valproic acid has been researched along with Ataxia in 19 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Ataxia: Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 28-year-old patient with a 5-year history of bipolar disorder developed signs of encephalopathy 2 weeks after the addition of valproic acid to his treatment regimen of doxepine, risperidone, and biperidene." | 7.70 | [Valproic acid in prophylaxis of bipolar disorder. A case of valproate-induced encephalopathy]. ( Rottach, KG; Schmauss, M; Weiss-Brummer, J; Wieland, U, 2000) |
| "Acute ataxia is commonly the chief complaint among patients visiting the emergency department (ED)." | 5.72 | A Phenytoin-Induced Ataxia Mimicking a Stroke. ( Urushidani, S, 2022) |
| "A 28-year-old patient with a 5-year history of bipolar disorder developed signs of encephalopathy 2 weeks after the addition of valproic acid to his treatment regimen of doxepine, risperidone, and biperidene." | 3.70 | [Valproic acid in prophylaxis of bipolar disorder. A case of valproate-induced encephalopathy]. ( Rottach, KG; Schmauss, M; Weiss-Brummer, J; Wieland, U, 2000) |
| "Since the emergence of coronavirus disease 2019 (COVID-19), neurological symptoms, syndromes, and complications associated with this multi-organ viral infection have been reported and the various aspects of neurological involvement are increasingly uncovered." | 2.72 | Opsoclonus-myoclonus syndrome, a post-infectious neurologic complication of COVID-19: case series and review of literature. ( Aghavali, S; Babadi, M; Daraie, P; Emamikhah, M; Jalili, M; Mehrabani, M; Mohaghegh, F; Pouranian, M; Rohani, M; Zaribafian, M, 2021) |
| "Acute ataxia is commonly the chief complaint among patients visiting the emergency department (ED)." | 1.72 | A Phenytoin-Induced Ataxia Mimicking a Stroke. ( Urushidani, S, 2022) |
| "Ataxia was observed in 7/34 cases." | 1.48 | Defining the phenotypic spectrum of SLC6A1 mutations. ( Abi-Warde, MT; Afenjar, A; Bird, LM; Carvill, GL; Chae, JH; Chelly, J; Choi, M; Christensen, J; Courage, C; Czapansky-Beilman, D; de Saint Martin, A; Devinsky, O; Doummar, D; Dubbs, H; Gardella, E; Gleeson, JG; Helbig, I; Helbig, KL; Hopkins, S; Johannesen, KM; Keren, B; Lehesjoki, AE; Lesca, G; Linnankivi, T; Mecarelli, O; Mefford, HC; Merritt, JL; Mignot, C; Millichap, JJ; Myers, CT; Møller, RS; Nava, C; Nespeca, M; Pal, DK; Pendziwiat, M; Pisani, L; Piton, A; Reichert, SC; Rodan, LH; Rubboli, G; Schaefer, E; Schelhaas, HJ; Shaw, JE; Specchio, N; Striano, P; Tan, WH; Tang, S; Trivisano, M; Verhoeven, JS; Weber, YG; Yoo, Y, 2018) |
| "Individuals treated with combined valproate-lamotrigine rarely present late adverse effects (unrelated to introduction and titration)." | 1.38 | Late adverse effects of the coadministration of valproate and lamotrigine. ( Moreira, B; Thome-Souza, S; Valente, KD, 2012) |
| "A 23-year-old man had unilateral rubral tremors as a result of a midbrain lesion plus risperidone exposure for treatment of manic symptoms." | 1.35 | Unilateral rubral tremor following treatment with risperidone. ( Shen, YC, 2009) |
| " In this study, we examined the anticonvulsant and adverse effects of the three clinically established AEDs carbamazepine (CBZ), phenobarbital (PB), and valproate (VPA) once per month in the same two groups of amygdala-kindled rats over a period of 9 (group 1) or 6 (group 2) consecutive months." | 1.31 | Repeated acute testing of anticonvulsant drugs in amygdala kindled rats: increase in anticonvulsant but decrease in adverse effect potential. ( Fiedler, M; Löscher, W, 2000) |
