Page last updated: 2024-10-26

valproic acid and Audiogenic Epilepsy

valproic acid has been researched along with Audiogenic Epilepsy in 34 studies

Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.

Research Excerpts

ExcerptRelevanceReference
" The blocking effects of valproate (2-propylpentanoic acid), a standard anti-epileptic drug, on metaphit (1-[1-(3-isothiocyanatophenyl)-cyclohexyl]-piperidine)-induced audiogenic seizures as a model of generalized, reflex audiogenic epilepsy in adult Wistar male rats were studied."3.74Anticonvulsant, but not antiepileptic, action of valproate on audiogenic seizures in metaphit-treated rats. ( Hrncić, DR; Stanojlović, OP; Susić, VT; Zivanović, DP, 2007)
"Our study confirms that photosensitive epilepsy has a good prognosis for seizure control that is independent of the persistence or disappearance of photosensitivity."2.71Photosensitivity and epilepsy: a follow-up study. ( Chiarelli, F; Cutarella, R; di Corcia, G; Latini, G; Salladini, C; Trotta, D; Verrotti, A, 2004)
"Reflex epileptic seizures can often be prevented by avoidance or modification of triggers or by prophylactic benzodiazepine administration."2.53Reflex epileptic mechanisms in ictogenesis and therapeutic consequences. ( Guaranha, M; Lin, K; Wolf, P, 2016)
"Eating-induced seizures are an uncommon presentation of reflex epilepsy, a condition characterized by seizures provoked by specific stimuli."1.36Unilateral opercular lesion and eating-induced seizures. ( Friedman, DE; Kung, DH; Manyam, SC; Newmark, ME; Rhodes, LB, 2010)
"Metaphit-treated rats displaying seizures in 8 previous tests were i."1.33Delta-sleep-inducing peptide potentiates anticonvulsive activity of valproate against metaphit-provoked audiogenic seizure in rats. ( Hrncić, D; Stanojlović, O; Susić, V; Zivanović, D, 2006)
"Reflex myoclonic epilepsy of infancy is an idiopathic epileptic disorder characterized by myoclonic attacks, with onset in the first 2 years of life precipitated exclusively by unexpected tactile or auditory stimuli."1.32Reflex myoclonic epilepsy in infancy: a benign age-dependent idiopathic startle epilepsy. ( Kontopoulos, E; Vargiami, E; Zafeiriou, D, 2003)
"This case of non-progressive reflex myoclonic epilepsy of infancy triggered only by head tapping (and not by acoustic stimuli) is an extremely rare phenomenon."1.32An unusual case of benign reflex myoclonic epilepsy of infancy. ( King, MD; Kurian, MA, 2003)
"A patient suffering from juvenile myoclonic epilepsy experienced myoclonic jerks, fairly regularly, while playing chess."1.32Chess-playing epilepsy: a case report with video-EEG and back averaging. ( Debrand, E; Gueguen, B; Guillou, S; Mann, MW; Soufflet, C, 2004)
"Reflex epilepsy is the commonest form of epilepsy in which seizures are provoked by specific external stimulus."1.31Video game epilepsy. ( Bhalla, A; Lehl, SS; Sachdev, A; Singh, R, 2001)
"Metoprolol was less active and atenolol was unable to affect audiogenic seizures."1.31Influence of some beta-adrenoceptor antagonists on the anticonvulsant potency of antiepileptic drugs against audiogenic seizures in DBA/2 mice. ( De Sarro, A; De Sarro, G; Di Paola, ED; Ferreri, G; Fischer, W, 2002)
" Repeating the EEG after the dosage has been lowered will help avoiding unnecessary recurrence of seizures."1.31[Television, children and epilepsy]. ( Dekker, E; Stroink, H; Trenité, DG, 2002)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's25 (73.53)29.6817
2010's9 (26.47)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Xu, L1
Guo, D1
Liu, YY1
Qiao, DD1
Ye, JY1
Xue, R1
Jabeen, SA1
Chowdary, AH1
Mridula, KR1
Cherian, A1
Kumar, PR1
Sarva, S1
Murty, CV1
Barrera-Bailón, B1
Oliveira, JA1
López, DE1
Muñoz, LJ1
Garcia-Cairasco, N1
Sancho, C1
Verrotti, A3
Grosso, S1
D'Egidio, C1
Parisi, P2
Spalice, A1
Pavone, P1
Capovilla, G2
Agostinelli, S1
Perry, G1
Brindley, LM1
Muthukumaraswamy, SD1
Singh, KD1
Hamandi, K1
Lin, K1
Guaranha, M1
Wolf, P2
Chirchiglia, D1
Torre, AD1
Volpentesta, G1
Lavano, SM1
Lavano, A1
Borzi', G1
Etemadifar, M1
Raoufi, M1
Maghzi, AH1
Ebrahimi, A1
Kaji-Esfahani, M1
Mousavi, SA1
Fiori, F1
Coppola, G1
Franzoni, E1
Chiarelli, F2
Manyam, SC1
Kung, DH1
Rhodes, LB1
Newmark, ME1
Friedman, DE1
Savina, TA3
Shchipakina, TG3
Adachi, M1
Tsuneishi, S1
Nakamura, H1
Shahar, E1
Barak, S1
Zafeiriou, D1
Vargiami, E1
Kontopoulos, E1
Kurian, MA1
King, MD1
Chifari, R1
Piazzini, A1
Turner, K1
Canger, R1
Canevini, MP1
Trotta, D1
Salladini, C1
di Corcia, G1
Latini, G1
Cutarella, R1
Singhi, PD1
Bansal, D1
Anyanwu, EC1
Ehiri, JE1
Campbell, AW1
Burneo, JG1
Miller, S1
Bebin, EM1
Prasad, A1
Mann, MW1
Gueguen, B1
Guillou, S1
Debrand, E1
Soufflet, C1
Watanabe, K1
Sayres, R1
Shimojo, S1
Imada, T1
Nihei, K1
Hrncić, D3
Stanojlović, O3
Zivanović, D2
Susić, V3
Aldenkamp, A1
Vigevano, F1
Arzimanoglou, A1
Covanis, A1
Rasić, A2
Beccaria, F1
Gambardella, A1
Montagnini, A1
Avantaggiato, P1
Seri, S1
Balashova, OA2
Stanojlović, OP1
Hrncić, DR1
Zivanović, DP1
Susić, VT1
Loncar-Stevanović, H1
Djuric, D1
Salas-Puig, J1
Parra, J1
Fernández-Torre, JL1
Singh, R1
Bhalla, A1
Lehl, SS1
Sachdev, A1
De Sarro, G1
Di Paola, ED1
Ferreri, G1
De Sarro, A1
Fischer, W1
Stroink, H1
Dekker, E1
Trenité, DG1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy of New Lenses in Abolishing Photoparoxysmal Responses in Paediatric Patients With Photosensitive Epilepsy (PSE)[NCT04076410]76 participants (Anticipated)Interventional2021-02-20Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for valproic acid and Audiogenic Epilepsy

