valproic acid has been researched along with Astrocytoma in 11 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Inositol uptake was measured at concentrations of 25, 40 and 50 microM in human astrocytoma cell cultures treated for 1-3 weeks with pharmacologically relevant concentrations of LiCl, valproic acid or carbamazepine as well as in control cultures that had not been treated with any drug." | 7.70 | Chronic treatment of human astrocytoma cells with lithium, carbamazepine or valproic acid decreases inositol uptake at high inositol concentrations but increases it at low inositol concentrations. ( Belmaker, RH; Bersudsky, Y; Hertz, L; Simkin, M; Wolfson, M; Zinger, E, 2000) |
| " The authors examined the effect of VPA at therapeutic concentrations (300 and 600 microM) on the elevation of intracellular free calcium concentration ([Ca(2+)](i)) induced by carbachol, a muscarinic receptor agonist, in 1321N1 human astrocytoma cells." | 3.74 | Sodium valproate at therapeutic concentrations changes Ca2+ response accompanied with its weak inhibition of protein kinase C in human astrocytoma cells. ( Kurita, M; Mashiko, H; Nakahata, N; Nishino, S; Niwa, S; Ohtomo, K; Rai, M; Shirakawa, H, 2007) |
| "Inositol uptake was measured at concentrations of 25, 40 and 50 microM in human astrocytoma cell cultures treated for 1-3 weeks with pharmacologically relevant concentrations of LiCl, valproic acid or carbamazepine as well as in control cultures that had not been treated with any drug." | 3.70 | Chronic treatment of human astrocytoma cells with lithium, carbamazepine or valproic acid decreases inositol uptake at high inositol concentrations but increases it at low inositol concentrations. ( Belmaker, RH; Bersudsky, Y; Hertz, L; Simkin, M; Wolfson, M; Zinger, E, 2000) |
| "Valproic acid (VPA) has been recently investigated for its anticancer properties in different tumors, including malignant gliomas." | 1.34 | Valproic acid increases the in vitro effects of nitrosureas on human glioma cell lines. ( Balzarotti, M; Boiardi, A; Calatozzolo, C; Ciusani, E; Croci, D; de Grazia, U; Salmaggi, A, 2007) |
| "The case of a 12-year-old boy with anaplastic astrocytoma of the left thalamus is reported." | 1.33 | Combined treatment of pediatric high-grade glioma with the oncolytic viral strain MTH-68/H and oral valproic acid. ( Csatary, CM; Csatary, LK; Gosztonyi, G; Hartmann, C; Hernáiz-Driever, P; Koch, HC; Längler, A; Peters, O; Théallier-Janko, A; Wagner, S; Wolff, JE; Zintl, F, 2006) |
| "Right hemispheric brain tumors involving the orbitofrontal or basotemporal cortex are a rare cause of secondary mania." | 1.32 | Exacerbation of mania secondary to right temporal lobe astrocytoma in a bipolar patient previously stabilized on valproate. ( Denson, TF; Sokolski, KN, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 7 (63.64) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lamarre, M | 1 |
| Desrosiers, RR | 1 |
| Fisch, L | 1 |
| Mégevand, P | 1 |
| Badoud, S | 1 |
| Badoud, A | 1 |
| Seeck, M | 1 |
| Burkhard, PR | 1 |
| Sokolski, KN | 1 |
| Denson, TF | 1 |
| Wagner, S | 1 |
| Csatary, CM | 1 |
| Gosztonyi, G | 1 |
| Koch, HC | 1 |
| Hartmann, C | 1 |
| Peters, O | 1 |
| Hernáiz-Driever, P | 1 |
| Théallier-Janko, A | 1 |
| Zintl, F | 1 |
| Längler, A | 1 |
| Wolff, JE | 1 |
| Csatary, LK | 1 |
| Kurita, M | 1 |