| "Development of novel antiepileptic drugs (AEDs) requires determining the margin between the desired anticonvulsant effect and undesired adverse effects (AE) (therapeutic index)." | 1.29 | Kindling increases the sensitivity of rats to adverse effects of certain antiepileptic drugs. ( Hönack, D; Löscher, W, 1995) |
| "5-5 mg/kg, CGP 37849 potentiated the adverse effects but not the anticonvulsant activity of 50 mg/kg valproate." | 1.29 | Effects of the competitive NMDA receptor antagonist, CGP 37849, on anticonvulsant activity and adverse effects of valproate in amygdala-kindled rats. ( Hönack, D; Löscher, W, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (15.79) | 18.7374 |
| 1990's | 3 (15.79) | 18.2507 |
| 2000's | 4 (21.05) | 29.6817 |
| 2010's | 6 (31.58) | 24.3611 |
| 2020's | 3 (15.79) | 2.80 |
| Authors | Studies |
|---|---|
| Urushidani, S | 1 |
| Yuan, B | 1 |
| Luo, L | 1 |
| Hu, C | 1 |
| Lin, F | 1 |
| Yang, T | 1 |
| Chen, J | 1 |
| Li, T | 1 |
| Emamikhah, M | 1 |
| Babadi, M | 1 |
| Mehrabani, M | 1 |
| Jalili, M | 1 |
| Pouranian, M | 1 |
| Daraie, P | 1 |
| Mohaghegh, F | 1 |
| Aghavali, S | 1 |
| Zaribafian, M | 1 |
| Rohani, M | 1 |
| Androsova, G | 1 |
| Krause, R | 1 |
| Borghei, M | 1 |
| Wassenaar, M | 1 |
| Auce, P | 1 |
| Avbersek, A | 1 |
| Becker, F | 1 |
| Berghuis, B | 1 |
| Campbell, E | 1 |
| Coppola, A | 1 |
| Francis, B | 1 |
| Wolking, S | 1 |
| Cavalleri, GL | 1 |
| Craig, J | 1 |
| Delanty, N | 1 |
| Koeleman, BPC | 1 |
| Kunz, WS | 1 |
| Lerche, H | 1 |
| Marson, AG | 1 |
| Sander, JW | 1 |
| Sills, GJ | 1 |
| Striano, P | 2 |
| Zara, F | 1 |
| Sisodiya, SM | 1 |
| Depondt, C | 1 |
| Johannesen, KM | 1 |
| Gardella, E | 1 |
| Linnankivi, T | 1 |
| Courage, C | 1 |
| de Saint Martin, A | 1 |
| Lehesjoki, AE | 1 |
| Mignot, C | 1 |
| Afenjar, A | 1 |
| Lesca, G | 1 |
| Abi-Warde, MT | 1 |
| Chelly, J | 1 |
| Piton, A | 1 |
| Merritt, JL | 1 |
| Rodan, LH | 1 |
| Tan, WH | 1 |
| Bird, LM | 1 |
| Nespeca, M | 1 |
| Gleeson, JG | 1 |
| Yoo, Y | 1 |
| Choi, M | 1 |
| Chae, JH | 1 |
| Czapansky-Beilman, D | 1 |
| Reichert, SC | 1 |
| Pendziwiat, M | 1 |
| Verhoeven, JS | 1 |
| Schelhaas, HJ | 1 |
| Devinsky, O | 1 |
| Christensen, J | 1 |
| Specchio, N | 1 |
| Trivisano, M | 1 |
| Weber, YG | 1 |
| Nava, C | 1 |
| Keren, B | 1 |
| Doummar, D | 1 |
| Schaefer, E | 1 |
| Hopkins, S | 1 |
| Dubbs, H | 1 |
| Shaw, JE | 1 |
| Pisani, L | 1 |
| Myers, CT | 1 |
| Tang, S | 2 |
| Pal, DK | 1 |
| Millichap, JJ | 1 |
| Carvill, GL | 1 |
| Helbig, KL | 1 |
| Mecarelli, O | 1 |
| Helbig, I | 1 |
| Rubboli, G | 1 |
| Mefford, HC | 1 |
| Møller, RS | 1 |
| Huang, Q | 1 |
| Yu, L | 1 |
| Ma, M | 1 |
| Qi, H | 1 |
| Wu, Y | 1 |
| Main, SL | 1 |
| Kulesza, RJ | 1 |
| Shen, YC | 1 |
| Hakonen, AH | 1 |
| Isohanni, P | 1 |
| Rantamäki, M | 1 |
| Kälviäinen, R | 1 |
| Nordin, A | 1 |
| Uusimaa, J | 1 |
| Paetau, A | 1 |
| Udd, B | 1 |
| Pihko, H | 1 |
| Wartiovaara, A | 1 |
| Thome-Souza, S | 1 |
| Moreira, B | 1 |
| Valente, KD | 1 |
| Hommet, C | 1 |
| Mondon, K | 1 |
| de Toffol, B | 1 |
| Constans, T | 1 |
| Perlman, BJ | 1 |
| Goldstein, DB | 1 |
| Hönack, D | 2 |
| Löscher, W | 3 |
| Roks, G | 1 |
| Deckers, CL | 1 |
| Meinardi, H | 1 |
| Dirksen, R | 1 |
| van Egmond, J | 1 |
| van Rijn, CM | 1 |
| Fiedler, M | 1 |
| Rottach, KG | 1 |
| Weiss-Brummer, J | 1 |
| Wieland, U | 1 |
| Schmauss, M | 1 |
| Lander, CM | 1 |
| Donnan, GA | 1 |
| Bladin, PF | 1 |
| Vajda, FJ | 1 |
| Shakir, RA | 1 |
| Nanda, RN | 1 |
| Lambie, DG | 1 |
| Johnson, RH | 1 |
1 review available for valproic acid and Ataxia
| Article | Year |
|---|---|
Opsoclonus-myoclonus syndrome, a post-infectious neurologic complication of COVID-19: case series and review of literature.
