valproic acid has been researched along with Anaplastic Astrocytoma in 11 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Inositol uptake was measured at concentrations of 25, 40 and 50 microM in human astrocytoma cell cultures treated for 1-3 weeks with pharmacologically relevant concentrations of LiCl, valproic acid or carbamazepine as well as in control cultures that had not been treated with any drug." | 7.70 | Chronic treatment of human astrocytoma cells with lithium, carbamazepine or valproic acid decreases inositol uptake at high inositol concentrations but increases it at low inositol concentrations. ( Belmaker, RH; Bersudsky, Y; Hertz, L; Simkin, M; Wolfson, M; Zinger, E, 2000) |
| " The authors examined the effect of VPA at therapeutic concentrations (300 and 600 microM) on the elevation of intracellular free calcium concentration ([Ca(2+)](i)) induced by carbachol, a muscarinic receptor agonist, in 1321N1 human astrocytoma cells." | 3.74 | Sodium valproate at therapeutic concentrations changes Ca2+ response accompanied with its weak inhibition of protein kinase C in human astrocytoma cells. ( Kurita, M; Mashiko, H; Nakahata, N; Nishino, S; Niwa, S; Ohtomo, K; Rai, M; Shirakawa, H, 2007) |
| "Inositol uptake was measured at concentrations of 25, 40 and 50 microM in human astrocytoma cell cultures treated for 1-3 weeks with pharmacologically relevant concentrations of LiCl, valproic acid or carbamazepine as well as in control cultures that had not been treated with any drug." | 3.70 | Chronic treatment of human astrocytoma cells with lithium, carbamazepine or valproic acid decreases inositol uptake at high inositol concentrations but increases it at low inositol concentrations. ( Belmaker, RH; Bersudsky, Y; Hertz, L; Simkin, M; Wolfson, M; Zinger, E, 2000) |
| "Valproic acid (VPA) has been recently investigated for its anticancer properties in different tumors, including malignant gliomas." | 1.34 | Valproic acid increases the in vitro effects of nitrosureas on human glioma cell lines. ( Balzarotti, M; Boiardi, A; Calatozzolo, C; Ciusani, E; Croci, D; de Grazia, U; Salmaggi, A, 2007) |
| "The case of a 12-year-old boy with anaplastic astrocytoma of the left thalamus is reported." | 1.33 | Combined treatment of pediatric high-grade glioma with the oncolytic viral strain MTH-68/H and oral valproic acid. ( Csatary, CM; Csatary, LK; Gosztonyi, G; Hartmann, C; Hernáiz-Driever, P; Koch, HC; Längler, A; Peters, O; Théallier-Janko, A; Wagner, S; Wolff, JE; Zintl, F, 2006) |
| "Right hemispheric brain tumors involving the orbitofrontal or basotemporal cortex are a rare cause of secondary mania." | 1.32 | Exacerbation of mania secondary to right temporal lobe astrocytoma in a bipolar patient previously stabilized on valproate. ( Denson, TF; Sokolski, KN, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 7 (63.64) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lamarre, M | 1 |
| Desrosiers, RR | 1 |
| Fisch, L | 1 |
| Mégevand, P | 1 |
| Badoud, S | 1 |
| Badoud, A | 1 |
| Seeck, M | 1 |
| Burkhard, PR | 1 |
| Sokolski, KN | 1 |
| Denson, TF | 1 |
| Wagner, S | 1 |
| Csatary, CM | 1 |
| Gosztonyi, G | 1 |
| Koch, HC | 1 |
| Hartmann, C | 1 |
| Peters, O | 1 |
| Hernáiz-Driever, P | 1 |
| Théallier-Janko, A | 1 |
| Zintl, F | 1 |
| Längler, A | 1 |
| Wolff, JE | 1 |
| Csatary, LK | 1 |
| Kurita, M | 1 |
