valproic acid has been researched along with As If Personality in 12 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The anticonvulsants valproate and topiramate appeared to have the most empirical support for having a favorable effect on symptoms of borderline personality disorder." | 4.85 | [Empirical evidence for the use of anticonvulsants in personality disorders]. ( Emrich, HM; Sieberer, M, 2009) |
| "This 12-month, prospective, observational study investigated factors associated with symptomatic remission (total YMRS score < or =12) and full clinical recovery (sustained reduction in CGI-BP-S overall score) in bipolar disorder during treatment with atypical antipsychotics (predominantly olanzapine, risperidone and quetiapine; alone or in combination with a psychotropic such as lithium or valproate) in actual clinical practice." | 3.76 | Twelve-month prospective, multinational, observational study of factors associated with recovery from mania in bipolar disorder in patients treated with atypical antipsychotics. ( Badr, MG; D'yachkova, Y; Dikeos, D; Fábián, Z; Harrison, G; Hudiţă, C; Okasha, T; Pesek, MB; Tapia-Paniagua, G; Treuer, T; Yang, F, 2010) |
| "An experimental and clinico-pharmacological study of sodium valproate, a GABA-ergic drug, was conducted to elucidate the role of gamma-aminobutyric acid in the mechanisms responsible for affective disturbances, in particular for anxiety." | 3.67 | [Anxiolytic action of sodium valproate (possible role of gamma-aminobutyric acid in affective disorders)]. ( Aleksandrovskiĭ, IuA; Kharlamov, AN; Neznamov, GG; Poiurovskiĭ, MV; Raevskiĭ, KS, 1985) |
| "Fifty-two outpatients with DSM-IV borderline personality disorder were randomly assigned to receive divalproex (N=20) or placebo (N=32), double-blind, for 12 weeks." | 2.71 | Impact of trait impulsivity and state aggression on divalproex versus placebo response in borderline personality disorder. ( Coccaro, EF; Hollander, E; Jiang, P; Smith, TB; Swann, AC, 2005) |
| " Divalproex sodium was increased as tolerated using a flexible dosing schedule." | 2.69 | Divalproex sodium for impulsive aggressive behavior in patients with personality disorder. ( Coccaro, EF; Kavoussi, RJ, 1998) |
| "Early treatment of epilepsy is warranted to avoid possible severe consequences." | 1.39 | Epilepsy and brain injury: a case report of a dramatic neuropsychiatric vicious circle. ( Angeletti, G; Carbonetti, P; Del Casale, A; Fensore, C; Ferracuti, S; Girardi, P; Kotzalidis, GD; Lazanio, S; Muzi, A; Rapinesi, C; Savoja, V; Scatena, P; Serata, D; Tatarelli, R, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (16.67) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rapinesi, C | 1 |
| Del Casale, A | 1 |
| Serata, D | 1 |
| Kotzalidis, GD | 2 |
| Scatena, P | 1 |
| Muzi, A | 1 |
| Lazanio, S | 1 |
| Savoja, V | 2 |
| Carbonetti, P | 1 |
| Fensore, C | 1 |
| Ferracuti, S | 2 |
| Angeletti, G | 2 |
| Tatarelli, R | 2 |
| Girardi, P | 2 |
| Sieberer, M | 1 |
| Emrich, HM | 1 |
| Dikeos, D | 1 |
| Badr, MG | 1 |
| Yang, F | 1 |
| Pesek, MB | 1 |
| Fábián, Z | 1 |
| Tapia-Paniagua, G | 1 |
| Hudiţă, C | 1 |
| Okasha, T | 1 |
| D'yachkova, Y | 1 |
| Harrison, G | 1 |
| Treuer, T | 1 |
| Sani, G | 1 |
| De Rossi, P | 1 |
| Stefani, S | 1 |
| Pancheri, L | 1 |
| Santucci, C | 1 |
| Roma, P | 1 |
| Simonetti, A | 1 |
| Ambrosi, E | 1 |
| Comparelli, A | 1 |
| Manfredi, G | 1 |
| Hollander, E | 2 |
| Tracy, KA | 1 |
| Swann, AC | 2 |
| Coccaro, EF | 3 |
| McElroy, SL | 1 |
| Wozniak, P | 1 |
| Sommerville, KW | 1 |
| Nemeroff, CB | 1 |
| Barkai, G | 1 |
| Goshen, E | 1 |
| Tzila Zwas, S | 1 |
| Dolberg, OT | 1 |
| Pick, CG | 1 |
| Bonne, O | 1 |
| Schreiber, S | 1 |
| Jiang, P | 1 |
| Smith, TB | 1 |
| Yatham, LN | 1 |
| Kennedy, SH | 1 |
| O'Donovan, C | 1 |
| Parikh, S | 1 |
| MacQueen, G | 1 |
| McIntyre, R | 1 |
| Sharma, V | 1 |
| Silverstone, P | 1 |
| Alda, M | 1 |
| Baruch, P | 1 |
| Beaulieu, S | 1 |
| Daigneault, A | 1 |
| Milev, R | 1 |
| Young, LT | 1 |
| Ravindran, A | 1 |
| Schaffer, A | 1 |
| Connolly, M | 1 |
| Gorman, CP | 1 |
| Deltito, JA | 1 |
| Kavoussi, RJ | 1 |
| Deisenhammer, E | 1 |
| Raevskiĭ, KS | 1 |
| Aleksandrovskiĭ, IuA | 1 |
| Poiurovskiĭ, MV | 1 |
| Kharlamov, AN | 1 |
