ciurans, J; Codina, M; Fumanal, A; García-Esperón, C; Grau-López, L; Jiménez, M, 2023) |
| "PTZ gradually provoked seizure-related behaviors." | 1.91 | The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure. ( Abnous, K; Gorji Valokola, M; Heydari, FS; Mehri, S; Roohbakhsh, A, 2023) |
| "Nocturnal epilepsy is a neurological disease that has a significant effect on sleep." | 1.91 | Effect of valproate on sleep patterns disturbed by epilepsy. ( Ayala-Guerrero, F; Castro-Domínguez, D; Gutiérrez-Chávez, CA; Mateos-Salgado, EL; Mexicano-Medina, G, 2023) |
| "Epilepsy is characterized by the manifestation of spontaneous and recurrent seizures." | 1.91 | The Effect of Adenosine Signaling on Memory Impairment Induced by Pentylenetetrazole in Zebrafish. ( Bertoncello, KT; Bonan, CD, 2023) |
| "This study was undertaken to determine the impact of dosage in new users of lamotrigine (LTG) and the concomitant intake of valproic acid (VPA) on epidermal necrolysis (EN)." | 1.91 | Effects of dosage in new users of lamotrigine inducing epidermal necrolysis: Results of the German Registry of Severe Skin Reactions. ( Diederich, S; Hemmeter, U; Mockenhaupt, M; Paulmann, M, 2023) |
| "Familial adult myoclonus epilepsy (FAME) is a genetic condition characterized by the occurrence of cortical tremor, myoclonus, and epilepsy." | 1.91 | Current treatment options for familial adult myoclonus epilepsy. ( Bilo, L; Carreno, M; Coppola, A; Cuccurullo, C; Dubbioso, R; Hirsch, E; Licchetta, L, 2023) |
| "Epilepsy is a common chronic neurological disorder in the pediatric population and its evolution can be fatal." | 1.91 | Survey on the management of childhood epilepsy among general practitioners in the area of Marrakech. ( Bourrous, M; Gyamfi, SO; Lahmini, W, 2023) |
| "We present two cases of arginase deficiency with genetically confirmed ARG1 mutation in one and biochemical confirmation in both." | 1.91 | Arginase deficiency-An unheralded cause of developmental epileptic encephalopathy. ( Banerjee, M; Fasaludeen, A; Jose, M; Menon, RN; Pavuluri, H; Radhakrishnan, A; Sundaram, S, 2023) |
| "Studies have reported a recurrence rate ranging from 21%-50%, but most have included patients with different etiologies, electroencephalography (EEG) findings, and seizure types." | 1.91 | Risk of recurrence in patients with an unprovoked tonic-clonic seizure and generalized epileptiform discharges on EEG. ( Beaini, S; Beydoun, A; Hmeimess, G; Hotait, M; Jomaa, N; Nasreddine, W; Wazne, J, 2023) |
| " Therefore, knowledge about the typical adverse events (AEs) for ASMs and other coadministered drugs (CDs) is essential for practitioners and patients." | 1.91 | Adverse Event Profiles of Antiseizure Medications and the Impact of Coadministration on Drug Tolerability in Adults with Epilepsy. ( Knake, S; Kovac, S; Rosenow, F; Strzelczyk, A; van der Goten, M; von Podewils, F; Willems, LM; Zöllner, JP, 2023) |
| "Comorbid diagnosis of headache predicted use of topiramate and VPA, bipolar disease predicted use of LMT and VPA, pain predicted gabapentin, and schizophrenia was associated with VPAs use." | 1.91 | Prescribing Trends of Antiseizure Drugs in Women Veterans With Epilepsy. ( Amuan, ME; Henion, A; Lopez, MR; Panahi, S; Pugh, MJ; VanCott, AC, 2023) |
| "Period of pregnancy was calculated based on birth information in claims data." | 1.91 | Prescribing of valproate and oral antiepileptics for women of childbearing age and during pregnancy in Germany between 2010 and 2020. ( Köster, I; Meyer, I; Scholz, K; Schubert, I; Selke, GW, 2023) |
| " We should collaborate with obstetricians and other professionals to help ensure a safe environment for pregnancy and childbirth." | 1.91 | [Safe and Effective Management of Epilepsy in Pregnancy]. ( Iwasaki, M; Kimura, Y, 2023) |
| "The seizures were refractory to most anti-epileptic drugs but showed some response to Valproic acid." | 1.91 | Potassium Channel Subfamily T Member 1(KCNT1) Pathological Variant Causing Epilepsy Of Infancy With Migrating Focal Seizures: A Case Report. ( Angez, M; Chand, P; Hameed, AN; Kirmani, S, 2023) |
| "97%), switching to or adjusting carbamazepine dosage (27." | 1.91 | The impact of a newly established specialized pediatric epilepsy center in Tanzania: An observational study. ( Aricò, M; Di Noia, SP; Kalolo, A; Mabusi, MS; Mastrangelo, M; Pisani, F, 2023) |
| "This is a type of VPA-related encephalopathy, different from dose-dependent toxic encephalopathy, hyperammonaemic encephalopathy or encephalopathy related to liver failure." | 1.91 | Cerebral and cerebellar pseudoatrophy associated with valproic acid. Report of three pediatric cases. ( Arias-Vivas, E; Duat-Rodríguez, A; García-Peñas, JJ; González-Alguacil, E; Gutiérrez-Delicado, E; Heppe-Montero, M; Justel-Rodríguez, M; Ordoño-Saiz, MV; Púa-Torrejón, RC; Ruiz-Falcó-Rojas, ML; Soto-Insuga, V, 2023) |
| "Epilepsy is characterized by repeated seizure activity." | 1.91 | Impact of ( Kesavan, R; Kumar, RR; Narayan, SK; Ramakrishnan, K; Shewade, D; Venkatraman, S, 2023) |
| "Stroke is the leading cause of epilepsy in the elderly, ahead of degenerative diseases, tumors and head injuries." | 1.91 | Post-stroke seizures: risk factors and management after ischemic stroke. ( Derbali, H; Mansour, M; Messelmani, M; Mrissa, N; Mrissa, R; Ouerdiene, A; Zaouali, J, 2023) |
| "We examined 60 patients with genetic generalized epilepsy (GGE) aged 8-17 years." | 1.72 | Evaluation of optical coherence tomography findings in adolescents with genetic generalized epilepsy. ( Kaplan, AT; Oskan Yalcın, S; Sager, SG, 2022) |
| " We investigated potential transgenerational adverse effects of valproate." | 1.72 | Transgenerational adverse effects of valproate? A patient report from 90 affected families. ( Bewley, S; Braillon, A; Hill, C; MacLennan, AH; Martin, M, 2022) |
| "Epilepsy is a chronic neurological disease that affects more than 50 million people worldwide." | 1.72 | Effects of Low- and High-Dose Valproic Acid and Lamotrigine on the Heart in Female Rats. ( Ateş, B; Çolakoğlu, N; Parlakpınar, H; Vardı, N; Yıldız, A, 2022) |
| "Gabapentin was the most common second- and third-line ASM." | 1.72 | Antiseizure medication treatment pathways for US Medicare beneficiaries with newly treated epilepsy. ( Burke, JF; Choi, H; Terman, SW; Youngerman, BE, 2022) |
| "Valproate (VPA) is an effective treatment for epilepsy and also used in bipolar disorder." | 1.72 | National compliance with UK wide guidelines for usage of valproate in women of childbearing potential. ( Eriksson, SH; Sisodiya, SM; Tittensor, P, 2022) |
| "Epilepsy is a chronic neurological disorder that is characterized by episodes of seizure." | 1.72 | Clinical Evaluation of Levetiracetam in the Treatment of Epilepsy. ( Guan, S; Liu, J; Qian, F; Wang, Y; Wu, H; Yang, J, 2022) |
| "Specific antiseizure medications (ASM) would improve the outcome in post-stroke epilepsy (PSE)." | 1.72 | Efficacy and safety of antiseizure medication in post-stroke epilepsy. ( Groppa, S; Klimpe, S; Sandner, K; Stuckrad-Barre, SV; Uphaus, T; Winter, Y, 2022) |
| "The most common cause of seizures is epilepsy." | 1.72 | [Prospects for the development of new prolonged forms of valproic acid derivatives for the relief of convulsive syndrome]. ( Bespalov, AY; Krasnov, KA; Melekhova, AS; Reinuk, VL; Zorina, VN, 2022) |
| "After several years without seizures, 24 out of 30 had a relapse, which was quickly stopped in 23 out of 30 patients." | 1.72 | [Epilepsy in Angelman syndrome]. ( Bobylova, MY; Glukhova, LY; Kuzmich, GV; Mukhin, KY; Pylayeva, OA, 2022) |
| "Results: Mild cognitive impairment - MCI was diagnosed in 4 patients (28." | 1.72 | HYPERAMMONAEMIA AND COGNITIVE IMPAIRMENT IN EPILEPSY PATIENTS TREATED WITH VALPROIC ACID - PRELIMINARY STUDY. ( Dutkiewicz, J; Pilut, D; Szczygieł-Pilut, EE; Zajączkowska-Dutkiewicz, A, 2022) |
| "People with epilepsy are at a higher risk of developing vascular disease." | 1.72 | Identification of factors associated with new-onset vascular disease in patients admitted for video-EEG monitoring: A longitudinal cohort study. ( Chen, Z; Kwan, P; Nicolo, JP; Nightscales, R; O'Brien, TJ, 2022) |
| "Planned pregnancy was the only independent factor significantly associated with decreased risk of adverse pregnancy outcomes (OR, 0." | 1.72 | Effects of antiepileptic drugs polytherapy on pregnancy outcomes in women with epilepsy: An observation study in northwest China. ( Jiang, W; Jiang, Y; Ma, L; Shi, X; Song, C; Wang, Y; Xia, L; Zhang, Y; Zhao, J, 2022) |
| "The switch between nonseizure and seizure states involves profound alterations in network excitability and synchrony." | 1.72 | Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks. ( D'gama, PP; Hoffshagen, HH; Hotz, AL; Jamali, A; Jurisch-Yaksi, N; Mutlu, AK; Myren-Svelstad, S; Neuhauss, SCF; Ophus, SS; Ostenrath, AM; Yaksi, E, 2022) |
| "While the proband attained seizure control with sodium valproate, his mother's seizures were not well controlled." | 1.72 | A heterozygous missense variant in the YWHAG gene causing developmental and epileptic encephalopathy 56 in a Chinese family. ( Feng, X; Li, F; Pan, H; Song, Z; Xue, J; Yang, C; Yi, Z; Zhang, Y, 2022) |
| "Valproic acid (VPA) is a broad spectrum anticonvulsant drug, which could be partially metabolised by cytochrome P450 (CYP) 2C9 and 2C19 enzymes." | 1.72 | Impact of CYP2C19 and CYP2C9 gene polymorphisms on sodium valproate plasma concentration in patients with epilepsy. ( Li, X; Liu, L; Mao, P; Song, C; Song, W; Zhang, Y, 2022) |
| "Valproic acid (VPA) is an antiepileptic drug, used for focal and generalized seizure." | 1.72 | The impact of valproic acid treatment on weight gain in pediatric patients with epilepsy. ( Battaglia, D; Blasi, V; DI Ruscio, F; Ferrara, P; Gatto, A, 2022) |
| "Epilepsy is the most common childhood neurological disorder in Nigeria." | 1.62 | Serum folate levels in children on long-term anti-seizure medication in a Nigerian tertiary center-Implications for practice and public health. ( Aronu, AE; Bisi-Onyemaechi, AI; Chikani, UN; Ojinnaka, NC; Uwaezuoke, NA, 2021) |
| "Over two-thirds of women/girls with intellectual disability (ID) may have treatment-resistant epilepsy that could benefit from VPA treatment." | 1.62 | Valproate prescribing practices for women with intellectual disability across Europe. ( Angus-Leppan, H; Banks, R; Courtenay, K; Murphy, E; Perera, B; Reuber, M; Shankar, R; Watkins, L, 2021) |
| "Epilepsy is a common chronic neurological condition characterized by recurrent seizures." | 1.62 | ( Miyata-Nozaka, Y; Omar, H; Raymond, AA; Tan, HJ; Wong, SW; Zain, SM, 2021) |
| "Tremor is a common movement disorder that can be induced by medications, including valproate, which is used for the treatment of epilepsy." | 1.62 | Clinical and Kinematic Features of Valproate-Induced Tremor and Differences with Essential Tremor. ( Angelini, L; Berardelli, A; Bologna, M; Cannavacciuolo, A; Colella, D; De Biase, A; Di Bonaventura, C; Giallonardo, AT; Paparella, G, 2021) |
| "Logistic regression analysis showed that maternal age over 31 years, family histories of fetal malformation, and conception after assisted fertility treatment, and also dosage of valproate, carbamazepine, and topiramate, made statistically significant (P<0." | 1.62 | The contribution of non-drug factors to fetal malformation in anti-seizure-medication-treated pregnancy. ( Eadie, MJ; Graham, JE; Hitchcock, AA; Lander, CM; O'Brien, TJ; Vajda, FJE, 2021) |
| "Carbamazepine was the second most common drug followed by lamotrigine and valproic acid." | 1.62 | Post-stroke epilepsy and antiepileptic drug use in men and women. ( Linnér, L; Loikas, D; Sundström, A; von Euler, M; Wettermark, B, 2021) |
| "Clinical outcome was seizure control during the 6 months observation period." | 1.62 | Association of UGT1A6 gene polymorphism with clinical outcome in pediatric epileptic patients on sodium valproate monotherapy. ( Adiga, S; Adiga, U; Banawalikar, N; Kumari, S; Sharmila, KP; Shenoy, V; Shetty, P; Shetty, S, 2021) |
| "Epilepsy is one of the most frequent neurological disorders characterized by an enduring predisposition to generate epileptic seizures." | 1.62 | Histopathological and Biochemical Assessment of Neuroprotective Effects of Sodium Valproate and Lutein on the Pilocarpine Albino Rat Model of Epilepsy. ( Al-Rafiah, AR; Mehdar, KM, 2021) |
| "Furthermore, Aβ42, implicated in Alzheimer's disease, undergoes β-sheet to α-helix transition in presence of PIMT." | 1.56 | The role of isoaspartate in fibrillation and its prevention by Protein-L-isoaspartyl methyltransferase. ( Chakrabarti, P; Chatterjee, BK; Chatterjee, T; Das, G; Dhar, J; Ghosh, S, 2020) |
| "Nodding syndrome is a highly debilitating, generalized seizure disorder, affecting children in subregions of sub-Saharan Africa." | 1.56 | Dried Blood Microsampling-Based Therapeutic Drug Monitoring of Antiepileptic Drugs in Children With Nodding Syndrome and Epilepsy in Uganda and the Democratic Republic of the Congo. ( Colebunders, R; Delahaye, L; Hotterbeekx, A; Idro, R; Mandro, M; Ogwang, R; Stove, CP; Velghe, S, 2020) |
| "Even though Epilepsy is a significant clinical issue in ATP1A3 patients, only a minority of publications provide any information about patients' anti-epileptic treatment." | 1.56 | ATP1A3-related epilepsy: Report of seven cases and literature-based analysis of treatment response. ( Abicht, A; Biskup, S; Boonsimma, P; Borggraefe, I; Gasser, M; Ittiwut, C; Krenn, M; Kuersten, M; Milenkovic, I; Netbaramee, W; Roser, T; Shotelersuk, V; Srichomthomg, C; Suphapeetiporn, K; Tacke, M; von Stülpnagel, C; Wagner, M; Wechapinan, T; Zimprich, F, 2020) |
| "Five groups of each of 12 female rats were orally dosed daily for 8 weeks with either carbamazepine (CBZ) (60 mg/kg), eslicarbazepine (ESL) (80 mg/kg), valproic acid (VPA) (300 mg/kg), levetiracetam (LEV) (50 mg/kg) or saline (control (CTL))." | 1.56 | Effects of carbamazepine, eslicarbazepine, valproic acid and levetiracetam on bone microarchitecture in rats. ( Andersen, NB; Diemar, SS; Ding, M; Eiken, P; Ellegaard, M; Jørgensen, NR; Sejling, AS, 2020) |
| "Carbamazepine was ineffective, and seizures were exacerbated with levetiracetam (LEV)." | 1.56 | Improvement of epilepsy with lacosamide in a patient with ring chromosome 20 syndrome. ( Goji, A; Kagami, S; Mori, T; Tayama, T; Toda, Y, 2020) |
| "Valproic acid (VPA) was a classic antiepileptic drug for fifty years." | 1.56 | Influence of age and co-medication on the concentration and efficacy of valproic acid in Chinese epilepsy children. ( Hu, W; Li, Z; Wang, Y, 2020) |
| "Prepregnancy reduction in VPA dosage reduced the hazard of fetal malformations, whereas ceasing intake of the drug decreased the hazard to one similar to that which applies in the general population, but at a cost of decreased control of epileptic seizures during the pregnancies studied." | 1.56 | Pregnancy after valproate withdrawal-Fetal malformations and seizure control. ( Eadie, MJ; Graham, JE; Hitchcock, AA; Lander, CM; O'Brien, TJ; Vajda, FJE, 2020) |
| "Valproic acid (VPA) is a widely used antiepileptic drugs." | 1.56 | Autophagy associated with the efficacy of valproic acid in PTZ-induced epileptic rats. ( Hu, L; Li, Q; Li, X; Li, Y; Li, Z; Lu, J; Tao, J; Wang, G; Wang, Y, 2020) |
| " Both, the type I isobolographic analysis and the test of parallelism of dose-response effects of the ASDs were used so as to properly classify interaction among three ASDs, administered in a fixed ratio combination of 1:1:1." | 1.56 | Sub-additive (antagonistic) interaction of lacosamide with lamotrigine and valproate in the maximal electroshock-induced seizure model in mice: an isobolographic analysis. ( Bojar, H; Florek-Łuszczki, M; Karwan, S; Kondrat-Wróbel, M; Plewa, Z; Zagaja, M; Łuszczki, JJ, 2020) |
| " The aim was to use long-term TDM to investigate pharmacokinetic variability of ASMs in these patients." | 1.56 | Pharmacokinetic Variability During Long-Term Therapeutic Drug Monitoring of Valproate, Clobazam, and Levetiracetam in Patients With Dravet Syndrome. ( Bjørnvold, M; Burns, ML; Heger, K; Johannessen Landmark, C; Johannessen, SI; Lund, C; Sætre, E, 2020) |
| " This study investigated the effect of delayed or missed doses on the pharmacokinetics (PK) of valproic acid (VPA) in patients with epilepsy and established remedial dosing recommendations for nonadherent patients." | 1.56 | Remedial dosing recommendations for delayed or missed doses of valproic acid in patients with epilepsy based on Monte Carlo simulations. ( Ding, JJ; Jiao, Z; Wang, CY; Yu, EQ; Zhu, GX, 2020) |
| "Epilepsy is very difficult to treat and often involves the combination of two or more AEDs." | 1.56 | Antiepileptic combination therapy with Stevens-Johnson syndrome and toxic epidermal necrolysis: Analysis of a Japanese pharmacovigilance database. ( Hayashi, T; Noguchi, Y; Tachi, T; Takaoka, M; Teramachi, H, 2020) |
| "Metabolic syndrome was more frequent in patients with epilepsy compared with healthy participants (32." | 1.56 | Metabolic syndrome and obstructive sleep apnea syndrome among patients with epilepsy on monotherapy. ( Ataklı, D; Balçık, ZE; Baslo, SA; Öztürk, O; Söylemez, E, 2020) |
| " However, the free form of VPA is responsible for its pharmacologic and toxic effects, and the total and free concentrations are highly discordant because of VPA's highly protein bound and saturable binding characteristics." | 1.56 | Safety range of free valproic acid serum concentration in adult patients. ( Huang, SY; Kuo, CH; Tseng, YJ; Wang, CY; Wang, KC; Wu, CC, 2020) |
| "Levetiracetam has replaced sodium valproate as the most frequently prescribed ASM in pediatric patients." | 1.56 | Trends of anti-seizure medication use in pediatric patients in six cities in China from 2013 to 2018. ( Dai, H; Feng, J; Yu, L; Yu, Z, 2020) |
| "Valproic acid (VPA) is a widely used anti-epileptic drug (AED) of demonstrated efficacy." | 1.56 | Risk-benefit assessment of treatment of epileptic women of childbearing age with valproic acid. ( Baraldés-Rovira, M; Gallego, Y; Mauri-Capdevila, G; Purroy, F; Quílez, A; Sanahuja, J, 2020) |
| " A dose-response relationship was demonstrated and the risk of NDs was more particularly increased for an exposure to VPA during the second or third trimesters of pregnancy." | 1.56 | Risk of early neurodevelopmental disorders associated with in utero exposure to valproate and other antiepileptic drugs: a nationwide cohort study in France. ( Blotiere, PO; Coste, J; Dray-Spira, R; Mikaeloff, Y; Miranda, S; Peyre, H; Ramus, F; Weill, A; Zureik, M, 2020) |
| "To study the risk of intellectual disability and delayed development in childhood milestones among children of women who used valproate or other AEDs during pregnancy." | 1.56 | Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Intellectual Disability and Delayed Childhood Milestones. ( Christensen, J; Daugaard, CA; Dreier, JW; Pedersen, L; Sun, Y, 2020) |
| "Valproic acid was less frequently prescribed to female patients." | 1.56 | Observational multicentre study into the use of antiepileptic drugs in Spanish neurology consultations. ( Campos Blanco, DM; Castro Vilanova, MD; López Gonzalez, FJ; Mercadé Cerdá, JM; Querol Pascual, MR; Serrano Castro, P, 2020) |
| "Epilepsy was present in 29." | 1.51 | [Epilepsy in children with congenital hemiparesis secondary to perinatal ictus]. ( Alonso, X; Campistol, J; Escofet, C; Fons, C; Macaya, A; Revilla Orías, MD, 2019) |
| "Severe hyponatremia was defined as a serum sodium level < 130 mEq/L." | 1.51 | Prevalence and risk factors for hyponatremia in adult epilepsy patients: Large-scale cross-sectional cohort study. ( Imai, K; Inoue, Y; Kagawa, Y; Ohta, A; Takahashi, Y; Yamamoto, Y, 2019) |
| "Epilepsy has a growing frequency, particularly in the elderly." | 1.51 | Cognitive performances in patients affected by late-onset epilepsy with unknown etiology: A 12-month follow-up study. ( Calabresi, P; Cesarini, EN; Costa, C; Di Santo, S; Farotti, L; Franchini, F; Izzi, F; Lanari, A; Liguori, C; Manfredi, N; Mercuri, NB; Parnetti, L; Placidi, F; Romoli, M; Salvadori, N; Spanetta, M, 2019) |
| "The predominant seizure types in NLLOE were focal to bilateral tonic-clonic seizures (30%) as well as focal onset impaired awareness motor seizures (IAMS) (22%) and focal onset impaired awareness nonmotor seizures (IANMS) (22%)." | 1.51 | Nonlesional late-onset epilepsy: Semiology, EEG, cerebrospinal fluid, and seizure outcome characteristics. ( Flöel, A; Hamann, L; Süße, M; von Podewils, F, 2019) |
| "Its use in pregnancy is associated with increased risks of congenital malformations and adverse neurodevelopment in the offspring and may be associated with an increased risk of attention-deficit/hyperactivity disorder (ADHD)." | 1.51 | Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Risk for Attention-Deficit/Hyperactivity Disorder in Offspring. ( Brikell, I; Christensen, J; Dalsgaard, S; Dreier, JW; Pedersen, L; Sun, Y, 2019) |
| "Epileptic seizures are frequent in patients with glioblastoma, and anticonvulsive treatment is often necessary." | 1.51 | AMPA receptor antagonist perampanel affects glioblastoma cell growth and glutamate release in vitro. ( Bergner, C; Hörnschemeyer, J; Kirschstein, T; Köhling, R; Krause, BJ; Lange, F; Linnebacher, M; Mullins, CS; Porath, K; Weßlau, K, 2019) |
| " The total CRST score was significantly associated with epilepsy duration and maximum VPA dosage (B = 0." | 1.51 | The clinical characteristics and related factors of tremor in patients with epilepsy. ( Chen, J; Jiang, X; Lu, L; Xiao, Y; Xiong, W; Zhang, Y; Zhou, D, 2019) |
| " Interestingly, regarding VPA dosage, we found that women taking equal or more than 700 mg/day of VPA have lower scores on empowerment in all dimensions compared with women with a VPA dosage lower than 700 mg/day." | 1.51 | Level of empowerment and decision-making style of women with epilepsy in childbirth age. ( Canevini, MP; Cutica, I; Pravettoni, G; Riva, S; Turner, K; Zambrelli, E, 2019) |
| "Carnitine levels were significantly low in patients under valproic acid therapy, however they were not found to be correlated with MDA, 8-OHdG or LFTs." | 1.51 | Effects of levetiracetam and valproic acid treatment on liver function tests, plasma free carnitine and lipid peroxidation in childhood epilepsies. ( Albayrak, P; Deda, G; Doğan, Ö; Eminoglu, FT; Haznedar, P; Öz Tunçer, G; Teber, S, 2019) |
| "Valproic acid (VPA) is a clinical medicine primarily prescribed to control epileptic symptoms." | 1.51 | Potential biomarker of fibroblast growth factor 21 in valproic acid-treated livers. ( Chen, J; Guo, C; Li, R; Liang, X; Xu, X, 2019) |
| "Focal epilepsy was diagnosed in 244 (69." | 1.51 | Why do some women with epilepsy use valproic acid despite current guidelines? A single-center cohort study. ( Bosak, M; Słowik, A; Turaj, W, 2019) |
| "Epilepsy is a common worldwide neurological disorder." | 1.51 | Self-reported attitudes about medication in Lebanese people with epilepsy. ( Al-Hajje, A; Boumediene, F; Jost, J; Mroueh, L; Preux, PM; Ratsimbazafy, V; Salameh, P, 2019) |
| "The intractable seizures showed complete but transient responsiveness to pyridoxal phosphate and finally controlled by valproate treatment." | 1.51 | ARX-associated infantile epileptic-dyskinetic encephalopathy with responsiveness to valproate for controlling seizures and reduced activity of muscle mitochondrial complex IV. ( Chu, VL; Fung, CW; Kwong, AK; Rodenburg, RJT; Smeitink, J, 2019) |
| "However, seizures are not typical and the majority of them were seizure-free." | 1.51 | A 16q22.2-q23.1 deletion identified in a male infant with West syndrome. ( Goji, A; Imoto, I; Ito, H; Kagami, S; Kohmoto, T; Mori, K; Mori, T; Toda, Y, 2019) |
| "The aims of this study were to develop a population pharmacokinetic (PPK) model of lamotrigine (LTG) in Chinese epileptic children by using nonlinear mixed effects modeling (NONMEM) and to investigate the effects of valproic acid (VPA) and genetic polymorphisms of the major metabolizing enzymes (UGT1A4, UGT2B7) on the pharmacokinetics of LTG." | 1.48 | Population pharmacokinetics of lamotrigine co-administered with valproic acid in Chinese epileptic children using nonlinear mixed effects modeling. ( Chen, Y; Liu, L; Liu, M; Liu, S; Lu, T; Wang, H; Xu, S; Zhao, L; Zhao, M, 2018) |
| "Curcumin is a phytochemical with promising effects on epilepsy treatment." | 1.48 | Micronization potentiates curcumin's anti-seizure effect and brings an important advance in epilepsy treatment. ( Aguiar, GPS; Bertoncello, KT; Oliveira, JV; Siebel, AM, 2018) |
| "Lamotrigine was the most frequently initiated drug in psychiatry, in both boys and girls." | 1.48 | Utilization of Antiepileptic Medicines in Swedish Children and Adolescents with Different Diagnoses. ( Karlsson Lind, L; von Euler, M; Wettermark, B; Wide, K, 2018) |
| "Levetiracetam was the most frequently prescribed AED (62/124, 50%)." | 1.48 | Safety of antiepileptic drugs in children and young people: A prospective cohort study. ( Choonara, I; Egunsola, O; Sammons, HM; Whitehouse, WP, 2018) |
| " The purpose of this study was to characterise pharmacokinetic variability of VPA in pregnancy, and discuss use of therapeutic drug monitoring (TDM) as guidance to exposure in women." | 1.48 | Pharmacokinetic variability of valproate during pregnancy - Implications for the use of therapeutic drug monitoring. ( Baftiu, A; Burns, ML; Farmen, AH; Johannessen Landmark, C; Johannessen, SI; Lossius, MI; Tomson, T, 2018) |
| "Hyperammonemic encephalopathy secondary to the use of valproate is rare without evidence of hepatotoxicity, and it usually presents with confusion, agitation, irritability, cognitive disturbances, lethargy, coma, and death." | 1.48 | Valproate-induced Hyperammonemic Encephalopathy Presenting as Catatonia. ( Espínola-Nadurille, M; Oñate-Cadena, N; Pérez-Esparza, R; Ramírez-Bermúdez, J, 2018) |
| "Carbamazepine was the most chosen antiepileptic drug for secondary prophylaxis, followed by valproate acid, and levetiracetam." | 1.48 | [A nationwide multi-center questionnaire survey on the management and treatment of post-stroke seizure and epilepsy in Japan]. ( Abe, S; Fukuma, K; Higashida, K; Ihara, M; Nagatsuka, K; Okuno, Y; Tanaka, T; Tomari, S; Toyoda, K; Yamagami, H, 2018) |
| "Although some drugs used in the treatment of epilepsy are known to affect body weight, the hormonal factors responsible have not been sufficiently described." | 1.48 | The effects of valproate and topiramate use on serum insulin, leptin, neuropeptide Y and ghrelin levels in epileptic children. ( Alver, A; Cansu, A; Çiçek, NP; Kamaşak, T; Okten, A; Serin, M, 2018) |
| "Evidence for the comparative teratogenic risk of antiepileptic drugs is insufficient, particularly in relation to the dosage used." | 1.48 | Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry. ( Battino, D; Bonizzoni, E; Craig, J; Lindhout, D; Perucca, E; Sabers, A; Thomas, SV; Tomson, T; Vajda, F, 2018) |
| "Individualised epilepsy care is the gold standard, not blanket bans on drug choice based on gender." | 1.48 | Valproate and epilepsy: for women as well as men. ( Lawthom, C, 2018) |
| "Valproic acid (VPA) is a first-line anti-epileptic drug that is used in the treatment of generalized and partial seizures." | 1.48 | Population pharmacokinetics of valproic acid in epileptic children: Effects of clinical and genetic factors. ( Chen, Y; Guo, Y; Wang, Z; Xu, S; Zhao, L; Zhao, M, 2018) |
| " Therefore, this study aimed to establish a population pharmacokinetic (PPK) model of LTG in Chinese children with epilepsy and to comprehensively evaluate the effects of genetic variations in drug-metabolizing enzymes, transporters, and a transcriptional regulator on LTG pharmacokinetics." | 1.48 | A Population Pharmacokinetic-Pharmacogenetic Model of Lamotrigine in Chinese Children With Epilepsy. ( Chen, Y; Lu, T; Wang, H; Wang, Z; Xu, S; Zhao, L; Zhao, M, 2018) |
| " Clinical data on epilepsy, characteristics of VPA treatment, risk factors for VHT, laboratory data on liver and pancreas functions, and adverse effects were collected." | 1.48 | Variants p.Q1236H and p.E1143G in mitochondrial DNA polymerase gamma POLG1 are not associated with increased risk for valproate-induced hepatotoxicity or pancreatic toxicity: A retrospective cohort study of patients with epilepsy. ( Ansakorpi, H; Eriksson, K; Haapala, P; Haataja, L; Hinttala, R; Hynynen, J; Jyrkilä, A; Kälviäinen, R; Kärppä, M; Komulainen-Ebrahim, J; Lähdetie, J; Majamaa, K; Mäkitalo, A; Myllynen, P; Pokka, T; Pylvänen, L; Rantala, H; Sokka, A; Uusimaa, J; Vieira, P; Ylikotila, P, 2018) |
| "Background The impact of adverse events (AEs) of antiepileptic drugs (AEDs) have an impact on compliance and dropouts." | 1.48 | Antiepileptic drugs in migraine and epilepsy: Who is at increased risk of adverse events? ( Bedetti, C; Calabresi, P; Caproni, S; Corbelli, I; Costa, C; Cupini, LM; Eusebi, P; Romoli, M; Sarchielli, P; Siliquini, S, 2018) |
| " While the concentration of 4-ene-VPA was not suitable as an early warning index, the results provide clear theoretical guidance for the rational and safe clinical use of VPA." | 1.46 | Association of CYP2C9, CYP2A6, ACSM2A, and CPT1A gene polymorphisms with adverse effects of valproic acid in Chinese patients with epilepsy. ( Ma, HY; Pan, J; Wang, C; Wang, P; Yang, LP; Yang, X, 2017) |
| "Valproic acid (VPA) is a widely prescribed broad-spectrum antiepileptic drug." | 1.46 | Influence of age and co-medication on the steady-state pharmacokinetics of valproic acid in Tunisian patients with epilepsy. ( Atheymen, R; Ben Mahmoud, L; Ghozzi, H; Hakim, A; Sahnoun, Z; Zeghal, K, 2017) |
| "Valproic acid (VPA) is an effective antiepileptic drug and mood stabilizer." | 1.46 | Monitoring Protein-Unbound Valproic Acid Serum Concentrations in Clinical Practice. ( de Jong, K; de Maat, M; Essink, G; Klok, B; Stalpers-Konijnenburg, S; van Erp, N; van Luin, M; Wallenburg, E, 2017) |
| " The aim of the study was to conduct an in vivo evaluation of the relationship between treatments with synthetic cannabinoid arachidonyl-2'-chloroethylamide (ACEA) alone or in combination with valproic acid (VPA) and hippocampal neurogenesis in a mouse pilocarpine model of epilepsy." | 1.46 | A Long-Term Treatment with Arachidonyl-2'-Chloroethylamide Combined with Valproate Increases Neurogenesis in a Mouse Pilocarpine Model of Epilepsy. ( Andres-Mach, M; Dudra-Jastrzębska, M; Haratym, J; Haratym-Maj, A; Maj, M; Rola, R; Zagaja, M; Łuszczki, JJ, 2017) |
| "Valproic acid data were adequately described by a 1-compartment model." | 1.46 | Population Pharmacokinetics of Valproic Acid in Patients with Mania: Implication for Individualized Dosing Regimens. ( Methaneethorn, J, 2017) |
| "Valproic acid (VPA) has been widely used in Chinese patients after craniotomy." | 1.46 | Analysis of the Variables Influencing Valproic Acid Concentration in the Serum and Cerebrospinal Fluid of Chinese Patients After Craniotomy. ( Chen, W; Gao, W; Li, Z; Liu, G, 2017) |
| " The mean serum concentrations and the mean serum concentrations per weight per daily dose per bioavailability (F) of anti-epileptic drugs (AEDs) before and during the treatment were assessed." | 1.46 | Effect of ketogenic diet and other dietary therapies on anti-epileptic drug concentrations in patients with epilepsy. ( Chang, MJ; Heo, G; Kim, SH, 2017) |
| "New-onset stroke was seen in three cases (10%) of the control group and in two cases (6." | 1.46 | Clinical study on anti-epileptic drug with B vitamins for the treatment of epilepsy after stroke. ( Huang, HL; Wang, N; Xu, L; Yu, CY; Zhou, H, 2017) |
| "The purpose was to investigate pharmacokinetic variability of valproic acid (VPA) in women of childbearing age by therapeutic drug monitoring (TDM) data to elucidate the variable relationship between dose and serum concentrations with the ultimate aim of facilitating safer use of VPA." | 1.46 | Pharmacokinetic variability of valproate in women of childbearing age. ( Baftiu, A; Burns, ML; Farmen, AH; Johannessen Landmark, C; Johannessen, SI; Lossius, MI; Tomson, T, 2017) |
| " Serum levels of valproate were estimated using HPLC for pharmacokinetic study." | 1.46 | Pharmacokinetic and pharmacodynamic interaction of hydroalcoholic extract of Ocimum sanctum with valproate. ( Gupta, YK; Joshi, D; Kaleekal, T; Kumar, R; Sarangi, SC, 2017) |
| "Melatonin is an indolic hormone that regulates a plethora of functions ranging from the regulation of circadian rhythms and antioxidant properties to the induction and maintenance of tumor suppressor pathways." | 1.46 | Melatonin and Hippo Pathway: Is There Existing Cross-Talk? ( Blandino, G; Lo Sardo, F; Muti, P; Strano, S, 2017) |
| "Epilepsy is one of the most common neurological diseases in childhood and adolescence." | 1.46 | Effects of Carbamazepine and Valproate on Serum Aspartate Aminotransferase, Alanine Aminotransferase and Gamma - Glutamyltransferase in Children. ( Hadzagic-Catibusic, F; Hasanbegovic, E; Melunovic, M; Uzicanin, S; Zubcevic, S, 2017) |
| "• Valproic acid has a cumulative effect on inhibiting brain activity in epileptogenic regions." | 1.46 | Resting-state fMRI revealed different brain activities responding to valproic acid and levetiracetam in benign epilepsy with central-temporal spikes. ( Dante, M; Hu, Z; Li, K; Li, Q; Li, Z; Lu, G; Wu, H; Xu, Q; Yang, F; Zhang, Q; Zhang, Z, 2017) |
| "The number of seizure-free patients in the last 4 weeks was overall CBZ/VPA/LTG/LEV=60%/79%/67%/67%, for generalized epilepsy was CBZ/VPA/LTG/LEV=67%/89%/65%/94%, and for localization-related epilepsy was CBZ/VPA/LTG/LEV=59%/71%/67%/57%." | 1.46 | Efficacy and tolerability of anti-epileptic drugs-an internet study. ( Baker, G; Wieshmann, UC, 2017) |
| "Valproic acid (VPA) was the most prescribed single therapy in young patients (<15years), whereas carbamazepine (CBZ) was preferred by clinicians in older patients." | 1.46 | Effectiveness and tolerability of antiepileptic drugs in 104 girls with Rett syndrome. ( Canevini, MP; La Briola, F; Nowbut, MS; Peron, A; Savini, MN; Turner, K; Vignoli, A, 2017) |
| " The UHPLC-MS/MS method demonstrated a good analytical performance essential for therapeutic drug monitoring, which would potentially lead to clinically relevant improvements in VPA dosage and patient management." | 1.46 | Simultaneous Determination of Valproic Acid and Its Major Metabolites by UHPLC-MS/MS in Chinese Patients: Application to Therapeutic Drug Monitoring. ( Li, G; Qiu, F; Sun, Y; Zhang, T; Zhao, L; Zhao, M, 2017) |
| "Sulforaphane (SFN) is a thiol compound found in wide abundance in cruciferous plants that has numerous reported therapeutic efficacies." | 1.46 | Sulforaphane protects against sodium valproate-induced acute liver injury. ( Atef, H; El-Khouly, OA; Nazmy, EA; Said, E, 2017) |
| "Valproic acid (VPA) is a widely used antiepileptic drug (AED)." | 1.46 | Drug interaction between valproic acid and carbapenems in patients with epileptic seizures. ( Chen, NC; Chen, SD; Chuang, YC; Hsiao, SC; Huang, CR; Lin, CH; Lu, YT; Tsai, WC, 2017) |
| "Epilepsy is a kind of neurogenic diseases with high prevalence and characterized by seizure, brain paradoxical discharge and convulsion in spontaneous, transient, recurrent and uncontrolled manner." | 1.43 | [Establish and use of an epilepsy model in larval zebrafish]. ( Song, DQ; Tang, S; Zhang, JP; Zheng, YM, 2016) |
| "A treatment with valproic acid was started, obtaining control of the neurological disease." | 1.43 | Recurrent seizures during acute acquired toxoplasmosis in an immunocompetent traveller returning from Africa. ( Bassetti, M; Beltrame, A; Buonfrate, D; Crichiutti, G; Meroni, V; Venturini, S, 2016) |
| "Epilepsy is an independent prognostic factor for longer survival in glioblastoma patients." | 1.43 | Prognostic relevance of epilepsy at presentation in glioblastoma patients. ( Berendsen, S; Bours, V; Broekman, ML; Kauw, F; Kroonen, J; Poulet, C; Robe, PA; Seute, T; Snijders, TJ; Spliet, WG; Varkila, M; Willems, M, 2016) |
| "Levetiracetam was independently associated with anger/aggression, nervousness/agitation, upset stomach, depression, and sleep disturbance; lamotrigine with nervousness/agitation, upset stomach, and difficulty concentrating; and valproic acid with upset stomach and shaky hands." | 1.43 | Specific adverse effects of antiepileptic drugs--A true-to-life monotherapy study. ( Fidzinski, P; Gaus, V; Holtkamp, M; Kowski, AB; Losch, F; Weissinger, F, 2016) |
| "Although Fanconi syndrome is rare in patients with epilepsy treated with sodium valproate (VPA), the prevalence might be higher in children with severe motor and intellectual disabilities (SMID)." | 1.43 | Outcome of renal proximal tubular dysfunction with Fanconi syndrome caused by sodium valproate. ( Sato, S; Watanabe, T; Yamazaki, S; Yoshikawa, H, 2016) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 1.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| " The correlation with dose may be a spurious finding related to the fact that physicians, in adjusting dosage according to clinical response, are more likely to use larger doses in patients with high clearance values." | 1.43 | An investigation of the influence of patient-related factors and comedications on lamotrigine clearance in patients with epilepsy. ( Alexandre, V; Baldoni, AO; de Santi Ferreira, FI; Freitas-Lima, P; Martinez, EZ; Pereira, LR; Perucca, E; Queiroz, RH; Sakamoto, AC, 2016) |
| " No correlation was found between duration or dosage of VPA and BMDs." | 1.43 | Bone health and vitamin D status in young epilepsy patients on valproate monotherapy. ( Albaghdadi, O; Alhalabi, MS; Alourfi, Z; Youssef, LA, 2016) |
| "Depression was evaluated in all experimental groups using tail suspension and forced swim test on days 1, 5, 10 and 15, 2h after pentylenetetrazole challenge." | 1.43 | Adjuvant indoleamine 2,3-dioxygenase enzyme inhibition for comprehensive management of epilepsy and comorbid depression. ( Goel, RK; Singh, T, 2016) |
| "The risk ratio for seizure increase on hormonal (18." | 1.43 | Differential impact of contraceptive methods on seizures varies by antiepileptic drug category: Findings of the Epilepsy Birth Control Registry. ( Cahill, KE; Fowler, KM; Hauser, WA; Herzog, AG; Mandle, HB, 2016) |
| "Valproic acid (VPA) is a broad-spectrum antiepileptic drug used for a variety of neurologic disorders." | 1.43 | Steady-state pharmacokinetic simulation of intermittent vs. continuous infusion valproic acid therapy in non-critically ill and critically ill patients. ( Cook, AM; Van Matre, ET, 2016) |
| " The dosage of PB was ranked first followed by that of CBZ and finally by the VPA." | 1.43 | [Therapeutic drug monitoring of three antiepileptic drugs - Back on twenty years of experience]. ( Badrane, N; Bencheikh, RS; Moussa, LA; Ouammi, L; Serragui, S; Tanani, DS; Zalagh, F, 2016) |
| "Carbamazepine-treated patients showed mean serum thyroid hormone levels significantly lower than baseline evaluation and the control group." | 1.42 | Evaluation of thyroid hormones in children receiving carbamazepine or valproate: a prospective study. ( Arapoglu, M; Dalgıç, N; Kafadar, İ; Kılıç, BA; Yalçın, K, 2015) |
| "There are several reports describing population pharmacokinetic (PPK) models of valproic acid (VPA)." | 1.42 | Population pharmacokinetics of valproic acid in adult Chinese epileptic patients and its application in an individualized dosage regimen. ( Guo, XZ; Huang, PF; Jiao, Z; Lin, WW; Liu, YW; Ma, CL; Wang, CL; Wang, HY, 2015) |
| " Our data suggest that valproate has adverse effects on renal tubular functions." | 1.42 | Does nephrotoxicity exist in pediatric epileptic patients on valproate or carbamazepine therapy? ( Buyan, N; Demir, E; Gücüyener, K; Gülbahar, Ö; Gürkaş, E; Havali, C; Serdaroğlu, A; Yılmaz, Ü, 2015) |
| "The present study aimed to establish population pharmacokinetic model for phenobarbital (PB), examining and quantifying the magnitude of PB interactions with other antiepileptic drugs concomitantly used and to demonstrate its use for individualization of PB dosing regimen in adult epileptic patients." | 1.42 | Nonlinear mixed effects modelling approach in investigating phenobarbital pharmacokinetic interactions in epileptic patients. ( Golubović, B; Jovanović, M; Kovačević, SV; Martinović, Ž; Miljković, B; Prostran, M; Vučićević, K, 2015) |
| "Valproic acid (VPA) follows a non-linear pharmacokinetic profile in terms of protein-binding saturation." | 1.42 | A population pharmacokinetic model of valproic acid in pediatric patients with epilepsy: a non-linear pharmacokinetic model based on protein-binding saturation. ( Ding, J; Jiao, Z; Li, X; Lin, W; Miao, L; Wang, C; Wang, Y; Zhao, L; Zhao, Z, 2015) |
| "Weight gain and alopecia were the most common patient-reported CSEs in this study, and weight gain was the most likely cosmetic side effect to result in dosage adjustment or medication discontinuation." | 1.42 | Cosmetic side effects of antiepileptic drugs in adults with epilepsy. ( Buchsbaum, R; Chen, B; Choi, H; Detyniecki, K; Hirsch, LJ; Javed, A; Kato, K; Legge, A; Moeller, J, 2015) |
| "Valproic acid treated animals were treated from 5 days preceding behavioral testing in the Morris water maze at a clinically relevant concentration." | 1.42 | Standard dose valproic acid does not cause additional cognitive impact in a rodent model of intractable epilepsy. ( Jellett, AP; Jenks, K; Lucas, M; Scott, RC, 2015) |
| "Valproic acid (VPA) is an antiepileptic drug that has been associated with impaired hemostasis and increased risk for postsurgical bleeding." | 1.42 | Effects of chronic administration of valproic acid to epileptic patients on coagulation tests and primary hemostasis. ( Canevini, MP; Cattaneo, M; Chiesa, V; Fontana, G; Lussana, F; Vignoli, A; Zighetti, ML, 2015) |
| "Secondary enuresis is a common adverse event associated with valproate use in children, which is not usually spontaneously reported and is reversible in most cases." | 1.42 | Valproate-induced enuresis: a prospective study. ( Arabi, M; Beydoun, A; Hmaimess, G; Makke, Y; Nasreddine, W; Sabbagh, S; Yamak, WR, 2015) |
| "Patients with Alzheimer's disease are at increased risk for unprovoked seizures and epilepsy compared with age-matched controls." | 1.42 | Reduction of epileptiform activity by valproic acid in a mouse model of Alzheimer's disease is not long-lasting after treatment discontinuation. ( Hiltunen, M; Pitkänen, A; Tanila, H; Viswanathan, J; Ziyatdinova, S, 2015) |
| " When the results of CYP2C9 genotyping and CYP2C9 expression were combined, the patients' VPA-metabolizing capacity was predicted, and VPA dosing was adjusted to the patients' CYP2C9-status." | 1.42 | Clinical significance of CYP2C9-status guided valproic acid therapy in children. ( Bűdi, T; Garami, M; Háfra, E; Kiss, Á; Monostory, K; Nagy, A; Szever, Z; Tapodi, A; Temesvári, M; Tóth, K, 2015) |
| "Valproic acid was prescribed most frequently as first and second treatment, followed by vigabatrin." | 1.42 | Epilepsy in children with tuberous sclerosis complex: Chance of remission and response to antiepileptic drugs. ( Bindels-de Heus, K; de Wit, MC; Moll, HA; Overwater, IE; Rietman, AB; Ten Hoopen, LW; Vergouwe, Y, 2015) |
| "Epilepsy is common in individuals with autism spectrum disorder (ASD) and intellectual disabilities (ID)." | 1.42 | Impact of epilepsy and antiepileptic medications on the metabolic profile in adults with autism spectrum disorder and intellectual disabilities. ( Katz, N; Moses, L; Weizman, A, 2015) |
| "Despite former publications no clear seizures could be reproduced but it was possible to establish focal EPs, which proved to be a reliable marker for epileptic activity." | 1.42 | Reduction of epileptiform activity through local valproate-implants in a rat neocortical epilepsy model. ( Altenmüller, DM; Feuerstein, TJ; Freiman, TM; Hebel, JM; Herrmann, LS; Rassner, MP; Volz, S, 2015) |
| "Multiple generalized seizures occurred in all homozygous mice around three weeks after birth." | 1.42 | Epileptogenesis and epileptic maturation in phosphorylation site-specific SNAP-25 mutant mice. ( Kataoka, M; Miyaoka, H; Otsuka, S; Saito, M; Suzuki, E; Takahashi, M; Watanabe, S; Yamamori, S, 2015) |
| "Oxcarbazepine was most widely used, followed by valproic acid." | 1.42 | Trends in Antiepileptic Drug Prescriptions for Childhood Epilepsy at a Tertiary Children's Hospital in Korea, 2001-2012. ( Ah, YM; Cho, YS; Jung, AH; Kim, KJ; Lee, JY, 2015) |
| " In this study, we developed a population-based pharmacokinetic (PK)-pharmacodynamic (PD) model to determine the optimal concentration of VPA according to the clinical characteristics of each patient." | 1.42 | Determination of the Optimal Concentration of Valproic Acid in Patients with Epilepsy: A Population Pharmacokinetic-Pharmacodynamic Analysis. ( Ishitsu, T; Matsuda, K; Nakagawa, K; Nakashima, H; Nishimura, M; Ogusu, N; Oniki, K; Ono, T; Saruwatari, J; Shimomasuda, M; Yasui-Furukori, N, 2015) |
| " Maternal levels and dosing information were used for estimating the maternal apparent oral clearance and the paired umbilical cord and maternal levels for estimation of umbilical cord/maternal level ratios." | 1.42 | Serum levels of valproic acid during delivery in mothers and in umbilical cord - correlation with birth length and weight. ( Brozmanova, H; Grundmann, M; Kacirova, I, 2015) |
| "VPA-induced encephalopathy is an uncommon but serious adverse effect that should be considered in patients with cognitive decline during VPA treatment." | 1.42 | [Valproate can induce reversible encephalopathy]. ( Christensen, J; Harbo, T; Prakash, S, 2015) |
| "To establish using dried blood spot (DBS) as a surrogate to plasma for therapeutic drug monitoring (TDM) of carbamazepine (CBZ), we compared the population pharmacokinetic (PPK) estimates from concurrent DBS and plasma levels." | 1.40 | Estimation and comparison of carbamazepine population pharmacokinetics using dried blood spot and plasma concentrations from people with epilepsy: the clinical implication. ( Chan, E; Ho, PC; Kong, ST; Lim, SH, 2014) |
| "The treatment profile for epilepsy, seizure control, and maternal and neonatal outcomes in both groups were compared using Chi-square test or Fisher's exact test and Mann-Whitney U test." | 1.40 | Impact of planning of pregnancy in women with epilepsy on seizure control during pregnancy and on maternal and neonatal outcomes. ( Abe, K; Hamada, H; Minakami, H; Obata-Yasuoka, M; Yamada, T; Yoshikawa, H, 2014) |
| "CNS inflammation is characterized by a disturbance of glial cell functions." | 1.40 | Glia and epilepsy: experimental investigation of antiepileptic drugs in an astroglia/microglia co-culture model of inflammation. ( Dambach, H; Faustmann, PM; Haase, CG; Hinkerohe, D; Hufnagel, A; Moinfar, Z; Prochnow, N; Stienen, MN, 2014) |
| "For patients with mental retardation or developmental delay, 25(OH)D3 levels were lower than the levels in patients with normal intelligence quotient levels (p=0." | 1.40 | Vitamin D levels in children and adolescents with antiepileptic drug treatment. ( Baek, JH; Eun, BL; Kim, GH; Kim, MK; Seo, YH, 2014) |
| "Levetiracetam treatment resulted in a decrease of the percentage of CD4(+)CD25(+)-lymphocytes (26." | 1.40 | Chronic valproate or levetiracetam treatment does not influence cytokine levels in humans. ( Bauer, S; Guenther, S; Hagge, M; Hamer, HM; Knake, S; Olmes, DG; Rosenow, F; Tackenberg, B, 2014) |
| " This type of protocol can be used to further evaluate AEDs and test effects of chronic administration of AEDs." | 1.40 | Effects of conventional anticonvulsant drugs on generalized tonic-clonic seizures in Noda epileptic rats. ( Inoue, M; Kaneko, Y; Naito, H; Noda, A; Yamamoto, A, 2014) |
| "73) in VPA-treated patients, but there were no associations with the VPA dosage or the homeostasis model assessment-estimated insulin resistance (HOMA-IR) index." | 1.40 | Comparison of the metabolic syndrome risk in valproate-treated patients with epilepsy and the general population in Estonia. ( Eglit, T; Haldre, S; Kõks, S; Lember, M; Rakitin, A, 2014) |
| "This retrospective study included 237 and 169 VPA-treated Japanese patients with epilepsy for population pharmacokinetic and pharmacokinetic-pharmacodynamic analyses, respectively." | 1.40 | Impact of the superoxide dismutase 2 Val16Ala polymorphism on the relationship between valproic acid exposure and elevation of γ-glutamyltransferase in patients with epilepsy: a population pharmacokinetic-pharmacodynamic analysis. ( Deguchi, M; Ishitsu, T; Kaneko, S; Nakagaswa, K; Nakashima, H; Nishimura, M; Noai, M; Ogusu, N; Oniki, K; Saruwatari, J; Yasui-Furukori, N, 2014) |
| "VPA-induced encephalopathy is an uncommon but serious adverse effect that should be considered in patients with cognitive decline during VPA treatment." | 1.40 | [Valproate can induce reversible encephalopathy]. ( Christensen, J; Harbo, T; Prakash, S, 2014) |
| " The symptoms of VHE were not correlated with the dosage and concentration of valproate." | 1.40 | [Clinical misdiagnosis analysis of valproate encephalopathy]. ( Chen, X; Su, Z; Wu, Z; Ye, S; Zhu, D; Zhuge, G, 2014) |
| "Hyperammonemia was defined as a plasma ammonia level exceeding 100 μg/dl with reference to the standard range and previous reports." | 1.39 | Risk factors for hyperammonemia in pediatric patients with epilepsy. ( Imai, K; Inoue, K; Inoue, Y; Itoh, K; Kagawa, Y; Mishima, N; Takahashi, Y; Yamamoto, Y; Yazawa, R, 2013) |
| "Valproate is used for the treatment of epilepsy and other neuropsychological disorders and may be the only treatment option for women of childbearing potential." | 1.39 | Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism. ( Christensen, J; Grønborg, TK; Parner, ET; Pedersen, LH; Schendel, D; Sørensen, MJ; Vestergaard, M, 2013) |
| " We report a 17-year-old man with epilepsy and Down's syndrome who experienced tremor during the treatment with a low dosage of sodium valproate." | 1.39 | Sodium valproate induced tremor in a patient with epilepsy and Down's syndrome. ( De Sarro, G; Gallelli, L; Loizzo, S; Russo, E; Siniscalchi, A; Tiziana, A, 2013) |
| "Early treatment of epilepsy is warranted to avoid possible severe consequences." | 1.39 | Epilepsy and brain injury: a case report of a dramatic neuropsychiatric vicious circle. ( Angeletti, G; Carbonetti, P; Del Casale, A; Fensore, C; Ferracuti, S; Girardi, P; Kotzalidis, GD; Lazanio, S; Muzi, A; Rapinesi, C; Savoja, V; Scatena, P; Serata, D; Tatarelli, R, 2013) |
| " The overall mean maternal valproate dosage taken by women in the Register decreased over the last 5 years of the study period." | 1.39 | Dose dependence of fetal malformations associated with valproate. ( Eadie, MJ; Graham, JE; Lander, CM; O'Brien, TJ; Vajda, FJ, 2013) |
| " The mean dosage of AED for valproate was 498 mg/day and carbamazepine was 555 mg/day." | 1.39 | Malformation in index pregnancy in women with epilepsy is not followed by recurrence in subsequent pregnancy. ( Begum, S; Sarma, SP; Thomas, SV, 2013) |
| "Epilepsy is one of the most common neurological diseases in the world." | 1.39 | [Valproic acid concentration in the blood serum of pregnant women and umbilical cord blood in relation to the condition of the newborn--case studies]. ( Breborowicz, GH; Chuchracki, M; Florek, E; Hassan-Bartz, M; Krzyścin, M; Kulza, M; Miller, R; Napierała, M; Wachowiak, A; Wozniak, A, 2013) |
| " In addition, there appeared to be a dose-response relationship between stroke risk and PHT prescriptions." | 1.39 | Comparative stroke risk of antiepileptic drugs in patients with epilepsy. ( Hsieh, CY; Lai, EC; Lin, SJ; Yang, YH, 2013) |
| "Depakote-induced hepatotoxicity has been well established as an adverse effect, and periodic monitoring of drug level is often required." | 1.38 | Thinking beyond the obvious: hepatotoxicity secondary to idiosyncratic depakote toxicity. ( Asadi, S; Avashia, KD; Chaudrey, KH; Ihsan, M; Irshad Khan, SI; Naser, TB; Nouri-Kolouri, M; Steinberg, A, 2012) |
| " Neurologists had progressively prescribed valproate less frequently and in lower dosage than other classes of practitioner over the 10-year study period, with a parallel decrease in occurrence of fetal malformations in pregnancies referred to the Register." | 1.38 | The prescribing of antiepileptic drugs for pregnant Australian women. ( Eadie, MJ; Graham, J; Hitchcock, AA; Hollingworth, S; Horgan, D; Lander, CM; O'Brien, TJ; Roten, A; Vajda, FJ, 2012) |
| "Valproic acid (VPA) is a major antiepileptic drug (AED) that is less potent than other AEDs." | 1.38 | Synthesis and anticonvulsant evaluation of dimethylethanolamine analogues of valproic acid and its tetramethylcyclopropyl analogue. ( Bialer, M; Shekh-Ahmad, T; Yavin, E, 2012) |
| "We aimed to determine cancer risk in people with epilepsy using sodium-valproate." | 1.38 | Cancer risk in people with epilepsy using valproate-sodium. ( Bell, GS; Driever, PH; Sander, JW; Singh, G, 2012) |
| "Epilepsy was confirmed by EEG and many seizures episodes were treated with different combination of anticonvulsive drugs." | 1.38 | [Epileptic asystole - a case report]. ( Bałajewicz, J; Bryniarski, L; Czamara, M; Jastrzębski, M; Kukla, P; Przyprawa, A, 2012) |
| "Phenytoin was used in 56 patients (22%) with the majority (n= 43) receiving intravenous phenytoin." | 1.38 | Seizure management at Auckland City Hospital Emergency Department between July and December 2009: time for a change? ( Bergin, P; Jones, P; Rosemergy, I; Walker, E, 2012) |
| "Epilepsy was induced by i." | 1.38 | Evaluation of the antiepileptic effect of curcumin and Nigella sativa oil in the pilocarpine model of epilepsy in comparison with valproate. ( Aboul Ezz, HS; Faraag, AR; Khadrawy, YA; Noor, NA, 2012) |
| " Moreover, a VPA dose-response curve was performed on PBMC obtained from healthy controls, demonstrating an increase of acetyl-histone H3 content." | 1.38 | Valproate induces epigenetic modifications in lymphomonocytes from epileptic patients. ( Conti, E; Difrancesco, JC; Ferrarese, C; Galimberti, G; Riva, C; Rodriguez-Menendez, V; Ruffmann, C; Tremolizzo, L, 2012) |
| "Individuals treated with combined valproate-lamotrigine rarely present late adverse effects (unrelated to introduction and titration)." | 1.38 | Late adverse effects of the coadministration of valproate and lamotrigine. ( Moreira, B; Thome-Souza, S; Valente, KD, 2012) |
| "Valproic acid was less effective in OHSCs than in the kindled seizure tests, and diazepam was more (generalized seizures) or less (focal seizures and afterdischarge durations) effective in this animal model than in OHSCs." | 1.38 | Primary afterdischarge in organotypic hippocampal slice cultures: effects of standard antiepileptic drugs. ( Albus, K; Heinemann, U; Wahab, A, 2012) |
| "He had been on a lamotrigine treatment due to epilepsy, and after cessation of lamotrigine, his cardiac enzyme levels returned to normal." | 1.38 | Lamotrigine related myocarditis: case report. ( Bayhan, T; Karagöz, T; Sahin, M; Yıldırım, I, 2012) |
| "We describe arginase deficiency in a 20-year-old woman with spastic paraplegia, progressive dystonia, dementia, peripheral neuropathy, epilepsy, liver cirrhosis, and non-B/non-C hepatocellular carcinoma." | 1.38 | Arginase deficiency with new phenotype and a novel mutation: contemporary summary. ( Ching, CK; Fung, CW; Lam, CW; Luk, HM; Mak, CM; Poon, WL; Siu, TS; Tam, S; Tsang, JP; Wong, VC, 2012) |
| "Phenobarbital has been in clinical use as an antiepileptic drug (AED) since 1912." | 1.38 | How did phenobarbital's chemical structure affect the development of subsequent antiepileptic drugs (AEDs)? ( Bialer, M, 2012) |
| " Pharmacokinetic parameters are necessary to predict the optimum therapeutic level after administration." | 1.37 | Pharmacokinetics and clinical application of intravenous valproate in Thai epileptic children. ( Bhudhisawadi, K; Chulavatnatol, S; Kaojareon, S; Vaewpanich, J; Visudtibhan, A, 2011) |
| "For unclassified epileptic seizures, no significant differences were found among the three AEDs." | 1.37 | Retrospective analysis of the effectiveness of first-line antiepileptic drugs for generalized onset and unclassified epileptic seizures in Chinese children. ( Ding, CH; Ding, YX; Fang, F; Ma, MS; Meng, LL; Wang, Y; Zou, LP, 2011) |
| " In the early phase of treatment, the main adverse effects included drowsiness, dizziness, and anorexia." | 1.37 | A 6-month prospective study on efficacy safety and QOL profiles of extended-release formulation of valproate in patients with epilepsy. ( Hong, Z; Li, T; Wang, B; Wu, XY; Xu, L; Yu, PM; Yue, L; Zhu, GX, 2011) |
| " These findings provide useful information to adjust the VPA dosage to achieve optimal therapeutic efficacy in epileptic infants." | 1.37 | Empirical approach for improved estimation of unbound serum concentrations of valproic acid in epileptic infants by considering their physical development. ( Aiba, T; Kurosaki, Y; Matsunaga, H; Ohtsuka, Y; Sato, T; Sendo, T; Ueshima, S, 2011) |
| "Two cohorts of patients with valproate-treated epilepsy and sex- and age-matched individuals (controls) from the general Danish population were identified by individual-level-linkage of nationwide registries and followed for 10 years." | 1.37 | Valproate attenuates the risk of myocardial infarction in patients with epilepsy: a nationwide cohort study. ( Abildstrøm, SZ; Andersson, C; Erdal, J; Gislason, GH; Hansen, PR; Olesen, JB; Schmiegelow, M; Torp-Pedersen, C; Weeke, P, 2011) |
| "The dominant patient was diagnosed with schizoaffective disorder and her non-dominant sister with paranoid schizophrenia." | 1.37 | Folie à deux: double case-report of shared delusions with a fatal outcome. ( Di Cosimo, D; Girardi, N; Kotzalidis, GD; Lazanio, S; Manfredi, G; Savoja, V; Talamo, A; Tatarelli, R; Vento, A, 2011) |
| "Approximately one third of newly treated epilepsy patients do not respond to antiepileptic drugs (AEDs)." | 1.37 | Lack of association of ABCB1 haplotypes on five loci with response to treatment in epilepsy. ( Haerian, BS; Lim, KS; Mohamed, EH; Mohamed, Z; Raymond, AA; Tan, CT; Tan, HJ; Wong, CP; Wong, SW, 2011) |
| "Curcumin was co-administered with sub-therapeutic dose of valproate 60min before PTZ injection." | 1.37 | Pharmacokinetic and pharmacodynamic interactions of valproate, phenytoin, phenobarbitone and carbamazepine with curcumin in experimental models of epilepsy in rats. ( Gupta, YK; Mehla, J; Pahuja, M; Reeta, KH, 2011) |
| "Valproic acid (VPA) is an anticonvulsant and mood-stabilizing drug for the long-term treatment." | 1.37 | Valproic Acid related metabolic syndrome in patients with epilepsy. ( Kasradze, S; Mania, M; Okujava, N, 2011) |
| " Plasma concentrations (pc), interactions between drugs in the ICU context, adverse effects and seizure occurrences were observed and recorded." | 1.37 | Levetiracetam compared to valproic acid: plasma concentration levels, adverse effects and interactions in aneurysmal subarachnoid hemorrhage. ( Bjeljac, M; Keller, E; Mink, S; Muroi, C; Seule, M, 2011) |
| "Treatment with curcumin, NSO or valproate ameliorated most of the changes induced by pilocarpine and restored Na⁺, K⁺-ATPase activity in the hippocampus to control levels." | 1.37 | The neuroprotective effect of curcumin and Nigella sativa oil against oxidative stress in the pilocarpine model of epilepsy: a comparison with valproate. ( Ezz, HS; Khadrawy, YA; Noor, NA, 2011) |
| "Epilepsy was confirmed in 58 cases." | 1.37 | [Epilepsy in elderly]. ( Kotov, AS; Rudakova, IG, 2011) |
| " To demonstrate a case of a 15 year old girl suffering from refractory epilepsy with underlying focal cortical dysplasia (FCD), whose seizure deterioration was most probably associated with drug-drug interactions between prescribed common antiepileptic drugs, namely valproic acid, phenobarbital or the prodrug primidon and carbamazepine." | 1.37 | Antiepleptic drug interactions: a clinical case demonstration. ( Klapková, E; Komárek, V; Tesfaye, H; Tesfayeová, A, 2011) |
| " These changes tended to parallel prescribing trends in the wider community, except for valproate, whose prescribing in the overall community increased as its prescribing, and its dosage prescribed, decreased in pregnancy." | 1.36 | Changing patterns of antiepileptic drug use in pregnant Australian women. ( Eadie, MJ; Graham, J; Hitchcock, AA; Hollingworth, S; Lander, CM; O'Brien, TJ; Vajda, FJ, 2010) |
| "Antiepileptic drugs (AEDs) have been widely used in patients with epilepsy but the adverse effects in adult Chinese patients have not been investigated." | 1.36 | Adverse effects of carbamazepine, phenytoin, valproate and lamotrigine monotherapy in epileptic adult Chinese patients. ( Wang, X; Xi, Z; Yan, Y; Zeng, K, 2010) |
| "To review our clinical experience and determine if there are appropriate signs and symptoms to consider POLG sequencing prior to valproic acid (VPA) dosing in patients with seizures." | 1.36 | POLG DNA testing as an emerging standard of care before instituting valproic acid therapy for pediatric seizure disorders. ( Bao, X; Koenig, MK; Lee, IC; Naviaux, RK; Saneto, RP; Weng, SW; Wong, LJ, 2010) |
| "Clonazepam was stopped." | 1.36 | Late-onset nocturnal intractable seizure during sleep: what is the origin? ( Liesiene, V; Miliauskas, S; Sakalauskas, R; Zemaitis, M, 2010) |
| "Weight gain was seen in 66." | 1.36 | Modification in body weight associated with antiepileptic drugs. ( Gaspari, CN; Guerreiro, CA, 2010) |
| "Epilepsy is one of the most frequent neurological diseases in the pediatric population." | 1.36 | [Characteristics of the children with epilepsy followed in the Marrakech University Hospital]. ( Amine, M; Bourrous, M; Bouskraoui, M; Draiss, G; Elibrahimi, I; Safini, F, 2010) |
| " Comparative pharmacokinetic analysis showed that α-Cl-TMCD is less susceptible to liver first-pass effect than α-F-TMCD because of lower total (metabolic) clearance and liver extraction ratio." | 1.36 | Comparative pharmacodynamic and pharmacokinetic analysis of two anticonvulsant halo derivatives of 2,2,3,3-tetramethylcyclopropanecarboxamide, an amide of a cyclic analog of valproic acid. ( Bialer, M; Finnell, RH; Hen, N; Kaufmann, D; Pessah, N; Wlodarczyk, B; Yagen, B, 2010) |
| "Epilepsy was diagnosed in 37% (375/1014) of the study participants." | 1.36 | Correlation between EEG abnormalities and symptoms of autism spectrum disorder (ASD). ( Yasuhara, A, 2010) |
| "Antiepileptic drugs (AED) as transplacental agents are known to have adverse effects on fetal development." | 1.36 | Transplacental genotoxicity of antiepileptic drugs: animal model and pilot study on mother/newborn cohort. ( Bakulic, TI; Demarin, V; Fucic, A; Gjergja, R; Jazbec, AM; Katic, J; Markovic, D; Miškov, S; Stojković, R; Zeljezic, D, 2010) |
| "The aim of the present study was to build population pharmacokinetic models for the clearance of valproate (VPA) in 2 separate populations of Serbian patients with epilepsy, children and adults." | 1.36 | Factors influencing valproate pharmacokinetics in children and adults. ( Jankovic, S; Jankovic, SM; Milovanovic, JR, 2010) |
| " Sodium valproate was administered at the dosage of 10-30 mg/kg/d." | 1.35 | [Influence of age, body weight and dose on sodium valproate plasma concentrations in children with epilepsy]. ( Jiang, Z; Liao, HM; Peng, QL; Tang, JW; Zhang, J, 2008) |
| "Valproic acid was the most frequently prescribed drug, followed by carbamazepine and lamotrigine." | 1.35 | Antiepileptic drug utilization in children from 1997-2005--a study from the Netherlands. ( Brouwer, OF; de Jong-van den Berg, LT; de Vries, TW; van de Vrie-Hoekstra, NW; van den Berg, PB, 2008) |
| "(2007) Seizure suppression by top1 mutations in Drosophila." | 1.35 | DNA topoisomerase I inhibitors ameliorate seizure-like behaviors and paralysis in a Drosophila model of epilepsy. ( Hormozi, L; Parker, L; Song, J; Tanouye, MA, 2008) |
| "Efficacy of seizure control was considered satisfactory if there was a reduction in seizures>50% or total control." | 1.35 | Association of lamotrigine and valproate in refractory epilepsies of children and adolescents. ( Antoniuk, SA; Bruck, I; Grisotto, KP; Santos, LH, 2008) |
| "Valproic acid (VPA) is a widely used and well-tolerable antiepileptic drug in epileptic patients." | 1.35 | The effects of biotin supplementation on serum and liver tissue biotinidase enzyme activity and alopecia in rats which were administrated to valproic acid. ( Akin, R; Arslan, M; Balamtekin, N; Kurt, I; Ozcan, O; Unay, B; Vurucu, S, 2009) |
| "Our findings suggest that hair loss in patients can be attributed to zinc and BA depletion within the first 3 months, and to zinc depletion only by the 6th month." | 1.35 | The influence of valproic acid treatment on hair and serum zinc levels and serum biotinidase activity. ( Paksu, MS; Tasdemir, HA; Yilmaz, Y, 2009) |
| "Early epilepsy is known to worsen the developmental prognosis of young children with a congenital focal brain lesion, but its direct role is often very difficult to delineate from the other variables." | 1.35 | The role of epilepsy in early language development in a child with a congenital lesion in the right hemisphere. ( Deonna, T; Maeder-Ingvar, M; Mayor-Dubois, C; Roulet-Perez, E, 2008) |
| "Total body weight, daily dose of valproate and concomitant therapy with PB are factors that significantly influence VPA kinetic disposition and they should be considered in programming dosage regimens for this antiepileptic drug in the pediatric population." | 1.35 | Population pharmacokinetics of valproate in Mexican children with epilepsy. ( Correa, T; Rodríguez, I; Romano, S, 2008) |
| "The purpose of this study was to perform population pharmacokinetic (PPK) analysis on carbamazepine and to determine the population model of clearance of this drug in terms of individual patient characteristics." | 1.35 | Pharmacokinetic modeling of carbamazepine based on clinical data from Serbian epileptic patients. ( Jankovic, SM; Jovanovic, D; Milovanovic, JR, 2008) |
| " These findings showed that with a much lower dosage of the drugs, which is suggested in texts can lead to an appropriate blood level of CBZ and VPA for controlling the epileptic seizures." | 1.35 | An experimental design for finding of minimum dosage of carbamazepine and valproate in preventing of seizure attacks. ( Nobahar, M; Samaei, A; Vafaei, AA, 2009) |
| "To characterize the interaction between tiagabine (TGB) and valproate (VPA)--two antiepileptic drugs in the mouse pentylenetetrazole (PTZ)-induced clonic seizure model, type I isobolographic analysis for non-parallel dose-response relationship curves (DRRCs) was used." | 1.35 | Interaction of tiagabine with valproate in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves. ( Krzyzanowski, M; Luszczki, JJ; Swiader, MJ, 2009) |
| "Epilepsy was most common among those with maternal deletions and unknown subtypes, with catastrophic epilepsies present in only these two subtypes." | 1.35 | Epilepsy in Angelman syndrome: a questionnaire-based assessment of the natural history and current treatment options. ( Braun, EK; Bruno, P; Conant, KD; Nespeca, MP; Said, RR; Thibert, RL; Thiele, EA, 2009) |
| "A total of 344 patients became seizure-free with the first prescribed antiepileptic drug." | 1.35 | Effectiveness of the first antiepileptic drug in the treatment of pediatric epilepsy. ( Ding, CH; Ding, YX; Fang, F; Ma, MS; Ying, W; Zou, LP, 2009) |
| "Epilepsy is often the most important clinical manifestation of the syndrome, even if its appearance is not constantly precocious." | 1.35 | Ring chromosome 20 syndrome: a link between epilepsy onset and neuropsychological impairment in three children. ( Canevini, MP; Dalla Bernardina, B; Darra, F; Fiorini, E; La Selva, L; Lazzarotto, F; Piazzini, A; Vignoli, A; Zucca, C, 2009) |
| " Limbic (psychomotor) seizure activity was evoked in albino Swiss mice by a current (32 mA, 6 Hz, 3s stimulus duration) delivered via ocular electrodes and isobolographic analysis for parallel and non-parallel dose-response effects was used to characterize the consequent anticonvulsant interactions between the various drug combinations." | 1.35 | Isobolographic characterization of interactions of levetiracetam with the various antiepileptic drugs in the mouse 6 Hz psychomotor seizure model. ( Luszczki, JJ; Patsalos, PN; Wlaz, A; Wojda, E, 2009) |
| "In this study 27 patients with focal or generalized epilepsy receiving a single dosage of prolonged-release valproate given in the evening were included." | 1.35 | Once daily monotherapy with prolonged-release valproate minitablets given in the evening--a chronopharmacological study. ( Fraunberger, B; Graf, W; Kerling, F; Pauli, E; Stefan, H; Yang, T, 2009) |
| " In patients with heterozygote (MTHFR) 677C/T polymorphism and under long-term use of certain drugs the determination of Hcy plasma levels may be useful to prevent the development of atherothrombotic disease." | 1.35 | Na VPA-induced acute ischemic stroke in an epileptic patient with methylenetetrahydrofolate reductase gene polymorphism. ( Varoglu, AO, 2009) |
| "To evaluate the effects of CYP2C19 and CYP2C9 genotypes on the pharmacokinetic variability of valproic acid (VPA) in epileptic patients using a population pharmacokinetic (PPK) approach." | 1.35 | Effects of CYP2C19 and CYP2C9 genotypes on pharmacokinetic variability of valproic acid in Chinese epileptic patients: nonlinear mixed-effect modeling. ( Bai, X; Jiang, D; Li, L; Lu, W; Müller, M; Wang, Y; Zhang, Q, 2009) |
| " We predict that excursions beyond the conventional recommended VPA plasma concentration range will commonly occur with high total mg daily doses (>or=2000 mg) of enteric-coated divalproex, if dosed once-daily, potentially producing clinical toxicity." | 1.35 | Once-daily dosing is appropriate for extended-release divalproex over a wide dose range, but not for enteric-coated, delayed-release divalproex: evidence via computer simulations and implications for epilepsy therapy. ( Dutta, S; Liu, W; Reed, RC, 2009) |
| " TDM requests, interpretation and dosage adjustment recommendations were mainly responsible by residents." | 1.35 | Effect of pharmacist participation in the health care team on therapeutic drug monitoring utilization for antiepileptic drugs. ( Faroongsarng, D; Kaewpibal, P; Ratanajamit, C; Setthawacharavanich, S, 2009) |
| "Epilepsy has been associated with poor obstetric outcomes that could be the result of the epilepsy itself or a direct effect of anti-epileptic medication on placentation." | 1.35 | Phenytoin but not valproate directly affected in vitro trophoblast differentiation. ( Anin, S; Bates, MD; Chadwick, D; Neilson, JP; Quenby, SM; Vince, GS, 2008) |
| "Visual auras are reported to be uncommon or rare in patients with idiopathic generalized epilepsy." | 1.35 | [Visual auras in idiopathic generalized epilepsy]. ( Coubes, P; Crespel, A; Gelisse, P, 2008) |
| "Epilepsy is a major public health problem affecting nearly 50 million people world wide." | 1.35 | Fish liver oil and propolis as protective natural products against the effect of the anti-epileptic drug valproate on immunological markers of bone formation in rats. ( El Elshamy, KA; Elwakkad, AS; Sibaii, H, 2008) |
| "The odds of having parkinsonism were 5 times higher with valproate than with other AEDs." | 1.34 | Movement disorders in patients taking anticonvulsants. ( Asante, AN; Carlen, P; Lang, A; Munhoz, RP; Politzer, N; Wennberg, R; Zadikoff, C, 2007) |
| "Epilepsy is one of the most common presentations of patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS)." | 1.34 | Valproic acid aggravates epilepsy due to MELAS in a patient with an A3243G mutation of mitochondrial DNA. ( Lin, CM; Thajeb, P, 2007) |
| "We diagnosed interstitial pneumonitis (IP) based on her chest CT and high serum concentrations of KL-6 and surfactant protein D." | 1.34 | [Valproate sodium and zonisamide associated interstitial pneumonitis in an infant]. ( Doi, T; Kato, T; Nikaido, K; Takayama, R, 2007) |
| " Relation could not be established between the duration of VPA therapy, dosage of the drug, blood level of drug, age and sex of the patients and the auditory signs." | 1.34 | Effects of valproic acid on hearing in epileptic patients. ( Akoglu, E; Duman, T; Incecik, F; Melek, I; Sangün, O, 2007) |
| " The pharmacokinetics of the 260 PB concentrations at a steady-state obtained from 79 patients was described with a one-compartment open pharmacokinetic model with first-order elimination." | 1.34 | Population estimation of the effects of cytochrome P450 2C9 and 2C19 polymorphisms on phenobarbital clearance in Japanese. ( Goto, S; Ishitsu, T; Murata, T; Nakada, N; Nakagawa, K; Seo, T; Ueda, N, 2007) |
| " No correlation was found between duration or dosage of treatment and BMI-SDS, height-SDS, or androgen level." | 1.34 | Endocrine effects of valproate in adolescent girls with epilepsy. ( de Vries, L; Goldberg-Stern, H; Karasik, A; Kiviti, S; Landau, Z; Phillip, M, 2007) |
| "Myo-inositol was found to be lower while taking VPA, although no relationship between the change in metabolite concentration, VPA dose or seizure control was observed." | 1.34 | The effect of sodium valproate on proton MRS visible neurochemical concentrations. ( Barker, GJ; Duncan, JS; McLean, MA; Simister, RJ, 2007) |
| "This means that seizures do not arise de novo in the seizure focus." | 1.34 | Temporal lobe epilepsy is a disease of faulty neuronal resonators rather than oscillators, and all seizures are provoked, usually by stress. ( Eggers, AE, 2007) |
| "Metabolic syndrome was more frequently associated with VPA-treated patients (41." | 1.34 | Metabolic and hormonal disturbances in women with epilepsy on antiepileptic drug monotherapy. ( Kim, JY; Lee, HW, 2007) |
| "Valproic acid (VPA) is an antiepileptic drug frequently used in children." | 1.34 | Severe bleeding complications during antiepileptic treatment with valproic acid in children. ( Albisetti, M; Cannizzaro, E; Schmugge, M; Wohlrab, G, 2007) |
| "Lamotrigine was escalated according to a target dose of 200 mg/day over 8-weeks." | 1.34 | Conversion to lamotrigine monotherapy from valproate monotherapy in older adolescent patients with epilepsy. ( Baumann, RJ; Fakhoury, TA; Hammer, AE; Kustra, RP; Messenheimer, JA; Vuong, A, 2007) |
| "The aim of the present study is to establish a population pharmacokinetic (PPK) model of valproate (VPA) in Chinese epileptic children to promote the reasonable use of anti-epileptic drugs." | 1.34 | Population pharmacokinetics of valproate in Chinese children with epilepsy. ( Bai, XR; Jiang, DC; Li, L; Lu, W; Wang, L; Wang, YQ, 2007) |
| " Both volume and absorption rate constant were fixed (14 L and 1 hr, respectively)." | 1.34 | Population pharmacokinetics of valproic acid concentrations in elderly nursing home residents. ( Ahn, JE; Birnbaum, AK; Brundage, RC; Conway, JM; Hardie, NA; Leppik, IE, 2007) |
| " Fluorescence polarization immunoassay (FPIA) was used to measure the serum concentration of sodium valproate and the results were standardized by dosage and body weight." | 1.34 | [Effect of UGT1A6 genetic polymorphisms on the metabolism of sodium valproate]. ( Song, JH; Sun, YP; Tan, L; Wang, Y, 2007) |
| "The aim of this study was to define a population pharmacokinetic model that could estimate the clearance of valproate (VPA) in a Serbian epileptic population." | 1.34 | Pharmacokinetic modeling of valproate from clinical data in Serbian epileptic patients. ( Jankovic, SM; Milovanovic, JR, 2007) |
| " There is an ongoing debate whether this can be attributed to chronic use of antiepileptic drugs or to the epilepsy itself." | 1.33 | Antiepileptic drugs alter reproductive endocrine hormones in men with epilepsy. ( Bjørnenak, T; Gjerstad, L; Mørkrid, L; Mørland, T; Røste, LS; Saetre, ER; Taubøll, E, 2005) |
| "Primary Sjogren syndrome is considered as the most frequent connective tissue disease." | 1.33 | [Sjögren's syndrome with autonomic failure and epilepsy]. ( Attout, H; Guez, S; Martre, A; Series, C, 2005) |
| "Valproic acid has been previously associated with hematologic toxicity, including a reversible myelodysplasia-like syndrome without chromosomal abnormalities." | 1.33 | Acute leukemia associated with valproic acid treatment: a novel mechanism for leukemogenesis? ( Bair, AK; Coyle, TE; Mehdi, S; Stein, C; Vajpayee, N; Wright, J, 2005) |
| "To report a pharmacokinetic interaction between valproic acid (VPA) and anticancer agents observed in an epileptic patient." | 1.33 | Pharmacokinetic interaction on valproic acid and recurrence of epileptic seizures during chemotherapy in an epileptic patient. ( Ikeda, H; Kihira, K; Murakami, T; Takano, M; Usui, T, 2005) |
| " VPA was not found to have any clinically significant influence on TPM pharmacokinetic and metabolic profiles." | 1.33 | A comparative study of the effect of carbamazepine and valproic acid on the pharmacokinetics and metabolic profile of topiramate at steady state in patients with epilepsy. ( Bialer, M; Britzi, M; Doose, DR; Gatti, G; La Neve, A; Levy, RH; Maryanoff, BE; Mimrod, D; Perucca, E; Soback, S; Specchio, LM; Specchio, N, 2005) |
| " Unlike the situation for the other drugs, the malformation rate in those exposed to valproate increased with increasing maternal drug dosage (P<0." | 1.33 | Maternal valproate dosage and foetal malformations. ( Eadie, MJ; Vajda, FJ, 2005) |
| " No tolerance was evident in the intravenous pentylenetetrazol test after twice-daily dosing of ABT-769 (0." | 1.33 | Preclinical profiling and safety studies of ABT-769: a compound with potential for broad-spectrum antiepileptic activity. ( Bennani, Y; Bitner, RS; Chemburkar, SR; Chen, J; Curzon, P; Dart, MJ; Decker, MW; Durmuller, N; Fox, GB; Giardina, WJ; Grayson, GK; Harris, RR; Hui, JY; Jolly, R; Komater, VA; Ku, Y; Lockwood, M; Marsh, KC; Miner, HM; Nikkel, AL; Pan, JB; Pu, YM; Radek, RJ; Roux, S; Sullivan, JP; Wang, L; Waring, JF, 2005) |
| " Adverse events and reasons for terminating the diet were tabulated." | 1.33 | Safety and tolerability of the ketogenic diet in pediatric epilepsy: effects of valproate combination therapy. ( Ghosh, S; Lyczkowski, DA; Pfeifer, HH; Thiele, EA, 2005) |
| "A 56-year-old woman with poorly controlled epilepsy, receiving valproate at subtherapeutic levels for 6 years, developed a life-threatening hyperammonemic coma following a moderate dosage increase." | 1.33 | Acute hyperammonemic coma with chronic valproic acid therapy. ( Abramson, RK; Cuturic, M, 2005) |
| "Lamotrigine (LTG) was prescribed in 29 patients as add-on therapy." | 1.33 | The use of lamotrigine and other antiepileptic drugs in paediatric patients at a Malaysian hospital. ( Ab Rahman, AF; Ibrahim, MI; Ismail, HI; Seng, TB, 2005) |
| "Oxcarbazepine is an antiepileptic drug widely used to treat partial seizures in children and adults." | 1.33 | Possible precipitation of myoclonic seizures with oxcarbazepine. ( Holmes, GL; Kaddurah, AK, 2006) |
| "Ten cases of reversible parkinsonism associated with VPA in 6 women and 4 men, associated with marked cognitive impairment in six cases, are described." | 1.33 | Parkinsonism and/or cognitive impairment with valproic acid therapy: a report of ten cases. ( Andréjak, M; Gras-Champel, V; Masmoudi, K; Masson, H, 2006) |
| "1% and never over taking dosed the antiepileptic drug 96." | 1.33 | Chrono impact versus enteric coated valproate in Thai epileptic patients. ( Arayawichanon, A; Asawavichenjinda, T; Chaisewikul, R; Kijjarak, R; Maneesuk, S; Poungvarin, N; Silpakit, O; Sirimaharaj, S; Thammasupapong, S; Tiemkao, S; Towanabut, S, 2005) |
| "Weight gain is a known side effect of valproate (VPA) therapy, which is associated with hyperinsulinemia and polycystic ovary-like syndrome and unfavorable lipid changes in women." | 1.33 | Insulin-related metabolic changes during treatment with valproate in patients with epilepsy. ( Isojärvi, J; Knip, M; Pakarinen, A; Pylvänen, V, 2006) |
| "Women with epilepsy have a higher risk of having dysmorphic child." | 1.33 | A case of fetal anticonvulsant syndrome with severe bilateral upper limb defect. ( Batukan, C; Ceylaner, G; Ceylaner, S; Guven, MA; Uzel, M, 2006) |
| " Conversely, for divalproex-ER dosed once-daily in the evening, for example 8 PM, a blood draw 12 to 15 hours later (ie, 8 to 11 AM) will give a plasma VPA concentration value that is 18% to 25% higher, on average, than the trough value." | 1.33 | Does it really matter when a blood sample for valproic acid concentration is taken following once-daily administration of divalproex-ER? ( Dutta, S; Reed, RC, 2006) |
| "Valproic acid (VPA) is an antiepileptic drug (AED) commonly used for generalized and focal epilepsies." | 1.33 | Valproate-associated coagulopathies are frequent and variable in children. ( Bell, N; Brand, J; Dempfle, CE; Gerstner, T; König, S; Longin, E; Teich, M, 2006) |
| "Treatment with valproic acid decreased the complaints." | 1.33 | Autonomic headache with autonomic seizures: a case report. ( Kaleagasi, H; Ozge, A; Yalçin Tasmertek, F, 2006) |
| " At many institutes, especially children are treated as inpatients until the desired dosage is reached." | 1.33 | Oral rapid loading of valproic acid--an alternative to the usual saturation scheme? ( Bell, N; Gerstner, T; König, SA; Longin, E, 2006) |
| "If lamotrigine (LTG) has to be replaced with valproate (VPA), this exchange may be complicated by adverse events that result from the complex interaction of both drugs." | 1.33 | How to replace lamotrigine with valproate. ( Steinhoff, BJ, 2006) |
| "Valproic acid (VPA) is an antiepileptic drug (AED) commonly used for generalized and focal epilepsies." | 1.33 | Valproic acid-induced hepatopathy: nine new fatalities in Germany from 1994 to 2003. ( Borusiak, P; Boxtermann, W; Brückner, R; Buesing, D; Degen, I; Degenhardt, V; Fitzek, S; Gerstner, T; Haensch, CA; Hanusch, R; Hartmann, M; Häussermann, P; Hoppen, T; Jungck, A; Kasper, JM; Kluger, G; Knapp, R; Koenig, SA; Korenke, GC; Kuhn, H; Lindmayer, F; Longin, E; Müller-Deile, A; Oehring, R; Richard, HH; Samii, K; Seitz, R; Specht, U; Weber, Y; Weidner, B, 2006) |
| "Valproic acid (VPA) has a narrow therapeutic range (50-100mg/l) and exhibits nonlinear protein binding." | 1.32 | Oral/intravenous maintenance dosing of valproate following intravenous loading: a simulation. ( Cloyd, JC; Collins, SD; Dutta, S; Granneman, GR, 2003) |
| "Valproic acid (VPA) is an antiepileptic drug (AED) used for generalized and absence seizures." | 1.32 | Effects of age and polytherapy, risk factors of valproic acid (VPA) hepatotoxicity, on the excretion of thiol conjugates of (E)-2,4-diene VPA in people with epilepsy taking VPA. ( Abbott, F; Farrell, K; Gopaul, S, 2003) |
