valproic acid has been researched along with Atherogenesis in 15 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the study was to investigate the risk of subclinical atherosclerosis independent from obesity and high blood lipid levels in pediatric patients with idiopathic epilepsy receiving valproic acid or levetiracetam monotherapy by evaluating carotid intima-media thickness (CIMT) and Epicardial adipose tissue thickness (EATT)." | 7.96 | Effects of valproic acid and levetiracetam monotherapy on carotid intima-media and epicardial adipose tissue thickness in non-obese children with epilepsy. ( Karatoprak, E; Tosun, O, 2020) |
| "The participants included 53 epilepsy patients who received either valproic acid (VPA, n=26) or oxcarbazepine (OXC, n=27)." | 7.79 | Assessment of atherosclerosis risk due to the homocysteine-asymmetric dimethylarginine-nitric oxide cascade in children taking antiepileptic drugs. ( Arga, M; Arhan, E; Biberoglu, G; Cansu, A; Emeksiz, HC; Gulbahar, O; Hasanoglu, A; Serdaroglu, A, 2013) |
| "The aim of the study was to investigate the risk of subclinical atherosclerosis independent from obesity and high blood lipid levels in pediatric patients with idiopathic epilepsy receiving valproic acid or levetiracetam monotherapy by evaluating carotid intima-media thickness (CIMT) and Epicardial adipose tissue thickness (EATT)." | 3.96 | Effects of valproic acid and levetiracetam monotherapy on carotid intima-media and epicardial adipose tissue thickness in non-obese children with epilepsy. ( Karatoprak, E; Tosun, O, 2020) |
| "The participants included 53 epilepsy patients who received either valproic acid (VPA, n=26) or oxcarbazepine (OXC, n=27)." | 3.79 | Assessment of atherosclerosis risk due to the homocysteine-asymmetric dimethylarginine-nitric oxide cascade in children taking antiepileptic drugs. ( Arga, M; Arhan, E; Biberoglu, G; Cansu, A; Emeksiz, HC; Gulbahar, O; Hasanoglu, A; Serdaroglu, A, 2013) |
| " Here we examine the temporal relation between the onset of hyperglycemia, glucosamine accumulation in the vessel wall, ER stress, and the development of atherosclerosis." | 3.75 | Evidence supporting a role for endoplasmic reticulum stress in the development of atherosclerosis in a hyperglycaemic mouse model. ( Bowes, AJ; Khan, MI; Pichna, BA; Shi, Y; Werstuck, GH, 2009) |
| "Valproic acid (VPA) has been used to treat epilepsy and bipolar disorder." | 1.72 | Valproic acid decreases vascular smooth muscle cell proliferation via protein phosphatase 2A-mediated p70 S6 kinase inhibition. ( Cho, DH; Hwang, YJ; Lee, H; Park, JH, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (33.33) | 29.6817 |
| 2010's | 8 (53.33) | 24.3611 |
| 2020's | 2 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, H | 1 |
| Hwang, YJ | 1 |
| Park, JH | 1 |
| Cho, DH | 1 |
| Karatoprak, E | 1 |
| Tosun, O | 1 |
| Phabphal, K | 1 |
| Geater, A | 1 |
| Mehrpour, M | 1 |
| Shojaie, M | 1 |
| Zamani, B | 1 |
| Gharibzadeh, S | 1 |
| Abbasi, M | 1 |
| Płonka-Półtorak, E | 1 |
| Zagrodzki, P | 1 |
| Kryczyk-Kozioł, J | 1 |
| Westermarck, T | 1 |
| Kaipainen, P | 1 |
| Kaski, M | 1 |
| Atroshi, F | 1 |
| Erdemir, A | 1 |
| Cullu, N | 1 |
| Yiş, U | 1 |
| Demircioğlu, F | 1 |
| Kir, M | 1 |
| Cakmakçi, H | 1 |
| Unal, N | 1 |
| Dirik, E | 1 |
| Bowes, AJ | 3 |
| Khan, MI | 3 |
| Shi, Y | 3 |
| Robertson, L | 1 |
| Werstuck, GH | 3 |
| Castro-Gago, M | 1 |
| Eirís-Puñal, J | 1 |
| Pichna, BA | 1 |
| McAlpine, CS | 1 |
| Chuang, YC | 1 |
| Chuang, HY | 1 |
| Lin, TK | 1 |
| Chang, CC | 1 |
| Lu, CH | 1 |
| Chang, WN | 1 |
| Chen, SD | 1 |
| Tan, TY | 1 |
| Huang, CR | 1 |
| Chan, SH | 1 |
| Yildiz, M | 1 |
| Oz, O | 1 |
| Akgün, H | 1 |
| Yücel, M | 1 |
| Gökçil, Z | 1 |
| Odabaşi, Z | 1 |
| Emeksiz, HC | 1 |
| Serdaroglu, A | 1 |
| Biberoglu, G | 1 |
| Gulbahar, O | 1 |
| Arhan, E | 1 |
| Cansu, A | 1 |
| Arga, M | 1 |
| Hasanoglu, A | 1 |
| Tekgul, H | 1 |
| Demir, N | 1 |
| Gokben, S | 1 |
15 other studies available for valproic acid and Atherogenesis
| Article | Year |
|---|---|
Valproic acid decreases vascular smooth muscle cell proliferation via protein phosphatase 2A-mediated p70 S6 kinase inhibition.