| Neznamov, GG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double-blind, Double-dummy, Controlled Trial of Lithium Versus Paroxetine in Subjects With Major Depression Who Have a Family History of Bipolar Disorder or Completed Suicide - a Pilot Study[NCT00400088] | Phase 3 | 2 participants (Actual) | Interventional | 2007-06-30 | Terminated (stopped due to Recruitment difficulties) | ||
| Light-Therapy in the Treatment of the Acute Phase of the Bipolar Type II Depression: Double-Blind, Placebo-Controlled Study to Establish Efficacy and Safety[NCT00590265] | 50 participants (Anticipated) | Interventional | 2008-01-31 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for valproic acid and As If Personality
| Article | Year |
|---|---|
[Empirical evidence for the use of anticonvulsants in personality disorders].
Topics: Amines; Anticonvulsants; Borderline Personality Disorder; Carbamazepine; Cyclohexanecarboxylic Acids | 2009 |
Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patients with bipolar disorder: consensus and controversies.
Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Antipsychotic Agents; Anxiety Disorders; Benzodiaz | 2005 |
Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patients with bipolar disorder: consensus and controversies.
Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Antipsychotic Agents; Anxiety Disorders; Benzodiaz | 2005 |
Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patients with bipolar disorder: consensus and controversies.
Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Antipsychotic Agents; Anxiety Disorders; Benzodiaz | 2005 |
Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patients with bipolar disorder: consensus and controversies.
Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Antipsychotic Agents; Anxiety Disorders; Benzodiaz | 2005 |
4 trials available for valproic acid and As If Personality
| Article | Year |
|---|---|
Divalproex in the treatment of impulsive aggression: efficacy in cluster B personality disorders.
Topics: Adult; Aged; Aggression; Analysis of Variance; Chi-Square Distribution; Double-Blind Method; Female; | 2003 |
Impact of trait impulsivity and state aggression on divalproex versus placebo response in borderline personality disorder.
Topics: Adult; Age of Onset; Aggression; Anticonvulsants; Borderline Personality Disorder; Double-Blind Meth | 2005 |
Divalproex sodium for impulsive aggressive behavior in patients with personality disorder.
Topics: Adult; Aggression; Anticonvulsants; Antimanic Agents; Female; Fluoxetine; Humans; Impulsive Behavior | 1998 |
[Modification of personality changes in epileptics using dipropylacetate (Convulex). Preliminary communication].
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Clinical Trials as Topic; Drug Evaluation; Epi | 1977 |
6 other studies available for valproic acid and As If Personality
| Article | Year |
|---|---|
Epilepsy and brain injury: a case report of a dramatic neuropsychiatric vicious circle.
Topics: Accidents, Traffic; Aggression; Amines; Anterior Temporal Lobectomy; Anticonvulsants; Brain Injuries | 2013 |
Twelve-month prospective, multinational, observational study of factors associated with recovery from mania in bipolar disorder in patients treated with atypical antipsychotics.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Comorbidity; Diagnostic and Statisti | 2010 |
Bipolar disorder presenting as stalking--a case report.
Topics: Anticonvulsants; Antimanic Agents; Bipolar Disorder; Cognitive Behavioral Therapy; Combined Modality | 2011 |
Acetazolamide-enhanced neuroSPECT scan reveals functional impairment after minimal traumatic brain injury not otherwise discernible.
Topics: Acetazolamide; Adult; Brain; Brain Injuries; Carbonic Anhydrase Inhibitors; Cognition Disorders; Hum | 2004 |
The effect of valproate on bipolar spectrum temperamental disorders.
Topics: Adult; Bipolar Disorder; Cyclothymic Disorder; Female; Humans; Male; Middle Aged; Personality Disord | 1993 |
[Anxiolytic action of sodium valproate (possible role of gamma-aminobutyric acid in affective disorders)].
Topics: Adult; Animals; Anti-Anxiety Agents; Anxiety; Brain; Cats; Female; gamma-Aminobutyric Acid; Humans; | 1985 |