valproic acid has been researched along with Amino Acid Metabolism Disorders, Inborn in 17 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "There are multiple genetic links between schizophrenia and a deficit of proline dehydrogenase (PRODH) enzyme activity." | 7.77 | Evidence for association of hyperprolinemia with schizophrenia and a measure of clinical outcome. ( Baraldi, AN; Bart, CP; Clelland, CL; Clelland, JD; Nadrich, RH; Panek, LJ; Pappas, CA; Read, LL, 2011) |
| "Valproic acid induced coma is presented in an adult patient without a history of metabolic disease." | 7.68 | Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma. ( Colombo, JP; Straver, JS; van der Vijver, JC; van Woerkom, TC; Verbiest, HB, 1992) |
| "There are multiple genetic links between schizophrenia and a deficit of proline dehydrogenase (PRODH) enzyme activity." | 3.77 | Evidence for association of hyperprolinemia with schizophrenia and a measure of clinical outcome. ( Baraldi, AN; Bart, CP; Clelland, CL; Clelland, JD; Nadrich, RH; Panek, LJ; Pappas, CA; Read, LL, 2011) |
| "Valproic acid induced coma is presented in an adult patient without a history of metabolic disease." | 3.68 | Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma. ( Colombo, JP; Straver, JS; van der Vijver, JC; van Woerkom, TC; Verbiest, HB, 1992) |
| "Thus carnitine is an infrequent problem in the healthy, well nourished adult population in the United States." | 2.37 | Carnitine as an essential nutrient. ( Bennett, SG; Borum, PR, 1986) |
| "Ornithine transcarbamylase deficiency is an X linked disorder and the most common inherited cause of hyperammonaemia." | 1.30 | Hyperammonaemic encephalopathy after initiation of valproate therapy in unrecognised ornithine transcarbamylase deficiency. ( Kohlschütter, A; Oechsner, M; Steen, C; Stürenburg, HJ, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (47.06) | 18.7374 |
| 1990's | 4 (23.53) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 1 (5.88) | 24.3611 |
| 2020's | 3 (17.65) | 2.80 |
| Authors | Studies |
|---|---|
| Armstrong, AJ | 1 |
| Henke, BR | 1 |
| Collado, MS | 1 |
| Taylor, JM | 1 |
| Pourtaheri, TD | 1 |
| Dillberger, JE | 1 |
| Roper, TD | 1 |
| Wamhoff, BR | 1 |
| Olson, MW | 1 |
| Figler, RA | 1 |
| Hoang, SA | 1 |
| Reardon, JE | 1 |
| Johns, BA | 1 |
| McCarron, EP | 1 |
| Colijn, MA | 1 |
| Clelland, CL | 1 |
| Read, LL | 1 |
| Baraldi, AN | 1 |
| Bart, CP | 1 |
| Pappas, CA | 1 |
| Panek, LJ | 1 |
| Nadrich, RH | 1 |
| Clelland, JD | 1 |
| Tripp, JH | 1 |
| Hargreaves, T | 1 |
| Anthony, PP | 1 |
| Searle, JF | 1 |
| Miller, P | 1 |
| Leonard, JV | 1 |
| Patrick, AD | 1 |
| Oberholzer, VG | 1 |
| Divry, P | 1 |
| Baltassat, P | 1 |
| Rolland, MO | 1 |
| Cotte, J | 1 |
| Hermier, M | 1 |
| Duran, M | 1 |
| Wadman, SK | 1 |
| Oka, S | 1 |
| Igarashi, Y | 1 |
| Narisawa, K | 1 |
| Tada, K | 1 |
| Batshaw, ML | 1 |
| Brusilow, SW | 1 |
| Sewell, AC | 1 |
| Böhles, HJ | 1 |
| Herwig, J | 1 |
| Demirkol, M | 1 |
| Oechsner, M | 1 |
| Steen, C | 1 |
| Stürenburg, HJ | 1 |
| Kohlschütter, A | 1 |
| Jung, P | 1 |
| Doussard-Lefaucheux, S | 1 |
| Verbiest, HB | 1 |
| Straver, JS | 1 |
| Colombo, JP | 2 |
| van der Vijver, JC | 1 |
| van Woerkom, TC | 1 |
| Christmann, D | 1 |
| Hirsch, E | 1 |
| Mutschler, V | 1 |
| Collard, M | 1 |
| Marescaux, C | 1 |
| Kay, JD | 1 |
| Hilton-Jones, D | 1 |
| Hyman, N | 1 |
| Bourrier, P | 1 |
| Varache, N | 1 |
| Alquier, P | 1 |
| Rabier, D | 1 |
| Kamoun, P | 1 |
| Lorre, G | 1 |
| Alhayek, G | 1 |
| Borum, PR | 1 |
| Bennett, SG | 1 |
| Morgan, HB | 1 |
| Swaiman, KF | 1 |
| Johnson, BD | 1 |
3 reviews available for valproic acid and Amino Acid Metabolism Disorders, Inborn
| Article | Year |
|---|---|
The characterization of psychotic symptoms in succinic semialdehyde dehydrogenase deficiency: a review.