| " We performed a cross-sectional surveillance study on pediatric patients taking valproate to evaluate the relationship between carnitine levels and demographic data including age, daily dosage of valproate, number of antiepileptic drugs, body mass index, and feeding problems." | 1.32 | Carnitine level in Chinese epileptic patients taking sodium valproate. ( Fok, TF; Fung, EL; Ho, CS; Lam, CW; Tang, NL, 2003) |
| "We studied 14 patients with juvenile myoclonic epilepsy (JME), 19 patients with refractory localization-related epilepsy (RLE) and 20 healthy volunteers who were matched for age and sex." | 1.32 | Uptake of GABA and activity of GABA-transaminase in platelets from epileptic patients. ( Keränen, T; Peltola, J; Rainesalo, S; Saransaari, P, 2003) |
| "Hyperandrogenism was not found in valproate-treated boys." | 1.32 | [Effects of valproate on sexual development]. ( Andrés Celma, M; Balaguer Martínez, JV; Castelló Pomares, ML; Contell Villagrasa, A; López García, MJ, 2003) |
| "Intravenous VPA loading is safe and effective for treating acute seizure emergencies in children." | 1.32 | Safety and efficacy of intravenous valproate in pediatric status epilepticus and acute repetitive seizures. ( Cunanan, C; Mills, S; Thompson, N; Yu, KT, 2003) |
| "Carbamazepine (CBZ) was used in seven patients at the onset of AS." | 1.32 | Absence seizures in patients with localization-related epilepsy. ( Hayakawa, F; Nakai, Y; Negoro, T; Okumura, A; Sofue, A; Toyota, N; Watanabe, K, 2003) |
| "Men with epilepsy are known to have reduced fertility." | 1.32 | Alterations in semen parameters in men with epilepsy treated with valproate or carbamazepine monotherapy. ( Bjørnenak, T; Gjerstad, L; Haugen, TB; Røste, LS; Saetre, ER; Taubøll, E, 2003) |
| "The incidence of birth defects in relation to specific AEDs was: valproate (16." | 1.32 | The Australian registry of anti-epileptic drugs in pregnancy: experience after 30 months. ( Graham, J; Hitchcock, A; Lander, C; O'Brien, TJ; Vajda, FJ, 2003) |
| "Pregnancy was otherwise uneventful." | 1.32 | Multiple congenital malformations including generalized hypertrichosis with gum hypertrophy in a child exposed to valproic acid in utero. ( Audeoud, F; Bernardin, A; Gaugler, C; Messer, J; Stoll, C, 2003) |
| "The uric acid level was significantly decreased in group A compared with group B (p < 0." | 1.32 | Hypouricemia in severely disabled children II: influence of elemental enteral nutrition on the serum uric acid levels. ( Abe, T; Yamazaki, S; Yoshikawa, H, 2004) |
| "One hundred seventy-eight men had focal epilepsy (117 of these had temporal lobe epilepsy [TLE]) and 22 idiopathic generalized epilepsy (IGE)." | 1.32 | Epilepsy syndrome, focus location, and treatment choice affect testicular function in men with epilepsy. ( Bauer, J; Blumenthal, S; Reuber, M; Stoffel-Wagner, B, 2004) |
| "Men with epilepsy have reduced fertility, and antiepileptic drugs may affect semen quality." | 1.32 | Effect of epilepsy and antiepileptic drugs on male reproductive health. ( Isojärvi, JI; Juntunen, KS; Löfgren, E; Päivänsalo, M; Pakarinen, AJ; Rautakorpi, I; Tuomivaara, L, 2004) |
| "Polycystic ovary syndrome was more common in patients on medication (38%; in 63% on VPA, in 25% on other medication) than in patients off medication (6%) or in controls (11%) (p = 0." | 1.32 | Long-term reproductive endocrine health in young women with epilepsy during puberty. ( Isojärvi, JI; Järvelä, IY; Knip, M; Mikkonen, K; Pakarinen, AJ; Tapanainen, JS; Vainionpää, LK, 2004) |
| "The average annual cost of outpatient treatment of epilepsy was found to be 47 US dollars per patient." | 1.32 | Cost of epilepsy in patients attending a secondary-level hospital in India. ( Kapoor, SK; Krishnan, A; Sahariah, SU, 2004) |
| " However, there is no information available on the number of therapeutic abortions, or the different types of epilepsy or drug dosage in the two treatment groups." | 1.32 | Major malformations in infants exposed to antiepileptic drugs in utero, with emphasis on carbamazepine and valproic acid: a nation-wide, population-based register study. ( Källén, B; Wide, K; Winbladh, B, 2004) |
| "001) difference in median values of the absorption rate constant was found between enteric-coated and sustained-release VAL formulations." | 1.32 | Nonparametric population modeling of valproate pharmacokinetics in epileptic patients using routine serum monitoring data: implications for dosage. ( Bondareva, IB; Jelliffe, RW; Sokolov, AV; Tischenkova, IF, 2004) |
| "Valproic acid pharmacokinetic profile and tolerability after administration of divalproex sodium extended-release tablets was characterized in older children and adolescents." | 1.32 | Divalproex-ER pharmacokinetics in older children and adolescents. ( Biton, V; Conway, JM; Dutta, S; Kearns, GL; Reed, MD; Sallee, FR; Zhang, Y, 2004) |
| "The aims of our study were to evaluate whether deficits in color vision exist in epileptic adolescents, to study if monotherapy with valproic acid (VPA) and carbamazepine (CBZ) can affect color vision, and to determine the possible relationship between abnormal color vision tests and AEDs dosage and their serum concentrations." | 1.32 | Color vision in epileptic adolescents treated with valproate and carbamazepine. ( Chiarelli, F; Gallenga, PE; Lobefalo, L; Morgese, G; Priolo, T; Rapinese, M; Trotta, D; Verrotti, A, 2004) |
| " The severity of the cognitive side effects of TPM may be related to dosing to a certain extent, but this relationship may be disclosed only with larger sample sizes." | 1.32 | Cognitive profile of topiramate as compared with lamotrigine in epilepsy patients on antiepileptic drug polytherapy: relationships to blood serum levels and comedication. ( Elger, CE; Helmstaedter, C; Kockelmann, E, 2004) |
| " Recently, a new extended-release (ER) formulation of divalproex sodium has become available, which allows for once-daily dosing and provides prolonged therapeutic serum levels." | 1.32 | Clinical comparison of extended-release divalproex versus delayed-release divalproex: pooled data analyses from nine trials. ( Centorrino, F; Collins, MA; Smith, MC; Welge, JA, 2004) |
| "We describe the incidence of newly treated epilepsy in primary care and patterns of antiepileptic drug prescription, numbers of patients who remain on initial therapy and health service utilisation." | 1.32 | The outcome of initiation of antiepileptic drug monotherapy in primary care: a UK database survey. ( Buchan, S; Kerr, MP; Morgan, CL, 2004) |
| "Using sparse data of valproate (VPA) serum concentrations to build a population pharmacokinetic (PPK) model of VPA in Chinese children with epilepsy and to predict serum concentrations for new patients using a Bayesian approach." | 1.32 | Population pharmacokinetic model of valproate and prediction of valproate serum concentrations in children with epilepsy. ( Jiang, DC; Wang, L, 2004) |
| "Since Fanconi syndrome was considered to be caused by sodium valproate, it was stopped." | 1.31 | Fanconi syndrome caused by sodium valproate: report of three severely disabled children. ( Abe, T; Watanabe, T; Yoshikawa, H, 2002) |
| "Despite the frequency of seizure disorders in the human population, the genetic basis for these defects remains largely unclear." | 1.31 | Anticonvulsant valproate reduces seizure-susceptibility in mutant Drosophila. ( Kuebler, D; Tanouye, M, 2002) |
| "To determine population-based pharmacokinetic parameters for intravenous valproic acid, and the factors influencing these parameters, in Korean adults." | 1.31 | Population pharmacokinetics of intravenous valproic acid in Korean patients. ( Kang, SS; Kim, ON; Lee, SB; Lee, YB; Park, HM; Shin, DJ; Yim, DS, 2002) |
| "Landau-Kleffner syndrome is marked by an acquired aphasia in children who have had normal language and motor development." | 1.31 | Landau-Kleffner syndrome beginning with stuttering: case report. ( Kadioğlu, B; Serdaroğlu, G; Tütüncüoğlu, S, 2002) |
| "Determining antiepileptic drug (AED) concentration in biological fluids and calculating its dosage on this basis is a long-term method in the treatment of epilepsy." | 1.31 | [Therapeutic antiepileptic drug monitoring: thirteen years of experience in the Laboratory of Clinical Neuropharmacology in the Chair and Department of Developmental neurology]. ( Galas-Zgorzalewicz, B; Steinborn, B, 2000) |
| " Everyone received a drug dosage which gave an adequate therapeutic plasma concentration and satisfactory seizure control." | 1.31 | [Bimodal evoked potentials during long-term therapy with conventional or slow release preparations of carbamazepine and valproic acid in children and adolescents with epilepsy]. ( Zgorzalewicz, M, 2000) |
| " In this study, we examined the anticonvulsant and adverse effects of the three clinically established AEDs carbamazepine (CBZ), phenobarbital (PB), and valproate (VPA) once per month in the same two groups of amygdala-kindled rats over a period of 9 (group 1) or 6 (group 2) consecutive months." | 1.31 | Repeated acute testing of anticonvulsant drugs in amygdala kindled rats: increase in anticonvulsant but decrease in adverse effect potential. ( Fiedler, M; Löscher, W, 2000) |
| "Carnitine is an nonproteic nitrogenated compound acid present in all mammalian tissue and its principal activity is the long-chain fatty acid transport across the mitochondrial membrane for beta-oxidation." | 1.31 | [Antiepileptic drugs and carnitine]. ( Artuch, R; Campistol, J; Chávez, B; Vilaseca, MA, 2000) |
| "The course of epilepsy is more difficult to predict, but failure to respond to the first AED is worrisome." | 1.31 | Prognosis of seizures occurring in the first year. ( Datta, AN; Wirrell, EC, 2000) |
| "Carbamazepine treatment alters the serum lipid profile of the children in such a way that it facilitates the development of atherosclerosis." | 1.31 | Carbamazepine and valproic acid: effects on the serum lipids and liver functions in children. ( Demircioğlu, S; Dirik, E; Soylu, A, 2000) |
| "Valproic acid was converted directly into its pentafluorobenzyl ester derivative without the need to perform any extraction from the biologic fluid." | 1.31 | Assessment of drug concentrations in tears in therapeutic drug monitoring: I. Determination of valproic acid in tears by gas chromatography/mass spectrometry with EC/NCI mode. ( Honda, A; Kitagawa, S; Miyamoto, J; Miyazaki, H; Nakajima, M; Ohya, M; Sato, S; Shimada, K; Shoda, J; Yamato, S, 2000) |
| " As increasing numbers of bipolar patients are in long-term treatment with valproate, there is an important need for further research that clarifies the relationship between long-term administration of valproate and other mood stabilizers and the potential development of reproductive endocrinologic abnormalities, and for increased awareness among clinicians and patients of the unknown potential for these worrisome side-effects." | 1.31 | Valproate treatment and the risk of hyperandrogenism and polycystic ovaries. ( Soares, JC, 2000) |
| "Autism has been described in association with a variety of medical and genetic conditions." | 1.31 | Fetal valproate syndrome and autism: additional evidence of an association. ( Cunningham, M; Hersh, JH; Kerr, B; King, J; Stephan, M; Williams, G, 2001) |
| " To avoid complex pharmacokinetic interactions among multiple antiepileptic drugs, the data on serum concentrations in the current study were collected from patients who were co-administered only one additional antiepileptic drug (phenobarbital-carbamazepine, phenobarbital-valproic acid, or carbamazepine-valproic acid) or who received monotherapy." | 1.31 | Pharmacokinetic interactions among phenobarbital, carbamazepine, and valproic acid in pediatric Japanese patients: clinical considerations on steady-state serum concentration-dose ratios. ( Aoyama, T; Higuchi, S; Hokazono, T; Ohdo, S; Satou, M; Yukawa, E, 2000) |
| "A possible role of the seizure disorder or, alternatively, of the use of antiepileptic drugs (AEDs) has been suggested as the pathogenic mechanism." | 1.31 | Characterization of reproductive endocrine disorders in women with epilepsy. ( Bilo, L; Di Carlo, C; Meo, R; Nappi, C; Striano, S; Valentino, R, 2001) |
| "Ideally any pregnancy in a woman being treated for epilepsy should be planned, and both an obstetrician and a neurologist should be consulted." | 1.31 | Craniosynostosis and fetal exposure to sodium valproate. ( Barcik, U; Bourgeois, M; El Ghouzzi, V; Lajeunie, E; Renier, D; Thorne, JA, 2001) |
| "Carbamazepine and depakine treatment during at least 6 months does not predispose to ovary polycystosis syndrome." | 1.31 | [The pharmacological and hormonal effects of carbamazepine and valproic acid in the treatment of reproductive age women with epilepsy]. ( Karlov, VA; Kushlinskiĭ, NE; Vlasov, PN, 2001) |
| "In our study, we report a patient having head trauma history with partial and secondary generalized seizures taking 1500 mg/day valproate." | 1.31 | Reversible valproate-induced choreiform movements. ( Bingol, CA; Guleryuz, M; Gunal, DI, 2002) |
| "Clobazam is a 1,5-benzodiazepine effective in antiepileptic therapy of children and adults." | 1.30 | Interactions of clobazam with conventional antiepileptics in children. ( Cortez, M; Daneman, R; Hwang, P; Koren, G; Menzano, E; Sherwin, AL; Theis, JG, 1997) |
| "Treatment with carbamazepine decreased plasma OE1S levels from a mean value of 810." | 1.30 | Differential effect of carbamazepine and valproate monotherapy on plasma levels of oestrone sulphate and dehydroepiandrosterone sulphate in male epileptic patients. ( Berntsen, H; Engelsen, BA; Geisler, J; Geisler, S; Lønning, PE, 1997) |
| " The purpose of our study was to evaluate the effects of chronic administration of valproate (VPA), phenytoin (PHT), and MK-801 on the change in seizure phenotype observed in our model system." | 1.30 | Effects of valproate, phenytoin, and MK-801 in a novel model of epileptogenesis. ( Applegate, CD; Ozduman, K; Samoriski, GM, 1997) |
| "Valproic acid is an antiepileptic drug in widespread use." | 1.30 | Thrombocytopenic purpura and anemia in a breast-fed infant whose mother was treated with valproic acid. ( Neiderud, J; Stahl, MM; Vinge, E, 1997) |
| " AWD 140-190 thus presents an orally active and safe anticonvulsant agent, which is structurally unrelated to anticonvulsants currently used." | 1.30 | AWD 140-190: a new anticonvulsant with a very good margin of safety. ( Bartsch, R; Engel, J; Rostock, A; Rundfeldt, C; Tober, C; Unverferth, K; White, HS; Wolf, HH, 1997) |
| "Valproic acid (VPA) is an antiepileptic drug widely used in paediatrics." | 1.30 | [Evaluation of the effect of long term valproic acid treatment on plasma levels of carnitine, ammonia and amino acids related to the urea cycle in pediatric epileptic patients]. ( Jiménez, C; Lluch-Fernández, MD; Marchante-Serrano, C; Navarro-Quesada, FJ; Vaquero-Abellán, M, 1997) |
| "Oligomenorrhea occurred in 16 patients, polymenorrhea in 2." | 1.30 | Menstrual cycle and ovary alterations in women with epilepsy on antiepileptic therapy. ( Copello, F; Deagatone, C; Ferrari, E; Galimberti, CA; Gazzerro, E; Gianelli, MV; Magri, F; Manni, R; Murialdo, G; Polleri, A; Rollero, A; Sampaolo, P; Tartara, A, 1997) |
| "Epilepsy is a relatively common problem in children, adults and the elderly." | 1.30 | Treatment of the epileptic patient in the dental office. ( Haller, JS; Kennedy, BT, 1998) |
| " Reduction of VPA dosage and subsequent discontinuation 4 months later resulted in disappearance of clinical symptoms with a 20-point improvement at IQ testing and recovery of previous PM score." | 1.30 | Reversible pseudoatrophy of the brain and mental deterioration associated with valproate treatment. ( Belmonte, A; Canapicchi, R; Casalini, C; Guerrini, R; Perucca, E, 1998) |
| "A relationship between epilepsy and migraine has long been postulated, but the nature of this interaction is still debated." | 1.30 | Migraine with visual aura and photosensitive epileptic seizures. ( Bartolomei, F; Donnet, A, 1997) |
| " Patients received phenobarbitone as monotherapy or in combination with either of the antiepileptic drugs carbamazepine or valproic acid." | 1.30 | Detection of a drug-drug interaction on population-based phenobarbitone clearance using nonlinear mixed-effects modeling. ( Aoyama, T; Higuchi, S; Ohdo, S; To, H; Yukawa, E, 1998) |
| "The visual aura experiences reported in vague terms by some patients with RE may represent ictal dyslexia." | 1.30 | Reading epilepsy: report of five new cases and further considerations on the pathophysiology. ( Mayer, T; Reker, M; Wolf, P, 1998) |
| " We propose that individual dosage adjustment in VPA + CBZ polytherapy should be combined with monitoring of relevant enzyme activities in serum." | 1.30 | Valproate and carbamazepine comedication changes hepatic enzyme activities in sera of epileptic children. ( Cepelak, I; Lenicek, J; Mandusić, A; Rekić, B; Zanić Grubisić, T, 1998) |
| " In those patients who use these drugs at increased dosage levels or for long periods, the possibility of tubular dysfunction may be increased, and these dysfunctions may manifest in clinical symptoms." | 1.30 | N-acetyl-beta-glucosaminidase and beta-galactosidase activity in children receiving antiepileptic drugs. ( Cenani, A; Cengiz, M; Cengiz, S; Seven, M; Yüksel, A, 1999) |
| "Valproic acid (VPA)-induced encephalopathy is a rarely considered side effect, with somnolence, reduced motor activity and severe deterioration of cognitive and behavioural abilities." | 1.30 | [Encephalopathies caused by valproate]. ( Bräunig, P; Göbel, R; Görtzen, A, 1999) |
| "This report characterizes seizures in a novel genetic model of developmental epilepsy, the Flathead (FH) rat." | 1.30 | Characterization of seizures in the flathead rat: a new genetic model of epilepsy in early postnatal development. ( D'Mello, SR; LoTurco, JJ; Rattan, S; Sarkisian, MR, 1999) |
| "Felbamate (FBM) was initiated and VPA discontinued for improved seizure control." | 1.30 | Male infertility: possible association with valproate exposure. ( McCoy, GB; Yerby, MS, 1999) |
| " In both group A and group B patients, plasma ammonia levels were correlated with the valproic acid dosage (r = 0." | 1.30 | Carnitine deficiency and hyperammonemia in children receiving valproic acid with and without other anticonvulsant drugs. ( Chiarelli, F; Greco, R; Morgese, G; Verrotti, A, 1999) |
| "A 29-year-old female patient with Friedreich's ataxia and partial seizures with acute liver failure during VPA treatment is reported." | 1.30 | Fatal liver failure associated with valproate therapy in a patient with Friedreich's disease: review of valproate hepatotoxicity in adults. ( Hehlmann, R; Heubner, C; Holm, E; König, I; König, SA; Schenk, M; Sick, C; Weiss, A, 1999) |
| " Valproate, when the proper therapeutic dosage was belatedly realized, was seen as a superior treatment for generalized and partial epilepsies." | 1.30 | Clinical experience with new antiepileptic drugs: antiepileptic drugs in Europe. ( Loiseau, PJ, 1999) |
| "Rett's syndrome is a neurodevelopmental disorder which is caused by a mutation on the x-chromosome; thus, it only affects the female sex." | 1.30 | [Rett's syndrome: pathophysiology and anesthesiological implications]. ( Häuser, FM; Lennartz, H; Lukasewitz, P; Wichert, A, 1999) |
| "The medication regimens used to treat epilepsy are further complicated by the fact that most seizure medications are metabolized in the liver and have the potential for serious pharmacokinetic drug-drug interactions with many other medications." | 1.29 | Practical considerations in anticonvulsant therapy--Part 2. ( Cloyd, J; Garnett, WR; Holmes, GL; Meyer, MC; Schiffer, JR, 1995) |
| "One also had features of infantile autism." | 1.29 | Fetal valproate syndrome: clinical and neuro-developmental features in two sibling pairs. ( Chesler, N; Christianson, AL; Kromberg, JG, 1994) |
| "In this model, the threshold for seizures in rats is determined at short time intervals by applying ramp-shaped electrical pulse-trains directly to the cerebral cortex, allowing one to determine the time course of anti- or proconvulsant drug effects in individual rats." | 1.29 | Dose-dependent anticonvulsant and proconvulsant effects of nitric oxide synthase inhibitors on seizure threshold in a cortical stimulation model in rats. ( Gerecke, U; Koch, R; Löscher, W; Mevissen, M; Richter, A; Rundfeldt, C, 1995) |
| "Carbamazepine treatment resulted in prolongation of peak latencies of waves I-III-V and interpeak intervals I-III and I-V." | 1.29 | Effects of carbamazepine and valproate on brainstem auditory evoked potentials in epileptic children. ( Cenani, A; Dirican, A; Keskin, G; Senocak, D; Sozuer, D; Yalcin, E; Yuksel, A, 1995) |
| "Pancreatitis is usually considered a rare side effect of valproate." | 1.29 | Valproate-associated pancreatitis and cholecystitis in six mentally retarded adults. ( Buzan, RD; Dubovsky, SL; Firestone, D; Thomas, M, 1995) |
| "Trends in treatment of epilepsy in an institution for handicapped patients with epilepsy were investigated in a retrospective longitudinal study." | 1.29 | [Changes in drug therapy and in seizure frequency in an institution for epilepsy patients between 1971 and 1986]. ( May, T; Wohlhüter, M; Wolf, P, 1994) |
| " A review of published studies involving small numbers of elderly subjects or patients given phenytoin sodium, valproic acid, or carbamazepine demonstrates decreased protein binding and intrinsic clearance and increased half-life with advancing age." | 1.29 | Antiepileptics in the elderly. Pharmacoepidemiology and pharmacokinetics. ( Cloyd, JC; Lackner, TE; Leppik, IE, 1994) |
| " All these patients were receiving the usual dosage (1000 to 1500 mg per day) of Valproic acid (VPA)." | 1.29 | Impairment of consciousness induced by valproate treatment following neurosurgical operation. ( Baulac, M; de Billy, A; Durand, G; Landau, J; Philippon, J, 1993) |
| "A retrospective study of 113 patients treated with a sustained-release form of valproate (SRF-VPA), known as the "chrono" formulation in most European countries, led to the following conclusions: Patients treated with the old VPA formulation could immediately receive the same daily dosage of SRF-VPA without loss of seizure control when administered as a single evening dose." | 1.29 | A retrospective study of 113 epileptic patients treated with sustained-release valproate. ( Despland, PA, 1994) |
| "Valproic acid (VPA) may cause impaired platelet function, thrombocytopenia and, occasionally, severe bleeding." | 1.29 | Valproate-mediated disturbances of hemostasis: relationship to dose and plasma concentration. ( Collins, M; Gidal, B; Jones, J; Maly, M; Pitterle, M; Spencer, N; Williams, E, 1994) |
| "Valproic acid is a useful antiepileptic drug, with occasional gastrointestinal side effects." | 1.29 | [Hepatotoxicity induced by valproic acid in adults. Report of 3 cases]. ( Aguilera, L; Chesta, J; Galdames, D; Silva, C, 1993) |
| " In this context, anticonvulsant and neurotoxic pharmacodynamic interactions between phenytoin (PHT) and valproate (VPA) were assessed in an experimental model in mice." | 1.29 | Pharmacodynamic interactions between phenytoin and valproate: individual and combined antiepileptic and neurotoxic actions in mice. ( Bourgeois, BF; Chez, MG; Knowles, WD; Pippenger, CE, 1994) |
| " The frequency of withdrawal symptoms was significantly related to the dose of valproate given to the mothers in the third trimester, and there was a tendency for both the frequency of the minor abnormalities and the major malformations to be related to the valproate dosage in the first trimester." | 1.29 | Malformations, withdrawal manifestations, and hypoglycaemia after exposure to valproate in utero. ( Ebbesen, F; Thisted, E, 1993) |
| " VPA dosage was tapered and discontinued, with accompanying resolution of clinical, immunological and hematological signs of SLE 6 weeks after VPA discontinuation." | 1.29 | Valproate-induced systemic lupus erythematosus in a patient with partial trisomy of chromosome 9 and epilepsy. ( Diomedi, M; Gigli, GL; Grazia Pomponi, M; Masala, C; Pauri, F; Placidi, F; Scalise, A; Silvestri, G, 1996) |
| "Felbamate is a new antiepileptic drug (AED) with a good safety profile." | 1.29 | Weight loss in patients taking felbamate. ( Bergen, DC; Hoeppner, TJ; Kanner, A; Ristanovic, RK; Waicosky, K, 1995) |
| "Treatment with carbamazepine raised serum total cholesterol levels, C-HDL, phospholipid and A-I apoprotein in all groups, low density lipoproteins in females and B apoprotein males." | 1.29 | [The effects of phenobarbital, valproic acid and carbamazepine on the serum lipids and lipoproteins in a pediatric population]. ( Braga Hernández, S; Crespo Hernández, M; de Juan Frigola, J, 1996) |
| " A patient was only considered twice if his comedication or OCBZ dosage had been changed." | 1.29 | Fluctuations of 10-hydroxy-carbazepine during the day in epileptic patients. ( May, TW; Rambeck, B; Sälke-Kellermann, A, 1996) |
| " Routine clinical pharmacokinetic data (N = 1,010) collected from 466 patients receiving carbamazepine were analyzed according to a simple steady-state pharmacokinetic model with the use of NONMEM, a computer program designed for population pharmacokinetic analysis that allows pooling of data." | 1.29 | Detection of carbamazepine drug interaction by multiple peak approach screening using routine clinical pharmacokinetic data. ( Aoyama, T; Yukawa, E, 1996) |
| "6%) and without significant dose dependency, suggesting that this parameter may be useful for guiding VPA dosage adjustment and monitoring patient compliance." | 1.28 | Relationship between serum concentration and dose of valproic acid during monotherapy in adult outpatients. ( Oles, KS; Penry, JK; Tisdale, JE; Tsuyuki, RT, 1992) |
| "Chromosome fragility was sought in a well-defined cohort of patients with Lennox-Gastaut epilepsy syndrome." | 1.28 | Chromosome fragility in the Lennox-Gastaut epilepsy syndrome. ( Beran, RG; Smith, A, 1992) |
| "Cerebral cavernous angioma (cavernoma) has previously been treated by resection for all presentations when surgically resectable." | 1.28 | Cerebral cavernous angioma: a potentially benign condition? Successful treatment in 16 cases. ( Churchyard, A; Grainger, K; Khangure, M, 1992) |
| " Pharmacokinetic experiments with trans-2-en-VPA indicated non-linear kinetics with dose-dependent elimination rate and enterohepatic recirculation." | 1.28 | Pharmacokinetics, anticonvulsant efficacy, and adverse effects of trans-2-en-valproate after acute and chronic administration in amygdala-kindled rats. ( Hönack, D; Löscher, W; Rundfeldt, C, 1992) |
| " The pharmacokinetic parameters, necessary to define the pharmacokinetics of valproic acid, were calculated both after single dose: Cmax, tmax, kel, t1/2, Vd, AUC and Cl, and at steady state: Cminss Cmaxss and Fl%." | 1.28 | Single dose and steady state pharmacokinetics of valproic acid in adult epileptic patients. ( Lević, Z; Miljković, B; Pokrajac, M; Varagić, V, 1991) |
| "Free carnitine was low in tube-fed patients, as compared with that in oral-fed patients." | 1.28 | [The problems of valproate therapy in severely handicapped children--valproate induced hyperammonemia and hypocarnitinemia]. ( Iwamoto, H; Kobayashi, T; Matsui, K; Miyake, S; Ohtsuki, N; Yamada, M, 1991) |
| " They were divided into 3 groups treated with Mg-VPA in dosage of 800 mg, 600 mg and 400mg respectively at 7 pm in an attempt to find out an appropriate dosage with which the effective serum level could be maintained in the night time for those patients with only nocturnal seizures." | 1.28 | [Appropriate dosage for maintaining effective serum level at night after taking one dose of magnesium valproate with separate measurements of serum Mg++ concentration]. ( Yan, CS, 1991) |
| "Free plasma level/dose ratio of valproic acid (L/D-F) can be more effective than total plasma level/dose ratio (L/D-T) in adjusting dosage regimens." | 1.28 | Total and free valproic acid: plasma level/dose ratio in monotherapy. ( Abadín, JA; Durán, JA; Sánchez, A; Serrano, JS, 1991) |
| "Sister-chromatid exchange (SCE) and chromosome aberrations have been studied in peripheral lymphocytes of 20 epileptic children treated in monotherapy with valproic acid (VPA) for 6-52 months and in 2 matched control groups." | 1.28 | The effect of valproic acid on SCE and chromosome aberrations in epileptic children. ( Hu, LJ; Huang, YQ; Lu, BQ; Lu, XF, 1990) |
| " In order to define the minimal dosage of fentanyl required, the MD was titrated according to increases or decreases in the heart rate and/or mean arterial pressure exceeding 15 per cent of baseline ward values." | 1.28 | Anticonvulsant therapy increases fentanyl requirements during anaesthesia for craniotomy. ( Modica, PA; Spitznagel, EL; Tempelhoff, R, 1990) |
| " Eighty-four patients had been established on treatment with a single anticonvulsant drug (35 carbamazepine (CBZ), 30 sodium valproate (VPA), 19 phenytoin (PHT)) at unaltered dosage for the previous 3 months." | 1.28 | Cognitive function in adult epileptic patients established on anticonvulsant monotherapy. ( Brodie, MJ; Butler, E; Gillham, RA; Larkin, JG; Wiedmann, KD; Williams, N, 1990) |
| "Carbamazepine (CBMZP) has been implicated as an inhibitor of the activities of 5-aminolaevulinic acid dehydratase (ALA-D) and uroporphyrinogen I synthetase (URO-S)." | 1.28 | Protoporphyrinaemia and decreased activities of 5-aminolevulinic acid dehydrase and uroporphyrinogen I synthetase in erythrocytes of a Vitamin B6-deficient epileptic boy given valproic acid and carbamazepine. ( Carson, R; Haust, HL; Peter, F; Poon, HC; VanDeWetering, C, 1989) |
| "Phenytoin treatment may impair the validity of the caffeine liver function test." | 1.28 | Effect of phenytoin, carbamazepine, and valproic acid on caffeine metabolism. ( Büchsel, R; Kohl, D; Kreiten, K; Matern, S; Wietholtz, H; Zysset, T, 1989) |
| "There was a greater risk of recurrence among girls." | 1.28 | [Factors influencing the effectiveness of preventive treatment of febrile convulsions]. ( Armijo Simón, JA; Arteaga Manjón-Cabeza, R; Herranz Fernández, JL, 1989) |
| " Pharmacokinetic interactions between antiepileptic drugs may lead to considerable fluctuation in plasma drug concentration, and monotherapy is often preferable." | 1.27 | Pharmacokinetics of antiepileptic drugs. ( Neuvonen, PJ; Tokola, RA, 1983) |
| "From the analysis of 115 cases of primary generalized epilepsies treated for a mean duration of 43 months with sodium valproate as sole therapy, it appears that: the mean effective daily dosage is 21 mg/kg; the efficacy of valproate proved excellent in 82." | 1.27 | [Monotherapy with sodium valproate in generalized primary epilepsy. 2d phase: Study of long-term efficacy and tolerance]. ( Feuerstein, J; Revol, M; Roger, J; Sallou, C; Truelle, JL; Vercelletto, P; Weber, M, 1983) |
| " Serum level decline was biphasic in both instances with a terminal half-life of 27." | 1.27 | The effects of peritoneal dialysis on the single dose and steady state pharmacokinetics of valproic acid in a uremic epileptic child. ( Abbott, FS; Farrell, K; Ferguson, S; Godolphin, WJ; Orr, JM, 1983) |
| "We previously found that chronic administration of sodium valproate to suckling infant mice reduced plasma beta-hydroxybutyrate levels but had no effect on plasma free fatty acid or glycerol concentrations." | 1.27 | Chronic valproate administration reduces fasting ketonemia in children. ( Carroll, JE; Dodson, WE; Hauhart, RE; Tasch, V; Thurston, JH, 1983) |
| "Equivalent doses of enteric-coated divalproex were substituted for valproic acid in 15 epileptic patients who were on a three- or four-times-a-day dosing schedule." | 1.27 | Twice-daily dosing of valproate with divalproex. ( Hammond, EJ; Karas, BJ; Perchalski, RJ; Wilder, BJ, 1983) |
| "Phenytoin continues to be a very popular drug for most types of seizures, but carbamazepine, used adjunctively until recently, is effective as monotherapy for the control of partial seizures, particularly those of the complex partial variety." | 1.27 | Treatment of the nonconvulsive epilepsies. ( Dreifuss, FE, 1983) |
| "Only when the epilepsy is uncontrolled despite high plasma concentrations which cannot be raised because of side effects, a second drug should be given." | 1.27 | [Pharmacotherapy of epilepsy--current problems and controversies]. ( Schmidt, D, 1983) |
| "5 of these patients developed toxic encephalopathy with hyperammonemia induced by VPA." | 1.27 | Treatment of epileptic patients with valproic acid does not modify plasma and urine short-chain-fatty acids. ( Arnetoli, G; Boncinelli, L; Campostrini, R; Paganini, M; Zaccara, G; Zappoli, R, 1983) |
| " Pharmacokinetic parameters were equivalent for both preparations except for an absorption lag with the enteric-coated form." | 1.27 | Pharmacokinetics of enteric-coated valproic acid. ( Albright, PS; Bruni, J; Suria, D, 1984) |
| "Side effects of carbamazepine (CBZ), valproate (VPA) and clonazepam (CZP) are rare during long-term use but rather common and usually transient during the early phases of treatment." | 1.27 | Side effects of carbamazepine, valproate and clonazepam during long-term treatment of epilepsy. ( Keränen, T; Sivenius, J, 1983) |
| " However, whereas toxic reactions following phenytoin and carbamazepine are characterised by a rather short duration of exposure before symptoms occur with accompanying clinical features of hypersensitivity, valproate-induced hepatic toxicity exhibits no signs of hypersensitivity and often occurs following prolonged exposure, speaking in favor of a metabolic aberration as the underlying cause." | 1.27 | Hepatic toxicity of antiepileptic drugs: a review. ( Bentsen, KD; Gram, L, 1983) |
| " In 8 of them, a therapeutic dosage of VPA caused modifications of the state of consciousness ranging from coma to drowsiness and stupor." | 1.27 | Hyperammonemia and valproate-induced alterations of the state of consciousness. A report of 8 cases. ( Arnetoli, G; Campostrini, R; Moroni, F; Paganini, M; Zaccara, G; Zappoli, R, 1984) |
| " There were no significant differences between weight gainers and weight-stable patients with regard to age, sex, pretreatment overweight, duration of treatment, dosage or serum levels of valproate." | 1.27 | Weight gain during treatment with valproate. ( Andersen, T; Dam, M; Dinesen, H; Gram, L, 1984) |
| " Significant positive correlations were found between the dosage of CBZ, DPH, PMD and PB and both indices of enzyme induction." | 1.27 | A comparative study of the relative enzyme inducing properties of anticonvulsant drugs in epileptic patients. ( Hedges, A; Makki, KA; Perucca, E; Richens, A; Ruprah, M; Wilson, JF, 1984) |
| "Valproic acid (VPA) was given to 24 epileptic patients who were already being treated with other antiepileptic drugs." | 1.27 | Acute changes of blood ammonia may predict short-term adverse effects of valproic acid. ( Arnetoli, G; Baruzzi, A; Campostrini, R; Moroni, F; Paganini, M; Targioni, G; Valenza, T; Zaccara, G; Zappoli, R, 1984) |
| "Most electrically induced seizures involve forebrain structures, such as the amygdala or frontal cortex, but the following studies characterized a specific anatomic site in the inferior colliculus which generated seizure-like behavior after a single, low current electrical stimulation." | 1.27 | Electrically elicited seizures from the inferior colliculus: a potential site for the genesis of epilepsy? ( Breese, GR; Frye, GD; Greenwood, RS; McCown, TJ, 1984) |
| " Mean elimination half-life was 8." | 1.27 | Steady-state valproate pharmacokinetics during long term therapy. ( Eadie, MJ; Heazlewood, V; McKauge, L; Tyrer, JH, 1983) |
| "Free and total valproic acid (VPA) pharmacokinetic evaluation was carried out at steady state in six young epileptics who were also receiving other anticonvulsants." | 1.27 | Free valproic acid: steady-state pharmacokinetics in patients with intractable epilepsy. ( Budnik, D; Hall, K; Irvine-Meek, J; Leroux, M; Otten, N; Seshia, S, 1984) |
| "Carbamazepine was the most effective to block SEA at concentrations of 1-15 microM." | 1.27 | Effects of anticonvulsants on spontaneous epileptiform activity which develops in the absence of chemical synaptic transmission in hippocampal slices. ( Franceschetti, S; Hamon, B; Heinemann, U; Konnerth, A; Yaari, Y, 1985) |
| " They also indicate that chronic administration of sodium valproate, hence activation of central gamma-aminobutyric acid system, results in a blunting of the stimulated GH and ACTH secretion." | 1.27 | Neuroendocrine effects of chronic administration of sodium valproate in epileptic patients. ( Cavagnini, F; Danesi, L; Dubini, A; Invitti, C, 1988) |
| "The purpose of this study was to assess the effects of chronic administration of gradually increasing doses of the anti-petit mal agents, ethosuximide (15-60 mg/kg/day) and valproic acid (7." | 1.27 | Behavioral toxicity of chronic ethosuximide and sodium valproate treatment in the epileptic baboon, Papio papio. ( Killam, EK; Paule, MG, 1986) |
| " Twenty-three patients complained of various long-term adverse effects, while the other 17 remained symptom-free." | 1.27 | Long-term treatment with sodium valproate: monitoring of venous ammonia concentrations and adverse effects. ( Arnetoli, G; Campostrini, R; Messori, A; Paganini, M; Valenza, T; Zaccara, G; Zappoli, R, 1987) |
| "Carbamazepine, in contrast, has rather a stimulatory action." | 1.27 | [Modification of psychophysical performance of the human by anticonvulsants]. ( Meyer, FP; Walther, H, 1987) |
| " These results show that barbiturates should not be first-choice drugs in patients who have a chronic disease such as epilepsy, and indicate a schedule for barbiturate withdrawal which is safe and independent of hospitalization or monitoring of antiepileptic drug serum concentrations." | 1.27 | Barbiturate-refractory epilepsy: safe schedule for therapeutic substitution. ( Bittencourt, PR; Gorz, AM; Silvado, CE, 1986) |
| " Although rectal administration of sodium valproate (NaVPA) has been shown to be a possible alternative route, little is known about the bioavailability and local effects during repeated administration of NaVPA suppositories." | 1.27 | Bioavailability of sodium valproate suppositories during repeated administration at steady state in epileptic children. ( Bourgeois, BF; Issakainen, J, 1987) |
| "In particular, memory deficits, attentional problems, psychomotor slowing and reading and writing difficulties are highlighted, and the impact of the seizures, brain damage, and anticonvulsant drugs on cognitive function noted." | 1.27 | [Cognitive effects of antiepileptic drugs]. ( Trimble, R, 1987) |
| "Phenytoin levels were reduced to 37% of the original values, although the drug was given intravenously." | 1.27 | An interaction between cytostatic and anticonvulsant drugs. ( de Voogd-van der Straaten, I; Neef, C, 1988) |
| " The terminal half-life of free VPA (6." | 1.27 | Pharmacokinetics of free and total sodium valproate in adolescents and young adults during maintenance therapy. ( Herngren, L; Nergårdh, A, 1988) |
| " Children can begin to receive valproate treatment in a dosage of 20 to 30 mg/kg per day in two or three divided doses." | 1.27 | Valproate monotherapy in children. ( Murphy, JV, 1988) |
| " In each patient, the average unbound fraction for a dosing interval increased with increase in sodium valproate dose." | 1.27 | Changes in clearance of sodium valproate with changes in dose. ( Bury, RW; Fullinfaw, RO; Kilpatrick, CJ; Moulds, RF, 1987) |
| "01), and shorter half-life (9." | 1.27 | Comparison of steady-state pharmacokinetics of valproic acid in children between monotherapy and multiple antiepileptic drug treatment. ( Chiba, K; Hori, M; Iriki, T; Ishizaki, T; Naitoh, H; Shirai, Y; Suganuma, T, 1985) |
| " The mechanisms responsible for these effects have not been elucidated and possibly include decreased bioavailability or compliance, increased metabolic clearance, or decreased plasma protein binding." | 1.27 | Effects of pregnancy on antiepileptic drug utilization. ( Levy, RH; Yerby, MS, 1985) |
| "According to our convulsion intensity scoring system, these animals have an audiogenic response score (ARS) of 3 and the colony is designated the GEPR-3 colony." | 1.27 | Anticonvulsant drugs and the genetically epilepsy-prone rat. ( Dailey, JW; Jobe, PC, 1985) |
| "The % of gingival hyperplasia was significantly higher (P less than 0." | 1.27 | The effects of phenytoin and sodium valproate on the periodontal health of adult epileptic patients. ( Seymour, RA; Smith, DG; Turnbull, DN, 1985) |
| " Valproic acid elimination half-life increased from 7." | 1.27 | Valproic acid pharmacokinetics in children. II. Discontinuation of concomitant antiepileptic drug therapy. ( Cloyd, JC; Fischer, JH; Kriel, RL, 1985) |
| "Spina Bifida, Congenital Heart Defects, Clefts, Diaphragmatic Hernia and Trisomy 18 were more frequent than expected among babies with maternal epilepsy." | 1.27 | Maternal epilepsy and birth defects: a case-control study in the Italian Multicentric Registry of Birth Defects (IPIMC). ( Bertollini, R; Mastroiacovo, P; Segni, G, 1985) |
| " However, no adjustment of phenytoin dosage is warranted, unless clinically indicated, since the free phenytoin levels remain unchanged." | 1.26 | Interaction between phenytoin and valproate. ( Beran, RC; Sansom, LN; Schapel, GJ, 1980) |
| " VPA was excreted in the neonates with a mean half-life of 47 +/- 15 hr (n = 8) which is approximately 4 times the mean value found in adult epileptics." | 1.26 | Valproic acid and its metabolites: placental transfer, neonatal pharmacokinetics, transfer via mother's milk and clinical status in neonates of epileptic mothers. ( Häuser, I; Helge, H; Koch, S; Nau, H; Rating, D, 1981) |
| " These side-effects are dose-related, and the daily dosage should never exceed 40 mg/kg." | 1.26 | [Sodium valproate, platelet dysfunction and bleeding (author's transl)]. ( Loiseau, P, 1981) |
| "The Michaelis-Menten pharmacokinetics and bioavailability of phenytoin were evaluated in children." | 1.26 | Plasma levels and pharmacokinetics of antipileptic drugs in children. ( Miura, H, 1981) |
| "The diagnosis of functional seizures is difficult and emotional factors may be important in the cause and triggering of seizures." | 1.26 | Differentiating between organic and functional seizures: a common diagnostic problem. ( Chambers, BR; Vajda, FJ, 1981) |
| "Phenytoin (PHT) binding was also determined for comparison." | 1.26 | Diurnal oscillations in plasma protein binding of valproic acid. ( Levy, RH; Ojemann, LM; Patel, IH; Venkataramanan, R; Viswanathan, CT, 1982) |
| " Reducing the dosage by 19 mg/kg (A to B) decreased VPA plasma levels by 6." | 1.26 | Monitoring free valproic acid in epilepsy patients medicated with coanticonvulsants. ( Haidukewych, D; Rodin, EA, 1982) |
| "A Consensus Development Conference on Febrile Seizures was held at the National Institutes of Health in USA in May 1980." | 1.26 | ["Fever convulsions" in children. Current viewpoints on diagnosis, therapy and prognosis]. ( Helwig, H; Staudt, F, 1982) |
| "Results of clinical and pharmacokinetic observations on sodium valproate (VPA) are reported from a long-term study in 100 children with epilepsy." | 1.26 | Clinical and pharmacokinetic observations on sodium valproate - a 5-year follow-up study in 100 children with epilepsy. ( Henriksen, O; Johannessen, SI, 1982) |
| "Sixty-five children with seizure disorders, who had been treated with multiple anticonvulsants but were poorly controlled, were selected from the Montreal Children's Hospital Convulsive Disorder Clinic and Neurology Service and were treated with sodium valproate (valproate)." | 1.26 | Sodium valproate in the treatment of the intractable childhood epileptic. ( Keene, DL; Metrakos, K; Sherwin, A; Watters, GV, 1982) |
| "1 The fluctuations in protein binding of sodium valproate during one dosing interval were studied in five patients stabilized on valproate and taking concurrent anticonvulsant therapy." | 1.26 | Intra-dose variation in plasma protein binding of sodium valproate in epileptic patients. ( Kilpatrick, CJ; Marty, JJ; Moulds, RF, 1982) |
| "Only 21% of those with myoclonic astatic epilepsy have become free from seizures." | 1.26 | Sodium valproate: monotherapy and polytherapy. ( Covanis, A; Gupta, AK; Jeavons, PM, 1982) |
| "Since epilepsy is a long-standing condition lasting for years to decades, short-spanned cross-sectional observations are often misleading." | 1.26 | Therapeutic concentration of antiepileptic drugs and the severity of epileptogenesis. ( Kakegawa, N; Seino, M, 1982) |
| "7 cases of stuporous states or coma induced in epileptic subjects by the rapid administration of high doses of sodium valproate are described." | 1.26 | Stuporous states or coma induced by the rapid administration of high doses of sodium valproate. ( Gastaut, H; Iemolo, F, 1982) |
| " The bioavailability appeared to be the same for all the forms." | 1.26 | Comparison of the effectiveness of several formulations of sodium valproate: tablets, enteric-coated capsules, solutions and rectal capsules. ( Avanzini, G; Battino, D; Biraghi, M; Cusi, C; Nespolo, A, 1982) |
| " The drug was absorbed and excreted rapidly; the mean half-life was 9." | 1.26 | Sodium valproate: pharmacokinetics and effectivensss in treating intractable seizures. ( Dreifuss, FE; Kupferberg, HJ; Penry, JK; Redenbaugh, JE; Sato, S, 1980) |
| " The following results were found while DPA was administered in a relatively high dosage with a mean of 48 mg/kg body weight/day and ranging from 7 to 125 mg/kg/day." | 1.26 | Treatment of childhood epilepsy with dipropylacetic acid (DPA). ( Blaschke, E; Fehr, R; Lagenstein, I; Rothe, M; Sternowsky, HJ, 1978) |
| " A twice daily dosage regime was satisfactory." | 1.26 | Sodium valproate (Epilim) in epilepsy: a trial. ( Briant, RH; Foote, SE; Wallis, WE, 1978) |
| "Valproic acid is a new antiepileptic drug recently introduced in the United States for the treatment of absence seizures." | 1.26 | Clinical efficacy of valproic acid in relation to plasma levels. ( Bruni, J; Crawford, LE; Thomas, M; Villarreal, HJ; Wilder, BJ; Willmore, LJ, 1978) |
| " DPA was eliminated with a half-life of 7." | 1.26 | Pharmacokinetic studies with valproic acid in man. ( Klotz, U, 1977) |
| "Valproic acid assay was performed by gas-liquid chromatography." | 1.26 | Steady-state kinetics of valproic acid in epileptic patients. ( Bruni, J; Perchalski, RJ; Villarreal, HJ; Wilder, BJ; Willmore, LJ, 1978) |
| " 4) Dosage and plasma levels did not appear to show a close correlation." | 1.26 | Plasma sodium valproate levels and clinical response in epilepsy. ( Anthony, M; Hinterberger, H; Lance, JW, 1977) |
| "Carbamazepine has recently been introduced for the treatment of generalized tonic-clonic and partial seizures." | 1.26 | Recent advances in drug therapy for epilepsy. ( Bruni, J, 1979) |
| " The abnormal values returned promptly to normal when the drug therapy was discontinued or the dosage reduced." | 1.26 | A direct hepatotoxic effect of valproic acid. ( McLain, LW; Sussman, NM, 1979) |
| "Hyperglycinemia was induced by dipropylacetate (DPA) (dose 14-41 mg/kg per day) in 10 Finnish epileptic patients with neurologically disabling diseases of various kinds." | 1.26 | Dipropylacetate and hyperglycinemia. ( Huhtaniemi, I; Linna, SL; Saukkonen, AL; Similä, S; von Wendt, L, 1979) |
| " The results indicate that a proportional rise in plasma sodium valproate levels can be expected following dosage increments in an individual patient." | 1.26 | Sodium valproate: dose-plasma level relationships and interdose fluctuations. ( Bladin, PF; Mihaly, GW; Miles, JL; Morris, PM; Vajda, FJ, 1978) |
| " Dosage varied from 23 to 54mg/kg and twice-daily administration was usual." | 1.26 | Treatment of generalized epilepsies of childhood and adolescence with sodium valproate ("epilim"). ( Clark, JE; Jeavons, PM; Maheshwari, MC, 1977) |
| "79 patients with primary generalized epilepsies have been treated with DPA in a medium dosage of 51 mg/kg bodyweight/day, range 14 to 125 mg/kg/day, for a medium time of 22 months, range 2 to 49 months." | 1.26 | [The treatment of primary generalized epilepsies with dipropyl acetate (DPA)]. ( Blaschke-Zimmermann, E; Fehr, R; Iffland, E; Lagenstein, I; Sternowsky, HJ, 1977) |
| " In rather short time reliable information concerning indication, compatibility and dosage can be received." | 1.26 | [Austrian complex-study on dipropylacetate. Pediatric experiences]. ( Groh, Ch; Rosenmayr, FW, 1976) |
Research
Studies (2,662)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 593 (22.28) | 18.7374 |
| 1990's | 447 (16.79) | 18.2507 |
| 2000's | 664 (24.94) | 29.6817 |
| 2010's | 666 (25.02) | 24.3611 |
| 2020's | 292 (10.97) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Conley, JD | 1 |
| Kohn, H | 1 |
| Flaherty, PT | 1 |
| Greenwood, TD | 1 |
| Manheim, AL | 1 |
| Wolfe, JF | 1 |
| Pessah, N | 2 |
| Bialer, M | 15 |
| Wlodarczyk, B | 2 |
| Finnell, RH | 2 |
| Yagen, B | 6 |
| Azam, F | 1 |
| El-Gnidi, BA | 1 |
| Alkskas, IA | 1 |
| McComsey, DF | 1 |
| Smith-Swintosky, VL | 1 |
| Parker, MH | 1 |
| Brenneman, DE | 1 |
| Malatynska, E | 1 |
| White, HS | 3 |
| Klein, BD | 1 |
| Wilcox, KS | 1 |
| Milewski, ME | 1 |
| Herb, M | 1 |
| Finley, MF | 1 |
| Liu, Y | 3 |
| Lubin, ML | 1 |
| Qin, N | 1 |
| Reitz, AB | 1 |
| Maryanoff, BE | 2 |
| Kumari, S | 2 |
| Mishra, CB | 1 |
| Tiwari, M | 1 |
| Chen, L | 5 |
| Xu, Z | 2 |
| Huang, H | 1 |
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| Tomlinson, EB | 1 |
Clinical Trials (35)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 2, Double-blind, Randomized, Placebo-controlled Pharmacokinetic Trial in 2 Parallel Groups to Investigate Possible Drug-drug Interactions Between Stiripentol or Valproate and GWP42003-P in Patients With Epilepsy[NCT02607891] | Phase 2 | 35 participants (Actual) | Interventional | 2016-11-09 | Completed | ||
| PSG in Valproate-induced Nocturnal Enuresis in Children[NCT04191863] | 260 participants (Actual) | Observational | 2018-09-01 | Completed | |||
| Exploration of Genotype Based Personalized Prescription of Valproate Sodium in Anti-epileptic Treatment[NCT01172626] | 150 participants (Anticipated) | Observational | 2010-08-31 | Not yet recruiting | |||
| The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy[NCT05450822] | 550 participants (Anticipated) | Observational | 2022-02-18 | Recruiting | |||
| A Therapeutic Confirmatory, Open-label, Multi-center, Randomized 2 Parallel Groups, Community-based Trial Studying the Efficacy and Safety of Levetiracetam (1000 to 3000 mg/Day Oral Tablets 250-500 mg b.i.d.) Compared to Sodium Valproate (1000 to 2000 mg/[NCT00175903] | Phase 3 | 1,701 participants (Actual) | Interventional | 2005-02-28 | Completed | ||
| Comparative Study of Dietary and Immunological Management of Refractory Epilepsy in Children Attending Assiut Pediatric University Hospital[NCT04542629] | Phase 4 | 140 participants (Anticipated) | Interventional | 2020-10-01 | Not yet recruiting | ||
| EEG Objectification in Neuropsychiatry[NCT01476228] | 100 participants (Anticipated) | Interventional | 2011-11-30 | Not yet recruiting | |||
| Evaluation of Valproic Acid (VPA) as Adjunctive Therapy for Liver Transplant Patients With Moderate to Severe Hemorrhage at Risk of Ischemia Reperfusion (I/R) Injury[NCT04531592] | Phase 2 | 0 participants (Actual) | Interventional | 2022-01-31 | Withdrawn (stopped due to Study terminated by the Sponsor) | ||
| Phase I Study of Cytolytic Viral Activation Therapy (CVAT) for Recurrent/Metastatic Nasopharyngeal Carcinoma[NCT02761291] | Phase 1 | 18 participants (Anticipated) | Interventional | 2016-05-31 | Recruiting | ||
| Evaluation of Valproic Acid (VPA) as Adjunctive Therapy for Trauma Patients With Moderate to Severe Hemorrhage at Risk of Ischemia Reperfusion (I/R) Injury[NCT04531579] | Phase 2 | 0 participants (Actual) | Interventional | 2022-01-31 | Withdrawn (stopped due to Study terminated by the Sponsor.) | ||
| Effect of Iron Status on Occurrence of Non-transferrin-bound Iron (NTBI) in Serum in Response to an Oral Iron Load[NCT02831712] | 50 participants (Anticipated) | Interventional | 2013-04-30 | Active, not recruiting | |||
| A Clinical Pharmacokinetics Comparing Brand and Generic Topiramate in Epilepsy Patients : A Open-label,Randomised, Three-period Crossover Study[NCT02113787] | 24 participants (Actual) | Interventional | 2014-02-28 | Completed | |||
| Pilot Study of Seizure Prophylaxis With Levetiracetam in Aneurysmal Subarachnoid Hemorrhage[NCT01935908] | Phase 4 | 0 participants (Actual) | Interventional | 2013-05-31 | Withdrawn (stopped due to no funding) | ||
| Levetiracetam, Carbamazepine and Lamotrigine and Hormonal Side Effects in Adult Males and Females.[NCT00460070] | 240 participants (Actual) | Observational | 2007-01-31 | Completed | |||
| Effects and Consequences for Mother and Child From Treatment for Depression, A Prospective Randomized, Placebo- Controlled, Trial With Internet-based Cognitive Behavior Therapy and Sertraline or Placebo for Moderate Depression in Pregnancy[NCT02185547] | Phase 4 | 17 participants (Actual) | Interventional | 2016-02-21 | Terminated (stopped due to Difficulties in recruiting participants.) | ||
| TOPAMAX (Topiramate) Monotherapy Comparison Trial to Standard Monotherapy in the Treatment of Newly Diagnosed Epilepsy (RWJ-17021-000); Phase IIIB[NCT00236717] | Phase 3 | 865 participants (Actual) | Interventional | 1997-09-30 | Completed | ||
| Effect of Melatonin on Seizure Outcome, Neuronal Damage and Quality of Life in Patients With Generalized Epilepsy: A Randomized, add-on Placebo-controlled Clinical Trial[NCT03590197] | Phase 4 | 104 participants (Actual) | Interventional | 2018-08-06 | Completed | ||
| Evaluation d'un Dispositif de Suivi téléphonique Sur la Qualité de Vie Dans Les Crises Psychogènes Non Epileptiques.[NCT02311829] | 136 participants (Anticipated) | Interventional | 2014-01-31 | Recruiting | |||
| A Pilot Study of Prophylactic Management of Lamotrigine for Bipolar Disorder in Pregnant Women[NCT03774641] | 20 participants (Anticipated) | Observational | 2018-12-03 | Recruiting | |||
| Effect of the Treatment of Vitamin D Deficiency in Drug-resistant Epilepsy[NCT03475225] | Phase 3 | 400 participants (Anticipated) | Interventional | 2018-04-30 | Not yet recruiting | ||
| A Multicenter, Open-Label Conversion of Valproate Monotherapy to Lamotrigine Monotherapy in Patients With Epilepsy[NCT00043914] | Phase 4 | 72 participants | Interventional | 2002-01-14 | Completed | ||
| A Phase II Multiple Site, Randomized, Placebo-Controlled Trial of Oral Valproic Acid for Autosomal Dominant Retinitis Pigmentosa[NCT01233609] | Phase 2 | 90 participants (Actual) | Interventional | 2010-11-30 | Completed | ||
| A Study of Divalproex Sodium in Children With Autism Spectrum Disorder and Epileptiform EEG[NCT01170325] | Phase 2 | 0 participants (Actual) | Interventional | 2010-06-30 | Withdrawn | ||
| Bioequivalence Study of Sodium Valproate and Valproic Acid Extended Release Tablets in Healthy Human Volunteers[NCT05641649] | Phase 4 | 16 participants (Anticipated) | Interventional | 2023-08-06 | Active, not recruiting | ||
| Efficacy, Tolerability and Adherence of the Modified Atkins Diet on Drug-resistant Epilepsy in Adults Patients[NCT03183076] | 14 participants (Actual) | Interventional | 2015-09-01 | Completed | |||
| Effect of Adding Lamotrigine to Sodium Valproate in Childhood Epilepsy: Clinicolabratory Study[NCT05881928] | Phase 4 | 50 participants (Anticipated) | Interventional | 2023-07-25 | Not yet recruiting | ||
| Estudio clínico Fase III Para Evaluar la Eficacia terapéutica en Pacientes Mexicanos Con Dislipidemia Mediante el Uso vía Oral de L-Carnitina + Atorvastatina Comparado Con Atorvastatina[NCT03696940] | Phase 3 | 120 participants (Actual) | Interventional | 2018-05-28 | Active, not recruiting | ||
| A Prospective Study on Long-term Outcome and Potential Usefulness fo an Intervention Aimed at Reducing Adverse Effects in Patients With Refractory Epilepsy[NCT03939507] | 1,000 participants (Actual) | Interventional | 2006-11-06 | Completed | |||
| Reducing Cardiovascular Risk in Adults With Serious Mental Illness Using an Electronic Medical Record-based Clinical Decision Support[NCT02451670] | 10,347 participants (Actual) | Interventional | 2016-01-20 | Completed | |||
| Evaluating the Impact of Supplementing Residential Substance Use Treatment With Written Exposure Therapy for Veterans With Co-Occurring PTSD and Substance Use Disorders[NCT05536908] | 50 participants (Anticipated) | Interventional | 2023-06-22 | Recruiting | |||
| Combined Scalp and Ear Acupuncture in Patients With Proton Pump Inhibitor- Dependent Gastroesophageal Reflux Disease[NCT04660019] | 43 participants (Actual) | Interventional | 2020-08-10 | Completed | |||
| In Vivo Study of Safety, Tolerability and Dosing Effect on SMN mRNA and Protein Levels of Valproic Acid in Patients With Spinal Muscular Atrophy[NCT00374075] | Phase 1 | 42 participants | Interventional | 2003-09-30 | Completed | ||
| Phase I/II Trial of Valproic Acid and Carnitine in Infants With Spinal Muscular Atrophy Type I (CARNI-VAL Type I)[NCT00661453] | Phase 1/Phase 2 | 40 participants (Actual) | Interventional | 2008-04-30 | Completed | ||
| Multi-center Phase II Trial of Valproic Acid and Carnitine in Patients With Spinal Muscular Atrophy (SMA CARNI-VAL Trial)[NCT00227266] | Phase 2 | 94 participants (Actual) | Interventional | 2005-09-30 | Completed | ||
| Valproic Acid-associated Hypoalbuminemia in Medically Fragile Pediatric and Young Adult Patients in a Long Term Care Facility Part 1: Potential Mechanism for Decreased Albumin Synthesis[NCT00723762] | 90 participants (Anticipated) | Observational | 2009-02-28 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
Mean Change From Baseline in Best Corrected Visual Acuity
Mean change in best corrected visual acuity as assessed by ETDRS (Early Treatment Diabetic Retinopathy Study) method from baseline to week 52 (NCT01233609)
Timeframe: baseline to week 52
| Intervention | letters read correctly (Mean) |
|---|---|
| Valproic Acid -- Right Eye | -1.4 |
| Valproic Acid--Left Eye | 0.0 |
| Placebo --Right Eye | 0.2 |
| Placebo --Left Eye | 1.3 |
Mean Change in Visual Field Area From Baseline to 52 Weeks--I4e Isopter
Mean change in visual field area from baseline to 52 weeks. Visual field area is measured with semi-automated kinetic perimetry (SKP) using the Octopus 900 (Haag-Streit) with the I4e target size for each eye and done at least twice to ensure reliable sessions; the visual field area measurements are averaged over the two sessions. Analysis performed with linear mixed model (NCT01233609)
Timeframe: baseline to week 52
| Intervention | Visual field area (degrees squared) (Mean) |
|---|---|
| Placebo--Right Eye | 80.9 |
| Placebo--Left Eye | 115.7 |
| Valproic Acid--Right Eye | 5.3 |
| Valproic Acid--Left Eye | 19.5 |
Mean Change in Visual Field Area From Baseline to 52 Weeks--III4e Isopter
Mean change in visual field area from baseline to 52 weeks. Visual field area is measured with semi-automated kinetic perimetry (SKP) using the Octopus 900 (Haag-Streit) with the III4e target size for each eye and done at least twice to ensure reliable sessions; the visual field area measurements are averaged over the two sessions. Analysis performed with linear mixed model (NCT01233609)
Timeframe: baseline to week 52
| Intervention | Visual field area (degrees squared) (Mean) |
|---|---|
| Placebo--Right Eye | -122.9 |
| Placebo--Left Eye | -112.0 |
| Valproic Acid--Right Eye | -293.7 |
| Valproic Acid--Left Eye | -237.1 |
Static Perimetry by Treatment Arm--Full Field Hill of Vision
Mean change from baseline at week 52 for Full field Hill of Vision (Static perimetry) (NCT01233609)
Timeframe: baseline to week 52
| Intervention | db-steridians (Mean) |
|---|---|
| Placebo--Right Eye | -0.3 |
| Placebo--Left Eye | -1.4 |
| Valproic Acid--Right Eye | -0.2 |
| Valproic Acid--Left Eye | -0.6 |
Static Perimetry Volume--30 Degree Hill of Vision
Mean Change from baseline to week 52 for Static Perimetry Volume --30 Degree Hill of Vision. Full field static perimetry protocol was followed using the Octopus 900 (Haag-Streit) for a single session for each eye. (NCT01233609)
Timeframe: baseline to week 52
| Intervention | db-steridans (Mean) |
|---|---|
| Placebo--Right Eye | -0.3 |
| Placebo--Left Eye | -0.3 |
| Valproic Acid--Right Eye | -0.2 |
| Valproic Acid--Left Eye | -0.2 |
Predicted Annual Rate of Change in 10 Year Risk of Fatal or Nonfatal Heart Attack or Stroke
A modifiable risk component for each cardiovascular risk factor not at optimal goal at the time of each encounter was calculated as the difference between total 10-year atherosclerotic cardiovascular disease risk with the patient's actual values and the goal value. Total modifiable cardiovascular risk was calculated by summing the modifiable cardiovascula risk components across cardiovascular risk factors not at optimal goal at the time of the encounter, and was calculated for each enrolled patient at the index visit and each subsequent encounter during the intervention period. Annual rate of change in modifiable cardiovascular risk was estimated from all patient encounters. A comparison of the difference in model-estimated rate of change in modifiable cardiovascular risk at 12 months post-index tested the primary efficacy hypothesis. (NCT02451670)
Timeframe: Index to 12 months post index visit
| Intervention | percentage of annual rate of change (Number) |
|---|---|
| Prioritized Clinical Decision Support | 14.2 |
| Usual Care | 20.8 |
Anthropometric Measures of Nutritional Status (Body Mass Index [BMI] Z-scores, Weight for Length Ratios, Lean/Fat Mass Via DEXA, Growth Parameters, and Triceps Skinfold Measures)
(NCT00661453)
Timeframe: -2 weeks, time 0, 3 months, 6 months
| Intervention | g (Mean) | |||||
|---|---|---|---|---|---|---|
| Lean Mass Baseline | Lean Mass 3 months | Lean Mass 6 months | Fat Mass Baseline | Fat Mass 3 months | Fat Mass 6 months | |
| SMA Type 1 | 4317.15 | 4993.92 | 5133.83 | 3011.37 | 3618.25 | 4316.08 |
Max CMAP Amplitude (Mean)
The maximum Compound Motor Action Potential (CMAP) is a measurement obtained through EMG testing that is associated with disease progression. In this study, we measure the maximum CMAP by stimulating one nerve in the hand and measuring the response of the muscle. This is done multiple times, the outcome used is the highest peak, or response observed. (NCT00227266)
Timeframe: 1 month prior to official enrollment, beginning of study (0 months), 6 months, 12 months (data point not available)
| Intervention | mV (Mean) | |
|---|---|---|
| Baseline | 6 months | |
| Cohort 1a Sitters Placebo Then Treatment | 2.28 | 2.32 |
| Cohort 1b Sitters Treatment | 2.93 | 2.37 |
| Cohort 2 Standers and Walkers - Treatment | 5.52 | 6.56 |
Max CMAP Amplitude Median
The maximum Compound Motor Action Potential (CMAP) is a measurement obtained through EMG testing that is associated with disease progression. In this study, we measure the maximum CMAP by stimulating one nerve in the hand and measuring the response of the muscle. This is done multiple times, the outcome used is the highest peak, or response observed. (NCT00227266)
Timeframe: 1 month prior to official enrollment, beginning of study (0 months), 6 months, 12 months (data point not available)
| Intervention | mV (Median) | |
|---|---|---|
| Baseline | 6 months | |
| Cohort 1a Sitters Placebo Then Treatment | 1.91 | 1.44 |
| Cohort 1b Sitters Treatment | 2.2 | 1.8 |
| Cohort 2 Standers and Walkers - Treatment | 5.3 | 5.85 |
Max CMAP Area (Mean)
The maximum Compound Motor Action Potential (CMAP) area is a measurement obtained through EMG testing that is associated with disease progression. In this study, we measure the maximum CMAP by stimulating one nerve in the hand and measuring the response of the muscle. This procedure is repeated multiple times. The maximum area is the response that results in the largest area under the response curve. (NCT00227266)
Timeframe: 1 month prior to official enrollment, beginning of study (0 months), 6 months, 12 months (data point not available)
| Intervention | mVms (Mean) | |
|---|---|---|
| Baseline | 6 months | |
| Cohort 1a Sitters Placebo Then Treatment | 5.46 | 5.28 |
| Cohort 1b Sitters Treatment | 5.45 | 5.26 |
| Cohort 2 Standers and Walkers - Treatment | 14.85 | 16.26 |
Max CMAP Area (Median)
The maximum Compound Motor Action Potential (CMAP) area is a measurement obtained through EMG testing that is associated with disease progression. In this study, we measure the maximum CMAP by stimulating one nerve in the hand and measuring the response of the muscle. This procedure is repeated multiple times. The maximum area is the response that results in the largest area under the response curve. (NCT00227266)
Timeframe: 1 month prior to official enrollment, beginning of study (0 months), 6 months, 12 months (data point not available)
| Intervention | mVms (Median) | |
|---|---|---|
| Baseline | 6 months | |
| Cohort 1a Sitters Placebo Then Treatment | 3.6 | 3.74 |
| Cohort 1b Sitters Treatment | 4.6 | 3.4 |
| Cohort 2 Standers and Walkers - Treatment | 13.65 | 16.85 |
Modified Hammersmith Change From Baseline to 6 Months
Comparison of Modified Hammersmith Change from baseline to 6 months. Scores range from 0 to 40. A higher score indicates a better outcome. This scale is used to assess gross motor abilities of non-ambulant children with SMA in multiple research trials as well as in clinical settings. (NCT00227266)
Timeframe: 0 months, 6 months
| Intervention | Score (Mean) | ||
|---|---|---|---|
| Baseline visit (0 weeks) | 6 Month visit (V2) | Change from Baseline | |
| Cohort 1a Sitters Placebo Then Treatment | 20.0 | 20.6 | 0.6 |
| Cohort 1b Sitters Treatment | 16.6 | 16.8 | 0.2 |
Modified Hammersmith Extend Baseline
"Baseline Modified Hammersmith Extend testing. The baseline test is the score they receive during their screening visits. This scale ranges from 0 to 56. A higher score indicates a better outcome.~This scale is used to assess gross motor abilities of children with SMA in multiple research trials as well as in clinical settings." (NCT00227266)
Timeframe: 1 month prior to enrollment, at enrollment (0 months)
| Intervention | Score (Mean) | |
|---|---|---|
| Modified Hammersmith Extend at S1 (-4 weeks) | Modified Hammersmith Extend at S2 (0 weeks) | |
| Cohort 2 Experimental | 47.0 | 48.3 |
Reviews
317 reviews available for valproic acid and Aura
| Article | Year |
|---|---|
Treatment of valproic acid overdose with meropenem in an epileptic patient.
Topics: Adult; Anti-Bacterial Agents; Anticonvulsants; Carbapenems; Drug Overdose; Epilepsy; Female; Humans; | 2022 |
Antiseizure medications and thyroid hormone homeostasis: Literature review and practical recommendations.
Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Cross-Sectional Studies; Epilepsy; Female; Homeosta | 2022 |
Is the prevalence of thyroid disease higher in children receiving antiepileptic medication? A systematic review and meta-analysis.
Topics: Anticonvulsants; Carbamazepine; Child; Epilepsy; Humans; Levetiracetam; Prevalence; Thyroid Diseases | 2022 |
Combined effects of levetiracetam and sodium valproate on paediatric patients with epilepsy: a systematic review and meta-analysis.
Topics: Anticonvulsants; Child; Epilepsy; Humans; Levetiracetam; Topiramate; Valproic Acid | 2022 |
Insights into Structural Modifications of Valproic Acid and Their Pharmacological Profile.
Topics: Amides; Animals; Anticonvulsants; Drug Monitoring; Epilepsy; Humans; Molecular Structure; Structure- | 2021 |
The efficacy of lamotrigine after failure of the first administration of valproate in treating epilepsy: a systematic review and meta-analysis.
Topics: Epilepsy; Humans; Lamotrigine; Quality of Life; Triazines; Valproic Acid | 2022 |
Epilepsy in Pregnancy-Management Principles and Focus on Valproate.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Autism | 2022 |
Fanconi Syndrome Secondary to Sodium Valproate Therapy: Experience and Literature Review.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Fanconi Syndrome; Female; Humans; Ma | 2022 |
Published population pharmacokinetic models of valproic acid in adult patients: a systematic review and external validation in a Chinese sample of inpatients with bipolar disorder.
Topics: Adult; Anticonvulsants; Bayes Theorem; Bipolar Disorder; Child; China; Epilepsy; Humans; Inpatients; | 2022 |
Transcriptome meta-analysis of valproic acid exposure in human embryonic stem cells.
Topics: Anticonvulsants; Epilepsy; Female; Human Embryonic Stem Cells; Humans; Pregnancy; Transcriptome; Val | 2022 |
Side effects of long-term oral anti-seizure drugs on thyroid hormones in patients with epilepsy: a systematic review and network meta-analysis.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Lamotrigine; Levetiracetam; Network Meta-Analysis; | 2022 |
Effect of long-term valproic acid therapy on lipid profiles in paediatric patients with epilepsy: a meta-analysis
Topics: Child; Cholesterol, HDL; Cholesterol, LDL; Epilepsy; Humans; Lipids; Valproic Acid | 2022 |
Management of epilepsy in brain tumor patients.
Topics: Anticonvulsants; Benzodiazepines; Brain Neoplasms; Epilepsy; Humans; Isocitrate Dehydrogenase; Lacos | 2022 |
The interplay of epilepsy with impaired mitophagy and autophagy linked dementia (MAD): A review of therapeutic approaches.
Topics: Anticonvulsants; Carbamazepine; Dementia; Epilepsy; Felbamate; Gabapentin; Humans; Inflammasomes; La | 2022 |
Risk factors and outcome of hyperammonaemia in people with epilepsy.
Topics: Adult; Ammonia; Epilepsy; Humans; Hyperammonemia; Observational Studies as Topic; Oxcarbazepine; Ris | 2022 |
Therapeutic approach to neurological manifestations of Angelman syndrome.
Topics: Angelman Syndrome; Anticonvulsants; Epilepsy; Epilepsy, Generalized; Humans; Valproic Acid | 2022 |
Breastfeeding while on treatment with antiseizure medications: a systematic review from the ILAE Women Task Force
Topics: Breast Feeding; Cannabidiol; Carbamazepine; Child; Clobazam; Clonazepam; Epilepsy; Ethosuximide; Eve | 2022 |
[Paediatric status epilepticus].
Topics: Adult; Anesthetics; Anticonvulsants; Benzodiazepines; Child; Epilepsy; Humans; Ketamine; Lacosamide; | 2022 |
Effects of Maternal Use of Antiseizure Medications on Child Development.
Topics: Anticonvulsants; Child; Child Development; Epilepsy; Female; Folic Acid; Humans; Pregnancy; Pregnanc | 2022 |
Refractory Convulsive Status Epilepticus Provoked by Intoxication with Dalfampridine in a Patient with Multiple Sclerosis and Depression Disorder: A Case Report and Literature Review.
Topics: 4-Aminopyridine; Adult; Epilepsy; Humans; Multiple Sclerosis; Sodium; Status Epilepticus; Valproic A | 2023 |
Refractory Convulsive Status Epilepticus Provoked by Intoxication with Dalfampridine in a Patient with Multiple Sclerosis and Depression Disorder: A Case Report and Literature Review.
Topics: 4-Aminopyridine; Adult; Epilepsy; Humans; Multiple Sclerosis; Sodium; Status Epilepticus; Valproic A | 2023 |
Refractory Convulsive Status Epilepticus Provoked by Intoxication with Dalfampridine in a Patient with Multiple Sclerosis and Depression Disorder: A Case Report and Literature Review.
Topics: 4-Aminopyridine; Adult; Epilepsy; Humans; Multiple Sclerosis; Sodium; Status Epilepticus; Valproic A | 2023 |
Refractory Convulsive Status Epilepticus Provoked by Intoxication with Dalfampridine in a Patient with Multiple Sclerosis and Depression Disorder: A Case Report and Literature Review.
Topics: 4-Aminopyridine; Adult; Epilepsy; Humans; Multiple Sclerosis; Sodium; Status Epilepticus; Valproic A | 2023 |
Valproate, divalproex, valpromide: Are the differences in indications justified?
Topics: Bipolar Disorder; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Humans; Valproic Acid | 2023 |
Valproate, divalproex, valpromide: Are the differences in indications justified?
Topics: Bipolar Disorder; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Humans; Valproic Acid | 2023 |
Valproate, divalproex, valpromide: Are the differences in indications justified?
Topics: Bipolar Disorder; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Humans; Valproic Acid | 2023 |
Valproate, divalproex, valpromide: Are the differences in indications justified?
Topics: Bipolar Disorder; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Humans; Valproic Acid | 2023 |
Kidney tubular injury induced by valproic acid: systematic literature review.
Topics: Epilepsy; Humans; Kidney; Kidney Tubules, Proximal; Proteinuria; Valproic Acid | 2023 |
Epilepsy and brain tumors: Two sides of the same coin.
Topics: Anticonvulsants; Brain Neoplasms; Epilepsy; Humans; Levetiracetam; Valproic Acid | 2023 |
Let food be thy medicine. The interaction between ketogenic diet therapy and anti-seizure medications: A systematic review.
Topics: Anticonvulsants; Child; Diet, Ketogenic; Epilepsy; Humans; Ketone Bodies; Topiramate; Valproic Acid | 2023 |
[Medical Treatment of Epilepsy].
Topics: Anticonvulsants; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam; Seizures; Valproic Acid | 2023 |
Management of epilepsy during pregnancy and lactation.
Topics: Breast Feeding; Epilepsy; Female; Humans; Lactation; Pregnancy; Prospective Studies; Seizures; Valpr | 2023 |
Risk factors of hyperammonemia in epilepsy patients with valproic acid therapy.
Topics: Adult; Ammonia; Anticonvulsants; Epilepsy; Humans; Hyperammonemia; Risk Factors; Topiramate; Valproi | 2023 |
Bipolar mania and epilepsy pathophysiology and treatment may converge in purine metabolism: A new perspective on available evidence.
Topics: Adenosine; Adenosine Triphosphate; Antimanic Agents; Bipolar Disorder; Epilepsy; Humans; Hydrocortis | 2023 |
Effects of Second-Generation Antiepileptic Drugs Compared to First-Generation Antiepileptic Drugs on Bone Metabolism in Patients with Epilepsy: A Meta-Analysis.
Topics: Anticonvulsants; Bone and Bones; Carbamazepine; Clinical Trials as Topic; Epilepsy; Humans; Lamotrig | 2019 |
Effects of valproic acid on bone mineral density and bone metabolism: A meta-analysis.
Topics: Anticonvulsants; Bone and Bones; Bone Density; Epilepsy; Humans; Valproic Acid | 2019 |
L-carnitine supplementation as a potential therapy for suspected hyperammonaemic encephalopathy.
Topics: Adult; Anticonvulsants; Blood Chemical Analysis; Carnitine; Cerebral Palsy; Dietary Supplements; Epi | 2019 |
Valproate, sexual health, and men: A narrative review.
Topics: Anticonvulsants; Epilepsy; Erectile Dysfunction; Female; Humans; Male; Sexual Behavior; Sexual Dysfu | 2020 |
Therapeutic Drug Monitoring of Antiepileptic Drugs in Women with Epilepsy Before, During, and After Pregnancy.
Topics: Anticonvulsants; Drug Monitoring; Epilepsy; Female; Humans; Postpartum Period; Pregnancy; Pregnancy | 2020 |
Pharmacodynamic interactions of antiepileptic drugs: From bench to clinical practice.
Topics: Animals; Anticonvulsants; Drug Evaluation, Preclinical; Drug Interactions; Drug Therapy, Combination | 2020 |
Effects of valproic acid on skeletal metabolism in children with epilepsy: a systematic evaluation and meta-analysis based on 14 studies.
Topics: Anticonvulsants; Bone Density; Child; Epilepsy; Female; Humans; Male; Retrospective Studies; Valproi | 2020 |
Expert opinion: use of valproate in girls and women of childbearing potential with epilepsy: recommendations and alternatives based on a review of the literature and clinical experience-a European perspective.
Topics: Anticonvulsants; Child; Epilepsy; Epilepsy, Generalized; Female; Humans; Pregnancy; Pregnancy Compli | 2021 |
Influence of CYP2C9 and CYP2A6 on plasma concentrations of valproic acid: a meta-analysis.
Topics: Anticonvulsants; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2C9; Epilepsy; Humans; Valproic Acid | 2020 |
Lessons learned from the discovery of sodium valproate and what has this meant to future drug discovery efforts?
Topics: Animals; Anticonvulsants; Drug Design; Drug Development; Drug Discovery; Drug Repositioning; Epileps | 2020 |
The changes of serum zinc, copper, and selenium levels in epileptic patients: a systematic review and meta-analysis.
Topics: Anticonvulsants; Copper; Diet; Epilepsy; Humans; Selenium; Trace Elements; Valproic Acid; Zinc | 2020 |
Epilepsy in Angelman syndrome: A scoping review.
Topics: Angelman Syndrome; Anticonvulsants; Child; Child, Preschool; Electroencephalography; Epilepsy; Femal | 2021 |
[Transfer Mechanisms of Compounds between Mother and Fetus/Infant Aimed for Optimized Medication during Pregnancy and Breastfeeding].
Topics: Anticonvulsants; Benzodiazepines; Biological Transport; Breast Feeding; Cell Line; Epilepsy; Female; | 2020 |
The characterization of psychotic symptoms in succinic semialdehyde dehydrogenase deficiency: a review.
Topics: Adolescent; Age of Onset; Aggression; Amino Acid Metabolism, Inborn Errors; Anticonvulsants; Anxiety | 2020 |
Reproductive health in patients with epilepsy.
Topics: Anticonvulsants; Epilepsy; Female; Gonadal Steroid Hormones; Humans; Infertility, Female; Infertilit | 2020 |
Use of Phenytoin, Phenobarbital Carbamazepine, Levetiracetam Lamotrigine and Valproate in Pregnancy and Breastfeeding: Risk of Major Malformations, Dose-dependency, Monotherapy vs Polytherapy, Pharmacokinetics and Clinical Implications.
Topics: Anticonvulsants; Breast Feeding; Carbamazepine; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam | 2021 |
Cosmetic adverse effects of antiseizure medications; A systematic review.
Topics: Animals; Anticonvulsants; Epilepsy; Humans; Phenytoin; Quality of Life; Valproic Acid | 2021 |
Initial Management of Seizure in Adults.
Topics: Adolescent; Adult; Anticonvulsants; Diagnosis, Differential; Electroencephalography; Epilepsy; Ethan | 2021 |
Effects of Sodium Valproate Monotherapy on Blood Liver Enzyme Levels in Patients with Epilepsy: A Meta-Analysis.
Topics: Alanine Transaminase; Anticonvulsants; Aspartate Aminotransferases; Epilepsy; gamma-Glutamyltransfer | 2021 |
Neuropharmacology of Antiseizure Drugs.
Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Humans; Neuropharmacology; Ph | 2021 |
Pregnancy Outcomes Following In Utero Exposure to Lamotrigine: A Systematic Review and Meta-Analysis.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant, Newbo | 2017 |
Association between switching antiepileptic drug products and healthcare utilization: A systematic review.
Topics: Adult; Anticonvulsants; Drug Substitution; Drugs, Generic; Epilepsy; Female; Fructose; Humans; Levet | 2017 |
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.
Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Epilepsies, Parti | 2017 |
Comparative safety of antiepileptic drugs for neurological development in children exposed during pregnancy and breast feeding: a systematic review and network meta-analysis.
Topics: Anticonvulsants; Autistic Disorder; Bayes Theorem; Breast Feeding; Carbamazepine; Child; Epilepsy; F | 2017 |
The pharmacogenomics of valproic acid.
Topics: Anticonvulsants; Bipolar Disorder; Cytochrome P-450 Enzyme System; Drug Delivery Systems; Epilepsy; | 2017 |
Relevance of CYP2C9 Function in Valproate Therapy.
Topics: Adult; Age Factors; Anticonvulsants; Biosynthetic Pathways; Child; Cytochrome P-450 CYP2C9; Epilepsy | 2019 |
Effect of UGT2B7 genotypes on plasma concentration of valproic acid: a meta-analysis.
Topics: Anticonvulsants; Chi-Square Distribution; Epilepsy; Gene Frequency; Glucuronosyltransferase; Heteroz | 2018 |
Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data.
Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Child; Cyclohexanecarboxylic Acids; Epilepsies, Parti | 2017 |
Comparative efficacy of antiepileptic drugs in children and adolescents: A network meta-analysis.
Topics: Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Carbamazepine; Ch | 2018 |
The effect of antiepileptic drugs on thyroid hormonal function: valproic acid and phenobarbital.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Hypothyroidism; Inci | 2020 |
Valproate: life-saving, life-changing.
Topics: Anticonvulsants; England; Epilepsy; Female; Humans; Maternal Exposure; Practice Guidelines as Topic; | 2018 |
Sodium valproate in pregnancy: what are the risks and should we use a shared decision-making approach?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Decision Making; E | 2018 |
[Valproate in the treatment of epilepsy and status epilepticus].
Topics: Anticonvulsants; Epilepsy; Humans; Status Epilepticus; Valproic Acid | 2017 |
Effects of valproate on reproductive endocrine function in male patients with epilepsy: A systematic review and meta-analysis.
Topics: Anticonvulsants; Epilepsy; Follicle Stimulating Hormone; Humans; Male; Observational Studies as Topi | 2018 |
Lesson of the month 1: Sodium valproate-induced encephalopathy.
Topics: Aged; Ammonia; Anticonvulsants; Brain Diseases; Carnitine; Consciousness Disorders; Epilepsy; Humans | 2018 |
Association between SCN1A polymorphism rs3812718 and valproic acid resistance in epilepsy children: a case-control study and meta-analysis.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Resistance; Epilepsy; Female; Genetic Ass | 2018 |
Valproic Acid and Epilepsy: From Molecular Mechanisms to Clinical Evidences.
Topics: Animals; Anticonvulsants; Brain Injuries, Traumatic; Epilepsy; Histone Deacetylases; Humans; Neurons | 2019 |
'Conceivably Neglected' - Are prescribers sufficiently aware of the risks of prescribing sodium valproate to women with mental illness?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Epilepsy; Female; | 2019 |
Valproic acid and Stevens-Johnson syndrome: a systematic review of descriptive studies.
Topics: Anticonvulsants; Antimanic Agents; Bipolar Disorder; Dose-Response Relationship, Drug; Epilepsy; Hum | 2019 |
Choice of therapeutic anti-seizure medication in patients with brain tumour.
Topics: Anticonvulsants; Brain Neoplasms; Drug Therapy, Combination; Epilepsy; Gabapentin; Glioma; Humans; L | 2019 |
Valproic Acid and the Liver Injury in Patients with Epilepsy: An Update.
Topics: Anticonvulsants; Antioxidants; Carnitine; Chemical and Drug Induced Liver Injury; Epilepsy; Humans; | 2019 |
Epilepsy in patients with EAST syndrome caused by mutation in the KCNJ10.
Topics: Anticonvulsants; Brain; Carbamazepine; Cerebellar Ataxia; Child; Child, Preschool; Epilepsy; Female; | 2019 |
Risk of valproic acid-related alopecia: A systematic review and meta-analysis.
Topics: Alopecia; Anticonvulsants; Epilepsy; Humans; Incidence; Prospective Studies; Valproic Acid | 2019 |
CPS1 T1405N polymorphism, HDL cholesterol, homocysteine and renal function are risk factors of VPA induced hyperammonemia among epilepsy patients.
