valproic acid has been researched along with Arachnoidal Cerebellar Sarcoma, Circumscribed in 9 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Excerpt | Relevance | Reference |
---|---|---|
"Histone deacetylate inhibitors (HDACi), as valproic acid (VA), have been reported to enhance efficacy and to prevent drug resistance in some tumors, including medulloblastoma (MB)." | 7.88 | Valproic acid treatment response in vitro is determined by TP53 status in medulloblastoma. ( Cavalheiro, S; Dastoli, P; Mascaro-Cordeiro, B; Oliveira, ID; Pavon, LF; Saba-Silva, N; Tesser-Gamba, F; Toledo, SRC, 2018) |
"To develop novel orthotopic xenograft models of medulloblastoma in severe combined immunodeficient mice and to evaluate the in vivo antitumor efficacy of valproic acid." | 7.73 | Valproic Acid prolongs survival time of severe combined immunodeficient mice bearing intracerebellar orthotopic medulloblastoma xenografts. ( Adesina, A; Antalffy, B; Blaney, SM; Lau, CC; Li, XN; Ou, CN; Pietsch, T; Shu, Q; Su, JM, 2006) |
"Valproic acid is a well-tolerated anticonvulsant that has been identified recently as a histone deacetylase inhibitor." | 5.33 | Valproic acid induces growth arrest, apoptosis, and senescence in medulloblastomas by increasing histone hyperacetylation and regulating expression of p21Cip1, CDK4, and CMYC. ( Blaney, SM; Lau, CC; Li, XN; Perlaky, L; Shu, Q; Su, JM, 2005) |
"Histone deacetylate inhibitors (HDACi), as valproic acid (VA), have been reported to enhance efficacy and to prevent drug resistance in some tumors, including medulloblastoma (MB)." | 3.88 | Valproic acid treatment response in vitro is determined by TP53 status in medulloblastoma. ( Cavalheiro, S; Dastoli, P; Mascaro-Cordeiro, B; Oliveira, ID; Pavon, LF; Saba-Silva, N; Tesser-Gamba, F; Toledo, SRC, 2018) |
" The authors evaluated the cytotoxicity of histone deacetylase inhibitors (HDI) [MS-275, SAHA, TSA, M344, M360, D85, SW55, SW187 and valproic acid (VPA)] on 13 embryonal tumor cell lines [4 medulloblastomas, 5 neuroblastomas, 2 atypical teratoid/rhabdoid tumors (AT/RT), and 2 malignant rhabdoid tumors of the kidney (RTK)] in MTT assay." | 3.74 | Inhibitors of histone deacetylases as potential therapeutic tools for high-risk embryonal tumors of the nervous system of childhood. ( Frühwald, MC; Furchert, SE; Jung, M; Juürgens, H; Lanvers-Kaminsky, C; Loidl, A, 2007) |
"To develop novel orthotopic xenograft models of medulloblastoma in severe combined immunodeficient mice and to evaluate the in vivo antitumor efficacy of valproic acid." | 3.73 | Valproic Acid prolongs survival time of severe combined immunodeficient mice bearing intracerebellar orthotopic medulloblastoma xenografts. ( Adesina, A; Antalffy, B; Blaney, SM; Lau, CC; Li, XN; Ou, CN; Pietsch, T; Shu, Q; Su, JM, 2006) |
"Medulloblastoma is the most common malignant brain tumor in children." | 1.43 | Successful Use of Dose Dense Neoadjuvant Chemotherapy and Sodium Valproate with Minimal Toxicity in an Infant with Medulloblastoma in Extremely Poor General Condition. ( Abrari, A; Gupta, A; Kumar, A; Patir, R; Vaishya, S, 2016) |
"Valproic acid is a well-tolerated anticonvulsant that has been identified recently as a histone deacetylase inhibitor." | 1.33 | Valproic acid induces growth arrest, apoptosis, and senescence in medulloblastomas by increasing histone hyperacetylation and regulating expression of p21Cip1, CDK4, and CMYC. ( Blaney, SM; Lau, CC; Li, XN; Perlaky, L; Shu, Q; Su, JM, 2005) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 5 (55.56) | 29.6817 |