Topics: Animals; Atherosclerosis; Cell Proliferation; Cells, Cultured; Muscle, Smooth, Vascular; Myocytes, S | 2022 |
Effects of valproic acid and levetiracetam monotherapy on carotid intima-media and epicardial adipose tissue thickness in non-obese children with epilepsy.
Topics: Adipose Tissue; Anticonvulsants; Atherosclerosis; Body Mass Index; Carotid Arteries; Carotid Intima- | 2020 |
The association between BsmI polymorphism and risk factors for atherosclerosis in patients with epilepsy taking valproate.
Topics: Adult; Anticonvulsants; Atherosclerosis; Cholesterol; Cross-Sectional Studies; Epilepsy; Female; Hum | 2013 |
Atherogenic consequence of antiepileptic drugs: a study of intima-media thickness.
Topics: Adult; Age Factors; Anticonvulsants; Atherosclerosis; Carotid Arteries; Carotid Intima-Media Thickne | 2014 |
Does valproate therapy in epileptic patients contribute to changing atherosclerosis risk factors? The role of lipids and free fatty acids.
Topics: Adult; Atherosclerosis; Cohort Studies; Cross-Sectional Studies; Epilepsy; Fatty Acids, Nonesterifie | 2016 |
Evaluation of serum lipids and carotid artery intima media thickness in epileptic children treated with valproic acid.
Topics: Adolescent; Atherosclerosis; Carotid Artery, Common; Carotid Stenosis; Child; Cholesterol, HDL; Chol | 2009 |
Valproate attenuates accelerated atherosclerosis in hyperglycemic apoE-deficient mice: evidence in support of a role for endoplasmic reticulum stress and glycogen synthase kinase-3 in lesion development and hepatic steatosis.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Blotting, Western; Cells, Cultured; Endoplasmic Reticul | 2009 |
Correspondence on "Lipid profile, apolipoproteins A and B in children with epilepsy''.
Topics: Adolescent; Anticonvulsants; Apolipoprotein A-I; Apolipoproteins; Apolipoproteins B; Atherosclerosis | 2009 |
Evidence supporting a role for endoplasmic reticulum stress in the development of atherosclerosis in a hyperglycaemic mouse model.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Cells, Cultured; Disease Models, Animal; Endoplasmic Re | 2009 |
Endoplasmic reticulum stress and glycogen synthase kinase-3β activation in apolipoprotein E-deficient mouse models of accelerated atherosclerosis.
Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; Diet, High-Fat; Disease Models, Animal; Endoplas | 2012 |
Effects of long-term antiepileptic drug monotherapy on vascular risk factors and atherosclerosis.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Atherosclerosis; Blood Glucose; Carbamazepine; Carotid Art | 2012 |
Thyroid hormones may contribute to vascular risk factors and atherosclerosis.
Topics: Anticonvulsants; Atherosclerosis; Carbamazepine; Carotid Artery, Common; Epilepsy; Female; Humans; M | 2012 |
Asymmetric dimethylarginine may contribute to vascular risk factors in patients receiving antiepileptic drug treatment.
Topics: Anticonvulsants; Atherosclerosis; Carbamazepine; Carotid Artery, Common; Epilepsy; Female; Humans; M | 2012 |
Assessment of atherosclerosis risk due to the homocysteine-asymmetric dimethylarginine-nitric oxide cascade in children taking antiepileptic drugs.
Topics: Adolescent; Anticonvulsants; Arginine; Atherosclerosis; Biomarkers; Carbamazepine; Child; Epilepsy; | 2013 |
Serum lipid profile in children receiving anti-epileptic drug monotherapy: is it atherogenic?
Topics: Adolescent; Anticonvulsants; Apolipoproteins; Atherosclerosis; Carbamazepine; Child; Cholesterol, HD | 2006 |