valproic acid has been researched along with Asystole in 20 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "It has been reported that valproic acid (VPA) combined with therapeutic hypothermia can improve survival and neurologic outcomes in a rat asphyxial cardiac arrest model." | 8.02 | HSP70-mediated neuroprotection by combined treatment of valproic acid with hypothermia in a rat asphyxial cardiac arrest model. ( Choi, KH; Choi, S; Jeong, HH; Kim, K; Oh, JS; Oh, YM; Park, J, 2021) |
| "High-dose valproic acid combined with hypothermic-targeted temperature management prevents postcardiac arrest seizures and improves survival." | 7.85 | Valproic Acid Combined With Postcardiac Arrest Hypothermic-Targeted Temperature Management Prevents Delayed Seizures and Improves Survival in a Rat Cardiac Arrest Model. ( Neumar, RW; Oh, JS; Stacey, WC; Tulasi, J; Xiaodan, R, 2017) |
| "Valproic acid (VPA) has been reported to have survival and neuroprotective effects in a cardiac arrest rat model." | 5.42 | Effect of valproic acid combined with therapeutic hypothermia on neurologic outcome in asphyxial cardiac arrest model of rats. ( Hwang, JE; Jo, YH; Kim, K; Kim, MA; Lee, JH; Lee, MJ, 2015) |
| "Valproic acid (VPA) has been known to reduce neuronal injury, has anti-inflammatory and anti-apoptotic effects as a histone deacetylase (HDAC) inhibitor." | 5.39 | Effect of valproic acid on survival and neurologic outcomes in an asphyxial cardiac arrest model of rats. ( Jo, YH; Kang, C; Kim, J; Kim, K; Kim, MA; Lee, JH; Lee, MJ; Lee, SH; Park, CJ; Rhee, JE, 2013) |
| "It has been reported that valproic acid (VPA) combined with therapeutic hypothermia can improve survival and neurologic outcomes in a rat asphyxial cardiac arrest model." | 4.02 | HSP70-mediated neuroprotection by combined treatment of valproic acid with hypothermia in a rat asphyxial cardiac arrest model. ( Choi, KH; Choi, S; Jeong, HH; Kim, K; Oh, JS; Oh, YM; Park, J, 2021) |
| "High-dose valproic acid combined with hypothermic-targeted temperature management prevents postcardiac arrest seizures and improves survival." | 3.85 | Valproic Acid Combined With Postcardiac Arrest Hypothermic-Targeted Temperature Management Prevents Delayed Seizures and Improves Survival in a Rat Cardiac Arrest Model. ( Neumar, RW; Oh, JS; Stacey, WC; Tulasi, J; Xiaodan, R, 2017) |
| "Chronic post-hypoxic myoclonus is a condition in which the predominant clinical picture is myoclonus following hypoxic brain damage, usually due to cardiorespiratory arrest." | 1.62 | [Response to perampanel in a patient with chronic post-hypoxic myoclonus]. ( de Toledo, M; Muro-García, I; Pastor, J; Vega, L; Vieira, A, 2021) |
| "We studied an observational cohort of comatose subjects treated at a single academic medical center after cardiac arrest from September 2010 to January 2018." | 1.51 | Association of antiepileptic drugs with resolution of epileptiform activity after cardiac arrest. ( Baldwin, MA; Callaway, CW; Coppler, PJ; Elmer, J; Kvaløy, JT; Solanki, P, 2019) |
| "Early myoclonus after cardiac arrest (CA) is traditionally viewed as a poor prognostic sign (status myoclonus)." | 1.46 | Early Lance-Adams syndrome after cardiac arrest: Prevalence, time to return to awareness, and outcome in a large cohort. ( Aicua Rapun, I; Novy, J; Oddo, M; Rossetti, AO; Solari, D, 2017) |
| "Valproic acid (VPA) has been reported to have survival and neuroprotective effects in a cardiac arrest rat model." | 1.42 | Effect of valproic acid combined with therapeutic hypothermia on neurologic outcome in asphyxial cardiac arrest model of rats. ( Hwang, JE; Jo, YH; Kim, K; Kim, MA; Lee, JH; Lee, MJ, 2015) |