2010's | 4 (44.44) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Mascaro-Cordeiro, B | 1 |
Oliveira, ID | 1 |
Tesser-Gamba, F | 1 |
Pavon, LF | 1 |
Saba-Silva, N | 1 |
Cavalheiro, S | 1 |
Dastoli, P | 1 |
Toledo, SRC | 1 |
Patties, I | 2 |
Kortmann, RD | 2 |
Glasow, A | 2 |
Menzel, F | 1 |
Gupta, A | 1 |
Kumar, A | 1 |
Abrari, A | 1 |
Patir, R | 1 |
Vaishya, S | 1 |
Ecke, I | 1 |
Petry, F | 1 |
Rosenberger, A | 1 |
Tauber, S | 1 |
Mönkemeyer, S | 1 |
Hess, I | 1 |
Dullin, C | 1 |
Kimmina, S | 1 |
Pirngruber, J | 1 |
Johnsen, SA | 1 |
Uhmann, A | 1 |
Nitzki, F | 1 |
Wojnowski, L | 1 |
Schulz-Schaeffer, W | 1 |
Witt, O | 1 |
Hahn, H | 1 |
Häcker, S | 1 |
Dittrich, A | 1 |
Mohr, A | 1 |
Schweitzer, T | 1 |
Rutkowski, S | 1 |
Krauss, J | 1 |
Debatin, KM | 1 |
Fulda, S | 1 |
Li, XN | 2 |
Shu, Q | 2 |
Su, JM | 2 |
Perlaky, L | 1 |
Blaney, SM | 2 |
Lau, CC | 2 |
Antalffy, B | 1 |
Adesina, A | 1 |
Ou, CN | 1 |
Pietsch, T | 1 |
Furchert, SE | 1 |
Lanvers-Kaminsky, C | 1 |
Juürgens, H | 1 |
Jung, M | 1 |
Loidl, A | 1 |
Frühwald, MC | 1 |
9 other studies available for valproic acid and Arachnoidal Cerebellar Sarcoma, Circumscribed
Article | Year |
---|---|
Valproic acid treatment response in vitro is determined by TP53 status in medulloblastoma.
Topics: Cell Line, Tumor; Cell Survival; Cerebellar Neoplasms; Dose-Response Relationship, Drug; Genetic Var | 2018 |
Inhibitory effects of epigenetic modulators and differentiation inducers on human medulloblastoma cell lines.
Topics: Antineoplastic Agents; Azacitidine; Cell Line, Tumor; Cell Proliferation; Cerebellar Neoplasms; Deci | 2013 |
Enhanced inhibition of clonogenic survival of human medulloblastoma cells by multimodal treatment with ionizing irradiation, epigenetic modifiers, and differentiation-inducing drugs.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cell Di | 2016 |
Successful Use of Dose Dense Neoadjuvant Chemotherapy and Sodium Valproate with Minimal Toxicity in an Infant with Medulloblastoma in Extremely Poor General Condition.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cerebellar Neoplasms; Child; Child, Pre | 2016 |
Antitumor effects of a combined 5-aza-2'deoxycytidine and valproic acid treatment on rhabdomyosarcoma and medulloblastoma in Ptch mutant mice.
Topics: Acetylation; Animals; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Decitabine; DNA ( | 2009 |
Histone deacetylase inhibitors cooperate with IFN-gamma to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8.
Topics: Benzamides; Caspase 8; Cell Line, Tumor; Cell Survival; Cerebellar Neoplasms; Drug Combinations; Dru | 2009 |
Valproic acid induces growth arrest, apoptosis, and senescence in medulloblastomas by increasing histone hyperacetylation and regulating expression of p21Cip1, CDK4, and CMYC.
Topics: Acetylation; Animals; Apoptosis; Blotting, Western; Cell Cycle; Cell Division; Cell Line, Tumor; Cel | 2005 |
Valproic Acid prolongs survival time of severe combined immunodeficient mice bearing intracerebellar orthotopic medulloblastoma xenografts.
Topics: Animals; Carcinogenicity Tests; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cell Sur | 2006 |
Inhibitors of histone deacetylases as potential therapeutic tools for high-risk embryonal tumors of the nervous system of childhood.
Topics: Acetylation; Annexin A5; Apoptosis; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Enzyme Inh | 2007 |