| Nishino, S | 1 |
| Ohtomo, K | 1 |
| Rai, M | 1 |
| Shirakawa, H | 1 |
| Mashiko, H | 1 |
| Niwa, S | 1 |
| Nakahata, N | 1 |
| Ciusani, E | 1 |
| Balzarotti, M | 1 |
| Calatozzolo, C | 1 |
| de Grazia, U | 1 |
| Boiardi, A | 1 |
| Salmaggi, A | 1 |
| Croci, D | 1 |
| Hennessy, MJ | 1 |
| Wiles, CM | 1 |
| Cortés, V | 1 |
| Landete, L | 1 |
| Gómez, E | 1 |
| Blasco, R | 1 |
| Wolfson, M | 1 |
| Bersudsky, Y | 1 |
| Zinger, E | 1 |
| Simkin, M | 1 |
| Belmaker, RH | 1 |
| Hertz, L | 1 |
| Proulle, V | 1 |
| Masnou, P | 1 |
| Cartron, J | 1 |
| Kaplan, C | 1 |
| Ajzenberg, N | 1 |
| Tchernia, G | 1 |
| Dreyfus, M | 1 |
| Gensburger, C | 1 |
| Simler, S | 1 |
| Ciesielski, L | 1 |
| Mandel, P | 1 |
11 other studies available for valproic acid and Astrocytoma
| Article | Year |
|---|---|
Up-regulation of protein L-isoaspartyl methyltransferase expression by lithium is mediated by glycogen synthase kinase-3 inactivation and beta-catenin stabilization.
Topics: Adjuvants, Immunologic; Astrocytoma; beta Catenin; Cell Line, Tumor; Dose-Response Relationship, Dru | 2008 |
Pilomotor seizure: when paroxysmal gooseflesh heralds brain tumor.
Topics: Aged; Amygdala; Anticonvulsants; Astrocytoma; Brain Neoplasms; Electroencephalography; Hippocampus; | 2012 |
Exacerbation of mania secondary to right temporal lobe astrocytoma in a bipolar patient previously stabilized on valproate.
Topics: Anticonvulsants; Antimanic Agents; Astrocytoma; Bipolar Disorder; Brain Neoplasms; Disease Progressi | 2003 |
Combined treatment of pediatric high-grade glioma with the oncolytic viral strain MTH-68/H and oral valproic acid.
Topics: Administration, Oral; Anticonvulsants; Antigens, Viral; Astrocytoma; Brain; Brain Neoplasms; Child; | 2006 |
Sodium valproate at therapeutic concentrations changes Ca2+ response accompanied with its weak inhibition of protein kinase C in human astrocytoma cells.
Topics: Astrocytoma; Binding, Competitive; Calcium; Carbachol; Cell Line, Tumor; Cell Membrane; Cholinergic | 2007 |
Valproic acid increases the in vitro effects of nitrosureas on human glioma cell lines.
Topics: Acetylation; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Astrocytoma; Carmustine; Cel | 2007 |
Lamotrigine encephalopathy.
Topics: Anticonvulsants; Astrocytoma; Brain Diseases; Brain Neoplasms; Drug Interactions; Female; Frontal Lo | 1996 |
[Partial simple vegetative crisis: importance of electroencephalographic findings].
Topics: Anticonvulsants; Astrocytoma; Brain Neoplasms; Electroencephalography; Epilepsies, Partial; Female; | 1997 |
Chronic treatment of human astrocytoma cells with lithium, carbamazepine or valproic acid decreases inositol uptake at high inositol concentrations but increases it at low inositol concentrations.
Topics: Antimanic Agents; Astrocytoma; Bipolar Disorder; Brain; Brain Neoplasms; Carbamazepine; Dose-Respons | 2000 |
GPIaIIa as a candidate target for anti-platelet autoantibody occurring during valproate therapy and associated with peroperative bleeding.
Topics: Adult; Anticonvulsants; Astrocytoma; Autoantibodies; Blood Platelets; Brain Neoplasms; Female; Hemor | 2000 |
[Effect of sodium n-dipropylacetate (sodium valproate) on GABA level of neuronal and glial cells in culture].
Topics: Animals; Astrocytoma; Bucladesine; Cell Line; gamma-Aminobutyric Acid; Kinetics; Neuroblastoma; Rats | 1978 |