| "Valproic acid (VPA) has been known to reduce neuronal injury, has anti-inflammatory and anti-apoptotic effects as a histone deacetylase (HDAC) inhibitor." | 1.39 | Effect of valproic acid on survival and neurologic outcomes in an asphyxial cardiac arrest model of rats. ( Jo, YH; Kang, C; Kim, J; Kim, K; Kim, MA; Lee, JH; Lee, MJ; Lee, SH; Park, CJ; Rhee, JE, 2013) |
| "Epilepsy was confirmed by EEG and many seizures episodes were treated with different combination of anticonvulsive drugs." | 1.38 | [Epileptic asystole - a case report]. ( Bałajewicz, J; Bryniarski, L; Czamara, M; Jastrzębski, M; Kukla, P; Przyprawa, A, 2012) |
| "Post-anoxic myoclonus is a rare movement disorder manifested by diffuse action-triggered jerking movements that may result in significant disability." | 1.33 | Post-anoxic myoclonus: a case presentation and review of management in the rehabilitation setting. ( Polesin, A; Stern, M, 2006) |
| "Three times acute cardiopulmonary arrest appeared during status asthmaticus." | 1.33 | [Lance-Adams syndrome in patient with anoxic encephalopathy in the course of bronchial asthma]. ( Budrewicz, SP; Koszewicz, MA; Kowalczyk, EE; Podemski, R; Słotwiński, K, 2006) |
| "The data suggest that this rat cardiac arrest model may be a valuable tool for investigating the pathophysiologic mechanisms of posthypoxic myoclonus and for developing new therapeutic strategies for treating the disorder." | 1.29 | Novel rat cardiac arrest model of posthypoxic myoclonus. ( Hussong, MJ; Matsumoto, RR; Schwartz, PH; Truong, DD; Wasterlain, CG, 1994) |
| "Cerebral coma, which lasted for twenty hrs, was followed by an undisturbed period of approximately sixteen hrs." | 1.27 | Acute valproate intoxication with fatal outcome in an infant. ( Janssen, F; Rambeck, B; Schnabel, R, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (10.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 5 (25.00) | 29.6817 |
| 2010's | 7 (35.00) | 24.3611 |
| 2020's | 4 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Marcellino, C | 1 |
| Wijdicks, EF | 1 |
| Hunt, MF | 1 |
| Clark, KT | 1 |
| Grant, MC | 1 |
| Choi, CW | 1 |
| Whitman, G | 1 |
| Cho, SM | 1 |
| Farrokh, S | 1 |
| Oh, JS | 2 |
| Park, J | 1 |
| Kim, K | 3 |
| Jeong, HH | 1 |
| Oh, YM | 1 |
| Choi, S | 1 |
| Choi, KH | 1 |
| Muro-García, I | 1 |
| Vieira, A | 1 |
| Vega, L | 1 |
| Pastor, J | 1 |
| de Toledo, M | 1 |
| Aicua Rapun, I | 1 |
| Novy, J | 1 |
| Solari, D | 1 |
| Oddo, M | 1 |
| Rossetti, AO | 1 |
| Tulasi, J | 1 |
| Xiaodan, R | 1 |
| Stacey, WC | 1 |
| Neumar, RW | 1 |
| Solanki, P | 1 |
| Coppler, PJ | 1 |
| Kvaløy, JT | 1 |
| Baldwin, MA | 1 |
| Callaway, CW | 1 |
| Elmer, J | 1 |
| Lee, JH | 2 |
| Jo, YH | 2 |
| Lee, SH | 1 |
| Kang, C | 1 |
| Kim, J | 1 |
| Park, CJ | 1 |
| Kim, MA | 2 |
| Lee, MJ | 2 |
| Rhee, JE | 1 |
| Hilly-Ginoux, J | 1 |
| Merceron, S | 1 |
| Pinoteau, J | 1 |
| Palette, C | 1 |
| Bedos, JP | 1 |
| Legriel, S | 1 |
| Hwang, JE | 1 |
| Dinis-Oliveira, RJ | 1 |
| Magalhães, T | 1 |
| Carvalho, F | 1 |
| Santos, A | 1 |
| Kukla, P | 1 |
| Jastrzębski, M | 1 |
| Czamara, M | 1 |
| Bryniarski, L | 1 |
| Przyprawa, A | 1 |
| Bałajewicz, J | 1 |
| Marill, KA | 1 |
| Ellinor, PT | 1 |
| Polesin, A | 1 |
| Stern, M | 1 |
| Kowalczyk, EE | 1 |
| Koszewicz, MA | 1 |
| Budrewicz, SP | 1 |
| Podemski, R | 1 |
| Słotwiński, K | 1 |
| Unal, E | 1 |
| Kaya, U | 1 |
| Aydin, K | 1 |
| Truong, DD | 1 |
| Matsumoto, RR | 1 |
| Schwartz, PH | 1 |
| Hussong, MJ | 1 |
| Wasterlain, CG | 1 |
| Zarate, CA | 1 |
| Baldessarini, RJ | 1 |
| Siegel, AJ | 1 |
| Nakamura, A | 1 |
| McDonald, J | 1 |
| Muir-Hutchinson, LA | 1 |
| Cherkerzian, T | 1 |
| Tohen, M | 1 |
| Fahn, S | 1 |
| Janssen, F | 1 |
| Rambeck, B | 1 |
| Schnabel, R | 1 |
1 review available for valproic acid and Asystole
| Article | Year |
|---|---|
Posthypoxic action myoclonus: literature review update.
