valproic acid has been researched along with Anemia, Aplastic in 6 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Anemia, Aplastic: A form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The side effects and possible side effects of the therapy with valproic acid were documented in 66 outpatients with epilepsy over a period of one year." | 3.66 | [Antiepileptic therapy with valproinic acid. Correlations of side effects and serum levels of valproinic acid]. ( Fröscher, W; Gugler, R; Schulz, HU, 1979) |
| "Rare, serious adverse effects of antiepileptic drugs (AEDs) include hepatotoxicity and bone marrow suppression." | 2.38 | Routine laboratory monitoring for serious adverse effects of antiepileptic medications: the controversy. ( Wyllie, E; Wyllie, R, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Handoko, KB | 1 |
| Souverein, PC | 1 |
| van Staa, TP | 1 |
| Meyboom, RH | 1 |
| Leufkens, HG | 1 |
| Egberts, TC | 1 |
| van den Bemt, PM | 1 |
| Zaccara, G | 1 |
| Franciotta, D | 1 |
| Perucca, E | 1 |
| MacDougall, LG | 1 |
| Fröscher, W | 1 |
| Schulz, HU | 1 |
| Gugler, R | 1 |
| Wyllie, E | 1 |
| Wyllie, R | 1 |
| Nathan, D | 1 |
| Guillon, JL | 1 |
| Chevallier, B | 1 |
| Gallet, JP | 1 |
2 reviews available for valproic acid and Anemia, Aplastic
| Article | Year |
|---|---|
Idiosyncratic adverse reactions to antiepileptic drugs.
Topics: Age Factors; Anemia, Aplastic; Anticonvulsants; B-Lymphocytes; Central Nervous System Diseases; Chem | 2007 |
Routine laboratory monitoring for serious adverse effects of antiepileptic medications: the controversy.
Topics: Anemia, Aplastic; Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury; Drug Monit | 1991 |
4 other studies available for valproic acid and Anemia, Aplastic
| Article | Year |
|---|---|
Risk of aplastic anemia in patients using antiepileptic drugs.
Topics: Adult; Aged; Aged, 80 and over; Anemia, Aplastic; Anticonvulsants; Carbamazepine; Case-Control Studi | 2006 |
Pure red cell aplasia associated with sodium valproate therapy.
Topics: Anemia, Aplastic; Chickenpox; Child; Female; Humans; Measles; Psychotherapy; Seizures; Time Factors; | 1982 |
[Antiepileptic therapy with valproinic acid. Correlations of side effects and serum levels of valproinic acid].
Topics: Acne Vulgaris; Anemia, Aplastic; Epilepsy; Fatigue; Gastrointestinal Diseases; Humans; Leukopenia; T | 1979 |
[Thrombopenia and erythroblastopenia in a 1-month-old infant treated with valproate].
Topics: Anemia, Aplastic; Humans; Infant; Male; Purpura, Thrombocytopenic; Valproic Acid | 1987 |