Topics: Anticonvulsants; Carbamoyl-Phosphate Synthase (Ammonia); Case-Control Studies; Cholesterol, HDL; Epi | 2019 |
Valproate decreases vitamin D levels in pediatric patients with epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Humans; Valproic Acid | 2019 |
Clinical opinion: Earlier employment of polytherapy in sequential pharmacotherapy of epilepsy.
Topics: Anticonvulsants; Drug Resistant Epilepsy; Drug Therapy, Combination; Epilepsy; Humans; Lamotrigine; | 2019 |
Seizures and intracranial hemorrhage.
Topics: Anticonvulsants; Carbamazepine; Congenital Abnormalities; Eclampsia; Epilepsy; Female; Folic Acid; H | 2013 |
The effects of sodium valproate on the renal function of children with epilepsy.
Topics: Acetylglucosaminidase; Anticonvulsants; Child; Epilepsy; Fanconi Syndrome; Female; Humans; Kidney; M | 2014 |
Adverse drug reactions induced by valproic acid.
Topics: Anticonvulsants; Antipsychotic Agents; Drug Hypersensitivity; Endocrine System; Epilepsy; Humans; Hy | 2013 |
Metabolic and endocrine effects of valproic acid chronic treatment.
Topics: Anticonvulsants; Epilepsy; Humans; Hyperinsulinism; Insulin Resistance; Leptin; Metabolic Syndrome; | 2013 |
The search for better epilepsy treatments: from slime mould to coconuts.
Topics: Animals; Anticonvulsants; Cocos; Dictyostelium; Drug Discovery; Epilepsy; Humans; Valproic Acid | 2013 |
Weight change, genetics and antiepileptic drugs.
Topics: Animals; Anticonvulsants; Epilepsy; gamma-Aminobutyric Acid; Genetic Predisposition to Disease; Huma | 2014 |
Migraine and epilepsy in the pediatric population.
Topics: Anticonvulsants; Child; Child, Preschool; Comorbidity; Diagnosis, Differential; Diet, Ketogenic; Epi | 2014 |
Risks of neurobehavioral teratogenicity associated with prenatal exposure to valproate monotherapy: a systematic review with regulatory repercussions.
Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Bipolar Di | 2014 |
Treating epilepsy in pregnant women.
Topics: Anticonvulsants; Congenital Abnormalities; Epilepsy; Female; Humans; Intellectual Disability; Matern | 2014 |
WITHDRAWN: Traditional Chinese medicine for epilepsy.
Topics: Anticonvulsants; Drugs, Chinese Herbal; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Medicine, Chinese | 2014 |
Prediction of the hazard of foetal malformation in pregnant women with epilepsy.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Australia; Epilepsy; Female; Humans; Pregnancy; | 2014 |
[Clinical guidelines for epilepsy].
Topics: Anticonvulsants; Asia; Carbamazepine; Epilepsy; Europe; Evidence-Based Medicine; Humans; Internation | 2014 |
[Treatment of pediatric epilepsy].
Topics: Adolescent; Amines; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cyclohexanecarboxylic A | 2014 |
[Treatment of epilepsy in patients of adolescence and adulthood].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Combined Modality Therapy; Drug Substitution; Epi | 2014 |
Increased homocysteine levels in valproate-treated patients with epilepsy: a meta-analysis.
Topics: Anticonvulsants; Epilepsy; Homocysteine; Humans; Valproic Acid | 2014 |
Valproic acid and fatalities in children: a review of individual case safety reports in VigiBase.
Topics: Adverse Drug Reaction Reporting Systems; Anticonvulsants; Chemical and Drug Induced Liver Injury; Ch | 2014 |
Treatment for epilepsy in pregnancy: neurodevelopmental outcomes in the child.
Topics: Age Factors; Anticonvulsants; Carbamazepine; Child; Developmental Disabilities; Epilepsy; Female; Hu | 2014 |
[Epilepsy, antiepileptic drugs and disorders of reproductive functions of women].
Topics: Anticonvulsants; Epilepsy; Female; Fetal Diseases; Humans; Infertility, Female; Polycystic Ovary Syn | 2014 |
Valproate in the treatment of epilepsy in girls and women of childbearing potential.
Topics: Age Factors; Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Prenatal Exposure Delayed Effects | 2015 |
Pharmacological treatments for preventing epilepsy following traumatic head injury.
Topics: Adult; Anticonvulsants; Carbamazepine; Cause of Death; Child; Craniocerebral Trauma; Epilepsy; Human | 2015 |
[Algorithms of using valproic acid drugs in women].
Topics: Algorithms; Anticonvulsants; Contraindications; Epilepsy; Female; Humans; Pregnancy; Pregnancy Compl | 2015 |
Is carbamazepine a human teratogen?
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Australia; Carbamazepine; Epilepsy; Female; Fet | 2016 |
Valproic acid after five decades of use in epilepsy: time to reconsider the indications of a time-honoured drug.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Prenatal Exposure | 2016 |
Reflex epileptic mechanisms in ictogenesis and therapeutic consequences.
Topics: Epilepsies, Partial; Epilepsy; Epilepsy, Reflex; Humans; Seizures; Valproic Acid | 2016 |
[Preconceptional and perinatal challenges of pregnancy in women with epilepsy].
Topics: Adult; Amines; Anticonvulsants; Benzodiazepines; Carbamazepine; Cyclohexanecarboxylic Acids; Epileps | 2016 |
[Dynamin-1-related infantile spasms: a case report and review of literature].
Topics: Child; Child, Preschool; Developmental Disabilities; Dynamin I; Electroencephalography; Epilepsy; Fe | 2016 |
Menstrual cycle dysfunction associated with neurologic and psychiatric disorders: their treatment in adolescents.
Topics: Adolescent; Amenorrhea; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Bone and Bones; Epi | 2008 |
Teratogenicity of antiepileptic medications.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Drug Interactions; Drug Therapy, Combination; Epilepsy | 2008 |
[Diagnosis and treatment of epilepsy in the field of psychiatry].
Topics: Adult; Anticonvulsants; Carbamazepine; Diazepam; Electroencephalography; Epilepsy; Female; Humans; M | 2008 |
Epileptic disorders in pregnancy: an overview.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Folic Acid; Hemorrhag | 2008 |
Polycystic ovary syndrome in women using valproate: a review.
Topics: Antimanic Agents; Bipolar Disorder; Epilepsy; Female; Humans; Polycystic Ovary Syndrome; Prevalence; | 2008 |
Valproate-induced insulin resistance and obesity in children.
Topics: Anticonvulsants; Child; Epilepsy; Humans; Insulin Resistance; Obesity; Valproic Acid; Weight Gain | 2009 |
[Do results of the recent clinical trials change the place of valproate in treatment of epilepsy?].
Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; Humans; Seizures; Valproic Acid | 2008 |
Genetic basis for idiosyncratic reactions to antiepileptic drugs.
Topics: Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Epile | 2009 |
Practice parameter update: management issues for women with epilepsy--focus on pregnancy (an evidence-based review): teratogenesis and perinatal outcomes: report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Birth Weight; Cognition Disorders; Contraindications; | 2009 |
Management issues for women with epilepsy-Focus on pregnancy (an evidence-based review): II. Teratogenesis and perinatal outcomes: Report of the Quality Standards Subcommittee and Therapeutics and Technology Subcommittee of the American Academy of Neurolo
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Birth Weight; Cognition Disorders; Contraindications; | 2009 |
Traditional Chinese medicine for epilepsy.
Topics: Anticonvulsants; Drugs, Chinese Herbal; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Medicine, Chinese | 2009 |
Rational polytherapy.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Inter | 2009 |
Structure-function studies for the panacea, valproic acid.
Topics: Animals; Anticonvulsants; Bipolar Disorder; Epilepsy; gamma-Aminobutyric Acid; Glycogen Synthase Kin | 2009 |
New antiepileptic drugs: molecular targets.
Topics: Action Potentials; Animals; Anticonvulsants; Barbiturates; Carbamazepine; Clinical Trials as Topic; | 2009 |
[Homocysteine and asymmetric dimethylarginine (ADMA) in epilepsy].
Topics: Anticonvulsants; Arginine; Carbamazepine; Epilepsy; Homocysteine; Humans; Nitric Oxide; Nitric Oxide | 2009 |
Psychiatric concerns in pediatric epilepsy.
Topics: Adolescent; Amines; Anxiety Disorders; Bipolar Disorder; Child; Child, Preschool; Cyclohexanecarboxy | 2010 |
Molecular and therapeutic potential and toxicity of valproic acid.
Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; gamma-Aminobutyric Acid; Histone Deacetylase In | 2010 |
Molecular and therapeutic potential and toxicity of valproic acid.
Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; gamma-Aminobutyric Acid; Histone Deacetylase In | 2010 |
Molecular and therapeutic potential and toxicity of valproic acid.
Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; gamma-Aminobutyric Acid; Histone Deacetylase In | 2010 |
Molecular and therapeutic potential and toxicity of valproic acid.
Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; gamma-Aminobutyric Acid; Histone Deacetylase In | 2010 |
Molecular and therapeutic potential and toxicity of valproic acid.
Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; gamma-Aminobutyric Acid; Histone Deacetylase In | 2010 |
Molecular and therapeutic potential and toxicity of valproic acid.
Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; gamma-Aminobutyric Acid; Histone Deacetylase In | 2010 |
Molecular and therapeutic potential and toxicity of valproic acid.
Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; gamma-Aminobutyric Acid; Histone Deacetylase In | 2010 |
Molecular and therapeutic potential and toxicity of valproic acid.
Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; gamma-Aminobutyric Acid; Histone Deacetylase In | 2010 |
Molecular and therapeutic potential and toxicity of valproic acid.
Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; gamma-Aminobutyric Acid; Histone Deacetylase In | 2010 |
Weight gain following treatment with valproic acid: pathogenetic mechanisms and clinical implications.
Topics: Androgens; Anticonvulsants; Epilepsy; Female; Humans; Insulin Resistance; Male; Metabolic Syndrome; | 2011 |
Epilepsy (generalised).
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Epilepsy, Generalized; Humans; Incidence; Phenytoin; Remis | 2010 |
[Rational combinations of antiepileptic drugs for refractory epilepsy].
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbamazepine; Cl | 2011 |
[Pregabalin and gabapentin in multiple sclerosis: clinical experiences and therapeutic implications].
Topics: Adult; Aged; Aged, 80 and over; Amines; Anticonvulsants; Antineoplastic Agents; Carbamazepine; Cohor | 2011 |
A meta-analysis of polycystic ovary syndrome in women taking valproate for epilepsy.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Incidence; Polycystic Ovary Syndrome; Risk Factors; Valpr | 2011 |
Side effects of phenobarbital in epilepsy: a systematic review.
Topics: Anticonvulsants; Carbamazepine; Child; Cognition Disorders; Cohort Studies; Cross-Over Studies; Data | 2011 |
Takotsubo syndrome (TKS): a possible mechanism of sudden unexplained death in epilepsy (SUDEP).
Topics: Adrenergic beta-1 Receptor Antagonists; Anticonvulsants; Aspirin; Bisoprolol; Death, Sudden; Epileps | 2012 |
Management of acute seizure and status epilepticus in pediatric emergency.
Topics: Anesthesia, Intravenous; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Combined Modalit | 2012 |
Epilepsy (generalised).
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Epilepsy, Generalized; Humans; Incidence; Phenytoin; Remis | 2012 |
Efficacy and safety of innovator versus generic drugs in patients with epilepsy: a systematic review.
Topics: Anticonvulsants; Carbamazepine; Data Interpretation, Statistical; Dose-Response Relationship, Drug; | 2012 |
Neuroconnectivity and valproic acid: the myelin hypothesis.
Topics: Animals; Brain; Epilepsy; Humans; Models, Animal; Myelin Sheath; Neuroimaging; Valproic Acid | 2012 |
SCN1A IVS5N+5 polymorphism and response to sodium valproate: a multicenter study.
Topics: Adolescent; Adult; Alternative Splicing; Anticonvulsants; Asian People; Child; Cohort Studies; Epile | 2012 |
Extended-release antiepileptic drugs: a comparison of pharmacokinetic parameters relative to original immediate-release formulations.
Topics: Anticonvulsants; Carbamazepine; Delayed-Action Preparations; Drug Tolerance; Epilepsy; Humans; Valpr | 2013 |
[Medication-related oculogyric crises: a description of four cases and a review of the literature].
Topics: Adolescent; Anticonvulsants; Antipsychotic Agents; Aripiprazole; Child; Child Behavior Disorders; Ch | 2013 |
DP-VPA D-Pharm.
Topics: Animals; Bipolar Disorder; Clinical Trials, Phase II as Topic; Drug Evaluation, Preclinical; Epileps | 2002 |
Epilepsy and pregnancy.
Topics: Anticonvulsants; Embryonic and Fetal Development; Epilepsy; Female; Fetal Diseases; Folic Acid; Huma | 2002 |
Medical genetics: 1. Clinical teratology in the age of genomics.
Topics: Adult; Alcohol Drinking; Anticonvulsants; Environmental Exposure; Epilepsy; Female; Genetic Counseli | 2002 |
Pharmacological and therapeutic properties of valproate: a summary after 35 years of clinical experience.
Topics: Anticonvulsants; Clinical Trials as Topic; Drug Interactions; Epilepsy; History, 20th Century; Histo | 2002 |
Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dopamine; Epilepsy; Excitatory Amino Acids; gamma- | 2002 |
Valproate and neuroprotection.
Topics: Animals; Anticonvulsants; Biomarkers; Epilepsy; Humans; Neuroprotective Agents; Neurotransmitter Age | 2002 |
[Epilepsy with continuous spikes and waves during slow sleep].
Topics: Adolescent; Child; Clonazepam; Diagnosis, Differential; Drug Therapy, Combination; Electroencephalog | 2002 |
Drug treatment of epilepsy in elderly people: focus on valproic Acid.
Topics: Aged; Aging; Anticonvulsants; Clinical Trials as Topic; Drug Interactions; Epilepsy; Humans; Treatme | 2003 |
New CNS-active drugs which are second-generation valproic acid: can they lead to the development of a magic bullet?
Topics: Amides; Anticonvulsants; Bipolar Disorder; Epilepsy; Humans; Migraine Disorders; Valproic Acid | 2003 |
Pancreatic pseudocyst caused by valproic acid: case report and review of the literature.
Topics: Amylases; Anticonvulsants; Child; Epilepsy; Female; Humans; Pancreatic Pseudocyst; Pancreatitis; Val | 2003 |
Acute pancreatitis in children from Valproic acid: case series and review.
Topics: Acute Disease; Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Fatal Outcome; Female | 2003 |
A study of EEG and epilepsy profile in Wolf-Hirschhorn syndrome and considerations regarding its correlation with other chromosomal disorders.
Topics: Angelman Syndrome; Anticonvulsants; Child; Chromosome Deletion; Chromosome Disorders; Chromosomes, H | 2003 |
Polycystic ovary syndrome and epilepsy: a review of the evidence.
Topics: Adolescent; Adult; Anticonvulsants; Clinical Trials as Topic; Epilepsy; Female; Humans; Menstruation | 2003 |
Valproate: past, present, and future.
Topics: Animals; Anticonvulsants; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Epilep | 2003 |
Management issues for women with epilepsy: neural tube defects and folic acid supplementation.
Topics: Adult; Animals; Anticonvulsants; Carbamazepine; Cleft Lip; Cleft Palate; Epilepsy; Female; Folic Aci | 2003 |
Epilepsy: from consensus to daily practice.
Topics: Adult; Anticonvulsants; Decision Making; Drug Therapy, Combination; Epilepsy; Evidence-Based Medicin | 2003 |
Prevention of epilepsy after head trauma: do we need new drugs or a new approach?
Topics: Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Drug Administration Schedule; Epi | 2003 |
Divalproex and epilepsy.
Topics: Anticonvulsants; Drug Interactions; Epilepsy; Humans; Valproic Acid | 2003 |
[Clinical guidelines for treatment of epilepsy in children].
Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Cosyntropin; Electroencephalography; Epileps | 2004 |
[Effect of anti-epileptic drugs on human placenta and the fetus].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Embryonic and Fetal Development; Epilepsy; Female; Fet | 2004 |
Correlating lamotrigine serum concentrations with tolerability in patients with epilepsy.
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Drug Eruptions; Drug Interactions; Drug Therapy, | 2004 |
[Therapy of epilepsy: current strategy and tactics].
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Age Factors; Anticonvulsants; Carbamazepine; Child; | 2004 |
Cancer risk in people with epilepsy: the role of antiepileptic drugs.
Topics: Animals; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Neoplasms; Phenobarbital; Phenytoin; Rats | 2005 |
[A case of valproate-associated hyperammonemia with chronic hepatitis C].
Topics: Anticonvulsants; Epilepsy; Hepatitis C, Chronic; Humans; Hyperammonemia; Male; Middle Aged; Valproic | 2005 |
Teratogenicity of sodium valproate.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Animals; Autistic Disorder; Cleft Lip; | 2005 |
Pancreatitis, complicated by a pancreatic pseudocyst associated with the use of valproic acid.
Topics: Acute Disease; Anticonvulsants; Child; Epilepsy; Humans; Male; Pancreatic Pseudocyst; Pancreatitis; | 2005 |
Management of epilepsy in women.
Topics: Anticonvulsants; Child; Contraceptives, Oral, Combined; Contraindications; Developmental Disabilitie | 2005 |
Endocrine and metabolic changes in epileptic patients receiving valproic acid.
Topics: Anticonvulsants; Child; Endocrine System; Epilepsy; Humans; Valproic Acid | 2005 |
[Successful balloon-occluded retrograde transvenous obliteration (B-RTO) in a case of symptomatic epilepsy with hepatic encephalopathy due to non-cirrhotic porto-systemic shunt].
Topics: Aged; Anticonvulsants; Balloon Occlusion; Epilepsy; Hepatic Encephalopathy; Humans; Hyperammonemia; | 2005 |
Valproate: a simple chemical with so much to offer.
Topics: Anticonvulsants; Chemical and Drug Induced Liver Injury; Epilepsy; Female; History, 20th Century; Hu | 2005 |
Progress in pharmaceutical development presentation with improved pharmacokinetics: a new formulation for valproate.
Topics: Administration, Oral; Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Chemistry, Pharmaceutic | 2005 |
[Successful treatment with cyclosporine of sodium valproate-induced pure red cell aplasia].
Topics: Aged; Anticonvulsants; Cyclosporine; Epilepsy; Humans; Immunosuppressive Agents; Male; Red-Cell Apla | 2005 |
Valproic acid in epilepsy : pregnancy-related issues.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Autistic Disorder; Epilepsy; Female; Humans; Infant, N | 2006 |
Valproate as a mainstay of therapy for pediatric epilepsy.
Topics: Anticonvulsants; Child; Drug Monitoring; Epilepsy; Humans; Valproic Acid | 2006 |
Recent advances on neural tube defects with special reference to Valproic Acid.
Topics: Adult; Animals; Anticonvulsants; Epilepsy; Epoxide Hydrolases; Female; Folic Acid; Folic Acid Defici | 2006 |
New antiepileptic drugs that are second generation to existing antiepileptic drugs.
Topics: Amines; Animals; Anticonvulsants; Bipolar Disorder; Carbamazepine; Cyclohexanecarboxylic Acids; Drug | 2006 |
Role of valproate across the ages. Treatment of epilepsy in children.
Topics: Anticonvulsants; Child; Epilepsies, Myoclonic; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epi | 2006 |
Role of valproate across the ages. Treatment of epilepsy in adults.
Topics: Adult; Age Factors; Anticonvulsants; Child; Developmental Disabilities; Epilepsy; Female; Fertility; | 2006 |
Role of valproate across the ages. Treatment of epilepsy in the elderly.
Topics: Aged; Contraindications; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Tolerance; Epilepsy | 2006 |
[Epilepsy and male sexual dysfunction: etiology, diagnosis and therapy].
Topics: Androgens; Anticonvulsants; Bromocriptine; Carbamazepine; Cognition; Enzyme Induction; Epilepsy; Gon | 2006 |
Epilepsy and polycystic ovary syndrome: where is the link?
Topics: Epilepsy; Female; History, 20th Century; History, 21st Century; Humans; Models, Biological; Polycyst | 2006 |
Treatment of interictal epileptiform discharges in cerebral palsy patients without clinical epilepsy: hope for a better outcome in prognosis.
Topics: Calcium Channels; Cerebral Palsy; Electroencephalography; Epilepsy; Glutamic Acid; Humans; Intracell | 2007 |
Valproic Acid: second generation.
Topics: Animals; Anticonvulsants; Brain; Clinical Trials as Topic; Epilepsy; Humans; Structure-Activity Rela | 2007 |
[Anticonvulsants treatment of psychiatric disorder in elderly patients].
Topics: Aged; Anticonvulsants; Anxiety Disorders; Bipolar Disorder; Carbamazepine; Epilepsy; Humans; Mental | 2006 |
Therapeutic monitoring of antiepileptic drugs for epilepsy.
Topics: Anticonvulsants; Carbamazepine; Drug Monitoring; Epilepsy; Humans; Phenobarbital; Phenytoin; Primido | 2007 |
Antiepileptic drugs in migraine: from clinical aspects to cellular mechanisms.
Topics: Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; Fructose; Gabapentin; gamma | 2007 |
Teratogenesis of sodium valproate.
Topics: Anticonvulsants; Developmental Disabilities; Epilepsy; Female; Humans; Infant, Newborn; Intellectual | 2007 |
Idiosyncratic adverse reactions to antiepileptic drugs.
Topics: Age Factors; Anemia, Aplastic; Anticonvulsants; B-Lymphocytes; Central Nervous System Diseases; Chem | 2007 |
[The role of the antiepileptic drugs at the development of the sexual dysfunctions in male epileptic patients].
Topics: Anticonvulsants; Cytochrome P-450 Enzyme System; Drug Interactions; Epilepsy; Erectile Dysfunction; | 2007 |
Leptin and insulin homeostasis in epilepsy: relation to weight adverse conditions.
Topics: Animals; Anticonvulsants; Body Weight; Epilepsy; Homeostasis; Humans; Insulin; Leptin; Valproic Acid | 2007 |
The mechanisms of action of valproate in neuropsychiatric disorders: can we see the forest for the trees?
Topics: Animals; Anticonvulsants; beta Catenin; Bipolar Disorder; Brain; Enzyme Inhibitors; Epilepsy; Extrac | 2007 |
New statistical method for analyzing time to first seizure: example using data comparing carbamazepine and valproate monotherapy.
Topics: Adult; Age Factors; Anticonvulsants; Carbamazepine; Child; Data Interpretation, Statistical; Epileps | 2007 |
[New antiepileptics in development].
Topics: Animals; Anticonvulsants; Benzodiazepines; Carbamazepine; Epilepsy; Felbamate; Humans; Levetiracetam | 2007 |
Extended-release formulations for the treatment of epilepsy.
Topics: Animals; Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury; Delayed-Action Prep | 2007 |
The measurement of ammonia blood levels in patients taking valproic acid: looking for problems where they do not exist?
Topics: Ammonia; Anticonvulsants; Epilepsy; Female; Humans; Male; MEDLINE; Retrospective Studies; Valproic A | 2007 |
Epilepsy in Angelman syndrome.
Topics: Angelman Syndrome; Electroencephalography; Epilepsy; Humans; Valproic Acid | 2008 |
Valproate and neuroendocrine changes in relation to women treated for epilepsy and bipolar disorder: a review.
Topics: Anticonvulsants; Antimanic Agents; Bipolar Disorder; Contraceptives, Oral; Epilepsy; Female; Hormone | 2007 |
The treatment of the first seizure: the benefits.
Topics: Actuarial Analysis; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Phenobarbital; Prognosis; Rand | 2008 |
Oral valproic acid for epilepsy--long-term experience in therapy and side effects.
Topics: Administration, Oral; Animals; Anticonvulsants; Epilepsy; Gastrointestinal Diseases; Humans; Pancrea | 2008 |
Antiepileptic drugs as human teratogens.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Phenobarbital | 2008 |
Clinical pharmacology of parenteral use of antiepileptic drugs.
Topics: Anticonvulsants; Epilepsy; Humans; Infusions, Intravenous; Injections, Intravenous; Levetiracetam; P | 2007 |
Psychopharmacological aspects of antiepileptic treatment.
Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Electroencephalography; Epilepsy; Ethosux | 1980 |
[Advance and clinic of antiepileptic drugs (author's transl)].
Topics: Animals; Anticonvulsants; Benzodiazepines; Brain; Carbamazepine; Epilepsy; Humans; Ion Channels; Mic | 1981 |
Mechanism of anticonvulsant action of valproate.
Topics: Animals; Aspartic Acid; Cats; Central Nervous System; Epilepsy; gamma-Aminobutyric Acid; Half-Life; | 1982 |
Pharmacology of GABA.
Topics: 4-Aminobutyrate Transaminase; Anxiety Disorders; Autonomic Nervous System; Barbiturates; Benzodiazep | 1982 |
Diagnosis and treatment of epilepsy.
Topics: Automatism; Benzodiazepines; Carbamazepine; Electroencephalography; Epilepsies, Partial; Epilepsy; E | 1983 |
[Use of phenobarbital in febrile convulsive crisis].
Topics: Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Nervous System Diseases; Phenobarbital; Recurr | 1983 |
Mental effects of antiepileptic medication: a review.
Topics: Adolescent; Adult; Anticonvulsants; Attention; Barbiturates; Brain Chemistry; Carbamazepine; Child; | 1983 |
Clinical pharmacokinetics of sodium valproate, carbamazepine and phenytoin. Level-dose ration and interactions.
Topics: Carbamazepine; Drug Interactions; Epilepsy; Humans; Intestinal Absorption; Kinetics; Phenytoin; Valp | 1984 |
[Current progress in research and treatment of epilepsy].
Topics: Animals; Brain; Clonazepam; Disease Models, Animal; Electroencephalography; Epilepsy; Humans; Kindli | 1984 |
Visually-induced seizures.
Topics: Corpus Callosum; Electroencephalography; Epilepsy; Geniculate Bodies; Humans; Light; Models, Neurolo | 1980 |
Pharmacological principles in the long-term treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Epilepsy; Ethosuximide; Humans; Kinetics; Long | 1981 |
The epileptic mother and her child.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Breast Feeding; Carbamazepine; Epilepsy; Female; Fetal | 1982 |
Recent developments in the diagnosis and therapy of epilepsy.
Topics: Anticonvulsants; Biofeedback, Psychology; Carbamazepine; Clonazepam; Clorazepate Dipotassium; Condit | 1982 |
Controlled trials in epilepsy: a review.
Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Carbamazepine; Clinical Trials as Topic; Double-Blin | 1982 |
Use of antiepileptic drugs in the presence of liver and kidney diseases: a review.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Half-Life; Humans; Kidney Diseases; Kinetics; Liver Diseas | 1982 |
Therapeutic monitoring of valproic acid.
Topics: Aging; Animals; Autoradiography; Drug Evaluation; Drug Interactions; Epilepsy; Half-Life; Humans; Ki | 1980 |
Status epilepticus.
Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Brain; Electroencephalography; Epilepsy; Female; Hum | 1995 |
Valproic acid. A reappraisal of its pharmacological properties and clinical efficacy in epilepsy.
Topics: Adult; Aged; Aging; Animals; Anticonvulsants; Child; Clinical Trials as Topic; Drug Interactions; El | 1994 |
Mechanisms of action of currently prescribed and newly developed antiepileptic drugs.
Topics: Acetates; Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Drugs, Investigational; Epi | 1994 |
Pregnancy, teratogenesis, and epilepsy.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Epilepsy; Female; Fetus; Humans; Infant, Newb | 1994 |
The involvement of taurine in the action mechanism of sodium valproate (VPA) in the treatment of epilepsy.
Topics: Brain; Epilepsy; Humans; Taurine; Valproic Acid | 1993 |
Can we develop improved derivatives of valproic acid?
Topics: Animals; Anticonvulsants; Biotransformation; Drug Evaluation, Preclinical; Epilepsy; Fatty Acids, Mo | 1994 |
Standard approach to antiepileptic drug treatment in the United States.
Topics: Adult; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Drug Administration Schedule; Drug Th | 1994 |
Standard approach to antiepileptic drug treatment in the United Kingdom.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Administration Schedule; Drug Monitor | 1994 |
Handling seizure data: special problems.
Topics: Anticonvulsants; Clinical Trials as Topic; Data Interpretation, Statistical; Drug Therapy, Combinati | 1993 |
Pharmacologic intervention and treatment of childhood seizure disorders: relative efficacy and safety of antiepileptic drugs.
Topics: Animals; Anticonvulsants; Carbamazepine; Child; Clinical Trials as Topic; Drug Administration Schedu | 1994 |
[Contribution of new drugs to the better control of epilepsy].
Topics: Aminocaproates; Anticonvulsants; Child; Delayed-Action Preparations; Epilepsy; Felbamate; Humans; Ph | 1993 |
[A case of acute pancreatitis during administration of valproic acid].
Topics: Acute Disease; Adolescent; Epilepsy; Humans; Male; Pancreatitis; Valproic Acid | 1993 |
Clinical pharmacokinetics of antiepileptic drugs in paediatric patients. Part I: Phenobarbital, primidone, valproic acid, ethosuximide and mesuximide.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Ethosuximide; Humans; Infant; Infant | 1995 |
Carnitine deficiency in epilepsy: Risk factors and treatment.
Topics: Carnitine; Epilepsy; Humans; Liver; Risk Factors; Valproic Acid; Vitamin B Deficiency | 1995 |
A case of esophageal perforation due to a pill-induced ulcer successfully treated with conservative measures.
Topics: Epilepsy; Esophageal Diseases; Esophageal Perforation; Humans; Male; Middle Aged; Tablets; Ulcer; Va | 1996 |
Drug interaction profile of topiramate.
Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Epile | 1996 |
Interactions of valproic acid with carbamazepine and its metabolites' concentrations, concentrations ratios, and level/dose ratios in epileptic children.
Topics: Carbamazepine; Child; Drug Interactions; Epilepsy; Female; Humans; Linear Models; Male; Valproic Aci | 1995 |
Mechanisms of action of antiepileptic drugs.
Topics: Acetates; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Epilepsy; GABA Antagonists; Gabapent | 1995 |
Antiepileptic drug mechanisms of action.
Topics: Acetates; Action Potentials; Amines; Animals; Anticonvulsants; Barbiturates; Benzodiazepines; Calciu | 1995 |
Altered cognitive functioning in children with idiopathic epilepsy receiving valproate monotherapy.
Topics: Anticonvulsants; Child; Clinical Trials as Topic; Cognition; Epilepsy; Humans; Multicenter Studies a | 1996 |
Antiepileptic drugs--current use.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Phenytoin; Valproic Acid | 1996 |
[Advantages and disadvantages of new antiepileptic drugs].
Topics: Acetates; Adrenocorticotropic Hormone; Amines; Anticonvulsants; Brain; Cyclohexanecarboxylic Acids; | 1996 |
Established antiepileptic drugs.
Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Carbamazepine; Epilepsy; Humans; Phenytoin; Succinim | 1996 |
New drug therapy for acute seizure management.
Topics: Acute Disease; Anticonvulsants; Child; Diazepam; Epilepsy; Humans; Phenytoin; Prodrugs; Seizures; Va | 1997 |
Adverse effects in epilepsy therapy. Wait and see or go for it?
Topics: Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Epilepsy; Humans; MEDLINE; Valproic Acid | 1997 |
Pharmacologic and dietary therapies in epilepsy: conventional treatments and recent advances.
Topics: Acetates; Amines; Anticonvulsants; Benzodiazepines; Carbamazepine; Cyclohexanecarboxylic Acids; Epil | 1997 |
Pharmacokinetic interactions with felbamate. In vitro-in vivo correlation.
Topics: Anticonvulsants; Area Under Curve; Carbamazepine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-4 | 1997 |
Adult experience with lamotrigine.
Topics: Adult; Anticonvulsants; Drug Interactions; Epilepsy; Humans; Lamotrigine; Treatment Outcome; Triazin | 1997 |
Overview of lamotrigine and the new antiepileptic drugs: the challenge.
Topics: Acetates; Amines; Anticonvulsants; Child; Cyclohexanecarboxylic Acids; Drug Interactions; Epilepsy; | 1997 |
[Valproate induced parkinsonism].
Topics: Aged; Anticonvulsants; Epilepsy; Female; Humans; Male; Parkinson Disease, Secondary; Valproic Acid | 1998 |
Advances in the medical treatment of epilepsy.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Diazepam; Drug Approv | 1998 |
Features and management of poisoning with modern drugs used to treat epilepsy.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Phenytoin; Valproic Acid | 1998 |
Lamotrigine-induced severe cutaneous adverse reactions.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combin | 1998 |
Fortnightly review: drug treatment of epilepsy.
Topics: Acetates; Amines; Anti-Anxiety Agents; Anticonvulsants; Barbiturates; Benzodiazepines; Clobazam; Clo | 1999 |
Valproate in the treatment of epilepsy in people with intellectual disability.
Topics: Anticonvulsants; Epilepsy; Humans; Intellectual Disability; Treatment Outcome; Valproic Acid | 1998 |
Options after the first antiepileptic drug has failed.
Topics: Acetates; Amines; Anticonvulsants; Attitude to Health; Carbamazepine; Clinical Trials as Topic; Cycl | 1999 |
Monostars: an aid to choosing an antiepileptic drug as monotherapy.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Administration S | 1999 |
Lamotrigine.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Child; Clinical Trials as Topic; Diplopia; Dizziness; D | 1999 |
Is valproate pharmacotherapy associated with polycystic ovaries?
Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; Female; Humans; Ovarian Cysts; Valproic Acid | 1999 |
[Photogenic epilepsy].
Topics: Adolescent; Adult; Animals; Anticonvulsants; Child; Child, Preschool; Electroencephalography; Epilep | 2000 |
Carbamazepine versus valproate monotherapy for epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Confidence Intervals; Epilepsy; Humans; Outcome Assess | 2000 |
Is generic prescribing acceptable in epilepsy?
Topics: Anticonvulsants; Area Under Curve; Biological Availability; Carbamazepine; Chemistry, Pharmaceutical | 2000 |
Idiosyncratic reactions: new methods of identifying high-risk patients.
Topics: Anticonvulsants; Biomarkers; Drug Monitoring; Epilepsy; Epoxide Hydrolases; Felbamate; Free Radical | 2000 |
Therapeutic safety monitoring: what to look for and when to look for it.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Monitoring; Epil | 2000 |
New antiepileptic drugs and preparations.
Topics: Acetates; Administration, Rectal; Age Factors; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; | 2000 |
Valproic acid embryopathy: report of two siblings with further expansion of the phenotypic abnormalities and a review of the literature.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anticonvulsants; Epilepsy; Face; Female | 2001 |
[Febrile convulsions, Treatment and prognosis].
Topics: Analgesics, Non-Narcotic; Anticonvulsants; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Phe | 2001 |
Epilepsy therapy: issues for women and men.
Topics: Anticonvulsants; Congenital Abnormalities; Epilepsy; Epilepsy, Temporal Lobe; Female; Humans; Infert | 2001 |
[Studies of damaged processes in the nervous system and possibilities of neuroprotection].
Topics: Adult; Animals; Biomarkers; Calcium Channel Blockers; Child; Epilepsy; Evoked Potentials; Humans; Li | 2001 |
Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials.
Topics: Anticonvulsants; Brain Diseases; Brain Injuries; Carbamazepine; Controlled Clinical Trials as Topic; | 2001 |
On the association between valproate and polycystic ovary syndrome.
Topics: Adolescent; Adult; Anticonvulsants; Comorbidity; Epilepsy; Female; Humans; Hyperinsulinism; Insulin | 2001 |
On the association between valproate and polycystic ovary syndrome: a response and an alternative view.
Topics: Adolescent; Adult; Animals; Anticonvulsants; Child; Comorbidity; Epilepsy; Female; Fertility; Humans | 2001 |
Polycystic ovarian syndrome--relationship to epilepsy and antiepileptic drug therapy.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Polycystic Ovary Syndrome; Risk Factors; Valproic Acid | 2001 |
Cognitive side effects of anticonvulsants.
Topics: Acetates; Amines; Anticonvulsants; Bipolar Disorder; Carbamazepine; Cognition Disorders; Cyclohexane | 2001 |
Treatment of epilepsy in 3 specialized populations.
Topics: Age Factors; Aged; Anticonvulsants; Carbamazepine; Child; Drug Interactions; Epilepsy; Female; Human | 2001 |
The management of refractory idiopathic epilepsies.
Topics: Adolescent; Anticonvulsants; Child; Clinical Protocols; Drug Administration Schedule; Drug Therapy, | 2001 |
Polycystic ovarian syndrome in women with epilepsy: a review.
Topics: Adult; Anticonvulsants; Comorbidity; Epilepsy; Female; Finland; Follicle Stimulating Hormone; German | 2001 |
New antiepileptic drugs currently in clinical trials: is there a strategy in their development?
Topics: Anticonvulsants; Clinical Trials as Topic; Drug Design; Epilepsy; Humans; Valproic Acid | 2002 |
Tubulo-interstitial nephritis caused by sodium valproate.
Topics: Adolescent; Anticonvulsants; Biopsy; Epilepsy; Fanconi Syndrome; Female; Humans; Nephritis, Intersti | 2002 |
Carbamazepine versus valproate monotherapy for epilepsy: a meta-analysis.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; | 2002 |
Children versus adults: pharmacokinetic and adverse-effect differences.
Topics: Adolescent; Age Factors; Anticonvulsants; Chemical and Drug Induced Liver Injury; Child; Child, Pres | 2002 |
[Pharmacotherapy of epilepsy. II].
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Benzodiazepines; Carbamazepin | 1978 |
[Long-term anticonvulsant therapy (author's transl)].
Topics: Anticonvulsants; Carbamazepine; Chronic Disease; Clonazepam; Epilepsy; Ethosuximide; Humans; Long-Te | 1978 |
Valproic acid. Review of a new antiepileptic drug.
Topics: Adolescent; Adult; Animals; Brain Chemistry; Drug Interactions; Electric Stimulation; Electroencepha | 1979 |
The medical treatment of epilepsy: initiation of drug therapy.
Topics: Adolescent; Adrenocorticotropic Hormone; Anticonvulsants; Bromides; Carbamazepine; Child; Child, Pre | 1979 |
[Valproic acid in the treatment of epilepsy with special emphasis on serum level determination (author's transl)].
Topics: Blood Platelets; Drug Interactions; Electroencephalography; Epilepsy; Fatigue; Half-Life; Humans; Ph | 1978 |
Sodium valproate: a review of its pharmacological properties and therapeutic efficacy in epilepsy.
Topics: Administration, Oral; Adult; Animals; Anticonvulsants; Behavior; Blood Platelets; Child; Clinical Tr | 1977 |
Pharmacological prophylaxis in the kindling model of epilepsy.
Topics: Amygdala; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Atropine; Aziridines; Carba | 1977 |
Sodium di-N-propylacetate (DPA) in the treatment of epilepsy. A review.
Topics: Adolescent; Adult; Age Factors; Animals; Cerebral Cortex; Child; Child, Preschool; Drug Evaluation; | 1975 |
[Valproic acid and pregnancy: an unresolved problem. A clinical case].
Topics: Abnormalities, Drug-Induced; Adolescent; Cesarean Section; Epilepsy; Female; Humans; Infant, Newborn | 1992 |
Metabolism of antiepileptic medication: newborn to elderly.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Carbamazepine; Child; Dose-Response Relations | 1992 |
Problems in the assessment of cognitive effects of antiepileptic drugs.
Topics: Anticonvulsants; Cognition; Cognition Disorders; Epilepsy; Humans; Neuropsychological Tests; Researc | 1992 |
Antiepileptic drugs and their psychotropic effects.
Topics: Affect; Anticonvulsants; Brain; Carbamazepine; Clonazepam; Epilepsy; Humans; Mental Disorders; Psych | 1992 |
Pharmacokinetic evaluation of sustained release formulations of antiepileptic drugs. Clinical implications.
Topics: Absorption; Biological Availability; Carbamazepine; Delayed-Action Preparations; Epilepsy; Half-Life | 1992 |
[Acute pancreatitis and valproic acid].
Topics: Acute Disease; Child; Epilepsy; Humans; Male; Pancreatitis; Valproic Acid | 1991 |
Routine laboratory monitoring for serious adverse effects of antiepileptic medications: the controversy.
Topics: Anemia, Aplastic; Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury; Drug Monit | 1991 |
Antiepileptic drugs for children: carbamazepine and valproic acid derivatives.
Topics: Carbamazepine; Child; Electroencephalography; Epilepsy; Humans; Valproic Acid | 1991 |
Prescribing in epilepsy.
Topics: Anticonvulsants; Antidepressive Agents; Antipsychotic Agents; Drug Interactions; Epilepsy; Humans; V | 1990 |
The newer antiepileptic drugs: carbamazepine and valproic acid.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Interactions; Epilepsy; Humans; Infant | 1991 |
Valproate toxicity: risk-screening strategies.
Topics: Carnitine; Chemical and Drug Induced Liver Injury; Child; Enzymes; Epilepsy; Hepatic Encephalopathy; | 1991 |
Carnitine, valproate, and toxicity.
Topics: Carnitine; Chemical and Drug Induced Liver Injury; Child; Epilepsy; Hepatic Encephalopathy; Humans; | 1991 |
Carnitine, valproate, and toxicity.
Topics: Carnitine; Chemical and Drug Induced Liver Injury; Child; Epilepsy; Hepatic Encephalopathy; Humans; | 1991 |
Carnitine, valproate, and toxicity.
Topics: Carnitine; Chemical and Drug Induced Liver Injury; Child; Epilepsy; Hepatic Encephalopathy; Humans; | 1991 |
Carnitine, valproate, and toxicity.
Topics: Carnitine; Chemical and Drug Induced Liver Injury; Child; Epilepsy; Hepatic Encephalopathy; Humans; | 1991 |
Carnitine, valproate, and toxicity.
Topics: Carnitine; Chemical and Drug Induced Liver Injury; Child; Epilepsy; Hepatic Encephalopathy; Humans; | 1991 |
Carnitine, valproate, and toxicity.
Topics: Carnitine; Chemical and Drug Induced Liver Injury; Child; Epilepsy; Hepatic Encephalopathy; Humans; | 1991 |
Carnitine, valproate, and toxicity.
Topics: Carnitine; Chemical and Drug Induced Liver Injury; Child; Epilepsy; Hepatic Encephalopathy; Humans; | 1991 |
Carnitine, valproate, and toxicity.
Topics: Carnitine; Chemical and Drug Induced Liver Injury; Child; Epilepsy; Hepatic Encephalopathy; Humans; | 1991 |
Carnitine, valproate, and toxicity.
Topics: Carnitine; Chemical and Drug Induced Liver Injury; Child; Epilepsy; Hepatic Encephalopathy; Humans; | 1991 |
Antiepileptic drugs in affective illness. Clinical and theoretical implications.
Topics: Acute Disease; Anticonvulsants; Benzodiazepines; Bipolar Disorder; Carbamazepine; Depression; Drug T | 1991 |
[Acute fatal liver insufficiency due to valproic acid therapy].
Topics: Adult; Chemical and Drug Induced Liver Injury; Epilepsy; Hepatic Encephalopathy; Humans; Liver; Male | 1991 |
Valproate: an update--the challenge of modern pediatric seizure management.
Topics: Adolescent; Child; Epilepsy; Humans; Valproic Acid | 1990 |
Antiepileptic drugs, cognitive function, and behavior in children: evidence from recent studies.
Topics: Adult; Age Factors; Anticonvulsants; Carbamazepine; Child; Cognition; Cognition Disorders; Epilepsy; | 1990 |
[Late diagnosis of congenital argininemia during administration of sodium valproate].
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Ammonia; Arginine; Epilepsy; Female; Humans; Psych | 1990 |
The scope and use of valproate in epilepsy.
Topics: Epilepsy; Humans; Valproic Acid | 1989 |
[Fetal disease caused by sodium valproate. Apropos of a case].
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complic | 1989 |
[Valproate dosage].
Topics: Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Epilepsy; Humans; Valproic | 1989 |
The neuropharmacology of epileptic falling spells.
Topics: Anti-Anxiety Agents; Benzodiazepines; Brain; Electroencephalography; Epilepsy; Ethosuximide; Humans; | 1987 |
Sodium valproate.
Topics: Epilepsy; Humans; Liver; Valproic Acid | 1988 |
Valproate: an updated review.
Topics: Abnormalities, Drug-Induced; Brain Diseases; Chemical and Drug Induced Liver Injury; Coma; Dyskinesi | 1985 |
[GABAergic theory of epilepsy].
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Benzodiazepines; Bicuculline; Brain; Dogs; E | 1986 |
Epilepsy and the blood-brain barrier.
Topics: Animals; Animals, Newborn; Anticonvulsants; Biological Transport; Biomechanical Phenomena; Blood Pro | 1986 |
Use of ethosuximide and valproate in the treatment of epilepsy.
Topics: Abnormalities, Drug-Induced; Brain Diseases; Drug Interactions; Epilepsies, Myoclonic; Epilepsies, P | 1986 |
Antiepileptic drugs in adolescents.
Topics: Adaptation, Psychological; Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Dru | 1987 |
New anticonvulsants in pediatrics: carbamazepine and valproate.
Topics: Adolescent; Carbamazepine; Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Humans | 1987 |
Mechanisms of anticonvulsant drug action. II. Drugs primarily used for absence epilepsy.
Topics: Anticonvulsants; Benzodiazepines; Epilepsy; Ethosuximide; Humans; Kinetics; Valproic Acid | 1987 |
Teratogen update: valproic acid.
Topics: Abnormalities, Drug-Induced; Animals; Epidemiologic Methods; Epilepsy; Female; Humans; Infant, Newbo | 1987 |
Congenital malformations associated with maternal use of valproic acid.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Bone and Bones; Epilepsy; Facial Bones; Female | 1987 |
Febrile seizures.
Topics: Child; Child, Preschool; Diagnosis, Differential; Diazepam; Electroencephalography; Epilepsy; Female | 1987 |
Valproate monotherapy in the management of generalized and partial seizures.
Topics: Clinical Trials as Topic; Epilepsies, Partial; Epilepsy; Follow-Up Studies; Humans; Remission Induct | 1987 |
Valproate toxicity.
Topics: Child; Epilepsy; Humans; Valproic Acid | 1988 |
[Thyroid function in children under prolonged anticonvulsant therapy].
Topics: Anticonvulsants; Carbamazepine; Child; Epilepsy; Ethosuximide; Humans; Secretory Rate; Thyroid Gland | 1988 |
Three cases of delivery under sodium valproate--placental transfer, milk transfer and probable teratogenicity of sodium valproate.
Topics: Abnormalities, Drug-Induced; Adult; Epilepsy; Female; Fingers; Humans; Infant, Newborn; Male; Matern | 1988 |
Drug treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Ethosuximide; Humans; Ph | 1987 |
Comparison of monotherapy with valproate and other antiepileptic drugs in the treatment of seizure disorders.
Topics: Anticonvulsants; Epilepsies, Myoclonic; Epilepsies, Partial; Epilepsy; Humans; Valproic Acid | 1988 |
Review of valproate monotherapy in the treatment of generalized tonic-clonic seizures.
Topics: Anticonvulsants; Epilepsy; Humans; Valproic Acid | 1988 |
Pharmacokinetics of anti-epileptic drugs in the dog: a review.
Topics: Animals; Anticonvulsants; Blood Proteins; Carbamazepine; Clonazepam; Diazepam; Dog Diseases; Dogs; E | 1985 |
Trials
260 trials available for valproic acid and Aura
| Article | Year |
|---|---|
Lamotrigine versus levetiracetam or zonisamide for focal epilepsy and valproate versus levetiracetam for generalised and unclassified epilepsy: two SANAD II non-inferiority RCTs.
Topics: Child, Preschool; Cost-Benefit Analysis; Epilepsies, Partial; Epilepsy; Female; Humans; Lamotrigine; | 2021 |
Effect of Daily Vitamin D Supplementation on Serum Vitamin D Levels in Children with Epilepsy Receiving Sodium Valproate Monotherapy: A Randomized, Controlled Trial.
Topics: Alkaline Phosphatase; Calcium; Child; Dietary Supplements; Epilepsy; Humans; Parathyroid Hormone; Ph | 2023 |
Value of Group Intervention on Prognosis of Quality of Life in Epileptic Patients Treated With Sodium Valproate and Lamotrigine.
Topics: Epilepsy; Humans; Lamotrigine; Prognosis; Quality of Life; Valproic Acid | 2023 |
Population pharmacokinetics and exposure-safety of lipophilic conjugates prodrug DP-VPA in healthy Chinese subjects for dose regime exploring.
Topics: Drug-Related Side Effects and Adverse Reactions; East Asian People; Epilepsy; Healthy Volunteers; Hu | 2023 |
Cross-sectional evaluation of prescription of valproate and other antiepileptic drugs to pregnant women.
Topics: Anticonvulsants; Cross-Sectional Studies; Drug Prescriptions; Epilepsy; Female; Humans; Infant, Newb | 2021 |
Multi-drug therapy for epilepsy influenced bispectral index after a bolus propofol administration without affecting propofol's pharmacokinetics: a prospective cohort study.
Topics: Adult; Anesthesia, General; Anticonvulsants; Consciousness Monitors; Drug Interactions; Drug Therapy | 2020 |
A Phase II Randomized Trial to Explore the Potential for Pharmacokinetic Drug-Drug Interactions with Stiripentol or Valproate when Combined with Cannabidiol in Patients with Epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Area Under Curve; Cannabidiol; Dioxolanes; Dose-Response Relatio | 2020 |
Evaluate the effects of long-term valproic acid treatment on metabolic profiles in newly diagnosed or untreated female epileptic patients: A prospective study.
Topics: Adiponectin; Adolescent; Adult; Anticonvulsants; Blood Glucose; Body Mass Index; Cholesterol; Choles | 2017 |
An investigation on the effects of carbamazepine and sodium valproate on neuromuscular transmission.
Topics: Adult; Anticonvulsants; Carbamazepine; Electromyography; Epilepsy; Female; Humans; Male; Synaptic Tr | 2020 |
Evaluate the effects of antiepileptic drugs on reproductive endocrine system in newly diagnosed female epileptic patients receiving either Valproate or Lamotrigine monotherapy: A prospective study.
Topics: Adolescent; Adult; Anticonvulsants; Endocrine System; Epilepsy; Female; Follow-Up Studies; Hormones; | 2018 |
Unblinded, randomized multicenter trial comparing lamotrigine and valproate combination with controlled-release carbamazepine monotherapy as initial drug regimen in untreated epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Delayed-Action Preparations; Drug Therapy, Combination; Epile | 2018 |
Determinants of free serum valproate concentration: A prospective study in patients on divalproex sodium monotherapy.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Child; Dose-Response Relationship, Drug; Doub | 2018 |
Therapeutic drug monitoring of valproic acid.
Topics: Adult; Age Factors; Aged; Anticonvulsants; Child, Preschool; Drug Monitoring; Epilepsy; Female; Huma | 2018 |
Pharmacokinetics of lamotrigine in paediatric and young adult epileptic patients--nonlinear mixed effects modelling approach.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Interactions; Drug | 2014 |
Treatment outcome after failure of a first antiepileptic drug.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Fructose; Humans; Lamotrigine; Male; Middle Ag | 2014 |
Influence of valproic acid concentration and polymorphism of UGT1A4*3, UGT2B7 -161C > T and UGT2B7*2 on serum concentration of lamotrigine in Chinese epileptic children.
Topics: Adolescent; Anticonvulsants; Asian People; Child; Child, Preschool; Drug Therapy, Combination; Epile | 2015 |
Monotherapy with Levetiracetam Versus Older AEDs: A Randomized Comparative Trial of Effects on Bone Health.
Topics: Absorptiometry, Photon; Adult; Aged; Anticonvulsants; Bone and Bones; Bone Density; Bone Remodeling; | 2016 |
Carnitine and/or Acetylcarnitine Deficiency as a Cause of Higher Levels of Ammonia.
Topics: Acetylcarnitine; Adolescent; Adult; Aged; Aged, 80 and over; Ammonia; Bipolar Disorder; Carnitine; E | 2016 |
Valproate effect on ketosis in children under ketogenic diet.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Combined Modality Therapy; Diet, Ketogenic; Ep | 2016 |
Comparative effectiveness of levetiracetam, valproate and carbamazepine among elderly patients with newly diagnosed epilepsy: subgroup analysis of the randomized, unblinded KOMET study.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Levetiracetam; Ma | 2016 |
Association of UGT2B7 and UGT1A4 Polymorphisms with Serum Concentration of Antiepileptic Drugs in Children.
Topics: Adolescent; Anticonvulsants; Asian People; Base Sequence; Child; Child, Preschool; Epilepsy; Female; | 2016 |
Pharmacokinetic interaction of brivaracetam on carbamazepine in adult patients with epilepsy, with and without valproate co-administration.
Topics: Adult; Anticonvulsants; Biomarkers; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactio | 2016 |
Phenobarbital Versus Valproate for Generalized Convulsive Status Epilepticus in Adults: A Prospective Randomized Controlled Trial in China.
Topics: Administration, Intravenous; Adult; Anticonvulsants; China; Diazepam; Epilepsy; Female; Humans; Male | 2016 |
Brivaracetam population pharmacokinetics in children with epilepsy aged 1 month to 16 years.
Topics: Administration, Oral; Adolescent; Age Factors; Anticonvulsants; Carbamazepine; Child; Child, Prescho | 2017 |
Effect of antiepileptic drug polytherapy on urinary pH in children and young adults.
Topics: Acetazolamide; Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Ther | 2009 |
Hyperandrogenism, ovulatory dysfunction, and polycystic ovary syndrome with valproate versus lamotrigine.
Topics: Adolescent; Adult; Anovulation; Epilepsy; Female; Humans; Hyperandrogenism; Internationality; Lamotr | 2008 |
Treatment of status epilepticus and acute repetitive seizures with i.v. valproic acid vs phenytoin.
Topics: Acute Disease; Adult; Aged; Anticonvulsants; Brain; Drug-Related Side Effects and Adverse Reactions; | 2008 |
Lipid profile, apolipoproteins A and B in children with epilepsy.
Topics: Anticonvulsants; Apolipoproteins A; Apolipoproteins B; Carbamazepine; Case-Control Studies; Child; C | 2008 |
Conversion from valproic acid onto topiramate in adolescents and adults with epilepsy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Child; Dose-Response Relationship, Drug | 2009 |
Serum and muscle carnitine levels in epileptic children receiving sodium valproate.
Topics: Carnitine; Child; Child, Preschool; Enzyme Inhibitors; Epilepsy; Female; Humans; Male; Muscles; Seru | 2009 |
Seizure control and side-effect profile after switching adult epileptic patients from standard to extended-release divalproex sodium.
Topics: Activities of Daily Living; Adult; Anticonvulsants; Body Weight; Cohort Studies; Data Interpretation | 2009 |
Hyperammonemia following intravenous valproate loading.
Topics: Adult; Aged; Ammonia; Analysis of Variance; Anticonvulsants; Bilirubin; Dose-Response Relationship, | 2009 |
Effects of valproate or lamotrigine monotherapy on the reproductive endocrine and insulin-related metabolic profile in Chinese adults with epilepsy: a prospective randomized study.
Topics: Adolescent; Adult; Anticonvulsants; China; Cross-Sectional Studies; Dose-Response Relationship, Drug | 2009 |
The risk of asymptomatic hyperammonemia in children with idiopathic epilepsy treated with valproate: relationship to blood carnitine status.
Topics: Adolescent; Ammonia; Anticonvulsants; Carnitine; Child; Epilepsy; Female; Humans; Hyperammonemia; Ma | 2009 |
Effects of valproic acid on sleep in children with epilepsy.
Topics: Adolescent; Age Factors; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; | 2009 |
Reversible effects of antiepileptic drugs on thyroid hormones in men and women with epilepsy: a prospective randomized double-blind withdrawal study.
Topics: Adolescent; Adult; Age of Onset; Aged; Anticonvulsants; Carbamazepine; Double-Blind Method; Epilepsy | 2009 |
The influence of drug-drug interaction and patients' characteristics on valproic acid's clearance in adults with epilepsy using nonlinear mixed effects modeling.
Topics: Adult; Drug Interactions; Epilepsy; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Non | 2009 |
Effects of valproate, carbamazepine, and levetiracetam on the antioxidant and oxidant systems in epileptic patients and their clinical importance.
Topics: Adolescent; Adult; Anticonvulsants; Antioxidants; Aryldialkylphosphatase; Biomarkers; Carbamazepine; | 2010 |
Somatosensory evoked potentials in epileptic children treated with carbamazepine or valproate in monotherapy - a preliminary study.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Evoked Potentials, Somatosensory; Femal | 2010 |
[Comparative efficacy of carbamazepine, valproic acid and topiramate in symptomatic and cryptogenic occipital lobe epilepsy in children].
Topics: Adolescent; Anticonvulsants; Benzodiazepines; Brain Injuries; Carbamazepine; Child; Epilepsies, Part | 2010 |
Effects of epilepsy and antiepileptic drugs on nitric oxide, lipid peroxidation and xanthine oxidase system in children with idiopathic epilepsy.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Lipid Peroxidatio | 2011 |
Effects of carbamazepine and metabolites on IL-2, IL-5, IL-6, IL-10 and IFN-γ secretion in epileptic patients: the influence of co-medication.
Topics: Acridines; Adult; Aged; Anticonvulsants; Carbamazepine; Dibenzazepines; Drug Therapy, Combination; E | 2011 |
Valproate versus diazepam for generalized convulsive status epilepticus: a pilot study.
Topics: Adult; Aged; Anticonvulsants; Cerebrovascular Disorders; Diazepam; Drug Resistance; Electroencephalo | 2011 |
The effect of topiramate monotherapy on bone mineral density and markers of bone and mineral metabolism in premenopausal women with epilepsy.
Topics: Adult; Alkaline Phosphatase; Anticonvulsants; Bicarbonates; Bone and Bones; Bone Density; Calcificat | 2011 |
Effects of the abrupt switch from solution to modified-release granule formulation of valproate.
Topics: Anticonvulsants; Chemistry, Pharmaceutical; Child; Child, Preschool; Delayed-Action Preparations; Ep | 2012 |
Long-term control of epileptic drop attacks with the combination of valproate, lamotrigine, and a benzodiazepine: a 'proof of concept,' open label study.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Drug Therapy, Combinat | 2011 |
[Observation on therapeutic effect of acupoint catgut-embedding combined western medicine for epilepsy of generalized seizures type].
Topics: Acupuncture Points; Acupuncture Therapy; Adolescent; Adult; Anticonvulsants; Catgut; Child; Child, P | 2011 |
Population pharmacokinetics of valproic acid in pediatric patients with epilepsy: considerations for dosing spinal muscular atrophy patients.
Topics: Adolescent; Anticonvulsants; Capsules; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Ma | 2012 |
The effect of vitamin B supplementation on homocysteine metabolism and clinical state of patients with chronic epilepsy treated with carbamazepine and valproic acid.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Dietary Supplements; Epilepsy; Female; Foli | 2012 |
Impact of age, weight and concomitant treatment on lamotrigine pharmacokinetics.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Area Under Curve; Body Weight; Carbamazepine; Child | 2012 |
The effects of oxcarbazepine and valproate therapies on growth in children with epilepsy.
Topics: Adolescent; Anticonvulsants; Body Height; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; | 2012 |
Valproate sodium enhances body weight gain in patients with childhood epilepsy: a pathogenic mechanisms and open-label clinical trial of behavior therapy.
Topics: Adolescent; Anticonvulsants; Behavior Therapy; Body Mass Index; Child; Epilepsy; Female; Humans; Hyp | 2012 |
[Efficacy and safety of the combined therapy of valproic acid and lamotrigine for epileptics].
Topics: Child; Child, Preschool; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy; Epilepsy, Absence | 2012 |
SCN1A IVS5N+5 polymorphism and response to sodium valproate: a multicenter study.
Topics: Adolescent; Adult; Alternative Splicing; Anticonvulsants; Asian People; Child; Cohort Studies; Epile | 2012 |
Outcomes of sustained-release formulation of valproate and topiramate monotherapy in patients with epilepsy: a multi-centre, cohort study.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; China; Cohort Studies; Epilepsy; | 2012 |
Pharmacokinetic and pharmacodynamic effects of clonazepam in children with epilepsy treated with valproate: a preliminary study.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Chromatography, Gas; Chromatography, High Pres | 2002 |
Increase in postprandial serum insulin levels in epileptic patients with valproic acid therapy.
Topics: Adult; Anticonvulsants; Blood Glucose; Body Mass Index; Cholesterol; Cholesterol, LDL; Epilepsy; Fem | 2002 |
Safety and tolerance of rapidly infused Depacon. A randomized trial in subjects with epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Black People; Blood Pressure; Child; Child, Preschool; Dos | 2003 |
Valproate unbound fraction and distribution volume following rapid infusions in patients with epilepsy.
Topics: Adolescent; Adult; Aged; Algorithms; Anticonvulsants; Child; Child, Preschool; Dose-Response Relatio | 2003 |
Fasting serum insulin and lipid levels in men with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Body Mass Index; Carbamazepine; Epilepsy; Fasting; Humans; Hyper | 2003 |
Topiramate, carbamazepine and valproate monotherapy: double-blind comparison in newly diagnosed epilepsy.
Topics: Administration, Oral; Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Double-Blind M | 2003 |
Lamotrigine versus valproate monotherapy-associated weight change in adolescents with epilepsy: results from a post hoc analysis of a randomized, double-blind clinical trial.
Topics: Administration, Oral; Adolescent; Adult; Anticonvulsants; Body Mass Index; Child; Double-Blind Metho | 2003 |
[Influence of ivadal and depakene chrono on sleep structure in patients with epilepsy].
Topics: Adult; Delayed-Action Preparations; Drug Administration Schedule; Electroencephalography; Electroocu | 2003 |
The pharmacokinetics of oxcarbazepine and its active metabolite 10-hydroxy-carbazepine in healthy subjects and in epileptic patients treated with phenobarbitone or valproic acid.
Topics: Administration, Oral; Adult; Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy; Female; Ha | 1993 |
Lamotrigine monotherapy compared with carbamazepine, phenytoin, or valproate monotherapy in patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Evaluation | 2003 |
Thyroid function in girls with epilepsy with carbamazepine, oxcarbazepine, or valproate monotherapy and after withdrawal of medication.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Cross-Sectional Studies; Drug Administration Sche | 2004 |
Topiramate, carbamazepine, and valproate monotherapy: double-blind comparison in children with newly diagnosed epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Dose-Response Relationship, Drug; Double-Blind Me | 2004 |
The effect of valproate on bone mineral density in adult epileptic patients.
Topics: Absorptiometry, Photon; Adult; Anticonvulsants; Body Mass Index; Bone Density; Epilepsy; Female; Hum | 2004 |
Obesity and plasma concentrations of alpha-tocopherol and beta-carotene in epileptic girls treated with valproate.
Topics: Adolescent; alpha-Tocopherol; Anticonvulsants; Antioxidants; beta Carotene; Body Weight; Carotenoids | 2004 |
Reversible parkinsonism with normal beta-CIT-SPECT in patients exposed to sodium valproate.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Incidence; Male; Middle Aged; | 2004 |
Add-on melatonin improves quality of life in epileptic children on valproate monotherapy: a randomized, double-blind, placebo-controlled trial.
Topics: Anticonvulsants; Antioxidants; Child; Child, Preschool; Cross-Over Studies; Dose-Response Relationsh | 2004 |
Efficacy and tolerability of conversion to monotherapy with lamotrigine compared with valproate and carbamazepine in patients with epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Chi-Square Distribution; Drug Interactions; Drug Tolerance; E | 2004 |
Bone mineral metabolism changes in epileptic children receiving valproic acid.
Topics: Absorptiometry, Photon; Adolescent; Alkaline Phosphatase; Anticonvulsants; Bone Density; Bone Diseas | 2004 |
Rapid infusion with valproate sodium is well tolerated in patients with epilepsy.
Topics: Acute Disease; Anticonvulsants; Blood Pressure; Cohort Studies; Dose-Response Relationship, Drug; Dr | 2004 |
Topiramate pharmacokinetics in children with epilepsy aged from 6 months to 4 years.
Topics: Age Factors; Anticonvulsants; Area Under Curve; Biological Availability; Child, Preschool; Drug Admi | 2004 |
A randomized, double-blind, placebo controlled trial of melatonin add-on therapy in epileptic children on valproate monotherapy: effect on glutathione peroxidase and glutathione reductase enzymes.
Topics: Anticonvulsants; Antioxidants; Child; Child, Preschool; Double-Blind Method; Drug Therapy, Combinati | 2004 |
A dosing algorithm for converting from valproate monotherapy to lamotrigine monotherapy in patients with epilepsy.
Topics: Adolescent; Adult; Aged; Algorithms; Anticonvulsants; Confidence Intervals; Demography; Dose-Respons | 2005 |
Computerized tremor analysis of valproate-induced tremor: a comparative study of controlled-release versus conventional valproate.
Topics: Activities of Daily Living; Adolescent; Adult; Aged; Anticonvulsants; Delayed-Action Preparations; D | 2005 |
Extended-release divalproex in child and adolescent outpatients with epilepsy.
Topics: Adolescent; Age Factors; Ambulatory Care; Capsules; Child; Cross-Over Studies; Delayed-Action Prepar | 2005 |
Pharmacological outcomes in newly diagnosed epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, C | 2005 |
Visual function in epilepsy patients treated with initial valproate monotherapy.
Topics: Adult; Aged; Anticonvulsants; Color Perception; Contrast Sensitivity; Epilepsy; Female; Functional L | 2005 |
Successful initiation of combined therapy with valproate sodium injection and divalproex sodium extended-release tablets in the epilepsy monitoring unit.
Topics: Administration, Oral; Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Delayed-Act | 2005 |
Effectiveness of lamotrigine in clinical practice: results of a retrospective population-based study.
Topics: Adult; Anticonvulsants; Drug Interactions; Epilepsy; Female; Humans; Lamotrigine; Logistic Models; M | 2005 |
Analysis of pregabalin at therapeutic concentrations in human plasma/serum by reversed-phase HPLC.
Topics: Anticonvulsants; Calibration; Carbamazepine; Chromatography, High Pressure Liquid; Dose-Response Rel | 2005 |
[Acceptability and tolerance of sodium valproate, a new sustained-action granule formulation, in monotherapy for epileptic children from 3 years old].
Topics: Administration, Oral; Adolescent; Anticonvulsants; Child; Child, Preschool; Delayed-Action Preparati | 2005 |
[Valproate sustained release in the treatment of epilepsy].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Child; Delayed-Action Preparations; Epi | 2005 |
Plasma free carnitine in epilepsy children, adolescents and young adults treated with old and new antiepileptic drugs with or without ketogenic diet.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Carnitine; Child; Child, Preschool; Dietary Fats; | 2006 |
Serum insulin, leptin, and neuropeptide y levels in epileptic children treated with valproate.
Topics: Anticonvulsants; Blood Glucose; Body Mass Index; Child; Child, Preschool; Epilepsy; Female; Humans; | 2005 |
Every-12-hour administration of extended-release divalproex in patients with epilepsy: impact on plasma valproic acid concentrations.
Topics: Adult; Anticonvulsants; Biological Availability; Cross-Over Studies; Delayed-Action Preparations; Dr | 2006 |
Evolution of serum lipids and lipoprotein (a) levels in epileptic children treated with carbamazepine, valproic acid, and phenobarbital.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Diet; Epilepsy; Female; Humans; Lipids; Lipoprote | 2006 |
Effect of antiepileptic drugs on plasma lipids, lipoprotein (a), and liver enzymes.
Topics: Adolescent; Alkaline Phosphatase; Anticonvulsants; Apolipoproteins; Carbamazepine; Child; Child, Pre | 2006 |
Conversion from delayed-release sodium valproate to extended-release sodium valproate: initial results and long-term follow-up.
Topics: Anticonvulsants; Delayed-Action Preparations; Epilepsy; Follow-Up Studies; Humans; Patient Complianc | 2006 |
Add-on lamotrigine treatment and plasma glutamate levels in epilepsy: relation to treatment response.
Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Female; Glutamic Acid; Humans; Lamotrig | 2006 |
Quantitative EEG effects of carbamazepine, oxcarbazepine, valproate, lamotrigine, and possible clinical relevance of the findings.
Topics: Adolescent; Adult; Alpha Rhythm; Anticonvulsants; Carbamazepine; Child; Electroencephalography; Epil | 2006 |
Early and persistent increase in serum lipoprotein (a) concentrations in epileptic children treated with carbamazepine and sodium valproate monotherapy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Lipid | 2006 |
Color vision and macular recovery time in epileptic adolescents treated with valproate and carbamazepine.
Topics: Adolescent; Analysis of Variance; Anticonvulsants; Carbamazepine; Color Perception; Epilepsy; Female | 2006 |
Effects of anticonvulsant therapy on vitamin D status in children: prospective monitoring study.
Topics: Anticonvulsants; Calcium; Carbamazepine; Child; Epilepsy; Female; Follow-Up Studies; Humans; Male; P | 2006 |
Valproate effects on kinetics of lamotrigine in pregnancy and treatment with oral contraceptives.
Topics: Anticonvulsants; Contraceptives, Oral; Drug Combinations; Epilepsy; Female; Humans; Kinetics; Lamotr | 2006 |
Efficacy of carbamazepine and valproate as monotherapy for early epilepsy and single seizures.
Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Carbamazepine; Cohort Studies; Drug Administration | 2006 |
Influence of major antiepileptic drugs on attention, reaction time, and speed of information processing: results from a randomized, double-blind, placebo-controlled withdrawal study of seizure-free epilepsy patients receiving monotherapy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Attention; Carbamazepine; Cognition; Cognition Disorders; | 2006 |
Safety of rapid intravenous valproate infusion in pediatric patients.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Infusions, I | 2007 |
Safety of rapid intravenous loading of valproate.
Topics: Adult; Aged; Analysis of Variance; Anticonvulsants; Blood Pressure; Consciousness; Dose-Response Rel | 2007 |
Cognitive side effects of valproic acid-induced hyperammonemia in children with epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Cognition Disorders; Epilepsy; Female; Humans; Hyperammonemia; M | 2007 |
Inhibitory effect of valproic acid on cytochrome P450 2C9 activity in epilepsy patients.
Topics: Adolescent; Adult; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liq | 2007 |
The measurement and magnitude of awareness difficulties after traumatic brain injury: a longitudinal study.
Topics: Adult; Anticonvulsants; Awareness; Brain Injuries; Double-Blind Method; Epilepsy; Female; Glasgow Co | 2007 |
Antiepileptic drugs and the significance of event-related potentials.
Topics: Adult; Analysis of Variance; Anticonvulsants; Carbamazepine; Case-Control Studies; Electroencephalog | 2007 |
Sodium valproate versus lamotrigine: a randomised comparison of efficacy, tolerability and effects on circulating androgenic hormones in newly diagnosed epilepsy.
Topics: Adolescent; Adult; Aged; Androgens; Androstenedione; Anticonvulsants; Body Mass Index; Body Weight; | 2007 |
Reversible effects of antiepileptic drugs on reproductive endocrine function in men and women with epilepsy--a prospective randomized double-blind withdrawal study.
Topics: Adolescent; Adult; Aged; Androgens; Anticonvulsants; Carbamazepine; Double-Blind Method; Epilepsy; E | 2007 |
Valproate protein binding following rapid intravenous administration of high doses of valproic acid in patients with epilepsy.
Topics: Adult; Age Factors; Aged; Anticonvulsants; Body Weight; Dose-Response Relationship, Drug; Epilepsy; | 2007 |
Lack of pharmacokinetic interaction of levetiracetam on carbamazepine, valproic acid, topiramate, and lamotrigine in children with epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Interactions; Drug Therapy | 2007 |
A randomised controlled trial examining the longer-term outcomes of standard versus new antiepileptic drugs. The SANAD trial.
Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilepsy; Female; Fructo | 2007 |
An observational study of first-line valproate monotherapy in focal epilepsy.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Brain Diseases; Child; Delayed-Action Preparations; | 2008 |
Thyroid function and volume in epileptic children using carbamazepine, oxcarbazepine and valproate.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Hypot | 2007 |
The role of ghrelin in weight gain and growth in epileptic children using valproate.
Topics: Adolescent; Anticonvulsants; Blood Glucose; Body Height; Body Mass Index; Body Weight; C-Peptide; Ch | 2007 |
Potential relationships between transaminase abnormality and valproic acid clearance or serum carnitine concentrations in Japanese epileptic patients.
Topics: Adolescent; Adult; Ammonia; Anticonvulsants; Body Weight; Carnitine; Chemical and Drug Induced Liver | 2008 |
Attention changes in epilepsy patients following 3-month topiramate or valproate treatment revealed by event-related potential.
Topics: Adolescent; Adult; Attention; Case-Control Studies; Electroencephalography; Epilepsy; Evoked Potenti | 2008 |
Valproate affects reproductive endocrine function, testis diameter and some semen variables in non-epileptic adolescent goat bucks.
Topics: Animals; Anticonvulsants; Body Weight; Endocrine System; Epilepsy; Flow Cytometry; Goat Diseases; Go | 2008 |
Effect of valproic acid treatment on body composition, leptin and the soluble leptin receptor in epileptic children.
Topics: Adolescent; Anthropology, Physical; Anticonvulsants; Body Composition; Body Mass Index; Child; Cross | 2008 |
Serum concentrations and enzyme induction in epileptic children treated with phenytoin and valproate.
Topics: Child; Enzyme Induction; Epilepsy; gamma-Glutamyltransferase; Humans; Phenytoin; Valproic Acid | 1982 |
[Anti-epileptic agents during pregnancy. A prospective study on the course of pregnancy, malformations and child development].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Akathisia, Drug-Induced; Anencephaly; Ant | 1983 |
Developments in pharmacotherapy of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Epilepsy; Humans; Research Design; Valproi | 1983 |
Plasma concentrations of sodium valproate: their clinical value.
Topics: Clinical Trials as Topic; Dose-Response Relationship, Drug; Epilepsies, Partial; Epilepsy; Humans; V | 1983 |
Controlled and comparative trials of valproate performed in Europe and Asia.
Topics: Adolescent; Adult; Asia; Carbamazepine; Child; Clinical Trials as Topic; Epilepsy; Europe; Humans; P | 1984 |
Controlled and comparative trials with valproate: United States.
Topics: Adolescent; Adult; Child; Child, Preschool; Clinical Trials as Topic; Epilepsy; Epilepsy, Absence; E | 1984 |
l-Tryptophan in hyperactive child syndrome associated with epilepsy: a controlled study.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Carbamazepine; Child; Clinical Trials as | 1983 |
A randomised trial of strategies to improve patient compliance with anticonvulsant therapy.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Counseling; Drug Packag | 1984 |
Role of combination of valproic acid with diphenylhydantoin and carbamazepine in the management of intractable seizures.
Topics: Adolescent; Adult; Carbamazepine; Clinical Trials as Topic; Drug Therapy, Combination; Epilepsy; Fem | 1984 |
Clinical efficacy and long-term effects of valproic acid therapy on spike-and-wave discharges.
Topics: Clinical Trials as Topic; Electroencephalography; Epilepsies, Myoclonic; Epilepsy; Epilepsy, Absence | 1980 |
Pharmacokinetics of sodium valproate in epileptic patients: prediction of maintenance dosage by single-dose study.
Topics: Adolescent; Adult; Aged; Biological Availability; Child; Drug Administration Schedule; Epilepsy; Fem | 1980 |
The antiepileptic properties of N-dipropylacetamide (depamide): a clinical trial.
Topics: Adolescent; Adult; Anticonvulsants; Child; Clinical Trials as Topic; Epilepsy; Female; Humans; Male; | 1980 |
Individualized patient assessment in the treatment of epilepsy with sodium valproate.
Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; Clinical Trials as Topic; Epilepsy | 1980 |
Comparison of sodium valproate and phenytoin as single drug treatment in epilepsy.
Topics: Adolescent; Adult; Aged; Child; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Pregnancy; T | 1981 |
[Leptilan. Dissolution, bioavailability and first therapeutic results in children with different epilepsy forms].
Topics: Adolescent; Biological Availability; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Valpro | 1981 |
[The treatment of epilepsies with Convulsofin].
Topics: Adolescent; Adult; Alanine Transaminase; Aspartate Aminotransferases; Child; Child, Preschool; Clini | 1981 |
A comparison of phenytoin and valproate in previously untreated adult epileptic patients.
Topics: Adolescent; Adult; Age Factors; Aged; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Humans | 1982 |
Behavioral changes produced by valproic acid.
Topics: Adult; Behavior; Clinical Trials as Topic; Drug Interactions; Epilepsy; Humans; Male; Valproic Acid | 1982 |
Controlled trials in epilepsy: a review.
Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Carbamazepine; Clinical Trials as Topic; Double-Blin | 1982 |
Treatment of childhood epilepsy with valproic acid: results of the first 100 patients in a 6-month trial.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Clinical Trials as Topic; Epilepsy; Fem | 1980 |
Safety of intravenous valproate.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Epilepsy; Hospitalization; Huma | 1995 |
[Clinical usefulness of pediatric population parameter of slow-releasing preparation of sodium valproate].
Topics: Adolescent; Child; Delayed-Action Preparations; Epilepsy; Female; Humans; Male; Valproic Acid | 1995 |
Effect of valproate and carbamazepine on visual evoked potentials in epileptic children.
Topics: Carbamazepine; Child; Child, Preschool; Epilepsy; Evoked Potentials, Visual; Female; Humans; Male; N | 1995 |
A multiparametric investigation of daytime sleepiness and psychomotor functions in epileptic patients treated with phenobarbital and sodium valproate: a comparative controlled study.
Topics: Adult; Affect; Analysis of Variance; Epilepsy; Humans; Male; Neuropsychological Tests; Phenobarbital | 1993 |
[The enkorat treatment of infantile spasms and the Lennox-Gastaut syndrome].
Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Clonazepam; Drug Therapy, Combination; Epilepsy; E | 1994 |
Evaluation of binding equation method for prediction of unbound serum valproic acid concentration in pediatric patients with epilepsy.
Topics: Adolescent; Blood Proteins; Child; Child, Preschool; Epilepsy; Female; Fluorescence Polarization Imm | 1995 |
Effects of long-term treatment with antiepileptic drugs on serum lipid levels in children with epilepsy.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cholesterol; Cholesterol, HDL; Cholesterol, | 1995 |
Renal tubular dysfunction following treatment with anti-epileptic drugs.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cross-Sectional Studies; Epilep | 1994 |
Inhibition of phenobarbitone N-glucosidation by valproate.
Topics: Adult; Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Dose-Response Relationship, Dr | 1994 |
Thrombocytopenia secondary to high valproate levels in children with epilepsy.
Topics: Carbamazepine; Child; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Male; Platelet Cou | 1994 |
The effect of felbamate on valproic acid disposition.
Topics: Adult; Cross-Over Studies; Drug Therapy, Combination; Epilepsy; Felbamate; Female; Humans; Male; Phe | 1994 |
Sensitive capillary gas chromatographic-mass spectrometric method for the therapeutic drug monitoring of valproic acid and seven of its metabolites in human serum. Application of the assay for a group of pediatric epileptics.
Topics: Biotransformation; Child; Drug Monitoring; Epilepsy; Gas Chromatography-Mass Spectrometry; Humans; H | 1994 |
Long-term administration of valproic acid in the treatment of affective symptoms in people with mental retardation.
Topics: Adolescent; Adult; Child; Epilepsy; Female; Humans; Intellectual Disability; Male; Mood Disorders; P | 1993 |
A double-blind, placebo-controlled interaction study between oxcarbazepine and carbamazepine, sodium valproate and phenytoin in epileptic patients.
Topics: Adult; Anticonvulsants; Carbamazepine; Double-Blind Method; Drug Interactions; Epilepsy; Female; Hal | 1994 |
Does carnitine administration improve the symptoms attributed to anticonvulsant medications?: a double-blinded, crossover study.
Topics: Carbamazepine; Carnitine; Child; Double-Blind Method; Epilepsy; Female; Health Status; Humans; Male; | 1994 |
Pharmacokinetic comparison of two valproic acid formulations--a plain and a controlled release enteric-coated tablets.
Topics: Administration, Oral; Adult; Biological Availability; Delayed-Action Preparations; Epilepsy; Humans; | 1993 |
Developmental and therapeutic pharmacology of antiepileptic drugs.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Dru | 1993 |
Withdrawal of antiepileptic medication in children--effects on cognitive function: The Multicenter Holmfrid Study.
Topics: Adolescent; Carbamazepine; Child; Cognition; Cognition Disorders; Epilepsy; Female; Follow-Up Studie | 1993 |
Pharmacokinetic interaction between valproic acid and phenobarbital.
Topics: Administration, Oral; Adult; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Humans; | 1993 |
Psychiatric aspects of epilepsy in childhood treated with carbamazepine, phenytoin or sodium valproate: a random trial.
Topics: Adolescent; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Follow-Up Studies; Humans; Mal | 1993 |
Lamotrigine for the treatment of epilepsy in childhood.
Topics: Adolescent; Anticonvulsants; Body Weight; Child; Child, Preschool; Consumer Product Safety; Dose-Res | 1995 |
Relationship between valproic acid dosage, plasma concentration and clearance in adult monotherapy patients with epilepsy.
Topics: Administration, Oral; Adult; Anticonvulsants; Dose-Response Relationship, Drug; Drug Evaluation; Epi | 1995 |
A comparison of the OPUS and TDx analysers for antiepileptic drug monitoring.
Topics: Anticonvulsants; Carbamazepine; Drug Monitoring; Epilepsy; Female; Fluorescence Polarization Immunoa | 1995 |
Activities of antioxidant enzymes and formation of the glutathione adduct of hemoglobin (Hb ASSG) in epileptic patients with long-term antiepileptic therapy.
Topics: Anticonvulsants; Antioxidants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Erythrocytes; Fem | 1995 |
Randomised comparative monotherapy trial of phenobarbitone, phenytoin, carbamazepine, or sodium valproate for newly diagnosed childhood epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; | 1996 |
Comparison of antiepileptic drugs on cognitive function in newly diagnosed epileptic children: a psychometric and neurophysiological study.
Topics: Adolescent; Anticonvulsants; Bender-Gestalt Test; Carbamazepine; Child; Cognition; Epilepsy; Event-R | 1996 |
Assessment of drowsiness in epilepsy patients receiving chronic antiepileptic drug therapy.
Topics: Adult; Age Factors; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsy; Humans; Middle | 1996 |
The effect of carnitine supplementation in valproate-induced hyperammonaemia.
Topics: Adolescent; Adult; Ammonia; Anticonvulsants; Carnitine; Chemical and Drug Induced Liver Injury; Chil | 1996 |
Valproic acid treatment of learning disorder and severely epileptiform EEG without clinical seizures.
Topics: Anticonvulsants; Child; Electroencephalography; Epilepsy; Frontal Lobe; Humans; Learning Disabilitie | 1996 |
Pharmacokinetic interactions between lamotrigine and other antiepileptic drugs in children with intractable epilepsy.
Topics: Administration, Oral; Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cl | 1996 |
Antiepileptic drug treatment in pregnancy: drug side effects in the neonate and neurological outcome.
Topics: Anticonvulsants; Child; Drug Monitoring; Epilepsy; Female; Follow-Up Studies; Humans; Nervous System | 1996 |
Monitoring free extracellular valproic acid by microdialysis in epileptic patients.
Topics: Adult; Anticonvulsants; Chromatography, Gas; Epilepsy; Extracellular Space; Female; Humans; Male; Mi | 1996 |
Effect of valproate on cognitive functioning. Comparison with carbamazepine. The Department of Veterans Affairs Epilepsy Cooperative Study 264 Group.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Cognition; Double-Blind Method; Epilepsy; Female; Follo | 1996 |
Serum concentrations of lamotrigine in epileptic patients: the influence of dose and comedication.
Topics: Adult; Age Factors; Anticonvulsants; Body Weight; Carbamazepine; Dose-Response Relationship, Drug; D | 1996 |
[Depakine syrup in the treatment of therapy-resistant epilepsy].
Topics: Adolescent; Adult; Anticonvulsants; Chronic Disease; Drug Resistance; Electroencephalography; Epilep | 1996 |
Comparison of the steady-state pharmacokinetics of topiramate and valproate in patients with epilepsy during monotherapy and concomitant therapy.
Topics: Adult; Anticonvulsants; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; | 1997 |
Lamotrigine substitution study: evidence for synergism with sodium valproate? 105 Study Group.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Dose-Response Relationship, Drug; Drug Synergism; Epilepsy | 1997 |
Weight gain with valproate or carbamazepine--a reappraisal.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cross-Over Studies; Dose-Respon | 1997 |
The effectiveness of clonazepam on the Rolandic discharges.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Electroencephalography; Epileps | 1997 |
Lack of pharmacokinetic interaction between remacemide hydrochloride and sodium valproate in epileptic patients.
Topics: Acetamides; Adult; Anticonvulsants; Cross-Over Studies; Double-Blind Method; Drug Interactions; Epil | 1997 |
The mechanism of the carbamazepine-valproate interaction in humans.
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Mi | 1997 |
Weight gain in epileptic patients during treatment with valproic acid: a retrospective study.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Male; Middle Aged | 1997 |
Lamotrigine as add-on drug in children and adolescents with refractory epilepsy and mental delay: an open trial.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Developmental Disabilities; Drug Resist | 1997 |
Alterations in the carnitine metabolism in epileptic children treated with valproic acid.
Topics: Administration, Oral; Anticonvulsants; Carnitine; Child; Drug Therapy, Combination; Epilepsy; Female | 1997 |
Influence of caffeine on pharmacokinetic profile of sodium valproate and carbamazepine in normal human volunteers.
Topics: Anticonvulsants; Caffeine; Carbamazepine; Cross-Over Studies; Drug Interactions; Epilepsy; Humans; M | 1998 |
Cognitive effects of anticonvulsant monotherapy in elderly patients: a placebo-controlled study.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Cognition Disorders; Dose-Response Relation | 1998 |
Steady-state serum concentrations of carbamazepine and valproic acid in obese and lean patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Linear Models; Male; Va | 1998 |
Valproic acid clearance in children with epilepsy.
Topics: Age Factors; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Model | 1998 |
[Therapeutic failure, treatment and non-treatment of childhood epilepsy].
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Electroencephalography; Epileps | 1998 |
Serum carnitine levels in epileptic children before and during treatment with valproic acid, carbamazepine, and phenobarbital.
Topics: Adolescent; Animals; Anticonvulsants; Carbamazepine; Carnitine; Child; Child, Preschool; Epilepsy; H | 1998 |
Effect of antiepileptic drugs on bone mineral density in children between ages 6 and 12 years.
Topics: Anticonvulsants; Bone Density; Carbamazepine; Child; Epilepsy; Female; Humans; Lumbar Vertebrae; Mal | 1999 |
Does withdrawal of different antiepileptic drugs have different effects on seizure recurrence? Further results from the MRC Antiepileptic Drug Withdrawal Study.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Combinations; Epilepsy; Female; Human | 1999 |
Spotlight on the continual applicability of routine plasma monitoring antiepileptic drugs in the treatment of epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Monitoring; Drug Therapy, Combination; Epile | 1999 |
The efficacy of felbamate as add-on therapy to valproic acid in the Lennox-Gastaut syndrome.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Cross-Over Studies; Double-Blind Method; Drug | 1999 |
Safety and tolerability of gabapentin as adjunctive therapy in a large, multicenter study.
Topics: Acetates; Adolescent; Adult; Ambulatory Care; Amines; Anticonvulsants; Asthenia; Carbamazepine; Cycl | 1999 |
Comparative double blind clinical trial of phenytoin and sodium valproate as anticonvulsant prophylaxis after craniotomy: efficacy, tolerability, and cognitive effects.
Topics: Adult; Aged; Brain Diseases; Cognition; Craniotomy; Double-Blind Method; Epilepsy; Female; Humans; M | 1999 |
No effect of gender or age on binding characteristics of valproic acid to serum proteins in pediatric patients with epilepsy.
Topics: Adolescent; Age Factors; Anticonvulsants; Blood Proteins; Child; Child, Preschool; Epilepsy; Female; | 1999 |
[Depakin 300 and Depakin-chrono in the therapy of epilepsy].