ArticleYear
Juvenile myoclonic epilepsy and sleep.
    Epilepsy & behavior : E&B, 2018, Volume: 80

    Topics: Adolescent; Adult; Circadian Rhythm; Electroencephalography; Epilepsy, Reflex; Female; Humans; Male;

2018
Reflex epileptic mechanisms in ictogenesis and therapeutic consequences.
    Expert review of neurotherapeutics, 2016, Volume: 16, Issue:5

    Topics: Epilepsies, Partial; Epilepsy; Epilepsy, Reflex; Humans; Seizures; Valproic Acid

2016
[Eyelid myoclonia with absences (EMA)].
    Ryoikibetsu shokogun shirizu, 2002, Issue:37 Pt 6

    Topics: Anticonvulsants; Child; Child, Preschool; Diagnosis, Differential; Electroencephalography; Epilepsie

2002
Self induced photosensitive epilepsy.
    Indian journal of pediatrics, 2004, Volume: 71, Issue:7

    Topics: Anticonvulsants; Child; Electroencephalography; Epilepsy, Reflex; Female; Humans; Photic Stimulation

2004
Role of valproate across the ages. Treatment of epilepsy in children.
    Acta neurologica Scandinavica. Supplementum, 2006, Volume: 184

    Topics: Anticonvulsants; Child; Epilepsies, Myoclonic; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epi

2006
[Photogenic epilepsy].
    Revista de neurologia, 2000, Volume: 30 Suppl 1

    Topics: Adolescent; Adult; Animals; Anticonvulsants; Child; Child, Preschool; Electroencephalography; Epilep