Topics: Adult; Clonazepam; Coma; Electroencephalography; Female; Functional Laterality; Heart Arrest; Humans | 1986 |
19 other studies available for valproic acid and Asystole
| Article | Year |
|---|---|
Posthypoxic action myoclonus (the Lance-Adams syndrome).
Topics: Heart Arrest; Humans; Hypoxia, Brain; Levetiracetam; Male; Middle Aged; Myoclonus; Syndrome; Valproi | 2020 |
Therapeutic drug monitoring of valproic acid in extracorporeal membrane oxygenation.
Topics: Drug Monitoring; Extracorporeal Membrane Oxygenation; Heart Arrest; Humans; Valproic Acid | 2021 |
HSP70-mediated neuroprotection by combined treatment of valproic acid with hypothermia in a rat asphyxial cardiac arrest model.
Topics: Acetylation; Animals; Asphyxia; Combined Modality Therapy; Disease Models, Animal; Heart Arrest; HSP | 2021 |
[Response to perampanel in a patient with chronic post-hypoxic myoclonus].
Topics: Anticonvulsants; Carcinoma, Papillary; Clonazepam; Drug Therapy, Combination; Electroencephalography | 2021 |
Early Lance-Adams syndrome after cardiac arrest: Prevalence, time to return to awareness, and outcome in a large cohort.
Topics: Adult; Aged, 80 and over; Anticonvulsants; Cardiopulmonary Resuscitation; Clonazepam; Drug Combinati | 2017 |
Valproic Acid Combined With Postcardiac Arrest Hypothermic-Targeted Temperature Management Prevents Delayed Seizures and Improves Survival in a Rat Cardiac Arrest Model.
Topics: Animals; Heart Arrest; Hypothermia, Induced; Male; Prospective Studies; Rats; Rats, Long-Evans; Seiz | 2017 |
Association of antiepileptic drugs with resolution of epileptiform activity after cardiac arrest.
Topics: Anticonvulsants; Cohort Studies; Coma; Combined Modality Therapy; Electroencephalography; Female; He | 2019 |
Effect of valproic acid on survival and neurologic outcomes in an asphyxial cardiac arrest model of rats.
Topics: Animals; Asphyxia; Brain Diseases; Disease Models, Animal; Enzyme Inhibitors; Heart Arrest; Male; Ra | 2013 |
Intravenous valproate in twelve patients with post-anoxic status epilepticus.
Topics: Adult; Aged; Aged, 80 and over; Cardiopulmonary Resuscitation; Cohort Studies; Dose-Response Relatio | 2013 |
Effect of valproic acid combined with therapeutic hypothermia on neurologic outcome in asphyxial cardiac arrest model of rats.
Topics: Animals; Asphyxia; Brain Diseases; Combined Modality Therapy; Disease Models, Animal; Enzyme Inhibit | 2015 |
A cocaine body packer case report: clinical and forensic aspects.
Topics: Anticonvulsants; Cocaine; Crime; Digestive System; Epilepsy; Fatal Outcome; Foreign Bodies; Forensic | 2009 |
[Epileptic asystole - a case report].
Topics: Anticonvulsants; Electroencephalography; Epilepsy; Female; Heart Arrest; Humans; Middle Aged; Pacema | 2012 |
Case records of the Massachusetts General Hospital. Case 37-2005. A 35-year-old man with cardiac arrest while sleeping.
Topics: Adult; Bundle-Branch Block; Death, Sudden, Cardiac; Diagnosis, Differential; Electrocardiography; Fa | 2005 |
Post-anoxic myoclonus: a case presentation and review of management in the rehabilitation setting.
Topics: Anticonvulsants; Clonazepam; Diazepam; Female; Heart Arrest; Humans; Hypoxia, Brain; Isoxazoles; Lev | 2006 |
[Lance-Adams syndrome in patient with anoxic encephalopathy in the course of bronchial asthma].
Topics: Adult; Asthma; Cardiopulmonary Resuscitation; Diagnosis, Differential; Electroencephalography; Femal | 2006 |
Fatal valproate overdose in a newborn baby.
Topics: Anticonvulsants; Brain Edema; Drug Overdose; Fatal Outcome; Female; Heart Arrest; Humans; Infant, Ne | 2007 |
Novel rat cardiac arrest model of posthypoxic myoclonus.
Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Animals; Anticonvulsants; Clonazepam; Disease Models, Ani | 1994 |
Risperidone in the elderly: a pharmacoepidemiologic study.
Topics: Age Factors; Aged; Aged, 80 and over; Basal Ganglia Diseases; Cardiovascular Diseases; Comorbidity; | 1997 |
Acute valproate intoxication with fatal outcome in an infant.
Topics: Brain; Coma; Heart Arrest; Humans; Infant; Male; Neurons; Respiratory Paralysis; Valproic Acid | 1985 |