Topics: Adult; Anticonvulsants; Ataxia; Azithromycin; Clonazepam; Cough; COVID-19; COVID-19 Drug Treatment; | 2021 |
18 other studies available for valproic acid and Ataxia
| Article | Year |
|---|---|
A Phenytoin-Induced Ataxia Mimicking a Stroke.
Topics: Ataxia; Carbamazepine; Female; Humans; Middle Aged; Phenytoin; Stroke; Valproic Acid | 2022 |
Retinoic acid supplementation ameliorates motor incoordination via RARα-CBLN2 in the cerebellum of a prenatal valproic acid-exposed rat autism model.
Topics: Animals; Ataxia; Autism Spectrum Disorder; Autistic Disorder; Cerebellum; Dietary Supplements; Disea | 2023 |
Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis.
Topics: Adolescent; Adult; Aged; Amines; Anticonvulsants; Ataxia; Benzodiazepines; Carbamazepine; Clobazam; | 2017 |
Defining the phenotypic spectrum of SLC6A1 mutations.
Topics: Adolescent; Adult; Anticonvulsants; Ataxia; Child; Child, Preschool; Cohort Studies; Electroencephal | 2018 |
Novel SCN2A mutation in a family associated with juvenile-onset myoclonus: Case report.
Topics: Adult; Anticonvulsants; Ataxia; Carbamazepine; Disease Progression; Drug Resistant Epilepsy; Electro | 2019 |
Repeated prenatal exposure to valproic acid results in cerebellar hypoplasia and ataxia.
Topics: Administration, Oral; Animals; Ataxia; Calbindins; Cell Size; Cerebellum; Developmental Disabilities | 2017 |
Unilateral rubral tremor following treatment with risperidone.
Topics: Anticonvulsants; Antipsychotic Agents; Ataxia; Behavior Therapy; Bipolar Disorder; Brain; Carbamazep | 2009 |
[Mitochondrial recessive ataxia syndrome (MIRAS) and valproate toxicity].
Topics: Anticonvulsants; Ataxia; DNA, Mitochondrial; Genes, Recessive; Humans; Liver Failure; Mutation; Synd | 2010 |
Late adverse effects of the coadministration of valproate and lamotrigine.
Topics: Adolescent; Anticonvulsants; Ataxia; Child; Drug Therapy, Combination; Epilepsy; Female; Headache; H | 2012 |
Reversible cognitive and neurological symptoms during valproic acid therapy.
Topics: Aged, 80 and over; Anticonvulsants; Ataxia; Cognition Disorders; Humans; Male; Seizures; Valproic Ac | 2007 |
Genetic influences on the central nervous system depressant and membrane-disordering actions of ethanol and sodium valproate.
Topics: Animals; Ataxia; Brain; Cell Membrane; Central Nervous System Depressants; Electron Spin Resonance S | 1984 |
Kindling increases the sensitivity of rats to adverse effects of certain antiepileptic drugs.
Topics: Animals; Anticonvulsants; Ataxia; Behavior, Animal; Carbolines; Dose-Response Relationship, Drug; Fe | 1995 |
Effects of the competitive NMDA receptor antagonist, CGP 37849, on anticonvulsant activity and adverse effects of valproate in amygdala-kindled rats.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Anticonvulsants; Ataxia; Female; Kindling, Neurologi | 1993 |
Effects of polytherapy compared with monotherapy in antiepileptic drugs: an animal study.
Topics: Animals; Anticonvulsants; Ataxia; Behavior, Animal; Dose-Response Relationship, Drug; Drug Interacti | 1999 |
Repeated acute testing of anticonvulsant drugs in amygdala kindled rats: increase in anticonvulsant but decrease in adverse effect potential.
Topics: Amygdala; Animals; Anticonvulsants; Ataxia; Behavior, Animal; Carbamazepine; Disease Models, Animal; | 2000 |
[Valproic acid in prophylaxis of bipolar disorder. A case of valproate-induced encephalopathy].
Topics: Adult; Antimanic Agents; Ataxia; Bipolar Disorder; Brain Diseases, Metabolic; Dyskinesias; Epilepsy, | 2000 |
Some aspects of the clinical use of clonazepam in refractory epilepsy.
Topics: Adolescent; Adult; Ataxia; Benzodiazepinones; Child; Clonazepam; Depression; Drug Therapy, Combinati | 1979 |
Comparative trial of valproate sodium and clonazepam in chronic epilepsy.
Topics: Adult; Ataxia; Benzodiazepinones; Chronic Disease; Clonazepam; Drug Therapy, Combination; Epilepsy; | 1979 |