2000

Trials

2 trials available for valproic acid and Audiogenic Epilepsy

ArticleYear
Idiopathic generalized tonic-clonic epilepsy and photosensitivity: a long-term follow-up study.
    Acta paediatrica (Oslo, Norway : 1992), 2009, Volume: 98, Issue:12

    Topics: Adolescent; Anticonvulsants; Chi-Square Distribution; Child; Drug Therapy, Combination; Electroencep

2009
Photosensitivity and epilepsy: a follow-up study.
    Developmental medicine and child neurology, 2004, Volume: 46, Issue:5

    Topics: Adolescent; Anticonvulsants; Chi-Square Distribution; Child; Child, Preschool; Drug Therapy, Combina

2004

Other Studies

26 other studies available for valproic acid and Audiogenic Epilepsy

ArticleYear
Pure graphogenic epilepsy--a rare form of reflex epilepsy.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2013, Volume: 40, Issue:4

    Topics: Anticonvulsants; Electroencephalography; Epilepsy, Reflex; Humans; Magnetic Resonance Imaging; Male;

2013
Pharmacological and neuroethological studies of three antiepileptic drugs in the Genetic Audiogenic Seizure Hamster (GASH:Sal).
    Epilepsy & behavior : E&B, 2013, Volume: 28, Issue:3

    Topics: Acoustic Stimulation; Animals; Anticonvulsants; Behavior, Animal; Chromatography, High Pressure Liqu

2013
Valproate in adolescents with photosensitive epilepsy with generalized tonic-clonic seizures only.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2014, Volume: 18, Issue:1

    Topics: Adolescent; Anticonvulsants; Child; Electroencephalography; Epilepsy, Reflex; Epilepsy, Tonic-Clonic

2014
Evidence for increased visual gamma responses in photosensitive epilepsy.
    Epilepsy research, 2014, Volume: 108, Issue:6

    Topics: Adolescent; Adult; Anticonvulsants; Brain; Child; Epilepsy, Generalized; Epilepsy, Reflex; Evoked Po

2014
Hemiplegic migraine and late-onset photosensitive epileptic seizures.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2016, Volume: 37, Issue:12

    Topics: Adult; Anticonvulsants; Electroencephalography; Epilepsy, Reflex; Female; Glycosides; Humans; Migrai

2016
Television-provoked epilepsy in children: a follow-up survey from Isfahan, Iran.
    Archives of Iranian medicine, 2008, Volume: 11, Issue:6

    Topics: Anticonvulsants; Carbamazepine; Child; Electroencephalography; Epilepsy, Reflex; Female; Follow-Up S

2008
Unilateral opercular lesion and eating-induced seizures.
    Epileptic disorders : international epilepsy journal with videotape, 2010, Volume: 12, Issue:4

    Topics: Anticonvulsants; Brain Neoplasms; Cerebral Cortex; Diagnosis, Differential; Eating; Electroencephalo

2010
cAMP-dependent phosphorylation of microtubule-associated protein-2 during treatment of sodium valproate and audiogenic kindling.
    Bulletin of experimental biology and medicine, 2011, Volume: 152, Issue:1

    Topics: Analysis of Variance; Anticonvulsants; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Acti

2011
Favorable outcome of epileptic blindness in children.
    Journal of child neurology, 2003, Volume: 18, Issue:1

    Topics: Acute Disease; Adolescent; Anticonvulsants; Blindness, Cortical; Carbamazepine; Child; Electroenceph

2003
Reflex myoclonic epilepsy in infancy: a benign age-dependent idiopathic startle epilepsy.
    Epileptic disorders : international epilepsy journal with videotape, 2003, Volume: 5, Issue:2

    Topics: Acoustic Stimulation; Anticonvulsants; Child, Preschool; Electroencephalography; Epilepsies, Myoclon

2003
An unusual case of benign reflex myoclonic epilepsy of infancy.
    Neuropediatrics, 2003, Volume: 34, Issue:3

    Topics: Anticonvulsants; Electroencephalography; Epilepsies, Myoclonic; Epilepsy, Reflex; Humans; Infant; Ma

2003
Reflex writing seizures in two siblings with juvenile myoclonic epilepsy.
    Acta neurologica Scandinavica, 2004, Volume: 109, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Attention; Electroencephalography; Epilepsy, Reflex; Evoked Pote