Topics: Adolescent; Age of Onset; Aggression; Amino Acid Metabolism, Inborn Errors; Anticonvulsants; Anxiety | 2020 |
[Late diagnosis of congenital argininemia during administration of sodium valproate].
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Ammonia; Arginine; Epilepsy; Female; Humans; Psych | 1990 |
Carnitine as an essential nutrient.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Biological Transport; Carnitine; Diet; Energy Metabolis | 1986 |
14 other studies available for valproic acid and Amino Acid Metabolism Disorders, Inborn
| Article | Year |
|---|---|
Identification of 2,2-Dimethylbutanoic Acid (HST5040), a Clinical Development Candidate for the Treatment of Propionic Acidemia and Methylmalonic Acidemia.
Topics: Acyl Coenzyme A; Amino Acid Metabolism, Inborn Errors; Animals; Area Under Curve; Butyrates; Cells, | 2021 |
Valproate induced carnitine deficiency and hyperammonaemia.
Topics: Amino Acid Metabolism, Inborn Errors; Anticonvulsants; Carnitine; Epilepsy; Humans; Hyperammonemia; | 2023 |
Evidence for association of hyperprolinemia with schizophrenia and a measure of clinical outcome.
Topics: 1-Pyrroline-5-Carboxylate Dehydrogenase; Adolescent; Adult; Aged; Amino Acid Metabolism, Inborn Erro | 2011 |
Sodium valproate and ornithine carbamyl transferase deficiency.
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Humans; Infant; Liver; Male; Mitochondria, Liver; Orn | 1981 |
A new patient with 4-hydroxybutyric aciduria, a possible defect of 4-aminobutyrate metabolism.
Topics: Amino Acid Metabolism, Inborn Errors; Child; Child, Preschool; gamma-Aminobutyric Acid; Glutamates; | 1983 |
[Case of propionic acidemia].
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Female; Humans; Infant; Propionates; Valproic Acid | 1984 |
Valproate-induced hyperammonemia.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Ammonia; Anticonvulsants; Carbamoyl-Phosphate Synt | 1982 |
Neurological deterioration in patients with urea cycle disorders under valproate therapy--a cause for concern.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Ammonia; Arginine; Child; Epilepsy; Female; Humans | 1995 |
Hyperammonaemic encephalopathy after initiation of valproate therapy in unrecognised ornithine transcarbamylase deficiency.
Topics: Adolescent; Amino Acid Metabolism, Inborn Errors; Ammonia; Anticonvulsants; Brain Diseases, Metaboli | 1998 |
[Visual field defect in a patient given sodium valporate then carbamazepine: possible effect of aminotransferase inhibition].
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Anticonvulsants; Carbamazepine; Drug Therapy, Combinati | 2002 |
Carbamyl phosphate synthetase-1 deficiency discovered after valproic acid-induced coma.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Ammonia; Atrophy; Carbamoyl-Phosphate Synthase (Ammonia | 1992 |
Valproate toxicity and ornithine carbamoyltransferase deficiency.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Female; Humans; Ornithine Carbamoyltransferase Deficien | 1986 |
[Cerebral edema with hyperammonemia in valpromide poisoning. Manifestation in an adult, of a partial deficit in type I carbamylphosphate synthetase].
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Ammonia; Anticonvulsants; Brain Edema; Carbamoyl-Phosph | 1988 |
Diagnosis of argininosuccinic aciduria after valproic acid-induced hyperammonemia.
Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Ammonia; Arginine; Argininosuccinic Acid; F | 1987 |