| Nishino, S | 1 |
| Ohtomo, K | 1 |
| Rai, M | 1 |
| Shirakawa, H | 1 |
| Mashiko, H | 1 |
| Niwa, S | 1 |
| Nakahata, N | 1 |
| Ciusani, E | 1 |
| Balzarotti, M | 1 |
| Calatozzolo, C | 1 |
| de Grazia, U | 1 |
| Boiardi, A | 1 |
| Salmaggi, A | 1 |
| Croci, D | 1 |
| Hennessy, MJ | 1 |
| Wiles, CM | 1 |
| Cortés, V | 1 |
| Landete, L | 1 |
| Gómez, E | 1 |
| Blasco, R | 1 |
| Wolfson, M | 1 |
| Bersudsky, Y | 1 |
| Zinger, E | 1 |
| Simkin, M | 1 |
| Belmaker, RH | 1 |
| Hertz, L | 1 |
| Proulle, V | 1 |
| Masnou, P | 1 |
| Cartron, J | 1 |
| Kaplan, C | 1 |
| Ajzenberg, N | 1 |
| Tchernia, G | 1 |
| Dreyfus, M | 1 |
| Gensburger, C | 1 |
| Simler, S | 1 |
| Ciesielski, L | 1 |
| Mandel, P | 1 |
11 other studies available for valproic acid and Anaplastic Astrocytoma
| Article | Year |
|---|---|
Up-regulation of protein L-isoaspartyl methyltransferase expression by lithium is mediated by glycogen synthase kinase-3 inactivation and beta-catenin stabilization.
Topics: Adjuvants, Immunologic; Astrocytoma; beta Catenin; Cell Line, Tumor; Dose-Response Relationship, Dru | 2008 |
Pilomotor seizure: when paroxysmal gooseflesh heralds brain tumor.
Topics: Aged; Amygdala; Anticonvulsants; Astrocytoma; Brain Neoplasms; Electroencephalography; Hippocampus; | 2012 |
Exacerbation of mania secondary to right temporal lobe astrocytoma in a bipolar patient previously stabilized on valproate.
Topics: Anticonvulsants; Antimanic Agents; Astrocytoma; Bipolar Disorder; Brain Neoplasms; Disease Progressi | 2003 |
Combined treatment of pediatric high-grade glioma with the oncolytic viral strain MTH-68/H and oral valproic acid.
Topics: Administration, Oral; Anticonvulsants; Antigens, Viral; Astrocytoma; Brain; Brain Neoplasms; Child; | 2006 |
Sodium valproate at therapeutic concentrations changes Ca2+ response accompanied with its weak inhibition of protein kinase C in human astrocytoma cells.
Topics: Astrocytoma; Binding, Competitive; Calcium; Carbachol; Cell Line, Tumor; Cell Membrane; Cholinergic | 2007 |
Valproic acid increases the in vitro effects of nitrosureas on human glioma cell lines.
Topics: Acetylation; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Astrocytoma; Carmustine; Cel | 2007 |
Lamotrigine encephalopathy.
Topics: Anticonvulsants; Astrocytoma; Brain Diseases; Brain Neoplasms; Drug Interactions; Female; Frontal Lo | 1996 |
[Partial simple vegetative crisis: importance of electroencephalographic findings].
Topics: Anticonvulsants; Astrocytoma; Brain Neoplasms; Electroencephalography; Epilepsies, Partial; Female; | 1997 |
Chronic treatment of human astrocytoma cells with lithium, carbamazepine or valproic acid decreases inositol uptake at high inositol concentrations but increases it at low inositol concentrations.
Topics: Antimanic Agents; Astrocytoma; Bipolar Disorder; Brain; Brain Neoplasms; Carbamazepine; Dose-Respons | 2000 |
GPIaIIa as a candidate target for anti-platelet autoantibody occurring during valproate therapy and associated with peroperative bleeding.
Topics: Adult; Anticonvulsants; Astrocytoma; Autoantibodies; Blood Platelets; Brain Neoplasms; Female; Hemor | 2000 |
[Effect of sodium n-dipropylacetate (sodium valproate) on GABA level of neuronal and glial cells in culture].
Topics: Animals; Astrocytoma; Bucladesine; Cell Line; gamma-Aminobutyric Acid; Kinetics; Neuroblastoma; Rats | 1978 |