2004
Efficacy of sodium valproate in the treatment of photosensitive epilepsy (PSE) and the probable reasons for the persistence of occipital spikes.
    TheScientificWorldJournal, 2004, Jul-15, Volume: 4

    Topics: Action Potentials; Adolescent; Adult; Child; Electroencephalography; Epilepsy, Reflex; Evoked Potent

2004
Video-EEG study in an adult and a child with eyelid myoclonia with absences.
    Epileptic disorders : international epilepsy journal with videotape, 2004, Volume: 6, Issue:4

    Topics: Adult; Anticonvulsants; Child; Dominance, Cerebral; Drug Therapy, Combination; Electroencephalograph

2004
Chess-playing epilepsy: a case report with video-EEG and back averaging.
    Epileptic disorders : international epilepsy journal with videotape, 2004, Volume: 6, Issue:4

    Topics: Adult; Anticonvulsants; Attention; Electroencephalography; Electromyography; Epilepsies, Myoclonic;

2004
Effect of sodium valproate on neuromagnetic responses to chromatic flicker: implication for photosensitivity.
    Neurology & clinical neurophysiology : NCN, 2004, Nov-30, Volume: 2004

    Topics: Adolescent; Adult; Color; Epilepsy, Reflex; Female; Flicker Fusion; Humans; Magnetoencephalography;

2004
Delta-sleep-inducing peptide potentiates anticonvulsive activity of valproate against metaphit-provoked audiogenic seizure in rats.
    Pharmacology, 2006, Volume: 77, Issue:2

    Topics: Acoustic Stimulation; Animals; Anticonvulsants; Delta Sleep-Inducing Peptide; Drug Combinations; Epi

2006
Valproate and delta-sleep peptide display high efficacy against metaphit-induced audiogenic seizure in rats.
    Acta physiologica Hungarica, 2006, Volume: 93, Issue:4

    Topics: Animals; Anticonvulsants; Delta Sleep-Inducing Peptide; Dose-Response Relationship, Drug; Electroenc

2006
Photosensitive benign myoclonic epilepsy in infancy.
    Epilepsia, 2007, Volume: 48, Issue:1

    Topics: Age of Onset; Anticonvulsants; Child; Child, Preschool; Comorbidity; Electroencephalography; Epileps

2007
Effect of chronic consumption of sodium valproate and melatonin on seizure activity in Krushinskii-Molodkina rats.
    Bulletin of experimental biology and medicine, 2006, Volume: 142, Issue:5

    Topics: Acoustic Stimulation; Animals; Anticonvulsants; Drug Combinations; Epilepsies, Myoclonic; Epilepsy,

2006
Anticonvulsant, but not antiepileptic, action of valproate on audiogenic seizures in metaphit-treated rats.
    Clinical and experimental pharmacology & physiology, 2007, Volume: 34, Issue:10

    Topics: Acoustic Stimulation; Animals; Anticonvulsants; Behavior, Animal; Data Interpretation, Statistical;

2007
Interaction of Delta sleep-inducing peptide and valproate on metaphit audiogenic seizure model in rats.
    Cellular and molecular neurobiology, 2007, Volume: 27, Issue:7

    Topics: Animals; Anticonvulsants; Delta Sleep-Inducing Peptide; Disease Models, Animal; Drug Synergism; Drug

2007
Ca2+/calmodulin-dependent protein kinase II--a target for sodium valproate?
    Neuroscience and behavioral physiology, 2008, Volume: 38, Issue:1

    Topics: Animals; Anticonvulsants; Brain; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Disease Models,

2008
Video game epilepsy.
    Neurology India, 2001, Volume: 49, Issue:4

    Topics: Adolescent; Anticonvulsants; Child; Epilepsy, Reflex; Humans; Male; Valproic Acid; Video Games

2001
Influence of some beta-adrenoceptor antagonists on the anticonvulsant potency of antiepileptic drugs against audiogenic seizures in DBA/2 mice.
    European journal of pharmacology, 2002, May-10, Volume: 442, Issue:3

    Topics: Acoustic Stimulation; Adrenergic beta-Antagonists; Animals; Anticonvulsants; Atenolol; Body Temperat

2002
[Television, children and epilepsy].
    Nederlands tijdschrift voor geneeskunde, 2002, Jun-08, Volume: 146, Issue:23

    Topics: Adolescent; Adult; Anticonvulsants; Child; Electroencephalography; Epilepsy, Reflex; Female; Humans;

2002