Topics: Adolescent; Adult; Anticonvulsants; Chronic Disease; Electroencephalography; Epilepsy; Female; Human | 1999 |
A multicenter randomized controlled trial on the clinical impact of therapeutic drug monitoring in patients with newly diagnosed epilepsy. The Italian TDM Study Group in Epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Dizziness; Drug Administration Sched | 2000 |
The effects of carbamazepine and valproic acid on the erythrocyte glutathione, glutathione peroxidase, superoxide dismutase and serum lipid peroxidation in epileptic children.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Erythrocytes; Female; | 2000 |
Plasma and urinary serotonin and 5-HIAA in children treated with lamotrigine for intractable epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Epil | 1999 |
Erythrocyte glutathione, glutathione peroxidase, superoxide dismutase and serum lipid peroxidation in epileptic children with valproate and carbamazepine monotherapy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Erythrocytes; Female; | 2000 |
Adding valproate to lamotrigine: a study of their pharmacokinetic interaction.
Topics: Adolescent; Adult; Aged; Child; Dose-Response Relationship, Drug; Drug Costs; Drug Interactions; Dru | 2000 |
Hyperhomocysteinemia in children treated with sodium valproate and carbamazepine.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Epilepsy; Female; Homocysteine; Humans; Male; Valproic A | 2000 |
Lack of an effect of valproate concentration on lamotrigine pharmacokinetics in developmentally disabled patients with epilepsy.
Topics: Adolescent; Adult; Algorithms; Anticonvulsants; Child; Chromatography, Gas; Chromatography, High Pre | 2000 |
Influence of vitamin D administration on bone ultrasound measurements in patients on anticonvulsant therapy.
Topics: 25-Hydroxyvitamin D 2; Adult; Aged; Anticonvulsants; Bone and Bones; Calcifediol; Carbamazepine; Epi | 2000 |
Open study evaluating lamotrigine efficacy and safety in add-on treatment and consecutive monotherapy in patients with carbamazepine- or valproate-resistant epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Calcium Channel Blockers; Carbamazepine; Child; Drug Administrat | 2000 |
Epilepsy and antiepileptic drug therapy in juvenile neuronal ceroid lipofuscinosis.
Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Child; Child, Preschool; Clonazepam; Comorbidity; | 2000 |
Plasma concentration of valproate following substitution of divalproex sodium by valproic acid.
Topics: Anticonvulsants; Drug Evaluation; Epilepsy; Female; Humans; Male; Retrospective Studies; Valproic Ac | 2000 |
Can sodium valproate improve learning in children with epileptiform bursts but without clinical seizures?
Topics: Anticonvulsants; Attention; Child; Child Behavior Disorders; Cross-Over Studies; Double-Blind Method | 2000 |
Clinical study of lamotrigine and valproic acid in patients with epilepsy: using a drug interaction to advantage?
Topics: Adult; Anticonvulsants; Area Under Curve; Dose-Response Relationship, Drug; Drug Synergism; Drug The | 2000 |
Developmental and therapeutic pharmacology of antiepileptic drugs.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Admini | 2000 |
Weight change associated with valproate and lamotrigine monotherapy in patients with epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Body Weight; Child; Epilepsy; Female; Humans; Lamotrigine; | 2001 |
Renal tubular dysfunction in epileptic children on valproic acid therapy.
Topics: Acetylglucosamine; Adolescent; Anticonvulsants; beta 2-Microglobulin; Child; Cross-Sectional Studies | 2001 |
Influence of carbamazepine-10,11-epoxide on the serum level of valproic acid in epileptic patients on combined treatment with carbamazepine and valproic acid.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Intera | 2000 |
Low serum biotinidase activity in children with valproic acid monotherapy.
Topics: Amidohydrolases; Biotinidase; Child; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Liv | 2001 |
Monotherapy versus polytherapy for epilepsy: a multicenter double-blind randomized study.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Cognition Disorders; Double-Blind Method; Drug Ad | 2001 |
Randomized double-blind parallel-group study comparing cognitive effects of a low-dose lamotrigine with valproate and placebo in healthy volunteers.
Topics: Adult; Affect; Anticonvulsants; Cognition; Double-Blind Method; Epilepsy; Humans; Lamotrigine; Male; | 2002 |
[Evaluation of antiepileptic therapy during pregnancy].
Topics: Adult; Anticonvulsants; Apgar Score; Drug Therapy, Combination; Epilepsy; Female; Humans; Phenobarbi | 2002 |
Protein binding of valproic acid in Japanese pediatric and adult patients with epilepsy.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Blood Proteins; Child; Child, Preschool; Epilepsy; | 2002 |
Topiramate therapeutic monitoring in patients with epilepsy: effect of concomitant antiepileptic drugs.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Drug; Dr | 2002 |
Altered pharmacokinetics and metabolism of valproate after replacement of conventional valproate with the slow-release formulation in epileptic patients.
Topics: Adolescent; Adult; Anticonvulsants; Child; Delayed-Action Preparations; Epilepsy; Female; Gas Chroma | 2002 |
Proceedings: A controlled trial of sodium valproate in severe epilepsy.
Topics: Clinical Trials as Topic; Drug Evaluation; Epilepsy; Humans; Valerates; Valproic Acid | 1975 |
Valproic acid (Depakene). A new anticonvulsant agent.
Topics: Animals; Child; Clinical Trials as Topic; Drug Evaluation; Drug Interactions; Epilepsies, Myoclonic; | 1978 |
[Experiences with sodium 2-propyl valerate (Depakine) in the treatment of epilepsy].
Topics: Adolescent; Adult; Aged; Carbamazepine; Cerebrospinal Fluid Shunts; Child; Child, Preschool; Clinica | 1977 |
[Clinical--pharmacological aspects of treatment with sodium di-n-propylacetate].
Topics: Clinical Trials as Topic; Drug Evaluation; Epilepsy; Half-Life; In Vitro Techniques; Protein Binding | 1977 |
[Sodium di-n-propylacetate, effect in the treatment of resistant epilepsy. A controlled study].
Topics: Adolescent; Adult; Aged; Child; Clinical Trials as Topic; Drug Evaluation; Drug Resistance; Epilepsy | 1977 |
[Sodium di-n-propylacetate: evaluation of its so-called psychotropic effect. A controlled study].
Topics: Adolescent; Adult; Child; Clinical Trials as Topic; Drug Evaluation; Epilepsy; Female; Humans; Male; | 1977 |
Valproate sodium: a controlled clinical trial including monitoring of drug levels.
Topics: Adult; Child; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Drug Therapy, Combinat | 1977 |
Valproate sodium: evaluation of so-called psychotropic effect. A controlled study.
Topics: Adolescent; Adult; Clinical Trials as Topic; Clonazepam; Epilepsy; Female; Humans; Male; Mental Proc | 1977 |
[Problems in serum-level determination during valproic acid therapy].
Topics: Adolescent; Adult; Child; Clinical Trials as Topic; Drug Evaluation; Epilepsy; Female; Humans; Male; | 1977 |
[Modification of personality changes in epileptics using dipropylacetate (Convulex). Preliminary communication].
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Clinical Trials as Topic; Drug Evaluation; Epi | 1977 |
[Double-blind study on the anti-convulsive effect of phenobarbital and valproate in the Lennox syndrome].
Topics: Benzodiazepines; Child; Child, Preschool; Double-Blind Method; Drug Synergism; Drug Therapy, Combina | 1978 |
Valproic acid in epilepsy: clinical and pharmacological effects.
Topics: Adult; Binding, Competitive; Biological Availability; Blood Proteins; Clinical Trials as Topic; Drug | 1978 |
Disposition of sodium valproate in epileptic patients.
Topics: Adult; Anticonvulsants; Epilepsy; Half-Life; Humans; Kinetics; Male; Valerates; Valproic Acid | 1978 |
Sodium valproate, serum level and clinical effect in epilepsy: a controlled study.
Topics: Adolescent; Adult; Aged; Carbamazepine; Clinical Trials as Topic; Dimethadione; Dose-Response Relati | 1979 |
[Natrium valproate, antiepileptic effect--serum concentration. A controlled study].
Topics: Adolescent; Adult; Aged; Drug Evaluation; Epilepsy; Female; Humans; Male; Middle Aged; Valproic Acid | 1979 |
Sodium valproate: a review of its pharmacological properties and therapeutic efficacy in epilepsy.
Topics: Administration, Oral; Adult; Animals; Anticonvulsants; Behavior; Blood Platelets; Child; Clinical Tr | 1977 |
A double blind study of the influence of dipropylacetate on behaviour.
Topics: Adolescent; Adult; Behavior; Child; Clinical Trials as Topic; Drug Evaluation; Epilepsy; Female; Hum | 1975 |
Controlled trial of sodium valproate in severe epilepsy.
Topics: Adult; Clinical Trials as Topic; Drug Evaluation; Drug Interactions; Epilepsy; Female; Humans; Male; | 1975 |
First seizure in adults: to treat or not to treat.
Topics: Adolescent; Adult; Aged; Double-Blind Method; Drug Administration Schedule; Electroencephalography; | 1992 |
A comparative clinical and pharmacokinetic study of a new slow-release versus conventional preparations of valproic acid in children with intractable epilepsy.
Topics: Adolescent; Child; Child, Preschool; Delayed-Action Preparations; Electroencephalography; Epilepsy; | 1992 |
Coadministration of vigabatrin and valproate in children with refractory epilepsy.
Topics: 4-Aminobutyrate Transaminase; Adolescent; Aminocaproates; Anticonvulsants; Blood Platelets; Child; D | 1992 |
Conventional and controlled release valproate in children with epilepsy: a cross-over study comparing plasma levels and cognitive performances.
Topics: Adolescent; Attention; Child; Child, Preschool; Cognition; Delayed-Action Preparations; Epilepsy; Fe | 1992 |
Comparison of sprinkle versus syrup formulations of valproate for bioavailability, tolerance, and preference.
Topics: Absorption; Adolescent; Biological Availability; Chemistry, Pharmaceutical; Child; Child, Preschool; | 1992 |
Differential effects of valproic acid and enzyme-inducing anticonvulsants on nimodipine pharmacokinetics in epileptic patients.
Topics: Adult; Anticonvulsants; Drug Interactions; Enzyme Induction; Epilepsy; Female; Half-Life; Humans; Ma | 1991 |
Cognitive impairment in new cases of epilepsy randomly assigned to carbamazepine, phenytoin and sodium valproate.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cognition; Epilepsy; Humans; In | 1991 |
Valproate sodium in epilepsy. A clinical trial including monitoring of drug levels.
Topics: Adolescent; Adult; Child; Clinical Trials as Topic; Electroencephalography; Epilepsy; Female; Humans | 1990 |
A controlled study with taltrimide and sodium valproate: valproate effective in partial epilepsy.
Topics: Adolescent; Adult; Ambulatory Care; Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; F | 1990 |
Discontinuation of antiepileptic drugs in children who have outgrown epilepsy: effects on cognitive function.
Topics: Adolescent; Anticonvulsants; Attention; Carbamazepine; Child; Cognition; Epilepsy; Ethosuximide; Hum | 1990 |
[Clinical and experimental control of optimal therapy in epilepsy].
Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Humans; Neurocognitive Disorder | 1990 |
Effectiveness and plasma levels of sodium valproate monotherapy in the treatment of epilepsies in children: a further study.
Topics: Child; Dose-Response Relationship, Drug; Drug Administration Schedule; Electroencephalography; Epile | 1989 |
Serum levels of sodium valproate, phenytoin and carbamazepine and seizure control in epilepsy.
Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; Fema | 1986 |
A comparative study of progabide, valproate, and placebo as add-on therapy in patients with refractory epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Interactions; Drug | 1986 |
Valproate monotherapy in the management of generalized and partial seizures.
Topics: Clinical Trials as Topic; Epilepsies, Partial; Epilepsy; Follow-Up Studies; Humans; Remission Induct | 1987 |
Monotherapy with valproate in primary generalized epilepsies.
Topics: Adolescent; Adult; Child; Child, Preschool; Clinical Trials as Topic; Dose-Response Relationship, Dr | 1987 |
Withdrawal of anticonvulsant drugs in patients free of seizures for two years. A prospective study.
Topics: Adult; Analysis of Variance; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsies, Par | 1988 |
Effects of sodium valproate on haem biosynthesis in man: implications for seizure management in the porphyric patient.
Topics: 5-Aminolevulinate Synthetase; Adolescent; Adult; Drug Administration Schedule; Epilepsy; Female; Hem | 1988 |
Withdrawal symptoms from phenytoin, carbamazepine and sodium valproate.
Topics: Adolescent; Adult; Aged; Carbamazepine; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, | 1988 |
Which drug for the adult epileptic patient: phenytoin or valproate?
Topics: Adolescent; Adult; Aged; Body Weight; Clinical Trials as Topic; Epilepsies, Partial; Epilepsy; Femal | 1985 |
[Efficient serum concentrations after single doses of antiepileptic drugs: concept of loading-dose].
Topics: Absorption; Administration, Oral; Carbamazepine; Clinical Trials as Topic; Double-Blind Method; Epil | 1985 |
[Trial of a new antiepileptic drug, magnesium dipropyl acetate].
Topics: Adolescent; Adult; Child; Child, Preschool; Clinical Trials as Topic; Drug Evaluation; Epilepsy; Hum | 1973 |
Other Studies
2089 other studies available for valproic acid and Aura
| Article | Year |
|---|---|
Functionalized DL-amino acid derivatives. Potent new agents for the treatment of epilepsy.
Topics: Amino Acids; Animals; Anticonvulsants; Epilepsy; Magnetic Resonance Spectroscopy; Male; Mice; Seizur | 1987 |
Synthesis and evaluation of N-(phenylacetyl)trifluoromethanesulfonamides as anticonvulsant agents.
Topics: Animals; Anticonvulsants; Body Weight; Cytochrome P-450 Enzyme System; Epilepsy; Mesylates; Mice; NA | 1996 |
Alpha-fluoro-2,2,3,3-tetramethylcyclopropanecarboxamide, a novel potent anticonvulsant derivative of a cyclic analogue of valproic acid.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Cyclopropanes; Epilepsy; Male; Mice; Rats; Ra | 2009 |
Combating oxidative stress in epilepsy: design, synthesis, quantum chemical studies and anticonvulsant evaluation of 1-(substituted benzylidene/ethylidene)-4-(naphthalen-1-yl)semicarbazides.
Topics: Animals; Anticonvulsants; Antioxidants; Benzylidene Compounds; Drug Design; Electrons; Epilepsy; Mal | 2010 |
Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112).
Topics: Absorption; Amides; Animals; Anticonvulsants; Dioxanes; Dogs; Drug Evaluation, Preclinical; Drug Res | 2013 |
Design, synthesis and pharmacological evaluation of N-[4-(4-(alkyl/aryl/heteroaryl)-piperazin-1-yl)-phenyl]-carbamic acid ethyl ester derivatives as novel anticonvulsant agents.
Topics: Animals; Anticonvulsants; Carbamates; Drug Design; Electroshock; Epilepsy; Mice; Pentylenetetrazole; | 2015 |
Non-hyperammonaemia valproate-induced encephalopathy: A case report.
Topics: Anticonvulsants; Brain Diseases; Epilepsy; Female; Humans; Hyperammonemia; Middle Aged; Valproic Aci | 2022 |
Association of Therapeutic Dose of Valproic Acid and Plasma Glycine Levels in Epileptic Patients.
Topics: Anticonvulsants; Cross-Sectional Studies; Epilepsy; Glycine; Humans; Valproic Acid | 2021 |
Treatment with the combination of clavulanic acid and valproic acid led to recovery of neuronal and behavioral deficits in an epilepsy rat model.
Topics: Animals; Clavulanic Acid; Epilepsy; Kindling, Neurologic; Male; Pentylenetetrazole; Rats; Rats, Wist | 2021 |
[Women with epilepsy before and during pregnancy: a case series of outpatient counseling in a tertiary epilepsy center].
Topics: Anticonvulsants; Counseling; Epilepsy; Female; Folic Acid; Humans; Lamotrigine; Levetiracetam; Outpa | 2022 |
UK general practice: Continuing to fail in the care of people with epilepsy?
Topics: Epilepsy; Female; General Practice; Humans; Primary Health Care; United Kingdom; Valproic Acid | 2021 |
CYP2C19 & UGT1A6 genetic polymorphisms and the impact on Valproic acid-induced weight gain in people with epilepsy: Prospective genetic association study.
Topics: Anticonvulsants; Cytochrome P-450 CYP2C19; Epilepsy; Genetic Association Studies; Genotype; Glucuron | 2021 |
Evaluation of optical coherence tomography findings in adolescents with genetic generalized epilepsy.
Topics: Adolescent; Epilepsy; Epilepsy, Generalized; Humans; Retina; Tomography, Optical Coherence; Valproic | 2022 |
Valproic acid for children below 2 years of age with epilepsy.
Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Retrospective Stud | 2021 |
Successful Treatment of Symptomatic Epilepsy with Oral Valproic Acid and Levetiracetam in a Patient with Short-bowel Syndrome.
Topics: Aged; Anticonvulsants; Epilepsy; Humans; Levetiracetam; Male; Piracetam; Valproic Acid | 2022 |
GABRB3-related epilepsy: novel variants, clinical features and therapeutic implications.
Topics: Electroencephalography; Epilepsies, Myoclonic; Epilepsy; Fever; Humans; Infant; Levetiracetam; Recep | 2022 |
Effect of valproate and add-on levetiracetam on inflammatory biomarkers in children with epilepsy.
Topics: Anticonvulsants; Biomarkers; Child; Epilepsy; Humans; Levetiracetam; Neuroinflammatory Diseases; Pir | 2021 |
Pre-pregnancy counseling for women with epilepsy: Can we do better?
Topics: Anticonvulsants; Counseling; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complications; Teratogen | 2021 |
Factors Influencing Sodium Valproate Serum Concentrations in Patients with Epilepsy Based on Logistic Regression Analysis.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Child; Child, Preschool; D | 2021 |
Long-term use of valproic acid reduced mortality in bipolar disorder patients in a Taiwanese population: An association analysis using the national health insurance research database (NHIRD).
Topics: Bipolar Disorder; Epilepsy; Humans; Lithium; Male; National Health Programs; Valproic Acid | 2022 |
Correlation of GSTP1 rs1695 and CAT rs769217 with elevated AST induced by valproate sodium in Chinese children with epilepsy.
Topics: Adolescent; Anticonvulsants; Aspartate Aminotransferases; Catalase; Chemical and Drug Induced Liver | 2021 |
Interaction between valproic acid and meropenem or ertapenem in patients with epilepsy: clinical relevance and results from pharmaceutical intervention.
Topics: Aged; Anti-Bacterial Agents; Anticonvulsants; Drug Interactions; Epilepsy; Ertapenem; Humans; Male; | 2021 |
Serum folate levels in children on long-term anti-seizure medication in a Nigerian tertiary center-Implications for practice and public health.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Folic Acid; Humans; I | 2021 |
Impact of recommendations on sodium valproate prescription among women with epilepsy: An interrupted time-series study.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Infan | 2021 |
Predicting the occurrence of thrombocytopenia from free valproate levels: A prospective study.
Topics: Anticonvulsants; Epilepsy; Humans; Prospective Studies; Thrombocytopenia; Valproic Acid | 2022 |
Transgenerational adverse effects of valproate? A patient report from 90 affected families.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Cleft Lip; Cleft Palate; Drug-Related Side Ef | 2022 |
Analysis of gut microbiota in patients with epilepsy treated with valproate: Results from a three months observational prospective cohort study.
Topics: Epilepsy; Gastrointestinal Microbiome; Humans; Microbiota; Prospective Studies; Valproic Acid | 2022 |
Effect of Valproic Acid on Maternal - Fetal Heart Rates and Coupling in Mice on Embryonic day 15.5 (E15.5).
Topics: Animals; Autism Spectrum Disorder; Epilepsy; Female; Fetus; Heart Rate, Fetal; Mice; Pregnancy; Valp | 2021 |
Valproate Restrictions in Sweden and Norway: Online survey suggests implementation deficit.
Topics: Anticonvulsants; Child, Preschool; Epilepsy; Female; Humans; Norway; Pregnancy; Sweden; Valproic Aci | 2022 |
Effects of Low- and High-Dose Valproic Acid and Lamotrigine on the Heart in Female Rats.
Topics: Animals; Anticonvulsants; Epilepsy; Female; Humans; Lamotrigine; Rats; Triazines; Valproic Acid | 2022 |
Valproate prescription to women of childbearing age in English primary care: repeated cross-sectional analyses and retrospective cohort study.
Topics: Adolescent; Adult; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Cohort Studies; Contraceptio | 2022 |
Achieving neurologically desirable outcomes to pregnancy in women with epilepsy.
Topics: Anticonvulsants; Australia; Epilepsy; Female; Humans; Levetiracetam; Pregnancy; Pregnancy Complicati | 2022 |
Changes in the use of antiseizure medications in children and adolescents in Norway, 2009-2018.
Topics: Adolescent; Adult; Anticonvulsants; Child; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam; Val | 2022 |
Antiseizure medication treatment pathways for US Medicare beneficiaries with newly treated epilepsy.
Topics: Aged; Anticonvulsants; Epilepsy; Gabapentin; Humans; Lacosamide; Lamotrigine; Levetiracetam; Medicar | 2022 |
Trends in antiseizure medication prescription patterns among all adults, women, and older adults with epilepsy: A German longitudinal analysis from 2008 to 2020.
Topics: Aged; Anticonvulsants; Benzodiazepines; Carbamazepine; Drug Prescriptions; Epilepsy; Epilepsy, Gener | 2022 |
National compliance with UK wide guidelines for usage of valproate in women of childbearing potential.
Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy; Female; Humans; Infant; Pregnancy; United Kingdom; V | 2022 |
Clinical Evaluation of Levetiracetam in the Treatment of Epilepsy.
Topics: Anticonvulsants; Epilepsy; Humans; Levetiracetam; Phenytoin; Valproic Acid | 2022 |
Response to lithium and anticonvulsants among patients with bipolar disorder with and without comorbid epilepsy - A nation-wide population-based longitudinal study.
Topics: Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Comorbidity; Epilepsy; Humans; Lamotrigine; | 2022 |
Trends in the prescription of anti-seizure medicines for pregnant women outpatients with epilepsy during 2016-2020 in Japan.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Japan; Lamotrigine; Levetiracetam; Outpatients; Pregnancy | 2022 |
ARHGEF9 gene variant leads to developmental and epileptic encephalopathy: Genotypic phenotype analysis and treatment exploration.
Topics: Epilepsy; Epilepsy, Generalized; Humans; Levetiracetam; Phenotype; Retrospective Studies; Rho Guanin | 2022 |
Association of Prenatal Exposure to Antiseizure Medication With Risk of Autism and Intellectual Disability.
Topics: Anticonvulsants; Autism Spectrum Disorder; Autistic Disorder; Carbamazepine; Child; Cohort Studies; | 2022 |
Comprehensive strategy required to eliminate valproate prescribing in pregnancy.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Valproic Acid | 2022 |
[Clinical features of epilepsy in 5 children with Mowat-Wilson syndrome].
Topics: Child; Electroencephalography; Epilepsy; Facies; Female; Hirschsprung Disease; Humans; Intellectual | 2022 |
Assessment of asymmetric dimethylarginine and homocysteine in epileptic children receiving antiepileptic drugs.
Topics: Anticonvulsants; Arginine; Carotid Intima-Media Thickness; Child; Epilepsy; Homocysteine; Humans; Le | 2022 |
Seizure medication and planned pregnancy: balancing the risks and outcomes.
Topics: Anticonvulsants; Epilepsy; Family Planning Services; Female; Humans; Pregnancy; Pregnancy Complicati | 2022 |
4-Phenylbutyric Acid Plus Valproic Acid Exhibits the Therapeutic and Neuroprotective Effects in Acute Seizures Induced by Pentylenetetrazole.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Male; Neuroprotective Agents; Pentylenet | 2022 |
Differential impact of antenatal exposure to antiseizure medications on motor and mental development in infants of women with epilepsy.
Topics: Anticonvulsants; Child; Epilepsy; Female; Humans; Infant; Phenobarbital; Pregnancy; Prenatal Exposur | 2022 |
Risk factors of elevated blood ammonia level in epilepsy patients treated with lamotrigine.
Topics: Ammonia; Anticonvulsants; Epilepsy; Humans; Hyperammonemia; Lamotrigine; Risk Factors; Seizures; Tri | 2022 |
Population pharmacokinetics of oxcarbazepine 10-monohydroxy derivative in Chinese adult epileptic patients.
Topics: Adult; Anticonvulsants; Carbamazepine; East Asian People; Epilepsy; Humans; Oxcarbazepine; Polymorph | 2023 |
Dried Blood Spots as Matrix for Evaluation of Valproate Levels and the Immediate and Delayed Metabolomic Changes Induced by Single Valproate Dose Treatment.
Topics: Animals; Dried Blood Spot Testing; Epilepsy; Female; Gas Chromatography-Mass Spectrometry; Male; Met | 2022 |
Efficacy and safety of antiseizure medication in post-stroke epilepsy.
Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy; Humans; Lacosamide; Lamotrigine; Levetiracetam; Seiz | 2022 |
[Prospects for the development of new prolonged forms of valproic acid derivatives for the relief of convulsive syndrome].
Topics: Alcoholism; Anticonvulsants; Epilepsy; Humans; Seizures; Substance Withdrawal Syndrome; Valproic Aci | 2022 |
[Epilepsy in Angelman syndrome].
Topics: Angelman Syndrome; Anticonvulsants; Child; Electroencephalography; Epilepsy; Ethosuximide; Female; H | 2022 |
HYPERAMMONAEMIA AND COGNITIVE IMPAIRMENT IN EPILEPSY PATIENTS TREATED WITH VALPROIC ACID - PRELIMINARY STUDY.
Topics: Ammonia; Anticonvulsants; Cognitive Dysfunction; Dementia; Epilepsy; Female; Humans; Hyperammonemia; | 2022 |
Scaling up monitoring of risk minimization measures in women of childbearing age with anti-seizure medicines.
Topics: Anticonvulsants; Epilepsy; Europe; Female; Humans; Japan; Valproic Acid | 2022 |
Valproate Teratogenicity: A Moving Target.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complic | 2022 |
Changes in the first anti-seizure medication prescribed for children and adolescents with epilepsy in a tertiary clinical center in Serbia over two decades.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Cross-Sectional Studies; Epilepsy; Fema | 2022 |
Irritability and its relationship with psychosocial symptoms and quality of life in adolescents with epilepsy receiving levetiracetam therapy: A case-control study.
Topics: Adolescent; Anticonvulsants; Case-Control Studies; Child; Cross-Sectional Studies; Epilepsy; Humans; | 2022 |
Identification of factors associated with new-onset vascular disease in patients admitted for video-EEG monitoring: A longitudinal cohort study.
Topics: Adolescent; Adult; Child; Child, Preschool; Cohort Studies; Electroencephalography; Epilepsy; Female | 2022 |
Simultaneous determination of plasma lamotrigine, lamotrigine N2-glucuronide and lamotrigine N2-oxide by UHPLC-MS/MS in epileptic patients.
Topics: Anticonvulsants; Chromatography, High Pressure Liquid; Epilepsy; Glucuronides; Humans; Lamotrigine; | 2022 |
Investigation into Antiepileptic Effect of Ganoderic Acid A and Its Mechanism in Seizure Rats Induced by Pentylenetetrazole.
Topics: Animals; Anticonvulsants; bcl-2-Associated X Protein; Caspase 3; Epilepsy; Heptanoic Acids; Lanoster | 2022 |
Effects of antiepileptic drugs polytherapy on pregnancy outcomes in women with epilepsy: An observation study in northwest China.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam; Male; Phenobarbital; Pregnanc | 2022 |
Association between anti-seizure medication and the risk of lower urinary tract infection in patients with epilepsy.
Topics: Adult; Anti-Bacterial Agents; Anticonvulsants; Carbamazepine; Epilepsy; Female; Gabapentin; Humans; | 2022 |
Epilepsy and pregnancy. Factors associated with epileptic seizures during pregnancy.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam; Pregnancy; Seizures; V | 2023 |
Clinical and electroencephalographic features of epilepsy in patients with triple X syndrome: A case series.
Topics: Anticonvulsants; Electroencephalography; Epilepsy; Female; Humans; Levetiracetam; Retrospective Stud | 2022 |
The effect of valproic acid and furosemide on the regulation of the inflammasome complex (NLRP1 and NLRP3 mRNA) in the brain of epileptic animal model.
Topics: Animals; Brain; Disease Models, Animal; DNA-Binding Proteins; Epilepsy; Furosemide; Inflammasomes; M | 2022 |
How does foetal exposure to valproate produce adverse neurodevelopmental outcomes?
Topics: Anticonvulsants; Epilepsy; Genomics; Humans; Valproic Acid | 2022 |
Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks.
Topics: Animals; Calcium; Epilepsy; Reproducibility of Results; Seizures; Valproic Acid; Zebrafish | 2022 |
Trimetazidine, an Anti-Ischemic Drug, Reduces the Antielectroshock Effects of Certain First-Generation Antiepileptic Drugs.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease Models, Animal; Dose-Res | 2022 |
Imatinib Attenuates Pentylenetetrazole Kindled and Pilocarpine Induced Recurrent Spontaneous Seizures in Mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Imatinib Mesylate; Mice; Pentylenetetraz | 2023 |
A heterozygous missense variant in the YWHAG gene causing developmental and epileptic encephalopathy 56 in a Chinese family.
Topics: 14-3-3 Proteins; China; Epilepsy; Heterozygote; Humans; Mutation, Missense; Seizures; Valproic Acid | 2022 |
Addressing the Problem of Prescription of Valproate to Women of Childbearing Age: Reply to Tastenhoye et al.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Prescriptions; Valproic Acid | 2022 |
Impact of MDR1 and UGT Gene Polymorphisms on Sodium Valproate Plasma Concentration in Patients with Epilepsy.
Topics: Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Delayed-Action Preparation | 2022 |
Anti-seizure mechanisms of midazolam and valproate at the β2(L51M) variant of the GABA
Topics: Epilepsy; gamma-Aminobutyric Acid; Humans; Midazolam; Receptors, GABA-A; Valproic Acid | 2022 |
Efficacy of antiseizure medication in a mouse model of HCN1 developmental and epileptic encephalopathy.
Topics: Animals; Anticonvulsants; Epilepsy; Epilepsy, Generalized; Hyperpolarization-Activated Cyclic Nucleo | 2023 |
Serum folate levels in children with epilepsy seen in a tertiary health care facility in north central Nigeria.
Topics: Anticonvulsants; Carbamazepine; Child; Cross-Sectional Studies; Delivery of Health Care; Epilepsy; F | 2022 |
Insulin Resistance in children on Sodium Valproate - A hospital based cross-sectional study in Indian children.
Topics: Anticonvulsants; Child; Cross-Sectional Studies; Epilepsy; Humans; Insulin Resistance; Valproic Acid | 2023 |
Overexpression of Homer1b/c induces valproic acid resistance in epilepsy.
Topics: Animals; Anticonvulsants; Epilepsy; Mice; Pentylenetetrazole; Rats; Receptor, Metabotropic Glutamate | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
Valproic Acid-Induced Upregulation of Multidrug Efflux Transporter ABCG2/BCRP via PPAR
Topics: Anticonvulsants; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Trans | 2023 |
Valproic Acid-Induced Upregulation of Multidrug Efflux Transporter ABCG2/BCRP via PPAR
Topics: Anticonvulsants; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Trans | 2023 |
Valproic Acid-Induced Upregulation of Multidrug Efflux Transporter ABCG2/BCRP via PPAR
Topics: Anticonvulsants; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Trans | 2023 |
Valproic Acid-Induced Upregulation of Multidrug Efflux Transporter ABCG2/BCRP via PPAR
Topics: Anticonvulsants; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Trans | 2023 |
Valproic Acid-Induced Upregulation of Multidrug Efflux Transporter ABCG2/BCRP via PPAR
Topics: Anticonvulsants; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Trans | 2023 |
Valproic Acid-Induced Upregulation of Multidrug Efflux Transporter ABCG2/BCRP via PPAR
Topics: Anticonvulsants; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Trans | 2023 |
Valproic Acid-Induced Upregulation of Multidrug Efflux Transporter ABCG2/BCRP via PPAR
Topics: Anticonvulsants; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Trans | 2023 |
Valproic Acid-Induced Upregulation of Multidrug Efflux Transporter ABCG2/BCRP via PPAR
Topics: Anticonvulsants; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Trans | 2023 |
Valproic Acid-Induced Upregulation of Multidrug Efflux Transporter ABCG2/BCRP via PPAR
Topics: Anticonvulsants; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Trans | 2023 |
Supply problems of antiseizure medication are common among epilepsy patients in Germany.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Germany; Humans; Medication Adherence; Valproic Acid | 2023 |
Supply problems of antiseizure medication are common among epilepsy patients in Germany.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Germany; Humans; Medication Adherence; Valproic Acid | 2023 |
Supply problems of antiseizure medication are common among epilepsy patients in Germany.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Germany; Humans; Medication Adherence; Valproic Acid | 2023 |
Supply problems of antiseizure medication are common among epilepsy patients in Germany.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Germany; Humans; Medication Adherence; Valproic Acid | 2023 |
Supply problems of antiseizure medication are common among epilepsy patients in Germany.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Germany; Humans; Medication Adherence; Valproic Acid | 2023 |
Supply problems of antiseizure medication are common among epilepsy patients in Germany.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Germany; Humans; Medication Adherence; Valproic Acid | 2023 |
Supply problems of antiseizure medication are common among epilepsy patients in Germany.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Germany; Humans; Medication Adherence; Valproic Acid | 2023 |
Supply problems of antiseizure medication are common among epilepsy patients in Germany.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Germany; Humans; Medication Adherence; Valproic Acid | 2023 |
Supply problems of antiseizure medication are common among epilepsy patients in Germany.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Germany; Humans; Medication Adherence; Valproic Acid | 2023 |
Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Benzodiazepines; Carbamazepine; Cohort Studies; Epilep | 2023 |
Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Benzodiazepines; Carbamazepine; Cohort Studies; Epilep | 2023 |
Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Benzodiazepines; Carbamazepine; Cohort Studies; Epilep | 2023 |
Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Benzodiazepines; Carbamazepine; Cohort Studies; Epilep | 2023 |
Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Benzodiazepines; Carbamazepine; Cohort Studies; Epilep | 2023 |
Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Benzodiazepines; Carbamazepine; Cohort Studies; Epilep | 2023 |
Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Benzodiazepines; Carbamazepine; Cohort Studies; Epilep | 2023 |
Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Benzodiazepines; Carbamazepine; Cohort Studies; Epilep | 2023 |
Comparative Safety of Antiseizure Medication Monotherapy for Major Malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Benzodiazepines; Carbamazepine; Cohort Studies; Epilep | 2023 |
Valproic acid-induced hyperammonemia in neuropsychiatric disorders: a 2-year clinical survey.
Topics: Ammonia; Anticonvulsants; Epilepsy; Humans; Hyperammonemia; Risperidone; Valproic Acid | 2023 |
Valproic acid-induced hyperammonemia in neuropsychiatric disorders: a 2-year clinical survey.
Topics: Ammonia; Anticonvulsants; Epilepsy; Humans; Hyperammonemia; Risperidone; Valproic Acid | 2023 |
Valproic acid-induced hyperammonemia in neuropsychiatric disorders: a 2-year clinical survey.
Topics: Ammonia; Anticonvulsants; Epilepsy; Humans; Hyperammonemia; Risperidone; Valproic Acid | 2023 |
Valproic acid-induced hyperammonemia in neuropsychiatric disorders: a 2-year clinical survey.
Topics: Ammonia; Anticonvulsants; Epilepsy; Humans; Hyperammonemia; Risperidone; Valproic Acid | 2023 |
Effect of valproate on sleep patterns disturbed by epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Quality of Life; Rat | 2023 |
Effect of valproate on sleep patterns disturbed by epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Quality of Life; Rat | 2023 |
Effect of valproate on sleep patterns disturbed by epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Quality of Life; Rat | 2023 |
Effect of valproate on sleep patterns disturbed by epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Quality of Life; Rat | 2023 |
Determination of valproic acid and its six metabolites in human serum using LC-MS/MS and application to interaction with carbapenems in epileptic patients.
Topics: Anticonvulsants; Carbapenems; Chromatography, Liquid; Epilepsy; Humans; Tandem Mass Spectrometry; Va | 2023 |
Determination of valproic acid and its six metabolites in human serum using LC-MS/MS and application to interaction with carbapenems in epileptic patients.
Topics: Anticonvulsants; Carbapenems; Chromatography, Liquid; Epilepsy; Humans; Tandem Mass Spectrometry; Va | 2023 |
Determination of valproic acid and its six metabolites in human serum using LC-MS/MS and application to interaction with carbapenems in epileptic patients.
Topics: Anticonvulsants; Carbapenems; Chromatography, Liquid; Epilepsy; Humans; Tandem Mass Spectrometry; Va | 2023 |
Determination of valproic acid and its six metabolites in human serum using LC-MS/MS and application to interaction with carbapenems in epileptic patients.
Topics: Anticonvulsants; Carbapenems; Chromatography, Liquid; Epilepsy; Humans; Tandem Mass Spectrometry; Va | 2023 |
Trends in antiseizure medications utilization among women of childbearing age with epilepsy in Poland between 2015 and 2019.
Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Epilepsy; Female; Humans; Lamotrigine; Levetiraceta | 2023 |
Novel SYN1 Variant in Two Brothers with Focal Epilepsy and Their Prompt Response to Valproate.
Topics: Epilepsies, Partial; Epilepsy; Humans; Male; Mammals; Siblings; Synapsins; Valproic Acid | 2023 |
Maintaining equity and reducing risk when prescribing valproate: we still have a way to go.
Topics: Anticonvulsants; Epilepsy; Humans; Valproic Acid | 2023 |
Effects of
Topics: Anticonvulsants; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; East Asian People; Epilepsy; Gen | 2023 |
Impact of regulatory restrictions on the use of valproic acid in women of childbearing age: An Italian study.
Topics: Anticonvulsants; Drug Prescriptions; Epilepsy; Female; Humans; Italy; Valproic Acid | 2023 |
The Effect of Adenosine Signaling on Memory Impairment Induced by Pentylenetetrazole in Zebrafish.
Topics: Adenosine; Animals; Dipyridamole; Epilepsy; Pentylenetetrazole; Quality of Life; Seizures; Valproic | 2023 |
[A severe, reversible encephalopathy after prolonged use of valproic acid].
Topics: Aged; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Brain Diseases; Epilepsy; Female; Hum | 2023 |
Long-term outcomes of classic and novel anti-seizure medication in a kainate-induced model of chronic epilepsy.
Topics: Animals; Anticonvulsants; Carbamazepine; Epilepsy; Epilepsy, Temporal Lobe; Kainic Acid; Mice; Valpr | 2023 |
Effects of dosage in new users of lamotrigine inducing epidermal necrolysis: Results of the German Registry of Severe Skin Reactions.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Lamotrigine; Male; Registries; Stevens-Johnson Syn | 2023 |
Current treatment options for familial adult myoclonus epilepsy.
Topics: Adult; Anticonvulsants; Epilepsies, Myoclonic; Epilepsy; Humans; Myoclonus; Tremor; Valproic Acid | 2023 |
Efficacy and mechanisms of Dingxian pill combined with valproic acid on pentylenetetrazol-induced chronic epilepsy in rats.
Topics: Animals; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Seizures; Valproic Acid | 2023 |
Prescribed antiseizure medication doses and their relation to defined daily doses for achieving seizure freedom in newly diagnosed patients with epilepsy.
Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Epilepsy; Freedom; Humans; Oxcarbazepine; Retrospec | 2023 |
Survey on the management of childhood epilepsy among general practitioners in the area of Marrakech.
Topics: Child; Cross-Sectional Studies; Epilepsy; General Practitioners; Humans; Surveys and Questionnaires; | 2023 |
Analysing patient-generated data to understand behaviours and characteristics of women with epilepsy of childbearing years: A prospective cohort study.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Death, Sudden; Epilepsy; Female; Humans; Middle Aged; Pros | 2023 |
Prenatal Exposure to Antiseizure Medication and Incidence of Childhood- and Adolescence-Onset Psychiatric Disorders.
Topics: Adolescent; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Carbamazepine; Child; Ch | 2023 |
A novel method for predicting the unbound valproic acid concentration.
Topics: Anticonvulsants; Epilepsy; Humans; Renal Insufficiency; Retrospective Studies; Valproic Acid | 2023 |
Selection and Continuation of Antiseizure Medication in Children With Epilepsy in Sweden From 2007 to 2020.
Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Lamotrigine; Levetiracet | 2023 |
Arginase deficiency-An unheralded cause of developmental epileptic encephalopathy.
Topics: Child; Epilepsy; Epilepsy, Generalized; Humans; Hyperammonemia; Hyperargininemia; Valproic Acid | 2023 |
Valproate-related hyperammonemic encephalopathy with generalized suppression EEG: a case report.
Topics: Adult; Anticonvulsants; Brain Diseases; Electroencephalography; Epilepsy; Female; Humans; Hyperammon | 2023 |
The effect of anti-seizure medications on lipid values in adults with epilepsy.
Topics: Adult; Epilepsy; Humans; Hypercholesterolemia; Valproic Acid | 2023 |
Acute pancreatitis during valproic acid administration in a patient with vascular dementia, epileptic seizures, and psychiatric symptoms: a case report.
Topics: Acute Disease; Aged; Amylases; Anticonvulsants; Dementia, Vascular; Epilepsy; Humans; Male; Pancreat | 2023 |
Risk of recurrence in patients with an unprovoked tonic-clonic seizure and generalized epileptiform discharges on EEG.
Topics: Adult; Electroencephalography; Epilepsy; Humans; Prospective Studies; Recurrence; Seizures; Valproic | 2023 |
Adverse Event Profiles of Antiseizure Medications and the Impact of Coadministration on Drug Tolerability in Adults with Epilepsy.
Topics: Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anticonvulsants; Epilepsy; Humans; | 2023 |
Prescribing Trends of Antiseizure Drugs in Women Veterans With Epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Gabapentin; Humans; Lamotrigine; Levetiracetam | 2023 |
Change in Apo B100/A1 Ratio in Children With Epilepsy on Monotherapy With Sodium Valproate, Oxcarbazepine or Levetiracetam.
Topics: Anticonvulsants; Carbamazepine; Child; Epilepsy; Humans; Levetiracetam; Longitudinal Studies; Oxcarb | 2023 |
Bearing variant alleles at uridine glucuronosyltransferase polymorphisms UGT2B7 -161C > T (rs7668258) or UGT1A4*3 c.142 T > G (rs2011425) has no relevant consequences for lamotrigine troughs in adults with epilepsy.
Topics: Adult; Alleles; Anticonvulsants; Bayes Theorem; Epilepsy; Genotype; Glucuronosyltransferase; Humans; | 2023 |
Birth outcomes in pregnant women with epilepsy: A Nationwide multicenter study from Türkiye.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant; Infant, Newborn; Lamotrigine; Preg | 2023 |
Utilization of Antiseizure Medications in Women of Childbearing Age With Epilepsy and Nonepilepsy Indications: A Retrospective Cohort Study.
Topics: Anticonvulsants; Clonazepam; Diazepam; Epilepsy; Female; Gabapentin; Humans; Lamotrigine; Lorazepam; | 2023 |
SCN1A Polymorphisms and Haplotypes Are Associated With Valproic Acid Treatment Outcomes in Chinese Children With Epilepsy.
Topics: Anticonvulsants; Child; East Asian People; Epilepsy; Genotype; Haplotypes; Humans; NAV1.1 Voltage-Ga | 2023 |
Prescribing of valproate and oral antiepileptics for women of childbearing age and during pregnancy in Germany between 2010 and 2020.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Germany; Humans; Middle Aged; Pregnancy; Presc | 2023 |
Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo.
Topics: Anticonvulsants; Endocrine Disruptors; Epilepsy; Female; Fetus; Humans; Male; Testis; Valproic Acid | 2023 |
Valproate induced carnitine deficiency and hyperammonaemia.
Topics: Amino Acid Metabolism, Inborn Errors; Anticonvulsants; Carnitine; Epilepsy; Humans; Hyperammonemia; | 2023 |
Valproate associated brain volume-loss in pediatric epilepsy-A case series.
Topics: Aged, 80 and over; Brain; Child; Epilepsy; Gray Matter; Humans; Valproic Acid; White Matter | 2023 |
Epilepsy and long-term risk of arrhythmias.
Topics: Atrial Fibrillation; Carbamazepine; Epilepsy; Genetic Predisposition to Disease; Humans; Valproic Ac | 2023 |
[Safe and Effective Management of Epilepsy in Pregnancy].
Topics: Anticonvulsants; Epilepsy; Female; Humans; Levetiracetam; Pregnancy; Seizures; Valproic Acid | 2023 |
Potassium Channel Subfamily T Member 1(KCNT1) Pathological Variant Causing Epilepsy Of Infancy With Migrating Focal Seizures: A Case Report.
Topics: Cyanosis; Epilepsy; Humans; Infant; Male; Nerve Tissue Proteins; Potassium Channels; Potassium Chann | 2023 |
The prevalence and risk factors of coagulopathy in pediatric patients undergoing surgery for epilepsy.
Topics: Afibrinogenemia; Anticonvulsants; Blood Coagulation Disorders; Body Weight; Child; Epilepsy; Humans; | 2023 |
The impact of a newly established specialized pediatric epilepsy center in Tanzania: An observational study.
Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Epilepsy; Humans; Phenobarbital; Tanzania; V | 2023 |
Effect of digoxin, sodium valproate, and celecoxib on the cerebral cyclooxygenase pathway and neuron-specific enolase under the pentylenetetrazole-induced kindling in mice.
Topics: Animals; Anticonvulsants; Celecoxib; Digoxin; Epilepsy; Mice; Neuroinflammatory Diseases; Pentylenet | 2023 |
Cerebral and cerebellar pseudoatrophy associated with valproic acid. Report of three pediatric cases.
Topics: Anticonvulsants; Brain; Brain Diseases; Cerebellum; Child; Child, Preschool; Epilepsy; Humans; Neuro | 2023 |
Impact of
Topics: Case-Control Studies; Cytochrome P-450 CYP2C9; Drug-Related Side Effects and Adverse Reactions; Epil | 2023 |
Distribution pattern of UGT1A6 and UGT2B7 gene polymorphism and its impact on the pharmacokinetics of valproic acid and carbamazepine: Prospective genetic association study conducted in Pakistani patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Epilepsy; Glucuronosyltransferase; Humans; | 2024 |
Changes over 24 years in a pregnancy register - Teratogenicity and epileptic seizure control.
Topics: Anticonvulsants; Australia; Epilepsy; Female; Humans; Lamotrigine; Pregnancy; Pregnancy Complication | 2023 |
Real-world practices for the care of women with epilepsy during pregnancy: A Canadian perspective.
Topics: Adult; Anticonvulsants; Canada; Epilepsy; Epilepsy, Generalized; Female; Humans; Pregnancy; Pregnanc | 2023 |
Validity of Serum Zinc/Copper Ratio as a Potential Novel Biomarker in Childhood Epilepsy.
Topics: Anticonvulsants; Biomarkers; Child; Copper; Epilepsy; Humans; Levetiracetam; Oxcarbazepine; Valproic | 2023 |
The Valproic Acid Dilemma: Safe Alternatives For Pregnant Women And Women Of Childbearing Age With Epilepsy.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Pregnant Women; Valproic Acid | 2023 |
Reducing birth defects in women with epilepsy: Research leading to results.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Valproic Acid | 2019 |
Efficacy of phenobarbital and sodium valproate in treating convulsive epilepsy in rural northeast China.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; China; Epilepsy; Female; Follow-Up Stud | 2019 |
Did advice on the prescription of sodium valproate reduce prescriptions to women? An observational study in three European countries between 2007 and 2016.
Topics: Adolescent; Adult; Anticonvulsants; Bipolar Disorder; Child; Cohort Studies; Databases, Factual; Epi | 2019 |
Exome sequencing in patients with antiepileptic drug exposure and complex phenotypes.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child; Child, Preschool; Developmental Disabilities; E | 2020 |
Elevated serum alkaline phosphatase in epilepsy: effect of age and treatment.
Topics: Adolescent; Adult; Age Factors; Alkaline Phosphatase; Anticonvulsants; Carbamazepine; Child; Child, | 2020 |
N-Benzyl-(2,5-dioxopyrrolidin-1-yl)propanamide (AS-1) with Hybrid Structure as a Candidate for a Broad-Spectrum Antiepileptic Drug.
Topics: Animals; Anticonvulsants; Behavior, Animal; Dose-Response Relationship, Drug; Epilepsy; Ethosuximide | 2020 |
Intestinal inflammation increases convulsant activity and reduces antiepileptic drug efficacy in a mouse model of epilepsy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Colitis; Convulsants; Dextran Sul | 2019 |
[Epilepsy in children with congenital hemiparesis secondary to perinatal ictus].
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Infan | 2019 |
Determination of unbound valproic acid in plasma using centrifugal ultrafiltration and gas chromatography:Application in TDM.
Topics: Adolescent; Child; Child, Preschool; Chromatography, Gas; Drug Monitoring; Epilepsy; Female; Humans; | 2020 |
Perampanel-induced hair curling in a patient with epilepsy associated with Pitt Hopkins syndrome.
Topics: Adolescent; Anticonvulsants; Epilepsy; Facies; Female; Hair; Humans; Hyperventilation; Intellectual | 2019 |
Prevalence of valproate prescriptions in women of childbearing age in certain regions of Russia.
Topics: Adolescent; Adult; Anticonvulsants; Cross-Sectional Studies; Drug Prescriptions; Epilepsy; Female; H | 2019 |
A serious adverse drug reaction probably induced by clonazepam: a case report of myotoxicity.
Topics: Adult; Anticonvulsants; Clonazepam; Drug Therapy, Combination; Epilepsy; Female; Humans; Myotoxicity | 2019 |
Prevalence and risk factors for hyponatremia in adult epilepsy patients: Large-scale cross-sectional cohort study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Antipsychotic Agents; Benzodiazepines; | 2019 |
Evaluation of sodium valproate loaded nanoparticles in acute and chronic pentylenetetrazole induced seizure models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Maze Learning; Oxidative Stress; Pentyle | 2019 |
Cognitive performances in patients affected by late-onset epilepsy with unknown etiology: A 12-month follow-up study.
Topics: Age of Onset; Aged; Aged, 80 and over; Anticonvulsants; Cognition; Epilepsy; Female; Follow-Up Studi | 2019 |
De novo Absence Status Epilepticus in a pediatric cohort: Electroclinical pattern in a multicenter Italian patients cohort.
Topics: Adolescent; Anticonvulsants; Child; Electroencephalography; Epilepsy; Ethosuximide; Female; Humans; | 2019 |
The role of isoaspartate in fibrillation and its prevention by Protein-L-isoaspartyl methyltransferase.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Anticonvulsants; Aspartic Acid; Benzothi | 2020 |
Effects of valproic acid and levetiracetam monotherapy on carotid intima-media and epicardial adipose tissue thickness in non-obese children with epilepsy.
Topics: Adipose Tissue; Anticonvulsants; Atherosclerosis; Body Mass Index; Carotid Arteries; Carotid Intima- | 2020 |
Language impairment in children aged 5 and 8 years after antiepileptic drug exposure in utero - the Norwegian Mother and Child Cohort Study.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cohort Studies; Epilepsy; Female; Humans; L | 2020 |
Dried Blood Microsampling-Based Therapeutic Drug Monitoring of Antiepileptic Drugs in Children With Nodding Syndrome and Epilepsy in Uganda and the Democratic Republic of the Congo.
Topics: Anticonvulsants; Carbamazepine; Child; Chromatography, Liquid; Democratic Republic of the Congo; Dri | 2020 |
[Confusional migraine in a young adult female: Is it a subtype of migraine with aura?]
Topics: Adult; Epilepsy; Female; Humans; Migraine Disorders; Topiramate; Valproic Acid; Young Adult | 2020 |
Treatment decisions in women of childbearing age on valproate.
Topics: Adult; Anticonvulsants; Decision Making; Epilepsy; Female; Humans; Informed Consent; Patient Educati | 2020 |
Exploring the ameliorative role of α7 neuronal nicotinic acetylcholine receptor modulation in epilepsy and associated comorbidities in post-PTZ-kindled mice.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Anticonvulsants; Corticosterone; Depression; Dose- | 2020 |
Evaluation of Cardiac Repolarization Indices in Epilepsy Patients Treated with Carbamazepine and Valproic Acid.
Topics: Adolescent; Adult; Carbamazepine; Cross-Sectional Studies; Electrocardiography; Epilepsy; Female; He | 2020 |
ATP1A3-related epilepsy: Report of seven cases and literature-based analysis of treatment response.
Topics: Adult; Anticonvulsants; Cerebellar Ataxia; Child; Dystonic Disorders; Epilepsy; Female; Hearing Loss | 2020 |
Downregulation of peripheral PTGS2/COX-2 in response to valproate treatment in patients with epilepsy.
Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Cyclooxygenase | 2020 |
Valproic acid associated pleuropericardial effusion: case report.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Pericardial Effusion; Pleural Effusion; Valproic Acid; Yo | 2020 |
Valproate risk form-Surveying 215 clinicians involving 4775 encounters.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam; Physicians | 2020 |
Effects of Sodium Valproate Combined with Lamotrigine on Quality of Life and Serum Inflammatory Factors in Patients with Poststroke Secondary Epilepsy.
Topics: Aged; Anticonvulsants; Biomarkers; Brain; Case-Control Studies; Down-Regulation; Drug Therapy, Combi | 2020 |
Impact of Age and Genotype on Serum Concentrations of Valproic Acid and Its Hepatotoxic Metabolites in Chinese Pediatric Patients With Epilepsy.
Topics: Adolescent; Anticonvulsants; Asian People; Child; Child, Preschool; Epilepsy; Female; Genotype; Gluc | 2020 |
Evaluation of adverse drug reaction profile of antiepileptic drugs in persons with epilepsy: A cross-sectional study.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Child; Cross-Sectional Studies; Drug-Related Si | 2020 |
Testing association of rare genetic variants with resistance to three common antiseizure medications.
Topics: Anticonvulsants; Case-Control Studies; Drug Resistance; Epilepsy; Female; Genotype; Humans; Lamotrig | 2020 |
Analysis of antiseizure drug-related adverse reactions from the electronic health record using the common data model.
Topics: Anticonvulsants; Common Data Elements; Drug-Related Side Effects and Adverse Reactions; Electronic H | 2020 |
Association of SCN1A, SCN2A, and UGT2B7 Polymorphisms with Responsiveness to Valproic Acid in the Treatment of Epilepsy.
Topics: Adult; Asian People; Epilepsy; Female; Genotype; Glucuronosyltransferase; Humans; Male; NAV1.1 Volta | 2020 |
Vaccination management in an asymptomatic child with a novel SCN1A variant and family history of status epilepticus following vaccination: A case report on a potential new direction in personalised medicine.
Topics: Anticonvulsants; Clobazam; Enterovirus A, Human; Enterovirus Infections; Epilepsy; Fatal Outcome; Fe | 2020 |
Effects of carbamazepine, eslicarbazepine, valproic acid and levetiracetam on bone microarchitecture in rats.
Topics: Animals; Anticonvulsants; Bone and Bones; Carbamazepine; Dibenzazepines; Disease Models, Animal; Epi | 2020 |
Evolution of Epileptiform Activity in Zebrafish by Statistical-Based Integration of Electrophysiology and 2-Photon Ca
Topics: Action Potentials; Animals; Calcium; Electrophysiological Phenomena; Epilepsy; Female; Humans; Male; | 2020 |
Improvement of epilepsy with lacosamide in a patient with ring chromosome 20 syndrome.
Topics: Anticonvulsants; Carbamazepine; Child; Electroencephalography; Epilepsy; Humans; Lacosamide; Lamotri | 2020 |
Influence of age and co-medication on the concentration and efficacy of valproic acid in Chinese epilepsy children.
Topics: Adolescent; Age Factors; Anticonvulsants; Asian People; Child; Child, Preschool; Drug Therapy, Combi | 2020 |
Impact of the EMA/FDA alerts on the use of effective contraceptive method in women of childbearing age undergoing valproic acid treatment in a long-stay psychiatric center.
Topics: Adult; Anticonvulsants; Contraception; Drug and Narcotic Control; Drug Labeling; Epilepsy; Europe; F | 2020 |
Pregnancy after valproate withdrawal-Fetal malformations and seizure control.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Australia; Epilepsy; Female; Humans; Pregnancy; | 2020 |
Rufinamide as add-on therapy in children with epileptic encephalopathies other than Lennox-Gastaut syndrome: A study of 34 patients.
Topics: Adolescent; Anticonvulsants; Argentina; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy | 2020 |
Serum Levels of Valproic Acid and Carbamazepine Do Not Correlate Well with End-Organ Dysfunction.
Topics: Adolescent; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Child, Preschool; Drug Therapy, | 2020 |
Reply to Calabrò: Towards a better understanding of valproate induced sexual and reproductive dysfunction in men with epilepsy.
Topics: Anticonvulsants; Epilepsy; Humans; Male; Sexual Behavior; Sexual Health; Valproic Acid | 2020 |
Effects of valproate, carbamazepine and levetiracetam on Tp-e interval, Tp-e/QT and Tp-e/QTc ratio.
Topics: Adult; Anticonvulsants; Arrhythmias, Cardiac; Carbamazepine; Case-Control Studies; Electrocardiograp | 2020 |
Treating women of reproductive age with valproate.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Valproic Acid | 2020 |
The impact and challenges of the 2018 MHRA statement on the use of sodium valproate in women of childbearing age during the first year of implementation, in a UK epilepsy centre.
Topics: Adolescent; Adult; Anticonvulsants; Contraception; Contraindications, Drug; Cross-Sectional Studies; | 2020 |
Effects of Diclofenac Versus Meloxicam in Pentylenetetrazol-Kindled Mice.
Topics: Animals; Anticonvulsants; Diclofenac; Epilepsy; Kindling, Neurologic; Male; Meloxicam; Mice; Pentyle | 2020 |
Towards a better understanding of valproate-induced sexual and reproductive dysfunction in men with epilepsy.
Topics: Anticonvulsants; Epilepsy; Humans; Male; Sexual Behavior; Sexual Health; Valproic Acid | 2020 |
Association Between the Serum Carnitine Level and Ammonia and Valproic Acid Levels in Patients with Bipolar Disorder.
Topics: Ammonia; Anticonvulsants; Bipolar Disorder; Carnitine; Epilepsy; Female; Humans; Male; Middle Aged; | 2020 |
Autophagy associated with the efficacy of valproic acid in PTZ-induced epileptic rats.
Topics: Animals; Anticonvulsants; Autophagy; Convulsants; Drug Resistance; Epilepsy; Male; Pentylenetetrazol | 2020 |
Sub-additive (antagonistic) interaction of lacosamide with lamotrigine and valproate in the maximal electroshock-induced seizure model in mice: an isobolographic analysis.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Drug | 2020 |
Effects of antiepileptic drugs on electroencephalography (EEG): Insights and applicability.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Carbamazepine; Electroencephalography; Epilepsy | 2020 |
Dosing Recommendations Based on Population Pharmacokinetics of Lamotrigine in Mexican Adult Patients With Epilepsy.
Topics: Adult; Anticonvulsants; Epilepsy; Humans; Lamotrigine; Triazines; Valproic Acid | 2020 |
What about children treated with valproate?
Topics: Anticonvulsants; Child; Epilepsy; Humans; Valproic Acid | 2020 |
Pharmacokinetic Variability During Long-Term Therapeutic Drug Monitoring of Valproate, Clobazam, and Levetiracetam in Patients With Dravet Syndrome.
Topics: Adolescent; Adult; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Dioxolanes; | 2020 |
Is the Medicines and Healthcare products Regulator Agency (MHRA) guidance on sodium valproate acceptable to women of childbearing age?
Topics: Anticonvulsants; Delivery of Health Care; Epilepsy; Female; Government Agencies; Humans; Pregnancy; | 2020 |
Factors associated with depression in people with epilepsy: a retrospective case-control analysis.
Topics: Adult; Anticonvulsants; Case-Control Studies; Clonazepam; Depression; Epilepsy; Female; Humans; Male | 2020 |
Thrombocytopenia in pediatric patients on concurrent cannabidiol and valproic acid.
Topics: Adolescent; Anticonvulsants; Cannabidiol; Child; Child, Preschool; Drug Resistant Epilepsy; Drug The | 2020 |
Remedial dosing recommendations for delayed or missed doses of valproic acid in patients with epilepsy based on Monte Carlo simulations.
Topics: Adult; Aged; Anticonvulsants; Child; Child, Preschool; Drug Administration Schedule; Epilepsy; Femal | 2020 |
Valproic acid and zonisamide induced hyperammonemic encephalopathy.
Topics: Adult; Anticonvulsants; Brain; Brain Diseases; Epilepsy; Humans; Hyperammonemia; Magnetic Resonance | 2020 |
SLC6A1 G443D associated with developmental delay and epilepsy.
Topics: Child, Preschool; Developmental Disabilities; Epilepsy; Female; GABA Plasma Membrane Transport Prote | 2020 |
Antiepileptic combination therapy with Stevens-Johnson syndrome and toxic epidermal necrolysis: Analysis of a Japanese pharmacovigilance database.
Topics: Anticonvulsants; Carbamazepine; Clobazam; Clonazepam; Databases, Factual; Drug Therapy, Combination; | 2020 |
Sleep Architecture in Valproate-Induced Nocturnal Enuresis in Primary School and Preschool Children.
Topics: Age Factors; Arousal; Brain; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Nocturnal Enur | 2020 |
Metabolic syndrome and obstructive sleep apnea syndrome among patients with epilepsy on monotherapy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Cross-Sectional Studies; Epilepsy; Female; | 2020 |
[Dynamics of epileptiform activity, efficacy and tolerability of valproic acid in adults and adolescents with newly-diagnosed epilepsy].
Topics: Adolescent; Adult; Anticonvulsants; Electroencephalography; Epilepsies, Partial; Epilepsy; Epilepsy, | 2020 |
Valproate prescribing practices for women with intellectual disability across Europe.
Topics: Adolescent; Adult; Anticonvulsants; Drug Prescriptions; Epilepsy; Europe; Female; Humans; Intellectu | 2021 |
Understanding and Responding to Prescribing Patterns of Sodium Valproate-Containing Medicines in Pregnant Women and Women of Childbearing Age in Western Cape, South Africa.
Topics: Epilepsy; Female; Humans; Practice Patterns, Physicians'; Pregnancy; Pregnant Women; South Africa; V | 2021 |
Impact of CYP2C19 and CYP2C9 gene polymorphisms on sodium valproate plasma concentration in patients with epilepsy.
Topics: Aryl Hydrocarbon Hydroxylases; China; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Epilepsy; H | 2022 |
Safety range of free valproic acid serum concentration in adult patients.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Dosage Forms; Dose-Response Relationship, Drug; Dru | 2020 |
Valproic acid concentration and biochemical indexes in epilepsy outpatients during monotherapy or combination therapy.
Topics: Adolescent; Anticonvulsants; Combined Modality Therapy; Drug Therapy, Combination; Epilepsy; Humans; | 2020 |
Trends of anti-seizure medication use in pediatric patients in six cities in China from 2013 to 2018.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; China; Epilepsy; Female; Humans | 2020 |
Risk-benefit assessment of treatment of epileptic women of childbearing age with valproic acid.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Humans; Middle Aged; Pregnancy; Risk Assessmen | 2020 |
First do no harm: valproate and medicines safety in pregnancy.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complications; Valproic Acid | 2020 |
Topics: Anticonvulsants; Carbamazepine; Cytochrome P-450 CYP3A; Epilepsy; Humans; Malaysia; Valproic Acid | 2021 |
Risk of early neurodevelopmental disorders associated with in utero exposure to valproate and other antiepileptic drugs: a nationwide cohort study in France.
Topics: Adult; Anticonvulsants; Child, Preschool; Cohort Studies; Dose-Response Relationship, Drug; Epilepsy | 2020 |
Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children.
Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Genotype; Humans; Male; NAV1.1 Voltage-G | 2020 |
Ex vivo radiosensitivity is increased in non-cancer patients taking valproate.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Cells, Cultured; Cohort Studies; Epilepsy; Female; | 2020 |
Antiseizure medication use during pregnancy and risk of ASD and ADHD in children.
Topics: Adolescent; Adult; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Autism Spectrum D | 2020 |
Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Intellectual Disability and Delayed Childhood Milestones.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Denmark; Developmen | 2020 |
Clinical and Kinematic Features of Valproate-Induced Tremor and Differences with Essential Tremor.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Biomechanical Phenomena; Diagnosis, Differential; E | 2021 |
Effects of valproate, lamotrigine, and levetiracetam monotherapy on bone health in newly diagnosed adult patients with epilepsy.
Topics: Adult; Anticonvulsants; Bone Density; Epilepsy; Humans; Lamotrigine; Levetiracetam; Triazines; Valpr | 2020 |
The correlation between carbamazepine and valproic acid monotherapy with serum adiponectin and carnitine.
Topics: Adiponectin; Adult; Anticonvulsants; Biomarkers; Carbamazepine; Carnitine; Dose-Response Relationshi | 2021 |
Evaluation of the Protective Effect of Ademetionine, Cytoflavin, and Dihydroquercetetine on Blood Enzymes Activity in Rats Treated with High Doses of Sodium Valproate.
Topics: Alkaline Phosphatase; Animals; Anticonvulsants; Drug Combinations; Epilepsy; Erythrocytes; Flavin Mo | 2020 |
Metformin, valproic acid, and starvation induce seizures in a patient with partial SLC13A5 deficiency: a case of pharmaco-synergistic heterozygosity.
Topics: Adult; Amino Acid Substitution; Ammonia; Animals; Anticonvulsants; Autistic Disorder; Bipolar Disord | 2021 |
Determination of healthcare resource and cost implications of using alternative sodium valproate formulations in the treatment of epilepsy in children in England: A retrospective database review.
Topics: Administrative Claims, Healthcare; Adolescent; Child; Child, Preschool; Cost Savings; Datasets as To | 2021 |
An open study of valproate in subfertile men with epilepsy.
Topics: Adult; Anticonvulsants; Drug Substitution; Epilepsy; Female; Greece; Humans; Infertility, Male; Lamo | 2020 |
Real-world prescribing trends of valproate in women with epilepsy in Korea.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Republic of Korea; Valproic Acid | 2021 |
Population pharmacokinetics of unbound valproic acid in pediatric epilepsy patients in China: a protein binding model.
Topics: Adolescent; Anticonvulsants; Body Weight; Child; Child, Preschool; China; Drug Dosage Calculations; | 2021 |
Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats.
Topics: Adjuvants, Pharmaceutic; Animals; Anticonvulsants; Behavior, Animal; Centella; Cognitive Dysfunction | 2021 |
Acute and chronic treatment with moclobemide, a reversible MAO-inhibitor, potentiates the antielectroshock activity of conventional antiepileptic drugs in mice.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, | 2021 |
Valproic acid and socioeconomic associations in Swedish women with epilepsy 2010-2015.
Topics: Adolescent; Adult; Anticonvulsants; Cohort Studies; Drug Prescriptions; Educational Status; Epilepsy | 2021 |
Prenatal valproate exposure and adverse neurodevelopmental outcomes: Does sex matter?
Topics: Anticonvulsants; Autism Spectrum Disorder; Case-Control Studies; Child; Child, Preschool; Dose-Respo | 2021 |
Knowledge of epilepsy among German pharmacists.
Topics: Anticonvulsants; Carbamazepine; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Humans; L | 2021 |
The effects of valproate on serum leptin, insulin, and lipid levels in epileptic children.
Topics: Anticonvulsants; Child; Epilepsy; Humans; Insulin; Leptin; Valproic Acid | 2021 |
Thinking out of the box: management of valproic acid toxicity with carbapenems.
Topics: Adult; Anticonvulsants; Carbapenems; Carnitine; Epilepsy; Female; Humans; Meropenem; Valproic Acid | 2021 |
Carnitine supplementation prevents carnitine deficiency caused by pivalate-conjugated antibiotics in patients with epilepsy prescribed valproate.
Topics: Anti-Bacterial Agents; Carnitine; Dietary Supplements; Epilepsy; Humans; Valproic Acid | 2021 |
Epigenetic evidence of an Ac/Dc axis by VPA and SAHA.
Topics: Acetylation; Cells, Cultured; Epigenesis, Genetic; Epilepsy; Gene Expression Regulation; Histone Dea | 2021 |
Valproate usage in pregnancy: An audit from the Kerala Registry of Epilepsy and Pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Epilepsy; Female; Humans; India; Pregnancy; Pre | 2021 |
Effects of antiepileptic drugs' administration during pregnancy on the nerve cell proliferation and axonal outgrowth of human neuroblastoma SH-SY5Y nerve cells.
Topics: Anticonvulsants; Carbamazepine; Cell Line, Tumor; Cell Proliferation; Child; Epilepsy; Female; Human | 2021 |
Response to first antiseizure medication in patients diagnosed with epilepsy.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Cohort Studies; Epilepsy; Female; Follow-Up Studies; Hu | 2021 |
The contribution of non-drug factors to fetal malformation in anti-seizure-medication-treated pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Australia; Epilepsy; Female; Humans; Pregnancy; | 2021 |
Valproate but not levetiracetam slows the EEG alpha peak frequency - A pharmaco-EEG study.
Topics: Adolescent; Adult; Aged; Alpha Rhythm; Anticonvulsants; Brain; Child; Electroencephalography; Epilep | 2021 |
Effects of antiseizure monotherapy on visuospatial memory in pediatric age.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Ethosuximide; Executive Function; Femal | 2021 |
Predictors of successful valproate withdrawal in women with epilepsy.
Topics: Anticonvulsants; Epilepsy; Epilepsy, Generalized; Female; Humans; Levetiracetam; Valproic Acid | 2021 |
Valproic acid use in fertile women with genetic generalized epilepsies.
Topics: Anticonvulsants; Epilepsy; Epilepsy, Generalized; Female; Humans; Infant, Newborn; Male; Retrospecti | 2021 |
Influence of
Topics: Anticonvulsants; Child; China; Epilepsy; Glucuronosyltransferase; Humans; Polymorphism, Single Nucle | 2021 |
Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children: A protocol for systematic review and meta-analysis.
Topics: Anticonvulsants; Child; Drug Resistance; Electroencephalography; Epilepsy; Humans; Meta-Analysis as | 2021 |
Post-stroke epilepsy and antiepileptic drug use in men and women.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Lamotrigin | 2021 |
Treatment effects of the combination of ceftriaxone and valproic acid on neuronal and behavioural functions in a rat model of epilepsy.
Topics: Animals; Ceftriaxone; Epilepsy; Male; Neurons; Rats; Rats, Wistar; Valproic Acid | 2021 |
Contemporary trends in antiepileptic drug treatment among women of childbearing age with epilepsy in the United States: 2004-2015.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Pregnancy | 2021 |
CNKSR2 gene mutation leads to Houge type of X-linked syndromic mental retardation: A case report and review of literature.
Topics: Adaptor Proteins, Signal Transducing; Anticonvulsants; Child; Codon, Nonsense; Epilepsy; Humans; Int | 2021 |
Association of UGT1A6 gene polymorphism with clinical outcome in pediatric epileptic patients on sodium valproate monotherapy.
Topics: Anticonvulsants; Child; Epilepsy; Humans; Polymorphism, Single Nucleotide; Seizures; Valproic Acid | 2021 |
Histopathological and Biochemical Assessment of Neuroprotective Effects of Sodium Valproate and Lutein on the Pilocarpine Albino Rat Model of Epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Humans; Lutein; Neuroprotective Agents; | 2021 |
Factors associated with blood carnitine levels in adult epilepsy patients with chronic valproic acid therapy.
Topics: Adult; Amino Acids; Anticonvulsants; Carnitine; Epilepsy; Humans; Valproic Acid | 2021 |
Epileptic convulsions probably induced by desloratadine: a case report.
Topics: Anticonvulsants; Child; Epilepsy; Humans; Male; Seizures; Valproic Acid | 2023 |
Post-stroke seizures: risk factors and management after ischemic stroke.
Topics: Aged; Epilepsy; Female; Humans; Infarction, Middle Cerebral Artery; Ischemic Stroke; Male; Middle Ag | 2023 |
Plasma brain natriuretic peptide levels in children with idiopathic epilepsy treated with longterm sodium valproate and oxcarbazepine monotherapy.
Topics: Anticonvulsants; Child; Epilepsy; Humans; Natriuretic Peptide, Brain; Oxcarbazepine; Valproic Acid | 2021 |
A Comparative Study of the Effects of Valproate and Oxcarbazepine on Sexual Function, Sperm Quality, and Sex Hormones in Males with Epilepsy.
Topics: Adult; Case-Control Studies; Epilepsy; Gonadal Steroid Hormones; Humans; Male; Oxcarbazepine; Sperma | 2021 |
Management of bone metabolism in epilepsy.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Male; Retrospective Studies; Valproic Acid | 2021 |
Effects of l-carnitine supplementation in patients with childhood-onset epilepsy prescribed valproate.
Topics: Carnitine; Child; Dietary Supplements; Epilepsy; Humans; Retrospective Studies; Valproic Acid | 2021 |
The Relationship Between Valproate and Lamotrigine/Levetiracetam Use and Prognosis in Patients With Epilepsy and Heart Failure: A Danish Register-Based Study.
Topics: Aged; Anticonvulsants; Cohort Studies; Denmark; Epilepsy; Heart Failure; Humans; Lamotrigine; Leveti | 2022 |
Association of CYP2C9, CYP2A6, ACSM2A, and CPT1A gene polymorphisms with adverse effects of valproic acid in Chinese patients with epilepsy.
Topics: Anticonvulsants; Asian People; Carnitine O-Palmitoyltransferase; Coenzyme A Ligases; Cytochrome P-45 | 2017 |
Influence of age and co-medication on the steady-state pharmacokinetics of valproic acid in Tunisian patients with epilepsy.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Child, Preschool; Drug Interactions; Drug Mo | 2017 |
Assessment of atherosclerotic risk among patients with epilepsy on valproic acid, lamotrigine, and carbamazepine treatment.
Topics: Adult; Anticonvulsants; Carbamazepine; Cholesterol; Cross-Sectional Studies; Epilepsy; Female; Human | 2017 |
Monitoring Protein-Unbound Valproic Acid Serum Concentrations in Clinical Practice.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Blood Proteins; Child; Drug Monitoring; | 2017 |
A Long-Term Treatment with Arachidonyl-2'-Chloroethylamide Combined with Valproate Increases Neurogenesis in a Mouse Pilocarpine Model of Epilepsy.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Astrocytes; Disease Models, Animal; Drug Therapy, Combi | 2017 |
The remarkable story of valproic acid.
Topics: Anticonvulsants; Epilepsy; History, 20th Century; Humans; Valproic Acid | 2016 |
Population Pharmacokinetics of Valproic Acid in Patients with Mania: Implication for Individualized Dosing Regimens.
Topics: Adolescent; Adult; Aged; Antimanic Agents; Bipolar Disorder; Body Weight; Drug Monitoring; Epilepsy; | 2017 |
Contraception advice for women with epilepsy.
Topics: Adult; Contraception Behavior; Contraceptive Agents; Counseling; Drug Interactions; Epilepsy; Family | 2017 |
Burst Suppression Pattern on Electroencephalogram Secondary to Valproic Acid-Induced Hyperammonemic Encephalopathy.
Topics: Adolescent; Anticonvulsants; Autistic Disorder; Brain Diseases; Electroencephalography; Epilepsy; Fe | 2017 |
Clinical Importance of Monitoring Unbound Valproic Acid Concentration in Patients with Hypoalbuminemia.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Drug Monitoring; Epilepsy; Female; Humans; Hypoalbu | 2017 |
The influence of levetiracetam on psychosocial and behavioral functioning in children: A case-control and follow-up study.
Topics: Adolescent; Anticonvulsants; Case-Control Studies; Child; Child Behavior; Epilepsy; Female; Follow-U | 2017 |
Patterns of antiepileptic drug prescription in Sweden: A register-based approach.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Drug Prescriptions; Epilepsy; Female; Humans; Lamotrigi | 2017 |
Analysis of the Variables Influencing Valproic Acid Concentration in the Serum and Cerebrospinal Fluid of Chinese Patients After Craniotomy.
Topics: Aged; Asian People; Craniotomy; Cytochrome P-450 CYP2C9; Epilepsy; Female; Humans; Male; Middle Aged | 2017 |
Effect of ketogenic diet and other dietary therapies on anti-epileptic drug concentrations in patients with epilepsy.
Topics: Adolescent; Anticonvulsants; Biological Availability; Child; Child, Preschool; Diet, Ketogenic; Dose | 2017 |
The impact of valproic acid treatment on weight gain in pediatric patients with epilepsy.
Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Seizures; Valproic Acid; W | 2022 |
Inattention and Poor Eye Contact Is Not All Autism.
Topics: Anticonvulsants; Autism Spectrum Disorder; Child; Diagnosis, Differential; Electroencephalography; E | 2017 |
N-alkyl-[1,1'-biphenyl]-2-sulfonamide derivatives as novel broad spectrum anti-epileptic drugs with efficacy equivalent to that of sodium valproate.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Mice; | 2017 |
Genetic polymorphisms and valproic acid plasma concentration in children with epilepsy on valproic acid monotherapy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Glucuronosyltransferase; Hum | 2017 |
Clinical study on anti-epileptic drug with B vitamins for the treatment of epilepsy after stroke.
Topics: Adult; Aged; Anticonvulsants; Epilepsy; Female; Humans; Male; Middle Aged; Stroke; Valproic Acid; Vi | 2017 |
Thrombotic microangiopathy associated with Valproic acid toxicity.
Topics: Adolescent; Anticonvulsants; Epilepsy; Humans; Male; Thrombotic Microangiopathies; Valproic Acid | 2017 |
Pharmacokinetic variability of valproate in women of childbearing age.
Topics: Adolescent; Adult; Anticonvulsants; Drug Monitoring; Epilepsy; Female; Humans; Middle Aged; Norway; | 2017 |
Risk factors for sodium valproate-induced renal tubular dysfunction.
Topics: Adolescent; Adult; Anticonvulsants; beta 2-Microglobulin; Biomarkers; Carnitine; Chi-Square Distribu | 2018 |
Pharmacokinetic and pharmacodynamic interaction of hydroalcoholic extract of Ocimum sanctum with valproate.
Topics: Animals; Anticonvulsants; Antioxidants; Avoidance Learning; Cognition; Disease Models, Animal; Drug | 2017 |
Melatonin and Hippo Pathway: Is There Existing Cross-Talk?
Topics: Animals; Antioxidants; Circadian Rhythm; Epilepsy; Humans; Melatonin; Protein Serine-Threonine Kinas | 2017 |
Decreased platelet count in children with epilepsy treated with valproate and its relationship to the immature platelet fraction.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Flow Cytometry; Humans; Infa | 2018 |
[Bone metabolism disorders caused by sodium valproate therapy in children with epilepsy and the prevention of the disorders by supplementation of calcium and vitamin D].
Topics: Adolescent; Anticonvulsants; Bone and Bones; Calcium; Calcium, Dietary; Child; Child, Preschool; Die | 2017 |
Women still not being told about pregnancy risks of valproate.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Developmental Disabilities; Epilepsy; Female; Humans; | 2017 |
Correlations between UGT2B7∗2 gene polymorphisms and plasma concentrations of carbamazepine and valproic acid in epilepsy patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Child; Child, Preschool; | 2018 |
Effects of Carbamazepine and Valproate on Serum Aspartate Aminotransferase, Alanine Aminotransferase and Gamma - Glutamyltransferase in Children.
Topics: Adolescent; Alanine Transaminase; Anticonvulsants; Aspartate Aminotransferases; Carbamazepine; Child | 2017 |
Two gaps too many, three clues too few? Do elevated osmolal and anion gaps with crystalluria always mean ethylene glycol poisoning?
Topics: Acid-Base Equilibrium; Acidosis; Anticonvulsants; Brain Diseases; Calcium Oxalate; Cognitive Dysfunc | 2017 |
Fetal Valproate Syndrome - Still a Problem Today!
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Cesarean Section; Drug Therapy, Combination; Ep | 2017 |
Sotalol enhances the anticonvulsant action of valproate and diphenylhydantoin in the mouse maximal electroshock model.
Topics: Animals; Anti-Arrhythmia Agents; Anticonvulsants; Avoidance Learning; Brain; Disease Models, Animal; | 2017 |
A rapid and simple HPLC-MS/MS method for the simultaneous quantification of valproic acid and its five metabolites in human plasma and application to study pharmacokinetic interaction in Chinese epilepsy patients.
Topics: Adolescent; Adult; Anticonvulsants; Asian People; Chromatography, High Pressure Liquid; Drug Interac | 2018 |
Influence of valproate on language functions in children with epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Cognition; Dose-Response Relationship, Drug; D | 2018 |
Vitamin D deficiency in children with epilepsy taking valproate and levetiracetam as monotherapy.
Topics: Adolescent; Child; Cross-Sectional Studies; Epilepsy; Female; Humans; Levetiracetam; Male; Prevalenc | 2018 |
Does Valproic Acid/Na Valproate Suppress Auditory Startle Reflex in Patients With Epilepsy?
Topics: Acoustic Stimulation; Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Humans; Male; Middle Age | 2018 |
Marked efficacy of combined three-drug therapy (Sodium Valproate, Topiramate and Stiripentol) in a patient with Dravet syndrome.
Topics: Anticonvulsants; Child, Preschool; Dioxolanes; Drug Therapy, Combination; Epilepsies, Myoclonic; Epi | 2018 |
Evaluation of sex hormones and sperm parameters in male epileptic patients.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Gonadal Steroid Hormones; Gonadotropins | 2018 |
Population pharmacokinetics of lamotrigine co-administered with valproic acid in Chinese epileptic children using nonlinear mixed effects modeling.
Topics: Adolescent; Anticonvulsants; Asian People; Child; Child, Preschool; Drug Therapy, Combination; Epile | 2018 |
Subtherapeutic valproic acid plasma concentrations under concomitant dipyrone therapy in an epilepsy patient-a case report.
Topics: Aged; Analgesics; Anticonvulsants; Dipyrone; Epilepsy; Humans; Male; Valproic Acid | 2018 |
Women with epilepsy in childbearing age: Pregnancy-related knowledge, information sources, and antiepileptic drugs.
Topics: Adolescent; Adult; Anticonvulsants; Counseling; Croatia; Epilepsy; Female; Health Knowledge, Attitud | 2018 |
Micronization potentiates curcumin's anti-seizure effect and brings an important advance in epilepsy treatment.
Topics: Animals; Anticonvulsants; Biological Availability; Curcumin; Disease Models, Animal; Drug Compoundin | 2018 |
Utilization of Antiepileptic Medicines in Swedish Children and Adolescents with Different Diagnoses.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Prescriptions; Drug Utilization; Epilepsy | 2018 |
Safety of antiepileptic drugs in children and young people: A prospective cohort study.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Chi-Square Distribution; Child; Child, Preschool; Cohort | 2018 |
Vitamin D Deficiency in Ambulant Children on Carbamazepine or Sodium Valproate Monotherapy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Case-Control Studies; Child; Child, Preschool; Cross-Sec | 2018 |
Pharmacokinetic variability of valproate during pregnancy - Implications for the use of therapeutic drug monitoring.
Topics: Adult; Anticonvulsants; Dose-Response Relationship, Drug; Drug Monitoring; Epilepsy; Female; Humans; | 2018 |
Antiepileptic Drugs in Pregnancy-Quick Decisions With Long-term Consequences.
Topics: Anticonvulsants; Child; Epilepsy; Female; Humans; Language; Mathematics; Pregnancy; Pregnancy Compli | 2018 |
Outcomes of pregnancies in women taking antiepileptic drugs for non-epilepsy indications.
Topics: Abnormalities, Drug-Induced; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Outcome Ass | 2018 |
Valproate-induced Hyperammonemic Encephalopathy Presenting as Catatonia.
Topics: Adult; Anticonvulsants; Brain Diseases; Catatonia; Epilepsy; Female; Humans; Hyperammonemia; Valproi | 2018 |
Effect of antiepileptic drug comedication on lamotrigine concentrations.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Inte | 2018 |
A Cross-Sectional Study to Assess the Modulation of Wnt Inhibitors following Anti-Epileptic Drug Therapy and their Correlation with Vitamin D and Receptor Activator of Nuclear Factor κ B Ligand in Indian Women with Epilepsy.
Topics: Adaptor Proteins, Signal Transducing; Adult; Anticonvulsants; Bone Morphogenetic Proteins; Carbamaze | 2018 |
Declining trend in valproate use in Finland among females of childbearing age in 2012-2016 - a nationwide registry-based outpatient study.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Finland; Humans; Male; Outpatients; Registries | 2018 |
Observational multicentre study into the use of antiepileptic drugs in Spanish neurology consultations.
Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Female; Humans; Lamotrigine; Levetirace | 2020 |
A population pharmacokinetic model taking into account protein binding for the sustained-release granule formulation of valproic acid in children with epilepsy.
Topics: Adolescent; Anticonvulsants; Body Weight; Child; Child, Preschool; Delayed-Action Preparations; Epil | 2018 |
Reader response: Expression of Concern: Does compensatory hyperparathyroidism predispose to ischemic stroke? Decreased bone mass and increased bone turnover with valproate therapy in adults with epilepsy; An alternative to vitamin D supplementation to pre
Topics: Adult; Bone Density; Bone Remodeling; Brain Ischemia; Dietary Supplements; Epilepsy; Humans; Hyperpa | 2018 |
[A nationwide multi-center questionnaire survey on the management and treatment of post-stroke seizure and epilepsy in Japan].
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Japan; Levetiracetam; Male; Piracetam; Sei | 2018 |
Carnitine Deficiency in Chinese Children with Epilepsy on Valproate Monotherapy.
Topics: Anticonvulsants; Beijing; Carnitine; Case-Control Studies; Child, Preschool; Deficiency Diseases; Ep | 2018 |
Weighing the risks of valproate in women who could become pregnant.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Contraindications, Drug; Developmental Disabilities; E | 2018 |
Dangers of valproate in pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complic | 2018 |
Sodium valproate-induced Fanconi syndrome in two severely disabled patients receiving carnitine supplementation.
Topics: Adult; Anticonvulsants; Carnitine; Disabled Persons; Epilepsy; Fanconi Syndrome; Female; Humans; Int | 2019 |
The effects of valproate and topiramate use on serum insulin, leptin, neuropeptide Y and ghrelin levels in epileptic children.
Topics: Adolescent; Anticonvulsants; Biomarkers; Blood Glucose; Body Mass Index; Child; Epilepsy; Fructose; | 2018 |
Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug | 2018 |
Valproate and epilepsy: for women as well as men.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Male; Sex Factors; Valproic Acid | 2018 |
Carbamazepine Verses Valproic Acid as Monotherapy in Epileptic Patients.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Chromatography, Liquid; Epilepsy; Female; | 2018 |
ABCC2 rs2273697 is associated with valproic acid concentrations in patients with epilepsy on valproic acid monotherapy.
Topics: Adult; Anticonvulsants; Asian People; Epilepsy; Female; Genotype; Humans; Male; Multidrug Resistance | 2018 |
Prevalence of valproate syndrome in Europe from 2005 to 2014: A registry based multi-centre study.
Topics: Adult; Anticonvulsants; Cognitive Dysfunction; Congenital Abnormalities; Epilepsy; Europe; Female; H | 2018 |
Evaluation ofserum free carnitine/acylcarnitine levels and left ventricular systolic functions in children with idiopathic epilepsy receiving valproic acid.
Topics: Adolescent; Anticonvulsants; Biomarkers; Carnitine; Child; Child, Preschool; Electrocardiography; Ep | 2018 |
The preconception care experiences of women with epilepsy on sodium valproate.
Topics: Adolescent; Adult; Anticonvulsants; Decision Making; Drug Substitution; Epilepsy; Female; Health Beh | 2018 |
Interaction between ABCG2 421C>A polymorphism and valproate in their effects on steady-state disposition of lamotrigine in adults with epilepsy.
Topics: Adolescent; Adult; Aged; Alleles; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; AT | 2018 |
Risk Factors for Valproic Acid-induced Hyperammonaemia in Chinese Paediatric Patients with Epilepsy.
