valproic acid has been researched along with Asthma in 5 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid treatment did not affect inflammation parameters; however, valproic acid treatment resulted in reduced epithelial thickness as compared to vehicle treated mice (p < 0." | 5.37 | Protective effects of valproic acid against airway hyperresponsiveness and airway remodeling in a mouse model of allergic airways disease. ( Dang, W; De Sampayo, N; El-Osta, A; Karagiannis, TC; Royce, SG; Tang, ML; Ververis, K, 2011) |
| "The ovalbumin-induced (OVA) chronic allergic airways murine model is a well-established model for investigating pre-clinical therapies for chronic allergic airways diseases, such as asthma." | 3.96 | Investigation of molecular mechanisms of experimental compounds in murine models of chronic allergic airways disease using synchrotron Fourier-transform infrared microspectroscopy. ( Bambery, KR; Karagiannis, TC; Licciardi, PV; Mazarakis, N; Royce, SG; Samuel, CS; Snibson, KJ; Tobin, MJ; Ververis, K; Vongsvivut, J, 2020) |
| "Valproic acid treatment did not affect inflammation parameters; however, valproic acid treatment resulted in reduced epithelial thickness as compared to vehicle treated mice (p < 0." | 1.37 | Protective effects of valproic acid against airway hyperresponsiveness and airway remodeling in a mouse model of allergic airways disease. ( Dang, W; De Sampayo, N; El-Osta, A; Karagiannis, TC; Royce, SG; Tang, ML; Ververis, K, 2011) |
| "Three times acute cardiopulmonary arrest appeared during status asthmaticus." | 1.33 | [Lance-Adams syndrome in patient with anoxic encephalopathy in the course of bronchial asthma]. ( Budrewicz, SP; Koszewicz, MA; Kowalczyk, EE; Podemski, R; Słotwiński, K, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mazarakis, N | 1 |
| Vongsvivut, J | 1 |
| Bambery, KR | 1 |
| Ververis, K | 2 |
| Tobin, MJ | 1 |
| Royce, SG | 2 |
| Samuel, CS | 1 |
| Snibson, KJ | 1 |
| Licciardi, PV | 1 |
| Karagiannis, TC | 2 |
| Dang, W | 1 |
| De Sampayo, N | 1 |
| El-Osta, A | 1 |
| Tang, ML | 1 |
| Kowalczyk, EE | 1 |
| Koszewicz, MA | 1 |
| Budrewicz, SP | 1 |
| Podemski, R | 1 |
| Słotwiński, K | 1 |
| Sirén, A | 1 |
| Kylliäinen, A | 1 |
| Tenhunen, M | 1 |
| Hirvonen, K | 1 |
| Riita, T | 1 |
| Koivikko, M | 1 |
| Czuczwar, SJ | 1 |
| Gasior, M | 1 |
| Kozicka, M | 1 |
| Pietrasiewicz, T | 1 |
| Turski, WA | 1 |
| Kleinrok, Z | 1 |
1 trial available for valproic acid and Asthma
| Article | Year |
|---|---|
Beneficial effects of antiepileptic medication on absence seizures and cognitive functioning in children.
Topics: Adolescent; Anticonvulsants; Asthma; Attention; Child; Child, Preschool; Cognition; Discrimination, | 2007 |
4 other studies available for valproic acid and Asthma
| Article | Year |
|---|---|
Investigation of molecular mechanisms of experimental compounds in murine models of chronic allergic airways disease using synchrotron Fourier-transform infrared microspectroscopy.
Topics: Animals; Anti-Asthmatic Agents; Asthma; Chronic Disease; Disease Models, Animal; Drug Evaluation, Pr | 2020 |
Protective effects of valproic acid against airway hyperresponsiveness and airway remodeling in a mouse model of allergic airways disease.
Topics: Airway Remodeling; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease | 2011 |
[Lance-Adams syndrome in patient with anoxic encephalopathy in the course of bronchial asthma].
Topics: Adult; Asthma; Cardiopulmonary Resuscitation; Diagnosis, Differential; Electroencephalography; Femal | 2006 |
Influence of a potential anti-asthmatic drug, CR 2039, upon the anticonvulsive activity of conventional antiepileptics against maximal electroshock-induced seizures in mice.
Topics: Animals; Anticonvulsants; Asthma; Avoidance Learning; Benzamides; Bronchodilator Agents; Carbamazepi | 1996 |