Topics: Age Factors; Ammonia; Anticonvulsants; Aspartate Aminotransferases; Chemical and Drug Induced Liver | 2018 |
Guidance is needed on valproate in pregnancy for those without capacity.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Valproic Acid | 2018 |
Prescribing in pregnancy shows the weaknesses in pharmacovigilance.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Pharmacovigilance; Pregnancy; Pregnancy Complications; Va | 2018 |
[Establish and use of an epilepsy model in larval zebrafish].
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Epilepsy; Larva; Nerve Tissue Proteins; Pen | 2016 |
Childhood Visual Hallucinations: A Case Report of Idiopathic Occipital Epilepsy.
Topics: Child; Electroencephalography; Epilepsy; Female; Hallucinations; Humans; Occipital Lobe; Psychiatric | 2018 |
Teaching NeuroImages: Dyke-Davidoff-Masson syndrome.
Topics: Anticonvulsants; Cerebral Cortex; Epilepsy; Humans; Magnetic Resonance Imaging; Male; Middle Aged; V | 2018 |
Effect of valproic acid on perampanel pharmacokinetics in patients with epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Cytochrome P-450 Enzyme Inducers; Cytochrome P-450 | 2018 |
Obstetric outcomes and effects on babies born to women treated for epilepsy during pregnancy in a resource limited setting: a comparative cohort study.
Topics: Abortion, Spontaneous; Adolescent; Adult; Anticonvulsants; Body Height; Body Weight; Carbamazepine; | 2018 |
Biochemical derangements related to metabolic syndrome in epileptic patients on treatment with valproic acid.
Topics: Adolescent; Adult; Anticonvulsants; Biomarkers; Body Mass Index; Cholesterol; Cross-Sectional Studie | 2018 |
Reducing valproate use in women with epilepsy.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Drug Utilization; Epilepsy; Female; | 2018 |
[Prescribing valproate to girls and women of childbearing age in Germany : Analysis of trends based on claims data].
Topics: Adult; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Drug Prescriptions; Drug Utilization; Ep | 2018 |
Nonlesional late-onset epilepsy: Semiology, EEG, cerebrospinal fluid, and seizure outcome characteristics.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Electroencephalography; Epilepsy; Femal | 2019 |
Memory dysfunction in school-aged children exposed prenatally to antiepileptic drugs.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Dose-Response Relationship, Drug; Epilepsy; Female; Hu | 2018 |
Population pharmacokinetics of valproic acid in epileptic children: Effects of clinical and genetic factors.
Topics: Adolescent; Anticonvulsants; Asian People; ATP-Binding Cassette Transporters; Child; Child, Preschoo | 2018 |
Polymorphisms of peroxisome proliferator-activated receptor γ (PPARγ) and cluster of differentiation 36 (CD36) associated with valproate-induced obesity in epileptic patients.
Topics: Adolescent; Adult; Alleles; Anticonvulsants; Asian People; Body Mass Index; Body Weight; CD36 Antige | 2018 |
Valproate free serum concentrations: More complex than simple formulas.
Topics: Anticonvulsants; Epilepsy; Humans; Prospective Studies; Valproic Acid | 2018 |
Renal dysfunctions/injury in adult epilepsy patients treated with carbamazepine or valproate.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Creatinine; Cross-Sectional Studies; Epilepsy; Fe | 2018 |
Levetiracetam and lamotrigine effects as mono- and polytherapy on bone mineral density in epileptic patients.
Topics: Adolescent; Adult; Amino Acids; Anticonvulsants; Biomarkers; Bone Density; Bone Remodeling; Case-Con | 2018 |
Valproate-associated foetal malformations-Rates of occurrence, risks in attempted avoidance.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Australia; Epilepsy; Female; Humans; Pregnancy; | 2019 |
Evaluation of ghrelin, nesfatin-1 and irisin levels of serum and brain after acute or chronic pentylenetetrazole administrations in rats using sodium valproate.
Topics: Animals; Anticonvulsants; Biomarkers; Brain; Calcium-Binding Proteins; Disease Models, Animal; DNA-B | 2018 |
New regulations to cut valproate-exposed pregnancies.
Topics: Anticonvulsants; Epilepsy; Female; Government Regulation; Humans; Pregnancy; Pregnancy Complications | 2018 |
Diacylglycerol kinase (DGKA) regulates the effect of the epilepsy and bipolar disorder treatment valproic acid in
Topics: Amino Acid Sequence; Anticonvulsants; Bipolar Disorder; Diacylglycerol Kinase; Dictyostelium; Diglyc | 2018 |
Valproate, women, and exceptional circumstances.
Topics: Anticonvulsants; Drug Prescriptions; Drug Utilization; Epilepsy; Female; Humans; Pregnancy; Teratoge | 2018 |
A Population Pharmacokinetic-Pharmacogenetic Model of Lamotrigine in Chinese Children With Epilepsy.
Topics: Anticonvulsants; Asian People; ATP-Binding Cassette Transporters; Child; Drug Interactions; Epilepsy | 2018 |
Variants p.Q1236H and p.E1143G in mitochondrial DNA polymerase gamma POLG1 are not associated with increased risk for valproate-induced hepatotoxicity or pancreatic toxicity: A retrospective cohort study of patients with epilepsy.
Topics: Adolescent; Adult; Alanine Transaminase; Anticonvulsants; Aspartate Aminotransferases; Chemical and | 2018 |
Sodium valproate: who knew what and when? Cumulative meta-analysis gives extra insights.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Meta-Analysis as Topic; Preg | 2019 |
Sodium valproate correcting hypernatremia of diabetes insipidus-a fortunate incident.
Topics: Adult; Diabetes Insipidus, Neurogenic; Epilepsy; Humans; Hypernatremia; Male; Valproic Acid | 2018 |
Severe hyperammonaemic encephalopathy resulting from the overlap between hepatic and valproate encephalopathy.
Topics: Alcoholism; Brain Diseases; Epilepsy; Humans; Hyperammonemia; Hypertension, Portal; Male; Middle Age | 2018 |
Vitamin D status in children with epilepsy treated with levetiracetam monotherapy.
Topics: Child; Epilepsy; Humans; Levetiracetam; Piracetam; Valproic Acid; Vitamin D; Vitamin D Deficiency | 2018 |
Catalase C-262T Polymorphism Is a Risk Factor for Valproic Acid-Induced Abnormal Liver Function in Chinese Patients With Epilepsy.
Topics: Adolescent; Anticonvulsants; Asian People; Catalase; Chemical and Drug Induced Liver Injury; Child; | 2019 |
Long-Term Safety, Tolerability, and Efficacy of Cannabidiol in Children with Refractory Epilepsy: Results from an Expanded Access Program in the US.
Topics: Adolescent; Anticonvulsants; Cannabidiol; Child; Child, Preschool; Drug Therapy, Combination; Epilep | 2019 |
Valproate-Induced Polycystic Ovary Syndrome in a Girl with Epilepsy: A Case Study.
Topics: Adolescent; Biomarkers; Epilepsy; Female; Humans; Luteinizing Hormone; Magnetic Resonance Imaging; P | 2018 |
[Valproate sodium (and its derivatives) and risk of teratogenicity].
Topics: Anticonvulsants; Epilepsy; Humans; Valproic Acid | 2017 |
Perinatal outcome and healthcare resource utilization in the first year of life after antiepileptic exposure during pregnancy.
Topics: Adult; Anticonvulsants; Databases, Factual; Epilepsy; Female; Health Resources; Humans; Infant; Infa | 2019 |
Trends in valproate use in patients in Germany between 2009 and 2017.
Topics: Adolescent; Adult; Anticonvulsants; Cross-Sectional Studies; Drug Prescriptions; Epilepsy; Female; G | 2019 |
Adverse drug reactions associated with six commonly used antiepileptic drugs in southern China from 2003 to 2015.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Child; Child, Preschool; China; Epileps | 2019 |
The influence of concomitant antiepileptic drugs on lamotrigine serum concentrations in Northwest Chinese Han population with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Asian People; Carbamazepine; Child; Child, Preschool; China; Dru | 2019 |
Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Risk for Attention-Deficit/Hyperactivity Disorder in Offspring.
Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Child; Cohort Studies; Denmark; Epil | 2019 |
Fetal antiepileptic drug exposure and learning and memory functioning at 6 years of age: The NEAD prospective observational study.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Humans; Lamotrigine; Learning; Memor | 2019 |
Valproic acid-induced nocturnal enuresis in pediatric patients.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Headache; Humans; Incidence; | 2019 |
Energy Drink-Induced Breakthrough Seizure in a Patient on Valproic Acid-Considering Herbal Safety in Epilepsy.
Topics: Adolescent; Anticonvulsants; Energy Drinks; Epilepsy; Herb-Drug Interactions; Humans; Male; Seizures | 2019 |
Preliminary evidence about irritability in patients with epilepsy treated by perampanel as first add-on therapy compared to levetiracetam and valproic acid.
Topics: Adult; Anticonvulsants; Anxiety; Drug Therapy, Combination; Epilepsy; Female; Humans; Irritable Mood | 2019 |
Lamotrigine drug interactions in combination therapy and the influence of therapeutic drug monitoring on clinical outcomes in paediatric patients.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Czech Republic; Dose-Response R | 2019 |
SCN1A and SCN2A polymorphisms are associated with response to valproic acid in Chinese epilepsy patients.
Topics: Adolescent; Adult; Anticonvulsants; Asian People; Child; Child, Preschool; Epilepsy; Female; Genetic | 2019 |
AMPA receptor antagonist perampanel affects glioblastoma cell growth and glutamate release in vitro.
Topics: Anticonvulsants; Antineoplastic Agents; Apoptosis; Brain; Brain Neoplasms; Cell Line, Tumor; Cell Pr | 2019 |
Valproate is contraindicated in pregnancy.
Topics: Anticonvulsants; Contraindications, Drug; Epilepsy; Female; Humans; Neurodevelopmental Disorders; Pr | 2019 |
The clinical characteristics and related factors of tremor in patients with epilepsy.
Topics: Activities of Daily Living; Adult; Anticonvulsants; Case-Control Studies; Drug-Related Side Effects | 2019 |
Serum carnitine levels of children with epilepsy: Related factors including valproate.
Topics: Adolescent; Body Mass Index; Carnitine; Child; Child, Preschool; Cognitive Dysfunction; Epilepsy; Fe | 2019 |
Level of empowerment and decision-making style of women with epilepsy in childbirth age.
Topics: Adolescent; Adult; Anticonvulsants; Decision Making; Empowerment; Epilepsy; Female; Humans; Middle A | 2019 |
Developmental outcomes at age four following maternal antiepileptic drug use.
Topics: Adult; Anticonvulsants; Carbamazepine; Child Development; Child, Preschool; Cohort Studies; Epilepsy | 2019 |
Effects of Sodium Valproate, Levetiracetam and Phenytoin Therapy on Evoked Potentials in Children with Epilepsy.
Topics: Adolescent; Child; Child, Preschool; Cross-Sectional Studies; Epilepsy; Evoked Potentials; Humans; L | 2019 |
Valproate under threat.
Topics: Anticonvulsants; Epilepsy; Europe; Female; Humans; Valproic Acid | 2019 |
Adverse Drug Reactions of Anti-Epileptic Drugs in Children with Epilepsy: A Cross-Sectional Study.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Cross-Sectional Studies; Epilepsy; Female; Hum | 2019 |
Effects of levetiracetam and valproic acid treatment on liver function tests, plasma free carnitine and lipid peroxidation in childhood epilepsies.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Anticonvulsants; Carnitine; Child; Deoxyguanosine; Epilepsy; Female; Hu | 2019 |
Correlation of MCT1 and ABCC2 gene polymorphisms with valproic acid resistance in patients with epilepsy on valproic acid monotherapy.
Topics: Adult; Anticonvulsants; Drug Resistance; Epilepsy; Female; Genotype; Humans; Male; Monocarboxylic Ac | 2019 |
Changes in Serum Valproate and Levetiracetam Levels Related to Sex Steroids in Adolescent Girls.
Topics: Adolescent; Anticonvulsants; Child; Epilepsy; Estradiol; Female; Humans; Levetiracetam; Menstrual Cy | 2019 |
Valproate and the Pregnancy Prevention Programme.
Topics: Epilepsy; Female; Humans; Pregnancy; Pregnancy Complications; Valproic Acid | 2019 |
Valproic acid concentrations in nursing mothers, mature milk, and breastfed infants in monotherapy and combination therapy.
Topics: Adult; Animals; Anticonvulsants; Breast Feeding; Drug Therapy, Combination; Epilepsy; Female; Humans | 2019 |
Etiology of neonatal seizures and maintenance therapy use: a 10-year retrospective study at Toulouse Children's hospital.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Cohort Studies; Databases, Factual; Dose-Response Relati | 2019 |
The effect of co-administration of pentylenetetrazole with pilocarpine: New modified PTZ models of kindling and seizure.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Drug Resistance; Epilepsy; Kindling, | 2019 |
Potential biomarker of fibroblast growth factor 21 in valproic acid-treated livers.
Topics: Adult; Animals; Anticonvulsants; Biomarkers; Case-Control Studies; Chemical and Drug Induced Liver I | 2019 |
Attenuation of retinal nerve fibre layer in people with epilepsy receiving valproate.
Topics: Adolescent; Adult; Case-Control Studies; Epilepsy; Female; Humans; Male; Nerve Fibers; Retinal Neuro | 2019 |
Lipidomic characteristics and clinical findings of epileptic patients treated with valproic acid.
Topics: Anticonvulsants; Biomarkers; Dyslipidemias; Epilepsy; Female; Humans; Lipid Metabolism; Lipidomics; | 2019 |
Behavioral problems in children of mothers with epilepsy prenatally exposed to valproate, carbamazepine, lamotrigine, or levetiracetam monotherapy.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Child Behavior Disorders; Epilepsy; Female; Humans; La | 2019 |
Management and attitudes toward patients with epilepsy in general practice: How far have we come in three decades?
Topics: Adult; Anticonvulsants; Attitude of Health Personnel; Australia; Carbamazepine; Clinical Competence; | 2019 |
Valproic acid potently inhibits interictal-like epileptiform activity in prefrontal cortex pyramidal neurons.
Topics: Animals; Anticonvulsants; Epilepsy; Excitatory Postsynaptic Potentials; Prefrontal Cortex; Pyramidal | 2019 |
Valproate and female patients: Prescribing attitudes of Italian epileptologists.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Attitude of Health Personnel; Child; Epilepsy; Female; Hum | 2019 |
Vitamin D supplementation and bone markers in ambulatory children on long-term valproic acid therapy. A prospective interventional study.
Topics: Adolescent; Alkaline Phosphatase; Anticonvulsants; Biomarkers; Bone and Bones; Bone Remodeling; Chil | 2019 |
Why do some women with epilepsy use valproic acid despite current guidelines? A single-center cohort study.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Cohort Studies; Epilepsy; Female; H | 2019 |
Pharmacist impact on adherence of valproic acid therapy in pediatric patients with epilepsy using active education techniques.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; China; Epilepsy; Female; Humans; Infant; Male; | 2019 |
Self-reported attitudes about medication in Lebanese people with epilepsy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Attitude to Health; Carbamazepine; Cros | 2019 |
Valproate utilisation trends among girls and women from 2013 to 2018.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Utilization; Epilepsy; Female; Hum | 2019 |
Use of antiepileptic drugs in women of fertile age.
Topics: Adolescent; Adult; Anticonvulsants; Denmark; Epilepsy; Female; Gabapentin; Humans; Lamotrigine; Leve | 2019 |
ARX-associated infantile epileptic-dyskinetic encephalopathy with responsiveness to valproate for controlling seizures and reduced activity of muscle mitochondrial complex IV.
Topics: Adolescent; Adult; Asian People; China; Cytochrome-c Oxidase Deficiency; Dystonic Disorders; Epileps | 2019 |
Fragility fractures and reversible osteopaenia due to chronic hyponatraemia in an adolescent male.
Topics: Absorptiometry, Photon; Adolescent; Anticonvulsants; Bone Density; Bone Diseases, Metabolic; Epileps | 2019 |
A 16q22.2-q23.1 deletion identified in a male infant with West syndrome.
Topics: Anticonvulsants; Chromosomes, Human, Pair 16; Epilepsy; Humans; Infant; Intellectual Disability; Lam | 2019 |
Effects of Histone Deacetylase Inhibitors on the Development of Epilepsy and Psychiatric Comorbidity in WAG/Rij Rats.
Topics: Acetylation; Action Potentials; Animals; Avoidance Learning; Behavior, Animal; Butyric Acid; Comorbi | 2020 |
Risk factors for hyperammonemia in pediatric patients with epilepsy.
Topics: Acetazolamide; Adolescent; Age Factors; Anticonvulsants; Child; Child, Preschool; Dose-Response Rela | 2013 |
Associations between particular types of fetal malformation and antiepileptic drug exposure in utero.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Australia; Epilepsy; Female; Fetal Diseases; Fructose; | 2013 |
Unusual drug reaction between valproate sodium and meropenem.
Topics: Aged; Anti-Bacterial Agents; Anticonvulsants; Bacterial Infections; beta-Lactams; Drug Interactions; | 2013 |
[Patent rickets disclosed by loss of convulsion control in a boy with cerebral palsy].
Topics: Anticonvulsants; Calcium; Carbamazepine; Cerebral Palsy; Child, Preschool; Diazepam; Epilepsy; Human | 2013 |
Quantitative determination of valproic acid in postmortem blood samples--evidence of strong matrix dependency and instability.
Topics: Autopsy; Blood Preservation; Blood Specimen Collection; Death, Sudden; Dose-Response Relationship, D | 2013 |
[Carnitine deficiency with valproate sodium therapy--the difference by normal diet and enteral nutrition].
Topics: Adolescent; Adult; Carnitine; Child; Child, Preschool; Dietary Supplements; Enteral Nutrition; Epile | 2013 |
EEG improvements with antiepileptic drug treatment can show a high correlation with behavioral recovery in children with ADHD.
Topics: Adolescent; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Brain Waves; Child; Elec | 2013 |
Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism.
Topics: Adolescent; Adult; Anticonvulsants; Autistic Disorder; Child; Child Development Disorders, Pervasive | 2013 |
Risks of in utero exposure to valproate.
Topics: Anticonvulsants; Autistic Disorder; Child Development Disorders, Pervasive; Epilepsy; Female; Humans | 2013 |
Sodium valproate use is associated with reduced parietal lobe thickness and brain volume.
Topics: Adult; Brain; Cohort Studies; Epilepsy; Humans; Male; Middle Aged; Organ Size; Parietal Lobe; Valpro | 2013 |
Valproate in pregnancy linked to autism in children.
Topics: Anticonvulsants; Autistic Disorder; Denmark; Epilepsy; Female; Humans; Incidence; Infant, Newborn; P | 2013 |
Report: Fatal toxic epidermal necrolysis induced by sodium valproate.
Topics: Adult; Epilepsy; Fatal Outcome; Humans; Male; Stevens-Johnson Syndrome; Valproic Acid | 2013 |
Sodium valproate induced tremor in a patient with epilepsy and Down's syndrome.
Topics: Adolescent; Anticonvulsants; Down Syndrome; Epilepsy; GABA Agents; Humans; Male; Tremor; Valproic Ac | 2013 |
Valproate and lamotrigine in pediatric patients with refractory epilepsy: after the first year.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Female; H | 2013 |
Asymmetric drug-induced tremor: rare feature of a common event.
Topics: Anticonvulsants; Child; Epilepsy; Female; Humans; Tremor; Valproic Acid | 2013 |
Chronic valproic acid intoxication.
Topics: Anticonvulsants; Cerebral Palsy; Chemistry, Pharmaceutical; Child; Chronic Disease; Developmental Di | 2013 |
The effect of uridine diphosphate glucuronosyltransferase (UGT)1A6 genetic polymorphism on valproic acid pharmacokinetics in Indian patients with epilepsy: a pharmacogenetic approach.
Topics: Adolescent; Adult; Anticonvulsants; Child; Epilepsy; Female; Genetic Variation; Genotype; Glucuronos | 2013 |
The association between BsmI polymorphism and risk factors for atherosclerosis in patients with epilepsy taking valproate.
Topics: Adult; Anticonvulsants; Atherosclerosis; Cholesterol; Cross-Sectional Studies; Epilepsy; Female; Hum | 2013 |
Epilepsy and brain injury: a case report of a dramatic neuropsychiatric vicious circle.
Topics: Accidents, Traffic; Aggression; Amines; Anterior Temporal Lobectomy; Anticonvulsants; Brain Injuries | 2013 |
Atherogenic consequence of antiepileptic drugs: a study of intima-media thickness.
Topics: Adult; Age Factors; Anticonvulsants; Atherosclerosis; Carotid Arteries; Carotid Intima-Media Thickne | 2014 |
Valproic acid induced hyperammonaemic encephalopathy.
Topics: Adolescent; Adult; Anticonvulsants; Brain Diseases; Child; Child, Preschool; Cohort Studies; Epileps | 2013 |
Dose dependence of fetal malformations associated with valproate.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Austria; Dose-Response Relationship, Drug; Epilepsy; F | 2013 |
Initial anticonvulsant monotherapy in routine care of children and adolescents: levetiracetam fails more frequently than valproate and oxcarbazepine due to a lack of effectiveness.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Infan | 2014 |
The effects of topiramate and valproate therapy on insulin, c-peptide, leptin, neuropeptide Y, adiponectin, visfatin, and resistin levels in children with epilepsy.
Topics: Adiponectin; Anticonvulsants; Body Mass Index; Body Weight; C-Peptide; Child; Epilepsy; Female; Fruc | 2013 |
Effects of antiepileptic drugs on reproductive endocrine function, sexual function and sperm parameters in Chinese Han men with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Asian People; Epilepsy; Erectile Dysfunction; Follicle Stimulati | 2013 |
Ventricular ectopic beats in a child receiving carbamazepine.
Topics: Anticonvulsants; Carbamazepine; Child; Electrocardiography; Epilepsy; Humans; Male; Syncope; Valproi | 2013 |
[Characteristics of women with epilepsy who developed polycystic ovary syndrome owing to the therapy with valproate sodium].
Topics: Adolescent; Adult; Androstenedione; Epilepsy; Female; Humans; Polycystic Ovary Syndrome; Practice Gu | 2013 |
An unusual case of pleuropericardial neutrophilic effusion associated with valproate.
Topics: Adult; Cough; Dyspnea; Echocardiography; Epilepsy; Female; Humans; Pericardial Effusion; Pericardioc | 2015 |
Prenatal valproate exposure is associated with autism spectrum disorder and childhood autism.
Topics: Anticonvulsants; Autistic Disorder; Child Development Disorders, Pervasive; Epilepsy; Female; Humans | 2013 |
Effect of UGT2B7 genetic variants on serum valproic acid concentration.
Topics: Adolescent; Adult; Anticonvulsants; Asian People; Base Sequence; Child; Child, Preschool; Epilepsy; | 2013 |
Estimation and comparison of carbamazepine population pharmacokinetics using dried blood spot and plasma concentrations from people with epilepsy: the clinical implication.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Cross-Sectional Studies; Dried Blood Spot Testing; Drug | 2014 |
Prenatal exposure to sodium valproate is associated with increased risk of childhood autism and autistic spectrum disorder.
Topics: Anticonvulsants; Autistic Disorder; Child Development Disorders, Pervasive; Epilepsy; Female; Humans | 2014 |
Valproate use during pregnancy was linked to autism spectrum disorder and childhood autism in offspring.
Topics: Anticonvulsants; Autistic Disorder; Child Development Disorders, Pervasive; Epilepsy; Female; Humans | 2013 |
A case of selective immunoglobulin A deficiency with anti-neutrophil cytoplasmic antibody-associated glomerulonephritis.
Topics: Antibodies, Antineutrophil Cytoplasmic; Antibodies, Antinuclear; Anticonvulsants; Epilepsy; Female; | 2014 |
[Valproic acid during pregnancy lowers IQ in children].
Topics: Anticonvulsants; Epilepsy; Female; Humans; Intellectual Disability; Maternal-Fetal Exchange; Nervous | 2013 |
Malformation in index pregnancy in women with epilepsy is not followed by recurrence in subsequent pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; India; Pregna | 2013 |
Locally applied valproate enhances survival in rats after neocortical treatment with tetanus toxin and cobalt chloride.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cobalt; Disease Models, Animal; Electroencephalography; | 2013 |
Mystery case: a young boy with myoclonic jerks.
Topics: Adolescent; Electroencephalography; Epilepsy; Humans; Magnetic Resonance Imaging; Male; Myoclonus; P | 2013 |
Impact of planning of pregnancy in women with epilepsy on seizure control during pregnancy and on maternal and neonatal outcomes.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Humans; Pregnancy | 2014 |
Evaluation of anti-epileptic property of Marsilea quadrifolia Linn. in maximal electroshock and pentylenetetrazole-induced rat models of epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Electroshock; Epilepsy; Male; Marsileaceae; Pentylenet | 2013 |
Glia and epilepsy: experimental investigation of antiepileptic drugs in an astroglia/microglia co-culture model of inflammation.
Topics: Amines; Animals; Anticonvulsants; Astrocytes; Blotting, Western; Carbamazepine; Cells, Cultured; Coc | 2014 |
The impact of the use of antiepileptic drugs on the growth of children.
Topics: Adolescent; Anticonvulsants; Body Height; Bone Diseases, Developmental; Calcium; Carbamazepine; Cell | 2013 |
Influence of uridine diphosphate glucuronosyltransferase 2B7 -161C>T polymorphism on the concentration of valproic acid in pediatric epilepsy patients.
Topics: Age Factors; Anticonvulsants; Body Weight; Child; Child, Preschool; Cytochrome P-450 CYP2C9; Drug Th | 2014 |
Drug interaction between phenytoin and valproic acid in a child with refractory epilepsy: a case report.
Topics: Anticonvulsants; Child; Drug Interactions; Epilepsy; Female; Humans; Phenytoin; Valproic Acid | 2014 |
In utero exposure to levetiracetam vs valproate: development and language at 3 years of age.
Topics: Adult; Anticonvulsants; Child Development; Child, Preschool; Epilepsy; Female; Humans; Language Deve | 2014 |
Reproductive endocrine health in pubertal females with epilepsy on antiepileptic drugs: time to screen?
Topics: Adiposity; Adolescent; Anticonvulsants; Cohort Studies; Cross-Sectional Studies; Drug Evaluation, Pr | 2014 |
The effects of valproic acid and carbamazepine on strength-duration properties of peripheral nerve.
Topics: Adolescent; Adult; Anticonvulsants; Biophysics; Carbamazepine; Child; Electric Stimulation; Electroe | 2014 |
[Season fluctuations of carbamazepine and valproate concentration in patients with epilepsy].
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Male; Middle Aged; Seasons; Valproi | 2013 |
Malformation risks of antiepileptic drug monotherapies in pregnancy: updated results from the UK and Ireland Epilepsy and Pregnancy Registers.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug | 2014 |
Fetal growth restriction and birth defects with newer and older antiepileptic drugs during pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Birth Weight; Cohort Studies; Epilepsy; Female; | 2014 |
[Valproate should be avoided in pregnancy].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Prenatal Exposure | 2014 |
[Valproic acid concentration in the blood serum of pregnant women and umbilical cord blood in relation to the condition of the newborn--case studies].
Topics: Adult; Anticonvulsants; Epilepsy; Female; Fetal Blood; Humans; Infant, Newborn; Pregnancy; Pregnancy | 2013 |
Vitamin D levels in children and adolescents with antiepileptic drug treatment.
Topics: Adolescent; Anticonvulsants; Bone Density; Bone Diseases, Metabolic; Carbamazepine; Child; Child, Pr | 2014 |
Lacosamide serum concentrations in adult patients with epilepsy: the influence of gender, age, dose, and concomitant antiepileptic drugs.
Topics: Acetamides; Adult; Aged; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Inte | 2014 |
[Epilepsy and transverse sternum fractures: sternum fractures in drug-induced osteopenia].
Topics: Adult; Anticonvulsants; Bone Diseases, Metabolic; Bone Plates; Epilepsy; Female; Fracture Fixation, | 2014 |
Hemiconvulsion-hemiplegia-epilepsy syndrome: clinical course and neuroradiological features in a 20-month-old girl.
Topics: Anticonvulsants; Atrophy; Brain; Carbamazepine; Epilepsy; Female; Hemiplegia; Humans; Infant; Syndro | 2014 |
Busulfan triggers epileptic seizures under levetiracetam and valproic acid therapy.
Topics: Adolescent; Anticonvulsants; Busulfan; Drug Therapy, Combination; Epilepsy; Female; Hematopoietic St | 2014 |
Characterization of a lamotrigine-resistant kindled model of epilepsy in mice: evaluation of drug resistance mechanisms.
Topics: Animals; Anticonvulsants; Calcium Channels; Carbamazepine; Disease Models, Animal; Drug Resistance; | 2014 |
Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism.
Topics: Anticonvulsants; Autistic Disorder; Child Development Disorders, Pervasive; Epilepsy; Female; Humans | 2014 |
Sodium valproate-related hyperammonaemic encephalopathy.
Topics: Anticonvulsants; Epilepsy; Humans; Hyperammonemia; Male; Middle Aged; Neurotoxicity Syndromes; Valpr | 2014 |
Effect of the entorhinal cortex on ictal discharges in low-Mg²⁺-induced epileptic hippocampal slice models.
Topics: Animals; Anticonvulsants; CA1 Region, Hippocampal; Data Interpretation, Statistical; Electroencephal | 2014 |
Evaluation of thyroid hormones in children receiving carbamazepine or valproate: a prospective study.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Humans; Male; Prospective Studi | 2015 |
First manic episode due to discontinuation of valproic acid in a patient with epilepsy.
Topics: Adult; Anticonvulsants; Bipolar Disorder; Drug Administration Schedule; Epilepsy; Female; Humans; Va | 2014 |
Population pharmacokinetics of valproic acid in adult Chinese epileptic patients and its application in an individualized dosage regimen.
Topics: Adolescent; Adult; Aged; Algorithms; Anticonvulsants; Asian People; Chemistry, Pharmaceutical; Delay | 2015 |
Hyperammonemia associated with valproic acid concentrations.
Topics: Adolescent; Adult; Ammonia; Bipolar Disorder; Carnitine; Child; Dietary Supplements; Dose-Response R | 2014 |
Chronic valproate or levetiracetam treatment does not influence cytokine levels in humans.
Topics: Anticonvulsants; Blood Chemical Analysis; Cytokines; Enzyme-Linked Immunosorbent Assay; Epilepsy; Fe | 2014 |
4217C>A polymorphism in carbamoyl-phosphate synthase 1 gene may not associate with hyperammonemia development during valproic acid-based therapy.
Topics: Alleles; Amino-Acid N-Acetyltransferase; Ammonia; Anticonvulsants; Asian People; Biomarkers, Pharmac | 2014 |
Is sodium valproate, an HDAC inhibitor, associated with reduced risk of stroke and myocardial infarction? A nested case-control study.
Topics: Aged; Aged, 80 and over; Bias; Brain Ischemia; Case-Control Studies; Databases, Factual; Electronic | 2014 |
Vascular function and risk factors in children with epilepsy: associations with sodium valproate and carbamazepine.
Topics: Adolescent; Anticonvulsants; Aorta; Blood Glucose; Brachial Artery; Carbamazepine; Carotid Arteries; | 2014 |
Reboxetine and its influence on the action of classical antiepileptic drugs in the mouse maximal electroshock model.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Drug Interactions; Electrosh | 2014 |
Valproate and folic acid in pregnancy: associations with autism.
Topics: Autistic Disorder; Epilepsy; Female; Folic Acid; Humans; Pregnancy; Prenatal Exposure Delayed Effect | 2014 |
Effects of conventional anticonvulsant drugs on generalized tonic-clonic seizures in Noda epileptic rats.
Topics: Animals; Anticonvulsants; Brain Waves; Disease Models, Animal; Dose-Response Relationship, Drug; Ele | 2014 |
Does nephrotoxicity exist in pediatric epileptic patients on valproate or carbamazepine therapy?
Topics: Adolescent; Anticonvulsants; Carbamazepine; Case-Control Studies; Child; Creatinine; Cystatin C; Epi | 2015 |
[Effects of carbamazepine on plasma concentrations of valproic acid and its toxic metabolite in epileptic patients].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epi | 2014 |
The teratogenicity of the newer antiepileptic drugs - an update.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Epilepsy; Female; Fetus; Fructose; Humans; Lamo | 2014 |
Comparison of the metabolic syndrome risk in valproate-treated patients with epilepsy and the general population in Estonia.
Topics: Adult; Anticonvulsants; Case-Control Studies; Epilepsy; Estonia; Female; Humans; Male; Metabolic Syn | 2014 |
Weight and fat distribution in patients taking valproate: a valproate-discordant gender-matched twin and sibling pair study.
Topics: Abdominal Fat; Absorptiometry, Photon; Adult; Anticonvulsants; Blood Pressure; Body Composition; Bod | 2014 |
Endocrine effects of valproic acid therapy in girls with epilepsy: a prospective study.
Topics: Adolescent; Anthropometry; Anticonvulsants; Child; Endocrine System; Epilepsy; Female; Humans; Longi | 2014 |
An effective assessment of valproate sodium-induced hepatotoxicity with UPLC-MS and (1)HNMR-based metabonomics approach.
Topics: Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid | 2014 |
Asymmetric dimethylarginine and vascular risk in patients treated with antiepileptic drugs.
Topics: Anticonvulsants; Aorta; Brachial Artery; Carbamazepine; Carotid Arteries; Epilepsy; Female; Humans; | 2014 |
Risk factors of hyperammonemia in patients with epilepsy under valproic acid therapy.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Ammonia; Anticonvulsants; Antipsychotic Age | 2014 |
Effect of comedication on lamotrigine clearance in Korean epilepsy patients.
Topics: Adult; Anticonvulsants; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Female; Half- | 2015 |
Clinical validation and implications of dried blood spot sampling of carbamazepine, valproic acid and phenytoin in patients with epilepsy.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Dried Blood Spot Testing; Drug Monitoring; Drug Therapy | 2014 |
Degeneration and regeneration of GABAergic interneurons in the dentate gyrus of adult mice in experimental models of epilepsy.
Topics: Animals; Chronic Disease; Dentate Gyrus; Epilepsy; GABAergic Neurons; Glutamate Decarboxylase; Green | 2015 |
Validation of a multigenic model to predict seizure control in newly treated epilepsy.
Topics: Adult; Algorithms; Anticonvulsants; Artificial Intelligence; Australia; Biomarkers, Pharmacological; | 2014 |
[Convulsions due to an interaction between anti-epileptic drugs and rifampicin].
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Cytochrome P-450 Enzyme System; Drug Interactions; Epile | 2014 |
Impact of the superoxide dismutase 2 Val16Ala polymorphism on the relationship between valproic acid exposure and elevation of γ-glutamyltransferase in patients with epilepsy: a population pharmacokinetic-pharmacodynamic analysis.
Topics: Adolescent; Adult; Algorithms; Amino Acid Substitution; Anticonvulsants; Child; Child, Preschool; Ep | 2014 |
Nonlinear mixed effects modelling approach in investigating phenobarbital pharmacokinetic interactions in epileptic patients.
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epilepsy; Femal | 2015 |
A population pharmacokinetic model of valproic acid in pediatric patients with epilepsy: a non-linear pharmacokinetic model based on protein-binding saturation.
Topics: Adolescent; Age Factors; Anticonvulsants; Body Weight; Carbamazepine; Child; Child, Preschool; Drug | 2015 |
[Valproate can induce reversible encephalopathy].
Topics: Aged; Anticonvulsants; Brain Diseases; Epilepsy; Female; Humans; Magnetic Resonance Imaging; Neuroto | 2014 |
Response to "Asymmetric dimethylarginine and vascular risk in patients treated with antiepileptic drugs".
Topics: Anticonvulsants; Aorta; Brachial Artery; Carbamazepine; Carotid Arteries; Epilepsy; Female; Humans; | 2014 |
Correlation of saliva and serum free valproic acid concentrations in persons with epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Chromatography, High Pressure Liquid; Drug Therapy, | 2015 |
Antiepileptic treatment in a child with Landau Kleffner syndrome: a case report.
Topics: Anticonvulsants; Child, Preschool; Diagnosis, Differential; Epilepsy; Humans; Landau-Kleffner Syndro | 2014 |
Extending the use of stiripentol to other epileptic syndromes: a case of PCDH19-related epilepsy.
Topics: Age of Onset; Anticonvulsants; Autistic Disorder; Benzodiazepines; Cadherins; Child; Clobazam; Cogni | 2015 |
[Clinical misdiagnosis analysis of valproate encephalopathy].
Topics: Anticonvulsants; Brain Diseases; Brain Edema; Brain Neoplasms; Diagnostic Errors; Epilepsy; Humans; | 2014 |
Cosmetic side effects of antiepileptic drugs in adults with epilepsy.
Topics: Acne Vulgaris; Adult; Alopecia; Anticonvulsants; Epilepsy; Female; gamma-Aminobutyric Acid; Gingival | 2015 |
Effects of phenytoin and valproic acid on cognitive functions of Thai epileptic patients: a pilot study.
Topics: Adolescent; Adult; Anticonvulsants; Asian People; Carbamazepine; Case-Control Studies; Cognition; Ep | 2014 |
IQ at 6 years after in utero exposure to antiepileptic drugs: a controlled cohort study.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Child Development; Epilepsy; Female; Humans; Intellige | 2015 |
Fine-tuning risk assessment with antiepileptic drug use in pregnancy.
Topics: Anticonvulsants; Carbamazepine; Child Development; Epilepsy; Female; Humans; Intelligence; Lamotrigi | 2015 |
Carnitine deficiency: Risk factors and incidence in children with epilepsy.
Topics: Adolescent; Anticonvulsants; Cardiomyopathies; Carnitine; Case-Control Studies; Child; Child, Presch | 2015 |
Valproate fetopathy.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Diagnostic Imaging; Epilepsy; Female; Fetal Di | 2015 |
Pharmacological interaction between valproic acid and carbapenem: what about levels in pediatrics?
Topics: Adolescent; Anticonvulsants; Carbapenems; Child; Child, Preschool; Drug Interactions; Drug Therapy, | 2015 |
Comparative behavioral and neurochemical analysis of phenytoin and valproate treatment on epilepsy induced learning and memory deficit: Search for add on therapy.
Topics: Acetylcholinesterase; Animals; Anticonvulsants; Cerebral Cortex; Drug Therapy, Combination; Epilepsy | 2015 |
Standard dose valproic acid does not cause additional cognitive impact in a rodent model of intractable epilepsy.
Topics: Animals; Animals, Newborn; Anticonvulsants; Cognition; Cognition Disorders; Disease Models, Animal; | 2015 |
A granulocytosis associated with rufinamide: A case report.
Topics: Agranulocytosis; Anticonvulsants; Child; Clonazepam; Epilepsy; Humans; Male; Triazoles; Valproic Aci | 2015 |
Valproate and pregnancy: think again.
Topics: Anticonvulsants; Carbamazepine; Child Development; Epilepsy; Female; Humans; Intelligence; Lamotrigi | 2015 |
The effects of antiepileptic drug valproic acid on apoptosis of hippocampal neurons in epileptic rats.
Topics: Animals; Anticonvulsants; Apoptosis; bcl-2-Associated X Protein; Electroencephalography; Epilepsy; H | 2015 |
Seminal fluid analysis and testicular volume in adults with epilepsy receiving valproate.
Topics: Adult; Anticonvulsants; Epilepsy; Humans; Male; Organ Size; Semen; Sperm Count; Sperm Motility; Sper | 2015 |
Association of LEPR and ANKK1 Gene Polymorphisms with Weight Gain in Epilepsy Patients Receiving Valproic Acid.
Topics: Adolescent; Adult; AMP-Activated Protein Kinases; Anticonvulsants; Body Weight; Chromatography, High | 2015 |
Effects of chronic administration of valproic acid to epileptic patients on coagulation tests and primary hemostasis.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adolescent; Adult; Anticonvulsants; Blood Coagulation | 2015 |
Endocrine Effects of Valproate versus Carbamazepine in Males with Epilepsy: A Prospective Study.
Topics: Adolescent; Anticonvulsants; Body Height; Body Weight; Carbamazepine; Child; Epilepsy; Humans; Male; | 2015 |
Valproate-induced enuresis: a prospective study.
Topics: Age Factors; Anticonvulsants; Child; Child, Preschool; Enuresis; Epilepsy; Female; Humans; Male; Pro | 2015 |
Antiepileptic drugs in Rett Syndrome.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Lamotrigine; Male | 2015 |
[Use of valproic acid in long stay units of psychiatry].
Topics: Adult; Aged; Antimanic Agents; Bipolar Disorder; Cross-Sectional Studies; Epilepsy; Female; Humans; | 2015 |
Reduction of epileptiform activity by valproic acid in a mouse model of Alzheimer's disease is not long-lasting after treatment discontinuation.
Topics: Acetylation; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Anti | 2015 |
Analysis of variability of concentrations of valproic acid (VPA) and its selected metabolites in the blood serum of patients treated with VPA and patients hospitalized because of VPA poisoning.
Topics: Anticonvulsants; Bipolar Disorder; Drug Overdose; Epilepsy; Female; Humans; Male; Peripheral Nervous | 2014 |
Effects of antiepileptic drug monotherapy on one-carbon metabolism and DNA methylation in patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Case-Control Studies; Cross-Sectional Studies; DNA Methylation; | 2015 |
Effects of UGT1A4 genetic polymorphisms on serum lamotrigine concentrations in Chinese children with epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; China; Drug Interactions; Drug Therapy, Combin | 2015 |
Clinical significance of CYP2C9-status guided valproic acid therapy in children.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Cytochrome P-450 CYP2C9; Drug-Related Side Eff | 2015 |
An Evaluation of Peripapillary Retinal Nerve Fiber Layer Thickness in Children With Epilepsy Receiving Treatment of Valproic Acid.
Topics: Adolescent; Anticonvulsants; Child; Epilepsy; Eye; Female; Humans; Male; Organ Size; Tomography, Opt | 2015 |
Commentary: Valproate in the treatment of epilepsy in women and girls: The need for recommendations.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Valproic Acid | 2015 |
Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Docosahexaenoic Acids; Dose-Response Relationship, | 2015 |
A prospective study of adverse drug reactions to antiepileptic drugs in children.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cognition Disorders; Drug Thera | 2015 |
Epilepsy in children with tuberous sclerosis complex: Chance of remission and response to antiepileptic drugs.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diet, Ketogenic; Epilepsies, Partial; Epilepsy | 2015 |
Commentary: Revised recommendation from CMDh on use of valproate in women is ethically incomplete and neglects the interests of women.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Valproic Acid | 2015 |
Muscle Weakness and Pain With Profound Hypophosphatemia: Mystery Revealed.
Topics: Adolescent; Epilepsy; Fanconi Syndrome; Humans; Hypophosphatemia; Male; Muscle Weakness; Valproic Ac | 2015 |
Dose-dependent teratogenicity of valproate in mono- and polytherapy: an observational study.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Dose-Response Relationship, Drug; D | 2015 |
The influence of UGT2B7 genotype on valproic acid pharmacokinetics in Chinese epilepsy patients.
Topics: Adult; Alleles; Anticonvulsants; Asian People; Epilepsy; Female; Genotype; Glucuronosyltransferase; | 2015 |
Effect of Carbamazepine and Valproate Monotherapy on Cardiovascular Risks in Epileptic Children.
Topics: Anticonvulsants; Apolipoproteins A; Apolipoproteins B; Blood Chemical Analysis; Carbamazepine; Cardi | 2015 |
Involvement of p38 MAPK in the Drug Resistance of Refractory Epilepsy Through the Regulation Multidrug Resistance-Associated Protein 1.
Topics: Animals; Chromatography, High Pressure Liquid; Drug Resistance; Epilepsy; Lamotrigine; Male; Microdi | 2015 |
Changes in the anti-oxidant system in adult epilepsy patients receiving anti-epileptic drugs.
Topics: Acetylcholinesterase; Adult; Anticonvulsants; Antioxidants; Aryldialkylphosphatase; Carbamazepine; C | 2015 |
Valproate still has a place in women with epilepsy.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Valproic Acid | 2015 |
Recurrent seizures during acute acquired toxoplasmosis in an immunocompetent traveller returning from Africa.
Topics: Adolescent; Antibodies, Protozoan; Anticonvulsants; Antiprotozoal Agents; Epilepsy; Ethiopia; Humans | 2016 |
Impact of epilepsy and antiepileptic medications on the metabolic profile in adults with autism spectrum disorder and intellectual disabilities.
Topics: Adult; Anticonvulsants; Autism Spectrum Disorder; Blood Glucose; Body Mass Index; Carbamazepine; Cho | 2015 |
Dynamics of hydroxyoctadecadienoic acid in epilepsy patients treated with valproic acid.
Topics: Adolescent; Anticonvulsants; Biomarkers; Child; Child, Preschool; Epilepsy; Fatty Acids, Unsaturated | 2016 |
Reduction of epileptiform activity through local valproate-implants in a rat neocortical epilepsy model.
Topics: Animals; Anticonvulsants; Cobalt; Disease Models, Animal; Drug Implants; Electrocorticography; Elect | 2015 |
Epileptogenesis and epileptic maturation in phosphorylation site-specific SNAP-25 mutant mice.
Topics: Animals; Anticonvulsants; Anxiety; Blotting, Western; Brain; Disease Progression; Electrocorticograp | 2015 |
Cytochrome P450 2C19 polymorphisms and valproic acid-induced weight gain.
Topics: Adolescent; Anticonvulsants; Body Mass Index; Carbamazepine; Child; Cytochrome P-450 CYP2C19; Epilep | 2016 |
Valproate modulates glucose metabolism in patients with epilepsy after first exposure.
Topics: Adolescent; Adult; Anticonvulsants; Blood Glucose; Cross-Over Studies; Epilepsy; Female; Glucose; Hu | 2015 |
The investigation of EEG specificity in epileptic children during Depakine therapy.
Topics: Anticonvulsants; Brain Waves; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Outcome Asses | 2016 |
[The prevalence of obesity and metabolic syndrome in paediatric patients with epilepsy treated in monotherapy with valproic acid].
Topics: Adolescent; Anticonvulsants; Child; Cross-Sectional Studies; Epilepsy; Female; Humans; Male; Metabol | 2015 |
A LC-MS/MS method for therapeutic drug monitoring of carbamazepine, lamotrigine and valproic acid in DBS.
Topics: Anticonvulsants; Calibration; Carbamazepine; Child; Chromatography, Liquid; Dried Blood Spot Testing | 2015 |
[Valproic acid responsible for low IQ].
Topics: Anticonvulsants; Carbamazepine; Child Development; Epilepsy; Female; Humans; Intelligence; Male; Pre | 2015 |
Changing incidence of hyperammonemia in Japan from 2006 to 2013: expansion of new antiepileptic drugs reduces the risk of hyperammonemia.
Topics: Adolescent; Adult; Anticonvulsants; Child; Drug Interactions; Drug Therapy, Combination; Epilepsy; F | 2015 |
Trends in Antiepileptic Drug Prescriptions for Childhood Epilepsy at a Tertiary Children's Hospital in Korea, 2001-2012.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Prescriptions; Epilepsy; F | 2015 |
Prognostic relevance of epilepsy at presentation in glioblastoma patients.
Topics: Adult; Anticonvulsants; Brain Neoplasms; Epilepsy; Female; Glioblastoma; Humans; Immunohistochemistr | 2016 |
Effects of CYP3A4/5 and ABCB1 genetic polymorphisms on carbamazepine metabolism and transport in Chinese patients with epilepsy treated with carbamazepine in monotherapy and bitherapy.
Topics: Adolescent; Adult; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; Carbamazepine; Ch | 2015 |
Evaluate the Effect of Valproate Monotherapy on the Serum Homocysteine, Folate and Vitamin B12 Levels in Epileptic Children.
Topics: Adolescent; Age Factors; Anticonvulsants; Case-Control Studies; Child; Child, Preschool; Drug Monito | 2015 |
[Position Statement of Hungarian Epilepsy League: The use of valproate preparations for epilepsy in pregnancy and in women of childbearing age].
Topics: Adolescent; Adult; Anticonvulsants; Cognition; Contraception; Dose-Response Relationship, Drug; Drug | 2015 |
Fine-tuning risk assessment with antiepileptic drug use in pregnancy.
Topics: Anticonvulsants; Carbamazepine; Child Development; Epilepsy; Female; Humans; Intelligence; Male; Pre | 2015 |
Determination of the Optimal Concentration of Valproic Acid in Patients with Epilepsy: A Population Pharmacokinetic-Pharmacodynamic Analysis.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Child, Preschool; Drug Interactions; Epileps | 2015 |
Serum levels of valproic acid during delivery in mothers and in umbilical cord - correlation with birth length and weight.
Topics: Anticonvulsants; Biomarkers; Body Height; Body Weight; Delivery, Obstetric; Dose-Response Relationsh | 2015 |
[Valproate can induce reversible encephalopathy].
Topics: Aged; Anticonvulsants; Brain Diseases; Epilepsy; Female; Humans; Magnetic Resonance Imaging; Neuroto | 2015 |
Influence of glutamine synthetase gene polymorphisms on the development of hyperammonemia during valproic acid-based therapy.
Topics: Adolescent; Ammonia; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Genotype; Glutamate | 2015 |
[Meropenem and valproic acid: A clinically relevant drug-drug interaction].
Topics: Adult; Anti-Bacterial Agents; Anticonvulsants; Drug Interactions; Epilepsy; Female; Fructose; Humans | 2016 |
Specific adverse effects of antiepileptic drugs--A true-to-life monotherapy study.
Topics: Adult; Aged; Anticonvulsants; Anxiety; Carbamazepine; Depression; Drug-Related Side Effects and Adve | 2016 |
Effects of UGT2B7 Genetic Polymorphisms on Serum Concentrations of Valproic Acid in Chinese Children With Epilepsy Comedicated With Lamotrigine.
Topics: Adolescent; Age Factors; Anticonvulsants; Asian People; Child; Child, Preschool; Chromatography, Hig | 2016 |
The COL1A1 SP1 polymorphism is associated with lower bone mineral density in patients treated with valproic acid.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Bone Density; Collagen Type I; Collagen Type I, alp | 2016 |
Use of antiepileptic drugs during pregnancy and lactation: Type of information provided by searching Google.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans | 2016 |
Does Valproic Acid or Levetiracetam Improve Survival in Glioblastoma? A Pooled Analysis of Prospective Clinical Trials in Newly Diagnosed Glioblastoma.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemor | 2016 |
Auditory hallucinations preceding migraine, differentiation with epileptic origin: A case report.
Topics: Adult; Anticonvulsants; Brain; Diagnosis, Differential; Epilepsy; Follow-Up Studies; Hallucinations; | 2016 |
Outcome of renal proximal tubular dysfunction with Fanconi syndrome caused by sodium valproate.
Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Fanconi Syndrome; Female; Follow-Up Studies; Hum | 2016 |
Prescribing trends for sodium valproate in Ireland.
Topics: Adolescent; Adult; Anticonvulsants; Drug Prescriptions; Epilepsy; Female; Folic Acid; Humans; Irelan | 2016 |
Factors influencing topiramate clearance in adult patients with epilepsy: A population pharmacokinetic analysis.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fructose; Humans; Male; M | 2016 |
Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistance; Epilepsy; GABA Antagoni | 2016 |
[A girl with foetal valproate syndrome and autism spectrum disorder].
Topics: Anticonvulsants; Autistic Disorder; Child; Child Development Disorders, Pervasive; Epilepsy; Female; | 2016 |
Various simultaneous nail changes due to valproic acid use.
Topics: Anticonvulsants; Epilepsy; Humans; Male; Middle Aged; Nails; Pigmentation; Valproic Acid | 2017 |
Concentrations of carbamazepine and carbamazepine-10,11-epoxide in maternal and umbilical cord blood at birth: Influence of co-administration of valproic acid or enzyme-inducing antiepileptic drugs.
Topics: Adolescent; Adult; Anticonvulsants; Blood Chemical Analysis; Carbamazepine; Dose-Response Relationsh | 2016 |
Weight gain in children on oxcarbazepine monotherapy.
Topics: Adolescent; Anticonvulsants; Body Mass Index; Carbamazepine; Child; Child, Preschool; Epilepsy; Fema | 2016 |
France steps up warning measures for valproate drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Drug and Narcotic Control; Drug Information Services; | 2016 |
The effects of co-medications on lamotrigine clearance in Japanese children with epilepsy.
Topics: Adolescent; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Child, Preschool; Clobazam; Clon | 2016 |
Considering Valproate as a Risk Factor for Rapid Exacerbation of Complex Movement Disorder in Progressed Stages of Late-Infantile CLN2 Disease.
Topics: Anticonvulsants; Child; Child, Preschool; Consciousness Disorders; Creatine Kinase; Deprescriptions; | 2016 |
Metabolic syndrome and anticonvulsants: A comparative study of valproic acid and carbamazepine.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Male; Metabolic Syndrome; Mid | 2016 |
Serum levels of zinc and copper in epileptic children during long-term therapy with anticonvulsants.
Topics: Anticonvulsants; Child; Copper; Epilepsy; Humans; Valproic Acid; Zinc | 2016 |
Duration of valproic acid monotherapy correlates with subclinical thyroid dysfunction in children with epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Cross-Sectional Studies; Epilepsy; Female; Hum | 2016 |
An investigation of the influence of patient-related factors and comedications on lamotrigine clearance in patients with epilepsy.
Topics: Adult; Anticonvulsants; Body Weight; Dose-Response Relationship, Drug; Drug Interactions; Drug Thera | 2016 |
Medication prescribing and patient-reported outcome measures in people with epilepsy in Bhutan.
Topics: Adult; Aged; Anticonvulsants; Bhutan; Carbamazepine; Drug Prescriptions; Electroencephalography; Epi | 2016 |
Should women of childbearing potential be prescribed valproate? a call to action.
Topics: Abnormalities, Drug-Induced; Bipolar Disorder; Contraception Behavior; Epilepsy; Female; Humans; Inf | 2016 |
Potential effects of valproate and oxcarbazepine on growth velocity and bone metabolism in epileptic children- a medical center experience.
Topics: Adolescent; Anticonvulsants; Bone Remodeling; Carbamazepine; Case-Control Studies; Child; Child, Pre | 2016 |
Bone health and vitamin D status in young epilepsy patients on valproate monotherapy.
Topics: Adult; Anticonvulsants; Bone Density; Cohort Studies; Epilepsy; Female; Humans; Male; Valproic Acid; | 2016 |
Adjuvant indoleamine 2,3-dioxygenase enzyme inhibition for comprehensive management of epilepsy and comorbid depression.
Topics: Animals; Comorbidity; Corticosterone; Depression; Drug Interactions; Enzyme Inhibitors; Epilepsy; Hi | 2016 |
Differential impact of contraceptive methods on seizures varies by antiepileptic drug category: Findings of the Epilepsy Birth Control Registry.
Topics: Adult; Anticonvulsants; Contraception; Contraceptive Agents; Contraceptives, Oral, Hormonal; Epileps | 2016 |
Comparison of body composition in persons with epilepsy on conventional & new antiepileptic drugs.
Topics: Adult; Anticonvulsants; Benzodiazepines; Body Composition; Body Water; Body Weight; Carbamazepine; C | 2016 |
Antiepileptic drug combinations not involving valproate and the risk of fetal malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cohort Studies; Dose-Response Relationship, Drug; Drug | 2016 |
Withdrawal of valproic acid treatment during pregnancy and seizure outcome: Observations from EURAP.
Topics: Adolescent; Adult; Anticonvulsants; Bayes Theorem; Cohort Studies; Epilepsy; Female; Humans; Interna | 2016 |
Patterns of antiepileptic drugs use in epileptic pediatric patients in Jordan.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cross-Sectional Studies; Drug T | 2016 |
Influence of acylpeptide hydrolase polymorphisms on valproic acid level in Chinese epilepsy patients.
Topics: Adult; Anticonvulsants; Asian People; Epilepsy; Female; Genotype; Glucuronosyltransferase; Humans; M | 2016 |
Steady-state pharmacokinetic simulation of intermittent vs. continuous infusion valproic acid therapy in non-critically ill and critically ill patients.
Topics: Adult; Anticonvulsants; Cohort Studies; Critical Illness; Dose-Response Relationship, Drug; Drug Adm | 2016 |
Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment.
Topics: Animals; Anticonvulsants; Brain; Callithrix; Carbamazepine; Chronic Disease; Disease Models, Animal; | 2016 |
Fetal Valproate Syndrome.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child, Preschool; Craniofacial Abnormalities; Cryptorc | 2017 |
Evidence in support of using a neurochemistry approach to identify therapy for both epilepsy and associated depression.
Topics: Animals; Anticonvulsants; Brain; Depression; Depressive Disorder; Disease Models, Animal; Dopamine; | 2016 |
Clinical features of patients with game-induced seizures in the Chinese population.
Topics: Adolescent; Adult; Age Distribution; Anticonvulsants; Asian People; Child; Electroencephalography; E | 2016 |
In response: Commentary on clinical significance of CYP2C9-status-guided valproic acid therapy in children.
Topics: Anticonvulsants; Child; Cytochrome P-450 CYP2C9; Epilepsy; Female; Humans; Hyperammonemia; Male; Val | 2016 |
Resting-state fMRI revealed different brain activities responding to valproic acid and levetiracetam in benign epilepsy with central-temporal spikes.
Topics: Anticonvulsants; Brain; Child; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; F | 2017 |
The consequences of valproate exposure in utero.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Prenatal Exposure Delayed Effects; Valproic Acid | 2016 |
Cognition in school-age children exposed to levetiracetam, topiramate, or sodium valproate.
Topics: Adult; Anticonvulsants; Child; Cognition Disorders; Cross-Sectional Studies; Epilepsy; Female; Follo | 2016 |
Comparative persistence of antiepileptic drugs in patients with epilepsy: A STROBE-compliant retrospective cohort study.
Topics: Adolescent; Adult; Aged; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Epilep | 2016 |
Does valproate therapy in epileptic patients contribute to changing atherosclerosis risk factors? The role of lipids and free fatty acids.
Topics: Adult; Atherosclerosis; Cohort Studies; Cross-Sectional Studies; Epilepsy; Fatty Acids, Nonesterifie | 2016 |
Efficacy and tolerability of anti-epileptic drugs-an internet study.
Topics: Adult; Anticonvulsants; Carbamazepine; Depression; Epilepsy; Female; Humans; Internet; Lamotrigine; | 2017 |
Serious and reversible levetiracetam-induced psychiatric symptoms after resection of frontal low-grade glioma: two case histories.
Topics: Anticonvulsants; Brain Neoplasms; Craniotomy; Epilepsy; Frontal Lobe; Humans; Levetiracetam; Magneti | 2017 |
Women are unaware of pregnancy risks linked with sodium valproate.
Topics: Anticonvulsants; Developmental Disabilities; Epilepsy; Female; Health Knowledge, Attitudes, Practice | 2016 |
[Caution and warning: About valproate and pregnancy].
Topics: Adult; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Epilepsy; Female; Humans; Pregnancy; Pre | 2016 |
Effects of UGT1A6 and GABRA1 on Standardized Valproic Acid Plasma Concentrations and Treatment Effect in Children With Epilepsy in China.
Topics: Adolescent; Age Factors; Anticonvulsants; Asian People; Child; Child, Preschool; China; Dose-Respons | 2016 |
Status epilepticus in pregnant women with epilepsy after valproate adjustment: A case series.
Topics: Adult; Anticonvulsants; Electroencephalography; Epilepsy; Female; Humans; Pregnancy; Retrospective S | 2016 |
Polymorphisms of ABAT, SCN2A and ALDH5A1 may affect valproic acid responses in the treatment of epilepsy in Chinese.
Topics: 4-Aminobutyrate Transaminase; Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female | 2016 |
Adjuvant neuronal nitric oxide synthase inhibition for combined treatment of epilepsy and comorbid depression.
Topics: Animals; Anticonvulsants; Chemotherapy, Adjuvant; Depression; Dose-Response Relationship, Drug; Enzy | 2017 |
Antiepileptic drugs in migraine and epilepsy: Who is at increased risk of adverse events?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Child; Epilepsy; Female; Humans; Lamotr | 2018 |
Effectiveness and tolerability of antiepileptic drugs in 104 girls with Rett syndrome.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Therap | 2017 |
Simultaneous Determination of Valproic Acid and Its Major Metabolites by UHPLC-MS/MS in Chinese Patients: Application to Therapeutic Drug Monitoring.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; China; Chromatography, High Pressure Li | 2017 |
Cognitive functions in children exposed to antiepileptic drugs in utero - Study in Georgia.
Topics: Adult; Anticonvulsants; Child; Child Development; Child, Preschool; Cognition; Cohort Studies; Epile | 2017 |
Combining adverse pregnancy and perinatal outcomes for women exposed to antiepileptic drugs during pregnancy, using a latent trait model.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Epilepsy; Female; Florida; Humans; Infant, Low | 2017 |
Prenatal exposure to antiepileptic drugs and use of primary healthcare during childhood: a population-based cohort study in Denmark.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Denmark; Epilepsy; Femal | 2017 |
Sulforaphane protects against sodium valproate-induced acute liver injury.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Anticonvulsants; A | 2017 |
[Therapeutic drug monitoring of three antiepileptic drugs - Back on twenty years of experience].
Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Monitoring; Epilepsy; Humans; | 2016 |
Associations between genetic variation in one-carbon metabolism and leukocyte DNA methylation in valproate-treated patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Case-Control Studies; DNA Methylation; Epilepsy; Female; Humans; | 2018 |
Valproate acid (VPA)-induced dysmetabolic function in clinical and animal studies.
Topics: Adipose Tissue; Adult; Anticonvulsants; Epilepsy; Fatty Acid-Binding Proteins; Female; Gene Expressi | 2017 |
Trimetazidine potentiates the antiepileptic activity and ameliorates the metabolic changes associated with pentylenetetrazole kindling in rats treated with valproic acid.
Topics: Animals; Anticonvulsants; Aorta; Biomarkers; Blood Glucose; Drug Synergism; Epilepsy; Hippocampus; I | 2017 |
Comparison of LC-MS/MS vs chemiluminescent microparticle immunoassay in measuring the valproic acid concentration in plasma of epilepsy patients in a new perspective.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Cell Line; Child; Child, Preschool; Chr | 2018 |
An investigation of the characteristics of outpatients with epilepsy and antiepileptic drug utilization in a multicenter cross-sectional study in China.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; China; Cross-Sectional Studies; Drug Combin | 2017 |
Drug interaction between valproic acid and carbapenems in patients with epileptic seizures.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anticonvulsants; Bacterial Infections; Carbap | 2017 |
Associations of CYP2C9 and CYP2A6 Polymorphisms with the Concentrations of Valproate and its Hepatotoxin Metabolites and Valproate-Induced Hepatotoxicity.
Topics: Adolescent; Adult; Alleles; Anticonvulsants; Biotransformation; Chemical and Drug Induced Liver Inju | 2017 |
Hemodiafiltration and high-flux hemodialysis significantly reduce serum valproate levels inducing epileptic seizures: case report.
Topics: Adult; Epilepsy; Female; Hemodiafiltration; Humans; Levetiracetam; Piracetam; Renal Dialysis; Valpro | 2008 |
[Influence of age, body weight and dose on sodium valproate plasma concentrations in children with epilepsy].
Topics: Age Factors; Anticonvulsants; Body Weight; Child; Child, Preschool; Epilepsy; Female; Humans; Infant | 2008 |
Valproate teratogenicity and epilepsy syndrome.
Topics: Abnormalities, Drug-Induced; Age of Onset; Analysis of Variance; Anticonvulsants; Dose-Response Rela | 2008 |
States of serum leptin and insulin in children with epilepsy: risk predictors of weight gain.
Topics: Adolescent; Age Factors; Anticonvulsants; Body Mass Index; Carbamazepine; Case-Control Studies; Chil | 2009 |
Antiepileptic drug utilization in children from 1997-2005--a study from the Netherlands.
Topics: Anticonvulsants; Carbamazepine; Child; Databases, Factual; Drug Utilization; Epilepsy; Female; Human | 2008 |
Drug-induced pertubation of the aminothiol redox-status in patients with epilepsy: improvement by B-vitamins.
Topics: Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Cysteine; Dipeptides; Drug Evaluation; | 2008 |
Tetramethylcyclopropyl analogue of the leading antiepileptic drug, valproic acid: evaluation of the teratogenic effects of its amide derivatives in NMRI mice.
Topics: Abnormalities, Drug-Induced; Amides; Animals; Anticonvulsants; Benzenesulfonamides; Cyclopropanes; D | 2008 |
DNA topoisomerase I inhibitors ameliorate seizure-like behaviors and paralysis in a Drosophila model of epilepsy.
Topics: Analysis of Variance; Animals; Animals, Genetically Modified; Bromates; Camptothecin; Disease Models | 2008 |
Clonally expanded mitochondrial DNA mutations in epileptic individuals with mutated DNA polymerase gamma.
Topics: Adolescent; Anticonvulsants; Brain; Child; Child, Preschool; Diffuse Cerebral Sclerosis of Schilder; | 2008 |
Lack of valproic acid-associated weight gain in prepubertal children.
Topics: Adolescent; Anticonvulsants; Body Height; Body Mass Index; Body Weight; Carbamazepine; Child; Child, | 2008 |
Perspectives on interactions between antiepileptic drugs (AEDs) and antimicrobial agents.
Topics: Aged; Anti-Infective Agents; Anticonvulsants; Brain Abscess; Drug Interactions; Epilepsy; Female; He | 2008 |
Association of lamotrigine and valproate in refractory epilepsies of children and adolescents.
Topics: Adolescent; Age Distribution; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; E | 2008 |
The effects of biotin supplementation on serum and liver tissue biotinidase enzyme activity and alopecia in rats which were administrated to valproic acid.
Topics: Alopecia; Animals; Anticonvulsants; Avitaminosis; Biotin; Biotinidase; Biotinidase Deficiency; Dieta | 2009 |
Does ghrelin really increase in epileptic children treated with valproate?
Topics: Anticonvulsants; Child; Clinical Laboratory Techniques; Epilepsy; Ghrelin; Humans; Molecular Weight; | 2008 |
The influence of valproic acid treatment on hair and serum zinc levels and serum biotinidase activity.
Topics: Alopecia; Anticonvulsants; Biotinidase; Child; Child, Preschool; Epilepsy; Female; Hair; Humans; Mal | 2009 |
Effect of phenytoin and valproic acid therapy on serum lipid levels and liver function tests.
Topics: Anticonvulsants; Case-Control Studies; Child; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Epile | 2008 |
Effect of a manually generated laboratory comment on requesting and performance of valproate assays.
Topics: Anticonvulsants; Drug Monitoring; Epilepsy; Humans; Unnecessary Procedures; Valproic Acid | 2008 |
Thyroid hormones in children with epilepsy during long-term administration of carbamazepine and valproate.
Topics: Anticonvulsants; Carbamazepine; Child; Drug Administration Schedule; Epilepsy; Female; Humans; Linea | 2009 |
Valproate induced non hepatic hyperammonaemic encephalopathy (VNHE)--a study from tertiary care referral university hospital, north India.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Hyperam | 2008 |
The role of epilepsy in early language development in a child with a congenital lesion in the right hemisphere.
Topics: Anticonvulsants; Brain; Child; Cognition Disorders; Electroencephalography; Epilepsy; Functional Lat | 2008 |
Body mass index and serum lipid changes during treatment with valproic acid in children with epilepsy.
Topics: Age Factors; Blood Glucose; Body Mass Index; Child, Preschool; Cholesterol; Epilepsy; Female; Follow | 2009 |
Population pharmacokinetics of valproate in Mexican children with epilepsy.
Topics: Adolescent; Anticonvulsants; Body Weight; Child; Child, Preschool; Dose-Response Relationship, Drug; | 2008 |
First-drug treatment failures in children newly diagnosed with epilepsy.
Topics: Adolescent; Age Factors; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; | 2009 |
Thrombophilic risk factors in epileptic children treated with valproic Acid.
Topics: Adolescent; Anticonvulsants; Antithrombin III; Blood Coagulation Factors; Child; Child, Preschool; E | 2009 |
[Valproate treatment during pregnancy: description of four cases with foetal valproate syndrome].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child; Child, Preschool; Developmental Disabilities; E | 2009 |
Nonalcoholic fatty liver disease during valproate therapy.
Topics: Anticonvulsants; Body Mass Index; Child; Epilepsy; Fatty Liver; Fatty Liver, Alcoholic; Female; Huma | 2009 |
[Influence of the antagonist of adenosine A1 receptors, 8-cyclopentyl-1 ,3-dipropylxanthine, upon the anticonvulsant activity of antiepileptic drugs in mice].
Topics: Adenosine A1 Receptor Antagonists; Animals; Anticonvulsants; Brain; Drug Interactions; Epilepsy; Mal | 2008 |
Bone metabolism alteration on antiepileptic drug therapy.
Topics: Alkaline Phosphatase; Anticonvulsants; Bone and Bones; Carbamazepine; Child; Child, Preschool; Epile | 2009 |
[Meropenem and valproic acid. An interaction to remember].
Topics: Anti-Bacterial Agents; Anticonvulsants; Drug Interactions; Epilepsy; Female; Humans; Infant; Meropen | 2009 |
Pharmacokinetic modeling of carbamazepine based on clinical data from Serbian epileptic patients.
Topics: Adult; Age Factors; Algorithms; Anticonvulsants; Biological Availability; Carbamazepine; Child; Data | 2008 |
Long-term effects of valproic acid on reproductive endocrine functions in Turkish women with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Hype | 2009 |
Weight gain in children treated with valproate.
Topics: Adolescent; Anticonvulsants; Body Mass Index; Child; Child, Preschool; Epilepsy; Female; Humans; Lon | 2009 |
Effects of epilepsy and valproic acid on oxidant status in children with idiopathic epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Erythrocytes; Female; Glutathione Pe | 2009 |
Commentary to: "Evaluation of serum lipids and carotid artery intima media thickness in epileptic children treated with valproic acid".
Topics: Age Factors; Anticonvulsants; Carotid Stenosis; Child; Endothelial Cells; Epilepsy; Folic Acid; Homo | 2009 |
Valproate and lamotrigine level variation with menstrual cycle phase and oral contraceptive use.
Topics: Adolescent; Adult; Anticonvulsants; Body Mass Index; Contraceptives, Oral, Combined; Drug Interactio | 2009 |
Drug treatment of epilepsy in the century of the ILAE: the second 50 years, 1959-2009.
Topics: Advertising; Anticonvulsants; Epilepsy; History, 20th Century; History, 21st Century; Humans; Nation | 2009 |
Changing trends in antiepileptic drug prescribing in girls of child-bearing potential.
Topics: Abnormalities, Drug-Induced; Adolescent; Anticonvulsants; Carbamazepine; Child; Contraceptive Agents | 2009 |
[When a seizure occurs...].
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Fructose; Humans | 2009 |
[Cognitive impairment and parkinsonism due to use of sodium valproate].
Topics: Aged; Anticonvulsants; Cognition Disorders; Epilepsy; Humans; Male; Parkinson Disease, Secondary; Re | 2009 |
An experimental design for finding of minimum dosage of carbamazepine and valproate in preventing of seizure attacks.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Dose-Response Relationship, Drug; Drug Dosage Cal | 2009 |
Valproic acid delayed release (Stavzor).
Topics: Anticonvulsants; Capsules; Chemistry, Pharmaceutical; Delayed-Action Preparations; Epilepsy; Humans; | 2009 |
Interaction of tiagabine with valproate in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves.
Topics: Animals; Anticonvulsants; Brain Chemistry; Convulsants; Dose-Response Relationship, Drug; Drug Inter | 2009 |
Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs.
Topics: Adult; Anticonvulsants; Carbamazepine; Child, Preschool; Cognition; Developmental Disabilities; Dose | 2009 |
A novel system allowing long-term simultaneous video-electroencephalography recording, drug infusion and blood sampling in rats.
Topics: Animals; Anticonvulsants; Blood Specimen Collection; Catheterization; Disease Models, Animal; Drug D | 2009 |
Epilepsy in Angelman syndrome: a questionnaire-based assessment of the natural history and current treatment options.
Topics: Adolescent; Adult; Angelman Syndrome; Anticonvulsants; Child; Child, Preschool; Clonazepam; Comorbid | 2009 |
Valproate-associated coagulopathies in children during short-term treatment.
Topics: Adolescent; Anticonvulsants; Biomarkers; Blood Coagulation Disorders; Blood Coagulation Factors; Blo | 2009 |
Pregnancy, delivery, and outcome for the child in maternal epilepsy.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Apgar Score; Birth Weight; Congenital Abnormali | 2009 |
[Fetal malformations in women with epilepsy].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Bulgaria; Carbamazepine; Epilepsy; Female; Humans; Inf | 2009 |
Effectiveness of the first antiepileptic drug in the treatment of pediatric epilepsy.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Fructose; Humans; Retrospective S | 2009 |
Stupor and fast activity on electroencephalography in a child treated with valproate.
Topics: Brain; Child, Preschool; Electroencephalography; Epilepsy; Female; GABA Agents; Humans; Stupor; Valp | 2009 |
Which is the best anti-convulsant drug for the treatment of epilepsy in psoriatic or other Th1 mediated skin disease patients?
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Interleukin-2; NF-kappa B; Psoriasis; Th1 Cells; T | 2009 |
A cocaine body packer case report: clinical and forensic aspects.
Topics: Anticonvulsants; Cocaine; Crime; Digestive System; Epilepsy; Fatal Outcome; Foreign Bodies; Forensic | 2009 |
Poor applicability of estimation method for adults to calculate unbound serum concentrations of valproic acid in epileptic neonates and infants.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Child, Preschool; Drug Monitoring; Epilepsy; | 2009 |
Ring chromosome 20 syndrome: a link between epilepsy onset and neuropsychological impairment in three children.
Topics: Adult; Age of Onset; Anticonvulsants; Child; Chromosomes, Human, Pair 20; Cognition Disorders; Comor | 2009 |
Isobolographic characterization of interactions of levetiracetam with the various antiepileptic drugs in the mouse 6 Hz psychomotor seizure model.
Topics: Animals; Anticonvulsants; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug | 2009 |
A case of fetal valproate syndrome with new features expanding the phenotype.
Topics: Abnormalities, Multiple; Anticonvulsants; Epilepsy; Female; Fetus; Humans; Infant; Phenotype; Pregna | 2009 |
Acute pancreatitis associated to the use of valproic acid.
Topics: Acute Disease; Child; Epilepsy; Female; Humans; Pancreatitis; Valproic Acid | 2009 |
Once daily monotherapy with prolonged-release valproate minitablets given in the evening--a chronopharmacological study.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Chronobiology Phenomena; Delayed-Action Prepa | 2009 |
Na VPA-induced acute ischemic stroke in an epileptic patient with methylenetetrahydrofolate reductase gene polymorphism.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Brain; Brain Ischemia; Epilepsy; Humans; Hyperhomo | 2009 |
Cognitive function after fetal exposure to antiepileptic drugs.
Topics: Anticonvulsants; Child, Preschool; Confounding Factors, Epidemiologic; Developmental Disabilities; E | 2009 |
Improved seizure control by alternating therapy of levetiracetam and valproate in epileptic rats.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Disease Models, Animal; Drug Administration Schedule; Drug | 2010 |
The metabolic syndrome in overweight epileptic patients treated with valproic acid.
Topics: Adolescent; Anticonvulsants; Body Mass Index; Cardiovascular Diseases; Child; Comorbidity; Dyslipide | 2010 |
A 12-month longitudinal study of calcium metabolism and bone turnover during valproate monotherapy.
Topics: Adolescent; Anticonvulsants; Bone and Bones; Calcium; Case-Control Studies; Diet; Epilepsy; Exercise | 2010 |
Nitric oxide, lipid peroxidation, and antioxidant enzyme levels in epileptic children using valproic acid.
Topics: Anticonvulsants; Antioxidants; Biomarkers; Catalase; Child; Child, Preschool; Enzyme Assays; Enzymes | 2009 |
Chronic antiepileptic monotherapy, bone metabolism, and body composition in non-institutionalized children.
Topics: Anthropometry; Anticonvulsants; Body Composition; Body Height; Body Mass Index; Body Weight; Carbama | 2010 |
Is asymmetric dimethylarginine responsible for the vascular events in patients under antiepileptic drug treatment?
Topics: Adult; Anticonvulsants; Arginine; Arterial Occlusive Diseases; Carbamazepine; Drug Monitoring; Epile | 2009 |
Effects of CYP2C19 and CYP2C9 genotypes on pharmacokinetic variability of valproic acid in Chinese epileptic patients: nonlinear mixed-effect modeling.
Topics: Adult; Aged; Antimanic Agents; Aryl Hydrocarbon Hydroxylases; China; Cytochrome P-450 CYP2C19; Cytoc | 2009 |
Ghrelin levels are reduced in prepubertal epileptic children under treatment with carbamazepine or valproic acid.
Topics: Age Factors; Anticonvulsants; Body Height; Body Mass Index; Carbamazepine; Child; Depression, Chemic | 2010 |
Introduction of intravenous formulations of the antiepileptic drugs levetiracetam and valproate to the Australian market.
Topics: Anticonvulsants; Australia; Epilepsy; Humans; Injections, Intravenous; Marketing of Health Services; | 2009 |
Unilateral lung agenesis: coincidence or association with maternal valproate therapy?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Lung; Male; | 2009 |
Once-daily dosing is appropriate for extended-release divalproex over a wide dose range, but not for enteric-coated, delayed-release divalproex: evidence via computer simulations and implications for epilepsy therapy.
Topics: Anticonvulsants; Area Under Curve; Computer Simulation; Delayed-Action Preparations; Dose-Response R | 2009 |
A prospective study of cognitive fluency and originality in children exposed in utero to carbamazepine, lamotrigine, or valproate monotherapy.
Topics: Analysis of Variance; Anticonvulsants; Carbamazepine; Child, Preschool; Cognition; Creativity; Epile | 2009 |
Metabolic alterations during valproic acid treatment: a prospective study.
Topics: Adolescent; Androgens; Anticonvulsants; Blood Glucose; Body Mass Index; Child; Child, Preschool; Cho | 2009 |
Effect of pharmacist participation in the health care team on therapeutic drug monitoring utilization for antiepileptic drugs.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Chi-Square Distribution; | 2009 |
Syndrome of inappropriate antidiuretic hormone secretion (SIADH) or hyponatraemia associated with valproic Acid: four case reports from the Netherlands and a case/non-case analysis of vigibase.
Topics: Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Anticonvulsants; Databases, Factua | 2010 |
Analytical interference of carbamazepine on the Abbott TDx and Abbott Axsym tricyclic antidepressant assays.
Topics: Adult; Anticonvulsants; Antidepressive Agents, Tricyclic; Carbamazepine; Cross Reactions; Drug Monit | 2009 |
Inhibition of long-term potentiation by valproic acid through modulation of cyclic AMP.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Cyclic AMP; Cyclic AMP-Dependent Protein Kina | 2010 |
[Effects of valproate on male reproductive functions].
Topics: Anticonvulsants; Antimanic Agents; Epilepsy; Female; Genitalia, Male; Humans; Male; Menstrual Cycle; | 2009 |
Changing patterns of antiepileptic drug use in pregnant Australian women.
Topics: Anticonvulsants; Australia; Congenital Abnormalities; Epilepsy; Female; Humans; Linear Models; Pract | 2010 |
Effects of levetiracetam and valproic acid monotherapy on sex-steroid hormones in prepubertal children--results from a pilot study.
Topics: Analysis of Variance; Anticonvulsants; Child; Cohort Studies; Cross-Sectional Studies; Epilepsy; Fem | 2010 |
Valproic acid: long-term effects on children exposed in utero.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Cohort Studies; Contraindications; Dose | 2009 |
Adverse effects of carbamazepine, phenytoin, valproate and lamotrigine monotherapy in epileptic adult Chinese patients.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; China; Drug Eruptions; Epilepsy; Female; Hu | 2010 |
Effects of the antiepileptic drugs on peripheral nerve function.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Female; Fructose; Humans; Male; Median Nerve; Neural Condu | 2010 |
Hippocampal synaptic plasticity, memory, and epilepsy: effects of long-term valproic acid treatment.
Topics: Animals; Anticonvulsants; Behavior, Animal; Biophysics; Calcium-Calmodulin-Dependent Protein Kinase | 2010 |
Levetiracetam inhibits interleukin-1 beta inflammatory responses in the hippocampus and piriform cortex of epileptic rats.
Topics: Animals; Anticonvulsants; Astrocytes; Chronic Disease; Epilepsy; Gliosis; Hippocampus; Interleukin-1 | 2010 |
The influence of cytochrome oxidase CYP2A6, CYP2B6, and CYP2C9 polymorphisms on the plasma concentrations of valproic acid in epileptic patients.
Topics: Adolescent; Adult; Alleles; Aryl Hydrocarbon Hydroxylases; Child; Child, Preschool; China; Cytochrom | 2010 |
POLG DNA testing as an emerging standard of care before instituting valproic acid therapy for pediatric seizure disorders.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diffuse Cerebral Sclerosis of Schilder; DNA Mu | 2010 |
Valproate-induced hyperammonemic encephalopathy, rapidly improved by i.v. carnitine and glucose/thiamine.
Topics: Aged; Ammonia; Anticonvulsants; Brain Diseases, Metabolic; Carnitine; Dose-Response Relationship, Dr | 2010 |
Quantitative analysis of motor performance in epilepsy patients treated with valproate.
Topics: Adult; Aged; Anticonvulsants; Epilepsy; Female; Humans; Male; Middle Aged; Motor Skills; Reaction Ti | 2010 |
Long-term efficacy of valproate versus lamotrigine in treatment of idiopathic generalized epilepsies in children and adolescents.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Lamotrigine; Male; T | 2010 |
TrkB/BDNF-dependent striatal plasticity and behavior in a genetic model of epilepsy: modulation by valproic acid.
Topics: Analysis of Variance; Animals; Anticonvulsants; Avoidance Learning; Brain-Derived Neurotrophic Facto | 2010 |
Valproic acid in the complex therapy of malignant tumors.
Topics: Acetylation; Angiogenesis Inhibitors; Apoptosis; Azacitidine; Cell Cycle; Clinical Trials as Topic; | 2010 |
Growth hormone levels in children and adolescents with epilepsy.
Topics: Adolescent; Anthropometry; Body Weight; Carbamazepine; Chi-Square Distribution; Child; Developmental | 2010 |
Fanconi syndrome caused by valproic acid.
Topics: Adolescent; Anticonvulsants; Child; Epilepsy; Fanconi Syndrome; Female; Humans; Male; Time Factors; | 2010 |
Valproic acid-induced pancreatitis in an adult.
Topics: Adult; Anticonvulsants; Epilepsy; Humans; Male; Pancreatitis; Valproic Acid | 2010 |
Antiepileptic drugs modify power of high EEG frequencies and their neural generators.
Topics: Adolescent; Adult; Anticonvulsants; Brain Waves; Carbamazepine; Electroencephalography; Epilepsy; Fe | 2010 |
Absence of a general association between ABCB1 genetic variants and response to antiepileptic drugs in epilepsy patients.
Topics: Adolescent; Adult; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Casse | 2010 |
Late-onset nocturnal intractable seizure during sleep: what is the origin?
Topics: Anticonvulsants; Clonazepam; Epilepsy; Follow-Up Studies; Humans; Male; Middle Aged; Polysomnography | 2010 |
Pharmacokinetics and clinical application of intravenous valproate in Thai epileptic children.
Topics: Adolescent; Ammonia; Anticonvulsants; Child; Child, Preschool; Cross-Sectional Studies; Epilepsy; Fe | 2011 |
Effect of CPS14217C>A genotype on valproic-acid-induced hyperammonemia.
Topics: Adolescent; Adult; Age Distribution; Analysis of Variance; Anticonvulsants; Carbamoyl-Phosphate Synt | 2010 |
Modification in body weight associated with antiepileptic drugs.
Topics: Adult; Anticonvulsants; Body Mass Index; Carbamazepine; Epilepsy; Female; Humans; Male; Valproic Aci | 2010 |
[Pathogenetic basis of pharmaceutical hepatitis induced by depakine in children].
Topics: Anticonvulsants; Biliary Dyskinesia; Case-Control Studies; Chemical and Drug Induced Liver Injury; C | 2009 |
Gastaut type-idiopathic childhood occipital epilepsy and childhood absence epilepsy: a clinically significant association?
Topics: Anticonvulsants; Blindness; Child; Electroencephalography; Epilepsy; Epilepsy, Absence; Ethosuximide | 2010 |
[Characteristics of the children with epilepsy followed in the Marrakech University Hospital].
Topics: Adolescent; Age of Onset; Anticonvulsants; Cerebral Palsy; Child; Child, Preschool; Consanguinity; E | 2010 |
BsmI vitamin D receptor's polymorphism and bone mineral density in men and premenopausal women on long-term antiepileptic therapy.
Topics: Absorptiometry, Photon; Adolescent; Adult; Alleles; Anticonvulsants; Bone Density; Calcium, Dietary; | 2011 |
Valproate and risk of fracture in Rett syndrome.
Topics: Adolescent; Adult; Anticonvulsants; Australia; Child; Child, Preschool; Drug Administration Schedule | 2010 |
Role of parental risk factors in the aetiology of isolated non-syndromic metopic craniosynostosis.
Topics: Anticonvulsants; Chi-Square Distribution; Craniosynostoses; Epilepsy; Female; Fertility Agents, Fema | 2010 |
Characterization, using comparative proteomics, of differentially expressed proteins in the hippocampus of the mesial temporal lobe of epileptic rats following treatment with valproate.
Topics: Adolescent; Adult; Animals; Child; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Ep | 2011 |
[Effect of UGTIA6 A541G genetic polymorphism on the metabolism of valproic acid in Han epileptic children from Henan].
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; China; Epilepsy; Glucuronosyltransferase; Huma | 2010 |
[Changes of body mass index and plasma galanin in children with epilepsy following valproate sodium treatment].
Topics: Adolescent; Anticonvulsants; Body Mass Index; Child; Child, Preschool; Epilepsy; Female; Galanin; Hu | 2010 |
Effects of valproate and carbamazepine monotherapy on neuroactive steroids, their precursors and metabolites in adult men with epilepsy.
Topics: Adult; Androstanes; Anticonvulsants; Carbamazepine; Epilepsy; Gas Chromatography-Mass Spectrometry; | 2010 |
Effect of valproic acid treatment on copper availability in adult epileptic patients.
Topics: Adult; Anticonvulsants; Case-Control Studies; Ceruloplasmin; Copper; Epilepsy; Humans; Valproic Acid | 2010 |
Valproate-induced reversible hemichorea.
Topics: Anticonvulsants; Brain; Chorea; Epilepsy; Functional Laterality; Humans; Magnetic Resonance Imaging; | 2010 |
Early cognitive development in children born to women with epilepsy: a prospective report.
Topics: Age Factors; Anticonvulsants; Child; Child of Impaired Parents; Cognition; Cognition Disorders; Deve | 2010 |
Quality of life and treatment satisfaction in Spanish epilepsy patients on monotherapy with lamotrigine or valproic acid.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Lamotrigine; Male; Patient Satisfaction; Quality o | 2010 |
Retrospective analysis of the effectiveness of first-line antiepileptic drugs for generalized onset and unclassified epileptic seizures in Chinese children.
Topics: Age of Onset; Anticonvulsants; Asian People; Carbamazepine; Child; Child, Preschool; Epilepsy; Femal | 2011 |
Effects of AEDs on biomarkers in people with epilepsy: CRP, HbA1c and eGFR.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Biomarkers; C-Reactive Protein; Epilepsy; Female; G | 2010 |
Comparative pharmacodynamic and pharmacokinetic analysis of two anticonvulsant halo derivatives of 2,2,3,3-tetramethylcyclopropanecarboxamide, an amide of a cyclic analog of valproic acid.
Topics: Abnormalities, Drug-Induced; Amides; Analgesics; Animals; Anticonvulsants; Cyclopropanes; Disease Mo | 2010 |
Is lamotrigine a significant human teratogen? Observations from the Australian Pregnancy Register.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Australia; Congenital Abnormalities; Dose-Response Rel | 2010 |
Drug treatment failures and effectivity in children with newly diagnosed epilepsy.
Topics: Adolescent; Age of Onset; Anticonvulsants; Carbamazepine; Chi-Square Distribution; Child; Child, Pre | 2010 |
[Effect of Chaihu Shugan Tang on excitability in different brain regions of pentylenetetrazole-kindled chronic epileptic rats].
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Aspartic Acid; Brain; Chronic Disease; Deoxyglucose; Disease | 2010 |
Correlation between EEG abnormalities and symptoms of autism spectrum disorder (ASD).
Topics: Adolescent; Age of Onset; Aging; Anticonvulsants; Asperger Syndrome; Autistic Disorder; Brain Mappin | 2010 |
Age and comedications influence levetiracetam pharmacokinetics in children.
Topics: Adolescent; Age Factors; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Interactions; | 2010 |
Blood ammonia levels in epileptic children on 2 dose ranges of valproic acid monotherapy: a cross-sectional study.
Topics: Ammonia; Anticonvulsants; Child; Child, Preschool; Cross-Sectional Studies; Epilepsy; Fluorescence P | 2011 |
Oxidative stress in children affected by epileptic encephalopathies.
Topics: Biomarkers; Blood Proteins; Child; Child, Preschool; Epilepsy; F2-Isoprostanes; Female; Humans; Infa | 2011 |
A 6-month prospective study on efficacy safety and QOL profiles of extended-release formulation of valproate in patients with epilepsy.
Topics: Adolescent; Adult; Aged; Chemistry, Pharmaceutical; Child; Delayed-Action Preparations; Epilepsy; Fe | 2011 |
Transplacental genotoxicity of antiepileptic drugs: animal model and pilot study on mother/newborn cohort.
Topics: Adult; Animals; Animals, Newborn; Anticonvulsants; Cohort Studies; Epilepsy; Female; Humans; Infant, | 2010 |
Drug-to-drug interaction between sodium valproate and trihexyphenidyl in a child with extrapyramidal cerebral palsy and epilepsy.
Topics: Anticonvulsants; Cerebral Palsy; Child, Preschool; Dose-Response Relationship, Drug; Drug Interactio | 2011 |
Factors influencing valproate pharmacokinetics in children and adults.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Body Weight; Carbamazepine; Child; Child, Pre | 2010 |
Circulating levels of allopregnanolone, a neuroactive steroid, and leptin during treatment with valproic acid in children with epilepsy.
Topics: Anticonvulsants; Child; Epilepsy; Female; Humans; Immunoassay; Leptin; Male; Obesity; Pregnanolone; | 2011 |
Predictability of individualized dosage regimens of carbamazepine and valproate mono- and combination therapy.
Topics: Adult; Aged; Anticonvulsants; Bayes Theorem; Carbamazepine; Chronic Disease; Databases, Factual; Dem | 2011 |
[Epileptic spasms without hypsarrhythmia. A new case report and review of the literature].
Topics: Anticonvulsants; Diagnosis, Differential; Electroencephalography; Epilepsy; Female; Humans; Infant; | 2010 |
Valproic acid and phenobarbital blood levels during the first month of treatment with the ketogenic diet.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Combined Modality Therapy; Diet, Ketogenic; Ep | 2010 |
The Australian brain and cognition and antiepileptic drugs study: IQ in school-aged children exposed to sodium valproate and polytherapy.
Topics: Anticonvulsants; Australia; Brain; Child; Cognition; Comprehension; Drug Therapy, Combination; Epile | 2011 |
Fluctuating and constant valproate administration gives equivalent seizure control in rats with genetic and acquired epilepsy.
Topics: Animals; Epilepsy; Epilepsy, Absence; Female; Infusion Pumps; Male; Rats; Rats, Mutant Strains; Valp | 2011 |
Effects of breastfeeding in children of women taking antiepileptic drugs.
Topics: Adult; Anticonvulsants; Breast Feeding; Carbamazepine; Child, Preschool; Cognition; Epilepsy; Female | 2010 |
Serum asymmetric dimethylarginine (ADMA), homocysteine, vitamin B(12), folate levels, and lipid profiles in epileptic children treated with valproic acid.
Topics: Adolescent; Anticonvulsants; Arginine; Biomarkers; Case-Control Studies; Child; Child, Preschool; Ch | 2011 |
Valproic acid-associated acute liver failure in children: case report and analysis of liver transplantation outcomes in the United States.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Follow-Up Studies; Humans; I | 2011 |
A preliminary investigation on the possible association between diminished copper availability and non-alcoholic fatty liver disease in epileptic patients treated with valproic acid.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Biological Availability; Copper; Epilep | 2011 |
Evaluation of valproate effects on acylcarnitine in epileptic children by LC-MS/MS.
Topics: Adolescent; Anticonvulsants; Carnitine; Child; Child, Preschool; Chromatography, Liquid; Epilepsy; F | 2011 |
Empirical approach for improved estimation of unbound serum concentrations of valproic acid in epileptic infants by considering their physical development.
Topics: Anticonvulsants; Drug Monitoring; Epilepsy; Female; Humans; Infant; Infant, Newborn; Male; Nonlinear | 2011 |
The effect of lamotrigine on valproic acid concentrations.
Topics: Adolescent; Child; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Epilepsy; Female; H | 2011 |
Thinking beyond the obvious: hepatotoxicity secondary to idiosyncratic depakote toxicity.
Topics: Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Monitoring; Epilepsy; Female; H | 2012 |
Study of epileptiform activity in cerebral ganglion of mud crab Scylla serrata.
Topics: Animals; Anticonvulsants; Brachyura; Convulsants; Disease Models, Animal; Epilepsy; gamma-Aminobutyr | 2011 |
Valproate attenuates the risk of myocardial infarction in patients with epilepsy: a nationwide cohort study.
Topics: Adult; Aged; Anticonvulsants; Case-Control Studies; Cause of Death; Chi-Square Distribution; Cohort | 2011 |
Nonalcoholic fatty liver disease in adolescents receiving valproic acid.
Topics: Adolescent; Alanine Transaminase; Anticonvulsants; Blood Pressure; Body Weight; Chemical and Drug In | 2011 |
Child development following in utero exposure: levetiracetam vs sodium valproate.
Topics: Anticonvulsants; Child Development; Child, Preschool; Cognition; Epilepsy; Female; Humans; Infant; L | 2011 |
Neonatal episodic hypoglycemia: a finding of valproic acid withdrawal.
Topics: Anticonvulsants; Epilepsy; Female; Glucose; Humans; Hypoglycemia; Infant, Newborn; Infant, Newborn, | 2010 |
Lack of association of ABCB1 and PXR polymorphisms with response to treatment in epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Asian People; ATP Binding Cassette Transporter, Subfamily B; ATP | 2011 |
Valproic acid modulates superoxide dismutase, uric acid-independent FRAP and zinc in blood of adult epileptic patients.
Topics: Adult; Epilepsy; Female; Ferric Compounds; Humans; Male; Oxidation-Reduction; Superoxide Dismutase; | 2011 |
Real-time, in vivo monitoring and pharmacokinetics of valproic acid via a novel biomarker in exhaled breath.
Topics: Biomarkers; Breath Tests; Epilepsy; Exhalation; Humans; Monitoring, Physiologic; Protein Binding; Sp | 2011 |
Association between ABCB1 polymorphism and response to sodium valproate treatment in Malaysian epilepsy patients.
Topics: Adult; Alleles; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette | 2011 |
Neurodevelopment of children exposed in utero to lamotrigine, sodium valproate and carbamazepine.
Topics: Anticonvulsants; Carbamazepine; Case-Control Studies; Child, Preschool; Developmental Disabilities; | 2011 |
Increase in non-transferrin bound iron and the oxidative stress status in epilepsy patients treated using valproic acid monotherapy.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Iron; Lipid Peroxidation; Male; Oxidative Stress; | 2011 |
[Staring episodes in children with developmental disorders: epilepsy or behaviour?].
Topics: Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Child; Child Behavior; Diagnosis, | 2011 |
Folie à deux: double case-report of shared delusions with a fatal outcome.
Topics: Adult; Anticonvulsants; Antipsychotic Agents; Benzodiazepines; Clozapine; Combined Modality Therapy; | 2011 |
Drug-resistant epilepsia and fulminant valproate liver toxicity. Alpers-Huttenlocher syndrome in two children confirmed post mortem by identification of p.W748S mutation in POLG gene.
Topics: Amino Acid Substitution; Child; Diffuse Cerebral Sclerosis of Schilder; DNA Polymerase gamma; DNA-Di | 2011 |
The effect of valproate therapy on thrombin generation determined by calibrated automated thrombography.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Female; F | 2011 |
Lack of association of ABCB1 haplotypes on five loci with response to treatment in epilepsy.
Topics: Alleles; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transp | 2011 |
The relationship between UGT1A4 polymorphism and serum concentration of lamotrigine in patients with epilepsy.
Topics: Adult; Amino Acid Substitution; Anticonvulsants; Chromatography, High Pressure Liquid; Dose-Response | 2011 |
No effect of co-administered antiepileptic drugs on in-vivo protein binding parameters of valproic acid in patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Fe | 2011 |
Pharmacokinetic and pharmacodynamic interactions of valproate, phenytoin, phenobarbitone and carbamazepine with curcumin in experimental models of epilepsy in rats.
Topics: Animals; Anticonvulsants; Carbamazepine; Curcumin; Disease Models, Animal; Drug Interactions; Drug T | 2011 |
Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epile | 2011 |
Serum insulin, cortisol, leptin, neuropeptide Y, galanin and ghrelin levels in epileptic children receiving valproate.
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Galanin; Ghrelin; Humans; Hydrocortisone; Insulin; Le | 2011 |
Novel characterization of drug-associated pancreatitis in children.
Topics: Acute Disease; Adolescent; Adrenal Cortex Hormones; Child; Child, Preschool; Comorbidity; Crohn Dise | 2011 |
Valproic Acid related metabolic syndrome in patients with epilepsy.
Topics: Adult; Anticonvulsants; Blood Glucose; Body Mass Index; Carbamazepine; Cholesterol, HDL; Epilepsy; F | 2011 |
Clinical and pharmacy utilization outcomes with brand to generic antiepileptic switches in patients with epilepsy.
Topics: Anticonvulsants; Drug Substitution; Drugs, Generic; Emergency Service, Hospital; Epilepsy; Female; H | 2011 |
Hyperammonemic encephalopathy related to valproate, phenobarbital, and topiramate synergism.
Topics: Drug Synergism; Drug Therapy, Combination; Epilepsy; Female; Fructose; Humans; Hyperammonemia; Middl | 2011 |
Levetiracetam compared to valproic acid: plasma concentration levels, adverse effects and interactions in aneurysmal subarachnoid hemorrhage.
Topics: Administration, Oral; Aged; Aneurysm, Ruptured; Anti-Bacterial Agents; Anticonvulsants; Biological A | 2011 |
Haematological side effects of antiepileptic drug treatment in patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Blood Platelets; Carbamazepine; Cross-Sectional Studies; Epileps | 2011 |
The neuroprotective effect of curcumin and Nigella sativa oil against oxidative stress in the pilocarpine model of epilepsy: a comparison with valproate.
Topics: Acetylcholinesterase; Animals; Curcumin; Epilepsy; Glutathione; Hippocampus; Lipid Peroxidation; Nig | 2011 |
Antiepileptic drug use during pregnancy: perinatal outcomes.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Carbamazepine; Cohort Studies; Drug | 2011 |
Association of genetic variants in six candidate genes with valproic acid therapy optimization.
Topics: Adult; Alleles; Anticonvulsants; DNA; Epilepsy; Epilepsy, Generalized; Female; Gene Frequency; Genet | 2011 |
Simple and accurate quantitative analysis of ten antiepileptic drugs in human plasma by liquid chromatography/tandem mass spectrometry.
Topics: Anticonvulsants; Calibration; Carbamazepine; Chromatography, Liquid; Drug Monitoring; Drug Stability | 2011 |
The consequences of valproate overdose.
Topics: Acid-Base Equilibrium; Acidosis, Lactic; Adult; Anticonvulsants; Carnitine; Drug Overdose; Epilepsy; | 2011 |
The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium.
Topics: Animals; Anticonvulsants; Dictyostelium; Disease Models, Animal; Dose-Response Relationship, Drug; E | 2012 |
The prescribing of antiepileptic drugs for pregnant Australian women.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Australia; Epilepsy; Female; Fetus; Humans; Log | 2012 |
[Effects of valproate sodium on pituitary gonadotropin in adolescent girls with epilepsy].
Topics: Adolescent; Anticonvulsants; Child; Epilepsy; Female; Gonadotropins, Pituitary; Humans; Valproic Aci | 2011 |
[Epilepsy in elderly].
Topics: Aged; Aged, 80 and over; Aging; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsies, | 2011 |
Acoustic startle hypersensitivity in Mceph mice and its effect on hippocampal excitability.
Topics: Acoustic Stimulation; Animals; Astrocytes; Epilepsy; Glial Fibrillary Acidic Protein; Hippocampus; K | 2011 |
A case of hyperammonaemic encephalopathy due to valproic acid.
Topics: Anticonvulsants; Epilepsy; Humans; Hyperammonemia; Male; Middle Aged; Neurotoxicity Syndromes; Valpr | 2011 |
Use of antiepileptic medications in pregnancy in relation to risks of birth defects.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Hu | 2011 |
Antiepleptic drug interactions: a clinical case demonstration.
Topics: Adolescent; Anticonvulsants; Brain; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epi | 2011 |
Valproate and lamotrigine in children and adolescents with drop attacks: follow-up after the first year.
Topics: Anticonvulsants; Benzodiazepines; Epilepsy; Female; Humans; Male; Triazines; Valproic Acid | 2011 |
Simultaneous determination of valproic acid and 2-propyl-4-pentenoic acid for the prediction of clinical adverse effects in Chinese patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Child; China; Chromatography, High Pressure Liquid; Epilepsy; Fa | 2012 |
Synthesis and anticonvulsant evaluation of dimethylethanolamine analogues of valproic acid and its tetramethylcyclopropyl analogue.
Topics: Animals; Anticonvulsants; Brain Waves; Convulsants; Cyclopropanes; Deanol; Disease Models, Animal; E | 2012 |
Investigating the role of zinc in a rat model of epilepsy.
Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Epilepsy; Hippocampus; Male; Pilocarpine | 2012 |
Cancer risk in people with epilepsy using valproate-sodium.
Topics: Adult; Causality; Comorbidity; Epilepsy; Female; Humans; Incidence; Male; Middle Aged; Neoplasms; Pr | 2012 |
Effects of long-term antiepileptic drug monotherapy on vascular risk factors and atherosclerosis.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Atherosclerosis; Blood Glucose; Carbamazepine; Carotid Art | 2012 |
[Effects of magnesium valproate on endocrine system and reproductive functions of female epileptics].
Topics: Adolescent; Adult; Child; Endocrine System; Epilepsy; Female; Follicle Stimulating Hormone; Humans; | 2011 |
Evaluation of subclinical hypothyroidism in ambulatory children with controlled epilepsy on valproate monotherapy.
Topics: Adolescent; Ambulatory Care; Antibodies; Anticonvulsants; Case-Control Studies; Child; Child, Presch | 2012 |
Superoxide dismutase 2 Val16Ala polymorphism is a risk factor for the valproic acid-related elevation of serum aminotransferases.
Topics: Adolescent; Adult; Aged; Alanine; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; M | 2012 |
Vulnerability of an epileptic case to psychosis: sodium valproate with lamotrigine, forced normalization, postictal psychosis or all?
Topics: Adult; Age of Onset; Anticonvulsants; Child; Drug Therapy, Combination; Electroencephalography; Epil | 2012 |
Valproate effects on generalized spike-wave discharges and photoparoxysmal response.
Topics: Anticonvulsants; Epilepsy; Humans; Photic Stimulation; Valproic Acid | 2011 |
The effects of antiepileptic drugs on the relationships between leptin levels and bone turnover in prepubertal children with epilepsy.
Topics: Anticonvulsants; Biomarkers; Bone Density; Bone Remodeling; Carbamazepine; Child; Child, Preschool; | 2011 |
Fasting insulin and HOMA-index changes in patients treated with valproic acid.
Topics: Adult; Blood Glucose; Body Mass Index; C-Peptide; Carbamazepine; Cholesterol, HDL; Epilepsy; Female; | 2011 |
Comparative efficacy of combination drug therapy in refractory epilepsy.
Topics: Anticonvulsants; Developmental Disabilities; Drug Therapy, Combination; Epilepsy; Female; Humans; La | 2012 |
[Lamotrigine add-on therapy for childhood-onset refractory epilepsy: comparison of the efficacy between 3 months and 6 months after initiation].
Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination | 2011 |
Apparent clearance of valproic acid in elderly epileptic patients: estimation of the confounding effect of albumin concentration.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Child; Epilepsy; Female; Humans; Male; | 2012 |
Anticonvulsant profile of caprylic acid, a main constituent of the medium-chain triglyceride (MCT) ketogenic diet, in mice.
Topics: Animals; Anticonvulsants; Brain; Caprylates; Dose-Response Relationship, Drug; Epilepsy; Male; Mice; | 2012 |
Analysis of acylcarnitine levels by tandem mass spectrometry in epileptic children receiving valproate and oxcarbazepine.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Carnitine; Child; Child, Preschool; Chromatography, High | 2011 |
[Epileptic asystole - a case report].
Topics: Anticonvulsants; Electroencephalography; Epilepsy; Female; Heart Arrest; Humans; Middle Aged; Pacema | 2012 |
[Neurology].
Topics: Antibodies, Monoclonal; Anticonvulsants; Atrial Fibrillation; Carbamates; Chronic Disease; Deep Brai | 2012 |
Long term effects of tetramine poisoning: an observational study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Anticonvulsants; Bridged-Ring Compounds; Charco | 2012 |
[Effects of sodium valproate on neutrophils' oxidative metabolism and oxidant status in children with idiopathic epilepsy].
Topics: Anticonvulsants; Antioxidants; Case-Control Studies; Catalase; Child; Child, Preschool; Epilepsy; Fe | 2011 |
Valproate and the risk for congenital malformations: Is formulation and dosage regime important?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complic | 2012 |
Thyroid hormones may contribute to vascular risk factors and atherosclerosis.
Topics: Anticonvulsants; Atherosclerosis; Carbamazepine; Carotid Artery, Common; Epilepsy; Female; Humans; M | 2012 |
Influence of UDP-glucuronosyltransferase polymorphisms on valproic acid pharmacokinetics in Chinese epilepsy patients.
Topics: Adult; Alleles; Anticonvulsants; Asian People; Carbamazepine; Epilepsy; Female; Glucuronosyltransfer | 2012 |
Characterization of glucose homeostasis and lipid profile in adult, seizure-free, epileptic patients in Asian population.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Asian People; Blood Glucose; Cholesterol, LDL; Cross-Secti | 2012 |
Economic evaluation of anti-epileptic drug therapies with specific focus on teratogenic outcomes.
Topics: Abnormalities, Drug-Induced; Adolescent; Anticonvulsants; Carbamazepine; Cost-Benefit Analysis; Epil | 2012 |
Seizure management at Auckland City Hospital Emergency Department between July and December 2009: time for a change?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Disease Management; Emer | 2012 |
Risk factors for hyperammonemia associated with valproic acid therapy in adult epilepsy patients.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Female; Humans | 2012 |
Prevalence, utilization, and costs of antiepileptic drugs for epilepsy in Germany--a nationwide population-based study in children and adults.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Databases, Factual; Epilepsy; German | 2012 |
Evaluation of the antiepileptic effect of curcumin and Nigella sativa oil in the pilocarpine model of epilepsy in comparison with valproate.
Topics: Amino Acids; Animals; Anticonvulsants; Behavior, Animal; Cerebral Cortex; Chromatography, High Press | 2012 |
Valproate induces epigenetic modifications in lymphomonocytes from epileptic patients.
Topics: Acetylation; Adult; Anticonvulsants; Case-Control Studies; DNA Methylation; Dose-Response Relationsh | 2012 |
The effect of combination therapy on the plasma concentrations of traditional antiepileptics: a retrospective study.
Topics: Adolescent; Adult; Age Factors; Aged; Analysis of Variance; Anticonvulsants; Carbamazepine; Drug Int | 2012 |
Subclinical hypothyroidism during valproic acid therapy in children and adolescents with epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Humans; Hypothyroidism; Severity of | 2012 |
Plasma leptin, neuropeptide Y, ghrelin, and adiponectin levels and carotid artery intima media thickness in epileptic children treated with valproate.
Topics: Adiponectin; Age Factors; Anticonvulsants; Blood Glucose; Body Mass Index; Carotid Intima-Media Thic | 2012 |
A retrospective study on the usage of antiepileptic drugs in Asian children from 2000 to 2009 in the largest pediatric hospital in Singapore.
Topics: Anticonvulsants; Asia; Child; Epilepsy; Female; History, 21st Century; Hospitals, Pediatric; Humans; | 2012 |
Correlation between plasma ammonia level and serum trough concentration of free valproic acid in patients with epilepsy.
Topics: Adolescent; Adult; Ammonia; Anticonvulsants; Asian People; Child; Child, Preschool; Epilepsy; Female | 2012 |
Hallucinations after withdrawal of valproic acid.
Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Hallucinations; Humans; Substance Withdr | 2012 |
Late adverse effects of the coadministration of valproate and lamotrigine.
Topics: Adolescent; Anticonvulsants; Ataxia; Child; Drug Therapy, Combination; Epilepsy; Female; Headache; H | 2012 |
Valproate-acid-induced cutaneous leukocytoclastic vasculitis.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Valproic Acid; Vasculitis, Leukocytoclastic, Cutan | 2012 |
Metabolic syndrome among Chinese obese patients with epilepsy on sodium valproate.
Topics: Adolescent; Adult; Anticonvulsants; Asian People; Epilepsy; Female; Humans; Male; Metabolic Syndrome | 2012 |
Development and validation of a bioanalytical LC-UV method with solid-phase extraction for determination of valproic acid in saliva.
Topics: Adolescent; Adult; Anticonvulsants; Biopharmaceutics; Calibration; Chromatography, High Pressure Liq | 2012 |
Sodium valproate for epilepsy in rural China: an efficacy and safety assessment in primary care.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Child; China; Epilepsy; Female; Follow- | 2012 |
Primary afterdischarge in organotypic hippocampal slice cultures: effects of standard antiepileptic drugs.
Topics: Action Potentials; Animals; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Epilepsy; H | 2012 |
Teratogenesis in repeated pregnancies in antiepileptic drug-treated women.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Australia; Epilepsy; Female; Humans; Parity; Pregnancy | 2013 |
Randomised controlled monotherapy trials: which comparators to use?
Topics: Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; Humans; Seizures; Valproic Acid | 2012 |
Rufinamide in children with refractory epilepsy: pharmacokinetics, efficacy, and safety.
Topics: Adolescent; Analysis of Variance; Anticonvulsants; Child; Child, Preschool; Chromatography, High Pre | 2012 |
Polycystic ovary syndrome in patients with epilepsy: a study in 102 Chinese women.
Topics: Adolescent; Adult; Asian People; Biomarkers; Child; Epilepsy; Female; Follicle Stimulating Hormone; | 2012 |
Lamotrigine related myocarditis: case report.
Topics: Adolescent; Anticonvulsants; Electrocardiography; Epilepsy; Humans; Lamotrigine; Magnetic Resonance | 2012 |
Therapeutic drug monitoring of free fraction valproic acid in patients with hypoalbuminaemia.
Topics: Anticonvulsants; Epilepsy; Fatal Outcome; Humans; Hypoalbuminemia; Male; Middle Aged; Valproic Acid | 2012 |
Arginase deficiency with new phenotype and a novel mutation: contemporary summary.
Topics: Anticonvulsants; Arginase; Base Sequence; Carcinoma, Hepatocellular; Cerebral Palsy; Codon, Nonsense | 2012 |
[Efficacy of the specific prolonged form of valproic acid (in the form of granules) in children with different forms of epilepsy].
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Delayed-Action Preparations; Epilepsy; Humans; | 2012 |
The role of ethanol on the anticonvulsant effect of valproic acid and cortical microvascular changes after epileptogenesis in mice.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Cerebrovascular Circulation; Drug Synergism; Drug Therapy | 2013 |
Asymmetric dimethylarginine may contribute to vascular risk factors in patients receiving antiepileptic drug treatment.
Topics: Anticonvulsants; Atherosclerosis; Carbamazepine; Carotid Artery, Common; Epilepsy; Female; Humans; M | 2012 |
Comparative stroke risk of antiepileptic drugs in patients with epilepsy.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Male | 2013 |
Epileptiform activity and cognitive deficits in SNAP-25(+/-) mice are normalized by antiepileptic drugs.
Topics: Animals; Anticonvulsants; Association Learning; Brain; Carbamazepine; Cognition Disorders; Epilepsy; | 2014 |
Evaluation of the possible epileptogenic activity of ciprofloxacin: the role of Nigella sativa on amino acids neurotransmitters.
Topics: Amino Acids; Animals; Anti-Bacterial Agents; Anticonvulsants; Antioxidants; Brain Chemistry; Chromat | 2013 |
[Pharmacological interaction between meropenem and valproic acid: a report of two cases].
Topics: Anticonvulsants; beta-Lactamase Inhibitors; Child, Preschool; Drug Interactions; Epilepsy; Fatal Out | 2012 |
Effects of UGT1A6, UGT2B7, and CYP2C9 genotypes on plasma concentrations of valproic acid in Chinese children with epilepsy.
Topics: Aryl Hydrocarbon Hydroxylases; Asian People; Child; Cytochrome P-450 CYP2C9; Epilepsy; Female; Genot | 2012 |
[Valproic acid pharmacogenetics in an individual approach to treatment of women of childbearing age with epilepsy].
Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Epilepsy; Female; Fertility | 2011 |
[Stigmata of dysembryogenesis and physical development in children born to mothers with epilepsy].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child Development; Child, Preschool; Developmental Dis | 2011 |
Carbamazepine, but not valproate, displays pharmacoresistance in lamotrigine-resistant amygdala kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Carbamazepine; Drug Resistance; Epilepsy; Kindling, Neurologic; | 2013 |
Zinc/Aluminum layered double hydroxide-titanium dioxide composite nanosheet film as novel solid phase microextraction fiber for the gas chromatographic determination of valproic acid.
Topics: Aluminum Hydroxide; Anticonvulsants; Chromatography, Gas; Epilepsy; Humans; Hydrogen-Ion Concentrati | 2013 |
How did phenobarbital's chemical structure affect the development of subsequent antiepileptic drugs (AEDs)?
Topics: Anticonvulsants; Carbamazepine; Drug Discovery; Epilepsy; Ethosuximide; History, 20th Century; Human | 2012 |
Valproate-associated reproductive hormone abnormalities: do bipolar men have the same risk as epileptic men?
Topics: Adolescent; Adult; Animals; Anticonvulsants; Bipolar Disorder; Disease Models, Animal; Endocrine Sys | 2012 |
A reversible cause of coma in epilepsy.
Topics: Adolescent; Anticonvulsants; Coma; Epilepsy; Female; Humans; Hyperammonemia; Valproic Acid | 2012 |
Valproate (VPA)-associated hyperammonemic encephalopathy independent of elevated serum VPA levels: 21 cases in China from May 2000 to May 2012.
Topics: Adolescent; Adult; Aged; Child, Preschool; China; Epilepsy; Female; Humans; Hyperammonemia; Male; Me | 2013 |
Effect of pregabalin add-on treatment on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy: a pilot study.
Topics: Adult; Aged; Anticonvulsants; Anxiety; Benzodiazepines; Brain Neoplasms; Carbamazepine; Clobazam; Dr | 2012 |
Assessment of atherosclerosis risk due to the homocysteine-asymmetric dimethylarginine-nitric oxide cascade in children taking antiepileptic drugs.
Topics: Adolescent; Anticonvulsants; Arginine; Atherosclerosis; Biomarkers; Carbamazepine; Child; Epilepsy; | 2013 |
Seizure control with antiepileptic drug therapy in 517 consecutive adult outpatients at the Kork Epilepsy Centre.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ambulatory Care; Anticonvulsants; Carbamazepine; Cross-S | 2012 |
Importance of accurate measurement of carotid intima-media thickness for evaluating epileptic children treated with valproate.
Topics: Adiponectin; Anticonvulsants; Carotid Intima-Media Thickness; Epilepsy; Female; Ghrelin; Humans; Lep | 2013 |
Reply from the authors of the article entitled "Importance of accurate measurement of carotid intima media thickness for evaluating epileptic children treated with valproate".
Topics: Adiponectin; Anticonvulsants; Carotid Intima-Media Thickness; Epilepsy; Female; Ghrelin; Humans; Lep | 2013 |
[Valproic acid-induced idiosyncratic liver injury in 4 cases].
Topics: Anticonvulsants; Biomarkers; Carnitine; Chemical and Drug Induced Liver Injury; Child; Child, Presch | 2012 |
Spatiotemporal dynamics of high-K+-induced epileptiform discharges in hippocampal slice and the effects of valproate.
Topics: Animals; Anticonvulsants; Brain Mapping; CA3 Region, Hippocampal; Disease Models, Animal; Epilepsy; | 2013 |
Polycystic ovaries, obesity and insulin resistance in women with epilepsy. A comparative study of carbamazepine and valproic acid in 105 women.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Insulin Resistance; Obesity; Polycy | 2002 |
Valproate-associated dysmyelopoiesis in elderly patients.
Topics: Anticonvulsants; Epilepsy; Female; Humans; Male; Middle Aged; Myelodysplastic Syndromes; Valproic Ac | 2002 |
Valproate embryopathy in three sets of siblings: further proof of hereditary susceptibility.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child; Child, Preschool; Developmental Disabil | 2002 |
Valproate-induced encephalopathy: assessment with MR imaging and 1H MR spectroscopy.
Topics: Adult; Anticonvulsants; Aspartic Acid; Brain; Brain Diseases, Metabolic; Choline; Creatine; Epilepsy | 2002 |
Effects of antiepileptic drugs on induced epileptiform activity in a rat model of dysplasia.
Topics: 4-Aminopyridine; Action Potentials; Animals; Animals, Newborn; Anticonvulsants; Carbamazepine; Disea | 2002 |
Studies on the pharmacokinetics of total and free valproate in mono- and bitherapy with carbamazepine in epileptic children and adolescents.
Topics: Adolescent; Carbamazepine; Child; Child, Preschool; Circadian Rhythm; Drug Therapy, Combination; Epi | 2002 |
[Clinical features and treatment of refractory epilepsy in children].
Topics: Adolescent; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam | 2001 |
Letter to the editor. Discordant twins for neural tube defect on treatment with sodium valproate.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Neural Tube Defects; Pregnancy; Prenatal Exposure | 2002 |
Does lamotrigine influence valproate concentrations?
Topics: Adolescent; Adult; Analysis of Variance; Child; Child, Preschool; Drug Interactions; Epilepsy; Femal | 2002 |
Fanconi syndrome caused by sodium valproate: report of three severely disabled children.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Disabled Children; Epilepsy; Fanconi Syndrome; | 2002 |
Anticonvulsant actions of gap junctional blockers in an in vitro seizure model.
Topics: 1-Octanol; Action Potentials; Ammonium Chloride; Animals; Anticonvulsants; Carbenoxolone; Connexins; | 2002 |
Therapy of Sneddon syndrome.
Topics: Adult; Antibodies, Antiphospholipid; Anticonvulsants; Aspirin; Azathioprine; Clopidogrel; Drug Thera | 2002 |
[Convulex and its place in epilepsy treatment with original valproates].
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Cost-Benefit Analysis; Epilepsy; Female; Humans; Ma | 2002 |
[Use of convulex in patients with epilepsy with and without affective disorders].
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Gen | 2002 |
Serum lipids, vitamin B12 and folic acid levels in children receiving long-term valproate therapy.
Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Folic Acid; Humans; Infant; Lipids; Male | 2002 |
Aggregate data meta-analysis with time-to-event outcomes.
Topics: Anticonvulsants; Carbamazepine; Cerebral Palsy; Cohort Studies; Epilepsy; Female; Humans; Life Table | 2002 |
Predictors of ovulatory failure in women with epilepsy.
Topics: Adolescent; Adult; Analysis of Variance; Anovulation; Anticonvulsants; Chi-Square Distribution; Epil | 2002 |
Outcome of pregnancy in women attending an outpatient epilepsy clinic: adverse features associated with higher doses of sodium valproate.
Topics: Abnormalities, Drug-Induced; Adolescent; Anticonvulsants; Child; Child, Preschool; Dose-Response Rel | 2002 |
Anticonvulsant valproate reduces seizure-susceptibility in mutant Drosophila.
Topics: Action Potentials; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Dru | 2002 |
Population pharmacokinetics of intravenous valproic acid in Korean patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Asian People; Bayes Theorem; Body Mass | 2002 |
Amino acid conjugates: metabolites of 2-propylpentanoic acid (valproic acid) in epileptic patients.
Topics: Adolescent; Amino Acids; Child; Epilepsy; Esters; Gas Chromatography-Mass Spectrometry; Humans; Valp | 2003 |
Valproic acid and lamotrigine treatment during pregnancy. The risk of chromosomal abnormality.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anticonvulsants; Chromosome Aberrations | 2003 |
Landau-Kleffner syndrome beginning with stuttering: case report.
Topics: Adrenocorticotropic Hormone; Aphasia; Child, Preschool; Diagnosis, Differential; Electroencephalogra | 2002 |
Valproate-associated reproductive and metabolic abnormalities: are epileptic women at greater risk than bipolar women?
Topics: Adult; Antimanic Agents; Bipolar Disorder; Cross-Sectional Studies; Endocrine System; Epilepsy; Fema | 2003 |
Oral/intravenous maintenance dosing of valproate following intravenous loading: a simulation.
Topics: Administration, Oral; Adult; Aging; Algorithms; Anticonvulsants; Child; Computer Simulation; Delayed | 2003 |
Effects of valproate and carbamazepine on serum levels of homocysteine, vitamin B12, and folic acid.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Folic Acid; H | 2003 |
Does long-term use of valproate cause weight gain in prepubertal epileptic children?
Topics: Anticonvulsants; Body Mass Index; Child; Epilepsy; Female; Humans; Leptin; Male; Time; Valproic Acid | 2002 |
Major malformations in offspring of women with epilepsy.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Comorbidity; Educational Status; | 2003 |
Comparison of lamotrigine and valproate with respect to quality of life.
Topics: Anticonvulsants; Epilepsy; Humans; Lamotrigine; Quality of Life; Triazines; Valproic Acid | 2003 |
Effects of age and polytherapy, risk factors of valproic acid (VPA) hepatotoxicity, on the excretion of thiol conjugates of (E)-2,4-diene VPA in people with epilepsy taking VPA.
Topics: Acetylcysteine; Adolescent; Adult; Age Factors; Anticonvulsants; Chemical and Drug Induced Liver Inj | 2003 |
No effect of long-term valproate therapy on thyroid and parathyroid functions in children.
Topics: Adolescent; Alkaline Phosphatase; Calcium; Child; Child, Preschool; Epilepsy; Humans; Infant; Osteoc | 2002 |
Immunoglobulins in children with epilepsy: the Dutch Study of Epilepsy in Childhood.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Case-Control Studies; Chi-Square Distribution; Child; Ch | 2003 |
Carnitine level in Chinese epileptic patients taking sodium valproate.
Topics: Adolescent; Anticonvulsants; Asian People; Carnitine; Child; Epilepsy; Female; Humans; Male; Metabol | 2003 |
Favorable outcome of epileptic blindness in children.
Topics: Acute Disease; Adolescent; Anticonvulsants; Blindness, Cortical; Carbamazepine; Child; Electroenceph | 2003 |
Evaluation of therapeutic drug monitoring of antiepileptic drugs.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dose-Response Rela | 2003 |
Volume-selective 1H MR spectroscopy for in vivo detection of valproate in patients with epilepsy.
Topics: Adult; Anticonvulsants; Brain Chemistry; Epilepsy; Female; Humans; Magnetic Resonance Spectroscopy; | 2003 |
Antiepileptic drug hypersensitivity syndrome in a patient treated with valproate.
Topics: Adult; Anticonvulsants; Drug Eruptions; Drug Hypersensitivity; Epilepsy; Humans; Hyperplasia; Lymph | 2003 |
Hypouricemia in severely disabled children: influence of valproic acid and bed-ridden state.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Disabled Children; Epilepsy; Female; Hu | 2003 |
Uptake of GABA and activity of GABA-transaminase in platelets from epileptic patients.
Topics: 4-Aminobutyrate Transaminase; Adult; Anticonvulsants; Blood Platelets; Case-Control Studies; Dose-Re | 2003 |
Valproic acid-associated weight gain in older children and teens with epilepsy.
Topics: Adolescent; Anticonvulsants; Body Mass Index; Child; Epilepsy; Female; Follow-Up Studies; Humans; Ma | 2003 |
[Effects of valproate on sexual development].
Topics: Age Determination by Skeleton; Anthropometry; Anticonvulsants; Child; Epilepsy; Female; Gonadal Ster | 2003 |
Effects of valproic acid, carbamazepine, and phenobarbitone on the fatty acid composition of erythrocyte membranes in children.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Erythrocyte Membrane; | 2003 |
Safety and efficacy of intravenous valproate in pediatric status epilepticus and acute repetitive seizures.
Topics: Acute Disease; Adolescent; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Dru | 2003 |
Do epileptic children treated with valproate have a risk of excessive weight gain?
Topics: Age Factors; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Obesi | 2003 |
Higher androgens and weight gain with valproate compared with lamotrigine for epilepsy.
Topics: Adult; Analysis of Variance; Androgens; Confidence Intervals; Cross-Sectional Studies; Epilepsy; Fem | 2003 |
HPLC determination of valproic acid in human serum.
Topics: Anticonvulsants; Chromatography, High Pressure Liquid; Epilepsy; Humans; Reference Standards; Reprod | 2003 |
Direct observation of 3-keto-valproate in urine by 2D-NMR spectroscopy.
Topics: Adolescent; Anticonvulsants; Consanguinity; Epilepsy; Humans; Indicators and Reagents; Ketones; Magn | 2003 |
Lamotrigine and valproate: efficacy of co-administration in a pediatric population.
Topics: Adolescent; Ambulatory Care; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Female; F | 2003 |
Reversible altered consciousness with brain atrophy caused by valproic acid.
Topics: Atrophy; Brain; Child, Preschool; Consciousness Disorders; Electroencephalography; Epilepsy; Female; | 2003 |
Successful pregnancy in a patient with hyperoxaluria and combined liver and renal transplant.
Topics: Adult; Epilepsy; Female; Humans; Hyperoxaluria; Infant, Newborn; Kidney Transplantation; Liver Trans | 2003 |
Absence seizures in patients with localization-related epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Electroencephalogra | 2003 |
A study of anticonvulsant medication on ovarian function in a group of women with epilepsy who have only ever taken one anticonvulsant compared with a group of women without epilepsy.
Topics: Anticonvulsants; Carbamazepine; Case-Control Studies; Epilepsy; Female; Follicle Stimulating Hormone | 2003 |
EDTA-dependent pseudothrombocytopenia induced by valproic acid.
Topics: Anticonvulsants; Diagnostic Errors; Edetic Acid; Epilepsy; False Positive Reactions; Female; Heparin | 2003 |
Alterations in semen parameters in men with epilepsy treated with valproate or carbamazepine monotherapy.
Topics: Adult; Analysis of Variance; Carbamazepine; Epilepsy; Humans; Male; Semen; Sperm Count; Spermatozoa; | 2003 |
The Australian registry of anti-epileptic drugs in pregnancy: experience after 30 months.
Topics: Abortion, Induced; Anticonvulsants; Australia; Carbamazepine; Cohort Studies; Congenital Abnormaliti | 2003 |
[COMMUNICATION CONCERNING 1ST CLINICAL TESTS OF THE ANTICONVULSIVE ACTIVITY OF N-DIPROPYLACETIC ACID (SODIUM SALT)].
Topics: Adolescent; Anticonvulsants; Child; Electroencephalography; Epilepsy; Fatty Acids; Humans; Sodium; V | 1964 |
[Fetal valproate syndrome].
Topics: Anticonvulsants; Epilepsy; Female; Humans; Maternal-Fetal Exchange; Pregnancy; Pregnancy Complicatio | 2003 |
[Influence of valproic acid (depakine I.V.) on human placenta metabolism--experimental model].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Blood Glucose; Embryo, Mammalian; Embryonic and Fetal | 2003 |
Multiple congenital malformations including generalized hypertrichosis with gum hypertrophy in a child exposed to valproic acid in utero.
Topics: Abnormalities, Multiple; Anticonvulsants; Dermatoglyphics; Epilepsy; Fatal Outcome; Female; Gingiva; | 2003 |
[Fetal valproate syndrome].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Maternal-Fetal Exchange; Pre | 2003 |
Dynamic release of amino acid transmitters induced by valproate in PTZ-kindled epileptic rat hippocampus.
Topics: Amino Acid Transport Systems; Amino Acids; Animals; Anticonvulsants; Epilepsy; Hippocampus; Kindling | 2004 |
[A case of infantile epileptic apnea with congenital brain anomaly].
Topics: Apnea; Brain; Electroencephalography; Epilepsy; Female; Humans; Infant; Intellectual Disability; Val | 2003 |
Serum insulin and leptin levels and valproate-associated obesity.
Topics: Adult; Anticonvulsants; Body Composition; Body Mass Index; Child; Epilepsy; Feedback; Female; Humans | 2003 |
Pharmacokinetic modelling of valproic acid from routine clinical data in Egyptian epileptic patients.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clinical Trials as Topic | 2004 |
Compliance and satisfaction with switching from an immediate-release to sustained-release formulation of valproate in people with epilepsy.
Topics: Adaptation, Psychological; Adolescent; Adult; Age of Onset; Aged; Anticonvulsants; Delayed-Action Pr | 2003 |
The relationship between treatment with valproate, lamotrigine, and topiramate and the prognosis of the idiopathic generalised epilepsies.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Databases, Factual; Electroencephalogra | 2004 |
Normal intelligence in children with prenatal exposure to carbamazepine.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsy; | 2004 |
Serum nitrite and nitrate levels in epileptic children using valproic acid or carbamazepine.
Topics: Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Humans; Male; Nitrates; Nitric Oxide; Nitri | 2004 |
Hypouricemia in severely disabled children II: influence of elemental enteral nutrition on the serum uric acid levels.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Disabled Children; Enteral Nutrition; E | 2004 |
Epilepsy syndrome, focus location, and treatment choice affect testicular function in men with epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Epileps | 2004 |
Effect of epilepsy and antiepileptic drugs on male reproductive health.
Topics: Adult; Androstenedione; Anticonvulsants; Carbamazepine; Dehydroepiandrosterone Sulfate; Epilepsies, | 2004 |
[Childhood-onset epileptic blindness--clinical correlates and outcomes].
Topics: Age of Onset; Anticonvulsants; Blindness; Carbamazepine; Child; Epilepsy; Follow-Up Studies; Humans; | 2004 |
Long-term reproductive endocrine health in young women with epilepsy during puberty.
Topics: Adolescent; Anticonvulsants; Child; Cohort Studies; Comorbidity; Epilepsy; Female; Finland; Follow-U | 2004 |
Interaction between anticonvulsants and human placental carnitine transporter.
Topics: Acetates; Amines; Aminoisobutyric Acids; Anticonvulsants; Carnitine; Carrier Proteins; Culture Techn | 2004 |
Cost of epilepsy in patients attending a secondary-level hospital in India.
Topics: Anticonvulsants; Carbamazepine; Efficiency, Organizational; Epilepsy; Hospital Costs; Hospitalizatio | 2004 |
[A case of polymyalgia rheumatica with improved steroid-responsibility after discontinuing carbamazepine].
Topics: Aged; Anticonvulsants; Carbamazepine; Drug Resistance; Epilepsy; Female; Humans; Methotrexate; Polym | 2004 |
The effect of long-term antiepileptic treatment on serum cholesterol (TC, HDL, LDL) and triglyceride levels in adult epileptic patients on monotherapy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Cholesterol; Cholesterol, HDL; Cholesterol, | 2004 |
Major malformations in infants exposed to antiepileptic drugs in utero, with emphasis on carbamazepine and valproic acid: a nation-wide, population-based register study.
Topics: Abnormalities, Multiple; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fetal Diseases; Hu | 2004 |
Nonparametric population modeling of valproate pharmacokinetics in epileptic patients using routine serum monitoring data: implications for dosage.
Topics: Adolescent; Adult; Anticonvulsants; Bayes Theorem; Child; Child, Preschool; Drug Monitoring; Epileps | 2004 |
Drug induced encephalopathy in six epileptic patients: topiramate? valproate? or both?
Topics: Adolescent; Adult; Ammonia; Anticonvulsants; Drug Interactions; Drug Therapy, Combination; Electroen | 2004 |
Valproate therapy and nonalcoholic fatty liver disease.
Topics: Adolescent; Adult; Carbamazepine; Chi-Square Distribution; Epilepsy; Fatty Liver; Female; Humans; Ma | 2004 |
Effect of combination of dizocilpine with general antiepileptic drugs on amygdala kindling models in rats.
Topics: Amygdala; Animals; Anticonvulsants; Dizocilpine Maleate; Electric Stimulation; Epilepsy; Female; Kin | 2004 |
Divalproex-ER pharmacokinetics in older children and adolescents.
Topics: Adolescent; Adult; Area Under Curve; Child; Confidence Intervals; Delayed-Action Preparations; Epile | 2004 |
[Insulin resistance in epileptic patients during treatment of valproic acid].
Topics: Adult; Body Mass Index; Epilepsy; Female; Humans; Insulin Resistance; Male; Valproic Acid; Weight Ga | 2004 |
Serum androgen levels and testicular structure during pubertal maturation in male subjects with epilepsy.
Topics: Adolescent; Adult; Androgens; Androstenedione; Anticonvulsants; Carbamazepine; Child; Epilepsy; Huma | 2004 |
Health-related quality of life of people with epilepsy compared with a general reference population: a Tunisian study.
Topics: Adolescent; Adult; Ambulatory Care; Anticonvulsants; Case-Control Studies; Cross-Cultural Comparison | 2004 |
Fanconi syndrome caused by antiepileptic therapy with valproic Acid.
Topics: Anticonvulsants; Child; Epilepsy; Fanconi Syndrome; Hand; Humans; Male; Radiography; Valproic Acid | 2004 |
The difficulties of diagnosing VPA-induced pancreatitis in children with severe motor and intellectual disabilities.
Topics: Acute Disease; Anticonvulsants; Child, Preschool; Epilepsy; Female; Humans; Intellectual Disability; | 2004 |
Casebook: epileptic seizures and turns.
Topics: Adolescent; Adult; Anticonvulsants; Contraindications; Diagnosis, Differential; Epilepsy; Female; Hu | 2004 |
Color vision in epileptic adolescents treated with valproate and carbamazepine.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Color Perception; Epilepsy; Female; Humans; Male; | 2004 |
Activation of serum aminotransferases by pyridoxal-5' -phosphate in epileptic patients treated with anticonvulsant drugs.
Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Carbamazepine; Drug Therapy, Combination; | 2004 |
Physical growth and endocrinal disorders during pubertal maturation in girls with epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Dehydroepiandrosterone; Epilepsy; Female; Growth; | 2004 |
Effects of piracetam alone and in combination with antiepileptic drugs in rodent seizure models.
Topics: Action Potentials; Animals; Anticonvulsants; Brain; Cobalt; Disease Models, Animal; Drug Combination | 2004 |
Bioavailability of divalproex extended-release formulation relative to the divalproex delayed-release formulation.
Topics: Anticonvulsants; Area Under Curve; Biological Availability; Chemistry, Pharmaceutical; Delayed-Actio | 2004 |
Cognitive profile of topiramate as compared with lamotrigine in epilepsy patients on antiepileptic drug polytherapy: relationships to blood serum levels and comedication.
Topics: Adult; Anticonvulsants; Cognition; Drug Therapy, Combination; Epilepsy; Female; Fructose; Humans; La | 2004 |
Clinical comparison of extended-release divalproex versus delayed-release divalproex: pooled data analyses from nine trials.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Child; Child, Preschool; Clinical Trial | 2004 |
Navigating toward fetal and maternal health: the challenge of treating epilepsy in pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Child; Cohort Studies; Confoundi | 2004 |
Effect of carbamazepine and valproate on bone mineral density.
Topics: Adolescent; Anticonvulsants; Bone Density; Carbamazepine; Case-Control Studies; Child; Cross-Section | 2004 |
The outcome of initiation of antiepileptic drug monotherapy in primary care: a UK database survey.
Topics: Aged; Anticonvulsants; Carbamazepine; Child, Preschool; Clinical Competence; Epilepsy; Family Practi | 2004 |
Assessment of the epilepsy treatment gap in two cities of south-east of Brazil.
Topics: Adult; Anticonvulsants; Brazil; Carbamazepine; Epilepsy; Health Services Accessibility; Health Servi | 2004 |
Longer term outcome of children born to mothers with epilepsy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Fema | 2004 |
The longer term outcome of children born to mothers with epilepsy.
Topics: Abnormalities, Drug-Induced; Adolescent; Anticonvulsants; Child; Child, Preschool; Cognition Disorde | 2004 |
Fracture risk associated with use of antiepileptic drugs.
Topics: Adult; Anticonvulsants; Bone Density; Carbamazepine; Case-Control Studies; Denmark; Epilepsy; Female | 2004 |
Australian pregnancy registry of women taking antiepileptic drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Australia; Drug Therapy, Combination; Epilepsy; Female | 2004 |
Critical relationship between sodium valproate dose and human teratogenicity: results of the Australian register of anti-epileptic drugs in pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Australia; Dose-Response Relationship, Drug; Epilepsy; | 2004 |
Subregional changes in discharge rate, pattern, and drug sensitivity of putative GABAergic nigral neurons in the kindling model of epilepsy.
Topics: Action Potentials; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Female; gamma-Aminobu | 2004 |
Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats.
Topics: Adrenergic Agents; Aminoglutethimide; Amygdala; Animals; Anticonvulsants; Clonazepam; Disease Models | 2005 |
Valproic acid-induced pancreatitis in childhood epilepsy: case series and review.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diagnosis, Differential; Dose-Response Relatio | 2004 |
Valproate-induced hyperammonemic encephalopathy: imaging findings on diffusion-weighted MRI.
Topics: Brain; Brain Mapping; Diffusion Magnetic Resonance Imaging; Epilepsy; Humans; Male; Middle Aged; Mul | 2004 |
[Efficacy and safety of antiepileptic therapy in children (a comparative analysis of valproates and barbiturates)].
Topics: Adolescent; Age Factors; Anticonvulsants; Barbiturates; Child; Child, Preschool; Electroencephalogra | 2004 |
[Valproate-induced hyperammonemic encephalopathy in a patient with Sjögren's syndrome].
Topics: Anticonvulsants; Epilepsy; Female; Humans; Hyperammonemia; Magnetic Resonance Imaging; Middle Aged; | 2004 |
Population pharmacokinetic model of valproate and prediction of valproate serum concentrations in children with epilepsy.
Topics: Adolescent; Bayes Theorem; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Models, | 2004 |
Influence of coadministered antiepileptic drugs on serum phenobarbital concentrations in epileptic patients: quantitative analysis based on a suitable transforming factor.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Child; Chil | 2004 |
[Influence of psychotropic drugs on thrombocytes aggregation in patients with epilepsy].
Topics: Adolescent; Adult; Barbiturates; Carbamazepine; Epilepsy; Humans; In Vitro Techniques; Lamotrigine; | 2004 |
Initiation of treatment and selection of antiepileptic drugs in childhood epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; | 2004 |
Effect of long-term therapy with sodium valproate on nail and serum trace element status in epileptic children.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Copper; Epilepsy; Female; Humans; Infant; Male | 2004 |
Valproic acid intoxication: sense and non-sense of haemodialysis.
Topics: Adult; Drug Overdose; Epilepsy; Ethanol; Hemodiafiltration; Hemoperfusion; Humans; Male; Mental Diso | 2004 |
Efficacy and tolerability of the new antiepileptic drugs I: treatment of new onset epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epileps
Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; Fructose; Humans; Seizures; Topiramate; Valproi | 2005 |
Bone mass and turnover in women with epilepsy on antiepileptic drug monotherapy.
Topics: Adolescent; Adult; Anticonvulsants; Bone and Bones; Bone Remodeling; Carbamazepine; Epilepsy; Female | 2005 |
Antiepileptic drugs alter reproductive endocrine hormones in men with epilepsy.
Topics: Adult; Age Factors; Androstenedione; Anticonvulsants; C-Peptide; Carbamazepine; Carnitine; Dihydrote | 2005 |
Investigating heterogeneity in an individual patient data meta-analysis of time to event outcomes.
Topics: Anticonvulsants; Carbamazepine; Computer Simulation; Epilepsy; Genetic Heterogeneity; Humans; Meta-A | 2005 |
Acute seizures due to a probable interaction between valproic acid and meropenem.
Topics: Acute Disease; Adult; Anti-Bacterial Agents; Anticonvulsants; Drug Interactions; Epilepsy; Female; H | 2005 |
Gingival enlargement in children treated with antiepileptics.
Topics: Anticonvulsants; Carbamazepine; Case-Control Studies; Child; Cross-Sectional Studies; Dental Plaque | 2004 |
[Sjögren's syndrome with autonomic failure and epilepsy].
Topics: Aged; Anti-Inflammatory Agents; Anticonvulsants; Autonomic Nervous System Diseases; Electromyography | 2005 |
Complex cardiac defect with hypoplastic right ventricle in a fetus with valproate exposure.
Topics: Abortion, Induced; Adult; Anticonvulsants; Diagnosis, Differential; Epilepsy; Female; Heart Defects, | 2005 |
Autoimmune haemolytic anaemia and renal Fanconi syndrome caused by valproate therapy.
Topics: Anemia, Hemolytic, Autoimmune; Anticonvulsants; Child, Preschool; Epilepsy; Fanconi Syndrome; Female | 2005 |
Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice.
Topics: Aggression; Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Blotting, Western; Cell Adh | 2005 |
Valproic acid induces differentiation of a supratentorial primitive neuroectodermal tumor.
Topics: Cell Differentiation; Cell Proliferation; Child; Epilepsy; Family Health; Humans; Male; Neuroectoder | 2004 |
What can we say to women of reproductive age with epilepsy?
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Dose-Response Relationship, Drug; E | 2005 |
Neuropsychological effects of exposure to anticonvulsant medication in utero.
Topics: Adolescent; Anticonvulsants; Brain; Child; Cognition Disorders; Cohort Studies; Epilepsy; Female; Hu | 2005 |
Increased rate of major malformations in offspring exposed to valproate during pregnancy.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Inte | 2005 |
Valproate-induced eosinophilia in children with epilepsy: role of interleukin-5.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Case-Control Studies; Child; Child, Preschool; Eosinophi | 2005 |
Topiramate-valproate-induced hyperammonemic encephalopathy syndrome: case report.
Topics: Adolescent; Anticonvulsants; Brain Diseases; Chromosome Inversion; Chromosomes, Human, Pair 15; Drug | 2005 |
Acute leukemia associated with valproic acid treatment: a novel mechanism for leukemogenesis?
Topics: Acute Disease; Adult; Anticonvulsants; Chromosome Aberrations; Chromosomes, Human, Pair 7; Chromosom | 2005 |
Sodium valproate -- induced skeletal myopathy.
Topics: Anticonvulsants; Carbamazepine; Carnitine; Child, Preschool; Epilepsy; Humans; Male; Muscular Diseas | 2005 |
Valproate-induced proximal renal tubular dysfunction: clinically relevant in the severely disabled epileptic population.
Topics: Adolescent; Adult; Anticonvulsants; Disabled Persons; Epilepsy; Fanconi Syndrome; Female; Humans; Ma | 2005 |
Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptics.
Topics: Anticonvulsants; Carbamazepine; Causality; Epilepsy; Germany; Humans; Incidence; Inpatients; Lamotri | 2005 |
Pharmacokinetic interaction on valproic acid and recurrence of epileptic seizures during chemotherapy in an epileptic patient.
Topics: Adult; Anticonvulsants; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cisplatin; Drug I | 2005 |
Telogen effluvium caused by magnesium valproate and lamotrigine.
Topics: Acute Disease; Adolescent; Adult; Alopecia; Anticonvulsants; Epilepsy; Female; Humans; Lamotrigine; | 2005 |
Lack of pharmacokinetic interactions between steady-state zonisamide and valproic acid in patients with epilepsy.
Topics: Adult; Anticonvulsants; Drug Interactions; Epilepsy; Female; Humans; Isoxazoles; Male; Middle Aged; | 2005 |
[The use of valproates-generics in the treatment of epileptic patients].
Topics: Adult; Electroencephalography; Epilepsy; Female; Humans; Male; Quality of Life; Valproic Acid | 2005 |
Motor impairment on awakening in a patient with an EEG pattern of "unilateral, continuous spikes and waves during slow sleep".
Topics: Anticonvulsants; Arm; Benzodiazepines; Child; Clobazam; Electroencephalography; Epilepsy; Ethosuximi | 2005 |
Blood homocysteine, folate and vitamin B-12 concentrations in patients with epilepsy receiving lamotrigine or sodium valproate for initial monotherapy.
Topics: Adult; Epilepsy; Female; Folic Acid; Homocysteine; Humans; Lamotrigine; Male; Middle Aged; Triazines | 2005 |
Serum valproate levels with oral contraceptive use.
Topics: Adult; Anticonvulsants; Comorbidity; Contraceptives, Oral, Combined; Drug Combinations; Drug Interac | 2005 |
Antiepileptic drug use of women with epilepsy and congenital malformations in offspring.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Cardiovascular Abnormalities; Cleft Palate; Coh | 2005 |
Seizure worsening caused by decreased serum valproate during meropenem therapy.
Topics: Anti-Bacterial Agents; Anticonvulsants; Child; Drug Interactions; Epilepsy; Female; Humans; Meropene | 2005 |
Lethal obesity associated with sodium valproate in a brain-injured patient.
Topics: Adult; Anticonvulsants; Brain Injuries; Epilepsy; Fatal Outcome; Heart Failure; Humans; Male; Obesit | 2005 |
Valproate-induced hyperammonemic encephalopathy with normal liver function.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Epilepsy; Female; Humans; Liver; Liver Function Tests; Mal | 2005 |
A comparative study of the effect of carbamazepine and valproic acid on the pharmacokinetics and metabolic profile of topiramate at steady state in patients with epilepsy.
Topics: Adult; Anticonvulsants; Biological Availability; Carbamazepine; Dose-Response Relationship, Drug; Dr | 2005 |
Fit for a fracture.
Topics: Anticonvulsants; Epilepsy; Ergocalciferols; Female; Femoral Neck Fractures; Follow-Up Studies; Fract | 2005 |
Maternal valproate dosage and foetal malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Logistic Models; Pregnancy; | 2005 |
[Hyperammonemia secondary to the use of valproic acid: case report].
Topics: Anticonvulsants; Child; Epilepsy; Humans; Hyperammonemia; Male; Valproic Acid | 2005 |
Pharmacokinetic interactions of carbamazepine with some antiepileptic drugs during epilepsy treatment in children and adolescents.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Drug Interactions; Epilepsy; Female; Fructose; Hu | 2005 |
Weight change in monozygotic twins treated with valproate.
Topics: Adolescent; Adult; Anticonvulsants; Child, Preschool; Diseases in Twins; Epilepsy; Female; Humans; M | 2005 |
Treatment with valproic acid for myelofibrosis with myeloid metaplasia.
Topics: Aged; Anticonvulsants; Blood Cell Count; Epilepsy; Female; Hemorrhage; Humans; Primary Myelofibrosis | 2005 |
[Determination of sodium valproate in serum by gas chromatography].
Topics: Anticonvulsants; Chromatography, High Pressure Liquid; Epilepsy; Humans; Valproic Acid | 2004 |
Valproate-induced bleeding: report of two cases and review of literature.
Topics: Adolescent; Anticonvulsants; Child; Epilepsy; Epilepsy, Absence; Factor XII Deficiency; Female; Hemo | 2005 |
Preclinical profiling and safety studies of ABT-769: a compound with potential for broad-spectrum antiepileptic activity.
Topics: Abnormalities, Drug-Induced; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Disease Models, A | 2005 |
Safety and tolerability of the ketogenic diet in pediatric epilepsy: effects of valproate combination therapy.
Topics: Acidosis; Anticonvulsants; Child; Child, Preschool; Combined Modality Therapy; Dietary Fats; Epileps | 2005 |
Lamotrigine associated with exacerbation or de novo myoclonus in idiopathic generalized epilepsies.
Topics: Adult; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Epilepsie | 2005 |
Dysmorphic features: an important clue to the diagnosis and severity of fetal anticonvulsant syndromes.
Topics: Abnormalities, Drug-Induced; Adolescent; Anthropometry; Anticonvulsants; Carbamazepine; Child; Child | 2006 |
Epilepsy and medication effects on the pattern visual evoked potential.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Evoked Potentials, Visual; Female; Follow-Up Studie | 2005 |
[Effect of carbamazepine and valproate on bone metabolism in children with epilepsy].
Topics: Amino Acids; Anticonvulsants; Bone and Bones; Bone Density; Calcium, Dietary; Carbamazepine; Child; | 2005 |
Improvement of oligoasthenozoospermia in epileptic patients on switching anti-epilepsy medication from sodium valproate to phenytoin.
Topics: Adult; Anticonvulsants; Epilepsy; Follow-Up Studies; Humans; Male; Oligospermia; Phenytoin; Sperm Co | 2005 |
[Anticonvulsive pharmacotherapy may aggravate epilepsy course].
Topics: Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Electroencephalography; Epilepsy; | 2005 |
Acute hyperammonemic coma with chronic valproic acid therapy.
Topics: Anticonvulsants; Coma; Electroencephalography; Epilepsy; Female; Humans; Hyperammonemia; Middle Aged | 2005 |
[The efficacy of topiramate (topamax) in the treatment of resistant epilepsy in children].
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Resistance; Drug Therapy, | 2005 |
The use of lamotrigine and other antiepileptic drugs in paediatric patients at a Malaysian hospital.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cost-Benefit Analysis; D | 2005 |
Leptin, ghrelin, and adiponectin in epileptic patients treated with valproic acid.
Topics: Adiponectin; Adipose Tissue; Adolescent; Adult; Anticonvulsants; Appetite Regulation; Body Weight; B | 2005 |
Valproate-induced insulin resistance in prepubertal girls with epilepsy.
Topics: Adolescent; Androstenedione; Anticonvulsants; Blood Glucose; Body Mass Index; Child; Cross-Sectional | 2005 |
Possible precipitation of myoclonic seizures with oxcarbazepine.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsy; Female; Humans; Infant | 2006 |
Management of epilepsy in adults. Diagnosis guidelines.
Topics: Adolescent; Adult; Algorithms; Anticonvulsants; Child; Diagnosis, Differential; Electroencephalograp | 2005 |
Frequency of epileptiform EEG abnormalities in a sequential screening of autistic patients with no known clinical epilepsy from 1996 to 2005.
Topics: Adolescent; Adult; Anticonvulsants; Autistic Disorder; Child; Child, Preschool; Electroencephalograp | 2006 |
Effects of common anti-epileptic drug monotherapy on serum levels of homocysteine, vitamin B12, folic acid and vitamin B6.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Epilepsy; Female; Folic Aci | 2006 |
Parkinsonism and/or cognitive impairment with valproic acid therapy: a report of ten cases.
Topics: Aged; Anticonvulsants; Cognition Disorders; Epilepsy; Female; Humans; Male; Middle Aged; Parkinsonia | 2006 |
Chrono impact versus enteric coated valproate in Thai epileptic patients.
Topics: Adult; Aged; Anticonvulsants; Delayed-Action Preparations; Epilepsy; Female; Humans; Male; Middle Ag | 2005 |
Screening for bipolar disorder in women with polycystic ovary syndrome: a pilot study.
Topics: Adolescent; Adult; Anticonvulsants; Bipolar Disorder; Epilepsy; Female; Humans; Mass Screening; Midd | 2006 |
Lack of association between the C3435T polymorphism in the human multidrug resistance (MDR1) gene and response to antiepileptic drug treatment.
Topics: Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug Interactions; Drug Th | 2006 |
Detecting vigabatrin toxicity by imaging of the retinal nerve fiber layer.
Topics: Adult; Anticonvulsants; Carbamazepine; Cross-Sectional Studies; Epilepsy; Female; Humans; Male; Nerv | 2006 |
[Ergenyl chronospheres in juvenile and senile epilepsies].
Topics: Adolescent; Age Factors; Aged; Child; Chronotherapy; Controlled Clinical Trials as Topic; Delayed-Ac | 2005 |
CACNA1A mutation in a EA-2 patient responsive to acetazolamide and valproic acid.
Topics: Acetazolamide; Adult; Amino Acid Sequence; Animals; Anticonvulsants; Calcium Channels; Diagnosis, Di | 2006 |
Insulin-related metabolic changes during treatment with valproate in patients with epilepsy.
Topics: Adult; Anticonvulsants; Body Mass Index; Epilepsy; Female; Humans; Hyperinsulinism; Insulin; Lipopro | 2006 |
Effect of intracerebroventricular continuous infusion of valproic acid versus single i.p. and i.c.v. injections in the amygdala kindling epilepsy model.
Topics: Amygdala; Animals; Anticonvulsants; Cerebral Ventricles; Disease Models, Animal; Dose-Response Relat | 2006 |
Retinal nerve fiber layer and macular thickness in adolescents with epilepsy treated with valproate and carbamazepine.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Color Vision Defects; Epilepsy; Female; Follow-Up | 2006 |
Predicted plasma valproic acid concentrations in patients missing and replacing a full daily dose of extended-release divalproex sodium.
Topics: Anticonvulsants; Delayed-Action Preparations; Epilepsy; Forecasting; Humans; Patient Compliance; Val | 2006 |
A case of fetal anticonvulsant syndrome with severe bilateral upper limb defect.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fetal Diseases | 2006 |
[Polycystic ovary syndrome and hepatocellular adenoma related to long-term use of sodium valproate in a young woman].
Topics: Adenoma, Liver Cell; Adult; Epilepsy; Female; Humans; Hyperandrogenism; Liver Neoplasms; Polycystic | 2006 |
Serum total amylase, pancreatic amylase and lipase activities in epileptic children treated with sodium valproate monotherapy.
Topics: Adolescent; Amylases; Anticonvulsants; Child; Child, Preschool; Clinical Enzyme Tests; Epilepsy; Fem | 2006 |
The influence of old age and enzyme inducing comedication on the pharmacokinetics of valproic acid at steady-state: A case-matched evaluation based on therapeutic drug monitoring data.
Topics: Adult; Aged; Aging; Anticonvulsants; Case-Control Studies; Dose-Response Relationship, Drug; Drug In | 2006 |
Antiepileptic drug use and birth rate in patients with epilepsy--a population-based cohort study in Finland.
Topics: Adolescent; Adult; Anticonvulsants; Birth Rate; Carbamazepine; Cohort Studies; Epilepsy; Female; Fin | 2006 |
[Investigation of efficacy of convulex-retard in epilepsy treatment].
Topics: Adolescent; Adult; Aged; Anticonvulsants; Delayed-Action Preparations; Dose-Response Relationship, D | 2006 |
Excitability of the human epileptic cortex after chronic valproate: a reappraisal.
Topics: Adolescent; Adult; Analysis of Variance; Anticonvulsants; Cerebral Cortex; Drug Administration Sched | 2006 |
Does it really matter when a blood sample for valproic acid concentration is taken following once-daily administration of divalproex-ER?
Topics: Anticonvulsants; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Administration | 2006 |
Valproic acid, an antiepileptic drug with histone deacetylase inhibitory activity, potentiates the cytotoxic effect of Apo2L/TRAIL on cultured thoracic cancer cells through mitochondria-dependent caspase activation.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Carcinoma, Non-Small-Cell Lung; Caspases; Cell Line, Tumor | 2006 |
Protein C, protein S and other pro- and anticoagulant activities among epileptic children using sodium valproate.
Topics: Adolescent; Anticoagulants; Anticonvulsants; Blood Cell Count; Case-Control Studies; Child; Child, P | 2006 |
Effect of delayed and/or missed enteric-coated divalproex doses on valproic acid concentrations: simulation and dose replacement recommendations for the clinician.
Topics: Adult; Anticonvulsants; Computer Simulation; Delayed-Action Preparations; Drug Administration Schedu | 2006 |
Epileptic seizures caused by low valproic acid levels from an interaction with meropenem.
Topics: Anticonvulsants; Drug Interactions; Epilepsy; Female; Humans; Meropenem; Middle Aged; Pneumonia; Thi | 2006 |
Valproate-associated coagulopathies are frequent and variable in children.
Topics: Age Factors; Anticonvulsants; Blood Coagulation Tests; Child; Coagulation Protein Disorders; Epileps | 2006 |
Early effect of sodium valproate and carbamazepine monotherapy on homocysteine metabolism in children with epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Folic Acid; H | 2006 |
Adverse effects of antiepileptic drugs on bone mineral density.
Topics: Adolescent; Anticonvulsants; Bone Density; Calcification, Physiologic; Carbamazepine; Case-Control S | 2006 |
Characterization of insulin secretion in Valproate-treated patients with epilepsy.
Topics: Adult; Anticonvulsants; Blood Glucose; C-Peptide; Epilepsy; Fasting; Female; Humans; Hyperinsulinism | 2006 |
Increased apparent oral clearance of valproic acid during intake of combined contraceptive steroids in women with epilepsy.
Topics: Administration, Oral; Adolescent; Adult; Anticonvulsants; Contraceptives, Oral, Combined; Contracept | 2006 |
Idiopathic hypereosinophilic syndrome complicated by central sinovenous thrombosis.
Topics: Anticoagulants; Anticonvulsants; Cerebral Hemorrhage; Child; DNA Mutational Analysis; Epilepsy; Huma | 2007 |
Capillary microscopy and hemorheology in children during antiepileptic monotherapy with carbamazepine and valproate.
Topics: Adolescent; Anticonvulsants; Blood Flow Velocity; Capillaries; Carbamazepine; Cerebellar Cortex; Chi | 2006 |
Movement disorders in patients taking anticonvulsants.
Topics: Adult; Aged; Anticonvulsants; Cross-Sectional Studies; Epilepsy; Female; Humans; Male; Middle Aged; | 2007 |
The effects of valproate exposure in utero on behavior and the need for educational support in school-aged children.
Topics: Anticonvulsants; Carbamazepine; Child; Cognition; Education, Special; Epilepsy; Female; Humans; Ment | 2006 |
Autonomic headache with autonomic seizures: a case report.
Topics: Anticonvulsants; Autonomic Nervous System; Diagnosis, Differential; Electroencephalography; Epilepsy | 2006 |
Oral rapid loading of valproic acid--an alternative to the usual saturation scheme?
Topics: Administration, Oral; Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; T | 2006 |
Oxidative stress in children receiving valproic acid.
Topics: Adolescent; Age Factors; Anticonvulsants; Benzodiazepines; Biomarkers; Canada; Carbamazepine; Case-C | 2006 |
Reproductive endocrine function in women with epilepsy: the role of epilepsy type and medication.
Topics: Adolescent; Adult; Analysis of Variance; Anticonvulsants; Epilepsy; Female; Humans; Hyperandrogenism | 2007 |
Brain pseudoatrophy and mental regression on valproate and a mitochondrial DNA mutation.
Topics: Adult; Aged; Anticonvulsants; Atrophy; Brain; Child; Cognition Disorders; Developmental Disabilities | 2006 |
Valproate-induced Parkinsonism in epilepsy patients.
Topics: Adult; Anticonvulsants; Chi-Square Distribution; Epilepsy; Female; Humans; Male; Middle Aged; Parkin | 2007 |
The evaluation of thyroid functions, thyroid antibodies, and thyroid volumes in children with epilepsy during short-term administration of oxcarbazepine and valproate.
Topics: Antibodies; Anticonvulsants; Carbamazepine; Child; Drug Administration Schedule; Epilepsy; Humans; I | 2006 |
How to replace lamotrigine with valproate.
Topics: Adolescent; Adult; Anticonvulsants; Cost-Benefit Analysis; Dose-Response Relationship, Drug; Drug Ad | 2006 |
Plasma vitamin values and antiepileptic therapy: case reports of pregnancy outcomes affected by a neural tube defect.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Folic Acid; Genetic Predisposition to Disease; Homocystein | 2007 |
Serum lipid profile in children receiving anti-epileptic drug monotherapy: is it atherogenic?
Topics: Adolescent; Anticonvulsants; Apolipoproteins; Atherosclerosis; Carbamazepine; Child; Cholesterol, HD | 2006 |
The effects of carbamazepine, valproic acid and phenobarbital on the oxidative and antioxidative balance in epileptic children.
Topics: Anticonvulsants; Antioxidants; Bilirubin; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; | 2007 |
[Determination of serum valproic acid drugs by capillary electrophoresis].
Topics: Anticonvulsants; Electrophoresis, Capillary; Epilepsy; Humans; Sensitivity and Specificity; Valproic | 2006 |
The challenges of psychopharmacological management of children with severe developmental disabilities.
Topics: Anticonvulsants; Antipsychotic Agents; Autistic Disorder; Caregivers; Child; Developmental Disabilit | 2006 |
Valproic acid-induced hepatopathy: nine new fatalities in Germany from 1994 to 2003.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Chemical and Drug Induced Liver Injury; Child; Chil | 2006 |
The frequency of reversible parkinsonism and cognitive decline associated with valproate treatment: a study of 364 patients with different types of epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Cognition Disorders; Drug Administration Schedule; Drug Th | 2006 |
Distinct absorption characteristics of oral formulations of valproic acid/divalproex available in the United States.
Topics: Absorption; Administration, Oral; Anticonvulsants; Area Under Curve; Drug Combinations; Drug Compoun | 2007 |
Valproate, weight gain and carbohydrate craving: a gender study.
Topics: Adult; Anticonvulsants; Appetite; Body Mass Index; Dietary Carbohydrates; Epilepsy; Female; Glucose; | 2007 |
A 6-month longitudinal study of bone mineral density with antiepileptic drug monotherapy.
Topics: Adolescent; Adult; Anticonvulsants; Biomarkers; Bone Density; Bone Diseases, Metabolic; Calcitriol; | 2007 |
Valproic acid aggravates epilepsy due to MELAS in a patient with an A3243G mutation of mitochondrial DNA.
Topics: Adult; Anticonvulsants; DNA, Mitochondrial; Electroencephalography; Epilepsy; Humans; Magnetic Reson | 2007 |
[Valproate sodium and zonisamide associated interstitial pneumonitis in an infant].
Topics: Anticonvulsants; Epilepsy; Female; Humans; Infant; Isoxazoles; Lung Diseases, Interstitial; Respirat | 2007 |
Effects of valproate on acylcarnitines in children with epilepsy using ESI-MS/MS.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Carnitine; Chemical and Drug Induced Liver Injury; Child | 2007 |
Valproate-associated coagulopathies are frequent and variable in children.
Topics: Age Factors; Ambulatory Care; Anticonvulsants; Blood Coagulation Disorders; Child; Epilepsy; Female; | 2007 |
Effects of valproic acid on hearing in epileptic patients.
Topics: Adolescent; Anticonvulsants; Audiometry; Auditory Threshold; Case-Control Studies; Child; Drug Admin | 2007 |
Population estimation of the effects of cytochrome P450 2C9 and 2C19 polymorphisms on phenobarbital clearance in Japanese.
Topics: Adult; Algorithms; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Asian People; Cytochrome P-450 CY | 2007 |
A peculiar form of epilepsy induced by crying in infancy.
Topics: Anticonvulsants; Crying; Electroencephalography; Epilepsy; Humans; Infant; Respiration; Valproic Aci | 2007 |
[An association between the FABP2 gene polymorphism and efficacy of valproates].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alleles; Anticonvulsants; Biological Transport, Active; | 2007 |
Endocrine effects of valproate in adolescent girls with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Body Height; Body Mass Index; Child; Comorbidity; Epilepsy; Fema | 2007 |
Is valproate encephalopathy under-recognised in older people? A case series.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Diagnosis, Differential; Electroencephalography; Epilepsy; | 2007 |
A survey of antiepileptic prescribing to women of childbearing potential in psychiatry.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Prescriptions; England; Epilepsy; Female; Ho | 2007 |
Antiepileptic drugs prevent changes induced by pilocarpine model of epilepsy in brain ecto-nucleotidases.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphatases; Adenosine Triphosphate; A | 2007 |
Different clinical manifestations of hyperammonemic encephalopathy.
Topics: Adult; Anticonvulsants; Brain Diseases, Metabolic; Drug Therapy, Combination; Electroencephalography | 2007 |
Valproate is an effective, well-tolerated drug for treatment of status epilepticus/serial attacks in adults.
Topics: Adult; Aged; Aged, 80 and over; Anesthetics, General; Anticonvulsants; Dose-Response Relationship, D | 2007 |
Stevens-Johnson syndrome due to concomitant use of lamotrigine and valproic acid.
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Lamotrig | 2007 |
Sodium valproate, hyperandrogenism and altered ovarian function in Indian women with epilepsy: a prospective study.
Topics: Body Mass Index; Epilepsy; Female; Follow-Up Studies; Hirsutism; Humans; Hyperandrogenism; Indians, | 2007 |
The effect of sodium valproate on proton MRS visible neurochemical concentrations.
Topics: Adolescent; Adult; Algorithms; Anticonvulsants; Brain Chemistry; Dipeptides; Epilepsy; Female; Gluta | 2007 |
[Long latency auditory evoked potentials in schoolchildren and adolescents with epilepsy].
Topics: Adolescent; Anticonvulsants; Carbamazepine; Case-Control Studies; Child; Cognition; Epilepsy; Event- | 2006 |
[Nocturnal epilepsy associated with sleep apnea syndrome].
Topics: Circadian Rhythm; Epilepsy; Humans; Intermittent Positive-Pressure Ventilation; Male; Middle Aged; P | 2007 |
Temporal lobe epilepsy is a disease of faulty neuronal resonators rather than oscillators, and all seizures are provoked, usually by stress.
Topics: Anticonvulsants; Epilepsy; Epilepsy, Temporal Lobe; Ethosuximide; Hippocampus; Humans; Models, Neuro | 2007 |
[Clinical observation of valproate sodium-induced nocturnal enuresis].
Topics: Adult; Anticonvulsants; Child; Epilepsy; Female; Humans; Male; Nocturnal Enuresis; Valproic Acid | 2007 |
Video-EEG in syncopal attack due to ocular compression in an adolescent mistreated for epilepsy.
Topics: Adolescent; Cerebral Cortex; Diagnosis, Differential; Diagnostic Errors; Electroencephalography; Epi | 2007 |
Phenytoin but not valproate directly affected in vitro trophoblast differentiation.
Topics: Anticonvulsants; Cell Differentiation; Cells, Cultured; Dose-Response Relationship, Drug; Epilepsy; | 2008 |
Metabolic and hormonal disturbances in women with epilepsy on antiepileptic drug monotherapy.
Topics: Adolescent; Adult; Anticonvulsants; Blood Glucose; Body Mass Index; Carbamazepine; Comorbidity; Epil | 2007 |
Motor correlates of models of secondary bilateral synchrony and multiple epileptic foci.
Topics: Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Convulsants; Data Interpretation, Statistic | 2007 |
Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshock.
Topics: Acetamides; Algorithms; Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease | 2007 |
Severe bleeding complications during antiepileptic treatment with valproic acid in children.
Topics: Adolescent; Anticonvulsants; Blood Platelet Disorders; Child, Preschool; Epilepsy; Humans; Infant; I | 2007 |
Risk factors for development of subclinical hypothyroidism during valproic acid therapy.
Topics: Adolescent; Age Distribution; Case-Control Studies; Child; Child, Preschool; Cohort Studies; Dose-Re | 2007 |
Visual field defect during therapy with valproic-acid.
Topics: Adult; Epilepsy; Female; GABA Agents; gamma-Aminobutyric Acid; Humans; Retina; Retinal Degeneration; | 2007 |
Old versus new antiepileptic drugs: the SANAD study.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Lamotrigine; Triazines; Valproic Acid | 2007 |
Early intervention for the ocular and neurodevelopmental sequelae of Fetal Valproate Syndrome.
Topics: Abnormalities, Drug-Induced; Amblyopia; Anticonvulsants; Autistic Disorder; Child, Preschool; Cranio | 2007 |
Multiple system atrophy due to prolonged valproic acid treatment.
Topics: Anticonvulsants; Brain; Epilepsy; Female; Humans; Magnetic Resonance Imaging; Middle Aged; Multiple | 2007 |
Conversion to lamotrigine monotherapy from valproate monotherapy in older adolescent patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Lamo | 2007 |
Population pharmacokinetics of valproate in Chinese children with epilepsy.
Topics: Adolescent; Anticonvulsants; Bayes Theorem; Child; Child, Preschool; China; Epilepsy; Female; Humans | 2007 |
Population pharmacokinetics of valproic acid concentrations in elderly nursing home residents.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Drug Monitoring; Epilepsy; Female; Health Services for the | 2007 |
Prescribing patterns of antiepileptic drugs in Italy: a nationwide population-based study in the years 2000-2005.
Topics: Adolescent; Adult; Age Distribution; Aged; Amines; Anticonvulsants; Carbamazepine; Catchment Area, H | 2007 |
[Effect of UGT1A6 genetic polymorphisms on the metabolism of sodium valproate].
Topics: Adolescent; Adult; Base Sequence; Child; Child, Preschool; Epilepsy; Gene Frequency; Genotype; Glucu | 2007 |
Which patients become seizure free with antiepileptic drugs? An observational study in 821 patients with epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Cohort Studies; Drug Resistance; Drug Therapy, Combination; E | 2008 |
Can prolonged administration of valproic acid put patients with epilepsy at higher risk for development of Alzheimer's disease?
Topics: Alzheimer Disease; Anticonvulsants; Epilepsy; Humans; Valproic Acid | 2008 |
The Australian Register of Antiepileptic Drugs in Pregnancy: the first 1002 pregnancies.
Topics: Anticonvulsants; Australia; Birth Weight; Epilepsy; Female; Fetus; Humans; Pregnancy; Pregnancy Comp | 2007 |
Serum sodium valproate testing: is it appropriate?
Topics: Epilepsy; Evidence-Based Medicine; Female; Humans; Male; Medical Audit; Retrospective Studies; Valpr | 2007 |
Adiponectin and visfatin concentrations in children treated with valproic acid.
Topics: Adiponectin; Adipose Tissue; Age Factors; Anticonvulsants; Blood Glucose; Child; Epilepsy; Female; H | 2008 |
Encephalopathy induced by levetiracetam added to valproate.
Topics: Adult; Anticonvulsants; Brain Diseases; Electroencephalography; Epilepsy; Humans; Levetiracetam; Mal | 2008 |
Massive valproic acid overdose, a misleading case.
Topics: Adult; Ammonia; Anticonvulsants; Antidotes; Charcoal; Coma; Drug Overdose; Epilepsy; Humans; Male; P | 2008 |
[Seven cases of decreased serum valproic acid concentration during concomitant use of carbapenem antibiotics].
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Anticonvulsants; Carbapenems; Drug Interactio | 2007 |
Treatment of refractory seizures due to a benign mass present in the corpus callosum with an ion magnetic inductor: case report.
Topics: Adult; Agenesis of Corpus Callosum; Anticonvulsants; Colchicine; Combined Modality Therapy; Corpus C | 2005 |
Glutathione-S-transferase (GST) M1 null genotype and combined GSTM1 and GSTT1 null genotypes are risk factors for increased serum gamma-glutamyltransferase in valproic acid-treated patients.
Topics: Adolescent; Adult; Anticonvulsants; Child; Epilepsy; Female; gamma-Glutamyltransferase; Genotype; Gl | 2008 |
The measurement of ammonia blood levels in patients taking valproic acid: looking for problems where they do not exist?
Topics: Ammonia; Anticonvulsants; Epilepsy; Humans; Valproic Acid | 2008 |
Mixed models for ordinal data: a pharmacokinetic study on the effectiveness of drug for the reduction of epileptic seizures.
Topics: Anticonvulsants; Epilepsy; Humans; Models, Statistical; Monte Carlo Method; Treatment Outcome; Valpr | 2008 |
Homocysteine levels in epileptic children receiving antiepileptic drugs.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Folic Acid; Homocysteine; Human | 2007 |
Pharmacokinetic modeling of valproate from clinical data in Serbian epileptic patients.
Topics: Adolescent; Adult; Age Factors; Algorithms; Anticonvulsants; Biological Availability; Carbamazepine; | 2007 |
Reversible valproate hepatotoxicity due to mutations in mitochondrial DNA polymerase gamma (POLG1).
Topics: Anticonvulsants; Child, Preschool; DNA Polymerase gamma; DNA-Directed DNA Polymerase; DNA, Mitochond | 2008 |
Characterization of non-linear relationship between total and unbound serum concentrations of valproic acid in epileptic children.
Topics: Adolescent; Anticonvulsants; Binding Sites; Child; Child, Preschool; Drug Interactions; Drug Monitor | 2008 |
Evaluation of the relationship between C677T variants of methylenetetrahydrofolate reductase gene and hyperhomocysteinemia in children receiving antiepileptic drug therapy.
Topics: Adolescent; Analysis of Variance; Anticonvulsants; Carbamazepine; Child; Chromatography, High Pressu | 2008 |
Contraindications to phenytoin in emergency department patients with seizures.
Topics: Anticonvulsants; Contraindications; Emergency Service, Hospital; Epilepsy; Female; Humans; Levetirac | 2009 |
Simultaneous toxicities in a child on multiple anticonvulsants.
Topics: Anticonvulsants; Bone Marrow; Bone Marrow Diseases; Chemical and Drug Induced Liver Injury; Child, P | 2008 |
Treatment of newly diagnosed epilepsies: the shortcomings of SANAD.
Topics: Anticonvulsants; Carbamazepine; Child; Epilepsy; Follow-Up Studies; Humans; Lamotrigine; Randomized | 2008 |
Loss of astrocytic domain organization in the epileptic brain.
Topics: Amino Acids; Amyloid beta-Protein Precursor; Animals; Anticonvulsants; Astrocytes; Basic Helix-Loop- | 2008 |
[Study of oro-dental injuries during seizures in Senegalese children with epilepsy].
Topics: Accidental Falls; Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Ma | 2007 |
[Depakine in the therapy of epilepsy in children and adolescents].
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Drug; Electroencep | 2007 |
[Visual auras in idiopathic generalized epilepsy].
Topics: Adolescent; Anticonvulsants; Behavior; Electroencephalography; Epilepsy; Epilepsy, Generalized; Epil | 2008 |
Neuronal peroxisome proliferator-activated receptor gamma signaling: regulation by mood-stabilizer valproate.
Topics: Acyl-CoA Oxidase; Animals; Antimanic Agents; Bipolar Disorder; Catalase; Epilepsy; Gene Expression; | 2008 |
Bone health in young women with epilepsy after one year of antiepileptic drug monotherapy.
Topics: Adolescent; Adult; Alkaline Phosphatase; Anticonvulsants; Biomarkers; Bone Density; Bone Diseases, M | 2008 |
Fish liver oil and propolis as protective natural products against the effect of the anti-epileptic drug valproate on immunological markers of bone formation in rats.
Topics: Alkaline Phosphatase; Animals; Anticonvulsants; Atropine; Biomarkers; Bone Resorption; Disease Model | 2008 |
[The use of generic valparin xr in the treatment of epilepsy.].
Topics: Anticonvulsants; Drug Therapy, Combination; Epilepsy; Humans; Seizures; Treatment Outcome; Valproic | 2007 |
Risk of hypospadias in newborn infants exposed to valproic acid during the first trimester of pregnancy: a case-control study in Spain.
Topics: Anticonvulsants; Case-Control Studies; Epilepsy; Female; Humans; Hypospadias; Infant, Newborn; Logis | 2008 |
Our work is still cut out for us...
Topics: Anticonvulsants; Carbamazepine; Child; Data Collection; Epilepsy; Expert Testimony; Guidelines as To | 2008 |
Inverse correlation of valproic acid serum concentrations and quality of life in adolescents with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Child; Epilepsy; Female; Humans; Male; Quality of Life; Statisti | 2008 |
Valproic acid during pregnancy.
Topics: Epilepsy; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complications; Valproic Acid | 1980 |
Secondary hyperammonaemia: a possible mechanism for valproate encephalopathy.
Topics: Ammonia; Brain; Brain Diseases; Child, Preschool; Epilepsy; Female; Humans; Propionates; Valproic Ac | 1980 |
Psychiatric implications of anticonvulsant drugs.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Dose-Response Relationship, Dr | 1980 |
Acute liver disease associated with sodium valproate.
Topics: Acute Disease; Adult; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Epilepsy; Fat | 1980 |
Sodium valproate and the liver.
Topics: Chemical and Drug Induced Liver Injury; Child; Epilepsy; Humans; Liver; Liver Diseases; Valproic Aci | 1980 |
Diurnal fluctuation of serum level of sodium valproate and interaction with neuroleptics.
Topics: Adolescent; Adult; Antipsychotic Agents; Circadian Rhythm; Drug Interactions; Epilepsy; Female; Huma | 1980 |
Drug safety in porphyria: risks of valproate and metoclopramide.
Topics: Adolescent; Epilepsy; Female; Humans; Metoclopramide; Porphyrias; Valproic Acid | 1981 |
Choice of anticonvulsants in epilepsy.
Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Child, Preschool | 1981 |
New anticonvulsant drugs.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Epilepsy; gamma-Aminobutyric A | 1980 |
Co-trimoxazole prophylaxis in leukaemia.
Topics: Child; Drug Combinations; Drug Synergism; Epilepsy; Humans; Leukemia, Lymphoid; Sulfamethoxazole; Tr | 1982 |
Valproate levels in children with epilepsy.
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Valproic Acid | 1982 |
Maternal valproic acid and congenital neural tube defects.
Topics: Epilepsy; Female; Humans; Maternal-Fetal Exchange; Neural Tube Defects; Pregnancy; Valproic Acid | 1982 |
Valproic acid and spina bifida.
Topics: Epilepsy; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange; Pregn | 1982 |
Valproate and malformations.
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pre | 1982 |
[The effect of valproate monotherapy on the activities of liver enzymes in epileptic children and adolescents].
Topics: Adolescent; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Child; Enzymes; | 1982 |
The influence of antiepileptic drugs on the electroencephalogram: a review of controlled clinical studies.
Topics: Anti-Anxiety Agents; Anticonvulsants; Brain; Carbamazepine; Clonazepam; Electroencephalography; Epil | 1982 |
[Rise in gamma-GT during anticonvulsive therapy].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combinatio | 1982 |
Valproic acid and spina bifida.
Topics: Adult; Anencephaly; Epilepsy; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complications; S | 1983 |
Possible hazard of valpromide-carbamazepine combination therapy in epilepsy.
Topics: Anticonvulsants; Carbamazepine; Drug Synergism; Drug Therapy, Combination; Epilepsy; Humans; Valproi | 1984 |
Pharmacokinetics of antiepileptic drugs.
Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Child; Child, Preschool | 1983 |
Hepatitis A in three patients taking sodium valproate.
Topics: Adult; Child; Epilepsy; Female; Hepatitis A; Humans; Liver; Valproic Acid | 1984 |
Pharmacodynamic factors in the occurrence of psychiatric symptoms among patients with epilepsy.
Topics: Anticonvulsants; Barbiturates; Carbamazepine; Epilepsy; Folic Acid; Humans; Kinetics; Mental Disorde | 1983 |
Valproic acid increases gamma-aminobutyric acid in CSF of epileptic children.
Topics: Animals; Brain; Child; Epilepsy; gamma-Aminobutyric Acid; Humans; Valproic Acid | 1984 |
Spina bifida and in-utero exposure to valproate.
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complications; Spina Bif | 1984 |
Valproate and spina bifida.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Epilepsy; Female; Humans; Middle Aged; Pregnancy; Pr | 1984 |
Electroencephalographic and behavioural effects of sodium valproate in patients with photosensitive epilepsy. A single dose trial.
Topics: Adolescent; Adult; Child; Epilepsy; Evoked Potentials; Female; Humans; Light; Male; Valproic Acid | 1980 |
Plasma concentrations of valproate during maintenance therapy in epileptic children.
Topics: Adolescent; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Epilepsy, A | 1982 |
[Monotherapy with sodium valproate in generalized primary epilepsy. 2d phase: Study of long-term efficacy and tolerance].
Topics: Adult; Amylases; Body Weight; Drug Tolerance; Epilepsy; Female; Humans; Male; Middle Aged; Pregnancy | 1983 |
Plasma arginine vasopressin concentrations in epileptics under monotherapy.
Topics: Adult; Anticonvulsants; Arginine Vasopressin; Carbamazepine; Epilepsy; Humans; Phenytoin; Primidone; | 1983 |
Pattern-reversal visual evoked potentials in photosensitive epilepsy.
Topics: Adolescent; Adult; Epilepsy; Evoked Potentials, Visual; Female; Form Perception; Humans; Light; Male | 1984 |
Sodium valproate and corticotropin suppression in the child treated for seizures.
Topics: Adrenocorticotropic Hormone; Adult; Child; Epilepsy; Humans; Hydrocortisone; Valproic Acid | 1983 |
Valproic acid and fetal abnormality.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Epilepsy; Female; Humans; Infant, Newbo | 1983 |
[Biochemical aspects of pathophysiology and treatment of intractable epilepsy in children].
Topics: Adrenocorticotropic Hormone; Animals; Child; Child, Preschool; Epilepsy; Humans; Indoles; Male; Pyri | 1983 |
The treatable epilepsies.
Topics: Adrenocorticotropic Hormone; Child; Epilepsy; Humans; Phenytoin; Spasms, Infantile; Valproic Acid | 1983 |
Valproic acid and metabolites: pharmacological and toxicological studies.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Chemical and Drug Induced Liver Injury; Chemical Phenom | 1984 |
Valproate: recent findings and perspectives.
Topics: Chemical Phenomena; Chemistry; Epilepsy; gamma-Aminobutyric Acid; Humans; Ion Channels; Membrane Pot | 1984 |
Valproic acid: update on its mechanisms of action.
Topics: Brain; Drug Synergism; Epilepsy; gamma-Aminobutyric Acid; Humans; Ion Channels; Membrane Potentials; | 1984 |
Valproic acid and intractable seizures in severely brain-damaged patients.
Topics: Adolescent; Adult; Brain Damage, Chronic; Child; Epilepsy; Female; Humans; Male; Middle Aged; Valpro | 1983 |
Hazard of video games in patients with light-sensitive epilepsy.
Topics: Adolescent; Electroencephalography; Epilepsy; Humans; Light; Male; Photic Stimulation; Play and Play | 1983 |
[Sodium valproate: a hyperammonemic drug. Study in the epileptic and healthy volunteer].
Topics: Ammonia; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; | 1983 |
Spina bifida and sodium valproate.
Topics: Epilepsy; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complications; Spina Bifida Occulta; | 1983 |
The effect of chronic anticonvulsant therapy on serum lipids and lipoproteins in epileptic children.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cholesterol; Epilepsy; Humans; | 1983 |
[Spina bifida caused by valproic acid?].
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complic | 1983 |
Carbamazepine and valproic acid.
Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug In | 1983 |
Transplacental passage and half-life of sodium valproate in infants born to epileptic mothers.
Topics: Epilepsy; Female; Fetal Blood; Half-Life; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pregnanc | 1983 |
Serum thyroid hormones and blood folic acid during monotherapy with carbamazepine or valproate. A controlled study.
Topics: Adolescent; Adult; Aged; Carbamazepine; Epilepsy; Folic Acid; Humans; Middle Aged; Thyroid Hormones; | 1983 |
Free and bound valproic acid separated by two methods of ultrafiltration.
Topics: Epilepsy; Humans; Immunoenzyme Techniques; Ultrafiltration; Valproic Acid | 1983 |
The effects of peritoneal dialysis on the single dose and steady state pharmacokinetics of valproic acid in a uremic epileptic child.
Topics: Child; Epilepsy; Half-Life; Humans; Kinetics; Peritoneal Dialysis; Uremia; Valproic Acid | 1983 |
[Ataractic treatment in psychiatry and general medicine. 2. Tranquillant = tranquilizers = daytime sedatives].
Topics: Anticonvulsants; Antidepressive Agents; Benzodiazepines; Carbamazepine; Chemistry, Pharmaceutical; C | 1983 |
Oral state of children with epilepsy on treatment with sodium valproate.
Topics: Adolescent; Child; Dental Plaque; Epilepsy; Gingivitis; Humans; Mouth Diseases; Oral Hygiene; Valpro | 1983 |
Diurnal fluctuations in free and total plasma concentrations of valproic acid at steady state in epileptic patients.
Topics: Adolescent; Adult; Child; Circadian Rhythm; Dose-Response Relationship, Drug; Drug Therapy, Combinat | 1983 |
Valproic acid free fraction in epileptic children under chronic monotherapy.
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Time Factors; Valproic Acid | 1983 |
Treatment of epilepsy in women of child-bearing age: patients' opinion of teratogenic potential of valproate.
Topics: Adolescent; Adult; Attitude; Drug Therapy, Combination; Epilepsy; Female; Humans; Infant, Newborn; M | 1983 |
Antiepileptic drugs and teratogenesis. How should patients, doctors and health authorities be counselled?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Infant, Newbo | 1983 |
Active metabolites in antiepileptic therapy. Reflections on a pharmacological joker.
Topics: Anticonvulsants; Biotransformation; Carbamazepine; Diazepam; Epilepsy; Humans; Kinetics; Primidone; | 1983 |
Intoxication with sodium valproate. A case report.
Topics: Adolescent; Bilirubin; Epilepsy; Female; Humans; Valproic Acid | 1983 |
[Case of congenital anomalies born to an epileptic woman treated with valproic acid and phenobarbital].
Topics: Abnormalities, Drug-Induced; Ear, External; Epilepsy; Esotropia; Female; Humans; Infant; Phenobarbit | 1983 |
Drugs for epilepsy.
Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy; Humans; Phenobarbital; Phenytoin; Statu | 1983 |
Chronic valproate administration reduces fasting ketonemia in children.
Topics: Child; Child, Preschool; Epilepsy; Fasting; Humans; Hydroxybutyrates; Ketone Bodies; Liver Glycogen; | 1983 |
[Is valproic acid teratogenic?].
Topics: Abnormalities, Drug-Induced; Adult; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Infa | 1983 |
Twice-daily dosing of valproate with divalproex.
Topics: Absorption; Adolescent; Adult; Child; Delayed-Action Preparations; Drug Evaluation; Epilepsy; Female | 1983 |
Value of Mongolian gerbils in antiepileptic drug evaluation.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation; Epilepsy; Gerbillinae; Seizures; | 1983 |
Sodium valproate associated with phenobarbital: effects on ammonia metabolism in humans.
Topics: Adult; Ammonia; Epilepsy; Female; Humans; Kidney; Liver; Male; Middle Aged; Phenobarbital; Valproic | 1983 |
Treatment of the nonconvulsive epilepsies.
Topics: Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Humans; Phenobarbi | 1983 |
Intra-daily oscillations in dipropylacetic acid plasma levels with two or three daily doses of dipropylacetamide in epileptic patients.
Topics: Adolescent; Adult; Child; Circadian Rhythm; Drug Administration Schedule; Epilepsy; Female; Humans; | 1983 |
Possible teratogenic effect of valproate during pregnancy.
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pre | 1983 |
Valproate-induced hyperammonemia in asymptomatic children.
Topics: Adolescent; Adult; Ammonia; Child; Child, Preschool; Epilepsy; Humans; Infant; Liver; Valproic Acid | 1983 |
[Pharmacotherapy of epilepsy--current problems and controversies].
Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Epilepsies, Partial; Epilepsy; Epilepsy, | 1983 |
Treatment of epileptic patients with valproic acid does not modify plasma and urine short-chain-fatty acids.
Topics: Adolescent; Adult; Ammonia; Brain Diseases; Butyrates; Epilepsy; Fatty Acids; Female; Hemiterpenes; | 1983 |
[Correlation among sodium valproate concentrations in the total blood, plasma ultrafiltrate, and cerebrospinal fluid].
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Valproic Acid | 1983 |
Should we routinely measure free plasma phenytoin concentration?
Topics: Adolescent; Adult; Aged; Blood Proteins; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Pro | 1984 |
Sodium valproate re epilepsy.
Topics: Child; Epilepsy; Humans; Hydrocortisone; Valproic Acid | 1984 |
[Role of hyperammonemia in stuporous states induced by sodium valproate].
Topics: Adult; Ammonia; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Female; Glutamine; Humans; U | 1983 |
Unnecessary polypharmacy in patients with frequent seizures.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Drug Therapy, Combination; Epi | 1984 |
Intensive follow-up monitoring in patients with once daily evening administration of sodium valproate.
Topics: Adolescent; Adult; Child; Drug Administration Schedule; Electroencephalography; Epilepsy; Female; Hu | 1984 |
Protein binding of valproic acid in maternal and umbilical cord serum.
Topics: Adolescent; Adult; Blood Proteins; Epilepsy; Female; Fetal Blood; Humans; Pregnancy; Pregnancy Compl | 1984 |
Valproic acid in the perinatal period: decreased maternal serum protein binding results in fetal accumulation and neonatal displacement of the drug and some metabolites.
Topics: Blood Proteins; Epilepsy; Fatty Acids, Nonesterified; Female; Fetal Blood; Fetus; Humans; Infant, Ne | 1984 |
Pharmacokinetics of enteric-coated valproic acid.
Topics: Adult; Biological Availability; Capsules; Epilepsy; Female; Humans; Kinetics; Male; Tablets, Enteric | 1984 |
Side effects of carbamazepine, valproate and clonazepam during long-term treatment of epilepsy.
Topics: Abnormalities, Drug-Induced; Arousal; Benzodiazepinones; Carbamazepine; Chemical and Drug Induced Li | 1983 |
Hepatic toxicity of antiepileptic drugs: a review.
Topics: Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury; Energy Metabolism; Epilepsy; | 1983 |
[Platelet dysfunction in children during treatment with sodium valproate].
Topics: Adolescent; Age Factors; Blood Platelets; Child; Child, Preschool; Epilepsy; Female; Humans; Male; P | 1984 |
Open trials with valproate in epilepsy.
Topics: Drug Therapy; Epilepsies, Myoclonic; Epilepsy; Epilepsy, Temporal Lobe; Humans; Valproic Acid | 1984 |
Non-dose-related side effects of valproate.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Aged; Child; Child, Preschool; Epilepsy; Fat Necrosi | 1984 |
Sodium valproate and cognitive function.
Topics: Adolescent; Adult; Child; Cognition; Epilepsy; Humans; Psychological Tests; Valproic Acid | 1984 |
Rational use of valproate: indications and drug regimen in epilepsy.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Child, | 1984 |
Valproate monotherapy.
Topics: Anticonvulsants; Drug Therapy; Epilepsy; Humans; Valproic Acid | 1984 |
Valproic acid and congenital malformations. A case report.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Epilepsy; Female; Humans; Infant, Newbo | 1984 |
Carbamazepine/valproic acid interaction in man and rhesus monkey.
Topics: Adolescent; Adult; Animals; Carbamazepine; Child; Dose-Response Relationship, Drug; Drug Interaction | 1984 |
Hyperammonemia and valproate-induced alterations of the state of consciousness. A report of 8 cases.
Topics: Adult; Ammonia; Epilepsy; Female; Humans; Male; Unconsciousness; Valproic Acid | 1984 |
Effect of anticonvulsant drugs on thalamo-cortical and hippocampo-cortical self-sustained after-discharges in the rat.
Topics: Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Electric Stimulation; Electroencephalograp | 1984 |
Comparative evaluation of anticonvulsant and toxic potencies of valproic acid and 2-en-valproic acid in different animal models of epilepsy.
Topics: Animals; Anticonvulsants; Electroshock; Epilepsy; Fatty Acids, Monounsaturated; Fatty Acids, Unsatur | 1984 |
Five doubly unsaturated metabolites of valproic acid in urine and plasma of patients on valproic acid therapy.
Topics: Epilepsy; Fatty Acids, Unsaturated; Gas Chromatography-Mass Spectrometry; Humans; Valproic Acid | 1984 |
Lack of significant correlation between circadian profiles of valproic acid serum levels and epileptiform electroencephalographic activity.
Topics: Adolescent; Adult; Circadian Rhythm; Electroencephalography; Epilepsy; Female; Humans; Male; Middle | 1984 |
The effects of carbamazepine and valproate on folate metabolism in man.
Topics: Adolescent; Adult; Carbamazepine; Epilepsy; Female; Folic Acid; gamma-Glutamyl Hydrolase; Humans; In | 1984 |
Potentiation of the anticonvulsant effects of antiepileptic drugs by "nootropics"; a potential new therapeutic approach.
Topics: Animals; Anticonvulsants; Carbamazepine; Clonazepam; Dose-Response Relationship, Drug; Drug Synergis | 1984 |
Summing up of the success so far gained through choice of drugs or combinations of drugs.
Topics: Adult; Anticonvulsants; Carbamazepine; Cognition Disorders; Drug Therapy, Combination; Epilepsy; Hum | 1984 |
Effect of valproate on free plasma phenytoin concentrations.
Topics: Adult; Binding, Competitive; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Protein Binding | 1984 |
[The incidence of postoperative epilepsy and prophylactic anticonvulsants in patients with intracranial aneurysm].
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; In | 1984 |
Valproate treatment and carnitine deficiency.
Topics: Animals; Carnitine; Epilepsy; Liver; Muridae; Valproic Acid | 1984 |
Rectal administration of sodium valproate in children.
Topics: Administration, Oral; Age Factors; Catheterization; Child; Child, Preschool; Epilepsy; Half-Life; Hu | 1984 |
Nonsedative regimens in the treatment of epilepsy.
Topics: Carbamazepine; Epilepsy; Ethosuximide; Humans; Phenytoin; Seizures; Valproic Acid | 1983 |
Weight gain during treatment with valproate.
Topics: Adult; Aged; Body Weight; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Middle Aged; Va | 1984 |
Sodium valproate and routine liver function tests.
Topics: Chemical and Drug Induced Liver Injury; Child; Epilepsy; Humans; Liver Diseases; Liver Function Test | 1984 |
A comparative study of the relative enzyme inducing properties of anticonvulsant drugs in epileptic patients.
Topics: Anticonvulsants; Antipyrine; Carbamazepine; Enzyme Induction; Epilepsy; Female; Glucaric Acid; Half- | 1984 |
Acute changes of blood ammonia may predict short-term adverse effects of valproic acid.
Topics: Adolescent; Adult; Ammonia; Child; Consciousness Disorders; Epilepsy; Female; Humans; Male; Middle A | 1984 |
[Plasma levels of antiepileptic agents in the treatment of epilepsy].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Drug Interac | 1984 |
[Combination therapy with carbamazepine and valproic acid in problem cases at an outpatient epilepsy clinic].
Topics: Adult; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsy; Female; | 1984 |
Electrically elicited seizures from the inferior colliculus: a potential site for the genesis of epilepsy?
Topics: Animals; Chlordiazepoxide; Electric Stimulation; Electrophysiology; Epilepsy; Inferior Colliculi; Ma | 1984 |
The fetal valproate syndrome.
Topics: Epilepsy; Face; Female; Heart Defects, Congenital; Humans; Infant, Low Birth Weight; Infant, Newborn | 1984 |
Steady-state valproate pharmacokinetics during long term therapy.
Topics: Adolescent; Adult; Biological Availability; Child; Epilepsy; Half-Life; Humans; Kinetics; Metabolic | 1983 |
Anticonvulsant effects on the memory performance of epileptics.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Intelligence; Memory; Memory Di | 1984 |
Anticonvulsants, folic acid and memory dysfunction in epileptics.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Erythrocytes; Folic Acid; Humans; Memor | 1984 |
Sodium valproate in the treatment of childhood epilepsies.
Topics: Child; Child, Preschool; Electroencephalography; Epilepsy; Humans; Infant; Infant, Newborn; Spasms, | 1984 |
Clinical implications of serum protein binding in epileptic children during sodium valproate maintenance therapy.
Topics: Adult; Blood Proteins; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Kinetics; Male; Pr | 1984 |
Free valproic acid: steady-state pharmacokinetics in patients with intractable epilepsy.
Topics: Adolescent; Adult; Child; Child, Preschool; Epilepsy; Female; Humans; Kinetics; Male; Metabolic Clea | 1984 |
Altered ratio of carbamazepine-10,11-epoxide/carbamazepine in plasma of children: evidence of anticonvulsant drug interaction.
Topics: Anticonvulsants; Carbamazepine; Child; Chromatography, Gas; Chromatography, High Pressure Liquid; Dr | 1984 |
Correlation between plasma carbamazepine-10,11-epoxide concentration and drug side-effects in children with epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Epil | 1984 |
[Use of valproic acid in pregnancy: an indication for prenatal diagnosis of spina bifida].
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complic | 1984 |
[Use of valproic acid by pregnant women with epilepsy and the risk of congenital abnormalities in the child].
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complic | 1984 |
Venous blood ammonia concentrations in adult epileptic patients are increased by treatment with valproic acid.
Topics: Adult; Ammonia; Epilepsy; Female; Humans; Male; Middle Aged; Valproic Acid | 1984 |
Sodium valproate and platelet counts.
Topics: Epilepsy; Humans; Platelet Count; Thrombocytopenia; Valproic Acid | 1980 |
Dipropylacetate and aminoaciduria.
Topics: Adolescent; Adult; Amino Acids; Child; Child, Preschool; Epilepsy; Humans; Middle Aged; Renal Aminoa | 1980 |
[Anticonvulsive combined therapy (author's transl)].
Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epileps | 1980 |
Once-daily sodium valproate in the treatment of epilepsy.
Topics: Adolescent; Adult; Child; Drug Administration Schedule; Epilepsy; Humans; Valproic Acid | 1980 |
Prophylaxis against febrile convulsions.
Topics: Child, Preschool; Diagnosis, Differential; Epilepsy; Humans; Infant; Phenobarbital; Seizures; Seizur | 1980 |
The effect of chronic N-dipropylacetamide ("depamide") treatment on plasmatic immunoglobulins of epileptic patients.
Topics: Adolescent; Adult; Anticonvulsants; Child; Epilepsy; Female; Humans; Immunoglobulin A; Immunoglobuli | 1980 |
[Autoallergic drug exanthemas].
Topics: Autoimmune Diseases; Child; Epilepsy; Female; Humans; Lupus Erythematosus, Systemic; Male; Pemphigus | 1980 |
Clinical experience with sodium valproate in children.
Topics: Adolescent; Child; Child, Preschool; Drug Evaluation; Epilepsies, Myoclonic; Epilepsy; Epilepsy, Abs | 1980 |
Sodium valproate and acute hepatic failure.
Topics: Chemical and Drug Induced Liver Injury; Child; Drug Therapy, Combination; Epilepsy; Humans; Valproic | 1980 |
A rapid and simple gas-liquid chromatographic determination of valproic acid (alpha-propyl-valeric acid) in serum.
Topics: Epilepsy; Flame Ionization; Humans; Valproic Acid | 1980 |
[Severe liver damage following administration of valproic acid (Depakine)].
Topics: Anticonvulsants; Chemical and Drug Induced Liver Injury; Child; Epilepsy; Female; Humans; Liver; Val | 1980 |
Variable in vivo binding of valproic acid in epilepsy patients being medicated with other anticonvulsants.
Topics: Binding, Competitive; Epilepsy; Humans; Phenytoin; Serum Albumin; Valproic Acid | 1980 |
Therapeutic alternatives in phenytoin-induced gingival hyperplasia. A case report and discussion.
Topics: Adolescent; Epilepsy; Female; Gingival Hyperplasia; Humans; Phenytoin; Primidone; Valproic Acid | 1980 |
Binding of drugs to human serum albumin. XIV. The theoretical basis for the interaction between phenytoin and valproate.
Topics: Adolescent; Binding, Competitive; Blood Proteins; Child; Epilepsy; Humans; Phenytoin; Protein Bindin | 1980 |
Simplified simultaneous determination of valproic acid and ethosuximide in serum by gas-liquid chromatography.
Topics: Chromatography, Gas; Epilepsy; Ethosuximide; Humans; Valproic Acid | 1980 |
Interaction between phenytoin and valproate.
Topics: Blood Proteins; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Phenytoin; Protein B | 1980 |
[Problems of therapeutic service in valproate therapy].
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsy; Humans | 1980 |
Determination of valproic acid kinetics in patients during maintenance therapy using a tetradeuterated form of the drug.
Topics: Epilepsy; Gas Chromatography-Mass Spectrometry; Half-Life; Humans; Valproic Acid | 1980 |
Pharmacokinetics of anticonvulsant drugs.
Topics: Anticonvulsants; Binding, Competitive; Brain; Carbamazepine; Drug Interactions; Drug Tolerance; Epil | 1980 |
Prophylaxis and febrile convulsions.
Topics: Child; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Phenobarbital; Recurrence; Seizures; Se | 1981 |
Drug interactions in epilepsy.
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Humans; Isoniazid; P | 1980 |
Mechanism of valproate-phenobarbital interaction in epileptic patients.
Topics: Adolescent; Adult; Child; Drug Interactions; Epilepsy; Female; Humans; Kinetics; Male; Phenobarbital | 1981 |
Concentration of metabolites of valproic acid in plasma of epileptic patients.
Topics: Adolescent; Adult; Biotransformation; Chromatography, Gas; Epilepsy; Female; Humans; Male; Middle Ag | 1981 |
Effects of sodium valproate administered acutely I.V. on human and experimental EEG epileptic foci.
Topics: Animals; Brain; Electroencephalography; Epilepsy; Humans; Rabbits; Seizures; Valproic Acid | 1980 |
Valproic acid in childhood epilepsy: anticonvulsive efficacy in relation to its plasma levels.
Topics: Adolescent; Child; Drug Therapy, Combination; Epilepsy; Humans; Phenobarbital; Valproic Acid | 1980 |
Valproate-induced stomatitis.
Topics: Adult; Epilepsy; Female; Humans; Nicotinic Acids; Stomatitis; Valproic Acid | 1981 |
[Results of treatment of epilepsy with Convulex].
Topics: Adolescent; Adult; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Middle Aged; Valproic Ac | 1980 |
Drug treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Electroencephalography; Epilepsy; Ethosuximide; Female; | 1981 |
Valproic acid disposition in epileptic patients during combined antiepileptic maintenance therapy.
Topics: Adolescent; Adult; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Metabolic Clearance Ra | 1981 |
[Daily fluctuations of plasma diphenylhydantoin in patients treated with diphenylhydantoin and sodium valproate].
Topics: Adult; Circadian Rhythm; Drug Therapy, Combination; Epilepsy; Humans; Phenytoin; Valproic Acid | 1981 |
[A neuro-immunological hypothesis for some forms of epilepsy].
Topics: Adolescent; Adult; Carbamazepine; Epilepsy; Humans; Hydantoins; Immunoglobulins; Immunologic Deficie | 1981 |
[The use of dipropylacetamide in antiepileptic therapy. Pharmacological and clinical aspects].
Topics: Epilepsy; Humans; Valproic Acid | 1981 |
Valproic acid fails to displace phenobarbitone and carbamazepine from plasma protein binding sites in epileptic patients.
Topics: Adolescent; Adult; Binding, Competitive; Blood Proteins; Carbamazepine; Epilepsy; Female; Humans; Ma | 1981 |
The effect of concurrent administration of valproate sodium on phenobarbital plasma concentration/dosage ratio in pediatric patients.
Topics: Adolescent; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Inf | 1981 |
Plasma GABA levels in neurological patients under treatment with valproic acid.
Topics: Adult; Aged; Epilepsy; gamma-Aminobutyric Acid; Humans; Male; Middle Aged; Time Factors; Valproic Ac | 1981 |
Lack of effect of valproate on paracetamol (acetaminophen) disposition in epileptic patients.
Topics: Acetaminophen; Adult; Drug Interactions; Epilepsy; Humans; Kinetics; Male; Valproic Acid | 1981 |
Effects of sodium valproate in 100 children with special reference to weight.
Topics: Adolescent; Appetite; Body Weight; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; | 1981 |
Pharmacology of valproic acid in children with severe epilepsy: clearance and hepatotoxicity.
Topics: Adolescent; Adult; Aspartate Aminotransferases; Child; Child, Preschool; Epilepsy; Humans; Liver Fun | 1981 |
[Mg valproate plasma levels in epileptic patients, measured by gas-liquid chromatography (author's transl)].
Topics: Chromatography, Gas; Epilepsy; Humans; Valproic Acid | 1981 |
[Daily plasma fluctuations of diphenylhydantoin in patients treated with diphenylhydantoin and sodium valproate].
Topics: Adult; Epilepsy; Humans; Phenytoin; Time Factors; Valproic Acid | 1981 |
[The use of dipropylacetamide in anti-epileptic therapy. Pharmacological and clinical aspects].
Topics: Epilepsy; Humans; Valproic Acid | 1981 |
Recent advances in the treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epilepsy; Female; Huma | 1980 |
Sodium valproate reassessed.
Topics: Adult; Epilepsy; Humans; Liver; Valproic Acid | 1981 |
Serum protein binding of diazepam and its displacement by valproic acid in vitro.
Topics: Binding, Competitive; Diazepam; Epilepsy; Humans; In Vitro Techniques; Serum Albumin; Valproic Acid | 1981 |
Rapid gas chromatographic determination of valproic acid in serum.
Topics: Chromatography, Gas; Epilepsy; Humans; Valproic Acid | 1981 |
Valproic acid and its metabolites: placental transfer, neonatal pharmacokinetics, transfer via mother's milk and clinical status in neonates of epileptic mothers.
Topics: Abnormalities, Drug-Induced; Aminopyrine; Breath Tests; Epilepsy; Female; Fetal Blood; Half-Life; Hu | 1981 |
[Complications of valproic acid therapy: an overview (author's transl)].
Topics: Adult; Alcohol Withdrawal Delirium; Chemical and Drug Induced Liver Injury; Child; Coma; Electroence | 1981 |
Sodium valproate in pregnancy.
Topics: Adult; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complications; Valproic Acid | 1981 |
[Tremor in the course of sodium valproate treatment].
Topics: Age Factors; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Tremor; Valproic Acid | 1981 |
Phenytoin-valproate interaction: importance of saliva monitoring in epilepsy.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Drug Interactions; Drug Therapy, Combination; Epil | 1982 |
Valproic acid and several metabolites: quantitative determination in serum, urine, breast milk and tissues by gas chromatography-mass spectrometry using selected ion monitoring.
Topics: Adult; Animals; Epilepsy; Female; Gas Chromatography-Mass Spectrometry; Humans; Infant, Newborn; Mic | 1981 |
Depamide: a preliminary report on its therapeutic efficacy in epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Behavior; Child; Drug Evaluation; Drug Interactions; Electroence | 1980 |
Sodium dipropylacetate (Vupral Polfa) in therapy of resistant epilepsy.
Topics: Adolescent; Adult; Drug Resistance; Electroencephalography; Epilepsy; Female; Humans; Male; Middle A | 1980 |
Daily fluctuations of dipropylacetate (DPA) serum level in epileptic patients.
Topics: Adolescent; Adult; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Middle | 1980 |
A computer analysis of specific and aspecific interictal epileptic activity in man.
Topics: Computers; Electroencephalography; Epilepsy; Humans; Phenobarbital; Valproic Acid | 1980 |
[Sodium valproate, platelet dysfunction and bleeding (author's transl)].
Topics: Blood Platelet Disorders; Epilepsy; Humans; Thrombocytopenia; Valproic Acid | 1981 |
Serial free and plasma valproic acid and phenytoin monitoring and drug interactions.
Topics: Adolescent; Adult; Circadian Rhythm; Drug Interactions; Epilepsy; Female; Humans; Male; Phenytoin; V | 1981 |
Dipropylacetic acid plasma levels; diurnal fluctuations during chronic treatment with dipropylacetamide.
Topics: Adolescent; Adult; Anticonvulsants; Child; Circadian Rhythm; Epilepsy; Humans; Valproic Acid | 1981 |
[Relation between plasma levels of valproic acid alone and its efficacy and toxicity in pediatric patients under chronic treatment].
Topics: Child; Child, Preschool; Drug Evaluation; Epilepsy; Humans; Infant; Seizures; Seizures, Febrile; Val | 1981 |
The free fraction of valproic acid in tears, saliva, and cerebrospinal fluid.
Topics: Adult; Child; Epilepsy; Humans; Immunoenzyme Techniques; Protein Binding; Saliva; Tears; Valproic Ac | 1982 |
Plasma levels and pharmacokinetics of antipileptic drugs in children.
Topics: Adolescent; Age Factors; Anticonvulsants; Biological Availability; Biotransformation; Carbamazepine; | 1981 |
Rapid and simple GLC determination of valproic acid and ethosuximide in plasma of epileptic patients.
Topics: Chromatography, Gas; Epilepsy; Ethosuximide; Humans; Valproic Acid | 1982 |
Free sodium valproate monitoring.
Topics: Adolescent; Adult; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Middle Aged; Time Factor | 1982 |
Increased serum phospholipids in epileptic children treated with phenobarbitone.
Topics: Child; Child, Preschool; Epilepsy; Female; Humans; Male; Phenobarbital; Phospholipids; Valproic Acid | 1982 |
Saliva and serum valproic acid levels in epileptic children.
Topics: Child; Epilepsy; Female; Humans; Male; Saliva; Valproic Acid | 1982 |
Differentiating between organic and functional seizures: a common diagnostic problem.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Diagnosis, Differential; Dose-Response Relationsh | 1981 |
[Clinical irrelevance of the hematologic side effects of sodium valproate (Depakine)].
Topics: Adult; Age Factors; Anticonvulsants; Autoantibodies; Blood Coagulation Disorders; Blood Platelets; C | 1981 |
Interaction between valproic acid and aspirin in epileptic children: serum protein binding and metabolic effects.
Topics: Aspirin; Blood Proteins; Child; Child, Preschool; Drug Interactions; Epilepsy; Female; Humans; Kinet | 1982 |
Side effects of sodium valproate in monotherapy controlled by plasma levels: a study in 88 pediatric patients.
Topics: Child; Child Behavior Disorders; Child, Preschool; Digestive System Diseases; Epilepsy; Female; Hair | 1982 |
Diurnal oscillations in plasma protein binding of valproic acid.
Topics: Adolescent; Adult; Blood Proteins; Circadian Rhythm; Epilepsy; Fatty Acids, Nonesterified; Female; H | 1982 |
Stuporous episodes during treatment with sodium valproate: report of seven cases.
Topics: Anticonvulsants; Cognition Disorders; Consciousness Disorders; Electroencephalography; Epilepsy; Fem | 1982 |
Valproate-induced hyperammonemia.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Ammonia; Anticonvulsants; Carbamoyl-Phosphate Synt | 1982 |
American Academy of Pediatrics Committee on Drugs: Valproic acid: benefits and risks.
Topics: Abnormalities, Drug-Induced; Animals; Drug Interactions; Epilepsy; Humans; Valproic Acid | 1982 |
Monitoring free valproic acid in epilepsy patients medicated with coanticonvulsants.
Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Phenytoin; Valpro | 1982 |
Treatment of primary reading epilepsy with valproic acid.
Topics: Adult; Electroencephalography; Epilepsy; Female; Humans; Reading; Valproic Acid | 1982 |
The effects of anticonvulsants on memory function in epileptic patients: preliminary findings.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Memory; Memory, Short-Term; Mental Recall; Phenyto | 1981 |
["Fever convulsions" in children. Current viewpoints on diagnosis, therapy and prognosis].
Topics: Child, Preschool; Diagnosis, Differential; Diazepam; Epilepsy; Humans; Infant; Parents; Phenobarbita | 1982 |
[Clinical evaluation of certain modern antiepileptic preparations].
Topics: Anticonvulsants; Automatism; Carbamazepine; Child; Clonazepam; Diencephalon; Epilepsy; Epilepsy, Abs | 1982 |
Clinical and pharmacokinetic observations on sodium valproate - a 5-year follow-up study in 100 children with epilepsy.
Topics: Adolescent; Child; Child, Preschool; Dose-Response Relationship, Drug; Electroencephalography; Epile | 1982 |
Sodium valproate in the treatment of the intractable childhood epileptic.
Topics: Adolescent; Adult; Child; Child, Preschool; Chronic Disease; Drug Therapy, Combination; Education of | 1982 |
Valproic acid and immune thrombocytopenia.
Topics: Adolescent; Adult; Anticonvulsants; Blood Platelets; Child; Child, Preschool; Drug Therapy, Combinat | 1982 |
Intra-dose variation in plasma protein binding of sodium valproate in epileptic patients.
Topics: Adolescent; Adult; Blood Proteins; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Male; | 1982 |
[Dipropyl-N-acetate (Convulex) in the treatment of epileptic seizures in childhood (5-year clinical experience)].
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Valproic Acid | 1982 |
Valproic acid and spina bifida: a preliminary report--France.
Topics: Epilepsy; Female; France; Humans; Infant, Newborn; Maternal-Fetal Exchange; Pregnancy; Spina Bifida | 1982 |
Antipyrine disposition in relation to lowered anticonvulsant plasma level during pregnancy.
Topics: Adult; Anticonvulsants; Antipyrine; Delivery, Obstetric; Dose-Response Relationship, Drug; Epilepsy; | 1982 |
[Inhibition by dipropyl acetate and its structural analogs of the glycine synthase system in liver and brain mitochondria].
Topics: Amino Acid Oxidoreductases; Animals; Anticonvulsants; Brain; Carrier Proteins; Epilepsy; Glycine; Ma | 1982 |
Plasma levels of sodium valproate in childhood epilepsy.
Topics: Adolescent; Age Factors; Body Weight; Child; Child, Preschool; Dose-Response Relationship, Drug; Dru | 1982 |
Sodium valproate: monotherapy and polytherapy.
Topics: Adolescent; Adult; Carbamazepine; Drug Therapy, Combination; Epilepsies, Myoclonic; Epilepsies, Part | 1982 |
[Laboratory parameters in valproate therapy].
Topics: Adolescent; Adult; Blood Coagulation Tests; Child; Child, Preschool; Drug Therapy, Combination; Enzy | 1982 |
Determination of unbound valproic acid concentration in plasma by equilibrium dialysis and gas--liquid chromatography: methodological aspects and observations in epileptic patients.
Topics: Blood Preservation; Blood Proteins; Chromatography, Gas; Dialysis; Epilepsy; Fatty Acids, Nonesterif | 1982 |
Therapeutic concentration of antiepileptic drugs and the severity of epileptogenesis.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Isoxazoles; Phenytoin; Valproic Acid; Zonisamide | 1982 |
The use of the inter-ictal EEG in the study of antiepileptic drugs.
Topics: Adolescent; Adult; Anticonvulsants; Brain; Electroencephalography; Epilepsy; Female; Humans; Light; | 1982 |
Stuporous states or coma induced by the rapid administration of high doses of sodium valproate.
Topics: Adult; Anticonvulsants; Barbiturates; Coma; Drug Therapy, Combination; Electroencephalography; Epile | 1982 |
Comparison of the effectiveness of several formulations of sodium valproate: tablets, enteric-coated capsules, solutions and rectal capsules.
Topics: Adolescent; Adult; Capsules; Child; Child, Preschool; Drug Evaluation; Epilepsy; Humans; Infant; Rec | 1982 |
Quantitative determination of n-dipropylacetamide in the plasma of epileptic patients by gas--liquid chromatography with nitrogen-selective detection.
Topics: Anticonvulsants; Chromatography, Gas; Epilepsy; Humans; Nitrogen; Valproic Acid | 1982 |
[Human teratogenicity of valproic acid containing antiepileptic drugs].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complic | 1982 |
[The effect of anticonvulsive therapy on the psychological achievements in epileptic children].
Topics: Achievement; Adolescent; Carbamazepine; Child; Epilepsy; Female; Humans; Male; Valproic Acid | 1982 |
Effect of valproic acid on hepatic functions.
Topics: Adolescent; Adult; Child; Epilepsy; Female; Follow-Up Studies; Humans; Liver; Liver Function Tests; | 1982 |
A multivariable evoked potential measure applied to human epilepsy.
Topics: Adult; Brain; Epilepsy; Evoked Potentials; Humans; Male; Models, Neurological; Photic Stimulation; V | 1980 |
[A study on cerebrospinal fluid and saliva to serum concentration ratios of anticonvulsants--Phenytoin, Phenobarbital, Valproic Acid and Primidone in epileptic patients].
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsy; Humans; Middle Aged; Phenobar | 1982 |
[Indication of tele-electroencephalography coupled to videoscopy in the study of higher functions in the epileptic child].
Topics: Adolescent; Child; Child, Preschool; Double-Blind Method; Electroencephalography; Epilepsy; Evoked P | 1982 |
[Readjustment of anticonvulsive therapy in children. Monitoring of the effects of sodium valproate after barbiturate withdrawal by electrophysiologic sleep studies].
Topics: Adolescent; Adult; Barbiturates; Child; Electroencephalography; Electromyography; Electrooculography | 1982 |
Sodium valproate: pharmacokinetics and effectivensss in treating intractable seizures.
Topics: Adolescent; Adult; Child; Child, Preschool; Drug Interactions; Epilepsy; Female; Half-Life; Humans; | 1980 |
Valproic acid and plasma levels of phenobarbital.
Topics: Adult; Animals; Cats; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Male; Phenobar | 1980 |
Effect of single doses of sodium valproate on serum phenytoin levels and protein binding in epileptic patients.
Topics: Adult; Blood Proteins; Epilepsy; Humans; Kinetics; Male; Phenytoin; Protein Binding; Valproic Acid | 1980 |
Valproic acid in epilepsy.
Topics: Adolescent; Adult; Child; Child, Preschool; Drug Tolerance; Epilepsy; Humans; Middle Aged; Valproic | 1980 |
Practical considerations in anticonvulsant therapy--Part 2.
Topics: Anticonvulsants; Benzodiazepines; Cost Control; Epilepsy; Ethosuximide; Humans; Monitoring, Physiolo | 1995 |
Erythrocyte antioxidant enzyme activities in children with myelomeningocele.
Topics: Adolescent; Adult; Child; Child, Preschool; Epilepsy; Erythrocytes; Female; Glutathione Peroxidase; | 1995 |
Fetal valproate syndrome: clinical and neuro-developmental features in two sibling pairs.
Topics: Adult; Autistic Disorder; Child, Preschool; Clonazepam; Developmental Disabilities; Epilepsy; Family | 1994 |
Increased fetal hemoglobin production in patients receiving valproic acid for epilepsy.
Topics: Adult; Amides; Arginine; Butyrates; Epilepsy; Fetal Hemoglobin; Humans; Phenylacetates; Phenylbutyra | 1994 |
Negative myoclonus during valproate-related stupor. Neurophysiological evidence of a cortical non-epileptic origin.
Topics: Adult; Age of Onset; Cerebral Cortex; Electroencephalography; Epilepsies, Partial; Epilepsy; Female; | 1995 |
Dose-dependent anticonvulsant and proconvulsant effects of nitric oxide synthase inhibitors on seizure threshold in a cortical stimulation model in rats.
Topics: Amino Acid Oxidoreductases; Analysis of Variance; Animals; Arginine; Cerebral Cortex; Disease Models | 1995 |
Plasma trace element, plasma glutathione peroxidase, and superoxide dismutase levels in epileptic children receiving antiepileptic drug therapy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Erythrocytes; Female; | 1995 |
Neurological deterioration in patients with urea cycle disorders under valproate therapy--a cause for concern.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Ammonia; Arginine; Child; Epilepsy; Female; Humans | 1995 |
Reversible dementia and apparent brain atrophy during valproate therapy.
Topics: Atrophy; Brain Diseases; Child; Child, Preschool; Dementia; Epilepsy; Female; Humans; Magnetic Reson | 1995 |
Stimulation of fetal hemoglobin production by short chain fatty acids.
Topics: Adult; Anemia, Sickle Cell; Animals; Anticonvulsants; Butyrates; Butyric Acid; Cells, Cultured; Epil | 1995 |
Bradycardia, an epileptic ictal manifestation.
Topics: Adult; Anticonvulsants; Bradycardia; Electrocardiography; Electroencephalography; Epilepsy; Epilepsy | 1995 |
Effects of carbamazepine and valproate on brainstem auditory evoked potentials in epileptic children.
Topics: Anticonvulsants; Auditory Pathways; Brain Stem; Carbamazepine; Child; Child, Preschool; Epilepsies, | 1995 |
Valproate-associated pancreatitis and cholecystitis in six mentally retarded adults.
Topics: Adult; Anticonvulsants; Bipolar Disorder; Cholecystitis; Comorbidity; Epilepsy; Humans; Intellectual | 1995 |
Psychotropic medications and their effects on sexual function.
Topics: Bupropion; Epilepsy; Female; Humans; Male; Psychotropic Drugs; Selective Serotonin Reuptake Inhibito | 1995 |
Cytokine production in blood mononuclear cells from epileptic patients.
Topics: Adolescent; Adult; Carbamazepine; Cytokines; Epilepsy; Female; Humans; Interleukin-1; Interleukin-2; | 1995 |
Extracellular magnesium and anticonvulsant effects of valproate in young rat hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Epilepsy; gamma-Aminobutyric Acid; Hippocampu | 1995 |
Valproic acid-carbamazepine interaction: is valproic acid a selective inhibitor of epoxide hydrolase?
Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Drug Interactions; Epilepsy; Epoxide Hydr | 1995 |
Eosinophilic pleural effusion associated with valproic acid administration.
Topics: Adult; Epilepsy; Humans; Male; Pleural Effusion; Pulmonary Eosinophilia; Valproic Acid | 1995 |
Distribution of unsaturated metabolites of valproate in human and rat brain--pharmacologic relevance?
Topics: Adolescent; Adult; Aged; Animals; Biological Transport; Blood-Brain Barrier; Brain; Brain Chemistry; | 1995 |
Effect of carbamazepine and valproate on bone mineral density.
Topics: Absorptiometry, Photon; Adolescent; Bone Density; Calcium, Dietary; Carbamazepine; Case-Control Stud | 1995 |
Anticonvulsant effect of intraventricular antiepileptic drugs. Experimental study.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Epilepsy; Injections, Intraventricul | 1995 |
Predicting unbound phenytoin concentrations in patients receiving valproic acid: a comparison of two prediction methods.
Topics: Adult; Bias; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Middle Aged; Phenytoin; Pred | 1995 |
Determination of urinary valproylcarnitine by gas chromatography-mass spectrometry with selected-ion monitoring.
Topics: Calibration; Carbon Tetrachloride; Carnitine; Dimethylformamide; Drug Stability; Epilepsy; Gas Chrom | 1995 |
Drugs for epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Epilepsy; Humans; Phenytoin | 1995 |
Self-esteem and behavioural adjustment in children with epilepsy and children with diabetes.
Topics: Adolescent; Carbamazepine; Child; Child Behavior Disorders; Cross-Sectional Studies; Diabetes Mellit | 1994 |
Reduced carnitine and antiepileptic drugs: cause relationship or co-existence?
Topics: Adolescent; Anticonvulsants; Carbamazepine; Carnitine; Child; Child, Preschool; Epilepsy; Female; Hu | 1995 |
A possible anti-emetic role for sodium valproate in cytotoxic chemotherapy.
Topics: Antiemetics; Antineoplastic Agents; Drug Resistance; Epilepsy; Humans; Leukemia, Myeloid; Male; Midd | 1995 |
[Sensitive physiologic perceptual tests for ocular side effects of drugs exemplified by various anticonvulsants].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Color Perception; Contrast Sensitivity; Da | 1995 |
Effects of antiepileptic drugs on EEG background activity in children with epilepsy: initial phase of therapy.
Topics: Alpha Rhythm; Anticonvulsants; Carbamazepine; Child; Delta Rhythm; Electroencephalography; Epilepsie | 1995 |
[Changes in drug therapy and in seizure frequency in an institution for epilepsy patients between 1971 and 1986].
Topics: Aged; Aged, 80 and over; Anticonvulsants; Barbiturates; Carbamazepine; Drug Therapy, Combination; Dr | 1994 |
Neurologic factors predict a favorable valproate response in bipolar and schizoaffective disorders.
Topics: Bipolar Disorder; Brain Damage, Chronic; Cohort Studies; Double-Blind Method; Electroencephalography | 1994 |
[Valproate related syndrome of inappropriate secretion of antidiuretic hormone (SIADH)--a case report].
Topics: Aged; Aged, 80 and over; Epilepsy; Humans; Inappropriate ADH Syndrome; Male; Valproic Acid | 1994 |
Valproic acid-induced hyperammonemic encephalopathy: MR appearance.
Topics: Adult; Ammonia; Atrophy; Brain Diseases, Metabolic; Cerebral Cortex; Diagnosis, Differential; Epilep | 1994 |
Neonatal fibrinogen depletion caused by sodium valproate.
Topics: Afibrinogenemia; Epilepsy; Female; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Pregnancy | 1994 |
A comparative study of serum F protein and other liver function tests as an index of hepatocellular damage in epileptic patients.
Topics: Adult; Alkaline Phosphatase; Anticonvulsants; Aspartate Aminotransferases; Carbamazepine; Chemical a | 1994 |
Antiepileptics in the elderly. Pharmacoepidemiology and pharmacokinetics.
Topics: Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy; H | 1994 |
[25 years of valproate in Switzerland].
Topics: Epilepsy; History, 20th Century; Humans; Switzerland; Valproic Acid | 1994 |
[Sodium valproate and cognitive function].
Topics: Adolescent; Adult; Child; Epilepsy; Humans; Mental Processes; Neuropsychological Tests; Valproic Aci | 1994 |
Bone marrow suppression induced by high dose valproic acid.
Topics: Anemia; Bone Marrow; Cells, Cultured; Colony-Forming Units Assay; Depression, Chemical; Epilepsy; Fe | 1994 |
Aplasia cutis congenita of the scalp in an infant exposed to valproic acid in utero.
Topics: Abnormalities, Drug-Induced; Adult; Causality; Epilepsy; Female; Humans; Infant, Newborn; Male; Preg | 1994 |
Changes of thyroid hormone levels in epileptic patients.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Male; Phenytoin; Thyrotropin; Thyro | 1994 |
Epilepsy treatment in The Netherlands. Comparison of matched groups of two medical centres.
Topics: Adolescent; Adult; Carbamazepine; Diazepam; Epilepsy; Ethosuximide; Female; gamma-Aminobutyric Acid; | 1994 |
Impairment of consciousness induced by valproate treatment following neurosurgical operation.
Topics: Adolescent; Adult; Arousal; Brain Neoplasms; Cerebral Hemorrhage; Coma; Consciousness Disorders; Del | 1993 |
The influence of polytherapy on the relationships between serum carbamazepine and its metabolites in epileptic children.
Topics: Aging; Anticonvulsants; Body Weight; Carbamazepine; Child; Chromatography, High Pressure Liquid; Dru | 1994 |
Choreiform movements associated with the use of valproate.
Topics: Adolescent; Adult; Brain Injuries; Child; Chorea; Epilepsy; Female; Humans; Male; Valproic Acid | 1994 |
Antiepileptic drug hypersensitivity syndrome: in vitro and clinical observations.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cross Reactions; Drug Hypersens | 1994 |
A retrospective study of 113 epileptic patients treated with sustained-release valproate.
Topics: Anticonvulsants; Carbamazepine; Delayed-Action Preparations; Drug Administration Schedule; Drug Ther | 1994 |
[The efficacy of depakin in treatment-resistant epilepsy].
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Chronic Disease; Drug Evaluation; Drug | 1993 |
[Anticonvulsant activity of sodium valproate and various calcium antagonists during their combined use in mice].
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Drug Therapy, Combi | 1993 |
Plasma amino acid alterations in idiopathic generalized epilepsy: an investigation in probands and their first-degree relatives.
Topics: Adult; Amino Acids; Aspartic Acid; Epilepsy; Family; Female; Glutamates; Glycine; Humans; Male; Taur | 1994 |
Valproate-mediated disturbances of hemostasis: relationship to dose and plasma concentration.
Topics: Adult; Bleeding Time; Epilepsy; Female; Hemostasis; Humans; In Vitro Techniques; Male; Platelet Aggr | 1994 |
[Hepatotoxicity induced by valproic acid in adults. Report of 3 cases].
Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Epilepsy; Female; Humans; Male; Valproic | 1993 |
Autism: electroencephalogram abnormalities and clinical improvement with valproic acid.
Topics: Autistic Disorder; Brain; Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Humans; | 1994 |
Pharmacodynamic interactions between phenytoin and valproate: individual and combined antiepileptic and neurotoxic actions in mice.
Topics: Animals; Brain; Brain Diseases; Drug Interactions; Drug Synergism; Electroshock; Epilepsy; Female; M | 1994 |
Pregnancy, epilepsy, management and outcome: a 10-year perspective.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Birth Weight; Carbamazepine; Cohort Studies; Drug Ther | 1993 |
[Valproic acid: a simple method for the estimation of free serum concentration].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Albumins; Epilepsy; Female; Humans; Male; Middle Aged; V | 1993 |
Psoriasiform eruption induced by anticonvulsants.
Topics: Adult; Carbamazepine; Drug Eruptions; Epilepsy; Female; Humans; Male; Middle Aged; Psoriasis; Valpro | 1994 |
Analysis of the transport of valproic acid into saliva from serum.
Topics: Adolescent; Adult; Aged; Child; Diffusion; Epilepsy; Female; Humans; Male; Mathematics; Microvilli; | 1994 |
Malformations, withdrawal manifestations, and hypoglycaemia after exposure to valproate in utero.
Topics: Drug Administration Schedule; Epilepsy; Female; Heart Defects, Congenital; Humans; Infant, Newborn; | 1993 |
The use of antiepileptic drug levels in children: a survey of Canadian pediatric neurologists.
Topics: Adolescent; Anticonvulsants; Attitude of Health Personnel; Carbamazepine; Child; Epilepsy; Ethosuxim | 1993 |
The rapid change to monotherapy with valproic acid in children.
Topics: Adolescent; Anticonvulsants; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Epilep | 1993 |
Ammonia-independent modifications of the background EEG signal and paradoxical enhancement of epileptic abnormalities in EEG after acute administration of valproate to epileptic patients.
Topics: Adolescent; Adult; Ammonia; Arousal; Blood Glucose; Blood Pressure; Electroencephalography; Epilepsy | 1993 |
Impaired fatty acid oxidation in children on valproic acid and the effect of L-carnitine.
Topics: Adolescent; Adult; Breath Tests; Carnitine; Child; Child, Preschool; Chromatography, High Pressure L | 1993 |
Valproate and palmitate binding to serum albumin in valproate-treated patients. Relation to obesity.
Topics: Adult; Body Mass Index; Epilepsy; Fatty Acids, Nonesterified; Female; Humans; Male; Middle Aged; Mod | 1993 |
Nutritional factors and anticonvulsant therapies: effect on growth in children with epilepsy.
Topics: Carbamazepine; Child; Child Nutritional Physiological Phenomena; Child, Preschool; Cross-Sectional S | 1993 |
Relationship of carnitine and carnitine precursors lysine, epsilon-N-trimethyllysine, and gamma-butyrobetaine in drug-induced carnitine depletion.
Topics: Adolescent; Bacteriuria; Betaine; Carnitine; Child; Child, Preschool; Creatinine; Epilepsy; Female; | 1993 |
Changes in red blood cells with valproate therapy.
Topics: Anemia, Macrocytic; Blood Platelets; Epilepsy; Erythrocyte Indices; Erythrocyte Volume; Erythrocytes | 1993 |
Valproate retard granule: efficacy and side effects.
Topics: Adolescent; Child; Child, Preschool; Delayed-Action Preparations; Dose-Response Relationship, Drug; | 1993 |
Teratogenicity of antiepileptic drugs and drug specific malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug | 1993 |
[Three cases of hypofibrinogenemia induced by chemotherapy with a combination of synthetic ACTH and valproic acid].
Topics: Adrenocorticotropic Hormone; Afibrinogenemia; Child, Preschool; Drug Therapy, Combination; Epilepsy; | 1994 |
Vitamins to prevent neural-tube defects.
Topics: Epilepsy; Female; Humans; Neural Tube Defects; Pantothenic Acid; Pregnancy; Pregnancy Complications; | 1993 |
Magnetic stimulation of the brain in generalized epilepsy: reversal of cortical hyperexcitability by anticonvulsants.
Topics: Adolescent; Adult; Analysis of Variance; Brain; Child; Epilepsy; Female; Humans; Magnetics; Male; Mi | 1993 |
Treating epilepsy--when, with what and by whom?
Topics: Adult; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complications; Seizures; Valproic Acid | 1993 |
[Acute reversible liver necrosis after valproate therapy (immunologic hypersensitivity)].
Topics: Child; Drug Hypersensitivity; Epilepsy; Humans; Liver; Liver Cirrhosis; Male; Necrosis; Transaminase | 1993 |
Five years of anticonvulsant monitoring on site at the epilepsy clinic.
Topics: Anticonvulsants; Carbamazepine; Drug Monitoring; Epilepsy; Humans; Outpatient Clinics, Hospital; Phe | 1993 |
An audit of therapeutic drug monitoring of anticonvulsants.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Drug Monitoring; Epilepsy; Humans; Medical Audit; Nort | 1995 |
Fetal valproate syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Epilepsy; Face; Female; Human | 1995 |
A model for estimating individualized valproate clearance values in children.
Topics: Administration, Oral; Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Ther | 1995 |
Pharmacology of cortical epileptic afterdischarges in rats.
Topics: Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Dimethyl Sulfoxide; Disease Models, Animal | 1996 |
Valproic acid hepatic fatalities. III. U.S. experience since 1986.
Topics: Adolescent; Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; | 1996 |
Obesity and endocrine disorders in women taking valproate for epilepsy.
Topics: Adult; Body Weight; Carbamazepine; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Endocrine | 1996 |
Effect of valproate on cerebral metabolism and blood flow: an 18F-2-deoxyglucose and 15O water positron emission tomography study.
Topics: Adult; Brain; Carbamazepine; Cerebrovascular Circulation; Deoxyglucose; Dose-Response Relationship, | 1996 |
Valproate-induced systemic lupus erythematosus in a patient with partial trisomy of chromosome 9 and epilepsy.
Topics: Adult; Chromosomes, Human, Pair 9; Comorbidity; Epilepsy; Female; HLA-DR4 Antigen; Humans; Intellect | 1996 |
Weight loss in patients taking felbamate.
Topics: Adolescent; Adult; Anticonvulsants; Body Weight; Child; Epilepsy; Felbamate; Humans; Middle Aged; Ph | 1995 |
[Study of the influence of anticonvulsant treatment on thyroid function].
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Enzyme-Linked Immunosorbent Assay; E | 1995 |
Effect of L-carnitine supplementation on acute valproate intoxication.
Topics: Ammonia; Carnitine; Coma; Drug Overdose; Epilepsy; Humans; Infant; Male; Oxidation-Reduction; Valpro | 1996 |
Catamenial epilepsy: gynecological and hormonal implications. Five case reports.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Estradiol; Female; Humans; Premenstrual | 1996 |
Valproate induced encephalopathy treated with carnitine in an adult.
Topics: Adult; Anticonvulsants; Carnitine; Epilepsy; Female; Hepatic Encephalopathy; Humans; Liver; Valproic | 1996 |
[Subependymal nodular heterotopia and epilepsy].
Topics: Age of Onset; Anticonvulsants; Brain; Choristoma; Epilepsy; Female; Humans; Middle Aged; Pedigree; P | 1996 |
Pharmacokinetics of slow-release preparations of sodium valproate.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Delayed-Action Preparations; Dose-Respo | 1995 |
Comparing antiepileptic drugs.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Phenobarbital; Valproic Acid | 1996 |
Clearance of phenytoin and valproic acid is affected by a small body weight reduction in an epileptic obese patient: a case study.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Half-Life; Humans; Metabolic Clearance Rate | 1996 |
[The effects of phenobarbital, valproic acid and carbamazepine on the serum lipids and lipoproteins in a pediatric population].
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Infan | 1996 |
Fluctuations of 10-hydroxy-carbazepine during the day in epileptic patients.
Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Huma | 1996 |
The effects of antiepileptic drugs on serum zinc and copper levels in children.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Copper; Drug Therapy, Combination; Epilepsy | 1995 |
Radiological case of the month. In utero ultrasonographic demonstration of a lymphangioma.
Topics: Adult; Epilepsy; Female; Fetal Diseases; Humans; Infant, Newborn; Liver Neoplasms; Lymphangioma, Cys | 1996 |
The necessity of adjusting the dosage of zonisamide when coadministered with other anti-epileptic drugs.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combinatio | 1996 |
Detection of carbamazepine drug interaction by multiple peak approach screening using routine clinical pharmacokinetic data.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Interactions; | 1996 |
Volvular epilepsy associated with line-of-migration abnormality: a case report.
Topics: Anticonvulsants; Cell Movement; Child; Electroencephalography; Epilepsy; Female; Frontal Lobe; Human | 1996 |
Metabolite profiles in patients on high-dose valproate monotherapy.
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Liver; Male; Valproic Acid | 1996 |
Salivary protein composition in epileptic patients on different medications.
Topics: Adult; Aged; Albumins; Amylases; Anticonvulsants; Carbamazepine; Cystatin C; Cystatins; Cysteine Pro | 1996 |
Plasma tryptophan levels in children with epilepsy before and after antiepileptic treatment.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Humans; Male; Tryptophan; Valpr | 1996 |
The platelet aggregation in children with epilepsy receiving valproic acid.
Topics: Adolescent; Anticonvulsants; Blood Coagulation Tests; Child; Child, Preschool; Epilepsy; Female; Hum | 1996 |
New antiepileptic drugs: from discovery to practical use. Clinical directions for the future. Proceedings of the 3rd International Merritt-Putnam Symposium. Sydney, Australia, September 6, 1995.
Topics: Anticonvulsants; Epilepsy; Humans; Valproic Acid | 1996 |
[Embryofetopathy due to valproate: a pathology only little known. Apropos of 4 cases].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child, Preschool; Cleft Lip; Epilepsy; Face; Female; F | 1996 |
Comparison of two binding equations for prediction of the concentration of unbound valproic acid in the serum of adult epileptic polytherapy patients.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Blood Proteins; Epilepsy; Female; Humans; Male; Middle Age | 1996 |
Valproate metabolites in high-dose valproate plus phenytoin therapy.
Topics: Adolescent; Alanine Transaminase; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injur | 1996 |
Suppression of cortical epileptic afterdischarges in developing rats by anticonvulsants increasing GABAergic inhibition.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Depression, Chemical; Drug Evaluation, Preclinical; Elect | 1996 |
Effects of various valproic acid derivatives on low-calcium spontaneous epileptiform activity in hippocampal slices.
Topics: Animals; Anticonvulsants; Calcium; Carbohydrates; Electroshock; Epilepsy; Hippocampus; In Vitro Tech | 1995 |
Reduction in blood free carnitine levels in association with changes in sodium valproate (VPA) disposition in epileptic patients treated with VPA and other anti-epileptic drugs.
Topics: Adult; Aged; Anticonvulsants; Carnitine; Epilepsy; Female; Humans; Male; Middle Aged; Valproic Acid | 1997 |
Effect of topiramate on the pharmacokinetics of an oral contraceptive containing norethindrone and ethinyl estradiol in patients with epilepsy.
Topics: Adult; Anticonvulsants; Contraception; Contraceptives, Oral, Combined; Contraceptives, Oral, Synthet | 1997 |
Mechanism for reduction of serum folate by antiepileptic drugs during prolonged therapy.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Demography; Epilepsy; Fe | 1997 |
Clinical pharmacokinetics of carbamazepine and valproate in children and adolescents with epilepsy.
Topics: Adolescent; Antidepressive Agents; Brain; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; | 1996 |
Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1997 |
Fetal valproate embryopathy in twins: genetic modification of the response to a teratogen.
Topics: Abnormalities, Multiple; Adult; Anticonvulsants; Diseases in Twins; Epilepsy; Female; Humans; Infant | 1996 |
Interactions of clobazam with conventional antiepileptics in children.
Topics: Adolescent; Age Factors; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; C | 1997 |
Color vision tests for early detection of antiepileptic drug toxicity.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Color Perception; Epilepsy; Humans; Osmolar Conce | 1997 |
[Sturge-Weber syndrome: experience with 14 cases].
Topics: Anticonvulsants; Brain; Carbamazepine; Epilepsy; Female; Humans; Infant; Magnetic Resonance Imaging; | 1997 |
Topiramate for epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Int | 1997 |
Differential effect of carbamazepine and valproate monotherapy on plasma levels of oestrone sulphate and dehydroepiandrosterone sulphate in male epileptic patients.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Dehydroepiandrosterone; Dehydroepiandrosterone Su | 1997 |
Effects of valproate, phenytoin, and MK-801 in a novel model of epileptogenesis.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain Stem; Disease Models, Animal; Dizocilpine Maleate; | 1997 |
Persistence of photosensitivity.
Topics: Adolescent; Adult; Age Factors; Age of Onset; Anticonvulsants; Electroencephalography; Epilepsy; Fam | 1997 |
[Acute hepatic failure associated with valproic acid in children. Report of 3 cases].
Topics: Anticonvulsants; Child, Preschool; Epilepsy; Female; Humans; Liver Failure, Acute; Male; Risk Factor | 1996 |
Thrombocytopenic purpura and anemia in a breast-fed infant whose mother was treated with valproic acid.
Topics: Anemia; Anticonvulsants; Breast Feeding; Epilepsy; Female; Humans; Infant; Infant, Newborn; Maternal | 1997 |
[Current knowledge on epilepsy, schizophrenia and spastic conditions. Neuro-Forum, Dresden, 5 April 1997].
Topics: Anticonvulsants; Carbamazepine; Chronic Disease; Epilepsies, Partial; Epilepsy; Humans; Remission In | 1997 |
[Current knowledge on epilepsy, schizophrenia and spastic conditions. Neuro-Forum, Dresden, 5 April 1997].
Topics: Anticonvulsants; Carbamazepine; Chronic Disease; Epilepsies, Partial; Epilepsy; Humans; Remission In | 1997 |
The effects of long-term anticonvulsive treatment on serum lipid profile.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Fluorescence | 1997 |
Serum lipids in epileptic children treated with carbamazepine and valproate.
Topics: Adolescent; Analysis of Variance; Anticonvulsants; Apolipoproteins; Carbamazepine; Case-Control Stud | 1997 |
Absence of bleeding complications in patients undergoing cortical surgery while receiving valproate treatment.
Topics: Adult; Cerebral Cortex; Epilepsy; Female; Hemorrhage; Humans; Male; Prognosis; Retrospective Studies | 1997 |
AWD 140-190: a new anticonvulsant with a very good margin of safety.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; E | 1997 |
Diet- and valproate-induced transient hyperammonemia: effect of L-carnitine.
Topics: Administration, Oral; Adolescent; Ammonia; Anticonvulsants; Carnitine; Child; Diet; Epilepsy; Female | 1997 |
Changes in serum lipids and lipoproteins in epileptic children treated with anticonvulsants.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Humans; Hyperlipidemias; Lipids | 1997 |
Auditory event related potentials in patients with epilepsy on sodium valproate monotherapy.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Evoked Potentials, Auditory; Female; Humans; Male; | 1997 |
Clinical and economic impact of replacing divalproex sodium with valproic acid.
Topics: Adult; Anticonvulsants; Costs and Cost Analysis; Epilepsy; Female; Hospitals, Psychiatric; Humans; I | 1997 |
[Evaluation of the effect of long term valproic acid treatment on plasma levels of carnitine, ammonia and amino acids related to the urea cycle in pediatric epileptic patients].
Topics: Adolescent; Amino Acids; Ammonia; Anticonvulsants; Carnitine; Child; Child, Preschool; Epilepsy; Glu | 1997 |
[The effect of enkorat on the course of epilepsy in children].
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Evaluation; Epilepsy; Female; Humans; Mal | 1996 |
Asymptomatic hyperammonemia in children treated with valproic acid.
Topics: Adolescent; Adult; Ammonia; Anticonvulsants; Carnitine; Child; Child, Preschool; Epilepsy; Female; H | 1997 |
Detection of carbamazepine-induced changes in valproic acid relative clearance in man by simple pharmacokinetic screening.
Topics: Adolescent; Adult; Aging; Anticonvulsants; Body Weight; Carbamazepine; Child; Child, Preschool; Drug | 1997 |
Menstrual cycle and ovary alterations in women with epilepsy on antiepileptic therapy.
Topics: Adolescent; Adult; Anovulation; Anticonvulsants; Corpus Luteum; Epilepsy; Female; Humans; Menstruati | 1997 |
Polycystic ovary syndrome associated with treatment with the anticonvulsant sodium valproate.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Polycystic Ovary Syndrome; Pregnancy; Valproic Aci | 1997 |
Oxcarbazepine in the treatment of early childhood epilepsy.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Resistance; Drug Therapy, Combination; | 1997 |
[Lamotrigine (Lamictal)].
Topics: Anticonvulsants; Brain; Child; Child, Preschool; Drug Combinations; Drug Eruptions; Epilepsies, Part | 1997 |
Hyponatremia due to sodium valproate.
Topics: Anticonvulsants; Epilepsy; Humans; Hyponatremia; Male; Middle Aged; Valproic Acid | 1998 |
Population-based investigation of valproic acid relative clearance using nonlinear mixed effects modeling: influence of drug-drug interaction and patient characteristics.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Interactions; Epile | 1997 |
Studies of drugs in epilepsy cited by author are not evidence based.
Topics: Anticonvulsants; Carbamazepine; Drug Combinations; Epilepsy; Evidence-Based Medicine; GABA Agents; g | 1998 |
[Experts take a position: Valproate--standard therapy in all forms of epilepsy].
Topics: Anticonvulsants; Epilepsy; Humans; Valproic Acid | 1996 |
Treatment of the epileptic patient in the dental office.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Child; Dental Care for Chronically Ill; Emergencies; Ep | 1998 |
To what extent do premenstrual and interictal dysphoric disorder overlap? Significance for therapy.
Topics: Adult; Anticonvulsants; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepress | 1998 |
Valproate, lamotrigine, and insulin-mediated risks in women with epilepsy.
Topics: Analysis of Variance; Anticonvulsants; Cholesterol, HDL; Epilepsy; Female; Follow-Up Studies; Humans | 1998 |
Side effect of ibuprofen and valproic acid.
Topics: Adolescent; Ankle Injuries; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Drug Interacti | 1998 |
Urinary metabolites of valproic acid in epileptic patients.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Epilepsy; Female; Gas Chromatography-Mass Spectrometry; Hu | 1998 |
Valproate therapy does not deplete carnitine levels in otherwise healthy children.
Topics: Adolescent; Adult; Ammonia; Carnitine; Case-Control Studies; Child; Epilepsy; Female; Humans; Male; | 1998 |
[Acquired aphasic epilepsy (Landau-Kleffner syndrome). Report of 10 cases].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Aphasia; Brain; Carbamazepine; Child; Child, Preschool | 1997 |
Reversible pseudoatrophy of the brain and mental deterioration associated with valproate treatment.
Topics: Atrophy; Brain; Brain Diseases; Child; Cognition Disorders; Diagnosis, Differential; Electroencephal | 1998 |
Interictal cardiovascular autonomic responses in patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Autonomic Nervous System; Blood Pressure; Epilepsy; Female; Hear | 1998 |
Comparison of effects of valproate and trans-2-en-valproate on different forms of epileptiform activity in rat hippocampal and temporal cortex slices.
Topics: Action Potentials; Animals; Anticonvulsants; Electroencephalography; Entorhinal Cortex; Epilepsy; Ex | 1998 |
Teratogenic effects of antiepileptic drugs: what do we advise patients?
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Patient Advoc | 1997 |
Migraine with visual aura and photosensitive epileptic seizures.
Topics: Adult; Comorbidity; Cortical Spreading Depression; Dopamine; Electroencephalography; Epilepsy; Human | 1997 |
Detection of a drug-drug interaction on population-based phenobarbitone clearance using nonlinear mixed-effects modeling.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Body Weight; Carbamazepine; Child; Child, Preschool | 1998 |
Veratridine-treated brain slices: a cellular model for epileptiform activity.
Topics: Action Potentials; Animals; Anticonvulsants; Brain; Electrophysiology; Epilepsy; In Vitro Techniques | 1998 |
Does antiepileptic therapy affect immune response?
Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbama | 1998 |
Replacement of divalproex sodium with valproic acid not clear-cut.
Topics: Anticonvulsants; Epilepsy; Humans; Valproic Acid | 1998 |
Complications of the ketogenic diet.
Topics: Adolescent; Carnitine; Child; Child, Preschool; Combined Modality Therapy; Epilepsy; Follow-Up Studi | 1998 |
[Prenatal ultrasonographic diagnosis in the epileptic mother on valproic acid. Retrospective study of 161 cases in the central eastern France register of congenital malformations].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; France; Humans; Population Surveilla | 1998 |
Panipenem-betamipron and decreases in serum valproic acid concentration.
Topics: Adult; Anticonvulsants; beta-Alanine; Child, Preschool; Drug Interactions; Drug Therapy, Combination | 1998 |
Peripheral benzodiazepine receptor expression on leukocytes and neutrophil function during anticonvulsant monotherapy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Leukocytes; Lymph | 1998 |
Reading epilepsy: report of five new cases and further considerations on the pathophysiology.
Topics: Adolescent; Adult; Anticonvulsants; Electroencephalography; Epilepsy; Female; Humans; Kindling, Neur | 1998 |
Antiepileptic drug treatment of West syndrome.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Child; Drug Administration Schedule; Drug Therapy, Com | 1998 |
Evaluation of bone mineral density in children receiving antiepileptic drugs.
Topics: Absorptiometry, Photon; Alkaline Phosphatase; Anticonvulsants; Bone Density; Calcium; Carbamazepine; | 1998 |
Valproate therapy: predisposition to bone fracture?
Topics: Adolescent; Bone and Bones; Disease Susceptibility; Epilepsy; Female; Femoral Fractures; Foot; Fract | 1998 |
Valproate selectively reduces the persistent fraction of Na+ current in neocortical neurons.
Topics: Animals; Anticonvulsants; Cells, Cultured; Epilepsy; Humans; In Vitro Techniques; Membrane Potential | 1998 |
Valproate and carbamazepine comedication changes hepatic enzyme activities in sera of epileptic children.
Topics: Adolescent; Alanine Transaminase; Anticonvulsants; Aspartate Aminotransferases; Carbamazepine; Catal | 1998 |
Changes of the EEG paroxysmal pattern during felbamate therapy in Lennox-Gastaut syndrome: a case report.
Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Clobazam; Drug Therapy, | 1998 |
Valproate and polycystic ovaries.
Topics: Adolescent; Adult; Anticonvulsants; Child; Epilepsy; Female; Humans; Hyperandrogenism; Polycystic Ov | 1998 |
Quantifying the costs of serious adverse drug reactions to antiepileptic drugs.
Topics: Adolescent; Adult; Anticonvulsants; Direct Service Costs; Drug Costs; Drug Hypersensitivity; Epileps | 1998 |
L-carnitine supplementation in childhood epilepsy: current perspectives.
Topics: Age Factors; Ammonia; Anticonvulsants; Carnitine; Chemical and Drug Induced Liver Injury; Child; Chi | 1998 |
Effects of new valproate derivatives on epileptiform discharges induced by pentylenetetrazole or low Mg2+ in rat entorhinal cortex-hippocampus slices.
Topics: Animals; Anticonvulsants; Convulsants; Entorhinal Cortex; Epilepsy; Female; Glucose; Hippocampus; In | 1998 |
[Serum lipids. lipoproteins, and apolipoproteins in adult epileptics treated with carbamazepine, valproic acid, or phenytoin].
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Apolipoproteins; Carbamazepine; Cholesterol; Choles | 1998 |
Lamotrigine and therapeutic drug monitoring: retrospective survey following the introduction of a routine service.
Topics: Anticonvulsants; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Epilepsy; Health Car | 1998 |
Serum lipids and lipoproteins in patients treated with antiepileptic drugs.
Topics: Adolescent; Adult; Anticonvulsants; Apolipoprotein A-I; Apolipoproteins B; Carbamazepine; Cholestero | 1998 |
Influence of valproate monotherapy on platelet activation and hematologic values.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Flow Cytometry; Fluorescent Antibody Technique; Hematologi | 1999 |
N-acetyl-beta-glucosaminidase and beta-galactosidase activity in children receiving antiepileptic drugs.
Topics: Acetylglucosaminidase; Anticonvulsants; beta-Galactosidase; Biomarkers; Carbamazepine; Case-Control | 1999 |
The effects of valproate, carbamazepine, and oxcarbazepine on growth and sexual maturation in girls with epilepsy.
Topics: Adolescent; Anthropometry; Anticonvulsants; Carbamazepine; Child; Cross-Sectional Studies; Epilepsy; | 1999 |
[Encephalopathies caused by valproate].
Topics: Adult; Ammonia; Anticonvulsants; Brain Diseases; Drug Interactions; Epilepsy; Humans; Middle Aged; V | 1999 |
Valproate treatment and platelet function: the role of arachidonate metabolites.
Topics: Adult; Arachidonic Acids; Blood Coagulation Tests; Blood Platelets; Epilepsy; Fasting; Hemorrhagic D | 1999 |
Elevated plasma concentrations of homocysteine in antiepileptic drug treatment.
Topics: Age Factors; Ambulatory Care; Anticonvulsants; Carbamazepine; Convulsants; Depression, Chemical; Epi | 1999 |
More on valproate and polycystic ovaries.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Humans; Obesity; Polycystic Ovary Syndrome; Va | 1999 |
Valproate-induced hyperandrogenism during pubertal maturation in girls with epilepsy.
Topics: Adolescent; Child; Epilepsy; Female; Humans; Hyperandrogenism; Insulin; Insulin-Like Growth Factor B | 1999 |
Intractable epilepsy.
Topics: Abdominal Pain; Anticonvulsants; Carnitine; Child, Preschool; Epilepsy; Humans; Male; Valproic Acid | 1999 |
Characterization of seizures in the flathead rat: a new genetic model of epilepsy in early postnatal development.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Cerebral Cortex; Disease Models, Animal; Electroe | 1999 |
Valproate-induced biochemical abnormalities in pregnancy corrected by vitamins: a case report.
Topics: Adult; Anticonvulsants; Epilepsy; Ethosuximide; Female; Humans; Metabolic Diseases; Pantothenic Acid | 1999 |
Male infertility: possible association with valproate exposure.
Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Felbamate; Female; Humans; Infertility, | 1999 |
Valproate population pharmacokinetics in children.
Topics: Adolescent; Anticonvulsants; Biological Availability; Child; Child, Preschool; Drug Administration S | 1999 |
Carnitine deficiency and hyperammonemia in children receiving valproic acid with and without other anticonvulsant drugs.
Topics: Adolescent; Adult; Ammonia; Anticonvulsants; Carnitine; Child; Child, Preschool; Epilepsy; Female; H | 1999 |
Safety of rapid intravenous infusion of valproate loading doses in epilepsy patients.
Topics: Adolescent; Adult; Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Humans; Infusi | 1999 |
Safe use of valproic acid during pregnancy.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Neural Tube Defects; Pregnancy; Pregnancy Complica | 1999 |
Fatal liver failure associated with valproate therapy in a patient with Friedreich's disease: review of valproate hepatotoxicity in adults.
Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Comorbidity; Epilepsy; Fatal Outcome; Fem | 1999 |
Serum leptin changes in epileptic patients who gain weight after therapy with valproic acid.
Topics: Adolescent; Androgens; Anticonvulsants; Blood Glucose; Body Mass Index; Epilepsy; Female; Follicle S | 1999 |
[Parenteral valproate optimizes emergency- and substitution therapy].
Topics: Emergencies; Epilepsy; First Aid; Humans; Injections; Valproic Acid | 1999 |
Valproic acid elimination rate and urinary excretion of its glucuronide conjugate in patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Glucuronates; Humans; Kidney; Metabolic Clearance Rate | 1999 |
Risk of excessive weight gain in epileptic children treated with valproate.
Topics: Adolescent; Adult; Anticonvulsants; Body Mass Index; Child; Child, Preschool; Dose-Response Relation | 1999 |
Malformations in offspring of women with epilepsy: a prospective study.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Comorbidity; Congenital Abnormalities; | 1999 |
Photo Quiz.
Topics: Aged; Anticonvulsants; Drug Interactions; Epilepsy; Female; Humans; Lamotrigine; Skin; Stevens-Johns | 1999 |
Stevens-Johnson syndrome and antiepileptics.
Topics: Adult; Anticonvulsants; Child; Drug Therapy, Combination; Epilepsy; Humans; Lamotrigine; Stevens-Joh | 1999 |
Migraine polypharmacy and the tolerability of sumatriptan: a large-scale, prospective study.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Anti-As | 1999 |
Clinical experience with new antiepileptic drugs: antiepileptic drugs in Europe.
Topics: Anticonvulsants; Carbamazepine; Clinical Trials as Topic; Cross-Cultural Comparison; Drug Approval; | 1999 |
Factors influencing the incidence of lamotrigine-related skin rash.
Topics: Adolescent; Adult; Anticonvulsants; Child; Dose-Response Relationship, Drug; Drug Therapy, Combinati | 1999 |
[Rett's syndrome: pathophysiology and anesthesiological implications].
Topics: Adult; Anesthesia; Anticonvulsants; Blood Coagulation Disorders; Epilepsy; Female; Humans; Kidney Ca | 1999 |
[Recurrence of herpes simplex encephalitis].
Topics: Acyclovir; Anti-Anxiety Agents; Anti-Inflammatory Agents; Anticonvulsants; Antiviral Agents; Benzodi | 1999 |
Modulation of sodium currents in rat CA1 neurons by carbamazepine and valproate after kindling epileptogenesis.
Topics: Animals; Anticonvulsants; Carbamazepine; Epilepsy; Hippocampus; Kindling, Neurologic; Male; Neurons; | 1999 |
Valproate-induced hyperandrogenism during pubertal maturation in girls with epilepsy.
Topics: Adolescent; Epilepsy; Female; Humans; Hyperandrogenism; Puberty; Sexual Maturation; Valproic Acid | 1999 |
The effect of carbamazepine and sodium valproate on the blood and serum values of children from a third-world environment.
Topics: Adolescent; Anemia; Anticonvulsants; Black People; Carbamazepine; Child; Child, Preschool; Developin | 1999 |
Long-term treatment of children with epilepsy with valproate or carbamazepine may cause subclinical hypothyroidism.
Topics: Adolescent; Age Factors; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Hypothyro | 1999 |
Valproic acid intensifies epileptiform activity in the hippocampal pyramidal neurons.
Topics: Action Potentials; Animals; Bicuculline; Disease Models, Animal; Epilepsy; GABA Antagonists; Hippoca | 1999 |
Valproate-induced hyperammonemic encephalopathy in the presence of topiramate.
Topics: Adult; Ammonia; Anticonvulsants; Brain Diseases; Drug Therapy, Combination; Electroencephalography; | 2000 |
Postoperative anticonvulsant prophylaxis for patients treated for cerebral aneurysms.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Craniotomy; Drug Administration Schedule; Epilepsy; | 1999 |
[A case report of valproate encephalopathy].
Topics: Adult; Ammonia; Anticonvulsants; Biomarkers; Brain; Brain Diseases; Carnitine; Epilepsy; Female; Hum | 1999 |
Orthotopic liver transplantation with poor neurologic outcome in valproate-associated liver failure: a need for critical risk-benefit appraisal in the use of valproate.
Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Fatal Outcome; Female; Humans; Infant; Liver Fai | 2000 |
Valproic acid dosing recommendations questioned.
Topics: Adult; Age Factors; Anticonvulsants; Drug Combinations; Drug Interactions; Epilepsy; Half-Life; Huma | 2000 |
Adverse response to methylphenidate in combination with valproic acid.
Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Bruxism; Central Nervous System Stim | 2000 |
Valproate for girls with epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Epilepsy; Female; Humans; Valproic Acid | 2000 |
[Therapeutic antiepileptic drug monitoring: thirteen years of experience in the Laboratory of Clinical Neuropharmacology in the Chair and Department of Developmental neurology].
Topics: Academic Medical Centers; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy | 2000 |
[Bimodal evoked potentials during long-term therapy with conventional or slow release preparations of carbamazepine and valproic acid in children and adolescents with epilepsy].
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Evoked Potentials; Evoked Potentials, A | 2000 |
[Effectiveness and tolerance of adjunctive treatment of lamotrigine and conversion to monotherapy in pediatric patients with epilepsy. Preliminary studies].
Topics: Adolescent; Adult; Anticonvulsants; Child; Drug Tolerance; Electroencephalography; Epilepsy; Female; | 2000 |
Homocysteine concentrations and methionine loading in patients on antiepileptic drugs.
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Case-Control Studies; Cytochrome P-450 Enzyme System; E | 2000 |
[Drug resistant epilepsy in Senegal: therapeutic, clinical and socioeconomic factors].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Resistance; Epilepsy; Female; Humans; | 1999 |
Repeated acute testing of anticonvulsant drugs in amygdala kindled rats: increase in anticonvulsant but decrease in adverse effect potential.
Topics: Amygdala; Animals; Anticonvulsants; Ataxia; Behavior, Animal; Carbamazepine; Disease Models, Animal; | 2000 |
Appropriate clinical management of women taking valproate.
Topics: Adult; Age Factors; Anticonvulsants; Body Weight; Epilepsy; Female; Humans; Hyperandrogenism; Insuli | 2000 |
Gas chromatography/negative ion chemical ionization mass spectrometry and liquid chromatography/electrospray ionization tandem mass spectrometry quantitative profiling of N-acetylcysteine conjugates of valproic acid in urine: application in drug metabolis
Topics: Acetylcysteine; Adolescent; Analysis of Variance; Animals; Anticonvulsants; Child; Child, Preschool; | 2000 |
N(6)-2-(4-aminophenyl)ethyl-adenosine enhances the anticonvulsive action of conventional antiepileptic drugs in the kindling model of epilepsy in rats.
Topics: Adenosine; Amygdala; Animals; Anticonvulsants; Avoidance Learning; Carbamazepine; Disease Models, An | 2000 |
A clinical study of 57 children with fetal anticonvulsant syndromes.
Topics: Abnormalities, Drug-Induced; Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Ep | 2000 |
Valproate, hyperandrogenism, and polycystic ovaries: a report of 3 cases.
Topics: Adolescent; Adult; Anticonvulsants; Body Weight; Electroencephalography; Epilepsy; Female; Humans; H | 2000 |
Sleep and epilepsy: A key role for nitric oxide?
Topics: Animals; Anticonvulsants; Brain; Cerebral Cortex; Circadian Rhythm; Disease Models, Animal; Electroe | 2000 |
[Antiepileptic drugs and carnitine].
Topics: Adolescent; Anticonvulsants; Carnitine; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; M | 2000 |
Prognosis of seizures occurring in the first year.
Topics: Anticonvulsants; Brain; Child, Preschool; Developmental Disabilities; Diagnosis, Differential; Elect | 2000 |
The effects on lipid and apolipoprotein serum levels of long-term carbamazepine, valproic acid and phenobarbital therapy in children with epilepsy.
Topics: Anticonvulsants; Apolipoprotein A-I; Apolipoproteins; Apolipoproteins B; Carbamazepine; Child; Chole | 2000 |
Liver transplantation: to do or not to do?
Topics: Anticonvulsants; Child; Contraindications; Diffuse Cerebral Sclerosis of Schilder; Epilepsy; Female; | 2000 |
Fatal deterioration of neurological disease after orthotopic liver transplantation for valproic acid-induced liver damage.
Topics: Adolescent; Anticonvulsants; Diffuse Cerebral Sclerosis of Schilder; Electroencephalography; Epileps | 2000 |
[A case with symptomatic epilepsy and mirror movement due to unilateral schizencephaly].
Topics: Anticonvulsants; Brain; Epilepsy; Functional Laterality; Humans; Male; Middle Aged; Movement Disorde | 2000 |
Pathomorphological changes in mouse liver and kidney during prolonged valproate administration.
Topics: Animals; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Epilepsy; Kidney; Kid | 2000 |
Polycystic ovary syndrome in patients with focal epilepsy: a study in 93 women.
Topics: Adult; Amenorrhea; Anticonvulsants; Carbamazepine; Cohort Studies; Drug Therapy, Combination; Epilep | 2000 |
Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Enzyme Inhibitors; Epilepsy | 2000 |
Decrease of valproic acid concentration in the blood when coprescribed with fluoxetine.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Antidepressive Agents, Second-Generation; Depressive Disor | 1997 |
Neonatal hypoglycaemia and withdrawal symptoms after exposure in utero to valproate.
Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Hypoglycemia; I | 2000 |
Molecular regulation of glutamate and GABA transporter proteins by valproic acid in rat hippocampus during epileptogenesis.
Topics: Amino Acid Transport System X-AG; Animals; Anticonvulsants; ATP-Binding Cassette Transporters; Carri | 2000 |
Population based, prospective study of the care of women with epilepsy in pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fetal Death; Guidelin | 2000 |
Inhibition of neuronal hypersynchrony in vitro differentiates levetiracetam from classical antiepileptic drugs.
Topics: Animals; Anticonvulsants; Calcium; Carbamazepine; Clonazepam; Electrophysiology; Epilepsy; Evoked Po | 2000 |
Treatment of comorbid bipolar disorder and epilepsy with valproate.
Topics: Anticonvulsants; Bipolar Disorder; Epilepsy; Humans; Valproic Acid | 2000 |
Carbamazepine and valproic acid: effects on the serum lipids and liver functions in children.
Topics: Adolescent; Analysis of Variance; Anticonvulsants; Carbamazepine; Chi-Square Distribution; Child; Ch | 2000 |
Current perception thresholds of epileptic patients treated with valproate.
Topics: Adolescent; Adult; Anticonvulsants; Case-Control Studies; Epilepsy; Epilepsy, Post-Traumatic; Humans | 2000 |
Effects of combined administration of zonisamide and valproic acid or phenytoin to nitric oxide production, monoamines and zonisamide concentrations in the brain of seizure-susceptible EL mice.
Topics: Animals; Anticonvulsants; Biogenic Monoamines; Brain; Disease Models, Animal; Drug Interactions; Dru | 2000 |
The role of tiagabine in the treatment of intractable epilepsy of childhood with multifocal independent spikes: a case report.
Topics: Anticonvulsants; Brain; Child; Drug Therapy, Combination; Electroencephalography; Epilepsy; Humans; | 2000 |
Renal tubular function in patients receiving anticonvulsant therapy: a long-term study.
Topics: Adolescent; Age Factors; Anticonvulsants; Carbamazepine; Child; Epilepsy; Female; Follow-Up Studies; | 2000 |
Serum sex hormone levels in young male patients with epilepsy receiving carbamazepine and valproic acid and after their withdrawal.
Topics: Adolescent; Antidepressive Agents; Carbamazepine; Epilepsy; Gonadal Steroid Hormones; Humans; Male; | 2000 |
Probenecid-inhibitable efflux transport of valproic acid in the brain parenchymal cells of rabbits: a microdialysis study.
Topics: Animals; Biological Transport, Active; Blood-Brain Barrier; Brain; Carrier Proteins; Cell Membrane; | 2000 |
Valproate prevents epileptiform activity after trauma in an in vitro model in neocortical slices.
Topics: Animals; Anticonvulsants; Brain Injuries; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; | 2000 |
Effects of antiepileptic drugs on evoked potentials in epileptic children.
Topics: Adolescent; Adult; Analysis of Variance; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Ep | 2000 |
Assessment of drug concentrations in tears in therapeutic drug monitoring: I. Determination of valproic acid in tears by gas chromatography/mass spectrometry with EC/NCI mode.
Topics: Anticonvulsants; Calibration; Drug Monitoring; Epilepsy; Gas Chromatography-Mass Spectrometry; Human | 2000 |
Independent short-term variability of spike-like (600 Hz) and postsynaptic (N20) cerebral SEP components.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Arousal; Carbamazepine; Cerebral Cortex; Epilepsy; Evoked | 2001 |
[Febrile pleuropericarditis during valproic acid treatment].
Topics: Anticonvulsants; Epilepsy; Female; Fever; Humans; Middle Aged; Pericarditis; Pleural Effusion; Valpr | 2001 |
Valproate treatment and the risk of hyperandrogenism and polycystic ovaries.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Hyperandrogenism; Polycystic Ovary Syndrome; Risk | 2000 |
Comparison the cognitive effect of anti-epileptic drugs in seizure-free children with epilepsy before and after drug withdrawal.
Topics: Anticonvulsants; Carbamazepine; Child; Cognition; Epilepsy; Event-Related Potentials, P300; Female; | 2001 |
Fetal valproate syndrome and autism: additional evidence of an association.
Topics: Autistic Disorder; Child; Child, Preschool; Developmental Disabilities; Epilepsy; Female; Follow-Up | 2001 |
Increased urinary excretion of tubular enzymes and proteins in children with epilepsy.
Topics: Acetylglucosaminidase; Adolescent; Alpha-Globulins; Anticonvulsants; Carbamazepine; Child; Child, Pr | 2000 |
The teratogenicity of anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Case-Control Studies; Congenital Abnorm | 2001 |
Nitroso-urea-cisplatin-based chemotherapy associated with valproate: increase of haematologic toxicity.
Topics: Adult; Aged; Anticonvulsants; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cispl | 2001 |
Pharmacokinetic interactions among phenobarbital, carbamazepine, and valproic acid in pediatric Japanese patients: clinical considerations on steady-state serum concentration-dose ratios.
Topics: Adolescent; Anticonvulsants; Biological Availability; Carbamazepine; Child; Dose-Response Relationsh | 2000 |
Antiepileptic drug therapy and its management in sudden unexpected death in epilepsy: a case-control study.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Case-Control Studies; Cohort Studies; Death, Sudd | 2001 |
Latent coeliac disease in a child with epilepsy, cerebral calcifications, drug-induced systemic lupus erythematosus and intestinal folic acid malabsorption associated with impairment of folic acid transport across the blood-brain barrier.
Topics: Adolescent; Anticonvulsants; Biological Transport; Blood-Brain Barrier; Brain; Brain Diseases; Calci | 2001 |
Effect of Antiepileptic drugs on plasma lipoprotein (a) and other lipid levels in childhood.
Topics: Adolescent; Analysis of Variance; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cholester | 2001 |
Repeated neural tube defects and valproate monotherapy suggest a pharmacogenetic abnormality.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Genetic Predisposition to Disease; Gravidity; Humans; Neur | 2001 |
Case reports.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Anticonvulsants; Child; Diagnosis, Differential; Epileps | 2001 |
Gender- or age-related binding characteristics of valproic acid to serum proteins in adult patients with epilepsy.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Blood Proteins; Epilepsy; Female; Humans; Mal | 2001 |
Valproate and the polycystic ovarian syndrome: final thoughts.
Topics: Adolescent; Adult; Anticonvulsants; Comorbidity; Epilepsy; Female; Humans; Middle Aged; Polycystic O | 2001 |
Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy.
Topics: Allosteric Regulation; Animals; Anticonvulsants; Benzodiazepinones; Desoxycorticosterone; Diazepam; | 2001 |
Absence epilepsy with fast rhythmic discharges during sleep: an intermediary form of generalized epilepsy?
Topics: Adult; Age of Onset; Anticonvulsants; Cerebral Cortex; Child; Child, Preschool; Diagnosis, Different | 2001 |
Severe, isolated thrombocytopenia under polytherapy with carbamazepine and valproate.
Topics: Aged; Anticonvulsants; Blood Platelets; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; | 2001 |
Characterization of reproductive endocrine disorders in women with epilepsy.
Topics: Adolescent; Adult; Amenorrhea; Anticonvulsants; Endocrine System Diseases; Epilepsy; Female; Humans; | 2001 |
Thyroid hormones in epileptic children receiving carbamazepine and valproic acid.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Case-Control Studies; Child; Drug Interactions; Drug The | 2001 |
Thyroid function in men taking carbamazepine, oxcarbazepine, or valproate for epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Enzyme Induction; Epilepsy; gamma-Glutamyltransfe | 2001 |
Epilepsy.
Topics: Anticonvulsants; Automobile Driving; Epilepsy; Female; Guidelines as Topic; Humans; Phenytoin; Valpr | 2001 |
Early hormonal changes during valproate or carbamazepine treatment: a 3-month study.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Hormones; Humans; Male; Time Fa | 2001 |
Decreased bone mass and increased bone turnover with valproate therapy in adults with epilepsy.
Topics: Adult; Anticonvulsants; Bone and Bones; Bone Density; Epilepsy; Female; Humans; Male; Middle Aged; V | 2001 |
Weight change associated with valproate and lamotrigine monotherapy in patients with epilepsy.
Topics: Anticonvulsants; Body Weight; Epilepsy; Humans; Triazines; Valproic Acid | 2001 |
[Depakene (sodium valproate) in the treatment of epilepsy in children and adolescents: efficiency and safety].
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Administration Schedule; Epilepsy; | 2001 |
[The dangers of valproate in women].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Cholesterol, HDL; Epilepsy; Female; Humans; Hyperandro | 1998 |
Hormone profiles in young adults with epilepsy treated with sodium valproate or lamotrigine monotherapy.
Topics: Adult; Anticonvulsants; Blood Glucose; Body Mass Index; Comorbidity; Dehydroepiandrosterone; Epileps | 2001 |
Are serum anticonvulsant levels in people with epilepsy appropriately monitored?
Topics: Anticonvulsants; Drug Monitoring; Epilepsy; Humans; Logistic Models; Phenytoin; Valproic Acid | 2001 |
Altered ovarian function and cardiovascular risk factors in valproate-treated women.
Topics: Adult; Analysis of Variance; Anticonvulsants; Carbamazepine; Cardiovascular Diseases; Case-Control S | 2001 |
Long-term valproate and lamotrigine treatment may be a marker for reduced growth and bone mass in children with epilepsy.
Topics: Adolescent; Anticonvulsants; Bone and Bones; Bone Density; Bone Diseases, Developmental; Bone Diseas | 2001 |
[Fatal necro-hemorrhagic pancreatitis related to sodium valproate: case report].
Topics: Acute Disease; Anticonvulsants; Child; Epilepsy; Fatal Outcome; Humans; Male; Necrosis; Pancreatitis | 2001 |
Craniosynostosis and fetal exposure to sodium valproate.
Topics: Anticonvulsants; Child; Child, Preschool; Craniosynostoses; Epilepsy; Female; Fetus; Humans; Infant; | 2001 |
[Analogs of generic preparations for the treatment of epilepsy: is their use safe?].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Child; Child, Preschool; | 2001 |
Analysis of the musculoskeletal system in children and adolescents receiving anticonvulsant monotherapy with valproic acid or carbamazepine.
Topics: Adolescent; Alkaline Phosphatase; Amino Acids; Anticonvulsants; Biomarkers; Bone Density; Bone Resor | 2001 |
Effectiveness of first antiepileptic drug.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Dose-Response Relationship, Drug; Electroe | 2001 |
Fatal cardiac malformation in fetal valproate syndrome.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Epilepsy; Fatal Outcome; Female; Heart Defects, | 2001 |
[The pharmacological and hormonal effects of carbamazepine and valproic acid in the treatment of reproductive age women with epilepsy].
Topics: Adult; Anticonvulsants; Carbamazepine; Endocrine System Diseases; Epilepsy; Estradiol; Female; Folli | 2001 |
Methsuximide reduces valproic acid serum levels.
Topics: Adolescent; Adult; Anticonvulsants; Child; Drug Interactions; Epilepsy; Female; Humans; Male; Succin | 2001 |
Serum copper, zinc, selenium, glutathione peroxidase and superoxide dismutase levels in epileptic children before and after 1 year of sodium valproate and carbamazepine therapy.
Topics: Adolescent; Analysis of Variance; Anticonvulsants; Carbamazepine; Copper; Epilepsy; Female; Glutathi | 2002 |
Hyperandrogenism, postprandial hyperinsulinism and the risk of PCOS in a cross sectional study of women with epilepsy treated with valproate.
Topics: Adult; Anticonvulsants; Body Mass Index; Body Weight; Confidence Intervals; Cross-Sectional Studies; | 2002 |
Effect of anticonvulsant drugs on interleukins-1, -2 and -6 and monocyte chemoattractant protein-1.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Chemokine CCL2; Child; Epilepsy; Female; Humans; Interle | 2001 |
Effect of L-carnitine treatment for valproate-induced hepatotoxicity.
Topics: Anticonvulsants; Carnitine; Chemical and Drug Induced Liver Injury; Epilepsy; Humans; Liver Diseases | 2002 |
Tricarboxylic acid cycle of glia in the in vivo human brain.
Topics: Acetates; Adult; Bicarbonates; Brain; Carbon Isotopes; Citric Acid Cycle; Epilepsy; Female; Glutamic | 2002 |
[Pharmacokinetic aspects of carbamazepine and valproic acid using in reproductive-age women with epilepsy].
Topics: Adult; Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Epilepsy; Female; Ferti | 2002 |
Serum lipid changes during anticonvulsive treatment serum lipids in epileptic children.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cholesterol; Cholesterol, HDL; | 2001 |
[Monitoring of renal function in epileptic children and teenagers treated with valproic acid or carbamazepine in concomitant therapy with tiagabine].
Topics: Acetylglucosaminidase; Adolescent; Adult; Anticonvulsants; beta 2-Microglobulin; Carbamazepine; Case | 2001 |
Coagulation abnormalities and acquired von Willebrand's disease type 1 in children receiving valproic acid.
Topics: Adolescent; Anticonvulsants; Antigens; Blood Coagulation Tests; Child; Child, Preschool; Dose-Respon | 2002 |
[Treatment of newly diagnosed epileptic crises. A French experience].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Child; Child, Preschool; | 2001 |
[Treatment of epileptic seizures resistant to phenobarbital in children during the first year of life].
Topics: Anticonvulsants; Drug Resistance; Epilepsy; Humans; Infant; Phenobarbital; Prospective Studies; Seiz | 2002 |
Coma probably induced by lorazepam-valproate interaction.
Topics: Adult; Anticonvulsants; Coma; Drug Interactions; Epilepsy; Female; Humans; Lorazepam; Valproic Acid | 2002 |
Topiramate enhances the risk of valproate-associated side effects in three children.
Topics: Affective Symptoms; Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Therapy, Combinati | 2002 |
Pancreatitis complicating treatment with intravenous valproic acid.
Topics: Adult; Aged; Epilepsy; Female; Humans; Injections, Intravenous; Male; Middle Aged; Pancreatitis; Val | 2002 |
Bone mineral status in ambulatory pediatric patients on long-term anti-epileptic drug therapy.
Topics: Absorptiometry, Photon; Adolescent; Anticonvulsants; Biomarkers; Bone Density; Bone Diseases, Metabo | 2002 |
[Visual field defect in a patient given sodium valporate then carbamazepine: possible effect of aminotransferase inhibition].
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Anticonvulsants; Carbamazepine; Drug Therapy, Combinati | 2002 |
Ophthalmic findings in fetal anticonvulsant syndrome(s).
Topics: Abnormalities, Drug-Induced; Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Ep | 2002 |
Reversible valproate-induced choreiform movements.
Topics: Adult; Anticonvulsants; Chorea; Craniocerebral Trauma; Epilepsy; Humans; Male; Time Factors; Valproi | 2002 |
Do structural properties explain the anticonvulsant activity of valproate metabolites? A QSAR analysis.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Epilepsy; Humans; Isomerism; Male; Mice; Quantitative | 2002 |
Serum insulin and leptin levels in valproate-associated obesity.
Topics: Adult; Body Mass Index; Body Weight; Epilepsy; Female; Humans; Insulin; Insulin Resistance; Leptin; | 2002 |
Valproic acid and risperidone.
Topics: Adolescent; Anticonvulsants; Antipsychotic Agents; Drug Interactions; Epilepsy; Female; Humans; Psyc | 2002 |
Insulin resistance in epileptic girls who gain weight after therapy with valproic acid.
Topics: Androgens; Anticonvulsants; Blood Glucose; Body Mass Index; Child; Epilepsy; Female; Follicle Stimul | 2002 |
Visual functions in epilepsy patients on valproate monotherapy.
Topics: Adolescent; Adult; Anticonvulsants; Electroretinography; Epilepsy; Female; Humans; Male; Reference V | 2002 |
Deepening coma in an epileptic patient: the missing link to the urea cycle. Hyperammonaemic metabolic encephalopathy.
Topics: Anticonvulsants; Atrophy; Cerebellum; Coma; Epilepsy; Female; Humans; Hyperammonemia; Middle Aged; T | 2002 |
[Adverse effects of anti-epileptic drugs].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Carbamazepine; Diazepam; Epilepsy; Ethos | 1975 |
Prognosis and therapy of complex partial seizures with barbiturates, hydantoins, and other drugs.
Topics: Anticonvulsants; Barbiturates; Benzodiazepines; Drug Therapy, Combination; Epilepsy; Epilepsy, Tempo | 1975 |
Use of anticonvulsant drugs.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Epilepsy; Ethosuximide; Humans; Phenobarbital | 1979 |
Proceedings: Sodium valproate (Epilim) and photosensitivity. A preliminary report.
Topics: Electroencephalography; Epilepsy; Humans; Valerates; Valproic Acid | 1975 |
Proceedings: Sodium valproate (Epilim) in the treatment of intractable epilepsy, including some observations on blood levels.
Topics: Epilepsy; Humans; Valerates; Valproic Acid | 1975 |
Proceedings: The effect of sodium valproate (Epilim) on the EEG.
Topics: Electroencephalography; Epilepsy; Humans; Valerates; Valproic Acid | 1975 |
Letter: Valproate in the U.S.A.
Topics: Drug and Narcotic Control; Drug Industry; Epilepsy; Humans; United States; Valerates; Valproic Acid | 1976 |
Valproate may lower serum-phenytoin.
Topics: Drug Interactions; Epilepsy; Humans; Phenytoin; Valerates; Valproic Acid | 1976 |
Dipropylacetate (valproate) and glycine metabolism.
Topics: Epilepsy; Glycine; Humans; Infant; Valerates; Valproic Acid | 1977 |
Sodium valproate in epilepsy.
Topics: Drug Evaluation; Epilepsy; Humans; Valerates; Valproic Acid | 1977 |
Sodium valproate and platelet-count.
Topics: Child; Epilepsy; Female; Humans; Male; Thrombocytopenia; Valerates; Valproic Acid | 1978 |
Effects of anticonvulsant drugs on thyroid hormones in epileptic children.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Cholesterol; Dose-Response Relationship, Drug; Dr | 1978 |
Lowered erythrocyte-sedimentation rate with sodium valproate.
Topics: Afibrinogenemia; Blood Sedimentation; Epilepsy; Humans; Valproic Acid | 1978 |
Treatment of childhood epilepsy with dipropylacetic acid (DPA).
Topics: Adolescent; Adult; Child; Child, Preschool; Electroencephalography; Epilepsies, Myoclonic; Epilepsy; | 1978 |
Sodium valproate (Epilim) in epilepsy: a trial.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Cloni | 1978 |
Clinical efficacy of valproic acid in relation to plasma levels.
Topics: Adolescent; Adult; Epilepsies, Myoclonic; Epilepsy; Epilepsy, Absence; Female; Humans; Male; Valproi | 1978 |
Pattern sensitive epilepsy: a case report.
Topics: Child; Electroencephalography; Epilepsy; Epilepsy, Absence; Female; Form Perception; Humans; Light; | 1979 |
Macaca fascicularis: alternative epileptic model.
Topics: Animals; Brain; Disease Models, Animal; Electroencephalography; Epilepsy; Haplorhini; Macaca; Macaca | 1979 |
Sodium valproate.
Topics: Adult; Animals; Brain; Child; Epilepsy; Epilepsy, Absence; Female; Hemostasis; Humans; Pregnancy; Va | 1979 |
Sodium valproate and hepatotoxicity in epileptics.
Topics: Adolescent; Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Child; Drug Therapy, Com | 1979 |
Acute intoxication with sodium valproate.
Topics: Acute Disease; Adolescent; Adult; Brain Diseases; Epilepsy; Female; Humans; Male; Valproic Acid | 1979 |
Sodium valproate, pregnancy, and neonatal hyperglycinaemia.
Topics: Adult; Epilepsy; Female; Glycine; Humans; Infant, Newborn; Infant, Newborn, Diseases; Pregnancy; Pre | 1979 |
Comparative steady state serum levels of valproic acid administered as two different formulations--Deprakine and Orfiril.
Topics: Absorption; Adolescent; Adult; Biological Availability; Epilepsy; Female; Gastric Mucosa; Humans; Ma | 1979 |
Some aspects of the clinical use of clonazepam in refractory epilepsy.
Topics: Adolescent; Adult; Ataxia; Benzodiazepinones; Child; Clonazepam; Depression; Drug Therapy, Combinati | 1979 |
[Domestically produced sodium n-dipropylacetate in treating epilepsy (author's transl)].
Topics: Adolescent; Adult; Brain Chemistry; Child; Child, Preschool; Epilepsy; Female; gamma-Aminobutyric Ac | 1979 |
Valproic acid-phenytoin interaction.
Topics: Adult; Chromatography, Gas; Drug Interactions; Epilepsy; Humans; Monitoring, Physiologic; Phenytoin; | 1979 |
[Antiepileptic therapy with valproinic acid. Correlations of side effects and serum levels of valproinic acid].
Topics: Acne Vulgaris; Anemia, Aplastic; Epilepsy; Fatigue; Gastrointestinal Diseases; Humans; Leukopenia; T | 1979 |
[Drug therapy of epilepsy].
Topics: Age Factors; Anticonvulsants; Barbiturates; Benzodiazepines; Bromides; Carbamazepine; Chlormethiazol | 1977 |
Drug interactions during anticonvulsant therapy in childhood: diphenylhydantoin, primidone, phenobarbitone, clonazepam, nitrazepam, carbamazepin and dipropylacetate.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Drug Interactions; | 1977 |
Early experience with sodium valproate.
Topics: Epilepsy; Humans; Valerates; Valproic Acid | 1977 |
Management of childhood epilepsy.
Topics: Child; Epilepsy; Humans; Phenobarbital; Phenytoin; Valproic Acid | 1977 |
Implications of measuring anticonvulsant blood levels in epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Epilepsy; Humans; Middle Aged; Patient Compliance; | 1977 |
[Study of the immunosuppressive effect of some anticonvulsants in children].
Topics: Adolescent; Anticonvulsants; B-Lymphocytes; Child; Child, Preschool; Epilepsy; Female; Humans; Immun | 1977 |
Preliminary observations on valproic acid kinetics in patients with epilepsy.
Topics: Adult; Child; Chromatography, Gas; Epilepsy; Humans; Phenobarbital; Phenytoin; Valerates; Valproic A | 1977 |
Pharmacokinetic studies with valproic acid in man.
Topics: Adult; Child; Child, Preschool; Chromatography, Gas; Epilepsy; Extracellular Space; Half-Life; Human | 1977 |
[Studies on the urinary excretion of metabolites of valproic acid (dipropylacetic acid) in rats and humans (author's transl)].
Topics: Adipates; Animals; Epilepsy; Glutarates; Humans; Kidney; Malonates; Rats; Succinates; Valerates; Val | 1977 |
[Thrombocyte values in adults during the treatment with DPA (Ergenyl)].
Topics: Adolescent; Adult; Blood Platelets; Dose-Response Relationship, Drug; Epilepsy; Humans; Middle Aged; | 1977 |
Plasma levels of di-no-propylacetate and clonazepam in epileptic patients.
Topics: Adolescent; Adult; Benzodiazepinones; Child; Clonazepam; Epilepsy; Female; Humans; Male; Valerates; | 1977 |
Epilepsy and IgA deficiency--the effect of sodium valproate.
Topics: Adult; Agammaglobulinemia; Carbamazepine; Epilepsy; Female; Humans; Immunoglobulin A; Male; Phenobar | 1977 |
Choice of drug therapy in epilepsy.
Topics: Acetazolamide; Anticonvulsants; Benzodiazepines; Carbamazepine; Clonazepam; Epilepsy; Ethosuximide; | 1977 |
[Plasma levels of anticonvulsants. Experiences with routine plasma level determination of 6 different anticonvulsants].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Epilepsy; Ethos | 1978 |
[Study of the therapeutic action and side-effects of a new preparation of dipropylacetic acid].
Topics: Adolescent; Adult; Child; Epilepsy; Female; Gastrointestinal Diseases; Humans; Male; Valerates; Valp | 1977 |
Serum protein binding of diphenylhydantoin in man. I. Interaction with sodium valproate.
Topics: Drug Interactions; Epilepsy; Humans; In Vitro Techniques; Phenytoin; Protein Binding; Valerates; Val | 1978 |
Sodium valproate (Epilim) in the treatment of refractory epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Interactions; Epilepsy; Female; Humans; M | 1978 |
Steady-state kinetics of valproic acid in epileptic patients.
Topics: Adolescent; Adult; Epilepsy; Female; Half-Life; Humans; Kinetics; Male; Models, Biological; Valproic | 1978 |
A brief review of valproate. A new anticonvulsant.
Topics: Adolescent; Adult; Anticonvulsants; Child; Drug Evaluation; Epilepsy; Female; Humans; Male; Valproic | 1978 |
Effect of valproic acid on hepatic function.
Topics: Adolescent; Adult; Alanine Transaminase; Aspartate Aminotransferases; Epilepsy; Female; Humans; Live | 1978 |
Plasma sodium valproate levels and clinical response in epilepsy.
Topics: Anticonvulsants; Drug Therapy, Combination; Epilepsy; Humans; Valproic Acid | 1977 |
Long-term use of the major anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Drug Interactions; Epilepsy; Ethosuximi | 1978 |
Valproic acid: a brief review.
Topics: Dose-Response Relationship, Drug; Drug Evaluation; Epilepsy; Humans; Valproic Acid | 1978 |
[Studies on the therapeutic scope of valproic acid].
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Male; M | 1979 |
Concomitant use of clonazepam and valproic acid in treatment of epileptic seizures.
Topics: Benzodiazepinones; Child; Clonazepam; Drug Therapy, Combination; Epilepsy; Humans; Male; Valproic Ac | 1979 |
[Dipropylacetate (sodium valproate) and carbamazepine : a suspicious anticonvulsant combination].
Topics: Carbamazepine; Cognition Disorders; Confusion; Drug Therapy, Combination; Epilepsy; Humans; Male; Mi | 1978 |
Valproic acid: a new antiepileptic agent.
Topics: Drug Interactions; Epilepsy; Humans; Valproic Acid | 1979 |
A controlled study of the effect of sodium valproate on photosensitive epilepsy and its prognosis.
Topics: Adolescent; Adult; Child; Electroencephalography; Epilepsy; Evoked Potentials; Female; Follow-Up Stu | 1978 |
Consensus on valproic acid: a versatile anticonvulsant.
Topics: Adolescent; Adult; Epilepsy; Humans; Middle Aged; Valproic Acid | 1978 |
Drugs for epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Epilepsy; Ethosuximide; Humans; Phenobarbital; | 1979 |
Effects of valproate and ethosuximide on thalamocortical excitability.
Topics: Animals; Cats; Cerebral Cortex; Epilepsy; Ethosuximide; Thalamus; Valproic Acid | 1979 |
Recent advances in drug therapy for epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Drug Interactions; Epilepsy; Humans; Phenobarbital; Phen | 1979 |
Valproic acid in epilepsy.
Topics: Child; Epilepsy; Humans; Valproic Acid | 1979 |
Acute hepatic failure associated with the use of sodium valproate.
Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Epilepsy; Humans; Li | 1979 |
Sodium valproate and pregnancy.
Topics: Adult; Breast Feeding; Epilepsy; Female; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Mil | 1979 |
Epilepsy and learning.
Topics: Adolescent; Child; Epilepsy; Humans; Learning; Valproic Acid | 1979 |
Side effects of sodium valproate (sodium di-N-propylacetate) on malonyldialdehyde-production and other platelet function tests.
Topics: Adult; Blood Platelet Disorders; Blood Platelets; Child; Epilepsy; Factor IX; Factor VIII; Fibrinoge | 1978 |
The use of antiepileptic drugs.
Topics: Anticonvulsants; Benzodiazepines; Carbamazepine; Drug Interactions; Epilepsy; Ethosuximide; Humans; | 1979 |
Comparative trial of valproate sodium and clonazepam in chronic epilepsy.
Topics: Adult; Ataxia; Benzodiazepinones; Chronic Disease; Clonazepam; Drug Therapy, Combination; Epilepsy; | 1979 |
"Epilim" in intractable epilepsy of childhood.
Topics: Child; Epilepsy; Humans; Valproic Acid | 1979 |
[Valproate (dipropyl acetate)--a new-series antiepileptic drug].
Topics: Anticonvulsants; Chemical Phenomena; Chemistry; Drug Interactions; Epilepsy; Humans; Valproic Acid | 1979 |
Serum protein binding of diphenylhydantoin in man. II. Interaction with sodium valproate in epileptic patients.
Topics: Adult; Binding, Competitive; Drug Interactions; Epilepsy; Female; Humans; Male; Middle Aged; Phenyto | 1979 |
[Transitory medullary hypoplasia induced by sodium dipropylacetate (author's transl)].
Topics: Bone Marrow; Child; Epilepsy; Humans; Male; Pancytopenia; Purpura, Thrombocytopenic; Remission, Spon | 1979 |
Combination of clonazepam and sodium valproate in the treatment of refractory epileptic seizures in 12 children.
Topics: Benzodiazepinones; Child; Clonazepam; Drug Therapy, Combination; Epilepsy; Humans; Seizures; Valproi | 1979 |
A direct hepatotoxic effect of valproic acid.
Topics: Adolescent; Adult; Alkaline Phosphatase; Blood Coagulation Tests; Child; Dose-Response Relationship, | 1979 |
Reye-like syndrome associated with valproic acid therapy.
Topics: Chemical and Drug Induced Liver Injury; Child; Epilepsy; Female; Humans; Reye Syndrome; Valproic Aci | 1979 |
Lack of hepatic enzyme inducing effect of sodium valproate.
Topics: Adult; Antipyrine; Enzyme Induction; Epilepsy; Female; Glucaric Acid; Half-Life; Humans; Liver; Male | 1979 |
Dipropylacetate and hyperglycinemia.
Topics: Adolescent; Child; Epilepsy; Glycine; Humans; Valproic Acid | 1979 |
Recent advances in drug therapy of some forms of childhood epilepsy.
Topics: Anticonvulsants; Carbamazepine; Child; Clonazepam; Diazepam; Drug Therapy, Combination; Epilepsy; Hu | 1979 |
Sodium valproate: dose-plasma level relationships and interdose fluctuations.
Topics: Adolescent; Adult; Anticonvulsants; Child; Drug Therapy, Combination; Epilepsy; Female; Humans; Male | 1978 |
Side effects of sodium valproate during long-term treatment in epilepsy.
Topics: Adolescent; Adult; Aggression; Brain; Epilepsy; Female; Humans; Male; Middle Aged; Time Factors; Val | 1979 |
Single and chronic dose pharmacokinetic studies of sodium valproate in epileptic patients.
Topics: Adult; Drug Interactions; Epilepsy; Half-Life; Humans; Kinetics; Male; Middle Aged; Time Factors; Va | 1979 |
Simple gas-chromatographic measurement of valproic acid in psychiatric patients: effect on levels of other simultaneously administered anticonvulsants.
Topics: Adult; Anticonvulsants; Chromatography, Gas; Drug Therapy, Combination; Epilepsy; Humans; Middle Age | 1979 |
Decreased plasma protein binding of phenytoin in patients on valproic acid.
Topics: Adolescent; Adult; Blood Proteins; Child; Creatinine; Depression, Chemical; Epilepsy; Humans; Phenyt | 1979 |
Sodium valproate and clonazepam in the treatment of intractable epilepsy.
Topics: Adolescent; Adult; Benzodiazepinones; Child; Clonazepam; Drug Evaluation; Epilepsy; Epilepsy, Absenc | 1977 |
Treatment of generalized epilepsies of childhood and adolescence with sodium valproate ("epilim").
Topics: Adolescent; Automatism; Child; Drug Evaluation; Electroencephalography; Epilepsies, Myoclonic; Epile | 1977 |
[The treatment of primary generalized epilepsies with dipropyl acetate (DPA)].
Topics: Adolescent; Child; Child, Preschool; Drug Evaluation; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-C | 1977 |
Sodium valproate for the treatment of childhood epilepsies.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Interactions; Epilepsies, Myoclonic; Epil | 1977 |
The anticonvulsant action of sodium valproate (Epilim) in 100 patients with various forms of epilepsy.
Topics: Adolescent; Adult; Child; Epilepsies, Myoclonic; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lob | 1977 |
[Clinical study of serum level of dipropylacetic acid sodium (Depakene) by gaschromatography (author's transl)].
Topics: Adolescent; Adult; Child; Child, Preschool; Chromatography, Gas; Drug Therapy, Combination; Epilepsi | 1977 |
Sodium valproate in the treatment of intractable seizure disorders: a clinical and electroencephalographic study.
Topics: Adult; Drug Evaluation; Electroencephalography; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; | 1978 |
[Measurement of the blood concentration of antiepileptic drugs. II Special cases].
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Epilepsy; Ethosuximide; Humans; Phenobarbi | 1975 |
[Myoclonic cerebellar dyssynergia with epilepsy (Ramsey-Hunt syndrome). Electro-clinical study in a patient of the black race].
Topics: Adult; Black People; Cerebellar Ataxia; Electroencephalography; Epilepsy; Female; Humans; Phenobarbi | 1975 |
The use of sodium valproate in a case of status epilepticus.
Topics: Child; Epilepsy; Female; Humans; Intubation, Gastrointestinal; Nose; Valerates; Valproic Acid | 1976 |
Pharmacokinetics of di-n-propylacetate in epileptic patients.
Topics: Administration, Oral; Aged; Body Weight; Child; Child, Preschool; Dose-Response Relationship, Drug; | 1975 |
[Changes in hemostasis during epilespy treatment using dipropyl acetate. Extended study].
Topics: Adolescent; Blood Cell Count; Blood Platelets; Child; Child, Preschool; Epilepsy; Factor IX; Female; | 1976 |
Proposals on antiepileptic pharmacotherapy for use in developing countries.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Developing Countries; Diazepam | 1976 |
The anticonvulsant effect of sodium valproate and clonazepam in the management of intractable epilepsy.
Topics: Benzodiazepinones; Clonazepam; Drug Evaluation; Epilepsy; Humans; Valerates; Valproic Acid | 1976 |
The treatment of childhood epilepsy with sodium valproate.
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, | 1975 |
[Austrian complex-study on dipropylacetate. Pediatric experiences].
Topics: Austria; Child; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Humans | 1976 |
Sodium valproate in the management of intractable epilepsy: comparison with clonazepam.
Topics: Adolescent; Adult; Benzodiazepinones; Child; Clonazepam; Epilepsy; Epilepsy, Tonic-Clonic; Female; H | 1975 |
Sodium valproate in the treatment of resistant epilepsy.
Topics: Adolescent; Adult; Alopecia; Anticonvulsants; Body Weight; Diarrhea; Drug Interactions; Epilepsies, | 1976 |
Early experience with sodium valproate.
Topics: Adolescent; Adult; Child; Child, Preschool; Chronic Disease; Epilepsies, Partial; Epilepsy; Humans; | 1976 |
[The effect of dipropyl acetic acid (Convules) in epileptic adults with a high frequency of seizures].
Topics: Adult; Aged; Barbiturates; Epilepsies, Partial; Epilepsy; Epilepsy, Temporal Lobe; Epilepsy, Tonic-C | 1976 |
Sodium valproate in the treatment of intractable childhood epilepsy.
Topics: Adolescent; Brain; Child; Child, Preschool; Drug Evaluation; Electroencephalography; Epilepsy; Human | 1975 |
Letter: Preliminary experience with sodium valproate.
Topics: Adolescent; Adult; Anticonvulsants; Child; Drug Therapy, Combination; Epilepsy; Female; Humans; Male | 1975 |
[Thrombocyte values during ergenyl treatment].
Topics: Anticonvulsants; Blood Cell Count; Blood Platelets; Child; Child, Preschool; Epilepsy; Humans; Throm | 1975 |
Letter: Sodium valproate in the treatment of intractable childhood epilepsy.
Topics: Diazepam; Drug Therapy, Combination; Epilepsy; Phenobarbital; Phenytoin; Primidone; Pyridoxine; Vale | 1975 |
Elevation of diphenylhydantoin and primidone serum concentration by addition of dipropylacetate, a new anticonvulsant drug.
Topics: Child; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Phenytoin; Primidone; Valerat | 1975 |
Sodium valproate and clonazepam for epilepsy.
Topics: Adult; Benzodiazepinones; Child; Clonazepam; Epilepsy; Humans; Valproic Acid | 1975 |
Concentration of dipropylacetate in plasma.
Topics: Administration, Oral; Dose-Response Relationship, Drug; Epilepsy; Humans; Time Factors; Valerates; V | 1975 |
Influence of phenobarbital on ECoG phenomena induced by metrazol in rats during ontogenesis.
Topics: Aging; Animals; Cerebral Cortex; Clonazepam; Disease Models, Animal; Dose-Response Relationship, Dru | 1992 |
Treatment of epilepsy.
Topics: Adult; Carbamazepine; Epilepsy; Female; Humans; Male; Phenytoin; Valproic Acid | 1992 |
Detection by HPLC-ICP of metallothionein in serum of an epileptic child with valproate-associated hepatotoxicity.
Topics: Blood Proteins; Child; Chromatography, High Pressure Liquid; Copper; Epilepsy; Hepatic Encephalopath | 1992 |
Cognitive functions, epileptic syndromes and antiepileptic drugs.
Topics: Adolescent; Adult; Carbamazepine; Child; Cognition; Epilepsy; Female; Humans; Male; Middle Aged; Phe | 1992 |
Involvement of GABA-dependent chloride channel in the action of anticonvulsant and convulsant drugs.
Topics: Animals; Anticonvulsants; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebr | 1992 |
What to do when the first anticonvulsant does not work.
Topics: Aminocaproates; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Lamotrigine; Phenytoin; Treatment | 1992 |
Therapeutic drug monitoring improves seizure control and reduces anticonvulsant side-effects in patients with refractory epilepsy.
Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Monitoring; Electroencephalog | 1992 |
Increased cortical excitability in generalised epilepsy demonstrated with transcranial magnetic stimulation.
Topics: Cerebral Cortex; Electric Stimulation; Epilepsy; Humans; Seizures; Transcranial Magnetic Stimulation | 1992 |
Sister-chromatid exchanges are increased in epileptics, but not by sodium valproate.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Child; Epilepsy; Humans; Leukocytes; Middle Aged; Mut | 1992 |
Variability and clinical relevance of the interaction between sodium valproate and carbamazepine in epileptic patients.
Topics: Adolescent; Adult; Carbamazepine; Cognition; Drug Interactions; Epilepsy; Female; Humans; Male; Midd | 1992 |
Valproate acute administration, EEG epileptic abnormalities, and ammonemia.
Topics: Adolescent; Adult; Ammonia; Electroencephalography; Epilepsy; Female; Humans; Male; Valproic Acid | 1992 |
The effect of anticonvulsants on EEG background activity in epileptic children with monopharmacy.
Topics: Adolescent; Analysis of Variance; Carbamazepine; Child; Electroencephalography; Epilepsy; Humans; Va | 1992 |
Increased aspartate release from brain slices of epileptic experimental animals and effect of valproate on it.
Topics: Animals; Aspartic Acid; Brain; Disease Models, Animal; Epilepsy; In Vitro Techniques; Mice; Mice, Ne | 1992 |
Changes in unbound and total valproic acid concentrations after replacement of carbamazepine with oxcarbazepine.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combinat | 1992 |
Relationship between serum concentration and dose of valproic acid during monotherapy in adult outpatients.
Topics: Adult; Aged; Dose-Response Relationship, Drug; Epilepsy; Female; Genetic Variation; Humans; Male; Mi | 1992 |
The disposition of valproate and its metabolites in the late first trimester and early second trimester of pregnancy in maternal serum, urine, and amniotic fluid: effect of dose, co-medication, and the presence of spina bifida.
Topics: Amniocentesis; Amniotic Fluid; Drug Therapy, Combination; Epilepsy; Female; Gas Chromatography-Mass | 1992 |
Chromosome fragility in the Lennox-Gastaut epilepsy syndrome.
Topics: Adolescent; Adult; Chromosome Aberrations; Chromosome Banding; Chromosome Fragile Sites; Chromosome | 1992 |
Cerebral cavernous angioma: a potentially benign condition? Successful treatment in 16 cases.
Topics: Adolescent; Adult; Angiography; Brain Neoplasms; Carbamazepine; Cerebral Hemorrhage; Child; Epilepsy | 1992 |
Psychological effects of sodium valproate and carbamazepine in epilepsy.
Topics: Carbamazepine; Child; Child Behavior; Child, Preschool; Cognition; Epilepsy; Female; Humans; Intelli | 1992 |
The effect of carnitine on the metabolism of valproic acid in epileptic patients.
Topics: Adolescent; Adult; Carnitine; Child; Epilepsy; Female; Half-Life; Humans; Male; Valproic Acid | 1992 |
Cognitive effects of antiepileptic drug discontinuation.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Cognition; Cognition Disorders; Epilepsy; Humans; | 1992 |
Neural tube defects in association with epilepsy and its treatment.
Topics: Epilepsy; Female; Humans; Neural Tube Defects; Pregnancy; Pregnancy Complications; Valproic Acid | 1992 |
Fatal pancytopenia during high-dose valproate monotherapy.
Topics: Child, Preschool; Epilepsy; Female; Humans; Pancytopenia; Valproic Acid | 1992 |
Changes in cognitive functions in epileptics on sodium valproate monotherapy.
Topics: Adolescent; Adult; Cognition; Epilepsy; Female; Humans; Male; Valproic Acid | 1992 |
Interactions between clobazam and standard antiepileptic drugs in patients with epilepsy.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbama | 1992 |
[Disseminated intravascular coagulation in an epileptic infant under the treatment with sodium valproate].
Topics: Disseminated Intravascular Coagulation; Drug Eruptions; Epilepsy; Female; Humans; Infant; Valproic A | 1992 |
Pharmacokinetics, anticonvulsant efficacy, and adverse effects of trans-2-en-valproate after acute and chronic administration in amygdala-kindled rats.
Topics: Amygdala; Animals; Epilepsy; Female; Injections, Intraperitoneal; Kindling, Neurologic; Muscle Relax | 1992 |
Spectrum of neural-tube defects in 34 infants prenatally exposed to antiepileptic drugs.
Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Infant; Infant, | 1992 |
The risk of spina bifida aperta after first-trimester exposure to valproate in a prenatal cohort.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Fetal Diseases; Humans; Infant; Infant, Newborn; Male; Pre | 1992 |
Antiepileptics and the development of congenital anomalies.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Apgar Score; Birth Weight; Carbamazepine; Epilepsy; Fe | 1992 |
Epilepsy, antiepileptic drugs, and malformations in children of women with epilepsy: a French prospective cohort study.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Cohort Studies; Epilepsy; Female; Humans; Odds | 1992 |
Antiepileptic drugs and teratogenesis in two consecutive cohorts: changes in prescription policy paralleled by changes in pattern of malformations.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Cohort Studies; Drug Prescriptions; Epi | 1992 |
Clinical utility of unbound antiepileptic drug blood levels in the management of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Humans; Phenytoin; Valproic Aci | 1992 |
Anticonvulsant-induced chronic pancreatitis. A case report.
Topics: Adult; Anticonvulsants; Carbamazepine; Chronic Disease; Cytochrome P-450 Enzyme System; Epilepsy; Fr | 1992 |
Flunarizine--effective add-on therapy in reading epilepsy.
Topics: Adult; Drug Therapy, Combination; Electroencephalography; Epilepsy; Flunarizine; Humans; Male; Readi | 1992 |
Valproic-acid-induced pancytopenia and Coombs test positivity.
Topics: Adolescent; Coombs Test; Epilepsy; Female; Humans; Pancytopenia; Valproic Acid | 1991 |
Influence of antiepileptic drugs on sleep patterns.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Brain; Carbamazepine; Chil | 1991 |
Antiepileptic activity of 1,3-dihexadecanoylamino-2-valproyl-propan-2-ol, a prodrug of valproic acid endowed with a tropism for the central nervous system.
Topics: Administration, Oral; Animals; Anticonvulsants; Central Nervous System; Drug Design; Electroshock; E | 1991 |
Anticonvulsant activity of di-n-propylacetate and brain monoamine metabolism in the rat.
Topics: Animals; Biogenic Monoamines; Brain; Catecholamines; Epilepsy; Female; gamma-Aminobutyric Acid; Homo | 1990 |
Guanidino compound levels in the serum of healthy adults and epileptic patients.
Topics: Adult; Arginine; Creatinine; Epilepsy; Female; Glycine; Guanidines; Homoarginine; Humans; Male; Phen | 1991 |
Pattern- and age-dependency of the antiepileptic effects induced by valproic acid in the rat hippocampus.
Topics: 4-Aminopyridine; Age Factors; Animals; Epilepsy; Hippocampus; Rats; Rats, Inbred Strains; Valproic A | 1991 |
Influence of concurrent administration of sodium valproate on the plasma concentrations of carbamazepine and its epoxide and diol metabolites.
Topics: Adolescent; Adult; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Fema | 1991 |
Valproate-induced lethal hyperammonaemic coma in a carrier of ornithine carbamoyltransferase deficiency.
Topics: Ammonia; Child, Preschool; Coma; Epilepsy; Female; Heterozygote; Humans; Ornithine Carbamoyltransfer | 1991 |
[Evaluation of the effectiveness of monotherapy in the treatment of epilepsy].
Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Drug Evaluation; Epilepsy; Humans; Middle Aged; Pheno | 1991 |
Single dose and steady state pharmacokinetics of valproic acid in adult epileptic patients.
Topics: Administration, Oral; Adult; Anticonvulsants; Epilepsy; Female; Humans; Male; Middle Aged; Valproic | 1991 |
Intrathecal antiepileptic drugs in experimental epilepsy.
Topics: Animals; Anticonvulsants; Catheters, Indwelling; Disease Models, Animal; Dose-Response Relationship, | 1991 |
[The problems of valproate therapy in severely handicapped children--valproate induced hyperammonemia and hypocarnitinemia].
Topics: Adolescent; Adult; Ammonia; Carnitine; Child; Child, Preschool; Disabled Persons; Enteral Nutrition; | 1991 |
Common epileptic syndromes in children.
Topics: Adolescent; Adrenocorticotropic Hormone; Carbamazepine; Child; Child, Preschool; Electroencephalogra | 1991 |
Sodium valproate in pregnancy.
Topics: Epilepsy; Female; Fetal Diseases; Humans; Neural Tube Defects; Pregnancy; Pregnancy Complications; V | 1991 |
[Appropriate dosage for maintaining effective serum level at night after taking one dose of magnesium valproate with separate measurements of serum Mg++ concentration].
Topics: Anticonvulsants; Drug Administration Schedule; Epilepsy; Humans; Magnesium; Valproic Acid | 1991 |
Plasma uric acid in patients receiving anticonvulsant monotherapy.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Phenobarbital; Phenytoin; Prosp | 1991 |
The effect of valproic acid on plasma carnitine levels.
Topics: Adolescent; Anticonvulsants; Carnitine; Child; Child, Preschool; Dose-Response Relationship, Drug; D | 1991 |
[Effects of antiepileptic drugs on delivery and early childhood--comparison among mono-therapies of valproic acid, phenytoin, carbamazepine and phenobarbital].
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Birth Weight; Carbamazepine; Embryonic and Feta | 1991 |
[Sialadenosis caused by long-term valproate medication].
Topics: Adult; Dose-Response Relationship, Drug; Epilepsy; Humans; Male; Parotid Diseases; Parotid Gland; Sa | 1991 |
Sodium valproate-induced menstrual disturbance in young women.
Topics: Adolescent; Amenorrhea; Epilepsy; Female; Gonadotropin-Releasing Hormone; Humans; Luteinizing Hormon | 1991 |
Antiepileptogenic effects of conventional anticonvulsants in the kindling model of epilespy.
Topics: Action Potentials; Analysis of Variance; Animals; Anticonvulsants; Carbamazepine; Epilepsy; Kindling | 1991 |
Ammonia and carnitine concentrations in children treated with sodium valproate compared with other anticonvulsant drugs.
Topics: Adolescent; Ammonia; Anticonvulsants; Carnitine; Child; Child, Preschool; Epilepsy; Erythrocytes; Fe | 1991 |
Pharmacokinetics of total and free valproic acid during monotherapy in infants.
Topics: Blood Proteins; Epilepsy; Female; Half-Life; Humans; Infant; Male; Valproic Acid | 1991 |
Use of antiepileptic drugs in childhood epilepsy.
Topics: Adult; Aminocaproates; Anticonvulsants; Chemical and Drug Induced Liver Injury; Child; Child, Presch | 1991 |
Epileptic patients refractory to drug therapy.
Topics: Adult; Carbamazepine; Epilepsy; Female; Humans; Immunoglobulin G; Immunoglobulins; Male; Middle Aged | 1991 |
Late low magnesium-induced epileptiform activity in rat entorhinal cortex slices becomes insensitive to the anticonvulsant valproic acid.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Electrophysiology; Epilepsy; Hippocampus; In | 1990 |
Seizures: introduction and commentary.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Humans; Phenobarbital; Phenytoin; Valpr | 1991 |
Muscle carnitine deficiency in patients using valproic acid.
Topics: Carnitine; Child, Preschool; Epilepsy; Humans; Infant; Muscles; Valproic Acid | 1991 |
Effects of carbamazepine and valproate on immunological assessment in young epileptic patients.
Topics: Adolescent; Carbamazepine; Epilepsy; Female; Humans; Immunoglobulins; Lymphocyte Subsets; Male; Refe | 1991 |
Nomogram for the prediction of unbound phenytoin concentrations in patients on a combined treatment of phenytoin and valproic acid.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Chromatography, Gas; Chromatogr | 1991 |
PIVKA-II (protein induced by vitamin K absence-II) status in newborns exposed to anticonvulsant drugs in utero.
Topics: Adult; Anticonvulsants; Biomarkers; Diazepam; Epilepsy; Factor VII; Factor X; Female; Humans; Infant | 1991 |
Serum lipids, lipoproteins and apolipoproteins A and B in epileptic patients treated with valproic acid, carbamazepine or phenobarbital.
Topics: Adolescent; Adult; Analysis of Variance; Apolipoproteins A; Apolipoproteins B; Carbamazepine; Child; | 1991 |
Total and free valproic acid: plasma level/dose ratio in monotherapy.
Topics: Adolescent; Adult; Aged; Aging; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsy; | 1991 |
Effects of acute valproic acid administration on carnitine plasma concentrations in epileptic patients.
Topics: Adult; Ammonia; Carnitine; Epilepsy; Humans; Phenobarbital; Phenytoin; Valproic Acid | 1991 |
[Pellagra in anticonvulsive therapy].
Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Ethosuximide; Female; Humans; Intellect | 1990 |
Hyperaminoacidemia in epileptic children treated with valproic acid.
Topics: Adolescent; Amino Acids; Ammonia; Child; Child, Preschool; Epilepsy; Humans; Infant; Valproic Acid | 1990 |
The effects of phenytoin and carbamazepine on serum concentrations of mono-unsaturated metabolites of valproic acid.
Topics: Adult; Aged; Biotransformation; Carbamazepine; Drug Interactions; Epilepsy; Female; Humans; Male; Mi | 1990 |
The effect of valproic acid on SCE and chromosome aberrations in epileptic children.
Topics: Adolescent; Child; Child, Preschool; Chromosome Aberrations; Dose-Response Relationship, Drug; Epile | 1990 |
L-carnitine replacement therapy in chronic valproate treatment.
Topics: Adolescent; Carnitine; Child; Chronic Disease; Epilepsy; Female; Humans; Ketone Bodies; Lipid Metabo | 1990 |
Fluctuations of unbound and total phenytoin concentrations during the day in epileptic patients on valproic acid comedication.
Topics: Adolescent; Adult; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Middle Aged; Phen | 1990 |
Anticonvulsant therapy increases fentanyl requirements during anaesthesia for craniotomy.
Topics: Adolescent; Adult; Anesthesia, Intravenous; Anticonvulsants; Carbamazepine; Craniotomy; Drug Interac | 1990 |
Pilot study to determine the interaction of oxiracetam with antiepileptic drugs.
Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbamazepine; Clob | 1990 |
Eyelid twitching seizures and generalized tonic-clonic convulsions: a syndrome of idiopathic generalized epilepsy.
Topics: Acetazolamide; Adult; Epilepsy; Eyelid Diseases; Female; Humans; Phenytoin; Spasm; Valproic Acid | 1990 |
Cognitive effects of valproate.
Topics: Adult; Anticonvulsants; Cognition; Epilepsy; Female; Humans; Male; Neuropsychological Tests; Psychom | 1990 |
[Incidence of pathologic ammonia concentrations in the plasma in children with seizure disorders treated with Convulsofin/Convulex and other anticonvulsants in comparison with children with brain damage and healthy children].
Topics: Adolescent; Ammonia; Anticonvulsants; Brain Damage, Chronic; Chemical and Drug Induced Liver Injury; | 1990 |
Valproic acid-induced carbamazepine-10,11-epoxide toxicity in children and adolescents.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Interactions; Epile | 1990 |
Carbamazepine metabolism in humans: effect of concurrent anticonvulsant therapy.
Topics: Administration, Oral; Adolescent; Adult; Carbamazepine; Chromatography, High Pressure Liquid; Drug I | 1990 |
Inhibition of epoxide hydrolase by valproic acid in epileptic patients receiving carbamazepine.
Topics: Adolescent; Blood Proteins; Carbamazepine; Child; Epilepsy; Epoxide Hydrolases; Female; Humans; Male | 1990 |
The effect of valproic acid on sister chromatid exchange aberration frequency in epileptic children.
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Humans; Infant; Sister Chromatid Exchange; Valproic A | 1990 |
Valproate-induced hepatoxicity: protective effect of L-carnitine supplementation.
Topics: Anticonvulsants; Carnitine; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Dose-Re | 1990 |
Treatment of epilepsy in people with multiple handicap.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Disabled Persons; Epilepsy; Hum | 1990 |
Antiepileptic medications.
Topics: Anticonvulsants; Barbiturates; Carbamazepine; Dental Care for Disabled; Epilepsy; Humans; Hydantoins | 1990 |
Neocerebellar hypoplasia in a neonate following intra-uterine exposure to anticonvulsants.
Topics: Abnormalities, Drug-Induced; Cerebellum; Drug Therapy, Combination; Epilepsy; Female; Humans; Nerve | 1990 |
[Blood level profile of valproate administration under therapeutic conditions in children].
Topics: Adolescent; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Therapy, Combination; Ep | 1990 |
Valproic acid-associated encephalopathy.
Topics: Epilepsy; Female; Humans; Middle Aged; Valproic Acid | 1990 |
Cognitive effects of long-term treatment with phenobarbital and valproic acid in school children.
Topics: Child; Epilepsy; Female; Follow-Up Studies; Humans; Intelligence; Learning Disabilities; Male; Pheno | 1990 |
[Inequality of bioavailability in commercial tablets of valproic acid].
Topics: Adolescent; Adult; Biological Availability; Child; Circadian Rhythm; Epilepsy; Female; Humans; Male; | 1990 |
Pattern-reversal visual evoked potentials recorded in children with generalized epilepsy.
Topics: Adolescent; Analysis of Variance; Anticonvulsants; Carbamazepine; Child; Epilepsy; Evoked Potentials | 1990 |
Rapid anti-epileptic drug assay.
Topics: Anticonvulsants; Carbamazepine; Child; Dose-Response Relationship, Drug; Epilepsy; Ethosuximide; Hum | 1990 |
[Computerized analysis of EEG background activity in mono-therapeutic patients with epilepsy--relationships between antiepileptic drugs and types of seizures].
Topics: Adult; Anticonvulsants; Brain Mapping; Carbamazepine; Electroencephalography; Epilepsy; Female; Huma | 1990 |
Effects of age and antiepileptic drugs on plasma levels and kinetics of clobazam and N-desmethylclobazam.
Topics: Adolescent; Adult; Age Factors; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepin | 1990 |
Postmortem serum protein binding and brain concentrations of antiepileptic drugs in autoptic specimens from 45 epileptic patients.
Topics: Anticonvulsants; Blood Proteins; Brain; Carbamazepine; Epilepsy; Female; Humans; Male; Phenobarbital | 1990 |
[A clinicopharmacological study of serum sodium valproate free level in children with epilepsy].
Topics: Adolescent; Adult; Age Factors; Blood Proteins; Child; Child, Preschool; Circadian Rhythm; Epilepsy; | 1990 |
Comparative experimental study of antiepileptics--regional specificity of antiepileptic action of carbamazepine, phenobarbital and valproate sodium.
Topics: Animals; Anticonvulsants; Carbamazepine; Epilepsy; Hippocampus; Male; Motor Cortex; Phenobarbital; R | 1990 |
Cognitive function in adult epileptic patients established on anticonvulsant monotherapy.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Cognition; Epilepsy; Female; Humans; Intelligence | 1990 |
[Case of epilepsy in an infant with fatal outcome during the 1st year of unknown etiology].
Topics: Developmental Disabilities; Drug Resistance; Electroencephalography; Epilepsy; Humans; Infant; Infan | 1985 |
Valproic acid and phenytoin effects on serum proteins and immunoglobulins of epileptic patients.
Topics: Adolescent; Adult; Aged; Alpha-Globulins; Beta-Globulins; Blood Proteins; Child; Child, Preschool; E | 1985 |
EEG characteristics of epileptic pattern sensitivity and their relation to the nature of pattern stimulation and the effects of sodium valproate.
Topics: Adolescent; Adult; Child; Dose-Response Relationship, Drug; Electroencephalography; Epilepsy; Female | 1986 |
Side-effects of sodium valproate, mainly related to its hepatic and pancreatic toxicity.
Topics: Adolescent; Adult; Aged; Amylases; Body Weight; Chemical and Drug Induced Liver Injury; Child; Child | 1986 |
The action of valproate on spontaneous epileptiform activity in the absence of synaptic transmission and on evoked changes in [Ca2+]o and [K+]o in the hippocampal slice.
Topics: Animals; Calcium; Cell Membrane Permeability; Electric Stimulation; Epilepsy; Hippocampus; In Vitro | 1986 |
The effects of carbamazepine and sodium valproate on SEPs and BAEPs.
Topics: Adult; Aged; Brain Stem; Carbamazepine; Epilepsy; Evoked Potentials, Auditory; Evoked Potentials, So | 1987 |
Drugs for epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Drug Interactions; Epilepsy; Humans; Phenytoin; Valpro | 1989 |
Pharmacokinetics of valproate in adults after a single loading dose.
Topics: Administration, Oral; Administration, Rectal; Adult; Epilepsy; Humans; Valproic Acid | 1989 |
[The first case of a child born with fetal valproic acid syndrome in Hungary].
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Maternal-Fe | 1989 |
Serum aspirin-esterase activity in epileptic patients receiving treatment with phenobarbital, phenytoin, carbamazepine and valproic acid.
Topics: Adult; Anticonvulsants; Aspirin; Carbamazepine; Epilepsy; Esterases; Female; Humans; Male; Phenobarb | 1989 |
Urinary excretion of valproate and some metabolites in chronically treated patients.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Epilepsy; Female; Humans; Hydroxylation; Male; Mid | 1989 |
Derivation and evaluation of an equation for prediction of free phenytoin concentration in patients co-medicated with valproic acid.
Topics: Adult; Aged; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Mathematics; Middle Aged; Ph | 1989 |
The prevalence of adverse reactions to anticonvulsants in children with epilepsy.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Clonazepam; Drug Therapy, Combi | 1989 |
Valproic acid disposition and protein binding in pregnancy.
Topics: Adult; Epilepsy; Female; Fetal Blood; Gestational Age; Humans; Pregnancy; Protein Binding; Valproic | 1989 |
[Medical treatment of epilepsy].
Topics: Aminocaproates; Anticonvulsants; Carbamazepine; Epilepsy; Humans; Oxcarbazepine; Valproic Acid; Viga | 1989 |
Protoporphyrinaemia and decreased activities of 5-aminolevulinic acid dehydrase and uroporphyrinogen I synthetase in erythrocytes of a Vitamin B6-deficient epileptic boy given valproic acid and carbamazepine.
Topics: Ammonia-Lyases; Carbamazepine; Chromatography, Ion Exchange; Epilepsy; Erythrocytes; Folic Acid; Hum | 1989 |
Effect of phenytoin, carbamazepine, and valproic acid on caffeine metabolism.
Topics: Adolescent; Adult; Aged; Antipyrine; Caffeine; Carbamazepine; Cytochrome P-450 Enzyme System; Enzyme | 1989 |
[Reye syndrome treated with valproic acid in association with varicella infection].
Topics: Adult; Aspirin; Carbamazepine; Chickenpox; Drug Therapy, Combination; Epilepsy; Humans; Male; Reye S | 1989 |
Thyroid hormone concentrations in epileptic patients.
Topics: Anticonvulsants; Carbamazepine; Drug Combinations; Epilepsy; Humans; Phenytoin; Thyrotropin; Thyroxi | 1989 |
[Transient Parkinson syndrome and tremor caused by the use of sodium valproate].
Topics: Aged; Epilepsy; Female; Humans; Male; Middle Aged; Parkinson Disease, Secondary; Valproic Acid | 1989 |
[Advantages of a single daily dose of sodium valproate in the child].
Topics: Adolescent; Child; Child, Preschool; Drug Administration Schedule; Epilepsies, Myoclonic; Epilepsy; | 1989 |
Valproate for epilepsy in renal transplant recipients receiving cyclosporine.
Topics: Adult; Chemical and Drug Induced Liver Injury; Cyclosporins; Epilepsy; Female; Humans; Kidney Transp | 1989 |
Valproate prevents the recurrence of absence status.
Topics: Adolescent; Adult; Aged; Epilepsy; Epilepsy, Absence; Female; Follow-Up Studies; Humans; Male; Middl | 1989 |
The effect of concurrent administration of sodium valproate on serum levels of primidone and its metabolite phenobarbital.
Topics: Adolescent; Adult; Child; Child, Preschool; Drug Interactions; Drug Therapy, Combination; Epilepsy; | 1989 |
Improvement in cognitive functioning and mood state after conversion to valproate monotherapy.
Topics: Affect; Anticonvulsants; Cognition; Epilepsy; Humans; Neuropsychological Tests; Valproic Acid | 1989 |
Epilepsy in women of childbearing age.
Topics: Abnormalities, Drug-Induced; Adult; Carbamazepine; Epilepsy; Female; Humans; Pregnancy; Pregnancy Co | 1989 |
[Valproate induced fetopathy and somatic and psychomotor development].
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Fetal Diseases; Humans; Maternal-Fetal Exchange; Preg | 1989 |
Valproate and spina bifida.
Topics: Adult; Epilepsy; Female; Humans; Maternal-Fetal Exchange; Pregnancy; Pregnancy Complications; Spina | 1989 |
Serum free levels and evaluation anticonvulsant drug interactions.
Topics: Adult; Anticonvulsants; Drug Interactions; Epilepsy; Humans; Male; Phenobarbital; Phenytoin; Valproi | 1989 |
[Factors influencing the effectiveness of preventive treatment of febrile convulsions].
Topics: Anticonvulsants; Child; Drug Evaluation; Epilepsy; Female; Fever; Humans; Male; Phenobarbital; Primi | 1989 |
Probable pseudocholinesterase induction by valproic acid, carbamazepine and phenytoin leading to increased serum aspirin-esterase activity in epileptics.
Topics: Adolescent; Adult; Analysis of Variance; Carbamazepine; Carboxylic Ester Hydrolases; Cholinesterases | 1989 |
Sustained attention during the interictal period of mentally normal children with epilepsy or febrile convulsions, and the influence of anticonvulsants and seizures on attention.
Topics: Anticonvulsants; Attention; Carbamazepine; Child; Drug Therapy, Combination; Epilepsies, Partial; Ep | 1989 |
Cardiazol-induced seizures and the concentration of lipid peroxides in the brain of rats under the influence of valproic acid and vitamin E.
Topics: Animals; Anticonvulsants; Antioxidants; Cerebral Cortex; Convulsants; Drug Therapy, Combination; Epi | 1989 |
Effects of anticonvulsants on spontaneous epileptiform activity which develops in the absence of chemical synaptic transmission in hippocampal slices.
Topics: Animals; Anticonvulsants; Benzodiazepines; Carbamazepine; Cell Membrane Permeability; Epilepsy; Hipp | 1985 |
Dynamic aspects in transient hyperphosphatasaemia of infancy.
Topics: Adenoviridae Infections; Alkaline Phosphatase; Epilepsy; Half-Life; Humans; Infant; Male; Valproic A | 1988 |
Neuroendocrine effects of chronic administration of sodium valproate in epileptic patients.
Topics: Adolescent; Adrenocorticotropic Hormone; Child; Epilepsy; Female; Growth Hormone; Growth Hormone-Rel | 1988 |
Paradoxical enhancement of seizures in the gerbil after chronic treatment with sodium valproate.
Topics: Animals; Epilepsy; Gerbillinae; Receptors, GABA-A; Valproic Acid | 1988 |
Valpromide/carbamazepine and risk of teratogenicity.
Topics: Abnormalities, Drug-Induced; Animals; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Hu | 1985 |
In-utero exposure to valproate and neural tube defects.
Topics: Anticonvulsants; Epilepsy; Female; Fetus; Humans; Infant, Newborn; Maternal-Fetal Exchange; Neural T | 1986 |
Fatal liver failure in children on valproate.
Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Epilepsy; German | 1986 |
Isoniazid-induced valproic-acid toxicity, or vice versa.
Topics: Adolescent; Drug Interactions; Epilepsy; Female; Humans; Isoniazid; Tuberculosis; Valproic Acid | 1987 |
Sodium valproate, pregnancy, and infantile fatal liver failure.
Topics: Acute Disease; Chemical and Drug Induced Liver Injury; Epilepsy; Female; Humans; Infant; Infant, New | 1987 |
Gastritis with valproate therapy.
Topics: Adolescent; Antacids; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; | 1988 |
Valproate, spina bifida, and birth defect registries.
Topics: Abnormalities, Drug-Induced; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complications; Registrie | 1988 |
Influence of valproate and carbamazepine on symmetrical cortical penicillin foci in the rat.
Topics: Animals; Carbamazepine; Dose-Response Relationship, Drug; Electrocardiography; Epilepsy; Male; Penic | 1985 |
Valproate-associated hyperammonemia and DL-carnitine supplement.
Topics: Adolescent; Adult; Ammonia; Carbamazepine; Carnitine; Child; Child, Preschool; Disabled Persons; Dru | 1987 |
[Treatment of epilepsy. Superiority of a single daily dose of sodium valproate over fractionated doses].
Topics: Adolescent; Adult; Child; Drug Administration Schedule; Epilepsy; Humans; Valproic Acid | 1988 |
[Sudden death in epileptics treated with valproic acid].
Topics: Adult; Autopsy; Death, Sudden; Drug Overdose; Epilepsy; Female; Humans; Male; Valproic Acid | 1985 |
Prenatal detection of a neural tube defect after fetal exposure to valproic acid.
Topics: Abortion, Therapeutic; Adolescent; Epilepsy; Female; Fetal Diseases; Humans; Hydrocephalus; Meningom | 1986 |
Valproic acid in the treatment of epilepsy during the pediatric age.
Topics: Adolescent; Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Follow-Up Studies; Hu | 1986 |
Carbamazepine, phenytoin and sodium valproate monotherapy.
Topics: Carbamazepine; Epilepsy; Humans; Phenytoin; Valproic Acid | 1986 |
Sodium valproate monotherapy in childhood epilepsy.
Topics: Adolescent; Adult; Body Weight; Child; Child, Preschool; Electroencephalography; Epilepsies, Myoclon | 1986 |
[Visual evoked potentials in photosensitive epilepsy--effect of valproic acid therapy].
Topics: Adolescent; Epilepsy; Female; Humans; Light; Valproic Acid | 1986 |
Fetal growth, major malformations, and minor anomalies in infants born to women receiving valproic acid.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Epilepsy; Female; Fetus; Growth; Humans; Infant, New | 1986 |
Sodium valproate in epilepsy treatment.
Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy; Humans; Valproic Acid | 1986 |
Development of tolerance to the anticonvulsant effect of GABAmimetic drugs in genetically epilepsy-prone gerbils.
Topics: Acetates; Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Diazepam; D | 1986 |
[Possible uses of Convulsofin liquid in the treatment of pediatric epilepsies].
Topics: Administration, Oral; Adolescent; Child; Child, Preschool; Epilepsies, Myoclonic; Epilepsies, Partia | 1986 |
Renal handling of carnitine in children with carnitine deficiency and hyperammonemia associated with valproate therapy.
Topics: Ammonia; Carnitine; Epilepsy; Humans; Infant; Intellectual Disability; Kidney; Metabolic Clearance R | 1986 |
Behavioral toxicity of chronic ethosuximide and sodium valproate treatment in the epileptic baboon, Papio papio.
Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Epilepsy; Ethosuximide; Female; Ma | 1986 |
[Hyperammonemia in valproate therapy in children and adolescents].
Topics: Adolescent; Ammonia; Anticonvulsants; Child; Drug Therapy, Combination; Epilepsy; Female; Humans; Ma | 1986 |
Phenylethylmalonamide serum levels in patients treated with primidone and the effects of other antiepileptic drugs.
Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Humans; Malonates; Phenobarbita | 1986 |
[Hyperammonemia during sodium valproate therapy: clinically relevant or accidental finding?].
Topics: Adult; Aged; Ammonia; Epilepsy; Female; Humans; Male; Middle Aged; Valproic Acid | 1986 |
[Valproic acid, curly hair and weight gain].
Topics: Adult; Body Weight; Epilepsy; Female; Hair; Humans; Valproic Acid | 1986 |
Drugs for epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Drug Interactions; Epilepsy; Humans; Phenytoin; Status | 1986 |
A comparative study of the relative influence of different anticonvulsant drugs, UV exposure and diet on vitamin D and calcium metabolism in out-patients with epilepsy.
Topics: Adult; Calcium; Carbamazepine; Diet; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin; Ultra | 1986 |
[Various matters concerning the improvement of therapeutic tactics in epilepsy].
Topics: Adolescent; Adult; Anticonvulsants; Barbiturates; Benzodiazepines; Carbamazepine; Drug Therapy, Comb | 1986 |
[Abnormal 13C-palmitate breath test in epileptic patients treated with valproic acid].
Topics: Adolescent; Age Factors; Breath Tests; Carbon Isotopes; Child; Epilepsy; Fatty Acids; Female; Humans | 1986 |
[Determination of N-Dipropylacetamide serum concentration and its clinical significance in epileptic children].
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Valproic Acid | 1986 |
Memory disturbances in epileptic patients.
Topics: Carbamazepine; Drug Therapy, Combination; Epilepsy; Humans; Memory Disorders; Phenytoin; Valproic Ac | 1986 |
Synergistic effects of oxiracetam and piracetam in combination with antiepileptic drugs.
Topics: Animals; Anticonvulsants; Carbamazepine; Clonazepam; Drug Synergism; Drug Therapy, Combination; Epil | 1986 |
Effect of valproic acid therapy on zinc metabolism in children with primary epilepsy.
Topics: Adolescent; Adult; Child; Child, Preschool; Copper; Epilepsy; Erythrocytes; Female; Humans; Male; Mi | 1987 |
Effects of coadministered antiepileptic drugs on free fractions of phenobarbital and valproic acid in epileptic children.
Topics: Anticonvulsants; Child; Drug Therapy, Combination; Epilepsy; Humans; Phenobarbital; Serum Albumin; V | 1986 |
[Epilepsy with continuous discharges during slow-wave sleep. Treatment with clobazam].
Topics: Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Carbamazepine; Child; Child, Preschool; Clo | 1986 |
Forced normalization. Acute psychosis after seizure control in seven patients.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Haloperidol; Humans; Male; Psychotic Disord | 1987 |
Clinically significant danazol-carbamazepine interaction.
Topics: Adult; Carbamazepine; Danazol; Drug Interactions; Epilepsy; Female; Fibrocystic Breast Disease; Huma | 1987 |
Long-term treatment with sodium valproate: monitoring of venous ammonia concentrations and adverse effects.
Topics: Adolescent; Adult; Alopecia; Ammonia; Body Weight; Child; Epilepsy; Female; Gastrointestinal Disease | 1987 |
[Modification of psychophysical performance of the human by anticonvulsants].
Topics: Anticonvulsants; Arousal; Carbamazepine; Diazepam; Epilepsy; Ethosuximide; Humans; Mental Processes; | 1987 |
Valproate for epilepsy in renal transplant recipients receiving cyclosporine.
Topics: Adult; Cyclosporins; Drug Interactions; Epilepsy; Female; Humans; Kidney Transplantation; Valproic A | 1987 |
Barbiturate-refractory epilepsy: safe schedule for therapeutic substitution.
Topics: Adolescent; Adult; Anticonvulsants; Barbiturates; Carbamazepine; Drug Tolerance; Epilepsy; Female; H | 1986 |
Valproic acid loading during intensive monitoring.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Humans; Male; Monitoring, Physiologic; Substan | 1987 |
Prescribing in pregnancy.
Topics: Epilepsy; Female; Humans; Neural Tube Defects; Pregnancy; Pregnancy Complications; Valproic Acid | 1987 |
Status epilepticus within the Lennox-Gastaut syndrome: clinical characteristics and management.
Topics: Child; Clonazepam; Electroencephalography; Epilepsy; Humans; Male; Status Epilepticus; Syndrome; Val | 1987 |
Blood ammonia level during valproic acid therapy.
Topics: Adolescent; Adult; Ammonia; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Female; Hu | 1986 |
[Side effects of valproate in epileptic children].
Topics: Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Long-Term Care; Male; Valproi | 1987 |
A suspected case of late-onset sodium-valproate-induced hepatic failure.
Topics: Adolescent; Drug Therapy, Combination; Epilepsy; Hepatic Encephalopathy; Humans; Liver; Male; Valpro | 1987 |
Anticonvulsant drugs in monotherapy. Effect on the fetus.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fe | 1987 |
[Significance of the determination of valproate levels in the blood].
Topics: Adult; Epilepsy; Female; Humans; Male; Valproic Acid | 1987 |
Bioavailability of sodium valproate suppositories during repeated administration at steady state in epileptic children.
Topics: Administration, Oral; Adolescent; Biological Availability; Child; Child, Preschool; Epilepsy; Female | 1987 |
Determination of valproic acid and its metabolites by gas chromatography-mass spectrometry with selected ion monitoring.
Topics: Adolescent; Adult; Biotransformation; Child; Child, Preschool; Drug Stability; Epilepsy; Female; Gas | 1987 |
[Cognitive effects of antiepileptic drugs].
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cognition Disorders; Epilepsy; | 1987 |
Serum valproate concentrations in epileptic children with favourable responses.
Topics: Adolescent; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsies, Partial; Epilepsy | 1987 |
[Study, in mice, of the influence of intestinal parasitic disease on the antiepileptic effects of sodium valproate].
Topics: Animals; Anticonvulsants; Epilepsy; Male; Mice; Oxyuriasis; Pyrantel Pamoate; Valproic Acid | 1987 |
The management of epilepsy in women of child-bearing age and the Australian experience of valproate in pregnancy.
Topics: Abnormalities, Drug-Induced; Australia; Epilepsy; Female; Humans; Infant, Newborn; Pregnancy; Pregna | 1987 |
Bidirectional effects of beta-carbolines in reflex epilepsy.
Topics: Animals; Anticonvulsants; Brain; Carbolines; Epilepsy; Female; gamma-Aminobutyric Acid; Male; Mice; | 1987 |
[Valproic acid monotherapy in epilepsies in childhood and adolescence].
Topics: Adolescent; Child; Child, Preschool; Electroencephalography; Epilepsies, Partial; Epilepsy; Evoked P | 1987 |
[Effects of sodium valproate on amino acid concentrations in serum and urine].
Topics: Adolescent; Adult; Amino Acids; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Val | 1987 |
Divalproex/valproate monotherapy: an international perspective. Proceedings of a symposium held in conjunction with the 1986 American Epilepsy Society meeting, Seattle, Washington.
Topics: Epilepsy; Humans; Valproic Acid | 1987 |
Effect of chronic valproic acid treatment on plasma and urine carnitine levels in children: decreased urinary excretion.
Topics: Adolescent; Carnitine; Child; Epilepsy; Humans; Male; Valproic Acid | 1987 |
[Side effects of valproic acid therapy in adulthood].
Topics: alpha-Amylases; Drug Therapy, Combination; Epilepsy; Female; Humans; Leukopenia; Liver Function Test | 1988 |
Treatment of childhood epilepsy with rectal valproate: case reports and pharmacokinetic study.
Topics: Administration, Rectal; Epilepsy; Female; Humans; Infant; Male; Valproic Acid | 1987 |
An interaction between cytostatic and anticonvulsant drugs.
Topics: Adenocarcinoma, Papillary; Adult; Altretamine; Antineoplastic Combined Chemotherapy Protocols; Carba | 1988 |
The effective evaluation of thyroid status in patients on phenytoin, carbamazepine or sodium valproate attending an epilepsy clinic.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Male; Midd | 1987 |
Plasma concentrations of unbound valproate and the management of epilepsy.
Topics: Adolescent; Adult; Epilepsy; Female; Humans; Male; Middle Aged; Protein Binding; Valproic Acid | 1987 |
Is valproate monotherapy a practical possibility in chronically uncontrolled epilepsy?
Topics: Anticonvulsants; Drug Therapy, Combination; Epilepsy; Female; Humans; Male; Valproic Acid | 1988 |
Mono-unsaturated metabolites of valproic acid in epileptic women and their neonates.
Topics: Adult; Epilepsy; Female; Fetus; Humans; Infant, Newborn; Maternal-Fetal Exchange; Placenta; Pregnanc | 1987 |
Computerized EEG analysis of penicillin induced seizure threshold in developing rats.
Topics: Aging; Animals; Computers; Disease Models, Animal; Electroencephalography; Epilepsy; Penicillins; Ra | 1987 |
[Etiologic factors in epilepsy as a predictor of response to anticonvulsive drug therapy].
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Therapy, Combination; Elec | 1988 |
Delayed bone development in epileptic children assessed by microdensitometer.
Topics: Adolescent; Anticonvulsants; Bone Development; Calcifediol; Calcitriol; Child; Child, Preschool; Den | 1988 |
Zinc concentrations in leucocytes of patients receiving antiepileptic drugs.
Topics: Adult; Carbamazepine; Epilepsy; Female; Humans; Male; Neutrophils; Valproic Acid; Zinc | 1988 |
Effect of food on the serum concentration profile of enteric-coated valproic acid.
Topics: Adult; Eating; Epilepsy; Female; Humans; Male; Middle Aged; Tablets, Enteric-Coated; Valproic Acid | 1988 |
[Effectiveness and tolerance of valproic acid monotherapy in patients with epilepsy].
Topics: Adolescent; Adult; Anticonvulsants; Child; Drug Therapy, Combination; Epilepsy; Female; Follow-Up St | 1988 |
Kawasaki-like syndrome caused by carbamazepine.
Topics: Carbamazepine; Child, Preschool; Drug Hypersensitivity; Epilepsy; Humans; Male; Mucocutaneous Lymph | 1988 |
A comparative study of the relative effects of anticonvulsant drugs and dietary folate on the red cell folate status of patients with epilepsy.
Topics: Adult; Anticonvulsants; Carbamazepine; Diet; Drug Therapy, Combination; Epilepsy; Erythrocytes; Fema | 1987 |
Abnormal 13C-fatty acid breath tests in patients treated with valproic acid.
Topics: Adolescent; Caprylates; Child; Child, Preschool; Dose-Response Relationship, Drug; Epilepsy; Fatty A | 1988 |
Combination of valproate and ethosuximide: antiepileptic and neurotoxic interaction.
Topics: Animals; Brain; Drug Synergism; Drug Therapy, Combination; Epilepsy; Ethosuximide; Female; Mice; Mic | 1988 |
Pharmacokinetics of free and total sodium valproate in adolescents and young adults during maintenance therapy.
Topics: Adolescent; Adult; Anticonvulsants; Blood Proteins; Dose-Response Relationship, Drug; Epilepsy; Fema | 1988 |
Hyperamino-acidaemia and hyperammonaemia in epileptic children treated with valproic acid.
Topics: Adolescent; Amino Acids; Ammonia; Child; Child, Preschool; Epilepsy; Humans; Infant; Valproic Acid | 1988 |
Valproate monotherapy in the treatment of epilepsy.
Topics: Epilepsy; Humans; Valproic Acid | 1988 |
Valproate monotherapy in children.
Topics: Anticonvulsants; Child; Drug Therapy, Combination; Epilepsies, Myoclonic; Epilepsy; Epilepsy, Absenc | 1988 |
Crossover from polytherapy to monotherapy in primary generalized epilepsy.
Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Female; Humans; Valproic Acid | 1988 |
Congenital abnormalities in two sibs exposed to valproic acid in utero.
Topics: Abnormalities, Drug-Induced; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Infan | 1988 |
Sodium valproate.
Topics: Australia; Drug Prescriptions; Epilepsy; Humans; Valproic Acid | 1988 |
Predictability of unbound antiepileptic drug concentrations in children treated with valproic acid and phenytoin.
Topics: Adolescent; Adult; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Phenytoin; Prote | 1988 |
Variability of phenytoin, carbamazepine and valproate concentrations in a clinic population.
Topics: Carbamazepine; Epilepsy; Female; Humans; Male; Minnesota; Outpatient Clinics, Hospital; Patient Comp | 1988 |
[Clinical treatment of resistant epilepsy].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Resistance; Electroencephalography; E | 1988 |
Plasma concentrations of unbound valproate in the management of epilepsy.
Topics: Adult; Epilepsy; Humans; Male; Valproic Acid | 1988 |
Changes in clearance of sodium valproate with changes in dose.
Topics: Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; M | 1987 |
Fluorescence polarization immunoassay and enzyme immunoassay compared for free valproic acid in serum ultrafiltrates from epileptic patients.
Topics: Adult; Autoanalysis; Epilepsy; Female; Fluorescence Polarization; Humans; Immunoassay; Immunoenzyme | 1985 |
Possible valproate teratogenicity.
Topics: Abnormalities, Multiple; Epilepsy; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Neural | 1985 |
Comparison of steady-state pharmacokinetics of valproic acid in children between monotherapy and multiple antiepileptic drug treatment.
Topics: Adolescent; Age Factors; Anticonvulsants; Child; Drug Therapy, Combination; Epilepsy; Female; Half-L | 1985 |
Time-dependent interaction between phenytoin and valproic acid.
Topics: Adolescent; Adult; Child; Child, Preschool; Circadian Rhythm; Drug Interactions; Drug Therapy, Combi | 1985 |
[Acute liver necrosis caused by valproate].
Topics: Adult; Creatine Kinase; Epilepsy; Female; Humans; Liver Cirrhosis; Phenytoin; Transaminases; Valproi | 1985 |
Effects of pregnancy on antiepileptic drug utilization.
Topics: Anticonvulsants; Biological Availability; Carbamazepine; Epilepsy; Female; Humans; Kinetics; Metabol | 1985 |
Adaptation of hepatic ammonia metabolism after chronic valproate administration in epileptics treated with phenytoin.
Topics: Adaptation, Physiological; Adult; Ammonia; Drug Interactions; Drug Therapy, Combination; Epilepsy; H | 1985 |
Sodium valproate "encephalopathy": report of three cases with generalised epilepsy.
Topics: Adult; Arousal; Brain Diseases; Child; Confusion; Electroencephalography; Epilepsy; Female; Humans; | 1985 |
Anticonvulsant drugs and the genetically epilepsy-prone rat.
Topics: Acoustic Stimulation; Amitriptyline; Animals; Anticonvulsants; Carbamazepine; Desipramine; Disease M | 1985 |
Valproic acid toxicity.
Topics: Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Epilepsy; Humans; Infant; Pancreati | 1985 |
The effects of phenytoin and sodium valproate on the periodontal health of adult epileptic patients.
Topics: Adolescent; Adult; Aged; Alveolar Process; Bone Resorption; Cross-Sectional Studies; Dental Plaque I | 1985 |
Pharmacological evaluation of various metabolites and analogues of valproic acid. Anticonvulsant and toxic potencies in mice.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Disease Models, Animal; Epilepsy; Ethosuxim | 1985 |
Drug compliance and seizure control in epileptic children.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Infan | 1985 |
Monotherapy and polytherapy for intractable epilepsies.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbamazepine; Clobazam; D | 1985 |
Sub-normal serum thyroxine levels associated with carbamazepine and valproic acid treatment.
Topics: Carbamazepine; Child; Diabetes Complications; Drug Therapy, Combination; Epilepsy; Humans; Male; Thy | 1985 |
Spectral analysis of the EEG in children during the introduction of antiepileptic therapy with valproic acid.
Topics: Adolescent; Child; Child, Preschool; Electroencephalography; Epilepsy; Epilepsy, Absence; Epilepsy, | 1985 |
Interictal EEG prediction of response to antiepileptic drug monotherapy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Electroencephalogr | 1985 |
Improved direct injection method and extractive methylation method for determination of valproic acid in serum by gas chromatography.
Topics: Chromatography, Gas; Epilepsy; Humans; Methylation; Valproic Acid | 1985 |
Longterm follow-up of childhood epilepsy with absences. I. Epilepsy with absences at onset.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsy; Epilepsy, Absence; Ethosuximi | 1985 |
Evaluation of the effects of antiepileptic drugs on sleep-wakefulness patterns following 1 night total sleep deprivation in epileptic patients.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Epilepsy; Human | 1985 |
[Use of sodium valproate in children].
Topics: Epilepsy; Humans; Infant; Seizures, Febrile; Valproic Acid | 1985 |
Chronic valproic acid therapy and incidence of increases in venous plasma ammonia.
Topics: Adolescent; Adult; Aged; Ammonia; Carbamazepine; Child; Child, Preschool; Drug Interactions; Epileps | 1985 |
[Clinical and electroencephalographic study of the effects of valpramide in treating epilepsy].
Topics: Adolescent; Adult; Anticonvulsants; Child; Electroencephalography; Epilepsy; Female; Humans; Male; M | 1985 |
Valproic acid pharmacokinetics in children. II. Discontinuation of concomitant antiepileptic drug therapy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Interactions; Epilepsy; Female; Humans; M | 1985 |
The optimum use of anticonvulsants.
Topics: Anticonvulsants; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epilepsy; Humans; Phen | 1985 |
Effect of serum albumin on free fractions of phenobarbital and valproic acid in patients with convulsive seizures.
Topics: Adolescent; Adult; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Female; Humans; Inf | 1985 |
Alterations in transient visual-evoked potentials induced by clonazepam and sodium valproate.
Topics: Adolescent; Adult; Benzodiazepinones; Brain; Child; Clonazepam; Epilepsy; Evoked Potentials, Visual; | 1985 |
Where, why, and what type of therapy.
Topics: Carbamazepine; Child; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Hum | 1985 |
Monitoring: the most important role of the pediatrician.
Topics: Activities of Daily Living; Anticonvulsants; Carbamazepine; Child, Preschool; Environmental Monitori | 1985 |
Serum concentrations of valproic acid: influence of dose and comedication.
Topics: Adolescent; Adult; Body Weight; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Epileps | 1985 |
Concentration of valproate during pregnancy, in the newborn and in breast milk.
Topics: Adult; Body Weight; Epilepsy; Female; Fetal Blood; Humans; Kinetics; Maternal-Fetal Exchange; Milk, | 1985 |
[Effects of valproate on mitochondrial function in epileptic patients].
Topics: Adolescent; Ammonia; Carnitine; Child; Child, Preschool; Epilepsy; Humans; Lactates; Lactic Acid; Mi | 1985 |
An improved gas liquid chromatographic assay for plasma valproic acid concentrations in mentally handicapped epileptic children.
Topics: Child; Chromatography, Gas; Epilepsy; Humans; Neurocognitive Disorders; Valproic Acid | 1985 |
Maternal epilepsy and birth defects: a case-control study in the Italian Multicentric Registry of Birth Defects (IPIMC).
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Chromosome Aberrations; Chromosome Disorders; Chromoso | 1985 |
Use of total and free anticonvulsant serum levels in clinical practice.
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Humans; Immunoenzyme Techniques; Phenobarbital; Phenytoin; | 1985 |
Valproate hepatotoxicity: a review and report of two instances in adults.
Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Electroencephalography; Epilepsy; Humans; | 1985 |
Progressive myoclonic epilepsy. The response to sodium di -- n -- propylacetate.
Topics: Adult; Epilepsy; Humans; Male; Myoclonus; Syndrome; Valerates; Valproic Acid | 1974 |